Alzheimer Disease 13 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Alzheimer Disease 13

MalaCards integrated aliases for Alzheimer Disease 13:

Name: Alzheimer Disease 13 ⁵⁷ ¹² ⁷¹

Alzheimer's Disease 13 ¹² ¹⁵

Alzheimer Disease-13 ⁵⁷ ¹³

Ad13 ⁵⁷ ¹²

Alzheimer's Disease 13, Late Onset ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the nervous system

Other degenerative diseases of the nervous system

Alzheimer disease

External Ids:

Disease Ontology ¹² DOID:0110046

OMIM® ⁵⁷ 611152

ICD10 ³² G30

MedGen ⁴¹ C1970147

UMLS ⁷¹ C1970147

Sources

Summaries for Alzheimer Disease 13

Disease Ontology : ¹² An Alzheimer's disease that is characterized by an associated with variation in the region 1q21.

MalaCards based summary : Alzheimer Disease 13, also known as alzheimer's disease 13, is related to alzheimer disease and vici syndrome. An important gene associated with Alzheimer Disease 13 is AD13 (Alzheimer Disease-13), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Pyruvate metabolism. Affiliated tissues include brain.

More information from OMIM: 611152

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Related Diseases for Alzheimer Disease 13

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2	Alzheimer Disease 16
Alzheimer Disease 5	Alzheimer Disease 15
Alzheimer Disease 6	Alzheimer Disease 7
Alzheimer Disease 4	Alzheimer Disease 8
Alzheimer Disease 3	Alzheimer Disease 9
Alzheimer Disease 10	Alzheimer Disease 11
Alzheimer Disease 12	Alzheimer Disease 13
Alzheimer Disease 14	Alzheimer Disease 17
Alzheimer Disease 18	Alzheimer Disease 19
Alzheimer's Disease 1	Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 13 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	alzheimer disease	10.9
2	vici syndrome	10.0	TECPR2 GABARAPL1
3	parkinson disease 17	10.0	LDHB LDHA
4	methemoglobinemia	9.8	CYP2E1 CYB5A
5	amyloidosis, hereditary, transthyretin-related	9.5	NPPB HTT

Graphical network of the top 20 diseases related to Alzheimer Disease 13:

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Symptoms & Phenotypes for Alzheimer Disease 13

Clinical features from OMIM®:

611152 (Updated 05-Mar-2021)

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Drugs & Therapeutics for Alzheimer Disease 13

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 13

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Genetic Tests for Alzheimer Disease 13

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Anatomical Context for Alzheimer Disease 13

MalaCards organs/tissues related to Alzheimer Disease 13:

⁴⁰

Brain

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Publications for Alzheimer Disease 13

Articles related to Alzheimer Disease 13:

#	Title	Authors	PMID	Year
1	A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. ⁵⁷	Liu F...van Duijn CM	17564960	2007
2	Results of a high-resolution genome screen of 437 Alzheimer's disease families. ⁵⁷	Blacker D...NIMH Genetics Initiative Alzheimer's Disease Study Group	12490529	2003
3	Full genome screen for Alzheimer disease: stage II analysis. ⁵⁷	Myers A...Goate A	11857588	2002
4	Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland. ⁵⁷	Hiltunen M...Soininen H	11706108	2001
5	A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. ⁵⁷	Zubenko GS...Kaplan BB	9653640	1998
6	Isolation of soluble and insoluble PrP oligomers in the normal human brain. ⁶¹	Xiao X...Zou WQ	23070047	2012
7	Evaluation of human adenoviruses 38, 39, 40, and 41 as new serotypes. ⁶¹	Hierholzer JC...de Jong JC	3384629	1988

Sources

Genes for Alzheimer Disease 13

Genes related to Alzheimer Disease 13 (1 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AD13	Alzheimer Disease-13	Genetic Locus	58.33	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	TECPR2	Tectonin Beta-Propeller Repeat Containing 2	Protein Coding	6.27	DISEASES inferred ¹⁵
3	RPA1	Replication Protein A1	Protein Coding	5.31	DISEASES inferred ¹⁵
4	FAM107B	Family With Sequence Similarity 107 Member B	Protein Coding	5.19	DISEASES inferred ¹⁵
5	CYB5A	Cytochrome B5 Type A	Protein Coding	5.1	DISEASES inferred ¹⁵
6	LDHB	Lactate Dehydrogenase B	Protein Coding	4.96	DISEASES inferred ¹⁵
7	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	4.79	DISEASES inferred ¹⁵
8	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	4.71	DISEASES inferred ¹⁵
9	GABARAPL1	GABA Type A Receptor Associated Protein Like 1	Protein Coding	4.66	DISEASES inferred ¹⁵
10	LDHA	Lactate Dehydrogenase A	Protein Coding	4.26	DISEASES inferred ¹⁵
11	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	4.17	DISEASES inferred ¹⁵
12	NPPB	Natriuretic Peptide B	Protein Coding	4.08	DISEASES inferred ¹⁵
13	HTT	Huntingtin	Protein Coding	3.96	DISEASES inferred ¹⁵
14	LOX	Lysyl Oxidase	Protein Coding	3.85	DISEASES inferred ¹⁵

