MCID: ALV002
MIFTS: 49

Alveolar Echinococcosis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 74 52 58 43 15 71
Echinococcus Multilocularis Infection 12 58 71
Echinococcosis 52 71
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

58
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD9CM 34 122.7
MeSH 43 C536591
SNOMED-CT 67 21009004
ICD10 32 B67.7
MESH via Orphanet 44 C536591
ICD10 via Orphanet 33 B67.5 B67.6 B67.7
UMLS via Orphanet 72 C0948954
Orphanet 58 ORPHA284
UMLS 71 C0013502 C0152069 C0948954

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to cholangitis and cysticercosis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Alveolar hydatid disease (AHD), is a form of echinococcosis, a disease that originates from a parasite.... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 534)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.0 TNF TLR4 HLA-DRB1 HLA-B
2 cysticercosis 30.9 TLR4 MT-ND1 MT-CO1
3 granulomatous hepatitis 30.5 TNF CD8A
4 pleurisy 30.4 TNF TLR4 TLR2
5 coenurosis 30.4 MT-ND1 MT-CO1
6 bronchopneumonia 30.3 TNF TLR4 CD8A
7 amebiasis 30.3 TNF TLR4 TLR2
8 sparganosis 30.3 MT-ND1 MT-CO1
9 acute cystitis 30.2 TNF TLR4 TLR2
10 mycobacterium tuberculosis 1 30.2 TNF TLR4 TLR2 CD8A
11 sclerosing cholangitis 30.2 TNF TLR4 HLA-DRB1 HLA-B
12 filariasis 30.2 TNF TLR4 TLR2
13 toxic shock syndrome 30.1 TNF TLR4 TLR2
14 toxoplasmosis 30.1 TNF TLR4 TLR2 HLA-DQB1
15 aspergillosis 30.0 TNF TLR4 TLR2 CCL17
16 spondylitis 30.0 TNF TAP2 HLA-C HLA-B
17 listeriosis 30.0 TNF TLR4 TLR2 CD8A
18 pulmonary tuberculosis 30.0 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
19 q fever 30.0 TNF TLR4 TLR2
20 bronchiolitis 29.9 TNF TLR4 TLR2
21 peritonitis 29.9 TNF TLR4 TLR2
22 myocarditis 29.9 TNF TLR4 HLA-DQB1 HLA-B
23 bone inflammation disease 29.8 TNF TLR4 TLR2 HLA-DRB1 CD8A
24 lung disease 29.8 TNF TLR4 TLR2 CD8A
25 plague 29.8 TNF TLR4 TLR2 CD8A
26 colitis 29.8 TNF TLR4 TLR2 HLA-DRB1
27 human immunodeficiency virus type 1 29.8 TNF HLA-C HLA-B HLA-A
28 trypanosomiasis 29.8 TNF TLR4 TLR2
29 meningitis 29.7 TNF TLR4 TLR2 HLA-B
30 parasitic protozoa infectious disease 29.7 TNF TLR4 TLR2 MT-CO1 CD8A
31 bronchitis 29.7 TNF TLR4 TLR2
32 leprosy 3 29.5 TNF TLR4 TLR2 HLA-DRB1 CD8A
33 lyme disease 29.5 TNF TLR2 HLA-DRB1 HLA-DQB1
34 leishmaniasis 29.4 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
35 pneumonia 29.4 TNF TLR4 TLR2 CD8A CCL17
36 panuveitis 29.4 TNF HLA-DRB1 HLA-DQB1 HLA-B CD8A
37 echinococcosis 29.3 TNF TLR4 TLR2 TAP2 MT-ND1 MT-CO1
38 arthritis 29.3 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
39 skin disease 29.2 TNF TLR2 HLA-C HLA-B CD8A CCL17
40 rheumatoid arthritis 29.1 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
41 polycystic echinococcosis 28.8 MT-ND1 MT-CO1 CES2 CES1
42 psoriasis 28.8 TNF TLR2 HLA-DRB1 HLA-C HLA-B HLA-A
43 inflammatory bowel disease 28.6 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
44 taeniasis 28.6 TNF TLR4 MT-ND1 MT-CO1 CES2 CES1
45 malaria 28.4 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-B
46 parasitic helminthiasis infectious disease 28.0 TNF TLR4 TLR2 MT-ND1 MT-CO1 CES2
47 cystic echinococcosis 28.0 TLR4 TLR2 TAP2 MT-ND1 MT-CO1 HLA-DRB1
48 frontal fibrosing alopecia 10.5 HLA-B HLA-A
49 budd-chiari syndrome 10.5
50 caplan's syndrome 10.5 HLA-DRB1 HLA-A

