MCID: ALV001
MIFTS: 36

Alveolar Periostitis

Categories: Gastrointestinal diseases, Respiratory diseases, Oral diseases

Aliases & Classifications for Alveolar Periostitis

MalaCards integrated aliases for Alveolar Periostitis:

Name: Alveolar Periostitis 12 15 73
Dry Socket 12 44
Alveolitis of Jaw 12
Alveolar Pyorrhea 73
Dry Tooth Socket 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13585
ICD10 33 M27.3 K10.3
ICD9CM 35 526.5
MeSH 44 D004368

Summaries for Alveolar Periostitis

MalaCards based summary : Alveolar Periostitis, also known as dry socket, is related to suprasellar meningioma and esophageal adenosquamous carcinoma, and has symptoms including oral manifestations An important gene associated with Alveolar Periostitis is SLC9C1 (Solute Carrier Family 9 Member C1), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Interleukin-11 Signaling Pathway. The drugs Chlorhexidine and Anti-Infective Agents have been mentioned in the context of this disorder. Related phenotypes are growth/size/body region and hematopoietic system

Related Diseases for Alveolar Periostitis

Diseases related to Alveolar Periostitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 suprasellar meningioma 10.7 MBL2 SLC9C1
2 esophageal adenosquamous carcinoma 10.6 JUN WWOX
3 osseous heteroplasia, progressive 10.4 BGLAP RUNX2
4 periosteal osteogenic sarcoma 10.4 BGLAP JUN
5 ossification of the posterior longitudinal ligament of spine 10.4 BGLAP RUNX2
6 leukoregulin 10.4 JUN PTGS2
7 glucocorticoid-induced osteoporosis 10.3 BGLAP RUNX2
8 ischemic bone disease 10.3 BGLAP RUNX2
9 acute anterolateral myocardial infarction 10.3 KANTR PLG
10 posterolateral myocardial infarction 10.3 KANTR PLG
11 facial neuralgia 10.3 KANTR PLG
12 cerebral falx meningioma 10.3 KANTR PLG
13 cerebral arteritis 10.2 KANTR PLG
14 leech infestation 10.2 KANTR PLG
15 apical myocardial infarction 10.2 KANTR PLG
16 toxic myocarditis 10.2 JUN KANTR
17 anterior cranial fossa meningioma 10.2 KANTR PLG
18 anterior spinal artery syndrome 10.2 KANTR PLG
19 anteroseptal myocardial infarction 10.2 KANTR PLG
20 brown-sequard syndrome 10.1 KANTR PLG
21 lateral medullary syndrome 10.1 KANTR PLG
22 transient global amnesia 10.1 KANTR MBL2
23 cleidocranial dysplasia 10.1 BGLAP RUNX2
24 periostitis 10.0
25 sciatic neuropathy 9.9 KANTR TNFRSF9
26 pericoronitis 9.9
27 esophageal disease 9.9 KANTR PTGS2 WWOX
28 carotid artery dissection 9.8 KANTR PLG
29 sinusitis 9.8
30 branch retinal artery occlusion 9.6 KANTR WDTC1
31 arteries, anomalies of 9.3 KANTR PLG WDTC1
32 blood coagulation disease 9.1 PLG WDTC1

Graphical network of the top 20 diseases related to Alveolar Periostitis:



Diseases related to Alveolar Periostitis

Symptoms & Phenotypes for Alveolar Periostitis

UMLS symptoms related to Alveolar Periostitis:


oral manifestations

MGI Mouse Phenotypes related to Alveolar Periostitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 TNFRSF9 WDTC1 WWOX JUN PLG PTGS2
2 hematopoietic system MP:0005397 9.76 MBL2 PLG PTGS2 RUNX2 SOSTDC1 TNFRSF9
3 homeostasis/metabolism MP:0005376 9.61 JUN MBL2 PLG PTGS2 RUNX2 SOSTDC1
4 immune system MP:0005387 9.23 JUN MBL2 PLG PTGS2 RUNX2 SOSTDC1

