MCID: ALV005
MIFTS: 55

Alveolar Soft Part Sarcoma

Categories: Genetic diseases, Rare diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Alveolar Soft Part Sarcoma

MalaCards integrated aliases for Alveolar Soft Part Sarcoma:

Name: Alveolar Soft Part Sarcoma 57 12 76 53 59 37 29 15 73
Asps 57 53 59
Sarcoma, Alveolar Soft Part 44 40
Alveolar Soft-Part Sarcoma 57 13
Childhood Alveolar Soft Part Sarcoma 12
Pediatric Alveolar Soft Part Sarcoma 12
Childhood Alveolar Soft-Part Sarcoma 73
Adult Alveolar Soft Part Sarcoma 12
Adult Alveolar Soft-Part Sarcoma 73
Alveolar Soft Tissue Sarcoma 59
Sarcoma Alveolar Soft Part 55

Characteristics:

Orphanet epidemiological data:

59
alveolar soft tissue sarcoma
Age of onset: All ages;

HPO:

32
alveolar soft part sarcoma:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 57 606243
Disease Ontology 12 DOID:4239
MeSH 44 D018234
Orphanet 59 ORPHA163699
UMLS via Orphanet 74 C0206657
MESH via Orphanet 45 D018234
ICD10 via Orphanet 34 C49.9
MedGen 42 C0206657
KEGG 37 H00051
SNOMED-CT via HPO 69 124975008

Summaries for Alveolar Soft Part Sarcoma

NIH Rare Diseases : 53 Alveolar soft part sarcoma (ASPS) is a rare, slow-growing soft tissue sarcoma. Although it has been described in a variety of locations, it most commonly develops on the lower extremities in adults and in the head and neck region of children. ASPS generally presents as a soft, pain-less lump that is often not associated with any additional signs and symptoms. In many cases, the condition is not diagnosed until the affected person develops symptoms of metastasis to other sites such as the lungs, bones, central nervous system and/or liver. The underlying cause of ASPS is poorly understood. Most cases occur sporadically in people with no family history of the condition. ASPS is generally treated with surgery; radiation therapy and/or chemotherapy may be considered if the tumor returns.

MalaCards based summary : Alveolar Soft Part Sarcoma, also known as asps, is related to granular cell tumor and chordoma. An important gene associated with Alveolar Soft Part Sarcoma is ASPSCR1 (ASPSCR1, UBX Domain Containing Tether For SLC2A4), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are alveolar soft part sarcoma and homeostasis/metabolism

OMIM : 57 Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clinical behavior (Lieberman et al., 1989; Ordonez, 1999). The typical histology of ASPS shows well-defined nests of cells with abundant pink cytoplasm. The loss of central cohesion produces a pseudoalveolar appearance (Ladanyi et al., 2001). (606243)

Disease Ontology : 12 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

Wikipedia : 76 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft-tissue sarcoma, that grows... more...

Related Diseases for Alveolar Soft Part Sarcoma

Diseases related to Alveolar Soft Part Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 granular cell tumor 30.9 DES ENO2 VIM
2 chordoma 30.6 DES MET VIM
3 perivascular epithelioid cell tumor 30.6 DES SYP VIM
4 connective tissue benign neoplasm 30.2 ENO2 SYP
5 rhabdomyosarcoma 28.1 DES ENO2 MB MET MYF6 MYOD1
6 cervical alveolar soft part sarcoma 12.6
7 vulvar alveolar soft part sarcoma 12.6
8 sarcoma 11.2
9 renal cell carcinoma, xp11-associated 11.0 ASPSCR1 TFE3
10 giant cell myocarditis 10.9 DES MB
11 infantile digital fibromatosis 10.9 DES VIM
12 malignant triton tumor 10.9 DES MB
13 lymphangiomatosis 10.9 DES VIM
14 angiolipoma 10.9 DES VIM
15 spindle cell lipoma 10.9 DES VIM
16 parachordoma 10.9 DES VIM
17 cervical polyp 10.9 DES MYOD1
18 gallbladder sarcoma 10.9 DES MYOD1
19 myofibroma 10.9 DES MB
20 syringocystadenoma papilliferum 10.9 DES VIM
21 benign metastasizing leiomyoma 10.9 DES VIM
22 bilateral retinoblastoma 10.9 DES MB
23 biphasic synovial sarcoma 10.8 DES VIM
24 malignant ectomesenchymoma 10.8 DES ENO2
25 ectomesenchymoma 10.8 DES ENO2
26 bednar tumor 10.8 ENO2 VIM
27 horner's syndrome 10.8 DES MYOD1
28 congenital fibrosarcoma 10.8 DES VIM
29 syringoma 10.8 DES VIM
30 pleomorphic rhabdomyosarcoma 10.8 MB MYOD1
31 malignant fibrous histiocytoma of bone 10.8 DES MYOD1
32 kidney rhabdoid cancer 10.8 ENO2 MB
33 juvenile xanthogranuloma 10.8 DES VIM
34 ependymoblastoma 10.8 MET VIM
35 primary hepatic neuroendocrine carcinoma 10.8 SYP VIM
36 adult fibrosarcoma 10.7 MB MYOD1
37 pleomorphic liposarcoma 10.7 DES VIM
38 rhabdoid meningioma 10.7 SYP VIM
39 ovarian small cell carcinoma 10.7 DES SYP
40 doxorubicin induced cardiomyopathy 10.7 DES MET
41 chordoid meningioma 10.7 SYP VIM
42 ureter small cell carcinoma 10.7 ENO2 SYP
43 malignant sertoli cell tumor 10.7 ENO2 SYP
44 urinary bladder small cell neuroendocrine carcinoma 10.7 ENO2 SYP
45 auditory system cancer 10.7 ENO2 SYP
46 sinonasal undifferentiated carcinoma 10.7 ENO2 SYP
47 sensory organ benign neoplasm 10.7 ENO2 SYP
48 reticulum cell sarcoma 10.7 DES VIM
49 gallbladder small cell carcinoma 10.7 ENO2 SYP
50 pancreatic somatostatinoma 10.7 ENO2 SYP

Graphical network of the top 20 diseases related to Alveolar Soft Part Sarcoma:



Diseases related to Alveolar Soft Part Sarcoma

Symptoms & Phenotypes for Alveolar Soft Part Sarcoma

Clinical features from OMIM:

606243

Human phenotypes related to Alveolar Soft Part Sarcoma:

32
# Description HPO Frequency HPO Source Accession
1 alveolar soft part sarcoma 32 HP:0012218

MGI Mouse Phenotypes related to Alveolar Soft Part Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ADAM9 DES ECM1 MB MET MLH1
2 mortality/aging MP:0010768 10.03 ADAM9 DES ECM1 MB MET MLH1
3 neoplasm MP:0002006 9.63 ADAM9 MET MLH1 MYF6 MYOD1 TCF3
4 normal MP:0002873 9.5 ADAM9 MET MYF6 MYOD1 SYP TCF3
5 respiratory system MP:0005388 9.17 VIM ENO2 MB MET MLH1 MYF6

Drugs & Therapeutics for Alveolar Soft Part Sarcoma

Drugs for Alveolar Soft Part Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Dacarbazine Approved, Investigational Phase 3,Phase 2 4342-03-4 5351166
5
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
6
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
9
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
10
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
11
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
12
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
13
Cyproheptadine Approved Phase 3 129-03-3 2913
14
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
15
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
16 Alkylating Agents Phase 3,Phase 2,Phase 1
17 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
18 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
20
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Anti-Infective Agents Phase 3,Phase 2
23 Antimitotic Agents Phase 3,Phase 2
24 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
25 Antirheumatic Agents Phase 3,Phase 2
26 Etoposide phosphate Phase 3,Phase 2
27 Immunosuppressive Agents Phase 3,Phase 2
28 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
29 Anti-Allergic Agents Phase 3
30 Antipruritics Phase 3
31 Dermatologic Agents Phase 3
32 Gastrointestinal Agents Phase 3
33 Histamine Antagonists Phase 3
34 Histamine H1 Antagonists Phase 3
35
Histamine Phosphate Phase 3 51-74-1 65513
36 Neurotransmitter Agents Phase 3
37 Serotonin Agents Phase 3
38 Serotonin Antagonists Phase 3
39
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
40
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
41
Everolimus Approved Phase 2 159351-69-6 6442177
42
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
43
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
44
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
45
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
46
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
47
Pembrolizumab Approved Phase 2 1374853-91-4
48
Gemcitabine Approved Phase 2 95058-81-4 60750
49
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
50
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
4 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
5 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
6 A Phase III Trial of Anlotinib in Metastatic or Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma and Synovial Sarcoma Recruiting NCT03016819 Phase 3 AL 3818;Dacarbazine
7 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
8 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
9 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
10 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
11 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
13 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
14 Phase 2 Study in Patients With MiT Tumors Completed NCT00557609 Phase 2 ARQ 197
15 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
16 Treatment of Patients With RAD001 With Progressive Sarcoma Completed NCT00767819 Phase 2 Everolimus
17 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
18 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
19 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
20 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
21 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
22 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
23 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
24 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
25 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
26 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
27 Atezolizumab in Treating Patients With Newly Diagnosed and Metastatic Alveolar Soft Part Sarcoma That Cannot Be Removed by Surgery Recruiting NCT03141684 Phase 2 Atezolizumab
28 Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas Recruiting NCT02636725 Phase 2 Axitinib;Pembrolizumab
29 Sunitinib or Cediranib for Alveolar Soft Part Sarcoma Recruiting NCT01391962 Phase 2 Cediranib;Sunitinib
30 Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors Recruiting NCT02867592 Phase 2 Cabozantinib S-malate
31 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
32 A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS) Active, not recruiting NCT01337401 Phase 2 Cediranib;Placebo
33 Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma Active, not recruiting NCT00942877 Phase 2 AZD2171
34 CREATE: Cross-tumoral Phase 2 With Crizotinib Active, not recruiting NCT01524926 Phase 2 Crizotinib (PF-02341066)
35 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib
36 Pazopanib for Metastatic Alveolar Soft Part Sarcoma Terminated NCT02113826 Phase 2 Pazopanib
37 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
38 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
39 Vaccine Trial for Clear Cell Sarcoma, Pediatric Renal Cell Carcinoma, Alveolar Soft Part Sarcoma and Children With Stage IV Melanoma Active, not recruiting NCT00258687 Phase 1
40 Collection of Alveolar Soft Part Sarcoma and Blood Specimens for Research Completed NCT00340353
41 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
42 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Alveolar Soft Part Sarcoma

