MCID: ALV001
MIFTS: 42

Alveolar Periostitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Alveolar Periostitis

MalaCards integrated aliases for Alveolar Periostitis:

Name: Alveolar Periostitis 12 15 74
Dry Socket 12 45
Alveolitis of Jaw 12
Alveolar Pyorrhea 74
Dry Tooth Socket 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13585
ICD9CM 36 526.5
MeSH 45 D004368
SNOMED-CT 69 12033006 61804006
ICD10 34 K10.3 M27.3

Summaries for Alveolar Periostitis

MalaCards based summary : Alveolar Periostitis, also known as dry socket, is related to bone inflammation disease and extrinsic allergic alveolitis, and has symptoms including oral manifestations An important gene associated with Alveolar Periostitis is SLC9C1 (Solute Carrier Family 9 Member C1), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Interleukin-11 Signaling Pathway. The drugs Chlorhexidine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are growth/size/body region and hematopoietic system

Related Diseases for Alveolar Periostitis

Diseases related to Alveolar Periostitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 bone inflammation disease 10.5
2 extrinsic allergic alveolitis 10.3
3 suprasellar meningioma 10.3 MBL2 SLC9C1
4 lateral myocardial infarction 10.3 HTRA2 PLG
5 ossification of the posterior longitudinal ligament of spine 10.2 BGLAP RUNX2
6 periosteal osteogenic sarcoma 10.2 BGLAP JUN
7 osseous heteroplasia, progressive 10.2 BGLAP RUNX2
8 leukoregulin 10.2 JUN PTGS2
9 glucocorticoid-induced osteoporosis 10.2 BGLAP RUNX2
10 periostitis 10.1
11 posterolateral myocardial infarction 10.1 KANTR PLG
12 ischemic bone disease 10.1 BGLAP RUNX2
13 acute anterolateral myocardial infarction 10.1 KANTR PLG
14 facial neuralgia 10.1 KANTR PLG
15 cerebral falx meningioma 10.1 KANTR PLG
16 cerebral arteritis 10.1 KANTR PLG
17 leech infestation 10.1 KANTR PLG
18 apical myocardial infarction 10.1 KANTR PLG
19 toxic myocarditis 10.1 JUN KANTR
20 anterior cranial fossa meningioma 10.1 KANTR PLG
21 transient global amnesia 10.1 KANTR MBL2
22 brown-sequard syndrome 10.1 KANTR PLG
23 cleidocranial dysplasia 10.1 BGLAP RUNX2
24 anterior spinal artery syndrome 10.1 KANTR PLG
25 lateral medullary syndrome 10.0 KANTR PLG
26 pericoronitis 10.0
27 herpes simplex 10.0
28 rapidly involuting congenital hemangioma 10.0
29 anteroseptal myocardial infarction 10.0 HTRA2 KANTR PLG
30 sciatic neuropathy 9.9 KANTR TNFRSF9
31 carotid artery dissection 9.9 KANTR PLG
32 sinusitis 9.9
33 branch retinal artery occlusion 9.8 KANTR WDTC1
34 esophageal disease 9.7 KANTR PTGS2
35 blood coagulation disease 9.7 PLG WDTC1
36 arteries, anomalies of 9.7 KANTR PLG WDTC1

Graphical network of the top 20 diseases related to Alveolar Periostitis:



Diseases related to Alveolar Periostitis

Symptoms & Phenotypes for Alveolar Periostitis

UMLS symptoms related to Alveolar Periostitis:


oral manifestations

MGI Mouse Phenotypes related to Alveolar Periostitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 HTRA2 JUN PLG PTGS2 RUNX2 SOSTDC1
2 hematopoietic system MP:0005397 9.92 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
3 homeostasis/metabolism MP:0005376 9.91 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
4 immune system MP:0005387 9.76 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
5 integument MP:0010771 9.43 HTRA2 JUN PLG PTGS2 RUNX2 TNFRSF9
6 renal/urinary system MP:0005367 9.02 MBL2 PLG PTGS2 SOSTDC1 TNFRSF9

