MCID: ALZ050
MIFTS: 37

Alzheimer Disease 5

Categories: Neuronal diseases, Rare diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Alzheimer Disease 5

MalaCards integrated aliases for Alzheimer Disease 5:

Name: Alzheimer Disease 5 57 12 73
Ad5 57 12
Alzheimer Disease, Familial, Type 5 13
Alzheimer Disease, Familial, 5 57
Alzheimer Disease, Familial 5 12
Alzheimer's Disease 5 12
Alzheimer Disease-5 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
alzheimer disease 5:
Inheritance autosomal dominant inheritance
Onset and clinical course late onset


Classifications:



External Ids:

OMIM 57 602096
Disease Ontology 12 DOID:0110037
ICD10 33 G30
MedGen 42 C1865868
SNOMED-CT via HPO 69 263681008 230267005 26929004
UMLS 73 C1865868

Summaries for Alzheimer Disease 5

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 12p11.23-q13.12.

MalaCards based summary : Alzheimer Disease 5, also known as ad5, is related to alzheimer disease and glioma. An important gene associated with Alzheimer Disease 5 is AD5 (Alzheimer Disease 5), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Mitogens and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and prostate, and related phenotype is alzheimer disease.

Description from OMIM: 602096

Related Diseases for Alzheimer Disease 5

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 6
Alzheimer Disease 7 Alzheimer Disease 4
Alzheimer Disease 8 Alzheimer Disease 3
Alzheimer Disease 9 Alzheimer Disease 10
Alzheimer Disease 11 Alzheimer Disease 12
Alzheimer Disease 13 Alzheimer Disease 14
Alzheimer Disease 15 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Early-Onset Familial Alzheimer Disease Alzheimer Disease Type 1
Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 11.2
2 glioma 10.0
3 lung cancer susceptibility 3 9.9
4 malignant glioma 9.9
5 adenocarcinoma 9.9
6 psychosexual disorder 9.8 HTR2A SLC6A4
7 alcoholic psychosis 9.8 HTR2A SLC6A4
8 dysthymic disorder 9.8 HTR2A SLC6A4
9 periodic limb movement disorder 9.8 HTR2A SLC6A4
10 pathological gambling 9.8 HTR2A SLC6A4
11 bruxism 9.8 HTR2A SLC6A4
12 fibromyalgia 9.8 HTR2A SLC6A4
13 paranoid schizophrenia 9.8 HTR2A SLC6A4
14 early-onset schizophrenia 9.8 HTR2A SLC6A4
15 borderline personality disorder 9.8 HTR2A SLC6A4
16 serotonin syndrome 9.8 HTR2A SLC6A4
17 bipolar i disorder 9.8 HTR2A SLC6A4
18 mental depression 9.8 HTR2A SLC6A4
19 generalized anxiety disorder 9.8 HTR2A SLC6A4
20 personality disorder 9.8 HTR2A SLC6A4
21 bulimia nervosa 9.7 HTR2A SLC6A4
22 post-traumatic stress disorder 9.7 HTR2A SLC6A4
23 schizoaffective disorder 9.7 HTR2A SLC6A4
24 disease of mental health 9.7 HTR2A SLC6A4
25 depression 9.7 HTR2A SLC6A4
26 mood disorder 9.7 HTR2A SLC6A4
27 psychotic disorder 9.7 HTR2A SLC6A4
28 anorexia nervosa 9.7 HTR2A SLC6A4
29 obsessive-compulsive disorder 9.6 HTR2A SLC6A4
30 anxiety 9.6 HTR2A SLC6A4
31 panic disorder 9.6 HTR2A SLC6A4
32 migraine with or without aura 1 9.6 HTR2A SLC6A4
33 autism spectrum disorder 9.6 HTR2A SLC6A4
34 sudden infant death syndrome 9.5 HTR2A SLC6A4
35 major depressive disorder 9.5 HTR2A SLC6A4
36 alcohol dependence 9.4 HTR2A SLC6A4
37 attention deficit-hyperactivity disorder 9.3 HTR2A SLC6A4
38 parkinson disease, late-onset 9.2 HTR2A SLC6A4
39 bipolar disorder 9.0 HTR2A SLC6A4

Graphical network of the top 20 diseases related to Alzheimer Disease 5:



Diseases related to Alzheimer Disease 5

Symptoms & Phenotypes for Alzheimer Disease 5

Symptoms via clinical synopsis from OMIM:

57
Neuro:
late-onset form of familial alzheimer disease (ad)

Misc:
onset at least 60 years


Clinical features from OMIM:

602096

Human phenotypes related to Alzheimer Disease 5:

32
# Description HPO Frequency HPO Source Accession
1 alzheimer disease 32 HP:0002511

