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MCID: ALV002
MIFTS: 52

Alveolar Echinococcosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Alveolar Echinococcosis

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MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 77 54 60 45 15 74
Echinococcus Multilocularis Infection 12 60 74
Echinococcosis 54 74
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

60
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Endocrine diseases Gastrointestinal diseases Respiratory diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD9CM 36 122.7
MeSH 45 C536591
SNOMED-CT 69 21009004
ICD10 34 B67.6 B67.7
MESH via Orphanet 46 C536591
ICD10 via Orphanet 35 B67.5 B67.6 B67.7
UMLS via Orphanet 75 C0948954
Orphanet 60 ORPHA284
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Summaries for Alveolar Echinococcosis

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Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and cysticercosis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

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Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 32.0 CCL17 HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
2 cysticercosis 31.1 MT-CO1 TLR4
3 cystic echinococcosis 30.5 HLA-DRB1 MT-CO1 TLR4
4 cholangitis 30.2 HLA-B HLA-DRB1 TNF
5 sclerosing cholangitis 29.9 HLA-B HLA-DRB1 TNF
6 parasitic protozoa infectious disease 29.8 MT-CO1 TLR2 TNF
7 q fever 29.7 TLR2 TLR4 TNF
8 filariasis 29.7 TLR2 TLR4 TNF
9 pneumonia 29.6 TLR2 TLR4 TNF
10 human immunodeficiency virus type 1 29.6 HLA-A HLA-B LBR TNF
11 aspergillosis 29.4 CCL17 TLR2 TLR4 TNF
12 toxoplasmosis 29.4 HLA-DQB1 TLR2 TLR4 TNF
13 malaria 29.0 HLA-A HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
14 rheumatoid arthritis 28.8 HLA-B HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
15 polycystic echinococcosis 12.5
16 phenytoin or carbamazepine toxicity 10.4 HLA-A HLA-B
17 hemorrhagic fever 10.4 HLA-DRB1 TNF
18 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
19 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-A HLA-B
20 idiopathic inflammatory myopathy 10.4 HLA-B HLA-DRB1
21 budd-chiari syndrome 10.3
22 taeniasis 10.3
23 drug reaction with eosinophilia and systemic symptoms 10.3 HLA-B TNF
24 microscopic polyangiitis 10.3 HLA-DRB1 TNF
25 human herpesvirus 8 10.3 HLA-A HLA-B
26 paragonimiasis 10.3 CCL17 MT-CO1
27 postherpetic neuralgia 10.3 HLA-A HLA-B HLA-DRB1
28 pars planitis 10.3 HLA-A HLA-B HLA-DRB1
29 histoplasmosis 10.3 HLA-A HLA-B HLA-DRB1
30 actinic prurigo 10.3 HLA-DRB1 TNF
31 sympathetic ophthalmia 10.2 HLA-DRB1 TNF
32 prosthetic joint infection 10.2 TLR2 TLR4
33 central nervous system vasculitis 10.2 HLA-DRB1 TNF
34 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 CCL17 HLA-A HLA-B
35 colitis 10.2
36 anterior uveitis 10.2 HLA-A HLA-B TLR4
37 chronic pyelonephritis 10.2 HLA-A HLA-B TLR4
38 patulous eustachian tube 10.2
39 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
40 dengue shock syndrome 10.2 HLA-A HLA-DRB1 TNF
41 palindromic rheumatism 10.2 HLA-A HLA-DRB1 TNF
42 fungal keratitis 10.2 TLR2 TLR4
43 acute cervicitis 10.2 TLR2 TLR4
44 hemorrhagic fever with renal syndrome 10.2 HLA-B HLA-DRB1 TNF
45 hematopoietic stem cell transplantation 10.2 HLA-A HLA-B TNF
46 rheumatic heart disease 10.2 HLA-B HLA-DRB1 TNF
47 spondyloarthropathy 10.2 HLA-A HLA-B TNF
48 suppurative otitis media 10.2 TLR2 TLR4
49 severe cutaneous adverse reaction 10.2 HLA-A HLA-B TNF
50 haemophilus influenzae 10.2 TLR2 TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis
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Symptoms & Phenotypes for Alveolar Echinococcosis

