ASPS
MCID: ALV005
MIFTS: 55

Alveolar Soft Part Sarcoma (ASPS)

Categories: Cancer diseases, Genetic diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Alveolar Soft Part Sarcoma

MalaCards integrated aliases for Alveolar Soft Part Sarcoma:

Name: Alveolar Soft Part Sarcoma 58 12 77 54 60 38 30 15 17 74
Asps 58 54 60
Sarcoma, Alveolar Soft Part 45 41
Alveolar Soft-Part Sarcoma 58 13
Childhood Alveolar Soft Part Sarcoma 12
Pediatric Alveolar Soft Part Sarcoma 12
Childhood Alveolar Soft-Part Sarcoma 74
Adult Alveolar Soft Part Sarcoma 12
Adult Alveolar Soft-Part Sarcoma 74
Alveolar Soft Tissue Sarcoma 60
Sarcoma Alveolar Soft Part 56

Characteristics:

Orphanet epidemiological data:

60
alveolar soft tissue sarcoma
Age of onset: All ages;

HPO:

33
alveolar soft part sarcoma:
Inheritance somatic mutation


Classifications:



External Ids:

Disease Ontology 12 DOID:4239
OMIM 58 606243
KEGG 38 H00051
MeSH 45 D018234
SNOMED-CT 69 88195001
MESH via Orphanet 46 D018234
ICD10 via Orphanet 35 C49.9
UMLS via Orphanet 75 C0206657
Orphanet 60 ORPHA163699
MedGen 43 C0206657
SNOMED-CT via HPO 70 124975008 404056007

Summaries for Alveolar Soft Part Sarcoma

NIH Rare Diseases : 54 Alveolar soft part sarcoma (ASPS) is a rare, slow-growing soft tissue sarcoma. Although it has been described in a variety of locations, it most commonly develops on the lower extremities in adults and in the head and neck region of children. ASPS generally presents as a soft, pain-less lump that is often not associated with any additional signs and symptoms. In many cases, the condition is not diagnosed until the affected person develops symptoms of metastasis to other sites such as the lungs, bones, central nervous system and/or liver. The underlying cause of ASPS is poorly understood. Most cases occur sporadically in people with no family history of the condition. ASPS is generally treated with surgery; radiation therapy and/or chemotherapy may be considered if the tumor returns.

MalaCards based summary : Alveolar Soft Part Sarcoma, also known as asps, is related to spindle cell sarcoma and granular cell tumor. An important gene associated with Alveolar Soft Part Sarcoma is ASPSCR1 (ASPSCR1 Tether For SLC2A4, UBX Domain Containing), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are alveolar soft part sarcoma and homeostasis/metabolism

Disease Ontology : 12 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

OMIM : 58 Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clinical behavior (Lieberman et al., 1989; Ordonez, 1999). The typical histology of ASPS shows well-defined nests of cells with abundant pink cytoplasm. The loss of central cohesion produces a pseudoalveolar appearance (Ladanyi et al., 2001). (606243)

Wikipedia : 77 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft-tissue sarcoma, that grows... more...

