Alzheimer Disease 12 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Alzheimer Disease 12

MalaCards integrated aliases for Alzheimer Disease 12:

Name: Alzheimer Disease 12 ⁵⁷ ¹² ¹³ ⁷³

Ad12 ⁵⁷ ¹²

Alzheimer Disease, Familial, 12 ⁵⁷

Alzheimer Disease Familial 12 ¹²

Alzheimer's Disease 12 ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the nervous system

Other degenerative diseases of the nervous system

Alzheimer disease

External Ids:

OMIM ⁵⁷ 611073

Disease Ontology ¹² DOID:0110045

ICD10 ³³ G30

MedGen ⁴² C1970209

UMLS ⁷³ C1970209

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Summaries for Alzheimer Disease 12

Disease Ontology : ¹² An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.

MalaCards based summary : Alzheimer Disease 12, also known as ad12, is related to alzheimer disease. An important gene associated with Alzheimer Disease 12 is AD12 (Alzheimer Disease 12). The drugs Tacrolimus and Calcineurin Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include testes and breast.

Description from OMIM: 611073

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Related Diseases for Alzheimer Disease 12

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2	Alzheimer Disease 16
Alzheimer Disease 5	Alzheimer Disease 6
Alzheimer Disease 7	Alzheimer Disease 4
Alzheimer Disease 8	Alzheimer Disease 3
Alzheimer Disease 9	Alzheimer Disease 10
Alzheimer Disease 11	Alzheimer Disease 12
Alzheimer Disease 13	Alzheimer Disease 14
Alzheimer Disease 15	Alzheimer Disease 17
Alzheimer Disease 18	Alzheimer Disease 19
Early-Onset Familial Alzheimer Disease	Alzheimer Disease Type 1
Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 12 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	alzheimer disease	11.1

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Symptoms & Phenotypes for Alzheimer Disease 12

Clinical features from OMIM:

611073

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Drugs & Therapeutics for Alzheimer Disease 12

Drugs for Alzheimer Disease 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

2

Calcineurin Inhibitors

Phase 4

3

Immunosuppressive Agents

Phase 4

4

Capecitabine

Approved, Investigational

Phase 1

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

CAPECITABINE

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

5

Antimetabolites

Phase 1

6

Antimetabolites, Antineoplastic

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis	Completed	NCT01745159	Phase 4	tacrolimus
2	Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers	Completed	NCT01843725	Phase 1	capecitabine;aflibercept;Capecitabine
3	Understanding Disparities in Healthcare and Primary Care Provider Quality	Completed	NCT02626910
4	Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes	Completed	NCT02038959	Not Applicable
5	Realizing Opportunities for Self Empowerment	Active, not recruiting	NCT02087956	Not Applicable

Search NIH Clinical Center for Alzheimer Disease 12

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Genetic Tests for Alzheimer Disease 12

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Anatomical Context for Alzheimer Disease 12

MalaCards organs/tissues related to Alzheimer Disease 12:

⁴¹

Testes, Breast

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Publications for Alzheimer Disease 12

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Genes for Alzheimer Disease 12

Genes related to Alzheimer Disease 12 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AD12	Alzheimer Disease 12	Genetic Locus	58.31	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)

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Variations for Alzheimer Disease 12

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Expression for Alzheimer Disease 12

Search GEO for disease gene expression data for Alzheimer Disease 12.

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Pathways for Alzheimer Disease 12

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GO Terms for Alzheimer Disease 12

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Sources for Alzheimer Disease 12

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia