MCID: ALV002
MIFTS: 50

Alveolar Echinococcosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 74 52 58 43 15 71
Echinococcus Multilocularis Infection 12 58 71
Echinococcosis 52 71
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

58
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD9CM 34 122.7
MeSH 43 C536591
SNOMED-CT 67 21009004
ICD10 32 B67.6 B67.7
MESH via Orphanet 44 C536591
ICD10 via Orphanet 33 B67.5 B67.6 B67.7
UMLS via Orphanet 72 C0948954
Orphanet 58 ORPHA284
UMLS 71 C0013502 C0152069 C0948954

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to cholangitis and spondylitis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Alveolar hydatid disease (AHD), is a form of echinococcosis, a disease that originates from a parasite.... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.0 TNF TLR4 HLA-DRB1 HLA-B
2 spondylitis 30.4 TNF HLA-C HLA-B
3 pleurisy 30.4 TNF TLR4 TLR2
4 echinococcosis 30.4 TNF TLR4 TLR2 MT-CO1 KLRK1 HLA-DRB1
5 leptospirosis 30.3 TNF TLR2 HLA-DRB1
6 bronchopneumonia 30.3 TNF TLR4 CD8A
7 amebiasis 30.2 TNF TLR4 TLR2
8 acute cystitis 30.2 TNF TLR4 TLR2
9 sclerosing cholangitis 30.2 TNF TLR4 HLA-DRB1 HLA-B
10 filariasis 30.1 TNF TLR4 TLR2
11 toxoplasmosis 30.1 TNF TLR4 TLR2 HLA-DQB1
12 toxic shock syndrome 30.1 TNF TLR4 TLR2
13 mycobacterium tuberculosis 1 30.1 TNF TLR4 TLR2 CD8A
14 pulmonary tuberculosis 30.0 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
15 listeriosis 29.9 TNF TLR4 TLR2 CD8A
16 q fever 29.9 TNF TLR4 TLR2
17 myocarditis 29.9 TNF TLR4 HLA-DQB1 HLA-B
18 peritonitis 29.9 TNF TLR4 TLR2
19 aspergillosis 29.9 TNF TLR4 TLR2 CCL17
20 allergic hypersensitivity disease 29.9 TNF TLR4 TLR2 CCL17
21 bronchiolitis 29.8 TNF TLR4 TLR2
22 human immunodeficiency virus type 1 29.8 TNF HLA-C HLA-B HLA-A
23 bone inflammation disease 29.8 TNF TLR4 TLR2 HLA-DRB1 CD8A
24 lung disease 29.7 TNF TLR4 TLR2 CD8A
25 colitis 29.7 TNF TLR4 TLR2 HLA-DRB1
26 plague 29.7 TNF TLR4 TLR2 CD8A
27 meningitis 29.7 TNF TLR4 TLR2 HLA-B
28 bronchitis 29.7 TNF TLR4 TLR2
29 parasitic protozoa infectious disease 29.7 TNF TLR4 TLR2 MT-CO1 CD8A
30 trypanosomiasis 29.7 TNF TLR4 TLR2
31 lyme disease 29.6 TNF TLR2 HLA-DRB1 HLA-DQB1
32 taeniasis 29.5 TLR4 MT-CO1 CES2 CES1 CD8A
33 polycystic echinococcosis 29.5 MT-CO1 CES2 CES1
34 leprosy 3 29.5 TNF TLR4 TLR2 HLA-DRB1 CD8A
35 leishmaniasis 29.5 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1
36 panuveitis 29.4 TNF HLA-DRB1 HLA-DQB1 HLA-B CD8A
37 pneumonia 29.4 TNF TLR4 TLR2 CD8A CCL17
38 arthritis 29.3 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
39 cystic echinococcosis 29.1 TLR4 TLR2 MT-CO1 HLA-DRB1 HLA-DQB1 HLA-B
40 skin disease 28.9 TNF TLR4 TLR2 HLA-C HLA-B CD8A
41 psoriasis 28.8 TNF TLR2 HLA-DRB1 HLA-C HLA-B HLA-A
42 parasitic helminthiasis infectious disease 28.7 TNF TLR4 TLR2 MT-CO1 CES2 CES1
43 rheumatoid arthritis 28.6 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
44 malaria 28.4 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-B
45 inflammatory bowel disease 28.2 TNF TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-C
46 phenytoin or carbamazepine toxicity 10.6 HLA-B HLA-A
47 frontal fibrosing alopecia 10.5 HLA-B HLA-A
48 budd-chiari syndrome 10.5
49 cysticercosis 10.5
50 drug reaction with eosinophilia and systemic symptoms 10.5 TNF HLA-B

