MCID: ALV002
MIFTS: 52

Alveolar Echinococcosis

Categories: Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 77 54 60 45 15 74
Echinococcus Multilocularis Infection 12 60 74
Echinococcosis 54 74
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

60
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD9CM 36 122.7
MeSH 45 C536591
SNOMED-CT 69 21009004
ICD10 34 B67.6 B67.7
MESH via Orphanet 46 C536591
ICD10 via Orphanet 35 B67.5 B67.6 B67.7
UMLS via Orphanet 75 C0948954
Orphanet 60 ORPHA284

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and cystic echinococcosis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 31.9 CCL17 HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
2 cystic echinococcosis 30.5 HLA-DRB1 MT-CO1 TLR4
3 cysticercosis 30.3 MT-CO1 TLR4
4 cholangitis 30.2 HLA-B HLA-DRB1 TNF
5 toxoplasmosis 30.1 TLR2 TLR4 TNF
6 parasitic protozoa infectious disease 29.8 MT-CO1 TLR2 TNF
7 q fever 29.7 TLR2 TLR4 TNF
8 filariasis 29.7 TLR2 TLR4 TNF
9 pneumonia 29.6 TLR2 TLR4 TNF
10 sclerosing cholangitis 29.5 HLA-B HLA-C HLA-DRB1 TNF
11 aspergillosis 29.5 CCL17 TLR2 TLR4 TNF
12 human immunodeficiency virus type 1 29.2 HLA-A HLA-B HLA-C LBR TNF
13 malaria 29.0 HLA-A HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
14 rheumatoid arthritis 28.8 HLA-B HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
15 polycystic echinococcosis 12.5
16 phenytoin or carbamazepine toxicity 10.4 HLA-A HLA-B
17 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
18 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-A HLA-B
19 idiopathic inflammatory myopathy 10.4 HLA-B HLA-DRB1
20 budd-chiari syndrome 10.4
21 taeniasis 10.4
22 drug reaction with eosinophilia and systemic symptoms 10.3 HLA-B TNF
23 microscopic polyangiitis 10.3 HLA-DRB1 TNF
24 beryllium disease 10.3 HLA-DRB1 TNF
25 paragonimiasis 10.3 CCL17 MT-CO1
26 chronic beryllium disease 10.3 HLA-DRB1 TNF
27 actinic prurigo 10.3 HLA-DRB1 TNF
28 pure red-cell aplasia 10.3 HLA-A HLA-DRB1
29 postherpetic neuralgia 10.3 HLA-A HLA-B HLA-DRB1
30 microscopic colitis 10.3 HLA-DRB1 TNF
31 pars planitis 10.3 HLA-A HLA-B HLA-DRB1
32 peanut allergy 10.3 CCL17 HLA-DRB1
33 histoplasmosis 10.3 HLA-A HLA-B HLA-DRB1
34 central nervous system vasculitis 10.2 HLA-DRB1 TNF
35 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
36 metal allergy 10.2 CD8A HLA-DRB1
37 vogt-koyanagi-harada disease 10.2 HLA-A HLA-B HLA-DRB1
38 prosthetic joint infection 10.2 TLR2 TLR4
39 colitis 10.2
40 acute disseminated encephalomyelitis 10.2 HLA-B HLA-DRB1
41 patulous eustachian tube 10.2
42 anterior uveitis 10.2 HLA-A HLA-B TLR4
43 fungal keratitis 10.2 TLR2 TLR4
44 chronic pyelonephritis 10.2 HLA-A HLA-B TLR4
45 acute cervicitis 10.2 TLR2 TLR4
46 intermediate uveitis 10.2 HLA-B TNF
47 dengue shock syndrome 10.2 HLA-A HLA-DRB1 TNF
48 palindromic rheumatism 10.2 HLA-A HLA-DRB1 TNF
49 suppurative otitis media 10.2 TLR2 TLR4
50 endometrial disease 10.2 TLR4 TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

