Alzheimer Disease 12 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALZ012 MIFTS: 27	Alzheimer Disease 12 Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Alzheimer Disease 12

MalaCards integrated aliases for Alzheimer Disease 12:

Name: Alzheimer Disease 12 ⁵⁸ ¹² ¹³ ⁷⁴

Ad12 ⁵⁸ ¹²

Alzheimer Disease, Familial, 12 ⁵⁸

Alzheimer Disease Familial 12 ¹²

Alzheimer's Disease 12 ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the nervous system

Other degenerative diseases of the nervous system

Alzheimer disease

External Ids:

Disease Ontology ¹² DOID:0110045

OMIM ⁵⁸ 611073

ICD10 ³⁴ G30

MedGen ⁴³ C1970209

UMLS ⁷⁴ C1970209

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Summaries for Alzheimer Disease 12

Disease Ontology : ¹² An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.

MalaCards based summary : Alzheimer Disease 12, also known as ad12, is related to alzheimer disease and alzheimer disease 5. An important gene associated with Alzheimer Disease 12 is AD12 (Alzheimer Disease 12). The drugs Tacrolimus and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and bone.

Description from OMIM: 611073

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Related Diseases for Alzheimer Disease 12

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2	Alzheimer Disease 16
Alzheimer Disease 5	Alzheimer Disease 6
Alzheimer Disease 7	Alzheimer Disease 4
Alzheimer Disease 8	Alzheimer Disease 3
Alzheimer Disease 9	Alzheimer Disease 10
Alzheimer Disease 11	Alzheimer Disease 12
Alzheimer Disease 13	Alzheimer Disease 14
Alzheimer Disease 15	Alzheimer Disease 17
Alzheimer Disease 18	Alzheimer Disease 19
Alzheimer's Disease 1	Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 12 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	alzheimer disease	11.3
2	alzheimer disease 5	10.5

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Symptoms & Phenotypes for Alzheimer Disease 12

Clinical features from OMIM:

611073

Sources

Drugs & Therapeutics for Alzheimer Disease 12

Drugs for Alzheimer Disease 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

6473866 445643 439492

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

Immunosuppressive Agents

Phase 4

Immunologic Factors

Phase 4

Calcineurin Inhibitors

Phase 4

Vaccines

Phase 4

Immunoglobulins

Phase 4

Antibodies

Phase 4

Capecitabine

Approved, Investigational

Phase 1

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

Antimetabolites

Phase 1

Antimetabolites, Antineoplastic

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis	Completed	NCT01745159	Phase 4	tacrolimus
2	Evaluation of Antibody Persistence Following 4 MenACWY Vaccinations	Completed	NCT02446691	Phase 4
3	Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers	Completed	NCT01843725	Phase 1	capecitabine;aflibercept;Capecitabine
4	Understanding Disparities in Healthcare and Primary Care Provider Quality	Completed	NCT02626910
5	Realizing Opportunities for Self Empowerment	Completed	NCT02087956	Not Applicable
6	Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes	Completed	NCT02038959	Not Applicable

Search NIH Clinical Center for Alzheimer Disease 12

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Genetic Tests for Alzheimer Disease 12

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Anatomical Context for Alzheimer Disease 12

MalaCards organs/tissues related to Alzheimer Disease 12:

⁴²

Testes, Breast, Bone

Sources

Publications for Alzheimer Disease 12

Articles related to Alzheimer Disease 12:

(show all 33)

