AD16
MCID: ALZ014
MIFTS: 26

Alzheimer Disease 16 (AD16)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Alzheimer Disease 16

MalaCards integrated aliases for Alzheimer Disease 16:

Name: Alzheimer Disease 16 57 12 71
Ad16 57 11 75
Alzheimer's Disease 16 11 14
Alzheimer's Disease 16, Late Onset 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0110036
OMIM® 57 300756
MedGen 40 C2677888
UMLS 71 C2677888

Summaries for Alzheimer Disease 16

Disease Ontology: 11 An Alzheimer's disease that is characterized by an associated with a risk allele in in the PCDH11X gene on chromosome Xq21.3.

MalaCards based summary: Alzheimer Disease 16, also known as ad16, is related to amyloidosis and apparent mineralocorticoid excess. An important gene associated with Alzheimer Disease 16 is AD16 (Alzheimer Disease 16), and among its related pathways/superpathways are FOXO-mediated transcription and Glucocorticoid receptor regulatory network. Affiliated tissues include brain and heart.

Wikipedia: 75 Alzheimer disease 16 is a protein that in humans is encoded by the AD16... more...

More information from OMIM: 300756

Related Diseases for Alzheimer Disease 16

Diseases in the Late-Onset Familial Alzheimer Disease family:

Alzheimer Disease, Familial, 1 Alzheimer Disease 2
Alzheimer Disease 16 Alzheimer Disease 5
Alzheimer Disease 15 Alzheimer Disease 6
Alzheimer Disease 7 Alzheimer Disease 4
Alzheimer Disease 8 Alzheimer Disease 3
Alzheimer Disease 9 Alzheimer Disease 10
Alzheimer Disease 11 Alzheimer Disease 12
Alzheimer Disease 13 Alzheimer Disease 14
Alzheimer Disease 17 Alzheimer Disease 18
Alzheimer Disease 19 Alzheimer's Disease 1
Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 16 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 amyloidosis 10.0
2 apparent mineralocorticoid excess 9.9 POMC ENSG00000275987
3 mediastinal lipomatosis 9.8 POMC NR3C1
4 ectopic cushing syndrome 9.8 POMC NR3C1
5 ovarian serous adenofibroma 9.8 POMC NR3C1
6 pituitary-dependent cushing's disease 9.8 POMC NR3C1
7 corticosteroid-binding globulin deficiency 9.8 POMC NR3C1
8 acute stress disorder 9.8 POMC NR3C1
9 atypical depressive disorder 9.8 POMC NR3C1
10 nelson syndrome 9.8 POMC NR3C1
11 postpartum depression 9.8 POMC NR3C1
12 skin atrophy 9.8 POMC NR3C1
13 acth-secreting pituitary adenoma 9.8 POMC NR3C1
14 pituitary adenoma 9.8 POMC NR3C1
15 hyperaldosteronism, familial, type i 9.8 POMC NR3C1
16 adult syndrome 9.8 POMC NR3C1
17 endogenous depression 9.8 POMC NR3C1
18 adrenal cortex disease 9.8 POMC NR3C1
19 liddle syndrome 1 9.8 POMC NR3C1
20 adrenal gland disease 9.8 POMC NR3C1
21 post-traumatic stress disorder 9.8 POMC NR3C1
22 chronic fatigue syndrome 9.7 POMC NR3C1
23 mental depression 9.7 POMC NR3C1
24 hyperandrogenism 9.7 POMC NR3C1
25 hypokalemia 9.7 POMC NR3C1
26 lipoid congenital adrenal hyperplasia 9.7 POMC NR3C1
27 acquired immunodeficiency syndrome 9.7 POMC NR3C1
28 rhinitis 9.6 POMC NR3C1
29 mood disorder 9.6 POMC NR3C1
30 conn's syndrome 9.5 POMC NR3C1 ENSG00000275987
31 hypoglycemia 9.5 POMC NR3C1

Graphical network of the top 20 diseases related to Alzheimer Disease 16:



Diseases related to Alzheimer Disease 16

Symptoms & Phenotypes for Alzheimer Disease 16

Clinical features from OMIM®:

300756 (Updated 08-Dec-2022)

Drugs & Therapeutics for Alzheimer Disease 16

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Alzheimer's Disease Recruiting NCT04100889
2 A Randomized, Double-blind, Sham-controlled, Adaptive- Design Pivotal Study of Sensory Stimulation in Subjects With Alzheimer's Disease (Hope Study, CA-0011) Not yet recruiting NCT05637801