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.02 HLA-A HLA-B HLA-C
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.02 HLA-A HLA-B HLA-C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.02 HLA-C
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.02 HLA-A HLA-B HLA-C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.02 HLA-A HLA-B HLA-C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.02 HLA-A HLA-B HLA-C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.02 HLA-C
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.02 HLA-A HLA-B HLA-C
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.02 HLA-A HLA-B HLA-C
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.02 HLA-C
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.02 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CCL17 CD36 CD8A HLA-A HLA-DQB1 MT-CO1

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3
Metronidazole Approved 443-48-1 4173
4
Iodine Approved, Investigational 7553-56-2 807
5
Albendazole Approved, Vet_approved 54965-21-8 2082
6
Mebendazole Approved, Vet_approved 31431-39-7 4030
7 Benzimidazole Experimental, Investigational 51-17-2
8 Hemostatics
9 Epinephryl borate
10 cadexomer iodine
11 Anti-Infective Agents
12 Anthelmintics
13 Antiparasitic Agents
14 Antiprotozoal Agents
15 Tubulin Modulators
16 Liver Extracts
17 Antimitotic Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Exploratory Phase IV Randomized Single Blind Study Evaluating the Efficacy and Tolerability of Hemopatch in Improving Time of Hemostasis and Preventing Post-operative Complications After Hepatic Resection Unknown status NCT03323359
2 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
4 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
5 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
6 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
7 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
8 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Completed NCT03490435
9 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
10 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
11 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
12 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
13 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole
14 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Active, not recruiting NCT04271176