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.3 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.3 HLA-A HLA-B HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.3 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.3 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.3 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.3 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.3 HLA-DRB5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.3 HLA-DRB5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.3 HLA-A HLA-B HLA-C HLA-DRB5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.3 HLA-A HLA-B HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.3 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.3 HLA-A HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.3 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.3 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.3 HLA-A HLA-B HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.3 HLA-DRB5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.3 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 CCL17 CD36 CD8A HLA-DQB1 HLA-DRB5 LBR
2 renal/urinary system MP:0005367 9.17 CD36 CD8A CES1 HLA-DQB1 LBR TLR2

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3
Iodine Approved, Investigational 7553-56-2 807
4
Metronidazole Approved 443-48-1 4173
5
Mebendazole Approved, Vet_approved 31431-39-7 4030
6
Albendazole Approved, Vet_approved 54965-21-8 2082
7 Benzimidazole Experimental, Investigational 51-17-2
8 Hemostatics
9 Epinephryl borate
10 Coagulants
11 cadexomer iodine
12 Antiparasitic Agents
13 Anthelmintics
14 Anti-Infective Agents
15 Liver Extracts
16 Antimitotic Agents
17 Antiprotozoal Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Exploratory Phase IV Randomized Single Blind Study Evaluating the Efficacy and Tolerability of Hemopatch in Improving Time of Hemostasis and Preventing Post-operative Complications After Hepatic Resection Unknown status NCT03323359
2 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
3 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
4 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
5 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
6 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
9 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Recruiting NCT03289884
10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
11 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole

Cochrane evidence based reviews: alveolar echinococcosis

Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

40
Liver, Lung, Brain, Heart, Testes, Kidney, T Cells

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 1474)
# Title Authors PMID Year
1
Contamination of wastewater with Echinococcus multilocularis - possible implications for drinking water resources in the QTP China. 61
31794889 2020
2
Human Alveolar Echinococcosis, Croatia. 61
31961317 2020
3
Successful surgical management of hepatic alveolar echinococcosis by inductive therapy with albendazole - a case report. 61
31931542 2020
4
Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. 61
31567204 2020
5
Cystic and alveolar echinococcosis are two completely different diseases caused by two different species of Echinococcus parasites. comment ON: Disseminated cystic echinococcosis of Ferdinando II de' Medici, Grand Duke of Tuscany (1610-1670) by Gaeta R, Giuffra V. J infect. 2019 Sep 4. 61
31541664 2020
6
Automatic lesion segmentation and classification of hepatic echinococcosis using a multiscale-feature convolutional neural network. 61
31950330 2020
7
Rapid and label-free screening of echinococcosis serum profiles through surface-enhanced Raman spectroscopy. 61
31734712 2020
8
The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer. 61
31852926 2019
9
Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis. 61
31856063 2019
10
Recent alveolar echinococcosis cases in North America warrant further investigation. 61
31791970 2019
11
Auxiliary Partial Autologous Liver Transplantation for High-selective Alveolar Echinococcosis: A Proof of Concept. 61
31895337 2019
12
A mathematical modelling approach for treatment and control of Echinococcus multilocularis. 61
31789140 2019
13
Species specificity preliminary evaluation of an IL-4-based test for the differential diagnosis of human echinococcosis. 61
31884696 2019
14
In vitro metabolomic footprint of the Echinococcus multilocularis metacestode. 61
31857639 2019
15
In vitro efficacy of ampelopsin against Echinococcus granulosus and Echinococcus multilocularis. 61
31748438 2019
16
On the geographic genetic variants of the cestode Echinococcus multilocularis with reference to the original descriptions from Bowles et al. (1992) and Bowles and McManus (1993), and their use. 61
31843686 2019
17
Disease burden of echinococcosis in Tibetan communities-A significant public health issue in an underdeveloped region of western China. 61
31811863 2019
18
AE hepatic lesions: correlation between calcifications at CT and FDG-PET/CT metabolic activity. 61
31165442 2019
19
The local immune response during Echinococcus granulosus growth in a quantitative hepatic experimental model. 61
31873157 2019
20
Recent advances in surgical strategies for alveolar echinococcosis of the liver. 61
31768657 2019
21
Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis. 61
31725454 2019
22
"Necklace in the lung:" Multilocularis hydatid cyst mimicking left-sided massive pleural effusion. 61
31670306 2019
23
The usefulness of commercially available serological tests in the diagnosis and monitoring of treatment in patients with alveolar echinococcosis. 61
31893245 2019
24
Drug repurposing for the treatment of alveolar echinococcosis: in vitro and in vivo effects of silica nanoparticles modified with dichlorophen. 61
31397256 2019
25
Corrigendum -Epidemiological analysis of the distribution of cystic and alveolar echinococcosis in Osh Oblast in the Kyrgyz Republic, 2000-2013. 61
31190667 2019
26
Epidemiology of echinococcosis in Iran: a systematic review and meta-analysis. 61
31684882 2019
27
Frequency and clinical presentation of alveolar and cystic echinococcosis in a tertiary medical center in Germany 2004-2018: lessons from a low-prevalence area. 61
31739373 2019
28
In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes. 61
31744550 2019
29
Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century. 61
31147846 2019
30
[Diagnostics and management of intra-abdominal Echinococcus manifestation]. 61
31312861 2019
31
Compared efficacy of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions in ex-situ liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis patients. 61
31331754 2019
32
A Case of Alveolar Echinococcosis Occurring in the Hilar Bile Duct. 61
31715693 2019
33
Use of the ELISA (Em2-Em18) and Western Blotting Methods on Diagnosis of Alveolar Echinococcosis 61
31591873 2019
34
Alveolar echinococcosis in an Ontario dog resembling an hepatic abscess. 61
31597996 2019
35
Enhanced Oral Bioavailability and Anti-Echinococcosis Efficacy of Albendazole Achieved by Optimizing the "Spring" and "Parachute". 61
31613633 2019
36
Improvement of Antialveolar Echinococcosis Efficacy of Albendazole by a Novel Nanocrystalline Formulation with Enhanced Oral Bioavailability. 61
31576751 2019
37
Remnant Liver-to-Standard Liver Volume Ratio Below 40% is Safe in Ex Vivo Liver Resection and Autotransplantation. 61
30374819 2019
38
Screening for microRNA-based diagnostic markers in hepatic alveolar echinococcosis. 61
31517861 2019
39
Surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients. 61
31267889 2019
40
Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease. 61
31003201 2019
41
Outcomes of different surgical resection techniques for end-stage hepatic alveolar echinococcosis with inferior vena cava invasion. 61
30782476 2019
42
Echinococcus multilocularis inoculation induces NK cell functional decrease through high expression of NKG2A in C57BL/6 mice. 61
31500589 2019
43
First detection of Echinococcus multilocularis in environmental water sources in endemic areas using capsule filtration and molecular detection methods. 61
31174074 2019
44
Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model. 61
31410870 2019
45
The efficacy of an alternative mebendazole formulation in mice infected with Echinococcus multilocularis. 61
31082364 2019
46
Long-term retrospective assessment of a transmission hotspot for human alveolar echinococcosis in mid-west China. 61
31469833 2019
47
Individualized biliary reconstruction techniques in autotransplantation for end-stage hepatic alveolar echinococcosis. 61
31471064 2019
48
Disseminated alveolar echinococcosis in a 74-year-old woman presenting with focal seizure. 61
31451525 2019
49
Usability of Inferior Vena Cava Interposition Graft During Living Donor Liver Transplantation: Is This Approach Always Necessary? 61
31385171 2019
50
Relevance of Pulmonary Alveolar Echinococcosis. 61
31420182 2019