GenomeRNAi Phenotypes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.69 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.69 HLA-A HLA-B HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.69 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.69 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.69 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.69 HLA-A HLA-B HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.69 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.69 HLA-DRB5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.69 HLA-DRB5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.69 HLA-A HLA-B HLA-C HLA-DRB5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.69 HLA-A HLA-B HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.69 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.69 HLA-A HLA-B HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.69 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.69 HLA-A HLA-B HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.69 HLA-A HLA-B HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.69 HLA-DRB5
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.69 HLA-C

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL17 CD8A HLA-DRB5 LBR MT-CO1 TLR2

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
4
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
5 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
6 Antiparasitic Agents ,Not Applicable
7 Liver Extracts Not Applicable
8 Anthelmintics ,Not Applicable
9 Anti-Infective Agents ,Not Applicable
10 cadexomer iodine
11 Antiprotozoal Agents Not Applicable
12 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Results of Comprehensive AE Management Completed NCT02509884
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
4 Periprosthetic Fracture Following Tibial Echinococcosis Completed NCT03622346 Not Applicable
5 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
6 Epi Cystic Hydatid Disease Peru Completed NCT00138346
7 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
8 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
9 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: alveolar echinococcosis

Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

42
Liver, Lung, Brain, T Cells, Testes, Bone, Pancreas

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 588)
# Title Authors Year
1
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2019
2
Echinococcus multilocularis Infection, Southern Ontario, Canada. ( 30666935 )
2019
3
Miliary Lung Metastases in Echinococcus Multilocularis Infection. ( 30928557 )
2019
4
Magnetic resonance imaging evaluation of characteristics of vascular invasion in intermediate and advanced hepatic alveolar echinococcosis. ( 31007751 )
2019
5
Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease. ( 31003201 )
2019
6
FDG-PET/MRI Imaging for the Management of Alveolar Echinococcosis: Initial Clinical Experience at a Reference Centre in Austria. ( 30851233 )
2019
7
Doughnut sign of hepatic alveolar echinococcosis on FDG PET/CT: Clinical case report. ( 30813170 )
2019
8
Outcomes of different surgical resection techniques for end-stage hepatic alveolar echinococcosis with inferior vena cava invasion. ( 30782476 )
2019
9
Hunting Poses Only a Low Risk for Alveolar Echinococcosis. ( 30761283 )
2019
10
Isolated Cerebral Alveolar Echinococcosis. ( 30740467 )
2019
11
Is ex vivo liver resection and autotransplantation a valid alternative treatment for end-stage hepatic alveolar echinococcosis in Europe? ( 30718093 )
2019
12
The role of contrast-enhanced ultrasound in the diagnosis of hepatic alveolar echinococcosis. ( 30702614 )
2019
13
Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study. ( 30615695 )
2019
14
Vena cava inferior thrombosis in the course of advanced alveolar echinococcosis. ( 30608061 )
2019
15
Ex vivo liver resection and autotransplantation versus allotransplantation for end-stage hepatic alveolar echinococcosis. ( 30496849 )
2019
16
Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study. ( 30225656 )
2019
17
Vertebral alveolar echinococcosis-a case report, systematic analysis, and review of the literature. ( 28807628 )
2018
18
Circulating cell-free DNA in patients with alveolar echinococcosis. ( 29679605 )
2018
19
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
20
Hepatic alveolar echinococcosis. ( 29653501 )
2018
21
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model. ( 29625098 )
2018
22
Primary Alveolar Echinococcosis Presenting with Simultaneous Cerebral and Craniofacial Involvement. ( 29621086 )
2018
23
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
24
Alveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center. ( 29564733 )
2018
25
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
26
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
27
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
28
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
29
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
30
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
31
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
32
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
33
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
34
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
35
Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases. ( 29232038 )
2018
36
Obstructive hydrocephalus due to intracerebral alveolar echinococcosis. ( 29228350 )
2018
37
Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging. ( 29110943 )
2018
38
Alveolar echinococcosis in Germany, 1992-2016. An update based on the newly established national AE database. ( 29090421 )
2018
39
Larval Echinococcus multilocularis infection reduces dextran sulphate sodium-induced colitis in mice by attenuating T helper type 1/type 17-mediated immune reactions. ( 29121394 )
2018
40
Analysis for genetic loci controlling protoscolex development in the Echinococcus multilocularis infection using congenic mice. ( 30030204 )
2018
41
Suppression of mouse miRNA-222-3p in response to Echinococcus multilocularis infection. ( 30212751 )
2018
42
Molecular determination of suspected alveolar echinococcosis requiring surgical treatment in human cases from Poland ( 30726664 )
2018
43
Vascular infiltration-based surgical planning in treating end-stage hepatic alveolar echinococcosis with ex vivo liver resection and autotransplantation. ( 30591376 )
2018
44
Alveolar Echinococcosis Mimicking a Hepatic Neoplasm with Lymph Node Metastasis: A Case Report. ( 30386197 )
2018
45
Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. ( 30315719 )
2018
46
Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis. ( 30278480 )
2018
47
Evaluation of the diagnostic value of the immunoblotting and ELISA tests using recombinant Em18 antigen in human alveolar echinococcosis from Xingjiang China. ( 30214538 )
2018
48
Corrigendum to "Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years" [J Hepatol 49 (2008) 72-77]. ( 30206019 )
2018
49
Comparison of [18F]Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced Ultrasound for Evaluation of Hepatic Alveolar Echinococcosis Activity. ( 30077410 )
2018
50
Ex vivo liver resection and autotransplantation as alternative to allotransplantation for end-stage hepatic alveolar echinococcosis. ( 30031886 )
2018