Related Diseases for Alveolar Soft Part Sarcoma

Diseases related to Alveolar Soft Part Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.8 DES VIM
2 granular cell tumor 30.6 DES ENO2 VIM
3 chordoma 30.4 DES MET VIM
4 perivascular epithelioid cell tumor 30.3 DES SYP VIM
5 rhabdomyosarcoma 29.0 DES ENO2 MB MET MYF6 MYOD1
6 cervical alveolar soft part sarcoma 12.8
7 vulvar alveolar soft part sarcoma 12.8
8 sarcoma 11.4
9 renal cell carcinoma, xp11-associated 10.5 ASPSCR1 TFE3
10 myofibroma 10.4 DES MB
11 giant cell myocarditis 10.4 DES MB
12 infantile digital fibromatosis 10.4 DES VIM
13 lymphangiomatosis 10.4 DES VIM
14 angiolipoma 10.4 DES VIM
15 spindle cell lipoma 10.4 DES VIM
16 parachordoma 10.4 DES VIM
17 syringocystadenoma papilliferum 10.4 DES VIM
18 gallbladder sarcoma 10.4 DES MYOD1
19 bilateral retinoblastoma 10.4 DES MB
20 benign metastasizing leiomyoma 10.4 DES VIM
21 breast rhabdomyosarcoma 10.4 MB MYOD1
22 biphasic synovial sarcoma 10.4 DES VIM
23 vagina sarcoma 10.4
24 malignant fibrous histiocytoma of bone 10.4 DES MYOD1
25 syringoma 10.4 DES VIM
26 cystic nephroma 10.4 DES VIM
27 horner's syndrome 10.4 DES MYOD1
28 malignant ectomesenchymoma 10.4 DES ENO2
29 ectomesenchymoma 10.4 DES ENO2
30 juvenile xanthogranuloma 10.4 DES VIM
31 pleomorphic rhabdomyosarcoma 10.4 MB MYOD1
32 pleomorphic liposarcoma 10.4 DES VIM
33 bednar tumor 10.4 ENO2 VIM
34 kidney rhabdoid cancer 10.4 ENO2 MB
35 adult fibrosarcoma 10.4 MB MYOD1
36 cutaneous fibrous histiocytoma 10.4 DES VIM
37 ependymoblastoma 10.4 MET VIM
38 doxorubicin induced cardiomyopathy 10.4 DES MET
39 congenital fibrosarcoma 10.3 DES VIM
40 acral lentiginous melanoma 10.3 MET VIM
41 sertoli cell tumor 10.3 SYP VIM
42 reticulum cell sarcoma 10.3 DES VIM
43 primary hepatic neuroendocrine carcinoma 10.3 SYP VIM
44 adenosarcoma 10.3 DES MB
45 chordoid meningioma 10.3 SYP VIM
46 mesenchymal chondrosarcoma 10.3 DES VIM
47 renal cell carcinoma, nonpapillary 10.3
48 carotid body cancer 10.3 ENO2 SYP
49 gas gangrene 10.3 MB MYOD1
50 malignant sertoli cell tumor 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Alveolar Soft Part Sarcoma:



Diseases related to Alveolar Soft Part Sarcoma

Symptoms & Phenotypes for Alveolar Soft Part Sarcoma

Human phenotypes related to Alveolar Soft Part Sarcoma:

33
# Description HPO Frequency HPO Source Accession
1 alveolar soft part sarcoma 33 HP:0012218

Clinical features from OMIM:

606243

MGI Mouse Phenotypes related to Alveolar Soft Part Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ADAM9 DES MB MET MLH1 MYF6
2 mortality/aging MP:0010768 10.06 ADAM9 DES MB MET MLH1 MYF6
3 muscle MP:0005369 9.73 DES MB MET MYF6 MYOD1 VIM
4 neoplasm MP:0002006 9.63 ADAM9 MET MLH1 MYF6 MYOD1 TCF3
5 normal MP:0002873 9.5 ADAM9 MET MYF6 MYOD1 SYP TCF3
6 respiratory system MP:0005388 9.17 ENO2 MB MET MLH1 MYF6 MYOD1