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole

Cochrane evidence based reviews: alveolar echinococcosis

Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

40
Liver, Lung, Brain, Testes, T Cells, Bone, Lymph Node

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 1535)
# Title Authors PMID Year
1
Portal hypertension as a result of the incomplete surgically treated advanced alveolar echinococcosis: a case description. 61
32503447 2020
2
The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis. 61
32539714 2020
3
Follow-up in hepatic alveolar echinococcosis under benzimidazole therapy using computed tomography. 61
32568942 2020
4
Hepatic alveolar echinococcosis: Comparative computed tomography study between two Chinese and two European centres. 61
32435708 2020
5
Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis. 61
32576011 2020
6
In vitro and in vivo efficacies of inhibitors of the EGFR/MEK/ERK signaling in the treatment of alveolar echinococcosis. 61
32482675 2020
7
[An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany]. 61
32512599 2020
8
Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments. 61
32550758 2020
9
Echinococcus multilocularis vesicular fluid induces the expression of immune checkpoint proteins in vitro. 61
32171024 2020
10
Prediction and Identification of Epitopes in the Emy162 Antigen of Echinococcus multilocularis. 61
32542510 2020
11
Metformin suppresses development of the Echinococcus multilocularis larval stage targeting the TOR pathway. 61
32540980 2020
12
Recent advances on innate immune pathways related to host-parasite cross-talk in cystic and alveolar echinococcosis. 61
32375891 2020
13
Auxiliary Partial Autologous Liver Transplantation for High-selective Alveolar Echinococcosis: A Proof of Concept. 61
31895337 2020
14
Assessment of Electronic Sensing Techniques for the Rapid Identification of Alveolar Echinococcosis through Exhaled Breath Analysis. 61
32392783 2020
15
Metastases of Alveolar Echinococcosis to the Skin, Pleura, Ribs, and the Xiphoid Process: A Case Report. 61
32376067 2020
16
Factors associated with Echinococcus multilocularis infection in coyotes in southern Ontario. 61
32369261 2020
17
Regulation of hepatic microRNAs in response to early stage Echinococcus multilocularis egg infection in C57BL/6 mice. 61
32442168 2020
18
Genetic diversity of Echinococcus multilocularis and Echinococcus granulosus sensu lato in Kyrgyzstan: The A2 haplotype of E. multilocularis is the predominant variant infecting humans. 61
32401754 2020
19
Anti-echinococcal activity of menthol and a novel prodrug, menthol-pentanol, against Echinococcus multilocularis. 61
32101761 2020
20
Improvement of Antialveolar Echinococcosis Efficacy of Albendazole by a Novel Nanocrystalline Formulation with Enhanced Oral Bioavailability. 61
31576751 2020
21
Long-term (35 years) cryopreservation of Echinococcus multilocularis metacestodes. 61
32364108 2020
22
Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug. 61
32338226 2020
23
Individualized biliary reconstruction techniques in autotransplantation for end-stage hepatic alveolar echinococcosis. 61
31471064 2020
24
The importance of uninterrupted albendazole treatment in patients with unresectable alveolar echinococcosis undergoing liver transplantation. 61
32277859 2020
25
Recognising the substantial burden of neglected pandemics cystic and alveolar echinococcosis. 61
32199112 2020
26
Epidemic cystic and alveolar echinococcosis in Kyrgyzstan: an analysis of national surveillance data. 61
32199126 2020
27
Genotyping Echinococcusmultilocularis in Human Alveolar Echinococcosis Patients: An EmsB Microsatellite Analysis. 61
32295095 2020
28
A new dawn in the late stage of alveolar echinococcosis "parasite cancer". 61
32344283 2020
29
Clinical, pathological and parasitological examinations of a German spaniel with alveolar echinococcosis, Germany, 2018. 61
32448547 2020
30
Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model. 61
31410870 2020
31
On the geographic genetic variants of the cestode Echinococcus multilocularis with reference to the original descriptions from Bowles et al. (1992) and Bowles and McManus (1993), and their use. 61
31843686 2020
32
Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing. 61
32282820 2020
33
Molecular characterization of human Echinococcus isolates and the first report of E. canadensis (G6/G7) and E. multilocularis from the Punjab Province of Pakistan using sequence analysis. 61
32245373 2020
34
Molecular Characterization of Echinococcus multilocularis and Echinococcus granulosus from Cysts and Formalin-Fixed Paraffin-Embedded Tissue Samples of Human Isolates in Northeastern Turkey. 61
32251614 2020
35
Cystic and alveolar echinococcosis of the hepatobiliary tract - the role of new imaging techniques for improved diagnosis. 61
32096792 2020
36
Advanced alveolar echinococcosis in a new geographic area. 61
32198509 2020
37
Disease burden of echinococcosis in Tibetan communities-A significant public health issue in an underdeveloped region of western China. 61
31811863 2020
38
[Establishment of a recombinase-aided isothermal amplification assay for nucleic acid detection of Echinococcus multilocularis and its preliminary application]. 61
32458606 2020
39
Resection of retrohepatic inferior vena cava without reconstruction in ex vivo liver resection and autotransplantation: a retrospective study. 61
32209078 2020
40
A mathematical modelling approach for treatment and control of Echinococcus multilocularis. 61
31789140 2020
41
Cystic Echinococcosis of the Breast - Diagnostic Dilemma or just a Rare Primary Localization. 61
32337894 2020
42
Species specificity preliminary evaluation of an IL-4-based test for the differential diagnosis of human echinococcosis. 61
31884696 2020
43
Contamination of wastewater with Echinococcus multilocularis - possible implications for drinking water resources in the QTP China. 61
31794889 2020
44
Automatic lesion segmentation and classification of hepatic echinococcosis using a multiscale-feature convolutional neural network. 61
31950330 2020
45
[Results of multimodal treatment of hepatic echinococcosis]. 61
32189047 2020
46
Human Alveolar Echinococcosis, Croatia. 61
31961317 2020
47
[Echinococcus multilocularis infection - six cases during two years in Sweden]. 61
32045004 2020
48
Alveolar Echinococcosis in Children. 61
32455042 2020
49
Percutaneous stenting of left hepatic vein followed by Ex vivo Liver Resection and Autotransplantation in a patient with hepatic alveolar echinococcosis with Budd-Chiari syndrome. 61
32199250 2020
50
Successful surgical management of hepatic alveolar echinococcosis by inductive therapy with albendazole - a case report. 61
31931542 2020