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Variations for Alzheimer Disease 13

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Expression for Alzheimer Disease 13

Search GEO for disease gene expression data for Alzheimer Disease 13.

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Pathways for Alzheimer Disease 13

Pathways related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Senescence and Autophagy in Cancer ¹	11.36	MAP1LC3A GABARAPL2 GABARAPL1
2	Pyruvate metabolism ³⁶ Show member pathways methylglyoxal degradation I ¹ methylglyoxal degradation VI ¹	10.94	LDHB LDHA
3	Propanoate metabolism ³⁶	10.79	LDHB LDHA
4	Macroautophagy ⁶⁵ Show member pathways Autophagy - other ³⁶	10.79	MAP1LC3A GABARAPL2 GABARAPL1
5	Metabolic States and Circadian Oscillators ⁶³ Show member pathways lactate fermentation (reoxidation of cytosolic NADH) ¹	10.03	LDHB LDHA

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GO Terms for Alzheimer Disease 13

Cellular components related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	9.33	MAP1LC3A CYP2E1 CYB5A
2	autophagosome membrane	GO:0000421	9.13	MAP1LC3A GABARAPL2 GABARAPL1
3	autophagosome	GO:0005776	8.92	MAP1LC3A HTT GABARAPL2 GABARAPL1

Biological processes related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.8	LOX LDHB LDHA CYP2E1 CYB5A
2	autophagy	GO:0006914	9.56	TECPR2 MAP1LC3A GABARAPL2 GABARAPL1
3	macroautophagy	GO:0016236	9.54	MAP1LC3A GABARAPL2 GABARAPL1
4	autophagosome assembly	GO:0000045	9.5	MAP1LC3A GABARAPL2 GABARAPL1
5	pyruvate metabolic process	GO:0006090	9.46	LDHB LDHA
6	carboxylic acid metabolic process	GO:0019752	9.43	LDHB LDHA
7	autophagy of mitochondrion	GO:0000422	9.33	MAP1LC3A GABARAPL2 GABARAPL1
8	autophagosome maturation	GO:0097352	9.13	MAP1LC3A GABARAPL2 GABARAPL1
9	cellular response to nitrogen starvation	GO:0006995	8.8	MAP1LC3A GABARAPL2 GABARAPL1

Molecular functions related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.56	LOX LDHB LDHA CYP2E1
2	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0016616	9.32	LDHB LDHA
3	GABA receptor binding	GO:0050811	9.16	GABARAPL2 GABARAPL1
4	L-lactate dehydrogenase activity	GO:0004459	8.96	LDHB LDHA
5	beta-tubulin binding	GO:0048487	8.8	HTT GABARAPL2 GABARAPL1

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Sources for Alzheimer Disease 13

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Alzheimer Disease 13 (AD13)

Aliases & Classifications for Alzheimer Disease 13

MalaCards integrated aliases for Alzheimer Disease 13:

Classifications:

External Ids:

Summaries for Alzheimer Disease 13

Related Diseases for Alzheimer Disease 13

Diseases in the Alzheimer Disease family:

Diseases related to Alzheimer Disease 13 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Alzheimer Disease 13:

Symptoms & Phenotypes for Alzheimer Disease 13

Clinical features from OMIM®:

Drugs & Therapeutics for Alzheimer Disease 13

Genetic Tests for Alzheimer Disease 13

Anatomical Context for Alzheimer Disease 13

MalaCards organs/tissues related to Alzheimer Disease 13:

Publications for Alzheimer Disease 13

Articles related to Alzheimer Disease 13:

Genes for Alzheimer Disease 13

Genes related to Alzheimer Disease 13 (1 elite genes):

Variations for Alzheimer Disease 13

Expression for Alzheimer Disease 13

Pathways for Alzheimer Disease 13

Pathways related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

GO Terms for Alzheimer Disease 13

Cellular components related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

Biological processes related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

Molecular functions related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

Sources for Alzheimer Disease 13