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
2
Show member pathways
13.24 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
3
Show member pathways
13.21 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5 TNF
4
Show member pathways
13.06 HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
5
Show member pathways
12.85 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
6
Show member pathways
12.84 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
7
Show member pathways
12.83 HLA-A HLA-B HLA-C TLR2 TLR4 TNF
8
Show member pathways
12.65 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
9
Show member pathways
12.47 HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
10
Show member pathways
12.39 HLA-A HLA-B HLA-C TNF
11
Show member pathways
12.38 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
12
Show member pathways
12.25 CD8A HLA-A HLA-B HLA-C TLR2 TLR4
13 12.16 TLR2 TLR4 TNF
14 12.16 HLA-A HLA-B HLA-C
15
Show member pathways
12.14 HLA-A HLA-B HLA-C TNF
16
Show member pathways
12.13 TLR2 TLR4 TNF
17
Show member pathways
12.1 HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
18 12.07 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5 TNF
19
Show member pathways
12.06 TLR2 TLR4 TNF
20 12.05 TLR2 TLR4 TNF
21 12.05 HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
22 12.03 HLA-A HLA-B HLA-C
23 11.98 CD8A HLA-A HLA-B HLA-C
24
Show member pathways
11.94 TLR2 TLR4 TNF
25
Show member pathways
11.92 TLR2 TLR4 TNF
26
Show member pathways
11.87 CD8A HLA-A HLA-DRB1
27
Show member pathways
11.85 CD8A HLA-A HLA-DRB1
28 11.79 TLR2 TLR4 TNF
29 11.76 CD8A HLA-DRB1 HLA-DRB5 TNF
30 11.63 CD8A HLA-DRB1 HLA-DRB5
31 11.6 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
32
Show member pathways
11.55 CD8A HLA-A TNF
33 11.51 HLA-DRB1 HLA-DRB5 TLR2 TLR4 TNF
34 11.5 TLR2 TLR4 TNF
35 11.44 CD8A HLA-DRB1 HLA-DRB5
36 11.44 TLR2 TLR4 TNF
37 11.42 TLR2 TLR4 TNF
38 11.35 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5 TLR2
39 11.13 HLA-DRB1 TNF
40 11.08 HLA-A HLA-B HLA-C