#	Title	Authors	Year
1	Using the AD12-ICT rapid-format test to detect Wuchereria bancrofti circulating antigens in comparison to Og4C3-ELISA and nucleopore membrane filtration and microscopy techniques. ( 22392137 )	El-Moamly AA...Hafez MA	2012
2	Comparison of tests for the detection of circulating filarial antigen (Og4C3-ELISA and AD12-ICT) and ultrasound in diagnosis of lymphatic filariasis in individuals with microfilariae. ( 19722087 )	Rocha A...Furtado A	2009
3	Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to lymphokine-activated killer (LAK) cells. ( 15963548 )	Bottley G...Blair GE	2005
4	Intraperitoneal dissemination of Ad12-induced undifferentiated neuroectodermal hamster tumors: de novo methylation and transcription patterns of integrated viral and of cellular genes. ( 14609629 )	Hohlweg U...Doerfler W	2003
5	Overexpression of the adenovirus type 12 (Ad12) pTP or E1A gene facilitates Ad12 DNA replication in nonpermissive BHK21 hamster cells. ( 11581373 )	H?sel M...Doerfler W	2001
6	Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription. ( 10704340 )	Smirnov DA...Ricciardi RP	2000
7	Synthesis and turnover of beta2-microglobulin in Ad12-transformed cells defective in assembly and transport of class I major histocompatibility complex molecules. ( 8995269 )	Mey-Tal SV...Ehrlich R	1997
8	The first exon of Ad12 E1A excluding the transactivation domain mediates differential binding of COUP-TF and NF-kappa B to the MHC class I enhancer in transformed cells. ( 8552385 )	Kushner DB...Ricciardi RP	1996
9	Insufficient levels of NFIII and its low affinity for the origin of adenovirus type 12 (Ad12) DNA replication contribute to the abortive infection of BHK21 hamster cells by Ad12. ( 8892924 )	Schiedner G...Doerfler W	1996
10	Selective loss of unmethylated segments of integrated Ad12 genomes in revertants of the adenovirus type 12-transformed cell line T637. ( 8578863 )	Orend G...Doerfler W	1995
11	E1A oncogene of adenovirus-12 mediates trans-repression of MHC class I transcription in Ad5/Ad12 somatic hybrid transformed cells. ( 8053163 )	Ge R...Ricciardi RP	1994
12	The adenovirus e1a-associated p300 protein is differentially phosphorylated in ad12 e1a-compared to ad5 e1a-transformed rat-cells. ( 21559698 )	Pereira D...Graham F	1994
13	Altered host range phenotype of the transformation-defective Ad12 mutant CS-1 is due to deletions in the E1 region. ( 7928288 )	Opalka B...Holthausen HS	1994
14	Adenovirus 12-mediated down-regulation of the major histocompatibility complex (MHC) class I promoter: identification of a negative regulatory element responsive to Ad12 E1A. ( 7984430 )	Proffitt JL...Blair GE	1994
15	Immortalization of mouse bone marrow-derived mast cells with Ad12-SV40 virus. ( 7683224 )	Arora N...Metcalfe DD	1993
16	Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range. ( 1534849 )	Jelinek T...Graham FL	1992
17	Changes in NF-kappa B and ISGF3 DNA binding activities are responsible for differences in MHC and beta-IFN gene expression in Ad5- versus Ad12-transformed cells. ( 1756724 )	Nielsch U...Babiss LE	1991
18	The expression of Ad12 E1B 19K protein on the surface of adenovirus transformed and infected human cells. ( 2541391 )	Smith KJ...Grand RJ	1989
19	Arrangement and expression of integrated adenovirus type 12 DNA in the transformed hamster cell line HA12/7: amplification of Ad12 and c-myc DNAs and evidence for hybrid viral-cellular transcripts. ( 2773593 )	Jessberger R...Doerfler W	1989
20	Cellular protein differences between nontumorigenic Ad5 and tumorigenic Ad12 transformed mouse cells. ( 3727404 )	Eager KB...Ricciardi RP	1986
21	Structure of viral DNA in a rat cell line, GY1, transformed by Ad12 HindIII fragment-G. ( 3002026 )	Kudo S...Fujinaga K	1986
22	Transforming properties of a 15-kDa truncated Ad12 E1A gene product. ( 3014724 )	Jochemsen AG...van der Eb AJ	1986
23	How reliable is amino acid sequence homology in predicting similarity of structure and function of c-myc and Ad12 E1A oncogenic proteins? ( 3091845 )	Ghrist BF...Ricciardi RP	1986
24	Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. ( 2579430 )	Rhim JS...Aaronson SA	1985
25	Structure and function of adenovirus DNA binding protein: comparison of the amino acid sequences of the Ad5 and Ad12 proteins derived from the nucleotide sequence of the corresponding genes. ( 6308889 )	Kruijer W...Sussenbach JS	1983
26	Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. ( 6312680 )	Bos JL...van der Eb AJ	1983
27	The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a. ( 11894912 )	Bos JL...ten Wolde-Kraamwinkel HC	1983
28	Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids. ( 7101731 )	Bernards R...Van der Eb AJ	1982
29	Effector cells working for rejection of Ad12 tumors in mice. ( 6302452 )	Maeta Y...Hamada C	1982
30	The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets. ( 7326748 )	Bos JL...van Ormondt H	1981
31	Close association of virus-specific cell surface and H-2 antigens in Ad12-infected and -transformed mouse cells. ( 7231218 )	Maeta Y...Hamada C	1981
32	Structure and gene organization in the transformed Hind III-G fragment of Ad12. ( 6251973 )	Sugisaki H...Fujinaga K	1980
33	Susceptibility of Ad12-transformed S (+) and S (-) mouse cells to cell-mediated immunity in vitro. ( 530102 )	Maeta Y...Hamada C	1979

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Genes for Alzheimer Disease 12

Genes related to Alzheimer Disease 12 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AD12	Alzheimer Disease 12	Genetic Locus	58.25	Susceptibility factor ⁵⁸ GeneCards inferred via : Gene name (show sections)

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Variations for Alzheimer Disease 12

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Expression for Alzheimer Disease 12

Search GEO for disease gene expression data for Alzheimer Disease 12.

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Pathways for Alzheimer Disease 12

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GO Terms for Alzheimer Disease 12

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Sources for Alzheimer Disease 12

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹³ diseasecard

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¹⁶ DrugBank

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia