MCID: ALV001
MIFTS: 34

Alveolar Periostitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Alveolar Periostitis

MalaCards integrated aliases for Alveolar Periostitis:

Name: Alveolar Periostitis 12 15 71
Dry Socket 12 44
Alveolitis of Jaw 12
Alveolar Pyorrhea 71
Dry Tooth Socket 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13585
ICD9CM 34 526.5
MeSH 44 D004368
SNOMED-CT 67 251331003
ICD10 32 K10.3 M27.3
UMLS 71 C0013240 C0034219

Summaries for Alveolar Periostitis

MalaCards based summary : Alveolar Periostitis, also known as dry socket, is related to bone inflammation disease and rapidly involuting congenital hemangioma, and has symptoms including oral manifestations An important gene associated with Alveolar Periostitis is PLG (Plasminogen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Chlorhexidine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and skin, and related phenotypes are Strongly decreased CFP-tsO45G cell surface transport and Strongly decreased CFP-tsO45G cell surface transport

Related Diseases for Alveolar Periostitis

Diseases related to Alveolar Periostitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 bone inflammation disease 10.7
2 rapidly involuting congenital hemangioma 10.3
3 periostitis 10.2
4 leech infestation 10.1 PLG PF4
5 perforated corneal ulcer 10.1 PLG PF4
6 nonbacterial thrombotic endocarditis 10.1 PLG PF4
7 trigeminal neuralgia 10.1
8 pericoronitis 10.1
9 periodontitis 10.1
10 hereditary angioedema 10.1 PLG KNG1
11 hereditary angioedema with normal c1inh 10.1 PLG KNG1
12 mitral valve stenosis 10.1 PLG PF4
13 oxirane allergy 10.1 PF4 KNG1
14 angioedema 10.1 PLG KNG1
15 antithrombin iii deficiency 10.1 PLG PF4
16 occlusion precerebral artery 10.1 PLG KNG1
17 pulmonary artery disease 10.1 PLG PF4
18 intermediate coronary syndrome 10.1 PLG PF4
19 corneal neovascularization 10.0 PLG PF4
20 hair whorl 9.9
21 osteomyelitis 9.9
22 pulpitis 9.9
23 chronic apical periodontitis 9.9
24 acute apical periodontitis 9.9
25 neuritis 9.9
26 dental caries 9.9
27 herpes simplex 9.9
28 myospherulosis 9.9
29 gas gangrene 9.9
30 peripheral vascular disease 9.9 PF4 KNG1
31 blood platelet disease 9.9 PLG PF4
32 blood coagulation disease 9.9 PLG PF4 KNG1
33 hemorrhagic disease 9.8 PLG PF4 KNG1
34 cardiovascular system disease 9.8 PLG PF4 KNG1
35 hemiplegia 9.8 PLG BGLAP
36 osseous heteroplasia, progressive 9.8 KNG1 BGLAP
37 vascular disease 9.7 PLG PF4 KNG1
38 lipoprotein quantitative trait locus 9.7 PLG PF4 KNG1
39 rhinitis 9.5 KNG1 BGLAP

Graphical network of the top 20 diseases related to Alveolar Periostitis:



Diseases related to Alveolar Periostitis

Symptoms & Phenotypes for Alveolar Periostitis

UMLS symptoms related to Alveolar Periostitis:


oral manifestations

GenomeRNAi Phenotypes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.1 KIFAP3 KNG1 PRR4
2 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-2 9.1 KIFAP3 KNG1 PRR4

Drugs & Therapeutics for Alveolar Periostitis

Drugs for Alveolar Periostitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Ethanol Approved Phase 4 64-17-5 702
3 Anti-Infective Agents Phase 4
4 Anti-Infective Agents, Local Phase 4
5 Disinfectants Phase 4
6 Chlorhexidine gluconate Phase 4
7 Anti-Bacterial Agents Phase 3
8 Antibiotics, Antitubercular Phase 3
9
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
10
Metronidazole Approved Phase 2 443-48-1 4173
11
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
12
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
13 Octenidine Investigational Phase 2 71251-02-0
14 Dermatologic Agents Phase 2
15 Antiparasitic Agents Phase 2
16 Antiprotozoal Agents Phase 2
17 Pharmaceutical Solutions Phase 2
18 sodium fluoride Approved 7681-49-4
19
Triclosan Approved, Investigational 3380-34-5 5564
20
Tetracycline Approved, Vet_approved 60-54-8 5353990
21
Menthol Approved 2216-51-5 16666
22
Silicon Approved, Investigational 7440-21-3 4082203
23
Peppermint Approved
24
Peppermint oil Approved, Investigational 8006-90-4
25
Tocopherol Approved, Investigational 1406-66-2
26
Sorbitol Approved 50-70-4 5780
27
Clavulanate Approved, Vet_approved 58001-44-8 5280980
28
Acetaminophen Approved 103-90-2 1983
29
Aspirin Approved, Vet_approved 50-78-2 2244
30
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
31
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
32 Tocotrienol Investigational 6829-55-6
33 Protective Agents
34 Lipid Regulating Agents
35 Fluorides
36 Antimetabolites
37 Hypolipidemic Agents
38 Listerine
39 Anesthetics
40 Cardiac Glycosides
41 Phytosterol
42 Fluorophosphate
43 Tocotrienols
44 Propolis
45 Tocopherols
46 Bee Products
47 Carboxymethylcellulose Sodium
48 Amoxicillin-Potassium Clavulanate Combination
49 beta-Lactamase Inhibitors
50 Analgesics, Non-Narcotic