Drugs & Therapeutics for Alzheimer Disease 5

Drugs for Alzheimer Disease 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 2, Phase 3,Phase 3,Phase 1
2
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
3
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
5
Nitroprusside Approved, Investigational Phase 1, Phase 2 15078-28-1 11963622
6
Flucytosine Approved, Investigational Phase 2,Phase 1 2022-85-7 3366
7
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
8
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
9
Maraviroc Approved, Investigational Phase 2 376348-65-1 3002977
10
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
11
Capecitabine Approved, Investigational Phase 1, Phase 2,Phase 2 154361-50-9 60953
12
Cetuximab Approved Phase 1, Phase 2,Phase 2 205923-56-4 56842117 2333
13
Cyclophosphamide Approved, Investigational Phase 1, Phase 2,Phase 2 50-18-0, 6055-19-2 2907
14
Fluorouracil Approved Phase 1, Phase 2,Phase 2 51-21-8 3385
15
Oxaliplatin Approved, Investigational Phase 1, Phase 2,Phase 2 61825-94-3 5310940 9887054 43805 6857599
16
Fulvestrant Approved, Investigational Phase 1, Phase 2,Phase 2 129453-61-8 104741 17756771
17
nivolumab Approved Phase 1, Phase 2,Phase 2 946414-94-4
18
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
19
Coal tar Approved Phase 2 8007-45-2
20
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2,Phase 2 56-86-0 33032
21
leucovorin Approved, Nutraceutical Phase 1, Phase 2,Phase 2 58-05-9 143 6006
22
Doxil Approved June 1999 Phase 2,Phase 1 31703
23 Analgesics Phase 2
24 Analgesics, Non-Narcotic Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2
27 Antirheumatic Agents Phase 2,Phase 1
28 Cyclooxygenase 2 Inhibitors Phase 2
29 Cyclooxygenase Inhibitors Phase 2
30 Peripheral Nervous System Agents Phase 2
31 Vaccines Phase 2,Phase 1
32 Albumin-Bound Paclitaxel Phase 2,Phase 1
33 Angiogenesis Inhibitors Phase 2,Phase 1
34 Angiogenesis Modulating Agents Phase 2,Phase 1
35 Antimitotic Agents Phase 2,Phase 1
36 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
37 Endostatins Phase 2 71581480
38 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
39 Disinfectants Phase 2
40 Anti-Bacterial Agents Phase 2,Phase 1
41 Antibiotics, Antitubercular Phase 2,Phase 1
42 Topoisomerase Inhibitors Phase 2,Phase 1
43 Anti-HIV Agents Phase 2
44 Anti-Infective Agents Phase 2,Phase 1
45 Anti-Retroviral Agents Phase 2
46 Antiviral Agents Phase 2,Phase 1
47 HIV Integrase Inhibitors Phase 2
48 Integrase Inhibitors Phase 2
49 Raltegravir Potassium Phase 2
50 Interferon-alpha Phase 2

Interventional clinical trials:

(show top 50) (show all 94)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Intracoronary Ad5FGF-4 in Patients With Stable Angina Unknown status NCT00185263 Phase 2, Phase 3
2 Angiogenesis in Women With Angina Pectoris Who Are Not Candidates for Revascularization Unknown status NCT00438867 Phase 3
3 Efficacy and Safety of Intracoronary Ad5FGF-4 in Patients With Stable Angina (AGENT-3) Completed NCT00346437 Phase 2, Phase 3
4 A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis Recruiting NCT03435081 Phase 3 Baricitinib;Placebo
5 A Study of Baricitinib (LY3009104) in Participants With Moderate to Severe Atopic Dermatitis Enrolling by invitation NCT03559270 Phase 3 Baricitinib
6 Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia Not yet recruiting NCT02928094 Phase 3
7 AC6 Gene Transfer in Patients With Reduced Left Ventricular Ejection Fraction Heart Failure Not yet recruiting NCT03360448 Phase 3 Ad5.hAC6;Placebo
8 Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease Terminated NCT01550614 Phase 3
9 Vaccine Therapy and Celecoxib in Treating Patients With Metastatic Nasopharyngeal Cancer Unknown status NCT00589186 Phase 2 celecoxib
10 Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer Unknown status NCT00003257 Phase 2
11 Safety and Efficacy of DC-CIK in Patients With Advanced Non-Small-Cell Lung Cancer With Bone Metastases Unknown status NCT02688686 Phase 1, Phase 2
12 Trial of E10A in Head and Neck Cancer Unknown status NCT00634595 Phase 2 E10A;Cisplatin;Paclitaxel
13 Active Immunotherapy CEA Vaccine in Patients With Malignancies Expressing CEA Completed NCT01147965 Phase 1, Phase 2
14 Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients Completed NCT00080106 Phase 2
15 Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx Completed NCT00064103 Phase 1, Phase 2
16 AC6 Gene Transfer for CHF Completed NCT00787059 Phase 1, Phase 2 Ad5.hAC6;Sucrose (3%)
17 A Clinical Trial to Evaluate the Recombinant Human Type5 Adenovirus Vector Based Ebola Virus Disease Vaccine Completed NCT02575456 Phase 2
18 Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities Completed NCT00493051 Phase 2
19 Randomized Trial of Suicide Gene Therapy and Prostate Cancer Completed NCT00583492 Phase 2
20 Chemotherapy Combined With Gene Therapy in Treating Patients Who Have Stage III or Stage IV Breast Cancer Completed NCT00044993 Phase 2 docetaxel;doxorubicin hydrochloride
21 Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir Completed NCT00976404 Phase 2 ART intensification (raltegravir);ART intensification (maraviroc)
22 Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer Completed NCT01687244 Phase 2 INSTILADRIN
23 Safety and Efficacy of a Three-Dose Regimen of an Adenoviral HIV Vaccine (MRKAd5 HIV-1 Gag/Pol/Nef) in HIV Uninfected South African Adults Completed NCT00413725 Phase 2
24 Use of Recombinant Adenovirus Therapy to Treat Localized Prostate Cancer Recruiting NCT01931046 Phase 1, Phase 2 Ad5-SGE-REIC/Dkk3
25 Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss Recruiting NCT02132130 Phase 1, Phase 2 CGF166
26 Study of Recombinant Adenovirus AdVince in Patients With Neuroendocrine Tumors; Safety and Efficacy Recruiting NCT02749331 Phase 1, Phase 2 AdVince
27 Evaluate Efficacy, Immunological Response of Intratumoral/Intralesional Oncolytic Virus (OBP-301) in Metastatic Melanoma Patients Recruiting NCT03190824 Phase 2 OBP-301
28 A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine Recruiting NCT02918006 Phase 2
29 A Double-blind Randomized Placebo-controlled Study of Safety and Immunogenicity of GamEvac-Lyo Recruiting NCT03333538 Phase 1, Phase 2
30 QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine Recruiting NCT03563157 Phase 1, Phase 2 Avelumab;Capecitabine;Cetuximab;Cyclophosphamide;5-Fluorouracil;Leucovorin;Nab-paclitaxel;Oxaliplatin;Regorafenib;Trastuzumab
31 QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With SCC Who Have Progressed on or After Platinum-based Chemotherapy and Anti-programmed Cell Death Protein 1 (PD-1)/Programmed Death-ligand Recruiting NCT03387111 Phase 1, Phase 2 Aldoxorubicin HCl;Capecitabine;Cetuximab;Cisplatin;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel;Necitumumab
32 QUILT-3.067: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With TNBC Who Have Progressed on or After Standard-of-care Therapy. Recruiting NCT03387085 Phase 1, Phase 2 Aldoxorubicin HCl;Capecitabine;Cisplatin;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel
33 QUILT-3.070: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy Recruiting NCT03387098 Phase 1, Phase 2 Aldoxorubicin HCl;Capecitabine;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel;lovaza;Oxaliplatin
34 QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer Active, not recruiting NCT03127098 Phase 1, Phase 2
