MCID: ALV002
MIFTS: 56

Alveolar Echinococcosis

Categories: Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 73 20 58 44 15 70
Echinococcus Multilocularis Infection 12 58 70
Echinococcosis 20 70
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

58
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to cholangitis and cysticercosis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and lung, and related phenotypes are eosinophilia and elevated erythrocyte sedimentation rate

Wikipedia : 73 Alveolar hydatid disease (AHD), is a form of echinococcosis, a disease that originates from a parasite.... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 523)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.7 TNF TLR4 HLA-DRB1 HLA-B
2 cysticercosis 30.5 TLR4 MT-CO1 CES2
3 granulomatous hepatitis 30.2 TNF CD8A
4 paragonimiasis 30.1 MT-CO1 CCL17
5 disease by infectious agent 30.0 TNF TLR4 TLR2 CD8A
6 intestinal schistosomiasis 30.0 TNF MT-CO1 CD8A
7 pulmonary tuberculosis 30.0 TNF TLR2 HLA-DRB1 HLA-DQB1
8 spondylitis 30.0 TNF TAP2 TAP1 HLA-C HLA-B
9 colitis 29.9 TNF TLR4 TLR2 HLA-DRB1
10 toxoplasmosis 29.8 TNF TLR4 TLR2 HLA-DQB1
11 bronchopneumonia 29.8 TNF TLR4 CD8A
12 pleurisy 29.8 TNF TLR4 TLR2
13 human immunodeficiency virus type 1 29.8 TNF HLA-C HLA-B HLA-A
14 myocarditis 29.8 TNF TLR4 HLA-DQB1 HLA-B
15 allergic disease 29.7 TNF TLR4 TLR2 CCL17
16 listeriosis 29.7 TNF TLR2 CD8A
17 toxic shock syndrome 29.6 TNF TLR4 TLR2
18 sclerosing cholangitis 29.6 TNF TLR4 HLA-DRB1 HLA-DQB1 HLA-B
19 peritonitis 29.6 TNF TLR4 TLR2
20 filariasis 29.6 TNF TLR4 TLR2
21 taeniasis 29.5 TNF MT-CO1 CES2 CES1 CD8A
22 polycystic echinococcosis 29.5 MT-CO1 CES2 CES1
23 hepatitis b 29.5 TNF TLR4 TLR2 HLA-DRB1
24 liver cirrhosis 29.5 TNF TLR4 TLR2 HLA-DRB1 CD8A
25 cystic echinococcosis 29.4 TLR4 TLR2 TAP2 MT-CO1 HLA-DRB1 HLA-DQB1
26 echinococcosis 29.4 TNF TLR4 TLR2 TAP2 MT-CO1 KLRK1
27 dermatitis 29.4 TNF TLR2 CD8A CCL17
28 respiratory failure 29.4 TNF TLR4 CD8A CCL17
29 klebsiella pneumonia 29.4 TNF TLR4 TLR2
30 aspergillosis 29.4 TNF TLR4 TLR2 CCL17
31 q fever 29.4 TNF TLR4 TLR2
32 panuveitis 29.3 TNF HLA-DRB1 HLA-DQB1 HLA-B CD8A
33 leishmaniasis 29.3 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
34 bronchiolitis 29.3 TNF TLR4 TLR2
35 lyme disease 29.3 TNF TLR2 HLA-DRB1 HLA-DQB1
36 bronchitis 29.3 TNF TLR4 TLR2
37 bone inflammation disease 29.3 TNF TLR4 TLR2 HLA-DRB1 CD8A
38 meningitis 29.2 TNF TLR4 TLR2 HLA-B
39 visceral leishmaniasis 29.2 TNF TLR4 TLR2 HLA-DRB1
40 lung disease 29.1 TNF TLR4 TLR2 CD8A
41 plague 29.1 TNF TLR4 TLR2 CD8A
42 thrombocytopenia 29.1 TNF TLR4 TLR2 HLA-B HLA-A
43 parasitic protozoa infectious disease 29.1 TNF TLR4 TLR2 MT-CO1 CD8A
44 mycobacterium tuberculosis 1 29.1 TNF TLR4 TLR2 CD8A
45 rheumatoid arthritis 29.1 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
46 pneumonia 29.0 TNF TLR4 TLR2 CCL17
47 multiple sclerosis 29.0 TNF TLR4 HLA-DRB1 HLA-DQB1 HLA-A CD8A
48 skin disease 29.0 TNF TLR2 HLA-C HLA-B CD8A CCL17
49 immune deficiency disease 29.0 TNF TLR2 KLRK1 HLA-DQB1 HLA-B HLA-A
50 cystic fibrosis 28.6 TNF TLR4 TLR2 TAP1 CCL17