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 TNF TLR4 TLR2 TAP2 KLRK1 HLA-DRB1
2
Show member pathways
13.29 TNF HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
3
Show member pathways
13.24 TLR4 TLR2 TAP2 KLRK1 HLA-DRB1 HLA-DQB1
4
Show member pathways
12.92 TNF TLR4 TLR2 HLA-C HLA-B HLA-A
5
Show member pathways
12.88 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
6
Show member pathways
12.88 TNF TLR4 TLR2 TAP2 HLA-C HLA-B
7
Show member pathways
12.78 TNF TAP2 HLA-DRB1 HLA-DQB1 HLA-C HLA-B
8 12.66 TNF TLR2 TAP2 HLA-DRB1 HLA-DQB1 HLA-C
9
Show member pathways
12.53 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
10
Show member pathways
12.52 TNF TLR4 TLR2 TAP2 HLA-DRB1 HLA-DQB1
11 12.48 TNF TLR2 TAP2 CD8A
12
Show member pathways
12.48 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
13
Show member pathways
12.46 TNF KLRK1 HLA-C HLA-B HLA-A
14 12.31 TNF HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
15
Show member pathways
12.23 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
16
Show member pathways
12.2 TNF TLR4 TLR2 CD36
17 12.2 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
18 12.05 KLRK1 HLA-C HLA-B HLA-A CD8A
19 12.05 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A CD8A
20
Show member pathways
12 TLR4 TLR2 TAP2 HLA-C HLA-B HLA-A
21 11.94 TNF KLRK1 CD8A CD36
22
Show member pathways
11.9 HLA-DRB1 HLA-A CD8A
23 11.9 TNF HLA-DRB1 HLA-DQB1 CD8A CD36
24
Show member pathways
11.87 HLA-DRB1 HLA-A CD8A
25
Show member pathways
11.86 TNF TLR4 TLR2
26 11.84 TNF TLR4 TLR2
27 11.84 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
28 11.73 TNF KLRK1 CD8A
29 11.67 HLA-DRB1 HLA-DQB1 CD8A
30
Show member pathways
11.59 TNF HLA-A CD8A
31 11.55 TNF TLR4 TLR2
32 11.47 TNF TLR4 TLR2
33 11.46 TLR4 TLR2 TAP2 HLA-DRB1 HLA-DQB1 HLA-C
34 11.35 TNF TLR4 TLR2 KLRK1 CD36
35 11.16 TAP2 HLA-C HLA-B HLA-A
36 10.87 TNF CD36
37 10.54 CES2 CES1