Drugs & Therapeutics for Alveolar Soft Part Sarcoma

Drugs for Alveolar Soft Part Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
5
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 3 50-18-0, 6055-19-2 2907
7
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
11
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
12
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
13
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
14
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
15
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
16
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
17 Alkylating Agents Phase 3,Phase 2,Phase 1
18 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
19 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
20 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
23 Immunologic Factors Phase 3,Phase 1,Phase 2
24 Histamine Antagonists Phase 3
25 Neurotransmitter Agents Phase 3,Phase 1
26 Gastrointestinal Agents Phase 3,Phase 2
27 Serotonin Agents Phase 3
28 Serotonin Antagonists Phase 3
29 Anti-Allergic Agents Phase 3
30 Antipruritics Phase 3
31 Dermatologic Agents Phase 3
32 Histamine H1 Antagonists Phase 3
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
35 Etoposide phosphate Phase 3,Phase 2
36 Antirheumatic Agents Phase 3,Phase 2
37 Antimitotic Agents Phase 3,Phase 2
38 Anti-Infective Agents Phase 3,Phase 2
39 Immunosuppressive Agents Phase 3,Phase 2
40 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
41
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
42
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
43
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
44
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
45
Pembrolizumab Approved Phase 2 1374853-91-4
46
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
47
Loperamide Approved Phase 2 53179-11-6 3955
48
Allopurinol Approved Phase 2 315-30-0 2094
49
Mecasermin Approved, Investigational Phase 2 68562-41-4
50
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 A Phase III Trial of Anlotinib in Metastatic or Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma and Synovial Sarcoma Recruiting NCT03016819 Phase 3 AL 3818;Dacarbazine
3 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
5 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
6 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
7 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
8 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Completed NCT00423618 Phase 3
9 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
10 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
11 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
13 Autologous Dendritic Cell Vaccine Loaded With Allogeneic Tumor Lysate Expression of Cancer Testis Antigens in Patients With Soft Tissue Sarcoma Unknown status NCT01883518 Phase 1, Phase 2
14 Pazopanib for Metastatic Alveolar Soft Part Sarcoma Terminated NCT02113826 Phase 2 Pazopanib
15 Clinical Trial in Chinese Patients of Elapsed/Metastatic/Unresectable Alveolar Soft Part Sarcoma(GB226) Recruiting NCT03623581 Phase 2
16 Atezolizumab in Treating Patients With Newly Diagnosed and Metastatic Alveolar Soft Part Sarcoma That Cannot Be Removed by Surgery Recruiting NCT03141684 Phase 2 Atezolizumab
17 A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS) Active, not recruiting NCT01337401 Phase 2 Cediranib;Placebo
18 Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas Active, not recruiting NCT02636725 Phase 2 Axitinib;Pembrolizumab
19 Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma Active, not recruiting NCT00942877 Phase 2 AZD2171
20 Sunitinib or Cediranib for Alveolar Soft Part Sarcoma Recruiting NCT01391962 Phase 2 Cediranib;Sunitinib
21 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
22 Phase 2 Study in Patients With MiT Tumors Completed NCT00557609 Phase 2 ARQ 197
23 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
24 CREATE: Cross-tumoral Phase 2 With Crizotinib Active, not recruiting NCT01524926 Phase 2 Crizotinib (PF-02341066)
25 Treatment of Patients With RAD001 With Progressive Sarcoma Completed NCT00767819 Phase 2 Everolimus
26 Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors Recruiting NCT02867592 Phase 2 Cabozantinib;Cabozantinib S-malate
27 Trial of Dasatinib in Advanced Sarcomas Completed NCT00464620 Phase 2 Dasatinib
28 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
29 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
30 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
31 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
32 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
33 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
34 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
35 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
36 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
37 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
38 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
39 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
40 Vaccine Trial for Clear Cell Sarcoma, Pediatric Renal Cell Carcinoma, Alveolar Soft Part Sarcoma and Children With Stage IV Melanoma Active, not recruiting NCT00258687 Phase 1
41 Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma Not yet recruiting NCT03880123 Phase 1 Selinexor;Ixazomib
42 A Study of FAZ053 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies. Active, not recruiting NCT02936102 Phase 1 FAZ053;PDR001
43 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
44 Collection of Alveolar Soft Part Sarcoma and Blood Specimens for Research Completed NCT00340353
45 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
46 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Alveolar Soft Part Sarcoma

Cochrane evidence based reviews: sarcoma, alveolar soft part

Genetic Tests for Alveolar Soft Part Sarcoma

Genetic tests related to Alveolar Soft Part Sarcoma:

