AD16
MCID: ALZ014
MIFTS: 23

Alzheimer Disease 16 (AD16)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 16

MalaCards integrated aliases for Alzheimer Disease 16:

Name: Alzheimer Disease 16 57 13 70
Alzheimer's Disease 16 12 15
Ad16 57 12
Alzheimer's Disease 16, Late Onset 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110036
OMIM® 57 300756
MedGen 41 C2677888
UMLS 70 C2677888

Summaries for Alzheimer Disease 16

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with a risk allele in in the PCDH11X gene on chromosome Xq21.3.

MalaCards based summary : Alzheimer Disease 16, also known as alzheimer's disease 16, is related to alzheimer disease and ectopic cushing syndrome. An important gene associated with Alzheimer Disease 16 is AD16 (Alzheimer Disease 16), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. Affiliated tissues include brain and heart.

More information from OMIM: 300756

Related Diseases for Alzheimer Disease 16

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 15
Alzheimer Disease 6 Alzheimer Disease 7
Alzheimer Disease 4 Alzheimer Disease 8
Alzheimer Disease 3 Alzheimer Disease 9
Alzheimer Disease 10 Alzheimer Disease 11
Alzheimer Disease 12 Alzheimer Disease 13
Alzheimer Disease 14 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 16 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 11.0
2 ectopic cushing syndrome 9.8 POMC NR3C1
3 ovarian serous adenofibroma 9.8 POMC NR3C1
4 pituitary-dependent cushing's disease 9.8 POMC NR3C1
5 atypical depressive disorder 9.8 POMC NR3C1
6 corticosteroid-binding globulin deficiency 9.8 POMC NR3C1
7 nelson syndrome 9.8 POMC NR3C1
8 acute stress disorder 9.8 POMC NR3C1
9 hyperaldosteronism, familial, type i 9.8 POMC NR3C1
10 endogenous depression 9.8 POMC NR3C1
11 adult syndrome 9.8 POMC NR3C1
12 acth-secreting pituitary adenoma 9.8 POMC NR3C1
13 postpartum depression 9.8 POMC NR3C1
14 adrenal gland disease 9.8 POMC NR3C1
15 mental depression 9.8 POMC NR3C1
16 primary pigmented nodular adrenocortical disease 9.8 POMC NR3C1
17 hypokalemia 9.8 POMC NR3C1
18 chronic fatigue syndrome 9.8 POMC NR3C1
19 apparent mineralocorticoid excess 9.8 NR3C1 ENSG00000273516
20 post-traumatic stress disorder 9.8 POMC NR3C1
21 pseudohermaphroditism 9.8 POMC NR3C1
22 acquired immunodeficiency syndrome 9.7 POMC NR3C1
23 rhinitis 9.7 POMC NR3C1
24 mood disorder 9.7 POMC NR3C1
25 conn's syndrome 9.7 POMC NR3C1
26 hypoglycemia 9.7 POMC NR3C1
27 anxiety 9.6 POMC NR3C1
28 familial hypercholesterolemia 9.6 POMC NR3C1
29 amelogenesis imperfecta 9.5 POMC NR3C1

Graphical network of the top 20 diseases related to Alzheimer Disease 16:



Diseases related to Alzheimer Disease 16

Symptoms & Phenotypes for Alzheimer Disease 16

Clinical features from OMIM®:

300756 (Updated 05-Apr-2021)

Drugs & Therapeutics for Alzheimer Disease 16

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 16

Genetic Tests for Alzheimer Disease 16

Anatomical Context for Alzheimer Disease 16

MalaCards organs/tissues related to Alzheimer Disease 16:

40
Brain, Heart

Publications for Alzheimer Disease 16

Articles related to Alzheimer Disease 16:

(show all 33)
# Title Authors PMID Year
1
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. 57
19136949 2009
2
Compound AD16 Reduces Amyloid Plaque Deposition and Modifies Microglia in a Transgenic Mouse Model of Alzheimer's Disease. 61
33344892 2020
3
Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang). 61
29287388 2018
4
Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders. 61
25581033 2015
5
Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases. 61
24453364 2014
6
Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome. 61
21315400 2011
7
The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity. 61
21068234 2011
8
Adenovirus interactions with CD46 on transgenic mouse erythrocytes. 61
20347110 2010
9
Structural variations in species B adenovirus fibers impact CD46 association. 61
18524830 2008
10
Adenoviruses 16 and CV23 efficiently transduce human low-passage brain tumor and cancer stem cells. 61
17878898 2007
11
Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients. 61
17082793 2007
12
A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells. 61
17020944 2006
13
PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. 61
16272512 2005
14
CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines. 61
16103178 2005
15
Histological studies of selected organs of mice experimentally infected with Acanthamoeba spp. 61
16228950 2005
16
In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with their in vivo immunogenicity. 61
15661134 2005
17
Sequence polymorphism in the E3 7.7K ORF of subspecies B1 human adenoviruses. 61
15567028 2005
18
Characterization of species B adenoviruses isolated from fecal specimens taken from poliomyelitis-suspected cases. 61
15494264 2004
19
Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. 61
15610606 2004
20
The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. 61
15078926 2004
21
A metabolic imaging severity rating scale for the assessment of cognitive impairment. 61
12819409 2003
22
Type-specific identification of human adenovirus 3, 7, and 21 by a multiplex PCR assay. 61
11468741 2001
23
Improved adenovirus vectors for infection of cardiovascular tissues. 61
11238859 2001
24
Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber. 61
11263771 2001
25
Species-specific identification of human adenoviruses by a multiplex PCR assay. 61
11060077 2000
26
Genetic variability of hexon loops 1 and 2 between seven genome types of adenovirus serotype 7. 61
10542023 1999
27
Hydropathic characteristics of adenovirus hexons. 61
9267445 1997
28
Nucleic acid hybridization for detection of cell culture-amplified adenovirus. 61
3230138 1988
29
Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47). 61
2844918 1988
30
Immunological and biochemical characterization of human adenoviruses from subgenus B. I. Antigenic relationships. 61
3985807 1985
31
Immunological and biochemical characterization of human adenoviruses from subgenus B. II. DNA restriction analysis. 61
2985033 1985
32
Analysis of human cancer DNA's for DNA sequence of human adenovirus serotypes 3, 7, 11, 14, 16, and 21 in group B1. 61
573174 1979
33
Transforming region of group A, B, and C adenoviruses: DNA homology studies with twenty-nine human adenovirus serotypes. 61
448795 1979

Variations for Alzheimer Disease 16

Expression for Alzheimer Disease 16

Search GEO for disease gene expression data for Alzheimer Disease 16.

Pathways for Alzheimer Disease 16

Pathways related to Alzheimer Disease 16 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 POMC NR3C1

GO Terms for Alzheimer Disease 16

Sources for Alzheimer Disease 16

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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