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MGI Mouse Phenotypes related to Alveolar Echinococcosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCL17 HLA-DQB1 LBR TAP1 TAP2 TLR2
2 immune system MP:0005387 9.28 CCL17 HLA-DQB1 LBR MT-CO1 TAP1 TAP2
Sources

Drugs & Therapeutics for Alveolar Echinococcosis

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Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
4
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
5 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
6 Antiparasitic Agents ,Not Applicable
7 Liver Extracts Not Applicable
8 Anthelmintics ,Not Applicable
9 Anti-Infective Agents ,Not Applicable
10 cadexomer iodine
11 Antiprotozoal Agents Not Applicable
12 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Results of Comprehensive AE Management Completed NCT02509884
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
4 Periprosthetic Fracture Following Tibial Echinococcosis Completed NCT03622346 Not Applicable
5 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
6 Epi Cystic Hydatid Disease Peru Completed NCT00138346
7 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
8 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
9 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: alveolar echinococcosis

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Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

42
Liver, Lung, Brain, Testes, T Cells, Pancreas, Bone
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Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50) (show all 585)
# Title Authors Year
1
Vena cava inferior thrombosis in the course of advanced alveolar echinococcosis. ( 30608061 )
2019
2
Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study. ( 30615695 )
2019
3
The role of contrast-enhanced ultrasound in the diagnosis of hepatic alveolar echinococcosis. ( 30702614 )
2019
4
Is ex vivo liver resection and autotransplantation a valid alternative treatment for end-stage hepatic alveolar echinococcosis in Europe? ( 30718093 )
2019
5
Isolated Cerebral Alveolar Echinococcosis. ( 30740467 )
2019
6
Hunting Poses Only a Low Risk for Alveolar Echinococcosis. ( 30761283 )
2019
7
Outcomes of different surgical resection techniques for end-stage hepatic alveolar echinococcosis with inferior vena cava invasion. ( 30782476 )
2019
8
Doughnut sign of hepatic alveolar echinococcosis on FDG PET/CT: Clinical case report. ( 30813170 )
2019
9
FDG-PET/MRI Imaging for the Management of Alveolar Echinococcosis: Initial Clinical Experience at a Reference Centre in Austria. ( 30851233 )
2019
10
Echinococcus multilocularis Infection, Southern Ontario, Canada. ( 30666935 )
2019
11
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
12
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
13
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
14
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
15
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
16
Alveolar echinococcosis in a dog; analysis of clinical and histological findings and molecular identification of Echinococcus multilocularis. ( 29975636 )
2018
17
In vitro and in vivo efficacies of carbazole aminoalcohols in the treatment of alveolar echinococcosis. ( 29746870 )
2018
18
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
19
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2018
20
Transjugular intrahepatic portosystemic shunt for alveolar echinococcosis of the liver and Budd-Chiari syndrome. ( 29891417 )
2018
21
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
22
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
23
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
24
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
25
Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis. ( 29792228 )
2018
26
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
27
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis inA vitro and in a mouse model. ( 29625098 )
2018
28
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
29
Hepatic alveolar echinococcosis. ( 29653501 )
2018
30
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
31
Hepatobiliary and Pancreatic: Hepatic alveolar echinococcosis mimics cholangiocarcinoma: Role of EUS-FNA. ( 29896875 )
2018
32
Circulating cell-free DNA in patients with alveolar echinococcosis. ( 29679605 )
2018
33
Primary Alveolar Echinococcosis Presenting with Simultaneous Cerebral and Craniofacial Involvement. ( 29621086 )
2018
34
Alveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center. ( 29564733 )
2018
35
Intense Focus of Alveolar Echinococcosis, South Kyrgyzstan. ( 29774832 )
2018
36
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
37
Corrigendum to "Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years" [J Hepatol 49 (2008) 72-77]. ( 30206019 )
2018
38
Evaluation of the diagnostic value of the immunoblotting and ELISA tests using recombinant Em18 antigen in human alveolar echinococcosis from Xingjiang China. ( 30214538 )
2018
39
Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study. ( 30225656 )
2018
40
Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis. ( 30278480 )
2018
41
Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. ( 30315719 )
2018
42
Alveolar Echinococcosis Mimicking a Hepatic Neoplasm with Lymph Node Metastasis: A Case Report. ( 30386197 )
2018
43
Ex vivo liver resection and autotransplantation versus allotransplantation for end-stage hepatic alveolar echinococcosis. ( 30496849 )
2018
44
Vascular infiltration-based surgical planning in treating end-stage hepatic alveolar echinococcosis with ex vivo liver resection and autotransplantation. ( 30591376 )
2018
45
Molecular determination of suspected alveolar echinococcosis requiring surgical treatment in human cases from Poland ( 30726664 )
2018
46
Orbital alveolar echinococcosis: A case report. ( 29988895 )
2018
47
WITHDRAWN: Long-term outcomes of surgical intervention in patients with end-stage hepatic alveolar echinococcosis. ( 30025933 )
2018
48
Ex vivo liver resection and autotransplantation as alternative to allotransplantation for end-stage hepatic alveolar echinococcosis. ( 30031886 )
2018
49
Comparison of [18F]Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced Ultrasound for Evaluation of Hepatic Alveolar Echinococcosis Activity. ( 30077410 )
2018
50
Larval Echinococcus multilocularis infection reduces dextran sulphate sodium-induced colitis in mice by attenuating T helper type 1/type 17-mediated immune reactions. ( 29121394 )
2018
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Variations for Alveolar Echinococcosis