35 A Multicenter Randomized Double-blind Placebo-controlled Pilot Study of Safety, Pharmacodynamics and Efficacy of Different Treatments of Immunotherapeutic Drug Mobilan (M-VM3) in Patients With Diagnosed Prostate Cancer Active, not recruiting NCT02844699 Phase 1, Phase 2 Mobilan (M-VM3);Placebo
36 QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy Active, not recruiting NCT03329248 Phase 1, Phase 2 Capecitabine;Cyclophosphamide;Fluorouracil;Leucovorin;nab-Paclitaxel;lovaza;Oxaliplatin
37 QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy Active, not recruiting NCT03136406 Phase 1, Phase 2 Cyclophosphamide;Oxaliplatin;Capecitabine;5-Fluorouracil;Leucovorin;nab-paclitaxel
38 QUILT-3.088: NANT Pancreatic Cancer Vaccine Not yet recruiting NCT03563144 Phase 2 Gemcitabine;Nab-paclitaxel;Aldoxorubicin HCl;Avelumab;Bevacizumab;Capecitabine;Cyclophosphamide;5-Fluorouracil;Leucovorin;Oxaliplatin
39 QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine Not yet recruiting NCT03563170 Phase 1, Phase 2 Capecitabine;Cyclophosphamide;5-Fluorouracil;Leucovorin;nab-Paclitaxel;Sorafenib;Cetuximab
40 QUILT-3.048: NANT Urothelial Cancer Vaccine: Combination Immunotherapy in Subjects With Urothelial Cancer Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03197571 Phase 1, Phase 2 capecitabine;cisplatin;cyclophosphamide;5Fluorouracil (5-FU);fulvestrant;leucovorin;nab-paclitaxel;Lovaza
41 QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC Not yet recruiting NCT03169777 Phase 1, Phase 2 capecitabine;Cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab paclitaxel;Lovaza;oxaliplatin
42 QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03169764 Phase 1, Phase 2 Capecitabine;Cisplatin;cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab-paclitaxel;Lovaza
43 QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors Not yet recruiting NCT03169738 Phase 1, Phase 2 Capecitabine;Cisplatin;cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab paclitaxel;Lovaza;Oxaliplatin
44 QUILT-3.057: NANT Neoadjuvant Triple- Negative Breast Cancer (TNBC) Vaccine Not yet recruiting NCT03554109 Phase 2 Leucovorin;5-Fluorouracil;Aldoxorubicin HCl;nab-Paclitaxel;Avelumab;Cyclophosphamide;Doxorubicin HCL;paclitaxel
45 QUILT-3.046: NANT Melanoma Vaccine: Combination Immunotherapy in Subjects With Melanoma Who Have Progressed On or After Chemotherapy and PD-1/PD-L1 Therapy Not yet recruiting NCT03167177 Phase 1, Phase 2 Capecitabine;Cisplatin;Cyclophosphamide;5-fluorouracil;Leucovorin;nab-paclitaxel;omega-3-acid ethyl esters
46 QUILT-3.051: NANT Ovarian Cancer Vaccine: Combination Immunotherapy in Subjects With Epithelial Ovarian Cancer Who Have Progressed on or After Standard-of-care (SoC) Therapy Not yet recruiting NCT03197584 Phase 1, Phase 2 Capecitabine;Cyclophosphamide;5-fluorouracil;Fulvestrant;Leucovorin;Paclitaxel;omega-3 acid ethyl esters;Oxaliplatin
47 NANT Triple Negative Breast Cancer (TNBC) Vaccine: Combination Immunotherapy in Subjects With TNBC Who Have Progressed on or After Anthracycline-based Chemotherapy Not yet recruiting NCT03175666 Phase 1, Phase 2 capecitabine;cisplatin;cyclophosphamide;5-Fluorouracil;Leucovorin;nab-paclitaxel;Lovaza
48 QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer Not yet recruiting NCT03574649 Phase 2 Nab-paclitaxel;Cisplatin;5Fluorouracil;Cyclophosphamide;Aldoxorubicin;Avelumab;ALT-803;Docetaxel;carboplatin
49 QUILT-3.045: NANT Merkel Cell Carcinoma (MCC) Vaccine: Combination Immunotherapy in Subjects With MCC Who Have Progressed on or After PD-L1 Therapy Not yet recruiting NCT03167164 Phase 1, Phase 2 Capecitabine;Cisplatin;Cyclophosphamide;5-fluorouracil;Leucovorin;nab-Paclitaxel;omega-3-acid ethyl esters
50 QUILT-3.052: NANT Non-Hodgkin Lymphoma (NHL) Vaccine: Combination Immunotherapy in Subjects With Relapsed CD20-positive NHL Not yet recruiting NCT03169790 Phase 1, Phase 2 capecitabine;cyclophosphamide;5-Fluorouracil (5-FU);leucovorin;nab-paclitaxel;Lovaza;Oxaliplatin;rituximab

Search NIH Clinical Center for Alzheimer Disease 5

Genetic Tests for Alzheimer Disease 5

Anatomical Context for Alzheimer Disease 5

MalaCards organs/tissues related to Alzheimer Disease 5:

41
Lung, Breast, Prostate, Liver, Bone, Testes, Endothelial

Publications for Alzheimer Disease 5

Variations for Alzheimer Disease 5

Expression for Alzheimer Disease 5

Search GEO for disease gene expression data for Alzheimer Disease 5.

Pathways for Alzheimer Disease 5

Pathways related to Alzheimer Disease 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.37 HTR2A SLC6A4
2 11.01 HTR2A SLC6A4
3 10.07 HTR2A SLC6A4

GO Terms for Alzheimer Disease 5

Biological processes related to Alzheimer Disease 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 8.96 HTR2A SLC6A4
2 memory GO:0007613 8.62 HTR2A SLC6A4

Sources for Alzheimer Disease 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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