AD12
MCID: ALZ012
MIFTS: 27

Alzheimer Disease 12 (AD12)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 12

MalaCards integrated aliases for Alzheimer Disease 12:

Name: Alzheimer Disease 12 58 12 13 74
Ad12 58 12
Alzheimer Disease, Familial, 12 58
Alzheimer Disease Familial 12 12
Alzheimer's Disease 12 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110045
OMIM 58 611073
ICD10 34 G30
MedGen 43 C1970209
UMLS 74 C1970209

Summaries for Alzheimer Disease 12

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.

MalaCards based summary : Alzheimer Disease 12, also known as ad12, is related to alzheimer disease and alzheimer disease 5. An important gene associated with Alzheimer Disease 12 is AD12 (Alzheimer Disease 12). The drugs Tacrolimus and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and bone.

Description from OMIM: 611073

Related Diseases for Alzheimer Disease 12

Symptoms & Phenotypes for Alzheimer Disease 12

Clinical features from OMIM:

611073

Drugs & Therapeutics for Alzheimer Disease 12

Drugs for Alzheimer Disease 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
2 Immunosuppressive Agents Phase 4
3 Immunologic Factors Phase 4
4 Calcineurin Inhibitors Phase 4
5 Antibodies Phase 4
6 Vaccines Phase 4
7 Immunoglobulins Phase 4
8
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
9 Antimetabolites Phase 1
10 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis Completed NCT01745159 Phase 4 tacrolimus
2 Evaluation of Antibody Persistence Following 4 MenACWY Vaccinations Completed NCT02446691 Phase 4
3 Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers Completed NCT01843725 Phase 1 capecitabine;aflibercept;Capecitabine
4 Understanding Disparities in Healthcare and Primary Care Provider Quality Completed NCT02626910
5 Realizing Opportunities for Self Empowerment Completed NCT02087956 Not Applicable
6 Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes Completed NCT02038959 Not Applicable

Search NIH Clinical Center for Alzheimer Disease 12

Genetic Tests for Alzheimer Disease 12

Anatomical Context for Alzheimer Disease 12

MalaCards organs/tissues related to Alzheimer Disease 12:

42
Testes, Breast, Bone

Publications for Alzheimer Disease 12

Articles related to Alzheimer Disease 12:

(show all 28)
# Title Authors Year
1
Using the AD12-ICT rapid-format test to detect Wuchereria bancrofti circulating antigens in comparison to Og4C3-ELISA and nucleopore membrane filtration and microscopy techniques. ( 22392137 )
2012
2
Intraperitoneal dissemination of Ad12-induced undifferentiated neuroectodermal hamster tumors: de novo methylation and transcription patterns of integrated viral and of cellular genes. ( 14609629 )
2003
3
Overexpression of the adenovirus type 12 (Ad12) pTP or E1A gene facilitates Ad12 DNA replication in nonpermissive BHK21 hamster cells. ( 11581373 )
2001
4
Synthesis and turnover of beta2-microglobulin in Ad12-transformed cells defective in assembly and transport of class I major histocompatibility complex molecules. ( 8995269 )
1997
5
Insufficient levels of NFIII and its low affinity for the origin of adenovirus type 12 (Ad12) DNA replication contribute to the abortive infection of BHK21 hamster cells by Ad12. ( 8892924 )
1996
6
Selective loss of unmethylated segments of integrated Ad12 genomes in revertants of the adenovirus type 12-transformed cell line T637. ( 8578863 )
1995
7
E1A oncogene of adenovirus-12 mediates trans-repression of MHC class I transcription in Ad5/Ad12 somatic hybrid transformed cells. ( 8053163 )
1994
8
The adenovirus e1a-associated p300 protein is differentially phosphorylated in ad12 e1a-compared to ad5 e1a-transformed rat-cells. ( 21559698 )
1994
9
Altered host range phenotype of the transformation-defective Ad12 mutant CS-1 is due to deletions in the E1 region. ( 7928288 )
1994
10
Adenovirus 12-mediated down-regulation of the major histocompatibility complex (MHC) class I promoter: identification of a negative regulatory element responsive to Ad12 E1A. ( 7984430 )
1994
11
Immortalization of mouse bone marrow-derived mast cells with Ad12-SV40 virus. ( 7683224 )
1993
12
Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range. ( 1534849 )
1992
13
Changes in NF-kappa B and ISGF3 DNA binding activities are responsible for differences in MHC and beta-IFN gene expression in Ad5- versus Ad12-transformed cells. ( 1756724 )
1991
14
Arrangement and expression of integrated adenovirus type 12 DNA in the transformed hamster cell line HA12/7: amplification of Ad12 and c-myc DNAs and evidence for hybrid viral-cellular transcripts. ( 2773593 )
1989
15
Cellular protein differences between nontumorigenic Ad5 and tumorigenic Ad12 transformed mouse cells. ( 3727404 )
1986
16
Structure of viral DNA in a rat cell line, GY1, transformed by Ad12 HindIII fragment-G. ( 3002026 )
1986
17
Transforming properties of a 15-kDa truncated Ad12 E1A gene product. ( 3014724 )
1986
18
How reliable is amino acid sequence homology in predicting similarity of structure and function of c-myc and Ad12 E1A oncogenic proteins? ( 3091845 )
1986
19
Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. ( 2579430 )
1985
20
Structure and function of adenovirus DNA binding protein: comparison of the amino acid sequences of the Ad5 and Ad12 proteins derived from the nucleotide sequence of the corresponding genes. ( 6308889 )
1983
21
Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. ( 6312680 )
1983
22
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a. ( 11894912 )
1983
23
Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids. ( 7101731 )
1982
24
Effector cells working for rejection of Ad12 tumors in mice. ( 6302452 )
1982
25
The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets. ( 7326748 )
1981
26
Close association of virus-specific cell surface and H-2 antigens in Ad12-infected and -transformed mouse cells. ( 7231218 )
1981
27
Structure and gene organization in the transformed Hind III-G fragment of Ad12. ( 6251973 )
1980
28
Susceptibility of Ad12-transformed S (+) and S (-) mouse cells to cell-mediated immunity in vitro. ( 530102 )
1979

Variations for Alzheimer Disease 12

Expression for Alzheimer Disease 12

Search GEO for disease gene expression data for Alzheimer Disease 12.

Pathways for Alzheimer Disease 12

GO Terms for Alzheimer Disease 12

Sources for Alzheimer Disease 12

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75 UMLS via Orphanet
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