AD12
MCID: ALZ012
MIFTS: 27

Alzheimer Disease 12 (AD12)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 12

MalaCards integrated aliases for Alzheimer Disease 12:

Name: Alzheimer Disease 12 56 12 13 71
Alzheimer's Disease 12 12 15
Ad12 56 12
Alzheimer Disease, Familial, 12 56
Alzheimer Disease Familial 12 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110045
OMIM 56 611073
ICD10 32 G30
MedGen 41 C1970209
UMLS 71 C1970209

Summaries for Alzheimer Disease 12

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.

MalaCards based summary : Alzheimer Disease 12, also known as alzheimer's disease 12, is related to alzheimer disease and rabies. An important gene associated with Alzheimer Disease 12 is AD12 (Alzheimer Disease 12), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Metabolism of steroid hormones. Affiliated tissues include brain.

More information from OMIM: 611073

Related Diseases for Alzheimer Disease 12

Graphical network of the top 20 diseases related to Alzheimer Disease 12:



Diseases related to Alzheimer Disease 12

Symptoms & Phenotypes for Alzheimer Disease 12

Clinical features from OMIM:

611073

Drugs & Therapeutics for Alzheimer Disease 12

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Placebo-controlled Single Center Pilot Study of the Safety and Efficacy of Tralokinumab in Subjects With Moderate to Severe Alopecia Areata Completed NCT02684097 Phase 2 Tralokinumab;Placebo
2 Alzheimer Disease : Rehabilitation's Intervention at Home. A Preliminary Pilot Study. Terminated NCT01689948

Search NIH Clinical Center for Alzheimer Disease 12

Genetic Tests for Alzheimer Disease 12

Anatomical Context for Alzheimer Disease 12

MalaCards organs/tissues related to Alzheimer Disease 12:

40
Brain

Publications for Alzheimer Disease 12

Articles related to Alzheimer Disease 12:

(show all 18)
# Title Authors PMID Year
1
New Alzheimer's disease locus on chromosome 8. 56
16825432 2006
2
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein. 61
31424413 2019
3
ABCA7 loss-of-function variants, expression, and neurologic disease risk. 61
28097223 2017
4
Linguistic development in Alzheimer's disease: 12 months language training including use of a personal computer system: a pilot study. 61
21548856 2011
5
Neural cell adhesion molecule--description of a CSF ELISA method and evidence of reduced levels in selected neurological disorders. 61
20605643 2010
6
Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer's disease. 61
20524039 2010
7
Cigarette smoking and dementia: potential selection bias in the elderly. 61
18414087 2008
8
Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002. 61
14765518 2003
9
A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease. 61
14617718 2003
10
Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias. 61
12112084 2002
11
[Usefulness of SPECT images in helping radiologists understand brain diseases]. 61
11398344 2001
12
[Regional cerebral blood flow and cerebrospinal fluid amino acid analysis in elderly dementia]. 61
9866128 1998
13
Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease. 61
9436722 1998
14
The neuropsychological differentiation of patients with very mild Alzheimer's disease and/or major depression. 61
7594160 1995
15
A method for assessing the significance of abnormalities in HMPO brain SPECT images. 61
8294991 1994
16
Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged. 61
8236812 1993
17
The nucleus basalis of Meynert in multi-infarct (vascular) dementia. 61
3799146 1986
18
Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type. 61
3985585 1985

Variations for Alzheimer Disease 12

Expression for Alzheimer Disease 12

Search GEO for disease gene expression data for Alzheimer Disease 12.

Pathways for Alzheimer Disease 12

GO Terms for Alzheimer Disease 12

Biological processes related to Alzheimer Disease 12 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.32 LILRB1 CD300C
2 cellular response to lipopolysaccharide GO:0071222 9.26 STAR LILRB1
3 estrogen biosynthetic process GO:0006703 9.16 STAR DHRS11
4 testosterone biosynthetic process GO:0061370 8.96 STAR HSD17B3
5 steroid biosynthetic process GO:0006694 8.8 STAR HSD17B3 DHRS11

Sources for Alzheimer Disease 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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