AD11
MCID: ALZ058
MIFTS: 29

Alzheimer Disease 11 (AD11)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 11

MalaCards integrated aliases for Alzheimer Disease 11:

Name: Alzheimer Disease 11 57 12 70
Alzheimer's Disease 11 12 15
Alzheimer Disease-11 57 13
Ad11 57 12
Alzheimer's Disease 11, Late Onset 12
Alzheimer Disease, Familial, 11 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110044
OMIM® 57 609790
ICD10 32 G30
MedGen 41 C1853360
UMLS 70 C1853360

Summaries for Alzheimer Disease 11

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 9p22.1.

MalaCards based summary : Alzheimer Disease 11, also known as alzheimer's disease 11, is related to alzheimer disease and osteogenic sarcoma. An important gene associated with Alzheimer Disease 11 is AD11 (Alzheimer Disease-11), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). Affiliated tissues include liver and brain.

More information from OMIM: 609790

Related Diseases for Alzheimer Disease 11

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 15
Alzheimer Disease 6 Alzheimer Disease 7
Alzheimer Disease 4 Alzheimer Disease 8
Alzheimer Disease 3 Alzheimer Disease 9
Alzheimer Disease 10 Alzheimer Disease 11
Alzheimer Disease 12 Alzheimer Disease 13
Alzheimer Disease 14 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 10.9
2 osteogenic sarcoma 10.1
3 human immunodeficiency virus type 1 9.9
4 mild cognitive impairment 9.9
5 amnestic disorder 9.9
6 idiopathic edema 9.8 PPARG PPARA
7 alcoholic cardiomyopathy 9.8 PPARG PPARA
8 platelet glycoprotein iv deficiency 9.8 PPARG PPARA
9 maturity-onset diabetes of the young, type 1 9.8 PPARG PPARA
10 adult syndrome 9.8 PPARG PPARA
11 lipodystrophy, familial partial, type 2 9.8 PPARG PPARA
12 proteasome-associated autoinflammatory syndrome 1 9.8 PPARG PPARA
13 tangier disease 9.8 PPARG PPARA
14 abdominal obesity-metabolic syndrome 1 9.8 PPARG PPARA
15 familial hyperlipidemia 9.8 PPARG PPARA
16 lipid storage disease 9.8 PPARG PPARA
17 non-alcoholic steatohepatitis 9.8 PPARG PPARA
18 liposarcoma 9.8 PPARG PPARA
19 inherited metabolic disorder 9.7 PPARG PPARA
20 lipid metabolism disorder 9.7 PPARG PPARA
21 glucose intolerance 9.7 PPARG PPARA
22 fetal akinesia deformation sequence 1 9.7 PPARG PPARA
23 overnutrition 9.7 PPARG PPARA
24 hyperinsulinism 9.7 PPARG PPARA
25 atherosclerosis susceptibility 9.7 PPARG PPARA
26 glucose metabolism disease 9.7 PPARG PPARA
27 lysosomal storage disease 9.7 PPARG PPARA
28 acquired metabolic disease 9.6 PPARG PPARA
29 arteriosclerosis 9.6 PPARG PPARA
30 leptin deficiency or dysfunction 9.5 PPARG PPARA
31 amelogenesis imperfecta, type ig 9.5 SRC PPARG PPARA
32 amelogenesis imperfecta 9.5 SRC PPARG PPARA
33 maturity-onset diabetes of the young 9.5 SRC PPARG PPARA
34 body mass index quantitative trait locus 11 9.4 SRC PPARG PPARA
35 myocardial infarction 9.4 SRC PPARG PPARA
36 fatty liver disease 9.4 PPARG PPARA
37 hypertension, essential 9.3 SRC PPARG PPARA

Graphical network of the top 20 diseases related to Alzheimer Disease 11:



Diseases related to Alzheimer Disease 11

Symptoms & Phenotypes for Alzheimer Disease 11

Clinical features from OMIM®:

609790 (Updated 20-May-2021)

