MCID: ALV002
MIFTS: 54

Alveolar Echinococcosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 76 53 59 44 15 73
Echinococcus Multilocularis Infection 12 59 73
Echinococcosis 53 73
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

59
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD10 33 B67.6 B67.7
ICD9CM 35 122.7
MeSH 44 C536591
SNOMED-CT 68 21009004
Orphanet 59 ORPHA284
MESH via Orphanet 45 C536591
UMLS via Orphanet 74 C0948954
ICD10 via Orphanet 34 B67.6 B67.7 B67.5

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and cysticercosis. An important gene associated with Alveolar Echinococcosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 32.3 CCL17 HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
2 cysticercosis 31.0 MT-CO1 TLR4
3 cystic echinococcosis 30.4 HLA-DRB1 MT-CO1 TLR4
4 cholangitis 30.1 HLA-B HLA-DRB1 TNF
5 toxoplasmosis 30.1 TLR2 TLR4 TNF
6 parasitic protozoa infectious disease 29.7 MT-CO1 TLR2 TNF
7 q fever 29.7 TLR2 TLR4 TNF
8 pneumonia 29.7 TLR2 TLR4 TNF
9 rheumatoid arthritis 29.6 HLA-B HLA-DRB1 TLR2 TLR4 TNF
10 human immunodeficiency virus type 1 29.5 HLA-A HLA-B HLA-C LBR TNF
11 malaria 29.0 CD36 HLA-A HLA-B HLA-DRB1 MT-CO1 TLR2
12 polycystic echinococcosis 12.5
13 taeniasis 10.4
14 budd-chiari syndrome 10.4
15 phenytoin or carbamazepine toxicity 10.3 HLA-A HLA-B
16 atrial tachyarrhythmia with short pr interval 10.2 HLA-A HLA-B
17 idiopathic inflammatory myopathy 10.2 HLA-B HLA-DRB1
18 hemorrhagic fever 10.2 HLA-DRB1 TNF
19 colitis 10.2
20 paragonimiasis 10.2 CCL17 MT-CO1
21 beryllium disease 10.2 HLA-DRB1 TNF
22 drug reaction with eosinophilia and systemic symptoms 10.2 HLA-B TNF
23 postherpetic neuralgia 10.2 HLA-A HLA-B HLA-DRB1
24 chronic beryllium disease 10.2 HLA-DRB1 TNF
25 pars planitis 10.2 HLA-A HLA-B HLA-DRB1
26 anca-associated vasculitis 10.2 HLA-DRB1 TNF
27 histoplasmosis 10.2 HLA-A HLA-B HLA-DRB1
28 pure red-cell aplasia 10.2 HLA-A HLA-B HLA-DRB1
29 prosthetic joint infection 10.2 TLR2 TLR4
30 actinic prurigo 10.2 HLA-DRB1 TNF
31 vogt-koyanagi-harada disease 10.2 HLA-A HLA-B HLA-DRB1
32 microscopic colitis 10.1 HLA-DRB1 TNF
33 fungal keratitis 10.1 TLR2 TLR4
34 acute cervicitis 10.1 TLR2 TLR4
35 central nervous system vasculitis 10.1 HLA-DRB1 TNF
36 acute disseminated encephalomyelitis 10.1 HLA-B HLA-DRB1
37 rheumatoid vasculitis 10.1 HLA-DRB1 TNF
38 suppurative otitis media 10.1 TLR2 TLR4
39 autoimmune gastritis 10.1 HLA-B TNF
40 chronic pyelonephritis 10.1 HLA-A HLA-B TLR4
41 myositis fibrosa 10.1 TLR2 TLR4
42 haemophilus influenzae 10.1 TLR2 TNF
43 qualitative platelet defect 10.1 CD36 HLA-A
44 congenital cytomegalovirus 10.1 TLR2 TNF
45 microscopic polyangiitis 10.1 HLA-B HLA-DRB1 TNF
46 dengue shock syndrome 10.1 HLA-A HLA-DRB1 TNF
47 palindromic rheumatism 10.1 HLA-A HLA-DRB1 TNF
48 intermediate uveitis 10.1 HLA-B TNF
49 periapical periodontitis 10.1 TLR2 TNF
50 hemorrhagic fever with renal syndrome 10.1 HLA-B HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.69 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.69 HLA-A HLA-B HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.69 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.69 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.69 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.69 HLA-A HLA-B HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.69 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.69 HLA-A HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.69 HLA-A HLA-B HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.69 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.69 HLA-A HLA-B HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.69 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.69 HLA-A HLA-B HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.69 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.69 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 CCL17 CD36 CD8A LBR MT-CO1 TLR2
2 adipose tissue MP:0005375 9.55 CD36 LBR TLR2 TLR4 TNF
3 immune system MP:0005387 9.23 CCL17 CD36 CD8A LBR MT-CO1 TLR2

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
4
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
5 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
6 Antiparasitic Agents ,Not Applicable
7 Liver Extracts Not Applicable
8 Anti-Infective Agents ,Not Applicable
9 Anthelmintics ,Not Applicable
10 cadexomer iodine
11 Antiprotozoal Agents Not Applicable
12 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Results of Comprehensive AE Management Completed NCT02509884
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
4 Periprosthetic Fracture Following Tibial Echinococcosis Completed NCT03622346 Not Applicable
5 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
6 Epi Cystic Hydatid Disease Peru Completed NCT00138346
7 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
8 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
9 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: alveolar echinococcosis

Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

41
Liver, Lung, Brain, Testes, T Cells, Skin, Bone

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 572)
# Title Authors Year
1
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
2
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
3
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
4
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
5
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
6
Alveolar echinococcosis in a dog; analysis of clinical and histological findings and molecular identification of Echinococcus multilocularis. ( 29975636 )
2018
7
In vitro and in vivo efficacies of carbazole aminoalcohols in the treatment of alveolar echinococcosis. ( 29746870 )
2018
8
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
9
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2018
10
Transjugular intrahepatic portosystemic shunt for alveolar echinococcosis of the liver and Budd-Chiari syndrome. ( 29891417 )
2018
11
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
12
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
13
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
14
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
15
Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis. ( 29792228 )
2018
16
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
17
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis inA vitro and in a mouse model. ( 29625098 )
2018
18
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
19
Hepatic alveolar echinococcosis. ( 29653501 )
2018
20
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
21
Hepatobiliary and Pancreatic: Hepatic alveolar echinococcosis mimics cholangiocarcinoma: Role of EUS-FNA. ( 29896875 )
2018
22
Circulating cell-free DNA in patients with alveolar echinococcosis. ( 29679605 )
2018
23
Primary Alveolar Echinococcosis Presenting with Simultaneous Cerebral and Craniofacial Involvement. ( 29621086 )
2018
24
Alveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center. ( 29564733 )
2018
25
Intense Focus of Alveolar Echinococcosis, South Kyrgyzstan. ( 29774832 )
2018
26
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
27
Orbital alveolar echinococcosis: A case report. ( 29988895 )
2018
28
WITHDRAWN: Long-term outcomes of surgical intervention in patients with end-stage hepatic alveolar echinococcosis. ( 30025933 )
2018
29
Ex vivo liver resection and autotransplantation as alternative to allotransplantation for end-stage hepatic alveolar echinococcosis. ( 30031886 )
2018
30
Comparison of [18F]Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced Ultrasound for Evaluation of Hepatic Alveolar Echinococcosis Activity. ( 30077410 )
2018
31
Corrigendum to "Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years" [J Hepatol 49 (2008) 72-77]. ( 30206019 )
2018
32
Evaluation of the diagnostic value of the immunoblotting and ELISA tests using recombinant Em18 antigen in human alveolar echinococcosis from Xingjiang China. ( 30214538 )
2018
33
Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study. ( 30225656 )
2018
34
Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis. ( 30278480 )
2018
35
Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. ( 30315719 )
2018
36
Alveolar Echinococcosis Mimicking a Hepatic Neoplasm with Lymph Node Metastasis: A Case Report. ( 30386197 )
2018
37
Ex Vivo Liver Resection and Autotransplantation versus Allotransplantation for End-stage Hepatic Alveolar Echinococcosis. ( 30496849 )
2018
38
Larval Echinococcus multilocularis infection reduces dextran sulphate sodium-induced colitis in mice by attenuating T helper type 1/type 17-mediated immune reactions. ( 29121394 )
2018
39
Analysis for genetic loci controlling protoscolex development in the Echinococcus multilocularis infection using congenic mice. ( 30030204 )
2018
40
Suppression of mouse miRNA-222-3p in response to Echinococcus multilocularis infection. ( 30212751 )
2018
41
Two-stage hepatectomy for multiple giant alveolar echinococcosis. ( 28816980 )
2017
42
Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients: Case report. ( 29049181 )
2017
43
Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases. ( 28070011 )
2017
44
Alveolar echinococcosis presenting with simultaneous cerebral and spinal involvement. ( 28554898 )
2017
45
Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis. ( 28715408 )
2017
46
Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions. ( 28542546 )
2017
47
Detection of Echinococcus multilocularis and other foodborne parasites in fox, cat and dog faeces collected in kitchen gardens in a highly endemic area for alveolar echinococcosis. ( 28748783 )
2017
48
Obstructive Hydrocephalus due to Intracerebral Alveolar Echinococcosis. ( 29228350 )
2017
49
Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis. ( 28457324 )
2017
50
Comparison of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance (MR) Imaging to T1 Mapping in Characterization of Hepatic Alveolar Echinococcosis. ( 29259149 )
2017