Search NIH Clinical Center for Alzheimer Disease 16

Genetic Tests for Alzheimer Disease 16

Anatomical Context for Alzheimer Disease 16

Organs/tissues related to Alzheimer Disease 16:

MalaCards : Brain, Heart

Publications for Alzheimer Disease 16

Articles related to Alzheimer Disease 16:

(show all 42)
# Title Authors PMID Year
1
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. 57
19136949 2009
2
Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia. 62
36334269 2022
3
Dissection of the Functional Mechanism of Human Gut Bacterial Strain AD16 by Secondary Metabolites' Identification, Network Pharmacology, and Experimental Validation. 62
34803669 2021
4
Compound AD16 Reduces Amyloid Plaque Deposition and Modifies Microglia in a Transgenic Mouse Model of Alzheimer's Disease. 62
33344892 2020
5
Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition. 62
32309804 2020
6
Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang). 62
29287388 2018
7
A neural network underlying intentional emotional facial expression in neurodegenerative disease. 62
28373956 2017
8
Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders. 62
25581033 2015
9
Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases. 62
24453364 2014
10
Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome. 62
21315400 2011
11
The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity. 62
21068234 2011
12
Adenovirus interactions with CD46 on transgenic mouse erythrocytes. 62
20347110 2010
13
Structural variations in species B adenovirus fibers impact CD46 association. 62
18524830 2008
14
Adenoviruses 16 and CV23 efficiently transduce human low-passage brain tumor and cancer stem cells. 62
17878898 2007
15
Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients. 62
17082793 2007
16
A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells. 62
17020944 2006
17
PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. 62
16272512 2005
18
CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines. 62
16103178 2005
19
Histological studies of selected organs of mice experimentally infected with Acanthamoeba spp. 62
16228950 2005
20
In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with their in vivo immunogenicity. 62
15661134 2005
21
Sequence polymorphism in the E3 7.7K ORF of subspecies B1 human adenoviruses. 62
15567028 2005
22
Characterization of species B adenoviruses isolated from fecal specimens taken from poliomyelitis-suspected cases. 62
15494264 2004
23
Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. 62
15610606 2004
24
The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. 62
15078926 2004
25
A metabolic imaging severity rating scale for the assessment of cognitive impairment. 62
12819409 2003
26
Type-specific identification of human adenovirus 3, 7, and 21 by a multiplex PCR assay. 62
11468741 2001
27
Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load. 62
11415893 2001
28
Improved adenovirus vectors for infection of cardiovascular tissues. 62
11238859 2001
29
Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber. 62
11263771 2001
30
Species-specific identification of human adenoviruses by a multiplex PCR assay. 62
11060077 2000
31
An autopsy-verified study of the effect of education on degenerative dementia. 62
10581224 1999
32
Genetic variability of hexon loops 1 and 2 between seven genome types of adenovirus serotype 7. 62
10542023 1999
33
Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia. 62
9152721 1997
34
Hydropathic characteristics of adenovirus hexons. 62
9267445 1997
35
The diagnosis of Alzheimer's disease: a question of image? 62
7989291 1994
36
Nucleic acid hybridization for detection of cell culture-amplified adenovirus. 62
3230138 1988
37
Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47). 62
2844918 1988
38
Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease. 62
3491344 1986
39
Immunological and biochemical characterization of human adenoviruses from subgenus B. I. Antigenic relationships. 62
3985807 1985
40
Immunological and biochemical characterization of human adenoviruses from subgenus B. II. DNA restriction analysis. 62
2985033 1985
41
Analysis of human cancer DNA's for DNA sequence of human adenovirus serotypes 3, 7, 11, 14, 16, and 21 in group B1. 62
573174 1979
42
Transforming region of group A, B, and C adenoviruses: DNA homology studies with twenty-nine human adenovirus serotypes. 62
448795 1979

Variations for Alzheimer Disease 16

Expression for Alzheimer Disease 16

Search GEO for disease gene expression data for Alzheimer Disease 16.

Pathways for Alzheimer Disease 16

GO Terms for Alzheimer Disease 16

Sources for Alzheimer Disease 16

2 CDC
6 CNVD
8 Cosmic
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10 DGIdb
16 EFO
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18 FMA
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29 HMDB
30 HPO
31 ICD10
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56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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