# Genetic test Affiliating Genes
1 Alveolar Soft Part Sarcoma 30 ASPSCR1

Anatomical Context for Alveolar Soft Part Sarcoma

MalaCards organs/tissues related to Alveolar Soft Part Sarcoma:

42
Bone, Lung, Liver, Tongue, Breast, Cervix, Kidney

Publications for Alveolar Soft Part Sarcoma

Articles related to Alveolar Soft Part Sarcoma:

(show top 50) (show all 565)
# Title Authors Year
1
Alveolar Soft-Part Sarcoma of the Tongue. ( 30235167 )
2019
2
A Phase II Trial of Pazopanib in Patients with Metastatic Alveolar Soft Part Sarcoma. ( 30254189 )
2019
3
Fine-needle aspiration of alveolar soft part sarcoma: Histologic correlation and aberrant CD68 expression. ( 30457206 )
2019
4
Brain Metastases and Place of Antiangiogenic Therapies in Alveolar Soft Part Sarcoma: A Retrospective Analysis of the French Sarcoma Group. ( 30626710 )
2019
5
Lingual Alveolar Soft Part Sarcoma in a 1-Year-Old Infant: Youngest Reported Case With Characteristic ASPSCR1-TFE3 Fusion. ( 30744536 )
2019
6
Alveolar soft part sarcoma metastatic to the breast: a case report. ( 30832622 )
2019
7
Second Reported Case of Pediatric Bladder Alveolar Soft Part Sarcoma as Secondary Malignancy After Prior Cytotoxic Chemotherapy. ( 30986487 )
2019
8
Axitinib plus pembrolizumab in patients with advanced sarcomas including alveolar soft-part sarcoma: a single-centre, single-arm, phase 2 trial. ( 31078463 )
2019
9
Personalised management of alveolar soft part sarcoma: a promising phase 2 study. ( 31078464 )
2019
10
Blockade of VEGFR and PD-L1 Inhibits Alveolar Soft-Part Sarcoma. ( 31101632 )
2019
11
Alveolar soft part sarcoma: the new primary intracranial malignancy : A case report and review of the literature. ( 28744773 )
2019
12
Correction: Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection. ( 31083679 )
2019
13
Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection. ( 30995262 )
2019
14
Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. ( 30805182 )
2019
15
Malignant perivascular epithelioid cell tumor of the oropharynx with strong TFE3 expression mimicking alveolar soft part sarcoma: a case report and review of the literature. ( 29208563 )
2018
16
Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3: European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'. ( 29216400 )
2018
17
Orbital alveolar soft part sarcoma: A report of 8 cases and review of the literature. ( 29285193 )
2018
18
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005). ( 29286582 )
2018
19
Alveolar soft part sarcoma in children and young adults: A report of 69 cases. ( 29350467 )
2018
20
Alveolar Soft Part Sarcoma Presenting as Hypervascular Adrenal Metastasis. ( 29398970 )
2018
21
Alveolar soft part sarcoma: Clinical presentation, treatment, and outcome in a series of 13 patients. ( 29625801 )
2018
22
Fine needle aspiration of alveolar soft part sarcoma in a child: Cytomorphological clues for the surgical pathologist. ( 29661735 )