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

Human phenotypes related to Alveolar Echinococcosis:

58 31 (show top 50) (show all 53)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001880
2 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
3 hepatic cysts 58 31 hallmark (90%) Very frequent (99-80%) HP:0001407
4 increased circulating antibody level 31 hallmark (90%) HP:0010702
5 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
6 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
7 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
8 jaundice 58 31 frequent (33%) Frequent (79-30%) HP:0000952
9 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
10 pedal edema 58 31 frequent (33%) Frequent (79-30%) HP:0010741
11 decreased liver function 58 31 frequent (33%) Frequent (79-30%) HP:0001410
12 epigastric pain 58 31 frequent (33%) Frequent (79-30%) HP:0410019
13 asthenia 58 31 frequent (33%) Frequent (79-30%) HP:0025406
14 low back pain 58 31 frequent (33%) Frequent (79-30%) HP:0003419
15 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
16 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
17 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
18 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
19 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
20 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
21 renal cyst 58 31 occasional (7.5%) Occasional (29-5%) HP:0000107
22 ectopic calcification 58 31 occasional (7.5%) Occasional (29-5%) HP:0010766
23 abnormal spleen morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0025408
24 abnormality of adrenal morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0011732
25 cholangitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0030151
26 cutaneous abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0031292
27 pulmonary cyst 58 31 occasional (7.5%) Occasional (29-5%) HP:0032445
28 abnormal sternum morphology 31 occasional (7.5%) HP:0000766
29 ataxia 58 31 very rare (1%) Very rare (<4-1%) HP:0001251
30 dysarthria 58 31 very rare (1%) Very rare (<4-1%) HP:0001260
31 increased intracranial pressure 58 31 very rare (1%) Very rare (<4-1%) HP:0002516
32 abnormal vertebral morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0003468
33 vomiting 58 31 very rare (1%) Very rare (<4-1%) HP:0002013
34 portal hypertension 58 31 very rare (1%) Very rare (<4-1%) HP:0001409
35 biliary cirrhosis 58 31 very rare (1%) Very rare (<4-1%) HP:0002613
36 vertigo 58 31 very rare (1%) Very rare (<4-1%) HP:0002321
37 liver abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0100523
38 bone cyst 58 31 very rare (1%) Very rare (<4-1%) HP:0012062
39 pancreatic cysts 58 31 very rare (1%) Very rare (<4-1%) HP:0001737
40 abnormality of mesentery morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0100016
41 aphasia 58 31 very rare (1%) Very rare (<4-1%) HP:0002381
42 hemiparesis 58 31 very rare (1%) Very rare (<4-1%) HP:0001269
43 abnormal pericardium morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0001697
44 budd-chiari syndrome 58 31 very rare (1%) Very rare (<4-1%) HP:0002639
45 intracranial cystic lesion 58 31 very rare (1%) Very rare (<4-1%) HP:0010576
46 abnormal pelvis bone morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0040163
47 abnormality of the diaphragm 58 31 very rare (1%) Very rare (<4-1%) HP:0000775
48 abnormality of bladder morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0025487
49 seizure 31 very rare (1%) HP:0001250
50 seizures 58 Very rare (<4-1%)

GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.02 HLA-A HLA-B HLA-C
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.02 HLA-A HLA-B HLA-C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.02 HLA-C
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.02 HLA-A HLA-B HLA-C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.02 HLA-A HLA-B HLA-C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.02 HLA-A HLA-B HLA-C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.02 HLA-C
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.02 HLA-A HLA-B HLA-C
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.02 HLA-A HLA-B HLA-C
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.02 HLA-C
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.02 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CCL17 CD8A HLA-A HLA-DQB1 MT-CO1 TAP1

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3
Metronidazole Approved 443-48-1 4173
4
Mebendazole Approved, Vet_approved 31431-39-7 4030
5
Albendazole Approved, Vet_approved 54965-21-8 2082
6 Benzimidazole Experimental, Investigational 51-17-2
7 Epinephryl borate
8 Hemostatics
9 Liver Extracts
10 Antiparasitic Agents
11 Tubulin Modulators
12 Antimitotic Agents
13 Antiprotozoal Agents
14 Anthelmintics
15 Anti-Infective Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Exploratory Phase IV Randomized Single Blind Study Evaluating the Efficacy and Tolerability of Hemopatch in Improving Time of Hemostasis and Preventing Post-operative Complications After Hepatic Resection Unknown status NCT03323359
2 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
3 Bile Leakage Test in Emergency Hydatid Liver Cyst Surgery Case Report Completed NCT04705961
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
5 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
6 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
7 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
8 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
9 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
10 Intracranial Hydatid Cyst: Series of 8 Cases Completed NCT04454268
11 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
12 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
13 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole
14 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Active, not recruiting NCT04271176