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery Recruiting NCT03741894 Phase 4 Iodoform;Chlorhexidine
3 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
4 The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
5 "Prevention of Dry Socket by Means of Single Preoperative Oral Dose of Metronidazole and Amoxicillin Compared to Conventional Therapy" Completed NCT03992144 Phase 2 Amoxicillin 500 Mg;metronidazole 400mg;metronidazol 400mg and amoxicillin 500mg
6 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
7 Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery Completed NCT01292343
8 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
9 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
10 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
11 A Comparison of Single Preoperative Dose of Co-amoxiclav Versus Postoperative Full Course of Amoxicillin/ Co-amoxiclav in Prevention of Postoperative Complications in Dentoalveolar Surgery: a Randomized Controlled Trial Recruiting NCT03844776 Co-Amoxiclav;Paracetamol;Chlorhexidine mouthwash;Normal saline;Amoxicillin 500 Mg;Metronidazole
12 Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket. Active, not recruiting NCT04476121 Nipas application
13 Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis Active, not recruiting NCT04507009

Search NIH Clinical Center for Alveolar Periostitis

Cochrane evidence based reviews: dry socket

Genetic Tests for Alveolar Periostitis

Anatomical Context for Alveolar Periostitis

MalaCards organs/tissues related to Alveolar Periostitis:

40
Bone Marrow, Skin

Publications for Alveolar Periostitis

Articles related to Alveolar Periostitis:

