AD13
MCID: ALZ059
MIFTS: 27

Alzheimer Disease 13 (AD13)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 13

MalaCards integrated aliases for Alzheimer Disease 13:

Name: Alzheimer Disease 13 56 12 71
Alzheimer's Disease 13 12 15
Alzheimer Disease-13 56 13
Ad13 56 12
Alzheimer's Disease 13, Late Onset 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110046
OMIM 56 611152
ICD10 32 G30
MedGen 41 C1970147
UMLS 71 C1970147

Summaries for Alzheimer Disease 13

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 1q21.

MalaCards based summary : Alzheimer Disease 13, also known as alzheimer's disease 13, is related to alzheimer disease and granulomatous amebic encephalitis. An important gene associated with Alzheimer Disease 13 is AD13 (Alzheimer Disease-13), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Macroautophagy. Affiliated tissues include brain.

More information from OMIM: 611152

Related Diseases for Alzheimer Disease 13

Graphical network of the top 20 diseases related to Alzheimer Disease 13:



Diseases related to Alzheimer Disease 13

Symptoms & Phenotypes for Alzheimer Disease 13

Clinical features from OMIM:

611152

Drugs & Therapeutics for Alzheimer Disease 13

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 13

Genetic Tests for Alzheimer Disease 13

Anatomical Context for Alzheimer Disease 13

MalaCards organs/tissues related to Alzheimer Disease 13:

40
Brain

Publications for Alzheimer Disease 13

Articles related to Alzheimer Disease 13:

# Title Authors PMID Year
1
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. 56
17564960 2007
2
Results of a high-resolution genome screen of 437 Alzheimer's disease families. 56
12490529 2003
3
Full genome screen for Alzheimer disease: stage II analysis. 56
11857588 2002
4
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland. 56
11706108 2001
5
A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. 56
9653640 1998
6
Isolation of soluble and insoluble PrP oligomers in the normal human brain. 61
23070047 2012
7
Evaluation of human adenoviruses 38, 39, 40, and 41 as new serotypes. 61
3384629 1988

Variations for Alzheimer Disease 13

Expression for Alzheimer Disease 13

Search GEO for disease gene expression data for Alzheimer Disease 13.

Pathways for Alzheimer Disease 13

Pathways related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.36 MAP1LC3A GABARAPL2 GABARAPL1
2
Show member pathways
11.13 MAP1LC3A GABARAPL2 GABARAPL1
3
Show member pathways
10.94 LDHB LDHA
4 10.79 LDHB LDHA
5
Show member pathways
9.7 LDHB LDHA

GO Terms for Alzheimer Disease 13

Cellular components related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10 TECPR2 NPPB MAP1LC3A LDHB LDHA HTT
2 organelle membrane GO:0031090 9.33 MAP1LC3A CYP2E1 CYB5A
3 autophagosome membrane GO:0000421 9.13 MAP1LC3A GABARAPL2 GABARAPL1
4 autophagosome GO:0005776 8.92 MAP1LC3A HTT GABARAPL2 GABARAPL1

Biological processes related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 LOX LDHB LDHA CYP2E1 CYB5A
2 autophagy GO:0006914 9.56 TECPR2 MAP1LC3A GABARAPL2 GABARAPL1
3 macroautophagy GO:0016236 9.54 MAP1LC3A GABARAPL2 GABARAPL1
4 autophagosome assembly GO:0000045 9.5 MAP1LC3A GABARAPL2 GABARAPL1
5 pyruvate metabolic process GO:0006090 9.46 LDHB LDHA
6 carboxylic acid metabolic process GO:0019752 9.43 LDHB LDHA
7 autophagy of mitochondrion GO:0000422 9.33 MAP1LC3A GABARAPL2 GABARAPL1
8 autophagosome maturation GO:0097352 9.13 MAP1LC3A GABARAPL2 GABARAPL1
9 cellular response to nitrogen starvation GO:0006995 8.8 MAP1LC3A GABARAPL2 GABARAPL1

Molecular functions related to Alzheimer Disease 13 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.62 LOX LDHB LDHA CYP2E1
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 LDHB LDHA
3 GABA receptor binding GO:0050811 9.16 GABARAPL2 GABARAPL1
4 L-lactate dehydrogenase activity GO:0004459 8.96 LDHB LDHA
5 beta-tubulin binding GO:0048487 8.8 HTT GABARAPL2 GABARAPL1

Sources for Alzheimer Disease 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....