MCID: ALV001
MIFTS: 39

Alveolar Periostitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Alveolar Periostitis

MalaCards integrated aliases for Alveolar Periostitis:

Name: Alveolar Periostitis 12 15 72
Dry Socket 12 44
Alveolitis of Jaw 12
Alveolar Pyorrhea 72
Dry Tooth Socket 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13585
ICD9CM 35 526.5
MeSH 44 D004368
SNOMED-CT 68 12033006 61804006
ICD10 33 K10.3 M27.3
UMLS 72 C0013240 C0034219

Summaries for Alveolar Periostitis

MalaCards based summary : Alveolar Periostitis, also known as dry socket, is related to bone inflammation disease and suprasellar meningioma, and has symptoms including oral manifestations An important gene associated with Alveolar Periostitis is SLC9C1 (Solute Carrier Family 9 Member C1), and among its related pathways/superpathways are Hepatitis C and Hepatocellular Carcinoma and Notch-mediated HES/HEY network. The drugs Ethanol and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone and skin, and related phenotypes are growth/size/body region and hematopoietic system

Related Diseases for Alveolar Periostitis

Graphical network of the top 20 diseases related to Alveolar Periostitis:



Diseases related to Alveolar Periostitis

Symptoms & Phenotypes for Alveolar Periostitis

UMLS symptoms related to Alveolar Periostitis:


oral manifestations

MGI Mouse Phenotypes related to Alveolar Periostitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.01 HTRA2 JUN PLG PTGS2 RUNX2 SOSTDC1
2 hematopoietic system MP:0005397 9.97 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
3 homeostasis/metabolism MP:0005376 9.97 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
4 endocrine/exocrine gland MP:0005379 9.91 HTRA2 JUN PLG PTGS2 RUNX2 TNFRSF9
5 immune system MP:0005387 9.86 HTRA2 JUN MBL2 PLG PTGS2 RUNX2
6 integument MP:0010771 9.63 HTRA2 JUN PLG PTGS2 RUNX2 TNFRSF9
7 mortality/aging MP:0010768 9.56 HTRA2 JUN PLG PTGS2 RUNX2 SOSTDC1
8 renal/urinary system MP:0005367 9.02 MBL2 PLG PTGS2 SOSTDC1 TNFRSF9

Drugs & Therapeutics for Alveolar Periostitis

Drugs for Alveolar Periostitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2 Anti-Infective Agents Phase 3
3 Anti-Bacterial Agents Phase 3
4 Antibiotics, Antitubercular Phase 3
5 Antitubercular Agents Phase 3
6
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
7
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
8 Anesthetics Phase 1, Phase 2
9 sodium fluoride Approved 7681-49-4
10
Triclosan Approved, Investigational 3380-34-5 5564
11
Tetracycline Approved, Vet_approved 60-54-8 5353990
12
Sorbitol Approved 50-70-4 5780
13
Silicon Approved, Investigational 7440-21-3 4082203
14
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
15
Menthol Approved 2216-51-5 16666
16
Peppermint Approved
17
Peppermint oil Approved, Investigational 8006-90-4
18
Metronidazole Approved 443-48-1 4173
19
Clavulanate Approved, Vet_approved 58001-44-8 5280980
20
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
21
Vitamin C Approved, Nutraceutical 50-81-7 54670067 5785
22 Tocotrienol Investigational 6829-55-6
23 Cariostatic Agents
24 Lipid Regulating Agents
25 Listerine
26 Fluorides
27 Protective Agents
28 Hypolipidemic Agents
29 Antimetabolites
30 Gastrointestinal Agents
31 Cathartics
32 Cardiac Glycosides
33 Carboxymethylcellulose Sodium
34 Tocotrienols
35 Fluorophosphate
36 Tocopherols
37 Laxatives
38 Phytosterol
39 Propolis
40 Bee Products
41 Disinfectants
42 Chlorhexidine gluconate
43 Anti-Infective Agents, Local
44 Dermatologic Agents
45 Antiparasitic Agents
46 Antiprotozoal Agents
47 Amoxicillin-Potassium Clavulanate Combination
48 beta-Lactamase Inhibitors