Drugs & Therapeutics for Alveolar Periostitis

Drugs for Alveolar Periostitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 55-56-1 2713 9552079
2
Ethanol Approved Phase 4 64-17-5 702
3 Anti-Infective Agents, Local Phase 4,Phase 2,Not Applicable
4 Chlorhexidine gluconate Phase 4,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Disinfectants Phase 4,Phase 2,Not Applicable
7 Dermatologic Agents Phase 4,Phase 2,Not Applicable
8 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2,Not Applicable
9 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
10 Antitubercular Agents Phase 3
11
Amoxicillin Approved, Vet_approved Phase 1, Phase 2,Not Applicable 26787-78-0 33613
12
Lidocaine Approved, Vet_approved Phase 1, Phase 2,Phase 2,Not Applicable 137-58-6 3676
13
Epinephrine Approved, Vet_approved Phase 2,Not Applicable 51-43-4 5816
14
Bupivacaine Approved, Investigational Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
15
Racepinephrine Approved Phase 2,Not Applicable 329-65-7 838
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
17 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
18 Epinephryl borate Phase 2,Not Applicable
19 Adrenergic alpha-Agonists Phase 2,Not Applicable
20 Bronchodilator Agents Phase 2,Not Applicable
21 Adrenergic Agents Phase 2,Not Applicable
22 Respiratory System Agents Phase 2,Not Applicable
23 Anesthetics, Local Phase 2,Not Applicable
24 Neurotransmitter Agents Phase 2,Not Applicable
25 Sympathomimetics Phase 2,Not Applicable
26 Vasoconstrictor Agents Phase 2,Not Applicable
27 Adrenergic Agonists Phase 2,Not Applicable
28 Autonomic Agents Phase 2,Not Applicable
29 Anti-Asthmatic Agents Phase 2,Not Applicable
30 Adrenergic beta-Agonists Phase 2,Not Applicable
31 Peripheral Nervous System Agents Phase 2,Not Applicable
32 Central Nervous System Depressants Phase 2,Not Applicable
33 Mydriatics Phase 2,Not Applicable
34 Diuretics, Potassium Sparing Phase 2
35 Anti-Arrhythmia Agents Phase 2
36 retinol Phase 2
37 Sodium Channel Blockers Phase 2
38 Retinol palmitate Phase 2
39
Peppermint oil Approved, Investigational Not Applicable 8006-90-4
40
Peppermint Approved Not Applicable
41
Tocopherol Approved, Investigational Not Applicable 1406-66-2 14986
42
Sorbitol Approved Not Applicable 50-70-4 5780
43
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
44
Menthol Approved Not Applicable 2216-51-5 16666
45
Tetracycline Approved, Vet_approved Not Applicable 60-54-8 5353990
46 sodium fluoride Approved Not Applicable 7681-49-4
47
Triclosan Approved, Investigational Not Applicable 3380-34-5 5564
48
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
49
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
50
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery Recruiting NCT03741894 Phase 4 Iodoform;Chlorhexidine
3 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
4 The Influence of Intra-alveolar Application of Honey on Healing Following Extraction Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
5 A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan Completed NCT00199290 Phase 2 Trafermin (genetical recombination)
6 Complications After Lower Third Molar Surgery Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
7 Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning Terminated NCT01878864 Phase 2 Bupivacaine lozenge;Lidocaine-adrenalin injection
8 NBF Gingival Gel Application After Impacted Lower Third Molar Surgery Completed NCT03641482 Not Applicable NBF
9 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Not Applicable Tetracyclin ointment
10 Triclosan Toothpaste and Third Molar Surgery Completed NCT01292343 Not Applicable
11 Safety of Coronectomy vs Excision of Wisdom Teeth Completed NCT00752284 Not Applicable
12 Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. Completed NCT03711942 Not Applicable
13 The Use of Manuka Honey to Improve Healing After Third Molars Surgery Completed NCT02483741 Not Applicable
14 Assessment of the Operative Course in Connection With Removal of Lower Third Molars Completed NCT00805298 Not Applicable methylprednisolone;placebo;xyloplyin adrenalin;marcain adrenalin
15 Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery Active, not recruiting NCT03357484 Not Applicable
16 Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery Not yet recruiting NCT03844776 Not Applicable Co-Amoxiclav;Paracetamol;Chlorhexidine mouthwash;Normal saline;Amoxicillin 500 Mg;Metronidazole

Search NIH Clinical Center for Alveolar Periostitis

Cochrane evidence based reviews: dry socket

Genetic Tests for Alveolar Periostitis

Anatomical Context for Alveolar Periostitis

MalaCards organs/tissues related to Alveolar Periostitis:

42
Bone

Publications for Alveolar Periostitis

Articles related to Alveolar Periostitis:

(show top 50) (show all 160)
# Title Authors Year
1
Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study. ( 30737608 )
2019
2
Difflam™ mouthwash for dry socket. ( 30898457 )
2019
3
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
4
An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. ( 29104032 )
2018
5
Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. ( 29556463 )
2018
6
Dry Socket Etiology, Diagnosis, and Clinical Treatment Techniques. ( 29732309 )
2018
7
The efficacy of 1% Betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. ( 29849968 )
2018
8
Comparison of Envelope and Modified Triangular Flaps on Incidence of Dry Socket after Surgical Removal of Impacted Mandibular Third Molars: A Double-blind, Split-mouth Study. ( 30066688 )
2018
9
Efficacy of Alvogyl (Combination of Iodoform + Butylparaminobenzoate) and Zinc Oxide Eugenol for Dry Socket. ( 30693231 )
2018
10
Platelet rich fibrin in the management of established dry socket. ( 28770156 )
2017
11
Efficacy of different methods used for dry socket prevention and risk factor analysis: A systematic review. ( 29053647 )
2017
12
Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). ( 29279679 )
2017
13
Comparative Study to Determine the efficacy of Zinc Oxide Eugenol and Alveogyl in Treatment of Dry Socket. ( 30353893 )
2017
14
Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis. ( 26946211 )
2016
15
Effectiveness of intra-alveolar chlorhexidine gel in reducing dry socket following surgical extraction of lower third molars. A pilot study. ( 27034756 )
2016
16
Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. ( 27403058 )
2016
17
Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis. ( 27499028 )
2016
18
A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction. ( 27688231 )
2016
19
RETRACTED ARTICLE: Honey Extract as Medicament for Treatment of Dry Socket: An Ancient Remedy Rediscovered-Case Series and Literature Review. ( 27752204 )
2016
20
Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. ( 25251411 )
2015
21
A retrospective study on the use of a dental dressing to reduce dry socket incidence in smokers. ( 25945758 )
2015
22
Systemic review of dry socket: aetiology, treatment, and prevention. ( 26023661 )
2015
23
Comparision between neocone, alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. ( 26028852 )
2015
24
Effect of oral contraceptive use on the incidence of dry socket in females following impacted mandibular third molar extraction: a meta-analysis. ( 26116066 )
2015
25
Efficacy of different methods used for dry socket management: A systematic review. ( 26116842 )
2015
26
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study. ( 26501007 )
2015
27
The Prevention and Management of Dry Socket: Do Antibiotics Have a Role to Play? ( 26556520 )
2015
28
Single-dose intra-alveolar chlorhexidine gel application, easier surgeries, and younger ages are associated with reduced dry socket risk. ( 24438596 )
2014
29
Dry socket: incidence, clinical features, and predisposing factors. ( 24987419 )
2014
30
Interventions for the prevention of dry socket: an evidence-based update. ( 25012325 )
2014
31
"Triple-way" approach for the treatment of dry socket: surgery and drugs plus fibrin sealant - as a biomatrix for "ultra-concentrated" platelets. ( 25312035 )
2014
32
Prevention and treatment of dry socket. ( 23579300 )
2013
33
How do I manage a patient with dry socket? ( 23763736 )
2013
34
Comparative evaluation of zinc oxide eugenol versus gelatin sponge soaked in plasma rich in growth factor in the treatment of dry socket: An initial study. ( 23853450 )
2013
35
Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. ( 23882458 )
2013
36
Dry socket following surgical removal of impacted third molar in an Iranian population: incidence and risk factors. ( 23974746 )
2013
37
The Effectiveness of GECB Pastille in Reducing Complications of Dry Socket Syndrome. ( 22577382 )
2012
38
Does chlorhexidine prevent dry socket? ( 23059928 )
2012
39
Local interventions for the management of alveolar osteitis (dry socket). ( 23235637 )
2012
40
Factors affecting incidence of dry socket: a prospective community-based study. ( 21419540 )
2011
41
Dry socket: frequency, clinical picture, and risk factors in a palestinian dental teaching center. ( 21559187 )
2011
42
Experimental dry socket: microscopic and molecular evaluation of two treatment modalities. ( 21952659 )
2011
43
The management of dry socket/alveolar osteitis. ( 22338284 )
2011
44
Evaluation of relative distribution and risk factors in patients with dry socket referring to Yazd dental clinics. ( 23372602 )
2011
45
Incidence of dry socket, alveolar infection, and postoperative pain following the extraction of erupted teeth. ( 20098964 )
2010
46
Clinical concepts of dry socket. ( 20537783 )
2010
47
Prevalence of dry socket following extraction of permanent teeth at Kathmandu University Teaching Hospital (KUTH), Dhulikhel, Kavre,Nepal: a study. ( 21209502 )
2010
48
Case report: late complication of a dry socket treatment. ( 21253516 )
2010
49
Modern concepts in understanding and management of the "dry socket" syndrome: comprehensive review of the literature. ( 18755610 )
2009
50
Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. ( 19718007 )
2009

Variations for Alveolar Periostitis

Expression for Alveolar Periostitis

Search GEO for disease gene expression data for Alveolar Periostitis.

Pathways for Alveolar Periostitis

GO Terms for Alveolar Periostitis

Biological processes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.56 JUN PLG PTGS2 TNFRSF9
2 negative regulation of cell cycle GO:0045786 9.43 HTRA2 PTGS2
3 bone mineralization GO:0030282 9.4 BGLAP PTGS2
4 response to radiation GO:0009314 9.37 JUN PTGS2
5 response to vitamin D GO:0033280 9.32 BGLAP PTGS2
6 osteoblast development GO:0002076 9.16 BGLAP RUNX2
7 response to organic cyclic compound GO:0014070 9.13 BGLAP JUN PTGS2
8 aging GO:0007568 8.92 BGLAP HTRA2 JUN PTGS2

Sources for Alveolar Periostitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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