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TNF TLR4 TLR2 KLRK1 HLA-DRB5 HLA-DRB1
2
Show member pathways
13.35 TLR4 TLR2 KLRK1 HLA-DRB5 HLA-DRB1 HLA-DQB1
3
Show member pathways
13.3 TNF HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B
4
Show member pathways
13.15 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
5
Show member pathways
12.95 TNF TLR4 TLR2 HLA-C HLA-B HLA-A
6
Show member pathways
12.91 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
7
Show member pathways
12.9 TNF TLR4 TLR2 HLA-C HLA-B HLA-A
8
Show member pathways
12.84 TNF HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B
9 12.77 TNF TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C
10
Show member pathways
12.57 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
11
Show member pathways
12.52 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
12
Show member pathways
12.52 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
13
Show member pathways
12.48 TNF KLRK1 HLA-C HLA-B HLA-A
14
Show member pathways
12.45 TLR4 TLR2 HLA-C HLA-B HLA-A CD8A
15
Show member pathways
12.28 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
16 12.25 TNF HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B
17 12.24 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
18
Show member pathways
12.22 TNF TLR4 TLR2 CD36
19 12.06 KLRK1 HLA-C HLA-B HLA-A CD8A
20
Show member pathways
12.02 TNF TLR4 TLR2 CD36
21 11.97 TNF KLRK1 CD8A CD36
22
Show member pathways
11.92 HLA-DRB1 HLA-A CD8A
23
Show member pathways
11.89 HLA-DRB5 HLA-DRB1 HLA-DQB1
24
Show member pathways
11.89 HLA-DRB1 HLA-A CD8A
25 11.86 HLA-DRB5 HLA-DRB1 HLA-DQB1
26 11.85 TNF TLR4 TLR2
27 11.82 HLA-DRB5 HLA-DRB1 HLA-DQB1
28 11.79 TNF HLA-DRB5 HLA-DRB1 HLA-DQB1 CD8A CD36
29
Show member pathways
11.76 HLA-DRB5 HLA-DRB1 HLA-DQB1
30 11.74 TNF KLRK1 CD8A
31 11.72 HLA-DRB5 HLA-DRB1 HLA-DQB1 CD8A
32 11.7 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1
33 11.69 TNF CD36 CCL17
34 11.67 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
35
Show member pathways
11.61 TNF HLA-A CD8A
36 11.58 TNF TLR4 TLR2
37 11.5 TNF TLR4 TLR2 KLRK1 CD36
38 11.49 TNF TLR4 TLR2
39 11.46 TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C
40 11.16 HLA-C HLA-B HLA-A
41 10.89 TNF CD36
42 10.56 CES2 CES1