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Expression for Alveolar Echinococcosis

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Search GEO for disease gene expression data for Alveolar Echinococcosis.
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Pathways for Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.81 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1 TAP2
2
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 13.26 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1 TAP2
3
IL-2 Pathway 65
Show member pathways
 13.02 HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
4
PI3K-Akt signaling pathway 38
Show member pathways
 12.81 HLA-A HLA-B TLR2 TLR4 TNF
5
Human cytomegalovirus infection 38
Show member pathways
 12.77 HLA-A HLA-B TAP1 TAP2 TLR2 TLR4
6
Allograft rejection 1 38
Show member pathways
 12.65 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1 TAP2
7
Th17 cell differentiation 38
Show member pathways
 12.45 HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
8
NF-kappaB Signaling 4
12.42 TAP1 TAP2 TLR2 TNF
9
Interferon gamma signaling 67
Show member pathways
 12.38 HLA-A HLA-B HLA-DQB1 HLA-DRB1
10
Antigen processing-Cross presentation 67
Show member pathways
 12.25 HLA-A HLA-B TAP1 TAP2 TLR2 TLR4
11
Human T-cell leukemia virus 1 infection 38
12.23 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TNF
12
Proteoglycans in cancer 38
12.13 TLR2 TLR4 TNF
13
Toxoplasmosis 38
Show member pathways
 12.13 HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
14
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.1 TLR2 TLR4 TNF
15
Influenza A 38
Show member pathways
 12.09 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1 TAP2
16
Tuberculosis 38
12.05 HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
17
Bacterial infections in CF airways 23
Show member pathways
 12.02 TLR2 TLR4 TNF
18
Colorectal Cancer Metastasis 65
12.02 TLR2 TLR4 TNF
19
Cell adhesion molecules (CAMs) 38
11.98 HLA-A HLA-B HLA-DQB1 HLA-DRB1
20
Th1 Differentiation Pathway 66
Show member pathways
 11.91 TLR2 TLR4 TNF
21
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.89 TLR2 TLR4 TNF
22
Hematopoietic cell lineage 38
11.76 HLA-DQB1 HLA-DRB1 TNF
23
Amoebiasis 38
11.75 TLR2 TLR4 TNF
24
Rheumatoid arthritis 38
11.51 HLA-DQB1 HLA-DRB1 TLR2 TLR4 TNF
25
Legionellosis 38
11.47 TLR2 TLR4 TNF
26
Malaria 38
11.41 TLR2 TLR4 TNF
27
Phagosome 38
11.41 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1 TAP2
28
MSP-RON Signaling 65
11.39 TLR2 TLR4 TNF
29
Cytokines and Inflammatory Response 1
11.1 HLA-DRB1 TNF
30
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 67
10.96 HLA-A HLA-B TAP1 TAP2
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GO Terms for Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 HLA-A HLA-B HLA-DRB1 TLR2 TLR4 TNF
2 MHC class II protein complex GO:0042613 9.48 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-A HLA-B HLA-DQB1 HLA-DRB1
4 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B
5 MHC class I peptide loading complex GO:0042824 9.4 TAP1 TAP2
6 TAP complex GO:0042825 9.37 TAP1 TAP2
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-DQB1 HLA-DRB1
8 phagocytic vesicle membrane GO:0030670 9.02 HLA-A HLA-B TAP1 TAP2 TLR2
9 membrane GO:0016020 10.2 HLA-A HLA-B HLA-DQB1 HLA-DRB1 LBR MT-CO1
10 integral component of membrane GO:0016021 10.06 HLA-A HLA-B HLA-DQB1 HLA-DRB1 LBR MT-CO1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.96 HLA-B HLA-DRB1 TAP1 TAP2
