AD5
MCID: ALZ050
MIFTS: 37

Alzheimer Disease 5 (AD5)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 5

MalaCards integrated aliases for Alzheimer Disease 5:

Name: Alzheimer Disease 5 57 12 73
Ad5 57 12
Alzheimer Disease, Familial, Type 5 13
Alzheimer Disease, Familial, 5 57
Alzheimer Disease, Familial 5 12
Alzheimer's Disease 5 12
Alzheimer Disease-5 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
alzheimer disease 5:
Onset and clinical course late onset
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 602096
Disease Ontology 12 DOID:0110037
ICD10 33 G30
MedGen 42 C1865868
SNOMED-CT via HPO 69 263681008 230267005 26929004
UMLS 73 C1865868

Summaries for Alzheimer Disease 5

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 12p11.23-q13.12.

MalaCards based summary : Alzheimer Disease 5, also known as ad5, is related to alzheimer disease and perrault syndrome 1. An important gene associated with Alzheimer Disease 5 is AD5 (Alzheimer Disease 5). The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and lung, and related phenotype is alzheimer disease.

Description from OMIM: 602096

Related Diseases for Alzheimer Disease 5

Graphical network of the top 20 diseases related to Alzheimer Disease 5:



Diseases related to Alzheimer Disease 5

Symptoms & Phenotypes for Alzheimer Disease 5

Symptoms via clinical synopsis from OMIM:

57
Neuro:
late-onset form of familial alzheimer disease (ad)

Misc:
onset at least 60 years


Clinical features from OMIM:

602096

Human phenotypes related to Alzheimer Disease 5:

32
# Description HPO Frequency HPO Source Accession
1 alzheimer disease 32 HP:0002511