2018
23
Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy. ( 29710505 )
2018
24
Pseudoprogression of CNS metastatic disease of alveolar soft part sarcoma during anti-PDL1 treatment. ( 29991973 )
2018
25
Response to Immune Checkpoint Inhibition in Two Patients with Alveolar Soft-Part Sarcoma. ( 30018044 )
2018
26
Alveolar soft-part sarcoma: Primary metastatic disease and metastatic relapse occurring during long-term follow-up: Treatment results of four Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry. ( 30124238 )
2018
27
Positive Tumor Response to Combined Checkpoint Inhibitors in a Patient With Refractory Alveolar Soft Part Sarcoma: A Case Report. ( 30241159 )
2018
28
Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma: A Review. ( 30347044 )
2018
29
Alveolar soft-part sarcoma: can MRI help discriminating from other soft-tissue tumors? A study of the French sarcoma group. ( 30560359 )
2018
30
Effective treatment of advanced alveolar soft part sarcoma with sunitinib: A case report. ( 30572461 )
2018
31
Alveolar soft-part sarcoma of the oral cavity: A review of literature. ( 30574289 )
2018
32
Pediatric Primary Alveolar Soft Part Sarcoma of the Bladder. ( 30687558 )
2018
33
Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature. ( 30895098 )
2018
34
Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. ( 28754721 )
2018
35
Exploring the Histogenesis and Diagnostic Strategy Using Immunoassay and RT-PCR in Alveolar Soft Part Sarcoma. ( 28766250 )
2018
36
Alveolar soft part sarcoma: A case report with emphasis on some unusual cytological features. ( 28905497 )
2018
37
Magnetic Resonance Features and Characteristic Vascular Pattern of Alveolar Soft-Part Sarcoma. ( 28950275 )
2017
38
Alveolar soft part sarcoma of the orbit, a case report of a rare tumor. ( 29022959 )
2017
39
Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. ( 29095301 )
2017
40
Brain metastatic alveolar soft-part sarcoma: Clinicopathological profiles, management and outcomes. ( 29113207 )
2017
41
Alveolar soft part sarcoma occurring in the penis of a 3-year-old boy: A rare case report. ( 29137020 )
2017
42
Alveolar soft part sarcoma with multiple brain and lung metastases in pregnancy: A case report and literature review. ( 29145339 )
2017
43
Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years. ( 29214088 )
2017
44
Alveolar soft part sarcoma of flexure tendon. ( 29302306 )
2017
45
Alveolar soft part sarcoma of the forearm. ( 29618868 )
2017
46
Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. ( 26990748 )
2017
47
Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. ( 27696380 )
2017
48
Perineal alveolar soft part sarcoma treated by laparoscopy-assisted total pelvic exenteration combined with pubic resection. ( 27860404 )
2017
49
Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metastasis. ( 27979841 )
2017
50
Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics. ( 28009610 )
2017

