MCID: ALV001
MIFTS: 40

Alveolar Periostitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Alveolar Periostitis

MalaCards integrated aliases for Alveolar Periostitis:

Name: Alveolar Periostitis 12 15 73
Dry Socket 12 44
Alveolitis of Jaw 12
Alveolar Pyorrhea 73
Dry Tooth Socket 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13585
ICD10 33 M27.3 K10.3
ICD9CM 35 526.5
MeSH 44 D004368
SNOMED-CT 68 12033006 61804006

Summaries for Alveolar Periostitis

MalaCards based summary : Alveolar Periostitis, also known as dry socket, is related to bone inflammation disease and extrinsic allergic alveolitis, and has symptoms including oral manifestations An important gene associated with Alveolar Periostitis is SLC9C1 (Solute Carrier Family 9 Member C1), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Interleukin-11 Signaling Pathway. The drugs Chlorhexidine and Disinfectants have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are growth/size/body region and hematopoietic system

Related Diseases for Alveolar Periostitis

Diseases related to Alveolar Periostitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 bone inflammation disease 10.5
2 extrinsic allergic alveolitis 10.3
3 suprasellar meningioma 10.2 MBL2 SLC9C1
4 ossification of the posterior longitudinal ligament of spine 10.2 BGLAP RUNX2
5 esophageal adenosquamous carcinoma 10.2 JUN WWOX
6 periosteal osteogenic sarcoma 10.1 BGLAP JUN
7 periostitis 10.1
8 leukoregulin 10.1 JUN PTGS2
9 osseous heteroplasia, progressive 10.1 BGLAP RUNX2
10 glucocorticoid-induced osteoporosis 10.1 BGLAP RUNX2
11 ischemic bone disease 10.1 BGLAP RUNX2
12 posterolateral myocardial infarction 10.1 KANTR PLG
13 acute anterolateral myocardial infarction 10.1 KANTR PLG
14 facial neuralgia 10.1 KANTR PLG
15 toxic myocarditis 10.1 JUN KANTR
16 cerebral falx meningioma 10.1 KANTR PLG
17 cerebral arteritis 10.1 KANTR PLG
18 leech infestation 10.1 KANTR PLG
19 apical myocardial infarction 10.1 KANTR PLG
20 anteroseptal myocardial infarction 10.0 KANTR PLG
21 anterior cranial fossa meningioma 10.0 KANTR PLG
22 transient global amnesia 10.0 KANTR MBL2
23 brown-sequard syndrome 10.0 KANTR PLG
24 anterior spinal artery syndrome 10.0 KANTR PLG
25 cleidocranial dysplasia 10.0 BGLAP RUNX2
26 lateral medullary syndrome 10.0 KANTR PLG
27 pericoronitis 10.0
28 herpes simplex 10.0
29 viral infectious disease 10.0
30 esophageal disease 10.0 KANTR PTGS2 WWOX
31 sciatic neuropathy 10.0 KANTR TNFRSF9
32 carotid artery dissection 9.9 KANTR PLG
33 sinusitis 9.9
34 branch retinal artery occlusion 9.9 KANTR WDTC1
35 arteries, anomalies of 9.8 KANTR PLG WDTC1
36 blood coagulation disease 9.7 PLG WDTC1

Graphical network of the top 20 diseases related to Alveolar Periostitis:



Diseases related to Alveolar Periostitis

Symptoms & Phenotypes for Alveolar Periostitis

UMLS symptoms related to Alveolar Periostitis:


oral manifestations

MGI Mouse Phenotypes related to Alveolar Periostitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 JUN PLG PTGS2 RUNX2 SOSTDC1 TNFRSF9
2 hematopoietic system MP:0005397 9.76 JUN MBL2 PLG PTGS2 RUNX2 SOSTDC1
3 homeostasis/metabolism MP:0005376 9.61 JUN MBL2 PLG PTGS2 RUNX2 SOSTDC1
4 immune system MP:0005387 9.23 JUN MBL2 PLG PTGS2 RUNX2 SOSTDC1