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albendazole

Cochrane evidence based reviews: alveolar echinococcosis

Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

40
Liver, Bone, Lung, Kidney, Heart, Skin, Spleen

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 1623)
# Title Authors PMID Year
1
Comment on "The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting With Budd-Chiari Syndrome". 61
33491984 2021
2
The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting With Budd-Chiari Syndrome. 61
33214482 2021
3
Characterization of microRNAs expressed in the cystic legion of the liver of Mus musculus perorally infected with Echinococcus multilocularis Nemuro strain. 61
33238214 2021
4
Severe hypernatremia in children after surgical resection of hepatic echinococcosis: a rare and potentially fatal complication. 61
33761926 2021
5
Rodent control programmes can integrate Echinococcus multilocularis surveillance by facilitating parasite genotyping: the case of Arvicola terrestris voles screening in France. 61
33742248 2021
6
Molecular Evidence for Local Acquisition of Human Alveolar Echinococcosis in Saskatchewan, Canada. 61
32766836 2021
7
Epidemiological and Clinical Characteristics of Alveolar Echinococcosis: An Emerging Infectious Disease in Alberta, Canada. 61
33755579 2021
8
Metastases of Alveolar Echinococcosis to the Skin, Pleura, Ribs, and the Xiphoid Process: A Case Report. 61
32376067 2021
9
Local invasion of hepatic alveolar echinococcosis should not be underestimated: Lessons learned from imaging-pathologic correlation. 61
33500218 2021
10
Alveolar Echinococcosis of the Liver with a Rare Infiltration of the Adrenal Gland. 61
33664623 2021
11
microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai. 61
33678159 2021
12
Investigating new serological and tissue markers for the follow-up of patients operated for alveolar echinococcosis. 61
33655559 2021
13
Formal Comment; Tracing the source of infection of cystic and alveolar echinococcosis, neglected parasitic infections with long latency: The shaky road of "evidence" gathering. 61
33784305 2021
14
Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis. 61
33754355 2021
15
Echinococcus granulosus sensu lato and Echinococcus multilocularis: A review. 61
33246571 2021
16
Characterizing dynamic changes of plasma cell-free Echinococcus granulosus DNA before and after cystic echinococcosis treatment initiation. 61
33383141 2021
17
Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. 61
33750964 2021
18
In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice. 61
33770336 2021
19
Relationship between hepatic grayish-white solid nodules in horses imported from Canada and larval Echinococcus multilocularis infection. 61
33692585 2021
20
The technical aspects of ex vivo hepatectomy with autotransplantation: a systematic review and meta-analysis. 61
33591451 2021
21
Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue. 61
33630840 2021
22
Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA. 61
33442815 2021
23
Assessment of a 10-year dog deworming programme on the transmission of Echinococcus multilocularis in Tibetan communities in Sichuan Province, China. 61
33220298 2021
24
Tobacco, cannabis, and liquorice: Hidden players altering albendazole metabolism in patients with hepatic alveolar echinococcosis. 61
33309328 2021
25
Emerging human alveolar echinococcosis in Hungary (2003-2018): a retrospective case series analysis from a multi-centre study. 61
33568075 2021
26
[Effects of persistent Echinococcus multilocularis infections on hepatic fibrosis in mice]. 61
33660475 2021
27
The occurrence of Echinococcus spp. in golden jackal (Canis aureus) in southwestern Hungary: Should we need to rethink its expansion? 61
33137507 2021
28
Digest the Sugar, Kill the Parasite: A New Experimental Concept in Treating Alveolar Echinococcosis. 61
32739918 2021
29
Tracing the source of infection of cystic and alveolar echinococcosis, neglected parasitic infections with long latency: The shaky road of "evidence" gathering. 61
33476336 2021
30
[Simultaneous combined radical surgery for hepatic and renal alveolar echinococcosis: an analysis of 10 clinical cases]. 61
33412635 2021
31
High endemicity of alveolar echinococcosis in Yili Prefecture, Xinjiang Autonomous Region, the People's Republic of China: Infection status in different ethnic communities and in small mammals. 61
33465089 2021
32
Co-Occurrence of Cystic and Alveolar Echinococcosis in the Liver: A Case Report. 61
33786060 2021
33
Case Report: Successful DaVinci-Assisted Major Liver Resection for Alveolar Echinococcosis. 61
33748182 2021
34
Laparoscopic hepatectomy for the treatment of hepatic alveolar echinococcosis. 61
33439119 2021
35
Hepatic alveolar echinococcosis in a child. 61
33681918 2021
36
A global assessment of Echinococcus multilocularis infections in domestic dogs: proposing a framework to overcome past methodological heterogeneity. 61
33482171 2021
37
Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats. 61
33087186 2021
38
Echinococcus multilocularis infection in horses in Poland. 61
33308759 2020
39
Relevance of Pulmonary Alveolar Echinococcosis. 61
31420182 2020
40
Distribution of alveolar echinococcosis according to environmental and geographical factors in Germany, 1992-2018. 61
32783956 2020
41
An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver. 61
33463136 2020
42
[Multimodality navigation for liver resection of complicated alveolar echinococcosis]. 61
33256296 2020
43
Spatial distribution and incidence trend of human alveolar echinococcosis in southwest Germany: increased incidence and urbanization of the disease? 61
32676946 2020
44
Prediction and Identification of Epitopes in the Emy162 Antigen of Echinococcus multilocularis. 61
32542510 2020
45
Evaluation of the prevalence of Echinococcus multilocularis in dogs that visit off-leash dog parks in southern Ontario, Canada. 61
33336543 2020
46
Combined cross-sectional and case-control study on Echinococcus multilocularis infection in pigs in Switzerland. 61
32984810 2020
47
Short communication: Efficacy of albendazole in Echinococcus multilocularis-infected mice depends on the functional immunity of the host. 61
33010287 2020
48
Rapid and Reliable Detection of Echinococcus multilocularis from Faeces Using Droplet Digital PCR. 61
33346906 2020
49
Comment on surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients. 61
32741385 2020
50
The first case of combined heart-liver transplantation in a patient with alveolar echinococcosis. 61
32789914 2020