Cochrane evidence based reviews: sarcoma, alveolar soft part

Genetic Tests for Alveolar Soft Part Sarcoma

Genetic tests related to Alveolar Soft Part Sarcoma:

# Genetic test Affiliating Genes
1 Alveolar Soft Part Sarcoma 29 ASPSCR1

Anatomical Context for Alveolar Soft Part Sarcoma

MalaCards organs/tissues related to Alveolar Soft Part Sarcoma:

41
Bone, Lung, Liver, Tongue, Cervix, Brain, Breast

Publications for Alveolar Soft Part Sarcoma

Articles related to Alveolar Soft Part Sarcoma:

(show top 50) (show all 483)
# Title Authors Year
1
Fine needle aspiration of alveolar soft part sarcoma in a child: Cytomorphological clues for the surgical pathologist. ( 29661735 )
2018
2
Alveolar Soft Part Sarcoma Presenting as Hypervascular Adrenal Metastasis. ( 29398970 )
2018
3
Alveolar soft part sarcoma in children and young adults: A report of 69 cases. ( 29350467 )
2018
4
Orbital alveolar soft part sarcoma: A report of 8 cases and review of the literature. ( 29285193 )
2018
5
Alveolar soft part sarcoma: Clinical presentation, treatment, and outcome in a series of 13 patients. ( 29625801 )
2018
6
Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy. ( 29710505 )
2018
7
Brain metastatic alveolar soft-part sarcoma: Clinicopathological profiles, management and outcomes. ( 29113207 )
2017
8
Alveolar soft part sarcoma with multiple brain and lung metastases in pregnancy: A case report and literature review. ( 29145339 )
2017
9
Surgical management and outcome of spinal alveolar soft part sarcoma (ASPA): a case series of five patients and literature review. ( 28166791 )
2017
10
Metastatic Alveolar Soft Part Sarcoma of the Spinal Cord: A Case Report and Review of Literature. ( 28450230 )
2017
11
Exploring the Histogenesis and Diagnostic Strategy Using Immunoassay and RT-PCR in Alveolar Soft Part Sarcoma. ( 28766250 )
2017
12
Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. ( 28754721 )
2017
13
Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma. ( 28945796 )
2017
14
Alveolar soft-part sarcoma of the mediastinum: A case report. ( 28321306 )
2017
15
Alveolar soft part sarcoma with brain metastases. ( 28413551 )
2017
16
Recurrent alveolar soft part sarcoma of the uterine cervix. ( 28599591 )
2017
17
Malignant perivascular epithelioid cell tumor of the oropharynx with strong TFE3 expression mimicking alveolar soft part sarcoma: a case report and review of the literature. ( 29208563 )
2017
18
Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. ( 29095301 )
2017
19
Advanced alveolar soft part sarcoma responds to apatinib. ( 28679123 )
2017
20
Alveolar soft part sarcoma: the new primary intracranial malignancy : A case report and review of the literature. ( 28744773 )
2017
21
Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. ( 27696380 )
2017
22
Rare Case Report of Alveolar Soft Part Sarcoma of the Orbit. ( 28546729 )
2017
23
Alveolar soft part sarcoma of the forearm. ( 29618868 )
2017
24
Alveolar soft part sarcoma occurring in the penis of a 3-year-old boy: A rare case report. ( 29137020 )
2017
25
Laryngeal alveolar soft part sarcoma: A case report of a rare malignancy in an atypical location. ( 28131550 )
