AD15
MCID: ALZ061
MIFTS: 31

Alzheimer Disease 15 (AD15)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 15

MalaCards integrated aliases for Alzheimer Disease 15:

Name: Alzheimer Disease 15 56 12 71
Alzheimer's Disease 15 12 15
Alzheimer Disease-15 56 13
Ad15 56 12
Alzheimer's Disease 15, Late Onset 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110048
OMIM 56 611155
ICD10 32 G30
MedGen 41 C1970143
UMLS 71 C1970143

Summaries for Alzheimer Disease 15

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variations in the region 3q22-q24.

MalaCards based summary : Alzheimer Disease 15, also known as alzheimer's disease 15, is related to alzheimer disease and alzheimer disease 19. An important gene associated with Alzheimer Disease 15 is AD15 (Alzheimer Disease-15), and among its related pathways/superpathways are Mitotic G1-G1/S phases and PI3K-Akt signaling pathway. Affiliated tissues include t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 611155

Related Diseases for Alzheimer Disease 15

Graphical network of the top 20 diseases related to Alzheimer Disease 15:



Diseases related to Alzheimer Disease 15

Symptoms & Phenotypes for Alzheimer Disease 15

Clinical features from OMIM:

611155

GenomeRNAi Phenotypes related to Alzheimer Disease 15 according to GeneCards Suite gene sharing:

26 (showing 25, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.74 PPP2R3A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.74 NOTCH3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.74 CCND2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.74 PPP2R3A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.74 NOTCH3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.74 NOTCH3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.74 NOTCH3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.74 PPP2R3A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.74 CCND2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.74 PPP6C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.74 CCND2 NOTCH3 PPP2R3A PPP6C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.74 PPP2R3A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.74 NOTCH3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.74 PPP6C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.74 NOTCH3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.74 NOTCH3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.74 PPP6C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.74 PPP6C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.74 CCND2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.74 PPP6C
21 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.74 PPP6C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.74 CCND2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.74 NOTCH3
24 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.7 CDK4 GJA1 MINK1 PPME1 PPP2CA PPP2R3A
25 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 8.96 CDK9 INSRR

MGI Mouse Phenotypes related to Alzheimer Disease 15:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.86 CDK4 GJA1 JAG2 MCL1 NOTCH3 PPP2CA
2 integument MP:0010771 9.81 CDK4 CDK9 GJA1 GOLPH3 JAG2 MCL1
3 mortality/aging MP:0010768 9.77 CCND2 CDK4 CDK9 ELANE GJA1 INSRR
4 reproductive system MP:0005389 9.32 CCND2 CDK4 CDK9 GJA1 GOLPH3 INSRR

Drugs & Therapeutics for Alzheimer Disease 15

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Therapeutic Role of Transcranial Direct Current Stimulation (tDCS) in Alzheimer Patients, Double Blind Placebo Controlled Clinical Trial Completed NCT03313518

Search NIH Clinical Center for Alzheimer Disease 15

Genetic Tests for Alzheimer Disease 15

Anatomical Context for Alzheimer Disease 15

MalaCards organs/tissues related to Alzheimer Disease 15:

40
T Cells

Publications for Alzheimer Disease 15

Articles related to Alzheimer Disease 15:

(showing 14, show less)
# Title Authors PMID Year
1
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. 56
17564960 2007
2
Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals. 61
30561665 2019
3
O-GlcNAc cycling shows neuroprotective potential in C. elegans models of neurodegenerative disease. 61
24744983 2013
4
Characterization of Alcaligenes faecalis strain AD15 indicating biocontrol activity against plant pathogens. 61
23759862 2013
5
Genetic alteration in oral squamous cell carcinoma detected by arbitrarily primed polymerase chain reaction. 61
22292655 2011
6
Molecular epidemiology of adenovirus strains isolated from patients with ocular disease in the area of Thessaloniki, Greece (1998-2002). 61
15648067 2005
7
Serological and genetic characterisation of a unique strain of adenovirus involved in an outbreak of epidemic keratoconjunctivitis. 61
15047747 2004
8
Mapping of epitopes on the fiber knobs of human adenovirus serotypes 8 and 15. 61
11937773 2002
9
Rapid detection and typing of oculopathogenic strain of subgenus D adenoviruses by fiber-based PCR and restriction enzyme analysis. 61
11481265 2001
10
Recombinant fibre proteins of human adenoviruses Ad9, Ad15 and Ad19: localization of the haemagglutination properties and the type-specific determinant. 61
9017826 1997
11
The use of a metal detector to locate ingested metallic foreign bodies in children. 61
8894862 1996
12
Immunological adenovirus variant strains of subgenus D: comparison of the hexon and fiber sequences. 61
7491756 1995
13
Characterization of adenovirus 15/H9 intermediate strains. 61
2982756 1985
14
Different interferon-inducing ability of human adenovirus types in chick embryo cells. 61
6195901 1983

Variations for Alzheimer Disease 15

Expression for Alzheimer Disease 15

Search GEO for disease gene expression data for Alzheimer Disease 15.

Pathways for Alzheimer Disease 15

Pathways related to Alzheimer Disease 15 according to GeneCards Suite gene sharing:

(showing 14, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 PPP2R3B PPP2CA CDK4 CCND2
2
Show member pathways
12.33 PPP2R3B PPP2R3A PPP2CA NOTCH3 MCL1 CDK4
3 12.25 PPP2CA CDK9 CDK4 CCND2
4
Show member pathways
11.98 PPP2CA INSRR CDK4 CCND2
5
Show member pathways
11.92 PPP2R3B PPP2R3A PPP2CA CCND2
6
Show member pathways
11.9 PPP2R3B PPP2R3A PPP2CA CDK4 CCND2
7
Show member pathways
11.8 PPP2R3B PPP2R3A PPP2CA
8 11.78 PPP2R3B PPP2R3A PPP2CA
9
Show member pathways
11.59 PPP2R3B PPP2R3A PPP2CA
10 11.57 PPP2R3B PPP2R3A PPP2CA
11 11.3 PPP2R3B PPP2R3A PPP2CA
12
Show member pathways
11.27 PPP2R3B PPP2R3A PPP2CA CDK4 CCND2
13 11.05 PPP2R3B PPP2R3A PPP2CA
14 10.94 CDK9 CDK4 CCND2

GO Terms for Alzheimer Disease 15

Cellular components related to Alzheimer Disease 15 according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.13 CDK9 CDK4 CCND2
2 protein phosphatase type 2A complex GO:0000159 8.8 PPP2R3B PPP2R3A PPP2CA

Biological processes related to Alzheimer Disease 15 according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.55 MINK1 INSRR CDK9 CDK4 CCND2
2 negative regulation of cell cycle arrest GO:0071157 9.32 CDK9 CDK4
3 response to lead ion GO:0010288 9.26 PPP2CA CDK4
4 protein dephosphorylation GO:0006470 9.26 PPP6C PPP2R3B PPP2R3A PPP2CA
5 regulation of phosphoprotein phosphatase activity GO:0043666 8.92 TIPRL PPP2R3B PPP2R3A PPME1

Molecular functions related to Alzheimer Disease 15 according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.09 TIPRL PPP6C PPP2R3B PPP2R3A PPP2CA PPME1
2 protein kinase activity GO:0004672 9.65 MINK1 INSRR CDK9 CDK4 CCND2
3 protein serine/threonine phosphatase activity GO:0004722 9.13 PPP6C PPP2R3B PPP2CA
4 protein phosphatase regulator activity GO:0019888 8.8 PPP2R3B PPP2R3A PPME1

Sources for Alzheimer Disease 15

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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