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MCID: ALV002
MIFTS: 51

Alveolar Echinococcosis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Alveolar Echinococcosis

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MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 76 53 59 15 73
Echinococcus Multilocularis Infection 12 59 73
Echinococcosis 53 73
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

59
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD10 33 B67.6 B67.7
ICD9CM 35 122.7
SNOMED-CT 68 21009004 240816000
Orphanet 59 ORPHA284
MESH via Orphanet 45 C536591
UMLS via Orphanet 74 C0948954
ICD10 via Orphanet 34 B67.6 B67.7 B67.5
Sources

Summaries for Alveolar Echinococcosis

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Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and cholangitis. An important gene associated with Alveolar Echinococcosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Metronidazole and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

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Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 32.2 CCL17 HLA-B HLA-DRB1 MT-CO1 TNF
2 cholangitis 30.3 HLA-B HLA-DRB1 TNF
3 cystic echinococcosis 30.1 HLA-DRB1 MT-CO1 TLR4
4 rheumatoid arthritis 28.4 HLA-B HLA-DRB1 TLR2 TLR4 TNF
5 malaria 27.4 HLA-A HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
6 phenytoin or carbamazepine toxicity 10.8 HLA-A HLA-B
7 hepatitis 10.8
8 atrial tachyarrhythmia with short pr interval 10.8 HLA-A HLA-B
9 idiopathic inflammatory myopathy 10.8 HLA-B HLA-DRB1
10 acute disseminated encephalomyelitis 10.7 HLA-B HLA-DRB1
11 beryllium disease 10.7 HLA-DRB1 TNF
12 chronic pyelonephritis 10.7 HLA-A HLA-B
13 autoimmune pancreatitis 10.7 HLA-DRB1 TNF
14 chronic beryllium disease 10.7 HLA-DRB1 TNF
15 anca-associated vasculitis 10.6 HLA-DRB1 TNF
16 lichen sclerosus 10.6 HLA-DRB1 TNF
17 paragonimiasis 10.6 CCL17 MT-CO1
18 actinic prurigo 10.6 HLA-DRB1 TNF
19 microscopic colitis 10.6 HLA-DRB1 TNF
20 central nervous system vasculitis 10.6 HLA-DRB1 TNF
21 postherpetic neuralgia 10.5 HLA-A HLA-B HLA-DRB1
22 rheumatoid vasculitis 10.5 HLA-DRB1 TNF
23 pars planitis 10.5 HLA-A HLA-B HLA-DRB1
24 histoplasmosis 10.5 HLA-A HLA-B HLA-DRB1
25 pure red-cell aplasia 10.5 HLA-A HLA-B HLA-DRB1
26 vogt-koyanagi-harada disease 10.5 HLA-A HLA-B HLA-DRB1
27 cytomegalovirus retinitis 10.5 HLA-B TNF
28 microscopic polyangiitis 10.4 HLA-B HLA-DRB1 TNF
29 cerebritis 10.4
30 palindromic rheumatism 10.4 HLA-A HLA-DRB1 TNF
31 rheumatic heart disease 10.4 HLA-A HLA-DRB1 TNF
32 panuveitis 10.4 HLA-B HLA-DRB1 TNF
33 dengue hemorrhagic fever 10.4 HLA-A HLA-DRB1 TNF
34 haemophilus influenzae 10.4 TLR2 TNF
35 intermediate uveitis 10.4 HLA-B TNF
36 birdshot chorioretinopathy 10.4 HLA-A HLA-C
37 aphthous stomatitis 10.4 HLA-A HLA-B TNF
38 glaucomatocyclitic crisis 10.4 HLA-A HLA-B HLA-C
39 trachoma 10.4 HLA-C TNF
40 human herpesvirus 8 10.4 HLA-A HLA-B HLA-C
41 hemorrhagic fever 10.4 HLA-DRB1 TNF
42 rheumatic disease 10.4 HLA-B HLA-DRB1 TNF
43 mycobacterium abscessus 10.3 TLR2 TNF
44 severe cutaneous adverse reaction 10.3 HLA-A HLA-B HLA-C
45 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DRB1 TNF
46 anterior uveitis 10.3 HLA-A HLA-B TLR2
47 sympathetic ophthalmia 10.3 HLA-C HLA-DRB1 TNF
48 primary systemic mycosis 10.3 TLR2 TNF
49 spondylarthropathy 10.2 TLR4 TNF
50 rheumatic fever 10.2 HLA-DRB1 TLR2 TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis
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Symptoms & Phenotypes for Alveolar Echinococcosis

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GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.69 HLA-B HLA-A HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.69 HLA-B HLA-A HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.69 HLA-B HLA-A HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.69 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.69 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.69 HLA-B HLA-A HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.69 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.69 HLA-A HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.69 HLA-A HLA-B HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.69 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.69 HLA-B HLA-A HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.69 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.69 HLA-B HLA-A HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.69 HLA-B HLA-A HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.69 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL17 LBR MT-CO1 TAP1 TAP2 TLR2
Sources

Drugs & Therapeutics for Alveolar Echinococcosis

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Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
3
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
4 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
5 Antiparasitic Agents ,Not Applicable
6 Liver Extracts Not Applicable
7 Anthelmintics ,Not Applicable
8 Anti-Infective Agents ,Not Applicable
9 Antimitotic Agents Not Applicable
10 Antiprotozoal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Results of Comprehensive AE Management Completed NCT02509884
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
4 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
5 Epi Cystic Hydatid Disease Peru Completed NCT00138346
6 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
7 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
8 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

41
Liver, Lung, Brain, Testes, Pancreas, Skin, Adrenal Gland
Sources

Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50) (show all 482)
# Title Authors Year
1
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
2
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
3
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
4
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
5
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
6
Alveolar echinococcosis in a dog; analysis of clinical and histological findings and molecular identification of Echinococcus multilocularis. ( 29975636 )
2018
7
In vitro and in vivo efficacies of carbazole aminoalcohols in the treatment of alveolar echinococcosis. ( 29746870 )
2018
8
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
9
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2018
10
Transjugular intrahepatic portosystemic shunt for alveolar echinococcosis of the liver and Budd-Chiari syndrome. ( 29891417 )
2018
11
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
12
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
13
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
14
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
15
Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis. ( 29792228 )
2018
16
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
17
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis inA vitro and in a mouse model. ( 29625098 )
2018
18
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
19
Hepatic alveolar echinococcosis. ( 29653501 )
2018
20
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
21
Hepatobiliary and Pancreatic: Hepatic alveolar echinococcosis mimics cholangiocarcinoma: Role of EUS-FNA. ( 29896875 )
2018
22
Circulating cell-free DNA in patients with alveolar echinococcosis. ( 29679605 )
2018
23
Primary Alveolar Echinococcosis Presenting with Simultaneous Cerebral and Craniofacial Involvement. ( 29621086 )
2018
24
Alveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center. ( 29564733 )
2018
25
Intense Focus of Alveolar Echinococcosis, South Kyrgyzstan. ( 29774832 )
2018
26
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
27
Two-stage hepatectomy for multiple giant alveolar echinococcosis. ( 28816980 )
2017
28
Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients: Case report. ( 29049181 )
2017
29
Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases. ( 28070011 )
2017
30
Alveolar echinococcosis presenting with simultaneous cerebral and spinal involvement. ( 28554898 )
2017
31
Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis. ( 28715408 )
2017
32
Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions. ( 28542546 )
2017
33
Detection of Echinococcus multilocularis and other foodborne parasites in fox, cat and dog faeces collected in kitchen gardens in a highly endemic area for alveolar echinococcosis. ( 28748783 )
2017
34
Obstructive Hydrocephalus due to Intracerebral Alveolar Echinococcosis. ( 29228350 )
2017
35
Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis. ( 28457324 )
2017
36
Comparison of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance (MR) Imaging to T1 Mapping in Characterization of Hepatic Alveolar Echinococcosis. ( 29259149 )
2017
37
Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases. ( 29232038 )
2017
38
Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging. ( 29110943 )
2017
39
FDG-PET/MR Imaging in Alveolar Echinococcosis. ( 28935243 )
2017
40
Enhanced recovery after surgery program in patients from Tibet Plateau undergoing surgeries for hepatic alveolar echinococcosis. ( 29078881 )
2017
41
A European survey of perendoscopic treatment of biliary complications in patients with alveolar echinococcosis. ( 27788612 )
2017
42
Screening of antigenic vesicular fluid proteins of Echinococcus multilocularis as potential viability biomarkers to monitor drug response in alveolar echinococcosis patients. ( 28697272 )
2017
43
Disseminated alveolar echinococcosis resembling metastatic malignancy: a case report. ( 28416007 )
2017
44
Fatal Liver and Lung Alveolar Echinococcosis with Newly Developed Neurologic Symptoms due to the Brain Involvement. ( 28825028 )
2017
45
Vertebral alveolar echinococcosis-a case report, systematic analysis, and review of the literature. ( 28807628 )
2017
46
Pulmonary involvement in alveolar echinococcosis. ( 28416238 )
2017
47
Cystic and alveolar echinococcosis: Successes and continuing challenges. ( 28426657 )
2017
48
Alveolar echinococcosis in Germany, 1992-2016. An update based on the newly established national AE database. ( 29090421 )
2017
49
To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis. ( 28270242 )
2017
50
Combined resection of the right liver lobe and retrohepatic inferior vena cava to treat hepatic alveolar echinococcosis: A case report. ( 28930853 )
2017
Sources

Variations for Alveolar Echinococcosis

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Expression for Alveolar Echinococcosis

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Search GEO for disease gene expression data for Alveolar Echinococcosis.
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Pathways for Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.83 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
2
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.18 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
3
Actin Nucleation by ARP-WASP Complex 64
Show member pathways
 12.78 HLA-A HLA-B HLA-C HLA-DRB1
4
PI3K-Akt signaling pathway 37
Show member pathways
 12.78 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
5
Allograft rejection 1 37
Show member pathways
 12.65 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
6
Regulation of IFNA signaling 66
Show member pathways
 12.49 HLA-A HLA-B HLA-C TNF
7
NF-kappaB Signaling 4
12.43 TAP1 TAP2 TLR2 TNF
8
Interferon gamma signaling 66
Show member pathways
 12.4 HLA-A HLA-B HLA-C HLA-DRB1
9
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.37 HLA-A HLA-B HLA-C TNF
10
TRAF Pathway 64
Show member pathways
 12.35 TLR2 TLR4 TNF
11
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.32 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
12
Th17 cell differentiation 37
Show member pathways
 12.3 HLA-DRB1 TLR2 TLR4 TNF
13
Influenza A 37
Show member pathways
 12.3 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
14
HTLV-I infection 37
12.26 HLA-A HLA-B HLA-C HLA-DRB1 TNF
15
Antigen processing-Cross presentation 66
Show member pathways
 12.25 HLA-A HLA-B HLA-C TAP1 TAP2 TLR2
16
Epstein-Barr virus infection 37
12.16 HLA-A HLA-B HLA-C HLA-DRB1
17
Proteoglycans in cancer 37
12.15 TLR2 TLR4 TNF
18
Viral carcinogenesis 37
12.14 HLA-A HLA-B HLA-C
19
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.11 TLR2 TLR4 TNF
20
Th1 Differentiation Pathway 65
Show member pathways
 12.1 TLR2 TLR4 TNF
21
Toxoplasmosis 37
Show member pathways
 12.1 HLA-DRB1 TLR2 TLR4 TNF
22
Tuberculosis 37
12.06 HLA-DRB1 TLR2 TLR4 TNF
23
Bacterial infections in CF airways 22
Show member pathways
 12.03 TLR2 TLR4 TNF
24
Colorectal Cancer Metastasis 64
12.03 TLR2 TLR4 TNF
25
Cellular senescence (KEGG) 37
12.01 HLA-A HLA-B HLA-C
26
Cell adhesion molecules (CAMs) 37
11.95 HLA-A HLA-B HLA-C HLA-DRB1
27
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.93 HLA-A HLA-B HLA-C
28
Amoebiasis 37
11.77 TLR2 TLR4 TNF
29
Rheumatoid arthritis 37
11.69 HLA-DRB1 TLR2 TLR4 TNF
30
Legionellosis 37
11.48 TLR2 TLR4 TNF
31
Malaria 37
11.41 TLR2 TLR4 TNF
32
Phagosome 37
11.41 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
33
MSP-RON Signaling 64
11.39 TLR2 TLR4 TNF
34
Cytokines and Inflammatory Response 1
11.14 HLA-DRB1 TNF
35
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 66
10.95 HLA-A HLA-B HLA-C TAP1 TAP2
Sources