Drugs & Therapeutics for Alveolar Periostitis

Drugs for Alveolar Periostitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 9552079 2713
2 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
3 Anti-Infective Agents, Local Phase 4,Phase 2,Not Applicable
4 Chlorhexidine gluconate Phase 4,Phase 2
5 Dermatologic Agents Phase 4,Phase 2
6 Disinfectants Phase 4,Phase 2
7 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
9 Antitubercular Agents Phase 3
10
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
11
Lidocaine Approved, Vet_approved Phase 1, Phase 2,Phase 2,Not Applicable 137-58-6 3676
12
Bupivacaine Approved, Investigational Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
13
Epinephrine Approved, Vet_approved Phase 2,Not Applicable 51-43-4 5816
14
Racepinephrine Approved Phase 2,Not Applicable 329-65-7 838
15
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
16 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
17 Adrenergic Agents Phase 2,Not Applicable
18 Adrenergic Agonists Phase 2,Not Applicable
19 Adrenergic alpha-Agonists Phase 2,Not Applicable
20 Adrenergic beta-Agonists Phase 2,Not Applicable
21 Anesthetics, Local Phase 2,Not Applicable
22 Anti-Asthmatic Agents Phase 2,Not Applicable
23 Autonomic Agents Phase 2,Not Applicable
24 Bronchodilator Agents Phase 2,Not Applicable
25 Central Nervous System Depressants Phase 2,Not Applicable
26 Epinephryl borate Phase 2,Not Applicable
27 Mydriatics Phase 2,Not Applicable
28 Neurotransmitter Agents Phase 2,Not Applicable
29 Peripheral Nervous System Agents Phase 2,Not Applicable
30 Respiratory System Agents Phase 2,Not Applicable
31 Vasoconstrictor Agents Phase 2,Not Applicable
32 Anti-Arrhythmia Agents Phase 2
33 Diuretics, Potassium Sparing Phase 2
34 Retinol palmitate Phase 2
35 Sodium Channel Blockers Phase 2
36 retinol Nutraceutical Phase 2
37 sodium fluoride Approved Not Applicable 7681-49-4
38
Triclosan Approved, Investigational Not Applicable 3380-34-5 5564
39
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
40
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
41 Antimetabolites Not Applicable
42 Cariostatic Agents Not Applicable
43 Fluorides Not Applicable
44 Hypolipidemic Agents Not Applicable
45 Lipid Regulating Agents Not Applicable
46 Listerine Not Applicable
47 Protective Agents Not Applicable
48 Antiemetics Not Applicable
49 Anti-Inflammatory Agents Not Applicable
50 Antineoplastic Agents, Hormonal Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
3 A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan Completed NCT00199290 Phase 2 Trafermin (genetical recombination)
4 Complications After Lower Third Molar Surgery Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
5 The Influence of Intra-alveolar Application of Honey on Healing Following Extraction Recruiting NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
6 Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning Terminated NCT01878864 Phase 2 Bupivacaine lozenge;Lidocaine-adrenalin injection
7 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Not Applicable Tetracyclin ointment
8 Triclosan Toothpaste and Third Molar Surgery Completed NCT01292343 Not Applicable
9 Safety of Coronectomy vs Excision of Wisdom Teeth Completed NCT00752284 Not Applicable
10 The Use of Manuka Honey to Improve Healing After Third Molars Surgery Completed NCT02483741 Not Applicable
11 Assessment of the Operative Course in Connection With Removal of Lower Third Molars Completed NCT00805298 Not Applicable methylprednisolone;placebo;xyloplyin adrenalin;marcain adrenalin
12 Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery Active, not recruiting NCT03357484 Not Applicable

Search NIH Clinical Center for Alveolar Periostitis

Cochrane evidence based reviews: dry socket

Genetic Tests for Alveolar Periostitis

Anatomical Context for Alveolar Periostitis

Publications for Alveolar Periostitis

Articles related to Alveolar Periostitis:

# Title Authors Year
1
What is your diagnosis? Alveolar periostitis, sinusitis and malocclusion of supernumerary upper teeth. ( 1429173 )
1992
2
Radiographic diagnosis of alveolar periostitis in the molar tooth of a horse. ( 5101883 )
1971
3
Toxemia a result of alveolar periostitis. ( 21005514 )
1945

Variations for Alveolar Periostitis

Expression for Alveolar Periostitis

Search GEO for disease gene expression data for Alveolar Periostitis.

Pathways for Alveolar Periostitis

GO Terms for Alveolar Periostitis

Biological processes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.58 JUN PTGS2 TNFRSF9
2 negative regulation of cell proliferation GO:0008285 9.56 JUN PLG PTGS2 TNFRSF9
3 aging GO:0007568 9.54 BGLAP JUN PTGS2
4 skeletal system morphogenesis GO:0048705 9.48 RUNX2 WWOX
5 bone mineralization GO:0030282 9.46 BGLAP PTGS2
6 response to radiation GO:0009314 9.43 JUN PTGS2
7 response to vitamin D GO:0033280 9.32 BGLAP PTGS2
8 osteoblast development GO:0002076 9.16 BGLAP RUNX2
9 response to organic cyclic compound GO:0014070 9.13 BGLAP JUN PTGS2
10 osteoblast differentiation GO:0001649 8.8 BGLAP RUNX2 WWOX

Molecular functions related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 JUN PLG PTGS2 WWOX

Sources for Alveolar Periostitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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