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF TLR4 TLR2 TAP2 TAP1 KLRK1
2
Show member pathways
13.32 TLR4 TLR2 TAP2 TAP1 KLRK1 HLA-DRB1
3
Show member pathways
12.92 TNF TLR4 TLR2 HLA-C HLA-B HLA-A
4
Show member pathways
12.87 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
5
Show member pathways
12.86 TNF TLR4 TLR2 TAP2 TAP1 HLA-C
6
Show member pathways
12.76 TNF TAP2 TAP1 HLA-DRB1 HLA-DQB1 HLA-C
7 12.61 TNF TLR2 TAP2 TAP1 HLA-DRB1 HLA-DQB1
8
Show member pathways
12.53 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
9
Show member pathways
12.52 TNF TLR4 TLR2 CD8A
10 12.5 TNF TLR2 TAP2 TAP1 CD8A
11
Show member pathways
12.47 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
12
Show member pathways
12.45 TNF KLRK1 HLA-C HLA-B HLA-A
13
Show member pathways
12.36 TNF TLR4 TLR2 TAP2 TAP1 HLA-DRB1
14 12.31 TNF HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
15
Show member pathways
12.22 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
16
Show member pathways
12.2 TLR4 TLR2 TAP2 TAP1 HLA-C HLA-B
17 12.19 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
18
Show member pathways
12.18 TNF HLA-C HLA-B HLA-A
19 12.08 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A CD8A
20 12.04 KLRK1 HLA-C HLA-B HLA-A CD8A
21 11.91 TNF KLRK1 CD8A
22
Show member pathways
11.89 HLA-DRB1 HLA-A CD8A
23
Show member pathways
11.87 HLA-DRB1 HLA-A CD8A
24 11.86 TNF HLA-DRB1 HLA-DQB1 CD8A
25 11.84 TNF TLR4 TLR2
26 11.84 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
27 11.73 TNF KLRK1 CD8A
28
Show member pathways
11.71 TNF TLR4 TLR2
29 11.66 HLA-DRB1 HLA-DQB1 CD8A
30 11.63 TNF TLR4 TLR2
31
Show member pathways
11.59 TNF HLA-A CD8A
32 11.55 TNF TLR4 TLR2
33 11.52 TNF TLR4 TLR2 KLRK1
34 11.47 TNF TLR4 TLR2
35 11.46 TLR4 TLR2 TAP2 TAP1 HLA-DRB1 HLA-DQB1
36 11.36 TAP2 TAP1 CD8A
37 11.12 TAP2 TAP1 HLA-C HLA-B HLA-A
38 10.55 CES2 CES1

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.25 TNF TLR4 TLR2 TAP2 TAP1 MT-CO1
2 endoplasmic reticulum GO:0005783 10.06 TAP2 TAP1 HLA-DRB1 HLA-C HLA-B HLA-A
3 integral component of plasma membrane GO:0005887 10.06 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-C
4 endoplasmic reticulum membrane GO:0005789 10 TAP2 TAP1 HLA-DRB1 HLA-C HLA-B HLA-A
5 Golgi membrane GO:0000139 9.95 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
6 external side of plasma membrane GO:0009897 9.89 TNF TLR4 KLRK1 HLA-DRB1 CD8A
7 cell surface GO:0009986 9.86 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-C
8 secretory granule membrane GO:0030667 9.71 TLR2 HLA-C HLA-B
9 recycling endosome membrane GO:0055038 9.69 HLA-C HLA-B HLA-A
10 MHC class II protein complex GO:0042613 9.56 HLA-DRB1 HLA-DQB1
11 ER to Golgi transport vesicle membrane GO:0012507 9.55 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
12 MHC class I protein complex GO:0042612 9.54 HLA-C HLA-B HLA-A
13 MHC class I peptide loading complex GO:0042824 9.5 TAP2 TAP1 HLA-A
14 TAP complex GO:0042825 9.48 TAP2 TAP1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.35 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
16 phagocytic vesicle membrane GO:0030670 9.1 TLR2 TAP2 TAP1 HLA-C HLA-B HLA-A