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.38 TNF TLR4 TLR2 TAP2 MT-ND1 MT-CO1
2 integral component of membrane GO:0016021 10.28 TNF TLR4 TLR2 TAP2 MT-ND1 MT-CO1
3 endoplasmic reticulum GO:0005783 10.07 TAP2 HLA-DRB1 HLA-C HLA-B HLA-A CES2
4 Golgi apparatus GO:0005794 10.02 TLR4 TLR2 HLA-DRB1 HLA-C HLA-B HLA-A
5 integral component of plasma membrane GO:0005887 10.02 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-C
6 Golgi membrane GO:0000139 9.96 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
7 external side of plasma membrane GO:0009897 9.88 TNF TLR4 KLRK1 HLA-DRB1 CD8A CD36
8 secretory granule membrane GO:0030667 9.72 TLR2 HLA-C HLA-B
9 recycling endosome membrane GO:0055038 9.69 HLA-C HLA-B HLA-A
10 phagocytic vesicle membrane GO:0030670 9.65 TLR2 TAP2 HLA-C HLA-B HLA-A
11 endocytic vesicle membrane GO:0030666 9.63 HLA-DRB1 HLA-DQB1 CD36
12 cell surface GO:0009986 9.61 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-C
13 ER to Golgi transport vesicle membrane GO:0012507 9.55 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
14 MHC class I protein complex GO:0042612 9.54 HLA-C HLA-B HLA-A
15 MHC class I peptide loading complex GO:0042824 9.49 TAP2 HLA-A
16 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.11 TLR4 TLR2 KLRK1 HLA-C HLA-B HLA-A
2 regulation of immune response GO:0050776 9.98 KLRK1 HLA-C HLA-B HLA-A CD8A
3 adaptive immune response GO:0002250 9.98 TAP2 KLRK1 HLA-DRB1 HLA-C HLA-B HLA-A
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF TLR4 HLA-DRB1 CD36
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF TLR4 HLA-DRB1 CD36 CCL17
6 cellular response to lipopolysaccharide GO:0071222 9.96 TNF TLR4 KLRK1 CD36
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR4 TLR2 CD36
8 cellular response to interferon-gamma GO:0071346 9.89 TLR4 TLR2 CCL17
9 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR4 TLR2
10 type I interferon signaling pathway GO:0060337 9.86 HLA-C HLA-B HLA-A
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR2
12 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR4 TLR2 CD36
13 positive regulation of interleukin-6 production GO:0032755 9.84 TNF TLR4 TLR2 CD36
14 toll-like receptor signaling pathway GO:0002224 9.83 TLR4 TLR2 CD36
15 positive regulation of interleukin-6 secretion GO:2000778 9.81 TNF TLR4 TLR2
16 immune system process GO:0002376 9.81 TLR4 TLR2 TAP2 KLRK1 HLA-DRB1 HLA-C
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 TLR2
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 TLR4 TLR2 CD36
19 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR4 KLRK1 HLA-A
20 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 KLRK1 HLA-A CD36
21 positive regulation of interleukin-8 production GO:0032757 9.79 TNF TLR4 TLR2
22 positive regulation of interleukin-12 production GO:0032735 9.77 TLR4 TLR2 CD36
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TNF TLR4 KLRK1 CD36
24 positive regulation of chemokine production GO:0032722 9.75 TNF TLR4 TLR2
25 positive regulation of interleukin-8 secretion GO:2000484 9.73 TNF TLR4 TLR2
26 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 TLR4 CD36
27 detection of bacterium GO:0016045 9.72 HLA-DRB1 HLA-B HLA-A
28 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.72 TAP2 HLA-C HLA-B HLA-A CD36
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR4 TLR2
30 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TNF TLR4
31 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.71 TNF TLR4
32 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.7 TLR4 CD36
33 I-kappaB phosphorylation GO:0007252 9.7 TLR4 TLR2
34 T-helper 1 type immune response GO:0042088 9.7 TLR4 HLA-DRB1
35 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.7 TAP2 HLA-A
36 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2 CD36
37 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.69 TLR4 CD36
38 positive regulation of macrophage cytokine production GO:0060907 9.69 TLR4 CD36
39 interleukin-1 beta secretion GO:0050702 9.69 TLR4 CD36
40 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.69 HLA-C HLA-B HLA-A
41 cellular response to bacterial lipopeptide GO:0071221 9.68 TLR2 CD36
42 cellular response to diacyl bacterial lipopeptide GO:0071726 9.68 TLR2 CD36
43 protection from natural killer cell mediated cytotoxicity GO:0042270 9.67 HLA-B HLA-A
44 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.67 HLA-DRB1 HLA-DQB1
45 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 TAP2 HLA-C HLA-B HLA-A
46 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.65 TLR2 CD36
47 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.65 HLA-C HLA-B HLA-A
48 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
49 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.64 HLA-DRB1 HLA-DQB1
50 positive regulation of blood microparticle formation GO:2000334 9.61 TNF CD36

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.63 TLR4 TLR2 CD36
2 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.51 TLR4 TLR2
3 NAD(P)+ nucleosidase activity GO:0050135 9.49 TLR4 TLR2
4 MHC class II receptor activity GO:0032395 9.48 HLA-DRB1 HLA-DQB1
5 sterol esterase activity GO:0004771 9.43 CES2 CES1
6 Toll-like receptor binding GO:0035325 9.4 TLR2 CD36
7 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
8 MHC class I protein binding GO:0042288 9.33 TAP2 KLRK1 CD8A
9 methyl indole-3-acetate esterase activity GO:0080030 9.32 CES2 CES1
10 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.26 CES2 CES1
11 TAP binding GO:0046977 9.13 HLA-C HLA-B HLA-A
12 peptide antigen binding GO:0042605 9.02 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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