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.99 CD8A HLA-A HLA-B TLR2 TLR4 TNF
2 Golgi apparatus GO:0005794 9.93 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5 TLR2
3 external side of plasma membrane GO:0009897 9.8 CD8A HLA-DRB1 TLR4 TNF
4 Golgi membrane GO:0000139 9.8 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
5 early endosome membrane GO:0031901 9.72 HLA-A HLA-B HLA-C
6 cell surface GO:0009986 9.7 HLA-A HLA-B HLA-C HLA-DRB1 TLR2 TLR4
7 secretory granule membrane GO:0030667 9.65 HLA-B HLA-C TLR2
8 phagocytic vesicle membrane GO:0030670 9.62 HLA-A HLA-B HLA-C TLR2
9 recycling endosome membrane GO:0055038 9.61 HLA-A HLA-B HLA-C
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.57 HLA-DRB1 HLA-DRB5
11 MHC class II protein complex GO:0042613 9.54 HLA-DRB1 HLA-DRB5
12 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B HLA-C
13 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
15 membrane GO:0016020 10.26 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
16 plasma membrane GO:0005886 10.21 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
17 integral component of membrane GO:0016021 10.11 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.94 CCL17 TLR2 TLR4 TNF
2 regulation of immune response GO:0050776 9.85 CD8A HLA-A HLA-B HLA-C
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 TLR2 TLR4 TNF
4 cellular response to interferon-gamma GO:0071346 9.79 CCL17 TLR2 TLR4
5 positive regulation of inflammatory response GO:0050729 9.76 TLR2 TLR4 TNF
6 immune system process GO:0002376 9.76 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
7 type I interferon signaling pathway GO:0060337 9.75 HLA-A HLA-B HLA-C
8 positive regulation of interleukin-6 production GO:0032755 9.74 TLR2 TLR4 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TLR2 TLR4 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TLR2 TLR4 TNF
11 negative regulation of interferon-gamma production GO:0032689 9.67 HLA-DRB1 TLR4
12 negative regulation of interleukin-6 production GO:0032715 9.67 TLR4 TNF
13 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 HLA-A HLA-B HLA-C
14 positive regulation of interferon-beta production GO:0032728 9.66 TLR2 TLR4
15 negative regulation of myoblast differentiation GO:0045662 9.66 CCL17 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 TLR4
17 positive regulation of interleukin-10 production GO:0032733 9.65 TLR2 TLR4
18 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR4 TNF
19 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
20 microglial cell activation GO:0001774 9.64 TLR2 TNF
21 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.63 HLA-DRB1 HLA-DRB5
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR2 TLR4
23 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.63 HLA-A HLA-B HLA-C
24 regulation of cytokine secretion GO:0050707 9.62 TLR2 TLR4
25 I-kappaB phosphorylation GO:0007252 9.62 TLR2 TLR4
26 cellular response to lipoteichoic acid GO:0071223 9.61 TLR2 TLR4
27 positive regulation of T cell mediated cytotoxicity GO:0001916 9.61 HLA-A HLA-B HLA-C
28 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.6 TLR4 TNF
29 T-helper 1 type immune response GO:0042088 9.59 HLA-DRB1 TLR4
30 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR4 TNF
31 protection from natural killer cell mediated cytotoxicity GO:0042270 9.56 HLA-A HLA-B
32 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B HLA-C
33 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.51 TLR2 TLR4
34 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.5 HLA-A HLA-B HLA-C
35 antigen processing and presentation GO:0019882 9.43 CD8A HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5
36 immune response GO:0006955 9.32 CCL17 HLA-A HLA-B HLA-C CD8A HLA-DRB1

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 CCL17 HLA-A HLA-B HLA-C TLR4
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
3 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DRB1 HLA-DRB5

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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