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 10.05 TAP2 TAP1 HLA-C HLA-B HLA-A
2 innate immune response GO:0045087 10.03 TLR4 TLR2 KLRK1 HLA-C HLA-B HLA-A
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 TNF TLR4 HLA-DRB1 CCL17
4 regulation of immune response GO:0050776 9.91 KLRK1 HLA-C HLA-B HLA-A CD8A
5 adaptive immune response GO:0002250 9.91 TAP2 TAP1 KLRK1 HLA-DRB1 HLA-DQB1 HLA-C
6 defense response to Gram-positive bacterium GO:0050830 9.85 TNF TLR2 HLA-A
7 cellular response to interferon-gamma GO:0071346 9.85 TLR4 TLR2 CCL17
8 positive regulation of inflammatory response GO:0050729 9.85 TNF TLR4 TLR2
9 positive regulation of interleukin-6 production GO:0032755 9.84 TNF TLR4 TLR2
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF TLR4 TLR2
11 type I interferon signaling pathway GO:0060337 9.81 HLA-C HLA-B HLA-A
12 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR4 HLA-A
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.8 TAP2 TAP1 HLA-C HLA-B HLA-A
14 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR4 TLR2
15 positive regulation of chemokine production GO:0032722 9.77 TNF TLR4 TLR2
16 interferon-gamma-mediated signaling pathway GO:0060333 9.77 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 TNF TLR4 TLR2
18 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.72 TAP2 TAP1 HLA-C HLA-B HLA-A
19 positive regulation of T cell mediated cytotoxicity GO:0001916 9.7 HLA-DRB1 HLA-B HLA-A
20 immune system process GO:0002376 9.7 TLR4 TLR2 TAP2 TAP1 KLRK1 HLA-DRB1
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR4 TLR2
22 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.68 HLA-DRB1 HLA-DQB1
23 I-kappaB phosphorylation GO:0007252 9.67 TLR4 TLR2
24 detection of bacterium GO:0016045 9.67 HLA-DRB1 HLA-B HLA-A
25 peptide transport GO:0015833 9.66 TAP2 TAP1
26 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.65 TNF TLR4
27 cellular response to lipoteichoic acid GO:0071223 9.65 TLR4 TLR2
28 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.65 TAP2 TAP1 HLA-A
29 T-helper 1 type immune response GO:0042088 9.64 TLR4 HLA-DRB1
30 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.63 HLA-C HLA-B HLA-A
31 antigen processing and presentation GO:0019882 9.63 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A CD8A
32 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.62 TAP2 TAP1
33 protection from natural killer cell mediated cytotoxicity GO:0042270 9.61 HLA-B HLA-A
34 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.61 HLA-DRB1 HLA-DQB1
35 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.61 HLA-C HLA-B HLA-A
36 positive regulation of matrix metallopeptidase secretion GO:1904466 9.58 TLR4 TLR2
37 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.58 HLA-DRB1 HLA-DQB1
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.55 TLR4 TLR2
39 cytosol to ER transport GO:0046967 9.54 TAP2 TAP1
40 immune response GO:0006955 9.32 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-C

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.57 TLR4 TLR2
2 NAD(P)+ nucleosidase activity GO:0050135 9.56 TLR4 TLR2
3 MHC protein binding GO:0042287 9.55 TAP2 TAP1
4 T cell receptor binding GO:0042608 9.54 HLA-DRB1 HLA-A
5 MHC class II receptor activity GO:0032395 9.52 HLA-DRB1 HLA-DQB1
6 sterol esterase activity GO:0004771 9.51 CES2 CES1
7 TAP1 binding GO:0046978 9.49 TAP2 TAP1
8 MHC class Ib protein binding GO:0023029 9.48 TAP2 TAP1
9 peptide antigen-transporting ATPase activity GO:0015433 9.46 TAP2 TAP1
10 lipopolysaccharide receptor activity GO:0001875 9.43 TLR4 TLR2
11 peptide transmembrane transporter activity GO:1904680 9.4 TAP2 TAP1
12 methyl indole-3-acetate esterase activity GO:0080030 9.37 CES2 CES1
13 MHC class I protein binding GO:0042288 9.33 TAP2 TAP1 CD8A
14 peptide-transporting ATPase activity GO:0015440 9.32 TAP2 TAP1
15 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.26 CES2 CES1
16 peptide antigen binding GO:0042605 9.17 TAP2 TAP1 HLA-DRB1 HLA-DQB1 HLA-C HLA-B
17 TAP binding GO:0046977 9.13 HLA-C HLA-B HLA-A

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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