AD19
MCID: ALZ062
MIFTS: 32

Alzheimer Disease 19 (AD19)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 19

MalaCards integrated aliases for Alzheimer Disease 19:

Name: Alzheimer Disease 19 57 12 75 6 73
Ad19 57 12 75
Alzheimer Disease, Late Onset, Susceptibility to, Type 19 40
Alzheimer Disease 19, Late-Onset 57
Alzheimer Disease 19 Late Onset 12
Alzheimer Disease, Late Onset 73
Late-Onset Alzheimer Disease 75
Alzheimer's Disease 19 12

Classifications:



External Ids:

OMIM 57 615711
Disease Ontology 12 DOID:0110051
MeSH 44 D000544

Summaries for Alzheimer Disease 19

UniProtKB/Swiss-Prot : 75 Alzheimer disease 19: A late-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.

MalaCards based summary : Alzheimer Disease 19, also known as ad19, is related to alzheimer disease 2 and alzheimer disease. An important gene associated with Alzheimer Disease 19 is PLD3 (Phospholipase D Family Member 3). Affiliated tissues include brain, testes and cortex.

Disease Ontology : 12 An Alzheimer's disease that is characterized by associated variants of the gene PLD3.

Description from OMIM: 615711

Related Diseases for Alzheimer Disease 19

Graphical network of the top 20 diseases related to Alzheimer Disease 19:



Diseases related to Alzheimer Disease 19

Symptoms & Phenotypes for Alzheimer Disease 19

Clinical features from OMIM:

615711

Drugs & Therapeutics for Alzheimer Disease 19

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 19

Genetic Tests for Alzheimer Disease 19

Anatomical Context for Alzheimer Disease 19

MalaCards organs/tissues related to Alzheimer Disease 19:

41
Brain, Testes, Cortex

Publications for Alzheimer Disease 19

Articles related to Alzheimer Disease 19:

(show top 50) (show all 80)
# Title Authors Year
1
Association of lectin-like oxidized low density lipoprotein receptor 1 (<i>OLR1</i>) polymorphisms with late-onset Alzheimer disease in Han Chinese. ( 29951494 )
2018
2
The p.R47H Variant of TREM2 Gene is Associated With Late-onset Alzheimer Disease in Colombian Population. ( 30222607 )
2018
3
Caregivers' Perspectives of Quality of Life of People With Young- and Late-Onset Alzheimer Disease. ( 29658428 )
2018
4
Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. ( 29670507 )
2018
5
Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. ( 29044639 )
2018
6
Diagnostic Utility of the Shortened Version of the Wisconsin Card Sorting Test in Patients With Sporadic Late Onset Alzheimer Disease. ( 28859490 )
2017
7
Genetic Ancestry and Susceptibility to Late-Onset Alzheimer Disease (LOAD) in the Admixed Colombian Population. ( 28369008 )
2017
8
Late-Onset Alzheimer Disease. ( 28410660 )
2017
9
Early-versus Late-Onset Alzheimer Disease: Long-Term Functional Outcomes, Nursing Home Placement, and Risk Factors for Rate of Progression. ( 28626471 )
2017
10
Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4. ( 25542503 )
2016
11
The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort. ( 27076484 )
2016
12
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. ( 26827652 )
2016
13
SORL1 mutations in early- and late-onset Alzheimer disease. ( 27822510 )
2016
14
Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease. ( 27066578 )
2016
15
Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease. ( 25414272 )
2015
16
Association of CLU and TLR2 gene polymorphisms with late-onset Alzheimer disease in a northwestern Iranian population. ( 26738351 )
2015
17
Early- and late-onset Alzheimer disease: Are they the same entity? ( 26546285 )
2015
18
Late-onset Alzheimer disease risk variants mark brain regulatory loci. ( 27066552 )
2015
19
Contrasts Between Patients With Lewy Body Dementia Syndromes and APOE-ε3/ε3 Patients With Late-onset Alzheimer Disease Dementia. ( 26280289 )
2015
20
Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4. ( 24644280 )
2014
21
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. ( 24670887 )
2014
22
Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. ( 24276092 )
2014
23
Age-Specific Incidence Rates for Dementia and Alzheimer Disease in NIA-LOAD/NCRAD and EFIGA Families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). ( 24425039 )
2014
24
KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers. ( 24349219 )
2013
25
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E I/4,and the risk of late-onset Alzheimer disease in African Americans. ( 23571587 )
2013
26
Association of GWAS top hits with late-onset Alzheimer disease in Korean population. ( 22975751 )
2013
27
Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. ( 23079898 )
2012
28
Microcephaly genes and risk of late-onset Alzheimer disease. ( 21297427 )
2011
29
PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility. ( 20523261 )
2010
30
Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. ( 20625269 )
2010
31
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. ( 20885792 )
2010
32
Association between NOS3 gene G894T polymorphism and late-onset Alzheimer disease in a sample from Iran. ( 20505439 )
2010
33
Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease. ( 20220325 )
2010
34
CALHM1 polymorphism is not associated with late-onset Alzheimer disease. ( 19472444 )
2009
35
[The expression of DJ-1 protein in proteomic analysis of late-onset Alzheimer disease]. ( 19576113 )
2009
36
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. ( 19442637 )
2009
37
Trospium and cognition in patients with late onset Alzheimer disease. ( 19657549 )
2009
38
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. ( 19118814 )
2009
39
Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. ( 19884614 )
2009
40
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. ( 18407551 )
2008
41
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. ( 18761660 )
2008
42
Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. ( 18340469 )
2008
43
No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. ( 17725684 )
2008
44
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease. ( 18525291 )
2008
45
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. ( 18236001 )
2008
46
Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease. ( 17159347 )
2007
47
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. ( 17564960 )
2007
48
Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease. ( 17310123 )
2007
49
Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. ( 16876916 )
2007
50
The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. ( 17401152 )
2006

Variations for Alzheimer Disease 19

ClinVar genetic disease variations for Alzheimer Disease 19:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PLD3 NM_012268.3(PLD3): c.694G> A (p.Val232Met) single nucleotide variant Uncertain significance rs145999145 GRCh38 Chromosome 19, 40371688: 40371688
2 PLD3 NM_012268.3(PLD3): c.694G> A (p.Val232Met) single nucleotide variant Uncertain significance rs145999145 GRCh37 Chromosome 19, 40877595: 40877595

Expression for Alzheimer Disease 19

Search GEO for disease gene expression data for Alzheimer Disease 19.

Pathways for Alzheimer Disease 19

GO Terms for Alzheimer Disease 19

Sources for Alzheimer Disease 19

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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