AD10
MCID: ALZ057
MIFTS: 35

Alzheimer Disease 10 (AD10)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 10

MalaCards integrated aliases for Alzheimer Disease 10:

Name: Alzheimer Disease 10 57 12 70
Alzheimer's Disease 10 12 15
Alzheimer Disease-10 57 13
Ad10 57 12
Alzheimer's Disease 10, Early Onset 12
Alzheimer Disease, Familial, 10 57
Alzheimer Disease Familial 10 12

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
mean age at onset 66.8 years (range 47-77)


HPO:

31
alzheimer disease 10:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0110043
OMIM® 57 609636
ICD10 32 G30
MedGen 41 C1864828
UMLS 70 C1864828

Summaries for Alzheimer Disease 10

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 7q36.

MalaCards based summary : Alzheimer Disease 10, also known as alzheimer's disease 10, is related to alzheimer disease and aphasia, and has symptoms including personality changes An important gene associated with Alzheimer Disease 10 is AD10 (Alzheimer Disease-10), and among its related pathways/superpathways are Alzheimers Disease Pathway and Melatonin metabolism and effects. Affiliated tissues include brain, spinal cord and temporal lobe, and related phenotypes are neurological speech impairment and cerebral cortical atrophy

More information from OMIM: 609636

Related Diseases for Alzheimer Disease 10

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 15
Alzheimer Disease 6 Alzheimer Disease 7
Alzheimer Disease 4 Alzheimer Disease 8
Alzheimer Disease 3 Alzheimer Disease 9
Alzheimer Disease 10 Alzheimer Disease 11
Alzheimer Disease 12 Alzheimer Disease 13
Alzheimer Disease 14 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 10 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 30.8 MAPT APOE AD10 ACHE
2 aphasia 10.0 MAPT APOE
3 subjective cognitive decline 10.0 MAPT APOE
4 posterior cortical atrophy 10.0 MAPT APOE
5 gerstmann syndrome 10.0 MAPT APOE
6 visual agnosia 10.0 MAPT APOE
7 ideomotor apraxia 10.0 MAPT APOE
8 apraxia 10.0 MAPT APOE
9 alexia 10.0 MAPT APOE
10 semantic dementia 10.0 MAPT APOE
11 age-related hearing loss 10.0 MAPT APOE
12 mild cognitive impairment 10.0 MAPT APOE
13 alzheimer disease 7 10.0 MAPT APOE
14 arteriolosclerosis 10.0 MAPT APOE
15 alzheimer disease 2 10.0 MAPT APOE
16 dyscalculia 10.0 MAPT APOE
17 xanthomatosis 10.0 FDX1 APOE
18 brain injury 10.0 MAPT APOE
19 communicating hydrocephalus 10.0 MAPT APOE
20 early-onset, autosomal dominant alzheimer disease 10.0 MAPT APOE
21 ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 9.9 MAPT APOE
22 multiple sclerosis 9.9
23 gastritis 9.9
24 normal pressure hydrocephalus 9.9 MAPT APOE
25 inclusion body myositis 9.8 MAPT APOE
26 simultanagnosia 9.8 MAPT APOE ACHE
27 nominal aphasia 9.8 MAPT APOE ACHE
28 agraphia 9.8 MAPT APOE ACHE
29 binswanger's disease 9.8 MAPT APOE ACHE
30 dementia 9.8 MAPT APOE ACHE
31 rem sleep behavior disorder 9.8 MAPT APOE ACHE
32 amnestic disorder 9.7 MAPT APOE ACHE
33 chromosomal duplication syndrome 9.7 MAPT APOE
34 scrapie 9.7 MAPT APOE ACHE
35 toxic encephalopathy 9.7 MAPT APOE ACHE
36 transient cerebral ischemia 9.7 MAPT ACHE
37 vascular dementia 9.7 MAPT APOE ACHE
38 speech and communication disorders 9.7 MAPT APOE ACHE
39 gerstmann-straussler disease 9.7 YWHAQ MAPT
40 cerebrovascular disease 9.7 MAPT APOE ACHE
41 down syndrome 9.7 MAPT APOE ACHE
42 frontotemporal dementia 9.6 MAPT APOE ACHE
43 sleep disorder 9.6 MAPT APOE
44 nervous system disease 9.6 MAPT APOE ACHE
45 cerebral amyloid angiopathy, cst3-related 9.6 YWHAQ MAPT APOE
46 movement disease 9.6 YWHAQ MAPT APOE
47 creutzfeldt-jakob disease 9.6 YWHAQ MAPT APOE
48 supranuclear palsy, progressive, 1 9.3 YWHAQ MAPT APOE ACHE
49 dementia, lewy body 9.3 YWHAQ MAPT APOE ACHE
50 pick disease of brain 9.3 YWHAQ MAPT APOE ACHE

Graphical network of the top 20 diseases related to Alzheimer Disease 10:



Diseases related to Alzheimer Disease 10

Symptoms & Phenotypes for Alzheimer Disease 10

Human phenotypes related to Alzheimer Disease 10:

31 (show all 6)
# Description HPO Frequency HPO Source Accession
1 neurological speech impairment 31 HP:0002167
2 cerebral cortical atrophy 31 HP:0002120
3 memory impairment 31 HP:0002354
4 dementia 31 HP:0000726
5 personality changes 31 HP:0000751
6 alzheimer disease 31 HP:0002511

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neurologic Central Nervous System:
memory impairment
dementia
speech impairment
praxis
neuroimaging shows cortical atrophy

Neurologic Behavioral Psychiatric Manifestations:
personality changes

Clinical features from OMIM®:

609636 (Updated 20-May-2021)

UMLS symptoms related to Alzheimer Disease 10:


personality changes

MGI Mouse Phenotypes related to Alzheimer Disease 10:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ACHE APOE FDX1 MAPT MFSD2A YWHAQ
2 muscle MP:0005369 9.35 ACHE APOE FDX1 MAPT YWHAQ
3 vision/eye MP:0005391 9.1 ACHE APOE FDX1 MAPT MFSD2A YWHAQ

Drugs & Therapeutics for Alzheimer Disease 10

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 10

Genetic Tests for Alzheimer Disease 10

Anatomical Context for Alzheimer Disease 10

MalaCards organs/tissues related to Alzheimer Disease 10:

40
Brain, Spinal Cord, Temporal Lobe

Publications for Alzheimer Disease 10

Articles related to Alzheimer Disease 10:

(show all 32)
# Title Authors PMID Year
1
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample. 57
16175510 2005
2
Evaluation of the effect of aroma oil as a bath salt on cognitive function. 61
31578055 2020
3
Dementia Diagnoses and Treatment in Geriatric Ward Patients: A Cross-Sectional Study in Poland. 61
33223824 2020
4
FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. 61
29538658 2018
5
Differences in the neural correlates of frontal lobe tests. 61
29372597 2018
6
Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies. 61
29158778 2017
7
Validation of the short version of the 10/66 dementia diagnosis in multiethnic Asian older adults in Singapore. 61
28431511 2017
8
Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease. 61
28614836 2017
9
The MAPT gene is differentially methylated in the progressive supranuclear palsy brain. 61
27709663 2016
10
Why musical memory can be preserved in advanced Alzheimer's disease. 61
26041611 2015
11
Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan. 61
25041813 2014
12
Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: a randomized controlled trial. 61
22982689 2013
13
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. 61
22366796 2012
14
A multicentre RCT on community occupational therapy in Alzheimer's disease: 10 sessions are not better than one consultation. 61
22021760 2011
15
Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy. 61
18971445 2008
16
Current status and future perspectives in telecare for elderly people suffering from chronic diseases. 61
18534954 2008
17
Evaluation of cognitive impairment in older adults: combining brief informant and performance measures. 61
17502471 2007
18
[Phenotypes of oxidation and acetylation in Alzheimer's disease--preliminary report]. 61
17598435 2007
19
ApoE and Alzheimer's disease--10 years later. 61
15520671 2004
20
Explicit and implicit learning in patients with Alzheimer disease and Parkinson disease with dementia. 61
10527111 1999
21
Behavioral and psychiatric manifestations in dementia patients in a community: caregiver burden and outcome. 61
9876961 1998
22
Frontal brain and leptomeningeal biopsy specimens correlated with cerebrospinal fluid outflow resistance and B-wave activity in patients suspected of normal-pressure hydrocephalus. 61
9055288 1997
23
Preferential metabolic involvement of visual cortical areas in a subtype of Alzheimer's disease: clinical implications. 61
8831432 1996
24
Laboratory examinations correlated with severity of dementia. 61
8800434 1996
25
[Epidemiological study of the prognosis and relevant factors of demented patients]. 61
8551690 1995
26
Prevalence and subtypes of dementia in Taiwan: a community survey of 5297 individuals. 61
7836638 1995
27
Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease. 61
8059663 1994
28
A clinicopathologic study of 100 cases of Parkinson's disease. 61
8431132 1993
29
Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects. 61
1636181 1992
30
Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. 61
1436650 1992
31
Dense microspheres in normal human brain. 61
6637399 1983
32
On the distribution of senile changes in the spinal cord. 61
669500 1978

Variations for Alzheimer Disease 10

Expression for Alzheimer Disease 10

Search GEO for disease gene expression data for Alzheimer Disease 10.

Pathways for Alzheimer Disease 10

Pathways related to Alzheimer Disease 10 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 MAPT APOE
2 10.52 APOE ACHE
3 10.07 MFSD2A ACHE

GO Terms for Alzheimer Disease 10

Cellular components related to Alzheimer Disease 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic cleft GO:0043083 8.62 APOE ACHE

Biological processes related to Alzheimer Disease 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.32 FDX1 APOE
2 synapse assembly GO:0007416 9.26 MAPT ACHE
3 phosphatidylcholine biosynthetic process GO:0006656 9.16 MFSD2A ACHE
4 long-chain fatty acid transport GO:0015909 8.96 MFSD2A APOE
5 amyloid precursor protein metabolic process GO:0042982 8.62 APOE ACHE

Molecular functions related to Alzheimer Disease 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 8.96 APOE ACHE
2 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Alzheimer Disease 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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