Variations for Alveolar Soft Part Sarcoma

Cosmic variations for Alveolar Soft Part Sarcoma:

9 (show all 32)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44190 TP53 soft tissue,liver,sarcoma,NS c.359A>T p.K120M 17:7676010-7676010 0
2 COSM10667 TP53 soft tissue,liver,sarcoma,NS c.646G>A p.V216M 17:7674885-7674885 0
3 COSM6979022 SRC soft tissue,lung,sarcoma,NS c.205T>G p.S69A 20:37384358-37384358 0
4 COSM389868 RAC1 soft tissue,lung,sarcoma,NS c.476C>T p.A159V 7:6402343-6402343 0
5 COSM6979014 PTPRD soft tissue,lung,sarcoma,NS c.4160C>T p.A1387V 9:8404587-8404587 0
6 COSM6959031 PTCH1 soft tissue,lung,sarcoma,NS c.2921T>G p.F974C 9:95458260-95458260 0
7 COSM6979006 PBRM1 soft tissue,lung,sarcoma,NS c.2834G>A p.R945H 3:52589201-52589201 0
8 COSM6979021 PAK5 soft tissue,lung,sarcoma,NS c.41C>A p.P14Q 20:9644288-9644288 0
9 COSM520 KRAS soft tissue,lung,sarcoma,NS c.35G>T p.G12V 12:25245350-25245350 0
10 COSM516 KRAS soft tissue,lung,sarcoma,NS c.34G>T p.G12C 12:25245351-25245351 0
11 COSM487 HRAS soft tissue,neck,sarcoma,NS c.37G>A p.G13S 11:534286-534286 0
12 COSM6979011 HGF soft tissue,lung,sarcoma,NS c.1711G>T p.V571L 7:81706333-81706333 0
13 COSM1732355 H3F3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 0
14 COSM6959034 GPS2 soft tissue,lung,sarcoma,NS c.454C>T p.Q152* 17:7313932-7313932 0
15 COSM3908208 GNAQ soft tissue,bone,sarcoma,NS c.442C>T p.R148* 9:77815650-77815650 0
16 COSM6979008 FOXP1 soft tissue,lung,sarcoma,NS c.74A>G p.H25R 3:71198308-71198308 0
17 COSM3908209 soft tissue,bone,sarcoma,NS c.355C>T p.R119* 9:77815650-77815650 0
18 COSM6959030 soft tissue,lung,sarcoma,NS c.2921T>G p.F974C 9:95458260-95458260 0
19 COSM6979007 soft tissue,lung,sarcoma,NS c.2834G>A p.R945H 3:52589201-52589201 0
20 COSM6979005 soft tissue,lung,sarcoma,NS c.2738G>A p.R913H 3:52589201-52589201 0
21 COSM6979015 soft tissue,lung,sarcoma,NS c.2939C>T p.A980V 9:8404587-8404587 0
22 COSM6979012 soft tissue,lung,sarcoma,NS c.4160C>T p.A1387V 9:8404587-8404587 0
23 COSM1140136 soft tissue,lung,sarcoma,NS c.34G>T p.G12C 12:25245351-25245351 0
24 COSM6979020 soft tissue,lung,sarcoma,NS c.1831+1G>T p.? 19:45353082-45353082 0
25 COSM6979017 soft tissue,lung,sarcoma,NS c.2573C>T p.A858V 9:8404587-8404587 0
26 COSM6979010 soft tissue,lung,sarcoma,NS c.1036G>T p.V346L 3:179203766-179203766 0
27 COSM6979009 soft tissue,lung,sarcoma,NS c.74A>G p.H25R 3:71198308-71198308 0
28 COSM1154840 soft tissue,lung,sarcoma,NS c.533C>T p.A178V 7:6402343-6402343 0
29 COSM6959033 soft tissue,lung,sarcoma,NS c.2918T>G p.F973C 9:95458260-95458260 0
30 COSM6979016 soft tissue,lung,sarcoma,NS c.2930C>T p.A977V 9:8404587-8404587 0
31 COSM6979013 soft tissue,lung,sarcoma,NS c.2942C>T p.A981V 9:8404587-8404587 0
32 COSM6959032 soft tissue,lung,sarcoma,NS c.2918T>G p.F973C 9:95458260-95458260 0

Expression for Alveolar Soft Part Sarcoma

Search GEO for disease gene expression data for Alveolar Soft Part Sarcoma.

Pathways for Alveolar Soft Part Sarcoma

Pathways related to Alveolar Soft Part Sarcoma according to KEGG:

38
# Name Kegg Source Accession
1 Transcriptional misregulation in cancer hsa05202

Pathways related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 MET TCF3 VIM
2 11.19 ASPSCR1 MET TCF3 TFE3
3 11.02 MYOD1 TCF3 TFE3

GO Terms for Alveolar Soft Part Sarcoma

Biological processes related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of myoblast differentiation GO:0045663 9.37 MYF6 MYOD1
2 intermediate filament organization GO:0045109 9.32 DES VIM
3 positive regulation of myoblast fusion GO:1901741 9.26 MYF6 MYOD1
4 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYF6 MYOD1
5 muscle cell fate commitment GO:0042693 8.96 MYF6 MYOD1
6 positive regulation of muscle cell differentiation GO:0051149 8.8 MYF6 MYOD1 TCF3

Molecular functions related to Alveolar Soft Part Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.46 MYF6 MYOD1 TCF3 TFE3
2 protein dimerization activity GO:0046983 9.26 MYF6 MYOD1 TCF3 TFE3
3 E-box binding GO:0070888 8.8 MYF6 MYOD1 TCF3

Sources for Alveolar Soft Part Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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41 LOVD
43 MedGen
45 MeSH
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47 MGI
50 NCI
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55 NINDS
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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