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 CD36 CD8A HLA-A HLA-B HLA-C HLA-DRB1
2
Show member pathways
13.22 CD36 HLA-A HLA-B HLA-C HLA-DRB1 TNF
3
Show member pathways
13.18 CD36 CD8A HLA-A HLA-B HLA-C HLA-DRB1
4
Show member pathways
12.92 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
5
Show member pathways
12.85 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
6
Show member pathways
12.71 CD8A HLA-A HLA-B HLA-C HLA-DRB1 TNF
7
Show member pathways
12.49 HLA-DRB1 TLR2 TLR4 TNF
8
Show member pathways
12.49 HLA-A HLA-B HLA-C HLA-DRB1 TLR2 TLR4
9
Show member pathways
12.42 HLA-A HLA-B HLA-C HLA-DRB1
10
Show member pathways
12.4 HLA-A HLA-B HLA-C TNF
11 12.24 HLA-A HLA-B HLA-C HLA-DRB1 TNF
12 12.16 TLR2 TLR4 TNF
13 12.16 HLA-A HLA-B HLA-C
14
Show member pathways
12.16 CD36 TLR2 TLR4 TNF
15
Show member pathways
12.15 HLA-A HLA-B HLA-C TNF
16
Show member pathways
12.15 HLA-DRB1 TLR2 TLR4 TNF
17 12.12 HLA-DRB1 TLR2 TLR4 TNF
18
Show member pathways
12.07 TLR2 TLR4 TNF
19 12.07 TLR2 TLR4 TNF
20 12.05 HLA-A HLA-B HLA-C
21 11.98 CD8A HLA-A HLA-B HLA-C
22
Show member pathways
11.96 TLR2 TLR4 TNF
23
Show member pathways
11.95 CD36 CD8A HLA-A HLA-B HLA-C TLR2
24 11.94 HLA-A HLA-B HLA-C HLA-DRB1 TLR2 TNF
25
Show member pathways
11.93 CD36 TLR2 TLR4 TNF
26 11.9 CD36 CD8A TNF
27
Show member pathways
11.88 CD8A HLA-A HLA-DRB1
28 11.88 CD8A HLA-A HLA-B HLA-C HLA-DRB1
29
Show member pathways
11.86 CD8A HLA-A HLA-DRB1
30 11.8 TLR2 TLR4 TNF
31 11.76 CD36 CD8A HLA-DRB1 TNF
32 11.71 HLA-DRB1 TLR2 TLR4 TNF
33 11.64 CCL17 CD36 TNF
34
Show member pathways
11.57 CD8A HLA-A TNF
35 11.51 TLR2 TLR4 TNF
36 11.45 TLR2 TLR4 TNF
37 11.36 CD36 TLR2 TLR4 TNF
38 11.35 CD36 HLA-A HLA-B HLA-C HLA-DRB1 TLR2
39 11.19 CD36 TLR4
40 11.14 HLA-DRB1 TNF
41 11.08 HLA-A HLA-B HLA-C
42 10.87 CD36 TNF