Drugs & Therapeutics for Alzheimer Disease 5

Drugs for Alzheimer Disease 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
2 tannic acid Approved Phase 3
3 Mitogens Phase 2, Phase 3,Phase 3,Phase 1
4
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
5
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
6
Cisplatin Approved Phase 2,Phase 1 15663-27-1 2767 441203 84093
7
Nitroprusside Approved, Investigational Phase 1, Phase 2 15078-28-1 11963622
8
Flucytosine Approved, Investigational Phase 2,Phase 1 2022-85-7 3366
9
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
10
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
11
Maraviroc Approved, Investigational Phase 2 376348-65-1 3002977
12
Coal tar Approved Phase 2 8007-45-2
13
Capecitabine Approved, Investigational Phase 1, Phase 2,Phase 2 154361-50-9 60953
14
Cetuximab Approved Phase 1, Phase 2,Phase 2 205923-56-4 56842117 2333
15
Cyclophosphamide Approved, Investigational Phase 1, Phase 2,Phase 2 6055-19-2, 50-18-0 2907
16
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
17
leucovorin Approved Phase 1, Phase 2,Phase 2 58-05-9 6006 143
18
Fluorouracil Approved Phase 1, Phase 2,Phase 2 51-21-8 3385
19
Oxaliplatin Approved, Investigational Phase 1, Phase 2,Phase 2 61825-94-3 43805 6857599 5310940 9887054
20
Trastuzumab Approved, Investigational Phase 1, Phase 2 180288-69-1 9903
21
Levoleucovorin Approved, Investigational Phase 1, Phase 2,Phase 2 68538-85-2
22
Gemcitabine Approved Phase 2 95058-81-4 60750
23
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
24
Fulvestrant Approved, Investigational Phase 1, Phase 2,Phase 2 129453-61-8 17756771 104741
25
Nivolumab Approved Phase 1, Phase 2,Phase 2 946414-94-4
26
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
27
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
28
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2,Phase 2 56-86-0 33032
29
Doxil Approved June 1999 Phase 2,Phase 1 31703
30 Vaccines Phase 2,Phase 1
31 Cyclooxygenase 2 Inhibitors Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Analgesics Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Anti-Inflammatory Agents Phase 2
36 Cyclooxygenase Inhibitors Phase 2
37 Antirheumatic Agents Phase 2,Phase 1
38 Analgesics, Non-Narcotic Phase 2
39 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
40 Angiogenesis Modulating Agents Phase 2,Phase 1
41 Endostatins Phase 2 71581480
42 Angiogenesis Inhibitors Phase 2,Phase 1
43 Albumin-Bound Paclitaxel Phase 2,Phase 1
44 Antimitotic Agents Phase 2,Phase 1
45 Immunologic Factors Phase 1, Phase 2,Phase 2
46 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
47 Cola Phase 1, Phase 2
48 Antibiotics, Antitubercular Phase 2,Phase 1
49 Anti-Bacterial Agents Phase 2,Phase 1
50 Topoisomerase Inhibitors Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Intracoronary Ad5FGF-4 in Patients With Stable Angina Unknown status NCT00185263 Phase 2, Phase 3
2 Angiogenesis in Women With Angina Pectoris Who Are Not Candidates for Revascularization Unknown status NCT00438867 Phase 3
3 Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia Not yet recruiting NCT02928094 Phase 3
4 Efficacy and Safety of Intracoronary Ad5FGF-4 in Patients With Stable Angina (AGENT-3) Completed NCT00346437 Phase 2, Phase 3
5 Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease Terminated NCT01550614 Phase 3
6 AC6 Gene Transfer in Patients With Reduced Left Ventricular Ejection Fraction Heart Failure Not yet recruiting NCT03360448 Phase 3 Ad5.hAC6;Placebo
7 A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis Recruiting NCT03435081 Phase 3 Baricitinib;Placebo
