AD5
MCID: ALZ050
MIFTS: 35

Alzheimer Disease 5 (AD5)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 5

MalaCards integrated aliases for Alzheimer Disease 5:

Name: Alzheimer Disease 5 57 12 70
Alzheimer's Disease 5 12 15
Ad5 57 12
Alzheimer Disease, Familial, Type 5 13
Alzheimer's Disease 5, Late Onset 12
Alzheimer Disease, Familial, 5 57
Alzheimer Disease, Familial 5 12
Alzheimer Disease-5 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
alzheimer disease 5:
Inheritance autosomal dominant inheritance
Onset and clinical course late onset


Classifications:



External Ids:

Disease Ontology 12 DOID:0110037
OMIM® 57 602096
ICD10 32 G30
MedGen 41 C1865868
SNOMED-CT via HPO 68 230267005 263681008 26929004
UMLS 70 C1865868

Summaries for Alzheimer Disease 5

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 12p11.23-q13.12.

MalaCards based summary : Alzheimer Disease 5, also known as alzheimer's disease 5, is related to ebola hemorrhagic fever and yellow fever. An important gene associated with Alzheimer Disease 5 is AD5 (Alzheimer Disease 5), and among its related pathways/superpathways are TRAF Pathway and NF-kappa B signaling pathway. Affiliated tissues include myeloid, spinal cord and heart, and related phenotype is alzheimer disease.

More information from OMIM: 602096

Related Diseases for Alzheimer Disease 5

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 15
Alzheimer Disease 6 Alzheimer Disease 7
Alzheimer Disease 4 Alzheimer Disease 8
Alzheimer Disease 3 Alzheimer Disease 9
Alzheimer Disease 10 Alzheimer Disease 11
Alzheimer Disease 12 Alzheimer Disease 13
Alzheimer Disease 14 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 ebola hemorrhagic fever 29.6 GTPBP1 DDX58
2 yellow fever 29.3 IL1B IL1A DDX58
3 severe acute respiratory syndrome 29.0 IL1B DDX58 ACE
4 alzheimer disease 11.1
5 ovarian cancer 10.2
6 retinoblastoma 10.2
7 glioma 10.1
8 glial tumor 10.1
9 glioblastoma 10.1
10 high grade glioma 10.1
11 human immunodeficiency virus infectious disease 10.1
12 47,xyy 10.1
13 osteogenic sarcoma 10.0
14 adenocarcinoma 10.0
15 indolent plasma cell myeloma 10.0 IL1B IL1A
16 arachnoiditis 10.0 IL1B IL1A
17 posterior urethral valves 10.0 AGTR1 ACE
18 stachybotrys chartarum 10.0 IL1B IL1A
19 hypertensive encephalopathy 10.0 AGTR1 ACE
20 meningococcemia 10.0 IL1B IL1A
21 hypertensive retinopathy 10.0 AGTR1 ACE
22 limbal stem cell deficiency 10.0 IL1B IL1A
23 fibromuscular dysplasia 10.0 AGTR1 ACE
24 renal artery disease 10.0 AGTR1 ACE
25 hypertensive nephropathy 10.0 AGTR1 ACE
26 laryngitis 10.0 IL1B IL1A
27 acute mountain sickness 10.0 AGTR1 ACE
28 vaginal discharge 9.9 IL1B IL1A
29 amyotrophic lateral sclerosis 1 9.9
30 renal cell carcinoma, nonpapillary 9.9
31 human immunodeficiency virus type 1 9.9
32 lung cancer susceptibility 3 9.9
33 gastric cancer 9.9
34 lateral sclerosis 9.9
35 kidney cancer 9.9
36 vaccinia 9.9
37 ovary adenocarcinoma 9.9
38 severe combined immunodeficiency 9.9
39 herpes simplex 9.9
40 spinal cord injury 9.9
41 irritant dermatitis 9.9 IL1B IL1A
42 scleral disease 9.9 IL1B ACE
43 periapical periodontitis 9.9 IL1B IL1A
44 bolivian hemorrhagic fever 9.9 GTPBP1 DDX58
45 raynaud disease 9.9 AGTR1 ACE
46 background diabetic retinopathy 9.9 IL1B ACE
47 chorioretinitis 9.9 IL1B ACE
48 argentine hemorrhagic fever 9.9 GTPBP1 DDX58
49 idiopathic neutropenia 9.9 IL1B IL1A
50 decubitus ulcer 9.8 IL1B IL1A

Graphical network of the top 20 diseases related to Alzheimer Disease 5:



Diseases related to Alzheimer Disease 5

Symptoms & Phenotypes for Alzheimer Disease 5

Human phenotypes related to Alzheimer Disease 5:

31
# Description HPO Frequency HPO Source Accession
1 alzheimer disease 31 HP:0002511

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
late-onset form of familial alzheimer disease (ad)

Misc:
onset at least 60 years

Clinical features from OMIM®:

602096 (Updated 20-May-2021)

Drugs & Therapeutics for Alzheimer Disease 5

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 5

Genetic Tests for Alzheimer Disease 5

Anatomical Context for Alzheimer Disease 5

MalaCards organs/tissues related to Alzheimer Disease 5:

40
Myeloid, Spinal Cord, Heart, Kidney, Lung, Ovary, Prostate

Publications for Alzheimer Disease 5

Articles related to Alzheimer Disease 5:

(show all 39)
# Title Authors PMID Year
1
Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. 57
12566388 2003
2
Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics. 57
11715112 2002
3
Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease. 57
11283204 2001
4
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. 57
11001930 2000
5
Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. 57
10712207 2000
6
Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. 57
9718052 1998
7
Genetic studies on chromosome 12 in late-onset Alzheimer disease. 57
9718053 1998
8
Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. 57
9333264 1997
9
Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy. 61
33165511 2020
10
14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. 61
32973044 2020
11
Quality of Life in relation to neuropsychiatric symptoms in Alzheimer's disease: 5-year prospective ALSOVA cohort study. 61
28067961 2018
12
Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease. 61
27889911 2017
13
Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population. 61
27534713 2016
14
Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy. 61
25895507 2015
15
Memory Brought to Mind. Five-Year Follow-Up of Case Finding and Intervention of Dementia in a Swedish Primary Health Care District. 61
29234772 2015
16
Regions of interest-based discriminant analysis of DaTSCAN SPECT and FDG-PET for the classification of dementia. 61
23357822 2013
17
What aspects of social network are protective for dementia? Not the quantity but the quality of social interactions is protective up to 15 years later. 61
20807876 2010
18
Predictors of need-driven behaviors in nursing home residents with dementia and associated certified nursing assistant burden. 61
20425649 2010
19
Untreated poor vision: a contributing factor to late-life dementia. 61
20150357 2010
20
Abundant extracellular myelin in the meninges of patients with multiple sclerosis. 61
19473295 2009
21
WITHDRAWN: Support for carers of people with Alzheimer's type dementia. 61
17636637 2007
22
Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community. 61
17299264 2007
23
No evidence of CRHR1 gene involvement in progressive supranuclear palsy. 61
17010515 2006
24
International conference on the healthy effect of virgin olive oil. 61
16008542 2005
25
How heritable is Alzheimer's disease late in life? Findings from Swedish twins. 61
14755721 2004
26
[Managing Alzheimer's disease. 5/6--agitation and aggression]. 61
12929535 2003
27
Correlations between P300 components and regional cerebral blood flows. 61
11535005 2001
28
Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease. 61
10867780 2000
29
Brain Iron and Zinc Contents of German Patients with Alzheimer Disease. 61
12214107 2000
30
Support for carers of people with Alzheimer's type dementia. 61
10796545 2000
31
Diagnosis of intracranial vasculitis: a multi-disciplinary approach. 61
9600195 1998
32
Loss of calcium-homeostatic mechanisms in polymorphonuclear leukocytes of demented and nondemented elderly subjects. 61
8406058 1993
33
Post-mortem proton magnetic resonance spectrometric measures of brain regions in patients with a pathological diagnosis of Alzheimer's disease and multi-infarct dementia. 61
1540758 1992
34
Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. 61
1752858 1991
35
[The Paquid research program on the epidemiology of dementia. Methods and initial results]. 61
2063070 1991
36
C-anaphases in lymphocyte cultures versus premature centromere division syndromes. 61
3276615 1988
37
Glutamate transmission and toxicity in Alzheimer's disease. 61
2900537 1988
38
Possible mechanisms involved in the presynaptic cholinotoxicity due to ethylcholine aziridinium (AF64A) in vivo. 61
6330483 1984
39
Delirium and stereotypy from anticholinergic antiparkinson drugs. 61
7202232 1982

Variations for Alzheimer Disease 5

Expression for Alzheimer Disease 5

Search GEO for disease gene expression data for Alzheimer Disease 5.

Pathways for Alzheimer Disease 5

Pathways related to Alzheimer Disease 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.15 TNFAIP3 IL1B IL1A AGTR1
2 11.45 TNFAIP3 IL1B DDX58
3 11.33 IL1B IL1A AGTR1
4 11.13 IL7R IL1B IL1A
5 9.47 IL1B IL1A

GO Terms for Alzheimer Disease 5

Biological processes related to Alzheimer Disease 5 according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 TNFAIP3 IL1B IL1A AGTR1 ACOD1
2 cellular response to lipopolysaccharide GO:0071222 9.67 TNFAIP3 IL1B IL1A ACOD1
3 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL1A DDX58
4 regulation of blood vessel diameter GO:0097746 9.56 AGTR1 ACE
5 regulation of vasoconstriction GO:0019229 9.55 AGTR1 ACE
6 regulation of nitric-oxide synthase activity GO:0050999 9.54 IL1B IL1A
7 negative regulation of innate immune response GO:0045824 9.52 TNFAIP3 ACOD1
8 negative regulation of toll-like receptor 4 signaling pathway GO:0034144 9.51 TNFAIP3 ACOD1
9 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.49 IL1B DDX58
10 negative regulation of toll-like receptor 2 signaling pathway GO:0034136 9.46 TNFAIP3 ACOD1
11 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 AGTR1 ACE
12 negative regulation of type I interferon production GO:0032480 9.33 TNFAIP3 DDX58 ACOD1
13 positive regulation of immature T cell proliferation in thymus GO:0033092 9.32 IL1B IL1A
14 fever generation GO:0001660 9.26 IL1B IL1A
15 negative regulation of gap junction assembly GO:1903597 8.96 IL1B ACE
16 tolerance induction to lipopolysaccharide GO:0072573 8.62 TNFAIP3 ACOD1

Molecular functions related to Alzheimer Disease 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1A
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Alzheimer Disease 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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