2017
26
Alveolar soft part sarcoma: A case report with emphasis on some unusual cytological features. ( 28905497 )
2017
27
Frequent expression of human leukocyte antigen class I and the status of intratumoral immune cells in alveolar soft part sarcoma. ( 28454377 )
2017
28
Long-term results of therapy with sunitinib in metastatic alveolar soft part sarcoma. ( 28291905 )
2017
29
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005). ( 29286582 )
2017
30
Alveolar soft part sarcoma of orbit: A rare diagnosis. ( 28844593 )
2017
31
Alveolar soft part sarcoma of the orbit, a case report of a rare tumor. ( 29022959 )
2017
32
Alveolar Soft Part Sarcoma with Unusual Cardiac Metastasis: A Case Report and Review of the Literature. ( 28845314 )
2017
33
Alveolar soft part sarcoma presenting with back pain. ( 28446481 )
2017
34
Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years. ( 29214088 )
2017
35
Alveolar soft part sarcoma metastatic to the mandible: A report and review of literature. ( 28774857 )
2017
36
The Significant Effects of Pazopanib on Multiple Pulmonary Metastatic Lesions of Alveolar Soft Part Sarcoma: A Case Report. ( 28060129 )
2017
37
An atypical presentation of alveolar soft part sarcoma of tongue. ( 28706396 )
2017
38
Magnetic Resonance Features and Characteristic Vascular Pattern of Alveolar Soft-Part Sarcoma. ( 28950275 )
2017
39
Identification of target genes of cediranib in alveolar soft part sarcoma using a gene microarray. ( 28454442 )
2017
40
First reported case of alveolar soft part sarcoma in constitutional mismatch repair deficiency syndrome tumor spectrum - diagnosed in one of the siblings with constitutional mismatch repair deficiency. ( 28413802 )
2017
41
Alveolar soft part sarcoma of flexure tendon. ( 29302306 )
2017
42
Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3. European Organization for Research and Treatment of Cancer (EORTC) phase 2 trial 90101 "CREATE". ( 29216400 )
2017
43
Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics. ( 28009610 )
2016
44
A retrospective analysis of 14 consecutive Chinese patients with unresectable or metastatic alveolar soft part sarcoma treated with sunitinib. ( 27604635 )
2016
45
Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. ( 26990748 )
2016
46
Primary alveolar soft part sarcoma of the right femur and primary lymphoma of the left femur: A case report and literature review. ( 26870173 )
2016
47
Treatment of Metastatic, Refractory Alveolar Soft Part Sarcoma: Case Reports and Literature Review of Treatment Options in the Era of Targeted Therapy. ( 27164526 )
2016
48
Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung-a morphologic pitfall on cytology and aberrant CD10 expression on histology. ( 26693959 )
2016
49
Alveolar soft-part sarcoma in the left forearm with cardiac metastasis: A case report and literature review. ( 26870171 )
2016
50
Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metastasis. ( 27979841 )
2016

Variations for Alveolar Soft Part Sarcoma

Cosmic variations for Alveolar Soft Part Sarcoma:

9
(show all 32)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44190 TP53 soft tissue,liver,sarcoma,NS c.359A>T p.K120M 17:7676010-7676010 22
2 COSM10667 TP53 soft tissue,liver,sarcoma,NS c.646G>A p.V216M 17:7674885-7674885 22
3 COSM6979022 SRC soft tissue,lung,sarcoma,NS c.205T>G p.S69A 20:37384358-37384358 22
4 COSM389868 RAC1 soft tissue,lung,sarcoma,NS c.476C>T p.A159V 7:6402343-6402343 22
5 COSM6979014 PTPRD soft tissue,lung,sarcoma,NS c.4160C>T p.A1387V 9:8404587-8404587 22
6 COSM6959031 PTCH1 soft tissue,lung,sarcoma,NS c.2921T>G p.F974C 9:95458260-95458260 22
7 COSM6979006 PBRM1 soft tissue,lung,sarcoma,NS c.2834G>A p.R945H 3:52589201-52589201 22
8 COSM6979021 PAK5 soft tissue,lung,sarcoma,NS c.41C>A p.P14Q 20:9644288-9644288 22
9 COSM520 KRAS soft tissue,lung,sarcoma,NS c.35G>T p.G12V 12:25245350-25245350 22
10 COSM516 KRAS soft tissue,lung,sarcoma,NS c.34G>T p.G12C 12:25245351-25245351 22
11 COSM487 HRAS soft tissue,neck,sarcoma,NS c.37G>A p.G13S 11:534286-534286 22
12 COSM6979011 HGF soft tissue,lung,sarcoma,NS c.1711G>T p.V571L 7:81706333-81706333 22
13 COSM1732355 H3F3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 22
14 COSM6959034 GPS2 soft tissue,lung,sarcoma,NS c.454C>T p.Q152* 17:7313932-7313932 22
15 COSM3908208 GNAQ soft tissue,bone,sarcoma,NS c.442C>T p.R148* 9:77815650-77815650 22
16 COSM6979008 FOXP1 soft tissue,lung,sarcoma,NS c.74A>G p.H25R 3:71198308-71198308 22
17 COSM3908209 soft tissue,bone,sarcoma,NS c.355C>T p.R119* 9:77815650-77815650 22
18 COSM6959030 soft tissue,lung,sarcoma,NS c.2921T>G p.F974C 9:95458260-95458260 22
19 COSM6979007 soft tissue,lung,sarcoma,NS c.2834G>A p.R945H 3:52589201-52589201 22
20 COSM6979005 soft tissue,lung,sarcoma,NS c.2738G>A p.R913H 3:52589201-52589201 22
21 COSM6979012 soft tissue,lung,sarcoma,NS c.4160C>T p.A1387V 9:8404587-8404587 22
22 COSM6979020 soft tissue,lung,sarcoma,NS c.1831+1G>T p.? 19:45353082-45353082 22
23 COSM1140136 soft tissue,lung,sarcoma,NS c.34G>T p.G12C 12:25245351-25245351 22
24 COSM6979017 soft tissue,lung,sarcoma,NS c.2573C>T p.A858V 9:8404587-8404587 22
25 COSM6979010 soft tissue,lung,sarcoma,NS c.1036G>T p.V346L 3:179203766-179203766 22
26 COSM6979009 soft tissue,lung,sarcoma,NS c.74A>G p.H25R 3:71198308-71198308 22
27 COSM1154840 soft tissue,lung,sarcoma,NS c.533C>T p.A178V 7:6402343-6402343 22
28 COSM6959033 soft tissue,lung,sarcoma,NS c.2918T>G p.F973C 9:95458260-95458260 22
29 COSM6979016 soft tissue,lung,sarcoma,NS c.2930C>T p.A977V 9:8404587-8404587 22
30 COSM6979013 soft tissue,lung,sarcoma,NS c.2942C>T p.A981V 9:8404587-8404587 22
31 COSM6959032 soft tissue,lung,sarcoma,NS c.2918T>G p.F973C 9:95458260-95458260 22
32 COSM6979015 soft tissue,lung,sarcoma,NS c.2939C>T p.A980V 9:8404587-8404587 22

Expression for Alveolar Soft Part Sarcoma

Search GEO for disease gene expression data for Alveolar Soft Part Sarcoma.

Pathways for Alveolar Soft Part Sarcoma

Pathways related to Alveolar Soft Part Sarcoma according to KEGG:

37
# Name Kegg Source Accession
1 Transcriptional misregulation in cancer hsa05202

Pathways related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 MET TCF3 VIM
2 11.22 MYOD1 TCF3 TFE3
3 11.19 ASPSCR1 MET TCF3 TFE3
4
Show member pathways
10.9 MYF6 MYOD1 TCF3

GO Terms for Alveolar Soft Part Sarcoma

Biological processes related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of myoblast differentiation GO:0045663 9.37 MYF6 MYOD1
2 positive regulation of myoblast fusion GO:1901741 9.32 MYF6 MYOD1
3 intermediate filament organization GO:0045109 9.26 DES VIM
4 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYF6 MYOD1
5 muscle cell fate commitment GO:0042693 8.96 MYF6 MYOD1
6 positive regulation of muscle cell differentiation GO:0051149 8.8 MYF6 MYOD1 TCF3

Molecular functions related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.46 MYF6 MYOD1 TCF3 TFE3
2 laminin binding GO:0043236 9.26 ADAM9 ECM1
3 protein dimerization activity GO:0046983 9.26 MYF6 MYOD1 TCF3 TFE3
4 E-box binding GO:0070888 8.8 MYF6 MYOD1 TCF3

Sources for Alveolar Soft Part Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....