8 A Study of Baricitinib (LY3009104) in Participants With Moderate to Severe Atopic Dermatitis Enrolling by invitation NCT03559270 Phase 3 Baricitinib
9 Vaccine Therapy and Celecoxib in Treating Patients With Metastatic Nasopharyngeal Cancer Unknown status NCT00589186 Phase 2 celecoxib
10 Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer Unknown status NCT00003257 Phase 2
11 Safety and Efficacy of DC-CIK in Patients With Advanced Non-Small-Cell Lung Cancer With Bone Metastases Unknown status NCT02688686 Phase 1, Phase 2
12 Trial of E10A in Head and Neck Cancer Unknown status NCT00634595 Phase 2 E10A;Cisplatin;Paclitaxel
13 Active Immunotherapy CEA Vaccine in Patients With Malignancies Expressing CEA Completed NCT01147965 Phase 1, Phase 2
14 Use of Recombinant Adenovirus Therapy to Treat Localized Prostate Cancer Recruiting NCT01931046 Phase 1, Phase 2 Ad5-SGE-REIC/Dkk3
15 Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients Completed NCT00080106 Phase 2
16 QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer Active, not recruiting NCT03127098 Phase 1, Phase 2
17 Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx Completed NCT00064103 Phase 1, Phase 2
18 AC6 Gene Transfer for CHF Completed NCT00787059 Phase 1, Phase 2 Ad5.hAC6;Sucrose (3%)
19 Investigation of V520 in a HIV Vaccine Dose Refinement Study (V520-027)(TERMINATED) Terminated NCT00350623 Phase 2
20 A Clinical Trial to Evaluate the Recombinant Human Type5 Adenovirus Vector Based Ebola Virus Disease Vaccine Completed NCT02575456 Phase 2
21 Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities Completed NCT00493051 Phase 2
22 Randomized Trial of Suicide Gene Therapy and Prostate Cancer Completed NCT00583492 Phase 2
23 S0011, Gene Therapy & Surgery Followed by Chemo & RT in Newly Diagnosed Cancer of the Mouth or Throat Terminated NCT00017173 Phase 2 cisplatin
24 Chemotherapy Combined With Gene Therapy in Treating Patients Who Have Stage III or Stage IV Breast Cancer Completed NCT00044993 Phase 2 docetaxel;doxorubicin hydrochloride
25 Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss Recruiting NCT02132130 Phase 1, Phase 2 CGF166
26 Study of Recombinant Adenovirus AdVince in Patients With Neuroendocrine Tumors; Safety and Efficacy Recruiting NCT02749331 Phase 1, Phase 2 AdVince
27 Investigation of V520 in an HIV Vaccine Proof-of-Concept Study (V520-023) Terminated NCT00095576 Phase 2 Comparator: placebo
28 Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir Completed NCT00976404 Phase 2 ART intensification (raltegravir);ART intensification (maraviroc)
29 Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer Completed NCT01687244 Phase 2 INSTILADRIN
30 Evaluate Efficacy, Immunological Response of Intratumoral/Intralesional Oncolytic Virus (OBP-301) in Metastatic Melanoma Patients Recruiting NCT03190824 Phase 2 OBP-301
31 Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage Small Cell Lung Cancer Terminated NCT00776295 Phase 2
32 A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine Completed NCT02918006 Phase 2
33 A Multicenter Randomized Double-blind Placebo-controlled Pilot Study of Safety, Pharmacodynamics and Efficacy of Different Treatments of Immunotherapeutic Drug Mobilan (M-VM3) in Patients With Diagnosed Prostate Cancer Active, not recruiting NCT02844699 Phase 1, Phase 2 Mobilan (M-VM3);Placebo
34 Safety and Efficacy of a Three-Dose Regimen of an Adenoviral HIV Vaccine (MRKAd5 HIV-1 Gag/Pol/Nef) in HIV Uninfected South African Adults Completed NCT00413725 Phase 2
35 A Double-blind Randomized Placebo-controlled Study of Safety and Immunogenicity of GamEvac-Lyo Completed NCT03333538 Phase 1, Phase 2
