MCID: ALZ062
MIFTS: 28

Alzheimer Disease 19

Categories: Neuronal diseases, Genetic diseases, Mental diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 19

MalaCards integrated aliases for Alzheimer Disease 19:

Name: Alzheimer Disease 19 57 12 75 6 73
Ad19 57 12 75
Alzheimer Disease, Late Onset, Susceptibility to, Type 19 40
Alzheimer Disease 19, Late-Onset 57
Alzheimer Disease 19 Late Onset 12
Alzheimer Disease, Late Onset 73
Late-Onset Alzheimer Disease 75
Alzheimer's Disease 19 12

Classifications:



External Ids:

OMIM 57 615711
Disease Ontology 12 DOID:0110051
MeSH 44 D000544

Summaries for Alzheimer Disease 19

UniProtKB/Swiss-Prot : 75 Alzheimer disease 19: A late-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.

MalaCards based summary : Alzheimer Disease 19, also known as ad19, is related to alzheimer disease 2 and alzheimer disease. An important gene associated with Alzheimer Disease 19 is PLD3 (Phospholipase D Family Member 3). Affiliated tissues include testes, cortex and brain.

Disease Ontology : 12 An Alzheimer's disease that is characterized by associated variants of the gene PLD3.

Description from OMIM: 615711

Related Diseases for Alzheimer Disease 19

Graphical network of the top 20 diseases related to Alzheimer Disease 19:



Diseases related to Alzheimer Disease 19

Symptoms & Phenotypes for Alzheimer Disease 19

Clinical features from OMIM:

615711

Drugs & Therapeutics for Alzheimer Disease 19

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 19

Genetic Tests for Alzheimer Disease 19

Anatomical Context for Alzheimer Disease 19

MalaCards organs/tissues related to Alzheimer Disease 19:

41
Testes, Cortex, Brain

Publications for Alzheimer Disease 19

Articles related to Alzheimer Disease 19:

(show top 50) (show all 72)
# Title Authors Year
1
Association of lectin-like oxidized low density lipoprotein receptor 1 (<i>OLR1</i>) polymorphisms with late-onset Alzheimer disease in Han Chinese. ( 29951494 )
2018
2
Diagnostic Utility of the Shortened Version of the Wisconsin Card Sorting Test in Patients With Sporadic Late Onset Alzheimer Disease. ( 28859490 )
2017
3
Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4. ( 25542503 )
2016
4
The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort. ( 27076484 )
2016
5
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. ( 26827652 )
2016
6
Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease. ( 25414272 )
2015
7
Association of CLU and TLR2 gene polymorphisms with late-onset Alzheimer disease in a northwestern Iranian population. ( 26738351 )
2015
8
Early- and late-onset Alzheimer disease: Are they the same entity? ( 26546285 )
2015
9
Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4. ( 24644280 )
2014
10
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. ( 24670887 )
2014
11
Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. ( 24276092 )
2014
12
Age-Specific Incidence Rates for Dementia and Alzheimer Disease in NIA-LOAD/NCRAD and EFIGA Families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). ( 24425039 )
2014
13
KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers. ( 24349219 )
2013
14
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E I/4,and the risk of late-onset Alzheimer disease in African Americans. ( 23571587 )
2013
15
Association of GWAS top hits with late-onset Alzheimer disease in Korean population. ( 22975751 )
2013
16
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. ( 22881374 )
2012
17
Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. ( 23079898 )
2012
18
Microcephaly genes and risk of late-onset Alzheimer disease. ( 21297427 )
2011
19
PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility. ( 20523261 )
2010
20
Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. ( 20625269 )
2010
21
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. ( 20885792 )
2010
22
Association between NOS3 gene G894T polymorphism and late-onset Alzheimer disease in a sample from Iran. ( 20505439 )
2010
23
Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease. ( 20220325 )
2010
24
CALHM1 polymorphism is not associated with late-onset Alzheimer disease. ( 19472444 )
2009
25
[The expression of DJ-1 protein in proteomic analysis of late-onset Alzheimer disease]. ( 19576113 )
2009
26
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. ( 19442637 )
2009
27
Trospium and cognition in patients with late onset Alzheimer disease. ( 19657549 )
2009
28
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. ( 19118814 )
2009
29
Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. ( 19884614 )
2009
30
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. ( 18407551 )
2008
31
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. ( 18761660 )
2008
32
Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. ( 18340469 )
2008
33
No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. ( 17725684 )
2008
34
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease. ( 18525291 )
2008
35
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. ( 18236001 )
2008
36
Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. ( 17914065 )
2008
37
Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease. ( 17159347 )
2007
38
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. ( 17564960 )
2007
39
Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease. ( 17310123 )
2007
40
Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. ( 16876916 )
2007
41
The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. ( 17401152 )
2006
42
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ( 16385451 )
2006
43
Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. ( 16908746 )
2006
44
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease. ( 16401845 )
2006
45
On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease. ( 16914873 )
2006
46
Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease. ( 17001693 )
2006
47
Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease. ( 15882786 )
2005
48
Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele. ( 15805147 )
2005
49
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. ( 15714520 )
2005
50
Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease. ( 15034766 )
2004

Variations for Alzheimer Disease 19

Expression for Alzheimer Disease 19

Search GEO for disease gene expression data for Alzheimer Disease 19.

Pathways for Alzheimer Disease 19

GO Terms for Alzheimer Disease 19

Sources for Alzheimer Disease 19

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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