GO Terms for Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
2 early endosome membrane GO:0031901 9.7 HLA-A HLA-B HLA-C
3 cell surface GO:0009986 9.7 HLA-A HLA-B HLA-C HLA-DRB1 TLR2 TLR4
4 secretory granule membrane GO:0030667 9.65 HLA-B HLA-C TLR2
5 integral component of endoplasmic reticulum membrane GO:0030176 9.63 LBR TAP1 TAP2
6 ER to Golgi transport vesicle membrane GO:0012507 9.62 HLA-A HLA-B HLA-C HLA-DRB1
7 recycling endosome membrane GO:0055038 9.61 HLA-A HLA-B HLA-C
8 intrinsic component of plasma membrane GO:0031226 9.54 TLR2 TLR4
9 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B HLA-C
10 TAP complex GO:0042825 9.4 TAP1 TAP2
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-C HLA-DRB1
12 phagocytic vesicle membrane GO:0030670 9.1 HLA-A HLA-B HLA-C TAP1 TAP2 TLR2
13 membrane GO:0016020 10.25 HLA-A HLA-B HLA-C HLA-DRB1 LBR MT-CO1
14 integral component of membrane GO:0016021 10.11 HLA-A HLA-B HLA-C HLA-DRB1 LBR MT-CO1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL17 TLR2 TLR4 TNF
2 viral process GO:0016032 9.88 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 TLR2 TLR4 TNF
4 immune system process GO:0002376 9.76 HLA-A HLA-B HLA-C HLA-DRB1 TAP1 TAP2
5 type I interferon signaling pathway GO:0060337 9.74 HLA-A HLA-B HLA-C
6 interferon-gamma-mediated signaling pathway GO:0060333 9.73 HLA-A HLA-B HLA-C HLA-DRB1
7 positive regulation of interleukin-6 production GO:0032755 9.71 TLR2 TLR4 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 TLR2 TLR4 TNF
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TLR2 TLR4 TNF
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.66 TLR2 TLR4
11 negative regulation of interleukin-6 production GO:0032715 9.66 TLR4 TNF
12 negative regulation of interferon-gamma production GO:0032689 9.65 HLA-DRB1 TLR4
13 positive regulation of interferon-beta production GO:0032728 9.65 TLR2 TLR4
14 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 TLR4
15 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR4 TNF
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.65 HLA-A HLA-B HLA-C TAP1 TAP2
17 positive regulation of interleukin-10 production GO:0032733 9.64 TLR2 TLR4
18 negative regulation of myoblast differentiation GO:0045662 9.64 CCL17 TNF
19 positive regulation of chemokine production GO:0032722 9.63 TLR2 TLR4 TNF
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 TLR2 TLR4
21 I-kappaB phosphorylation GO:0007252 9.62 TLR2 TLR4
22 antigen processing and presentation GO:0019882 9.62 HLA-A HLA-B HLA-C HLA-DRB1
23 regulation of cytokine secretion GO:0050707 9.61 TLR2 TLR4
24 peptide transport GO:0015833 9.61 TAP1 TAP2
25 cellular response to lipoteichoic acid GO:0071223 9.6 TLR2 TLR4
26 T-helper 1 type immune response GO:0042088 9.59 HLA-DRB1 TLR4
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TLR4 TNF
28 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.58 TAP1 TAP2
29 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.56 TAP1 TAP2
30 immune response GO:0006955 9.56 CCL17 HLA-A HLA-B HLA-C HLA-DRB1 TLR2
31 protection from natural killer cell mediated cytotoxicity GO:0042270 9.55 HLA-A HLA-B
32 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B HLA-C
33 cytosol to ER transport GO:0046967 9.49 TAP1 TAP2
34 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.02 HLA-A HLA-B HLA-C TAP1 TAP2

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 CCL17 HLA-A HLA-B HLA-C TLR4
2 lipopolysaccharide binding GO:0001530 9.48 TLR2 TLR4
3 MHC protein binding GO:0042287 9.46 TAP1 TAP2
4 lipopolysaccharide receptor activity GO:0001875 9.43 TLR2 TLR4
5 peptide-transporting ATPase activity GO:0015440 9.4 TAP1 TAP2
6 TAP1 binding GO:0046978 9.37 TAP1 TAP2
7 peptide antigen-transporting ATPase activity GO:0015433 9.26 TAP1 TAP2
8 peptide transmembrane transporter activity GO:1904680 9.16 TAP1 TAP2
9 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DRB1 TAP1
10 MHC class Ib protein binding GO:0023029 8.96 TAP1 TAP2
Sources

Sources for Alveolar Echinococcosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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