36 QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed Recruiting NCT03387111 Phase 1, Phase 2 Aldoxorubicin HCl;Avelumab;bevacizumab;Capecitabine;Cetuximab;Cisplatin;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel;Necitumumab
37 QUILT-3.080: NANT Pancreatic Cancer Vaccine Recruiting NCT03586869 Phase 1, Phase 2 Aldoxorubicin HCl;Capecitabine;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel;Oxaliplatin
38 QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine Recruiting NCT03563157 Phase 1, Phase 2 Avelumab;Capecitabine;Cetuximab;Cyclophosphamide;5-Fluorouracil;Leucovorin;Nab-paclitaxel;Oxaliplatin;Regorafenib
39 QUILT-3.088: NANT Pancreatic Cancer Vaccine Not yet recruiting NCT03563144 Phase 2 Gemcitabine;Nab-paclitaxel;Aldoxorubicin HCl;Avelumab;Bevacizumab;Capecitabine;Cyclophosphamide;5-Fluorouracil;Leucovorin;Oxaliplatin
40 QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine Recruiting NCT03563170 Phase 1, Phase 2 Capecitabine;Cyclophosphamide;5-Fluorouracil;Leucovorin;nab-Paclitaxel;Sorafenib;Cetuximab
41 QUILT-3.067: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With TNBC Who Have Progressed on or After Standard-of-care Therapy. Recruiting NCT03387085 Phase 1, Phase 2 Aldoxorubicin HCl;Capecitabine;Cisplatin;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel
42 QUILT-3.048: NANT Urothelial Cancer Vaccine: Combination Immunotherapy in Subjects With Urothelial Cancer Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03197571 Phase 1, Phase 2 capecitabine;cisplatin;cyclophosphamide;5Fluorouracil (5-FU);fulvestrant;leucovorin;nab-paclitaxel;Lovaza
43 QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC Not yet recruiting NCT03169777 Phase 1, Phase 2 capecitabine;Cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab paclitaxel;Lovaza;oxaliplatin
44 QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03169764 Phase 1, Phase 2 Capecitabine;Cisplatin;cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab-paclitaxel;Lovaza
45 QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors Not yet recruiting NCT03169738 Phase 1, Phase 2 Capecitabine;Cisplatin;cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab paclitaxel;Lovaza;Oxaliplatin
46 QUILT-3.057: NANT Neoadjuvant Triple- Negative Breast Cancer (TNBC) Vaccine Not yet recruiting NCT03554109 Phase 2 Leucovorin;5-Fluorouracil;Aldoxorubicin HCl;nab-Paclitaxel;Avelumab;Cyclophosphamide;Doxorubicin HCL;paclitaxel
47 QUILT-3.046: NANT Melanoma Vaccine: Combination Immunotherapy in Subjects With Melanoma Who Have Progressed On or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03167177 Phase 1, Phase 2 Capecitabine;Cisplatin;Cyclophosphamide;5-fluorouracil;Leucovorin;nab-paclitaxel;omega-3-acid ethyl esters
48 QUILT-3.051: NANT Ovarian Cancer Vaccine: Combination Immunotherapy in Subjects With Epithelial Ovarian Cancer Who Have Progressed on or After Standard-of-care (SoC) Therapy Not yet recruiting NCT03197584 Phase 1, Phase 2 Capecitabine;Cyclophosphamide;5-fluorouracil;Fulvestrant;Leucovorin;Paclitaxel;omega-3 acid ethyl esters;Oxaliplatin
49 NANT Triple Negative Breast Cancer (TNBC) Vaccine: Combination Immunotherapy in Subjects With TNBC Who Have Progressed on or After Anthracycline-based Chemotherapy Not yet recruiting NCT03175666 Phase 1, Phase 2 capecitabine;cisplatin;cyclophosphamide;5-Fluorouracil;Leucovorin;nab-paclitaxel;Lovaza
50 QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer Not yet recruiting NCT03574649 Phase 2 Nab-paclitaxel;Cisplatin;5Fluorouracil;Cyclophosphamide;Aldoxorubicin;Avelumab;ALT-803;Docetaxel;carboplatin

Search NIH Clinical Center for Alzheimer Disease 5

Genetic Tests for Alzheimer Disease 5

Anatomical Context for Alzheimer Disease 5

MalaCards organs/tissues related to Alzheimer Disease 5:

41
T Cells, Brain, Lung, Breast, Liver, Bone, Heart

Publications for Alzheimer Disease 5

Articles related to Alzheimer Disease 5:

(show top 50) (show all 163)
# Title Authors Year
1
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells. ( 29367266 )
2018
2
Ag85A-specific CD4+ T cell lines derived after boosting BCG-vaccinated cattle with Ad5-85A possess both mycobacterial growth inhibition and anti-inflammatory properties. ( 29655632 )
2018
3
Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection. ( 29680370 )
2018
4
Long-term toxicity, pharmacokinetics and immune effects of a recombinant adenovirus vaccine expressing human papillomavirus 16 E6 and E7 proteins (HPV16 E6E7-Ad5 Vac) in primates. ( 29887967 )
2018
5
Establishing China's national standard for virus titer of the recombinant adenovirus type-5 vector-based Ebola vaccine (Ad5-EBOV). ( 30381976 )
2018
6
Active and separate secretion of fiber and penton base during the early phase of Ad2 or Ad5 infection. ( 28264780 )
2017
7
Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia. ( 28152326 )
2017
8
Effects of metal ions on the structure and activity of a human anti-cyclin D1 single-chain variable fragment AD5. ( 28627625 )
2017
9
Open-label phase I clinical trial of Ad5-EBOV in Africans in China. ( 28708962 )
2017
10
A novel fiber chimeric conditionally replicative adenovirus-Ad5/F35 for tumor therapy. ( 29144842 )
2017
11
Combination of Adt-O1Manisa and Ad5-boIFNλ3 induces early protective immunity against foot-and-mouth disease in cattle. ( 27743960 )
2016
12
Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors. ( 26934960 )
2016
13
In vitro CRISPR-Cas9-mediated efficient Ad5 vector modification. ( 27125457 )
2016
14
A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine. ( 27128437 )
2016
15
Efficacy of CD46-targeting chimeric Ad5/35 adenoviral gene therapy for colorectal cancers. ( 27203670 )
2016
16
Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity. ( 27302248 )
2016
17
A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens. ( 27574299 )
2016
18
Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions. ( 27682509 )
2016
19
Correction: Preclinical Assessment of FHIT Gene Replacement Therapy in Human Leukemia Using a Chimeric Adenovirus, Ad5/F35. ( 27856602 )
2016
20
Potent antitumor activity of the Ad5/11 chimeric oncolytic adenovirus combined with interleukin-24 for acute myeloid leukemia via induction of apoptosis. ( 25339149 )
2015
21
Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy. ( 25714011 )
2015
22
Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer. ( 25956394 )
2015
23
Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation. ( 26052525 )
2015
24
Overexpression of Ad5 precursor terminal protein accelerates recombinant adenovirus packaging and amplification in HEK-293 packaging cells. ( 24784448 )
2014
25
Ad5/48 hexon oncolytic virus expressing sTGFβRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases. ( 24791939 )
2014
26
Hexon hypervariable region-modified adenovirus type 5 (Ad5) vectors display reduced hepatotoxicity but induce T lymphocyte phenotypes similar to Ad5 vectors. ( 24943382 )
2014
27
Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef vaccine induced immune responses. ( 25090110 )
2014
28
CpG-mediated modulation of MDSC contributes to the efficacy of Ad5-TRAIL therapy against renal cell carcinoma. ( 25143233 )
2014
29
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals. ( 25197078 )
2014
30
Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration. ( 25546428 )
2014
31
Gene therapy for cancer through adenovirus vector‑mediated expression of the Ad5 early region gene 1A based on loss of IGF2 imprinting. ( 23900345 )
2013
32
Chimeric adenoviral vector Ad5F35L containing the Ad5 natural long-shaft exhibits efficient gene transfer into human T lymphocytes. ( 23933078 )
2013
33
Expression and purification of a human anti-cyclin D1 single-chain variable fragment antibody AD5 and its characterization. ( 24127128 )
2013
34
The effect of artificial lipid envelopment of Adenovirus 5 (Ad5) on liver de-targeting and hepatotoxicity. ( 23146432 )
2013
35
Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors. ( 23152535 )
2013
36
The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. ( 23403990 )
2013
37
Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancer. ( 23509821 )
2013
38
Combined use of adenoviral vector Ad5/F35-mediated APE1 siRNA enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in hepatoma cells in vitro and in vivo. ( 23563597 )
2013
39
A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer. ( 23756180 )
2013
40
Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors. ( 21630267 )
2012
41
HPV-16 E1, E2 and E6 each complement the Ad5 helper gene set, increasing rAAV2 and wt AAV2 production. ( 21850053 )
2012
42
Syrian hamster tumor model to study oncolytic Ad5-based vectors. ( 21948468 )
2012
43
A fiber chimeric CRAd vector Ad5/11-D24 double-armed with TRAIL and arresten for enhanced glioblastoma therapy. ( 22136065 )
2012
44
Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine. ( 22156519 )
2012
45
Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine. ( 22201684 )
2012
46
Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells. ( 22210093 )
2012
47
An optimized SIV DNA vaccine can serve as a boost for Ad5 and provide partial protection from a high-dose SIVmac251 challenge. ( 22406458 )
2012
48
Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. ( 22496772 )
2012
49
Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination. ( 22496775 )
2012
50
A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancer. ( 22510347 )
2012

Variations for Alzheimer Disease 5

Expression for Alzheimer Disease 5

Search GEO for disease gene expression data for Alzheimer Disease 5.

Pathways for Alzheimer Disease 5

GO Terms for Alzheimer Disease 5

Sources for Alzheimer Disease 5

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