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.42 TNF TLR4 TLR2 MT-CO1 LBR KLRK1
2 plasma membrane GO:0005886 10.33 TNF TLR4 TLR2 KLRK1 HLA-DRB5 HLA-DRB1
3 integral component of membrane GO:0016021 10.28 TNF TLR4 TLR2 MT-CO1 LBR KLRK1
4 endoplasmic reticulum GO:0005783 10.13 LBR HLA-DRB5 HLA-DRB1 HLA-C HLA-B HLA-A
5 integral component of plasma membrane GO:0005887 10.11 TNF TLR4 TLR2 KLRK1 HLA-B HLA-A
6 Golgi apparatus GO:0005794 10.08 TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-C HLA-B
7 endosome membrane GO:0010008 9.86 TLR4 HLA-DRB5 HLA-DRB1 HLA-DQB1
8 cell surface GO:0009986 9.81 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-C
9 external side of plasma membrane GO:0009897 9.8 TNF TLR4 KLRK1 HLA-DRB1 HLA-B CD8A
10 secretory granule membrane GO:0030667 9.77 TLR2 HLA-C HLA-B
11 trans-Golgi network membrane GO:0032588 9.76 HLA-DRB5 HLA-DRB1 HLA-DQB1
12 recycling endosome membrane GO:0055038 9.74 HLA-C HLA-B HLA-A
13 transport vesicle membrane GO:0030658 9.71 HLA-DRB5 HLA-DRB1 HLA-DQB1
14 phagocytic vesicle membrane GO:0030670 9.71 TLR2 HLA-C HLA-B HLA-A
15 clathrin-coated endocytic vesicle membrane GO:0030669 9.67 HLA-DRB5 HLA-DRB1 HLA-DQB1
16 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB5 HLA-DRB1 HLA-DQB1 CD36
17 MHC class II protein complex GO:0042613 9.63 HLA-DRB5 HLA-DRB1 HLA-DQB1
18 MHC class I protein complex GO:0042612 9.5 HLA-C HLA-B HLA-A
19 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
20 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.1 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF TLR4 CD36 CCL17
2 cellular response to lipopolysaccharide GO:0071222 9.94 TNF TLR4 KLRK1 CD36
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR4 TLR2 CD36
4 regulation of immune response GO:0050776 9.89 KLRK1 HLA-C HLA-B HLA-A CD8A
5 cellular response to interferon-gamma GO:0071346 9.88 TLR4 TLR2 CCL17
6 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.87 HLA-DRB5 HLA-DRB1 HLA-DQB1
7 positive regulation of inflammatory response GO:0050729 9.86 TNF TLR4 TLR2
8 type I interferon signaling pathway GO:0060337 9.85 HLA-C HLA-B HLA-A
9 immune system process GO:0002376 9.85 TLR4 TLR2 KLRK1 HLA-DRB5 HLA-DRB1 HLA-DQB1
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 TNF TLR4 TLR2
11 defense response to Gram-positive bacterium GO:0050830 9.83 TNF TLR2 KLRK1 CD36
12 positive regulation of tumor necrosis factor production GO:0032760 9.82 TLR4 TLR2 CD36
13 positive regulation of interferon-gamma production GO:0032729 9.81 TNF TLR4 KLRK1
14 toll-like receptor signaling pathway GO:0002224 9.8 TLR4 TLR2 CD36
15 positive regulation of interleukin-6 secretion GO:2000778 9.78 TNF TLR4 TLR2
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.78 HLA-C HLA-B HLA-A CD36
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR4 TLR2
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.77 TLR4 TLR2 CD36
19 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.76 HLA-C HLA-B HLA-A
20 positive regulation of interleukin-8 production GO:0032757 9.75 TNF TLR4 TLR2
21 positive regulation of interleukin-6 production GO:0032755 9.73 TNF TLR4 TLR2 CD36
22 interferon-gamma-mediated signaling pathway GO:0060333 9.73 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
23 positive regulation of interleukin-8 secretion GO:2000484 9.71 TLR4 TLR2
24 positive regulation of interleukin-12 production GO:0032735 9.71 TLR4 TLR2 CD36
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR4 TLR2
26 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.7 TLR4 CD36
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TNF TLR4
28 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.69 TLR4 CD36
29 I-kappaB phosphorylation GO:0007252 9.69 TLR4 TLR2
30 positive regulation of chemokine production GO:0032722 9.69 TNF TLR4 TLR2
31 T-helper 1 type immune response GO:0042088 9.68 TLR4 HLA-DRB1
32 positive regulation of macrophage cytokine production GO:0060907 9.68 TLR4 CD36
33 interleukin-1 beta secretion GO:0050702 9.68 TLR4 CD36
34 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.67 TLR4 CD36
35 cellular response to diacyl bacterial lipopeptide GO:0071726 9.66 TLR2 CD36
36 cellular response to bacterial lipopeptide GO:0071221 9.65 TLR2 CD36
37 protection from natural killer cell mediated cytotoxicity GO:0042270 9.65 HLA-B HLA-A
38 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.65 HLA-DRB1 HLA-DQB1
39 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.63 HLA-DRB5 HLA-DRB1 HLA-DQB1
40 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.62 TLR2 CD36
41 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.62 HLA-DRB1 HLA-DQB1
42 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 TNF TLR4 KLRK1 CD36
43 cellular response to lipoteichoic acid GO:0071223 9.58 TLR4 TLR2 CD36
44 positive regulation of blood microparticle formation GO:2000334 9.57 TNF CD36
45 positive regulation of matrix metallopeptidase secretion GO:1904466 9.56 TLR4 TLR2
46 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.55 TLR4 TLR2
47 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-C HLA-B HLA-A
48 antigen processing and presentation GO:0019882 9.5 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
49 immune response GO:0006955 9.4 TNF TLR4 TLR2 HLA-DRB5 HLA-DRB1 HLA-DQB1

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.54 TLR4 TLR2 CD36
2 MHC class II receptor activity GO:0032395 9.4 HLA-DRB1 HLA-DQB1
3 Toll-like receptor binding GO:0035325 9.32 TLR2 CD36
4 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
5 methyl indole-3-acetate esterase activity GO:0080030 9.16 CES2 CES1
6 peptide antigen binding GO:0042605 9.1 HLA-DRB5 HLA-DRB1 HLA-DQB1 HLA-C HLA-B HLA-A
7 methylumbelliferyl-acetate deacetylase activity GO:0047374 8.96 CES2 CES1

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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