AD17
MCID: ALZ031
MIFTS: 30

Alzheimer Disease 17 (AD17)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 17

MalaCards integrated aliases for Alzheimer Disease 17:

Name: Alzheimer Disease 17 56 12 13 71
Alzheimer's Disease 17 12 15
Ad17 56 12
Alzheimer Disease 17, Late-Onset 56
Alzheimer Disease 17, Late Onset 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110049
OMIM 56 615080
UMLS 71 C3554452

Summaries for Alzheimer Disease 17

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with mutations in the gene TREM2.

MalaCards based summary : Alzheimer Disease 17, also known as alzheimer's disease 17, is related to alzheimer disease and nodular tenosynovitis. An important gene associated with Alzheimer Disease 17 is AD17 (Alzheimer Disease 17), and among its related pathways/superpathways is Microglia Activation During Neuroinflammation: Microglia Polarization. Affiliated tissues include skin and brain, and related phenotypes are Increased shRNA abundance and hematopoietic system

More information from OMIM: 615080

Related Diseases for Alzheimer Disease 17

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 6
Alzheimer Disease 7 Alzheimer Disease 4
Alzheimer Disease 8 Alzheimer Disease 3
Alzheimer Disease 9 Alzheimer Disease 10
Alzheimer Disease 11 Alzheimer Disease 12
Alzheimer Disease 13 Alzheimer Disease 14
Alzheimer Disease 15 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 17 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 11.4
2 nodular tenosynovitis 10.3 S100A9 CD68
3 xanthogranulomatous cholecystitis 10.3 S100A9 CD68
4 virus associated hemophagocytic syndrome 10.2 IL4 CD68
5 congenital granular cell tumor 10.2 S100A9 CD68
6 blepharoconjunctivitis 10.1 IL4 EDA
7 middle ear adenocarcinoma 10.1 CD68 AIF1
8 pouchitis 10.1 S100A9 IL1RN
9 adult xanthogranuloma 10.1 S100A9 CD68
10 middle ear carcinoma 10.0 CD68 AIF1
11 mucocutaneous leishmaniasis 9.9 IL4 APOE
12 hypersensitivity reaction type iv disease 9.9 IL4 IL1RN CD68
13 lumbosacral plexus lesion 9.8 RBFOX3 AIF1
14 cardiac rupture 9.8 S100A9 PLAT
15 encephalomalacia 9.7 RBFOX3 CD68 AIF1
16 subleukemic leukemia 9.7 RBFOX3 EDA AIF1
17 cerebral degeneration 9.6 RBFOX3 DLG4 APOE
18 relapsing-remitting multiple sclerosis 9.6 IL4 IL1RN APOE
19 dementia, lewy body 9.5 RBFOX3 APOE AIF1
20 toxic encephalopathy 9.3 RBFOX3 DLG4 APOE AIF1
21 pick disease of brain 9.3 RBFOX3 DLG4 APOE AIF1
22 occlusion precerebral artery 9.3 RBFOX3 PLAT AIF1
23 carotid artery occlusion 9.3 RBFOX3 PLAT AIF1
24 spastic paraplegia 24, autosomal recessive 9.2 PLAT AIF1
25 stroke, ischemic 8.8 RBFOX3 PLAT APOE AIF1

Graphical network of the top 20 diseases related to Alzheimer Disease 17:



Diseases related to Alzheimer Disease 17

Symptoms & Phenotypes for Alzheimer Disease 17

Clinical features from OMIM:

615080

GenomeRNAi Phenotypes related to Alzheimer Disease 17 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 APC IL1RN IL4 KCNA2

MGI Mouse Phenotypes related to Alzheimer Disease 17:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 AIF1 APC APOE CD68 DLG4 HVCN1
2 immune system MP:0005387 9.7 AIF1 APC APOE CD68 DLG4 HVCN1
3 skeleton MP:0005390 9.28 AIF1 APC APOE CD68 DLG4 IL1RN

Drugs & Therapeutics for Alzheimer Disease 17

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 17

Genetic Tests for Alzheimer Disease 17

Anatomical Context for Alzheimer Disease 17

MalaCards organs/tissues related to Alzheimer Disease 17:

40
Skin, Brain

Publications for Alzheimer Disease 17

Articles related to Alzheimer Disease 17:

(show all 28)
# Title Authors PMID Year
1
Missense variant in TREML2 protects against Alzheimer's disease. 56
24439484 2014
2
TREM2 and neurodegenerative disease. 56
24131184 2013
3
TREM2 and neurodegenerative disease. 56
24131183 2013
4
TREM2 and neurodegenerative disease. 56
24131185 2013
5
TREM2 and neurodegenerative disease. 56
24131186 2013
6
TREM2 and neurodegenerative disease. 56
24131187 2013
7
TREM2 and neurodegenerative disease. 56
24131188 2013
8
TREM2 and neurodegenerative disease. 56
24143816 2013
9
Variant of TREM2 associated with the risk of Alzheimer's disease. 56
23150908 2013
10
TREM2 variants in Alzheimer's disease. 56
23150934 2013
11
Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition. 61
29477284 2018
12
ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways. 61
28004780 2016
13
DNA variation and polymorphism in Tunisian plum species (Prunus spp): contribution of flow cytometry and molecular markers. 61
26782451 2015
14
Factors associated with increased caregivers' burden in several cognitive stages of Alzheimer's disease. 61
24650065 2014
15
Adenovirus structural protein IIIa is involved in the serotype specificity of viral DNA packaging. 61
21632753 2011
16
Role for the L1-52/55K protein in the serotype specificity of adenovirus DNA packaging. 61
18337584 2008
17
Human adenovirus type 35: nucleotide sequence and vector development. 61
14528318 2003
18
The complete nucleotide sequence, genome organization, and origin of human adenovirus type 11. 61
12726735 2003
19
Human adenovirus serotypes 4p and 11p are efficiently expressed in cell lines of neural tumour origin. 61
12029144 2002
20
The novel early region 3 protein E3/49K is specifically expressed by adenoviruses of subgenus D: implications for epidemic keratoconjunctivitis and adenovirus evolution. 61
12036321 2002
21
Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor. 61
11752156 2002
22
Role for the adenovirus IVa2 protein in packaging of viral DNA. 61
11581412 2001
23
Rapid detection and typing of oculopathogenic strain of subgenus D adenoviruses by fiber-based PCR and restriction enzyme analysis. 61
11481265 2001
24
A chimeric type 2 adenovirus vector with a type 17 fiber enhances gene transfer to human airway epithelia. 61
10482622 1999
25
Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C. 61
9971839 1999
26
Molecular characterization of hemagglutination domains on the fibers of subgenus D adenoviruses. 61
9499089 1998
27
Inhibition of rat dental caries by dextranase from a strain of Spicaria violacea. 61
978839 1976
28
Effect of dextranase on the extracellular polysaccharide synthesis of Streptococcus mutans; chemical and scanning electron microscopy studies. 61
1205620 1975

Variations for Alzheimer Disease 17

Expression for Alzheimer Disease 17

Search GEO for disease gene expression data for Alzheimer Disease 17.

Pathways for Alzheimer Disease 17

Pathways related to Alzheimer Disease 17 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.65 IL4 IL1RN CD68

GO Terms for Alzheimer Disease 17

Cellular components related to Alzheimer Disease 17 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 SPRY4 S100A9 KCNN4 KCNA3 KCNA2 IL1RN
2 glutamatergic synapse GO:0098978 9.62 PLAT KCNA3 DLG4 APOE
3 ruffle membrane GO:0032587 9.43 SPRY4 APC AIF1
4 juxtaparanode region of axon GO:0044224 9.16 KCNA2 DLG4
5 voltage-gated potassium channel complex GO:0008076 8.92 KCNN4 KCNA3 KCNA2 DLG4

Biological processes related to Alzheimer Disease 17 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory exploration behavior GO:0035641 9.16 DLG4 APOE
2 positive regulation of amyloid-beta clearance GO:1900223 8.96 IL4 APOE
3 AMPA glutamate receptor clustering GO:0097113 8.62 DLG4 APOE

Molecular functions related to Alzheimer Disease 17 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.33 KCNA3 KCNA2 HVCN1
2 potassium channel activity GO:0005267 9.13 KCNN4 KCNA3 KCNA2
3 outward rectifier potassium channel activity GO:0015271 8.62 KCNA3 KCNA2

Sources for Alzheimer Disease 17

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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