MCID: ALZ015
MIFTS: 23

Alzheimer Disease 6

Categories: Neuronal diseases, Rare diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Alzheimer Disease 6

MalaCards integrated aliases for Alzheimer Disease 6:

Name: Alzheimer Disease 6 57 12 13
Alzheimer Disease 6, Late-Onset 57 73
Ad6 57 12
Alzheimer Disease 6, Late Onset 12
Alzheimer Disease, Type 6 29
Alzheimer's Disease 6 12

Classifications:



External Ids:

OMIM 57 605526
Disease Ontology 12 DOID:0110038
ICD10 33 G30
MedGen 42 C1854187
UMLS 73 C1854187

Summaries for Alzheimer Disease 6

OMIM : 57 Alzheimer disease (AD) is a neurodegenerative disorder characterized by subtle onset of memory loss followed by a slowly progressive dementia. The great majority of AD cases are of late onset (LOAD) after age 65 years. LOAD shows complex, nonmendelian patterns of inheritance, and most likely results from the combined effects of variation in a number of genes as well as from environmental factors (summary by Grupe et al., 2006). The Alzheimer disease-6 (AD6) designation refers to a susceptibility locus on chromosome 10q. Although significant associations with several candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial (Grupe et al., 2006). For a discussion of genetic heterogeneity of Alzheimer disease, see 104300. (605526)

MalaCards based summary : Alzheimer Disease 6, also known as alzheimer disease 6, late-onset, is related to alzheimer disease and hepatitis c virus. An important gene associated with Alzheimer Disease 6 is AD6 (Alzheimer Disease 6). The drugs Ribavirin and interferons have been mentioned in the context of this disorder. Affiliated tissues include heart.

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 10q24.

Related Diseases for Alzheimer Disease 6

Symptoms & Phenotypes for Alzheimer Disease 6

Clinical features from OMIM:

605526

Drugs & Therapeutics for Alzheimer Disease 6

Drugs for Alzheimer Disease 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 1 36791-04-5 37542
2 interferons Phase 1
3 Cloricromen Phase 1
4 Vaccines Phase 1
5 Platelet Aggregation Inhibitors Phase 1
6 Interferon-alpha Phase 1
7
Menthol Approved Not Applicable 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Baricitinib (LY3009104) in Participants With Moderate to Severe Atopic Dermatitis Enrolling by invitation NCT03559270 Phase 3 Baricitinib
2 Study of a Novel Therapeutic Vaccine Against Hepatitis C Using Ad6NSmut and MVA-NSmut in Chronically Infected Patients Completed NCT01701336 Phase 1
3 A Study of a New Candidate Vaccine Against Hepatitis C Virus (HCV) Completed NCT01070407 Phase 1
4 Study of a Novel Therapeutic Vaccine for Hepatitis C Virus Completed NCT01094873 Phase 1
5 Three-Dose Regimen of MRKAd5+6 Trigene (V526) in Healthy Adults (V526-001)(COMPLETED) Completed NCT00850616 Phase 1
6 Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients Recruiting NCT03111017 Not Applicable

Search NIH Clinical Center for Alzheimer Disease 6

Genetic Tests for Alzheimer Disease 6

Genetic tests related to Alzheimer Disease 6:

# Genetic test Affiliating Genes
1 Alzheimer Disease, Type 6 29

Anatomical Context for Alzheimer Disease 6

MalaCards organs/tissues related to Alzheimer Disease 6:

41
Heart

Publications for Alzheimer Disease 6

Variations for Alzheimer Disease 6

Expression for Alzheimer Disease 6

Search GEO for disease gene expression data for Alzheimer Disease 6.

Pathways for Alzheimer Disease 6

GO Terms for Alzheimer Disease 6

Sources for Alzheimer Disease 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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