Drugs & Therapeutics for Alzheimer Disease 11

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 11

Genetic Tests for Alzheimer Disease 11

Anatomical Context for Alzheimer Disease 11

MalaCards organs/tissues related to Alzheimer Disease 11:

40
Liver, Brain

Publications for Alzheimer Disease 11

Articles related to Alzheimer Disease 11:

(show all 20)
# Title Authors PMID Year
1
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. 57
18761660 2008
2
Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. 57
14564669 2003
3
Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. 57
12566388 2003
4
Identification of novel genes in late-onset Alzheimer's disease. 57
11113612 2000
5
Biomarkers in Tears and Ocular Surface: A Window for Neurodegenerative Diseases. 61
31658175 2020
6
REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment. 61
31831602 2020
7
Differentiating between Alzheimer's disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging. 61
31397353 2019
8
Quality of end-of-life care in patients with dementia compared to patients with cancer: A population-based register study. 61
30059515 2018
9
Enhancement of Visuospatial Working Memory by the Differential Outcomes Procedure in Mild Cognitive Impairment and Alzheimer's Disease. 61
30524264 2018
10
[Clinical Analysis of Evaluation of the Swallowing Function before Gastrostomy in an Acute-care Hospital for Elderly People]. 61
26964394 2015
11
PET probes for imaging brain acetylcholinesterase. 61
24285323 2013
12
The spectrum of disease in chronic traumatic encephalopathy. 61
23208308 2013
13
[Effectiveness of perforator flaps for elderly patients with ischia-sacral ulcers]. 61
21675114 2011
14
A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI. 61
22163278 2011
15
11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage. 61
20142615 2010
16
EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease. 61
16854500 2007
17
Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. 61
16802294 2006
18
EEG coherence reflects regional corpus callosum area in Alzheimer's disease. 61
15608007 2005
19
[An analysis of the causes of dementia in 383 elderly autopsied cases]. 61
14636468 2003
20
Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease. 61
8296902 1994

Variations for Alzheimer Disease 11

Expression for Alzheimer Disease 11

Search GEO for disease gene expression data for Alzheimer Disease 11.

Pathways for Alzheimer Disease 11

GO Terms for Alzheimer Disease 11

Biological processes related to Alzheimer Disease 11 according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.76 SRC PPARG PPARA
2 positive regulation of transcription, DNA-templated GO:0045893 9.71 SRC PPARG PPARA
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.59 PPARG PPARA
4 rhythmic process GO:0048511 9.58 PPARG PPARA
5 negative regulation of inflammatory response GO:0050728 9.57 PPARG PPARA
6 response to organic cyclic compound GO:0014070 9.56 PPARG PPARA
7 cellular response to insulin stimulus GO:0032869 9.55 SRC PPARG
8 regulation of lipid metabolic process GO:0019216 9.52 PPARG PPARA
9 regulation of circadian rhythm GO:0042752 9.51 PPARG PPARA
10 response to mechanical stimulus GO:0009612 9.49 SRC PPARG
11 hormone-mediated signaling pathway GO:0009755 9.48 PPARG PPARA
12 negative regulation of signaling receptor activity GO:2000272 9.46 PPARG PPARA
13 intracellular receptor signaling pathway GO:0030522 9.43 PPARG PPARA
14 response to lipid GO:0033993 9.4 PPARG PPARA
15 negative regulation of telomerase activity GO:0051974 9.37 SRC PPARG
16 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.32 PPARG PPARA
17 negative regulation of cholesterol storage GO:0010887 9.26 PPARG PPARA
18 positive regulation of fatty acid oxidation GO:0046321 9.16 PPARG PPARA
19 positive regulation of fatty acid metabolic process GO:0045923 8.96 PPARG PPARA
20 negative regulation of sequestering of triglyceride GO:0010891 8.62 PPARG PPARA

Molecular functions related to Alzheimer Disease 11 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 9.16 PPARG PPARA
2 estrogen receptor binding GO:0030331 8.96 SRC PPARG
3 RNA polymerase II repressing transcription factor binding GO:0001103 8.62 PPARG PPARA

Sources for Alzheimer Disease 11

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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