Drugs & Therapeutics for Alveolar Periostitis

Drugs for Alveolar Periostitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 2713 9552079
2 Disinfectants Phase 4,Phase 2
3 Dermatologic Agents Phase 4,Phase 2
4 Chlorhexidine gluconate Phase 4,Phase 2
5 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
6 Anti-Infective Agents, Local Phase 4,Phase 2,Not Applicable
7 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2,Not Applicable
8 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
9 Antitubercular Agents Phase 3
10
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
11
Lidocaine Approved, Vet_approved Phase 1, Phase 2,Phase 2,Not Applicable 137-58-6 3676
12
Bupivacaine Approved, Investigational Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
13
Racepinephrine Approved Phase 2,Not Applicable 329-65-7 838
14
Epinephrine Approved, Vet_approved Phase 2,Not Applicable 51-43-4 5816
15
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
16 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
17 Vasoconstrictor Agents Phase 2,Not Applicable
18 Adrenergic beta-Agonists Phase 2,Not Applicable
19 Adrenergic alpha-Agonists Phase 2,Not Applicable
20 Anesthetics, Local Phase 2,Not Applicable
21 Adrenergic Agents Phase 2,Not Applicable
22 Respiratory System Agents Phase 2,Not Applicable
23 Central Nervous System Depressants Phase 2,Not Applicable
24 Epinephryl borate Phase 2,Not Applicable
25 Autonomic Agents Phase 2,Not Applicable
26 Mydriatics Phase 2,Not Applicable
27 Adrenergic Agonists Phase 2,Not Applicable
28 Anti-Asthmatic Agents Phase 2,Not Applicable
29 Neurotransmitter Agents Phase 2,Not Applicable
30 Peripheral Nervous System Agents Phase 2,Not Applicable
31 Sympathomimetics Phase 2,Not Applicable
32 Bronchodilator Agents Phase 2,Not Applicable
33 Diuretics, Potassium Sparing Phase 2
34 Retinol palmitate Phase 2
35 Anti-Arrhythmia Agents Phase 2
36 retinol Phase 2
37 Sodium Channel Blockers Phase 2
38
Tetracycline Approved, Vet_approved Not Applicable 60-54-8 5353990
39
Triclosan Approved, Investigational Not Applicable 3380-34-5 5564
40 sodium fluoride Approved Not Applicable 7681-49-4
41
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
42
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
43
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
44
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
45
Peppermint Approved Not Applicable
46
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
47
Peppermint oil Approved, Investigational Not Applicable 8006-90-4
48
Tocopherol Approved, Investigational Not Applicable 1406-66-2 14986
49
Sorbitol Approved Not Applicable 50-70-4 5780
50
Menthol Approved Not Applicable 2216-51-5 16666

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery Recruiting NCT03741894 Phase 4 Iodoform;Chlorhexidine
3 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
4 A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan Completed NCT00199290 Phase 2 Trafermin (genetical recombination)
5 Complications After Lower Third Molar Surgery Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
6 The Influence of Intra-alveolar Application of Honey on Healing Following Extraction Recruiting NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
7 Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning Terminated NCT01878864 Phase 2 Bupivacaine lozenge;Lidocaine-adrenalin injection
8 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Not Applicable Tetracyclin ointment
9 Triclosan Toothpaste and Third Molar Surgery Completed NCT01292343 Not Applicable
10 Safety of Coronectomy vs Excision of Wisdom Teeth Completed NCT00752284 Not Applicable
11 Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. Completed NCT03711942 Not Applicable
12 The Use of Manuka Honey to Improve Healing After Third Molars Surgery Completed NCT02483741 Not Applicable
13 Assessment of the Operative Course in Connection With Removal of Lower Third Molars Completed NCT00805298 Not Applicable methylprednisolone;placebo;xyloplyin adrenalin;marcain adrenalin
14 NBF Gingival Gel Application After Impacted Lower Third Molar Surgery Active, not recruiting NCT03641482 Not Applicable NBF
15 Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery Active, not recruiting NCT03357484 Not Applicable

Search NIH Clinical Center for Alveolar Periostitis

Cochrane evidence based reviews: dry socket

Genetic Tests for Alveolar Periostitis

Anatomical Context for Alveolar Periostitis

MalaCards organs/tissues related to Alveolar Periostitis:

41
Bone

Publications for Alveolar Periostitis

Articles related to Alveolar Periostitis:

(show top 50) (show all 157)
# Title Authors Year
1
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
2
An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. ( 29104032 )
2018
3
Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. ( 29556463 )
2018
4
Dry Socket Etiology, Diagnosis, and Clinical Treatment Techniques. ( 29732309 )
2018
5
The efficacy of 1% Betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. ( 29849968 )
2018
6
Comparison of Envelope and Modified Triangular Flaps on Incidence of Dry Socket after Surgical Removal of Impacted Mandibular Third Molars: A Double-blind, Split-mouth Study. ( 30066688 )
2018
7
Platelet rich fibrin in the management of established dry socket. ( 28770156 )
2017
8
Efficacy of different methods used for dry socket prevention and risk factor analysis: A systematic review. ( 29053647 )
2017
9
Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). ( 29279679 )
2017
10
Comparative Study to Determine the efficacy of Zinc Oxide Eugenol and Alveogyl in Treatment of Dry Socket. ( 30353893 )
2017
11
Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis. ( 26946211 )
2016
12
Effectiveness of intra-alveolar chlorhexidine gel in reducing dry socket following surgical extraction of lower third molars. A pilot study. ( 27034756 )
2016
13
Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. ( 27403058 )
2016
14
Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis. ( 27499028 )
2016
15
A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction. ( 27688231 )
2016
16
RETRACTED ARTICLE: Honey Extract as Medicament for Treatment of Dry Socket: An Ancient Remedy Rediscovered-Case Series and Literature Review. ( 27752204 )
2016
17
Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. ( 25251411 )
2015
18
A retrospective study on the use of a dental dressing to reduce dry socket incidence in smokers. ( 25945758 )
2015
19
Systemic review of dry socket: aetiology, treatment, and prevention. ( 26023661 )
2015
20
Comparision between neocone, alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. ( 26028852 )
2015
21
Effect of oral contraceptive use on the incidence of dry socket in females following impacted mandibular third molar extraction: a meta-analysis. ( 26116066 )
2015
22
Efficacy of different methods used for dry socket management: A systematic review. ( 26116842 )
2015
23
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study. ( 26501007 )
2015
24
The Prevention and Management of Dry Socket: Do Antibiotics Have a Role to Play? ( 26556520 )
2015
25
Single-dose intra-alveolar chlorhexidine gel application, easier surgeries, and younger ages are associated with reduced dry socket risk. ( 24438596 )
2014
26
Dry socket: incidence, clinical features, and predisposing factors. ( 24987419 )
2014
27
Interventions for the prevention of dry socket: an evidence-based update. ( 25012325 )
2014
28
"Triple-way" approach for the treatment of dry socket: surgery and drugs plus fibrin sealant - as a biomatrix for "ultra-concentrated" platelets. ( 25312035 )
2014
29
Prevention and treatment of dry socket. ( 23579300 )
2013
30
How do I manage a patient with dry socket? ( 23763736 )
2013
31
Comparative evaluation of zinc oxide eugenol versus gelatin sponge soaked in plasma rich in growth factor in the treatment of dry socket: An initial study. ( 23853450 )
2013
32
Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. ( 23882458 )
2013
33
Dry socket following surgical removal of impacted third molar in an Iranian population: incidence and risk factors. ( 23974746 )
2013
34
The Effectiveness of GECB Pastille in Reducing Complications of Dry Socket Syndrome. ( 22577382 )
2012
35
Does chlorhexidine prevent dry socket? ( 23059928 )
2012
36
Local interventions for the management of alveolar osteitis (dry socket). ( 23235637 )
2012
37
Factors affecting incidence of dry socket: a prospective community-based study. ( 21419540 )
2011
38
Dry socket: frequency, clinical picture, and risk factors in a palestinian dental teaching center. ( 21559187 )
2011
39
Experimental dry socket: microscopic and molecular evaluation of two treatment modalities. ( 21952659 )
2011
40
The management of dry socket/alveolar osteitis. ( 22338284 )
2011
41
Evaluation of relative distribution and risk factors in patients with dry socket referring to Yazd dental clinics. ( 23372602 )
2011
42
Incidence of dry socket, alveolar infection, and postoperative pain following the extraction of erupted teeth. ( 20098964 )
2010
43
Clinical concepts of dry socket. ( 20537783 )
2010
44
Prevalence of dry socket following extraction of permanent teeth at Kathmandu University Teaching Hospital (KUTH), Dhulikhel, Kavre,Nepal: a study. ( 21209502 )
2010
45
Case report: late complication of a dry socket treatment. ( 21253516 )
2010
46
Modern concepts in understanding and management of the "dry socket" syndrome: comprehensive review of the literature. ( 18755610 )
2009
47
Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. ( 19718007 )
2009
48
Dry socket secrets. ( 18724321 )
2008
49
Dry socket: a prospective study of prevalent risk factors in a Nigerian population. ( 18940494 )
2008
50
Prevalence, clinical picture, and risk factors of dry socket in a Jordanian dental teaching center. ( 17351682 )
2007

Variations for Alveolar Periostitis

Expression for Alveolar Periostitis

Search GEO for disease gene expression data for Alveolar Periostitis.

Pathways for Alveolar Periostitis

GO Terms for Alveolar Periostitis

Biological processes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.56 JUN PLG PTGS2 TNFRSF9
2 aging GO:0007568 9.54 BGLAP JUN PTGS2
3 skeletal system morphogenesis GO:0048705 9.46 RUNX2 WWOX
4 bone mineralization GO:0030282 9.43 BGLAP PTGS2
5 response to radiation GO:0009314 9.4 JUN PTGS2
6 response to vitamin D GO:0033280 9.32 BGLAP PTGS2
7 osteoblast development GO:0002076 9.16 BGLAP RUNX2
8 response to organic cyclic compound GO:0014070 9.13 BGLAP JUN PTGS2
9 osteoblast differentiation GO:0001649 8.8 BGLAP RUNX2 WWOX

Molecular functions related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 JUN PLG PTGS2 WWOX

Sources for Alveolar Periostitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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