(show top 50) (show all 390)
# Title Authors PMID Year
1
Management of dry socket with low-level laser therapy. 61
32562076 2021
2
A Dynamic Costal Cartilage Platform Promotes Ocular Prosthetic Excursion: Preliminary Report. 61
33564583 2021
3
COVID-19 patients could be at high risk for dry socket. 61
33352433 2021
4
Retrieval of foreign body from maxillary sinus through extraction socket. 61
33462029 2021
5
Evaluation of the effects of intra-alveolar irrigation with clindamycin, rifampicin and sterile saline in alveolar osteitis treatment. 61
31991214 2020
6
The effects of photobiomodulation therapy for treatment of alveolar osteitis (Dry Socket): Systematic review and meta-analysis. 61
32919077 2020
7
Current uses of chlorhexidine for management of oral disease: a narrative review. 61
33075450 2020
8
A systematic review of the complications of high-risk third molar removal and coronectomy: development of a decision tree model and preliminary health economic analysis to assist in treatment planning. 61
32800608 2020
9
A Comparative Clinical Study between Concentrated Growth Factor and Low-Level Laser Therapy in the Management of Dry Socket. 61
32777838 2020
10
Critical analysis of methodological quality of systematic reviews and meta-analysis of antibiotics in third molar surgeries using AMSTAR 2. 61
32884898 2020
11
Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial. 61
32683390 2020
12
Microbiota of alveolar osteitis after permanent tooth extractions: A systematic review. 61
32896676 2020
13
Evaluation and comparison of anti-inflammatory properties of ibuprofen using two drug delivery systems after third molar surgery: using chitosan microspheres as a carrier for local drug delivery in to the third molar socket and through the oral route. 61
33483157 2020
14
Comparison of efficacy of ozonated water, normal saline, and povidone-iodine after surgical removal of impacted mandibular third molars: A cross-sectional study. 61
33110822 2020
15
Alveolar Osteitis: A Review of Current Concepts. 61
32348729 2020
16
Surgical techniques for the removal of mandibular wisdom teeth. 61
32712962 2020
17
Vitamin D Receptor Gene Polymorphisms and Cigarette Smoking Impact on Oral Health: A Case-Control Study. 61
32375337 2020
18
The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study. 61
32454827 2020
19
Infectious postoperative complications in oral surgery. An observational study. 61
31976046 2020
20
Comparison of Extraction Socket Healing in Non-Diabetic, Prediabetic, and Type 2 Diabetic Patients. 61
32765113 2020
21
Retraction: Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? 61
31966985 2019
22
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study. 61
30937543 2019
23
Efficacy of plasma rich in growth factor used for dry socket management: a systematic review. 61
31655828 2019
24
The influence of intra-alveolar application of honey versus Chlorhexidine rinse on the incidence of Alveolar Osteitis following molar teeth extraction. A randomized clinical parallel trial. 61
31636855 2019
25
[Research of TC-PHBHHx/β-TCP compounds for treatment of dry socket in SD rats]. 61
32274474 2019
26
Comparative Analysis of Blood Clot, Plasma Rich in Growth Factors and Platelet-Rich Fibrin Resistance to Bacteria-Induced Fibrinolysis. 61
31500263 2019
27
Post-extraction pain in the adjacent tooth after surgical extraction of the mandibular third molar. 61
31501778 2019
28
High-Throughput Sequencing Analysis of Microbial Profiles in the Dry Socket. 61
30946809 2019
29
Complications of Third Molar Extraction: A retrospective study from a tertiary healthcare centre in Oman. 61
31728221 2019
30
Mining Electronic Dental Records to Identify Dry Socket Risk Factors. 61
31349334 2019
31
Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? 61
31106135 2019
32
Difflam™ mouthwash for dry socket. 61
30898457 2019
33
Completeness of Electronic Dental Records in a Student Clinic: Retrospective Analysis. 61
30896435 2019
34
Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study. 61
30737608 2019
35
A Comparative Evaluation of the Effectiveness of Chitosan-Based Dressing and Conventional Method of Hemostasis in Patients on Oral Antithrombotic Therapy without Therapy Interruption. 61
30923426 2019
36
Are coronectomy studies being cited? A bibliometric study. 61
30324744 2019
37
A Study to Evaluate the Efficacy of Honey in the Management of Dry Socket. 61
32015642 2019
38
[Does chlorhexidine work as a preventive treatment for dry socket?] 61
30636260 2019
39
[Alveolar osteitis treatment using Holisal gel]. 61
31922512 2019
40
Extensive subcutaneous emphysema, pneumomediastinum, and pneumorrhachis following third molar surgery. 61
29752202 2018
41
Alveolar Osteitis: Patient's Compliance with Post-extraction Instructions Following Permanent Teeth Extraction. 61
30713183 2018
42
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. 61
29723658 2018
43
Persistent socket pain postenucleation and post evisceration: a systematic review. 61
29633581 2018
44
Novel Application of Platelet-Rich Fibrin as a Wound Healing Enhancement in Extraction Sockets of Patients Who Smoke. 61
30277951 2018
45
Comparison of Surgical Outcome after Impacted Third Molar Surgery Using Piezotome and a Conventional Rotary Handpiece. 61
30294165 2018
46
Versatility of platelet rich fibrin in the management of alveolar osteitis-A clinical and prospective study. 61
30191106 2018
47
Magnetic ocular prosthesis for shallow contracted socket. 61
30127178 2018
48
Comparison of Envelope and Modified Triangular Flaps on Incidence of Dry Socket after Surgical Removal of Impacted Mandibular Third Molars: A Double-blind, Split-mouth Study. 61
30066688 2018
49
Efficacy of Alvogyl (Combination of Iodoform + Butylparaminobenzoate) and Zinc Oxide Eugenol for Dry Socket. 61
30693231 2018
50
Angiogenesis and the prevention of alveolar osteitis: a review study. 61
29963489 2018

Variations for Alveolar Periostitis

Expression for Alveolar Periostitis

Search GEO for disease gene expression data for Alveolar Periostitis.

Pathways for Alveolar Periostitis

GO Terms for Alveolar Periostitis

Cellular components related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.72 PRR4 PLG PF4 KNG1 BGLAP
2 collagen-containing extracellular matrix GO:0062023 9.43 PLG PF4 KNG1
3 extracellular space GO:0005615 9.35 PRR4 PLG PF4 KNG1 BGLAP
4 spindle microtubule GO:0005876 9.16 SKA3 KIFAP3
5 platelet alpha granule lumen GO:0031093 8.8 PLG PF4 KNG1

Biological processes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 8.96 PLG KNG1
2 platelet degranulation GO:0002576 8.8 PLG PF4 KNG1

Sources for Alveolar Periostitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....