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.98 CD36 CD8A HLA-A HLA-B TLR2 TLR4
2 Golgi apparatus GO:0005794 9.95 CD36 HLA-A HLA-B HLA-C HLA-DRB1 TLR2
3 external side of plasma membrane GO:0009897 9.77 CD36 CD8A HLA-DRB1 TLR4 TNF
4 early endosome membrane GO:0031901 9.7 HLA-A HLA-B HLA-C
5 secretory granule membrane GO:0030667 9.67 HLA-B HLA-C TLR2
6 recycling endosome membrane GO:0055038 9.63 HLA-A HLA-B HLA-C
7 phagocytic vesicle membrane GO:0030670 9.62 HLA-A HLA-B HLA-C TLR2
8 ER to Golgi transport vesicle membrane GO:0012507 9.56 HLA-A HLA-B HLA-C HLA-DRB1
9 MHC class I protein complex GO:0042612 9.33 HLA-A HLA-B HLA-C
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-C HLA-DRB1
11 cell surface GO:0009986 9.23 CD36 HLA-A HLA-B HLA-C HLA-DRB1 TLR2
12 membrane GO:0016020 10.25 CD36 CD8A HLA-A HLA-B HLA-C HLA-DRB1
13 plasma membrane GO:0005886 10.19 CD36 CD8A HLA-A HLA-B HLA-C HLA-DRB1
14 integral component of membrane GO:0016021 10.14 CD36 CD8A HLA-A HLA-B HLA-C HLA-DRB1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CCL17 TLR2 TLR4 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 CCL17 CD36 TLR4 TNF
3 regulation of immune response GO:0050776 9.93 CD8A HLA-A HLA-B HLA-C
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 CD36 TLR4 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.89 CD36 TLR4 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD36 TLR2 TLR4 TNF
7 cellular response to interferon-gamma GO:0071346 9.85 CCL17 TLR2 TLR4
8 defense response to Gram-positive bacterium GO:0050830 9.85 CD36 TLR2 TNF
9 positive regulation of inflammatory response GO:0050729 9.84 TLR2 TLR4 TNF
10 type I interferon signaling pathway GO:0060337 9.82 HLA-A HLA-B HLA-C
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 TLR2 TLR4 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.8 CD36 TLR2 TLR4
13 immune system process GO:0002376 9.8 CD8A HLA-A HLA-B HLA-C HLA-DRB1 TLR2
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 CD36 TLR4 TNF
15 toll-like receptor signaling pathway GO:0002224 9.77 CD36 TLR2 TLR4
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TLR2 TLR4 TNF
17 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-A HLA-B HLA-C HLA-DRB1
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.74 CD36 TLR2 TLR4
19 positive regulation of interleukin-6 production GO:0032755 9.73 CD36 TLR2 TLR4 TNF
20 cellular response to amyloid-beta GO:1904646 9.72 CD36 TLR4
21 negative regulation of interferon-gamma production GO:0032689 9.72 HLA-DRB1 TLR4
22 negative regulation of interleukin-6 production GO:0032715 9.72 TLR4 TNF
23 positive regulation of interferon-beta production GO:0032728 9.72 TLR2 TLR4
24 negative regulation of myoblast differentiation GO:0045662 9.71 CCL17 TNF
25 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
26 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.71 HLA-A HLA-B HLA-C
27 microglial cell activation GO:0001774 9.7 TLR2 TNF
28 response to fatty acid GO:0070542 9.7 CD36 TLR2
29 negative regulation of growth of symbiont in host GO:0044130 9.7 CD36 TNF
30 positive regulation of interleukin-8 production GO:0032757 9.7 TLR2 TLR4 TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR2 TLR4
32 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.69 CD36 TLR4
33 positive regulation of interleukin-12 production GO:0032735 9.69 CD36 TLR2 TLR4
34 regulation of cytokine secretion GO:0050707 9.68 TLR2 TLR4
35 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
37 T-helper 1 type immune response GO:0042088 9.67 HLA-DRB1 TLR4
38 positive regulation of T cell mediated cytotoxicity GO:0001916 9.67 HLA-A HLA-B HLA-C
39 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.66 CD36 TLR4
40 interleukin-1 beta secretion GO:0050702 9.66 CD36 TLR4
41 positive regulation of macrophage cytokine production GO:0060907 9.65 CD36 TLR4
42 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.65 CD36 TLR4
43 positive regulation of chemokine production GO:0032722 9.65 TLR2 TLR4 TNF
44 protection from natural killer cell mediated cytotoxicity GO:0042270 9.64 HLA-A HLA-B
45 cellular response to diacyl bacterial lipopeptide GO:0071726 9.62 CD36 TLR2
46 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.61 CD36 TLR2
47 cellular response to bacterial lipopeptide GO:0071221 9.6 CD36 TLR2
48 cellular response to lipoteichoic acid GO:0071223 9.58 CD36 TLR2 TLR4
49 positive regulation of blood microparticle formation GO:2000334 9.56 CD36 TNF
50 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.55 TLR2 TLR4

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 CCL17 HLA-A HLA-B HLA-C TLR4
2 Toll-like receptor binding GO:0035325 9.26 CD36 TLR2
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-C HLA-DRB1

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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