2 inflammatory response GO:0006954 9.95 CCL17 TLR2 TLR4 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 TLR2 TLR4 TNF
4 cellular response to interferon-gamma GO:0071346 9.8 CCL17 TLR2 TLR4
5 immune system process GO:0002376 9.8 HLA-A HLA-B HLA-DRB1 TAP1 TAP2 TLR2
6 positive regulation of inflammatory response GO:0050729 9.77 TLR2 TLR4 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.73 TLR2 TLR4 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 TLR2 TLR4 TNF
9 negative regulation of interferon-gamma production GO:0032689 9.68 HLA-DRB1 TLR4
10 negative regulation of interleukin-6 production GO:0032715 9.68 TLR4 TNF
11 positive regulation of interferon-beta production GO:0032728 9.68 TLR2 TLR4
12 negative regulation of myoblast differentiation GO:0045662 9.68 CCL17 TNF
13 positive regulation of interleukin-12 production GO:0032735 9.67 TLR2 TLR4
14 positive regulation of interleukin-10 production GO:0032733 9.67 TLR2 TLR4
15 positive regulation of T cell mediated cytotoxicity GO:0001916 9.67 HLA-A HLA-B
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TLR2 TLR4 TNF
17 interferon-gamma-mediated signaling pathway GO:0060333 9.67 HLA-A HLA-B HLA-DQB1 HLA-DRB1
18 microglial cell activation GO:0001774 9.65 TLR2 TNF
19 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.65 HLA-DQB1 HLA-DRB1
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.64 TLR2 TLR4
21 regulation of cytokine secretion GO:0050707 9.64 TLR2 TLR4
22 I-kappaB phosphorylation GO:0007252 9.63 TLR2 TLR4
23 cellular response to lipoteichoic acid GO:0071223 9.62 TLR2 TLR4
24 peptide transport GO:0015833 9.62 TAP1 TAP2
25 antigen processing and presentation GO:0019882 9.62 HLA-A HLA-B HLA-DQB1 HLA-DRB1
26 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 TLR4 TNF
27 T-helper 1 type immune response GO:0042088 9.61 HLA-DRB1 TLR4
28 positive regulation of interleukin-8 production GO:0032757 9.61 TLR2 TLR4 TNF
29 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.6 HLA-A HLA-B
30 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.58 TAP1 TAP2
31 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.58 HLA-A HLA-B
32 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR4 TNF
33 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.57 TAP1 TAP2
34 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.55 HLA-DQB1 HLA-DRB1
35 protection from natural killer cell mediated cytotoxicity GO:0042270 9.54 HLA-A HLA-B
36 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.51 HLA-DQB1 HLA-DRB1
37 cytosol to ER transport GO:0046967 9.48 TAP1 TAP2
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.46 TLR2 TLR4
39 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.46 HLA-A HLA-B TAP1 TAP2
40 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.26 HLA-A HLA-B TAP1 TAP2
41 immune response GO:0006955 9.23 CCL17 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TLR2

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.76 CCL17 HLA-A HLA-B TLR4
2 MHC protein binding GO:0042287 9.43 TAP1 TAP2
3 MHC class II receptor activity GO:0032395 9.4 HLA-DQB1 HLA-DRB1
4 peptide transmembrane transporter activity GO:1904680 9.37 TAP1 TAP2
5 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
6 TAP1 binding GO:0046978 9.26 TAP1 TAP2
7 MHC class Ib protein binding GO:0023029 9.16 TAP1 TAP2
8 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TAP1
9 peptide antigen-transporting ATPase activity GO:0015433 8.96 TAP1 TAP2
Sources

Sources for Alveolar Echinococcosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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