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery Recruiting NCT03741894 Phase 4 Iodoform;Chlorhexidine
3 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
4 The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
5 "Prevention of Dry Socket by Means of Single Preoperative Oral Dose of Metronidazole and Amoxicillin Compared to Conventional Therapy" Completed NCT03992144 Phase 2 Amoxicillin 500 Mg;metronidazole 400mg;metronidazol 400mg and amoxicillin 500mg
6 Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
7 Multicentre, Double-blind, Placebo-controlled, Randomized, Parallel Group Comparison of the Analgesic Effects of Different Maxigesic Doses Versus Acetaminophen, Ibuprofen and Placebo for the Teeth Extraction Pain Withdrawn NCT01104844 Phase 2 Full Dose Strength;Quarter dose strength;Half dose strength;Acetaminophen standard dose;Ibuprofen low dose;Ibuprofen high dose;Placebo
8 Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery Completed NCT01292343
9 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
10 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
11 Post-extraction Wound Healing in Patients With Type 2 Diabetes Completed NCT01091909
12 Clinical Outcome of Dental Extractions Among Renal Transplant Recipients Completed NCT02547753
13 A Comparison of Single Preoperative Dose of Co-amoxiclav Versus Postoperative Full Course of Amoxicillin/ Co-amoxiclav in Prevention of Postoperative Complications in Dentoalveolar Surgery: a Randomized Controlled Trial Not yet recruiting NCT03844776 Co-Amoxiclav;Paracetamol;Chlorhexidine mouthwash;Normal saline;Amoxicillin 500 Mg;Metronidazole

Search NIH Clinical Center for Alveolar Periostitis

Cochrane evidence based reviews: dry socket

Genetic Tests for Alveolar Periostitis

Anatomical Context for Alveolar Periostitis

MalaCards organs/tissues related to Alveolar Periostitis:

41
Salivary Gland, Bone, Skin, Bone Marrow

Publications for Alveolar Periostitis

Articles related to Alveolar Periostitis:

(show top 50) (show all 360)
# Title Authors PMID Year
1
High-Throughput Sequencing Analysis of Microbial Profiles in the Dry Socket. 38
30946809 2019
2
Mining Electronic Dental Records to Identify Dry Socket Risk Factors. 38
31349334 2019
3
Difflam™ mouthwash for dry socket. 38
30898457 2019
4
Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? 38
31106135 2019
5
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study. 38
30937543 2019
6
Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study. 38
30737608 2019
7
Completeness of Electronic Dental Records in a Student Clinic: Retrospective Analysis. 38
30896435 2019
8
Are coronectomy studies being cited? A bibliometric study. 38
30324744 2019
9
A Comparative Evaluation of the Effectiveness of Chitosan-Based Dressing and Conventional Method of Hemostasis in Patients on Oral Antithrombotic Therapy without Therapy Interruption. 38
30923426 2019
10
[Does chlorhexidine work as a preventive treatment for dry socket?] 38
30636260 2019
11
Extensive subcutaneous emphysema, pneumomediastinum, and pneumorrhachis following third molar surgery. 38
29752202 2018
12
Alveolar Osteitis: Patient's Compliance with Post-extraction Instructions Following Permanent Teeth Extraction. 38
30713183 2018
13
Novel Application of Platelet-Rich Fibrin as a Wound Healing Enhancement in Extraction Sockets of Patients Who Smoke. 38
30277951 2018
14
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. 38
29723658 2018
15
Persistent socket pain postenucleation and post evisceration: a systematic review. 38
29633581 2018
16
Comparison of Surgical Outcome after Impacted Third Molar Surgery Using Piezotome and a Conventional Rotary Handpiece. 38
30294165 2018
17
Versatility of platelet rich fibrin in the management of alveolar osteitis-A clinical and prospective study. 38
30191106 2018
18
Magnetic ocular prosthesis for shallow contracted socket. 38
30127178 2018
19
Comparison of Envelope and Modified Triangular Flaps on Incidence of Dry Socket after Surgical Removal of Impacted Mandibular Third Molars: A Double-blind, Split-mouth Study. 38
30066688 2018
20
Efficacy of Alvogyl (Combination of Iodoform + Butylparaminobenzoate) and Zinc Oxide Eugenol for Dry Socket. 38
30693231 2018
21
Infection, Alveolar Osteitis, and Adverse Effects Using Metronidazole in Healthy Patients Undergoing Third Molar Surgery: A Meta-analysis. 38
29618877 2018
22
Angiogenesis and the prevention of alveolar osteitis: a review study. 38
29963489 2018
23
An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. 38
29104032 2018
24
The efficacy of 1% Betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. 38
29849968 2018
25
Dry Socket Etiology, Diagnosis, and Clinical Treatment Techniques. 38
29732309 2018
26
Prospective clinical study comparing intraligamentary anesthesia and inferior alveolar nerve block for extraction of posterior mandibular teeth. 38
29034443 2018
27
Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. 38
29556463 2018
28
Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. 38
28498604 2017
29
An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery. 38
29378982 2017
30
Platelet-rich Plasma and Incidence of Alveolar Osteitis in High-risk Patients Undergoing Extractions of Mandibular Molars: A Case-control Study. 38
29284959 2017
31
Efficacy of different methods used for dry socket prevention and risk factor analysis: A systematic review. 38
29053647 2017
32
Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). 38
29279679 2017
33
Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare. 38
28393367 2017
34
A novel method in the removal of impacted mandibular third molar: buccal drainage. 38
28974709 2017
35
How effective is collagen resorbable membrane placement after partially impacted mandibular third molar surgery on postoperative morbidity? A prospective randomized comparative study. 38
28982352 2017
36
Evaluation of the Need for Antibiotic Prophylaxis During Routine Intra-alveolar Dental Extractions in Healthy Patients: A Randomized Double-Blind Controlled Trial. 38
28865815 2017
37
Concomitant "Ear Bleed and Styloid Fracture": An Unusual Complication of Impacted Mandibular Third Molar Removal. 38
28751946 2017
38
Antibiotic treatment to prevent postextraction complications: a monocentric, randomized clinical trial. Preliminary outcomes. 38
28569454 2017
39
Influence of Qualification and Practice Settings of Dental Practitioners on Antimicrobial Prescribing in Delhi and National Capital Region, India. 38
28781493 2017
40
Comparative Study to Determine the efficacy of Zinc Oxide Eugenol and Alveogyl in Treatment of Dry Socket. 38
30353893 2017
41
Platelet rich fibrin in the management of established dry socket. 38
28770156 2017
42
Healing of extraction socket following local application of simvastatin: A split mouth prospective study. 38
28706784 2017
43
[Consequences of impacted wisdom teeth extraction on the periodontal environment of second molars. A pilot study]. 38
28343833 2017
44
Influence of secondary wound healing after mandibular third molar coronectomy. 38
27771163 2017
45
Repercussions of intraalveolar placement of combination of 0.2% chlorhexidine & 10 Mg metronidazole gel on the occurrence of dry sockets- A randomized control trial. 38
28210450 2017
46
Piezosurgery versus Rotatory Osteotomy in Mandibular Impacted Third Molar Extraction. 38
28713729 2017
47
Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? 38
27746007 2016
48
The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis. 38
29328639 2016
49
[Comparison of minimally invasive extraction and traditional method in the extraction of impacted mandibular third molar]. 38
28116438 2016
50
A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction. 38
27688231 2016

Variations for Alveolar Periostitis

Expression for Alveolar Periostitis

Search GEO for disease gene expression data for Alveolar Periostitis.

Pathways for Alveolar Periostitis

GO Terms for Alveolar Periostitis

Biological processes related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell death GO:0010942 9.46 PTGS2 HTRA2
2 negative regulation of cell proliferation GO:0008285 9.46 TNFRSF9 PTGS2 PLG JUN
3 negative regulation of cell cycle GO:0045786 9.43 PTGS2 HTRA2
4 bone mineralization GO:0030282 9.4 PTGS2 BGLAP
5 response to radiation GO:0009314 9.37 PTGS2 JUN
6 response to vitamin D GO:0033280 9.32 PTGS2 BGLAP
7 osteoblast development GO:0002076 9.26 RUNX2 BGLAP
8 response to organic cyclic compound GO:0014070 9.13 PTGS2 JUN BGLAP
9 aging GO:0007568 8.92 PTGS2 JUN HTRA2 BGLAP

Molecular functions related to Alveolar Periostitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.62 PLG HTRA2

Sources for Alveolar Periostitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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