MCID: ALZ015
MIFTS: 24

Alzheimer Disease 6

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 6

MalaCards integrated aliases for Alzheimer Disease 6:

Name: Alzheimer Disease 6 58 12 13
Alzheimer Disease 6, Late-Onset 58 74
Ad6 58 12
Alzheimer Disease 6, Late Onset 12
Alzheimer Disease, Type 6 30
Alzheimer's Disease 6 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110038
OMIM 58 605526
ICD10 34 G30
MedGen 43 C1854187
UMLS 74 C1854187

Summaries for Alzheimer Disease 6

OMIM : 58 Alzheimer disease (AD) is a neurodegenerative disorder characterized by subtle onset of memory loss followed by a slowly progressive dementia. The great majority of AD cases are of late onset (LOAD) after age 65 years. LOAD shows complex, nonmendelian patterns of inheritance, and most likely results from the combined effects of variation in a number of genes as well as from environmental factors (summary by Grupe et al., 2006). The Alzheimer disease-6 (AD6) designation refers to a susceptibility locus on chromosome 10q. Although significant associations with several candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial (Grupe et al., 2006). For a discussion of genetic heterogeneity of Alzheimer disease, see 104300. (605526)

MalaCards based summary : Alzheimer Disease 6, also known as alzheimer disease 6, late-onset, is related to alzheimer disease and alzheimer disease 5. An important gene associated with Alzheimer Disease 6 is AD6 (Alzheimer Disease 6). The drugs Ribavirin and Cloricromen have been mentioned in the context of this disorder. Affiliated tissues include heart.

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 10q24.

Related Diseases for Alzheimer Disease 6

Graphical network of the top 20 diseases related to Alzheimer Disease 6:



Diseases related to Alzheimer Disease 6

Symptoms & Phenotypes for Alzheimer Disease 6

Clinical features from OMIM:

605526

Drugs & Therapeutics for Alzheimer Disease 6

Drugs for Alzheimer Disease 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 1 36791-04-5 37542
2 Cloricromen Experimental Phase 1 68206-94-0
3 Vaccines Phase 1
4 Interferon-alpha Phase 1
5 Immunologic Factors Phase 1
6 Platelet Aggregation Inhibitors Phase 1
7 interferons Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Baricitinib (LY3009104) in Participants With Moderate to Severe Atopic Dermatitis Enrolling by invitation NCT03559270 Phase 3 Baricitinib
2 Study of a Novel Therapeutic Vaccine Against Hepatitis C Using Ad6NSmut and MVA-NSmut in Chronically Infected Patients Completed NCT01701336 Phase 1
3 A Study of a New Candidate Vaccine Against Hepatitis C Virus (HCV) Completed NCT01070407 Phase 1
4 Study of a Novel Therapeutic Vaccine for Hepatitis C Virus Completed NCT01094873 Phase 1
5 Three-Dose Regimen of MRKAd5+6 Trigene (V526) in Healthy Adults (V526-001)(COMPLETED) Completed NCT00850616 Phase 1
6 Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients Recruiting NCT03111017 Not Applicable

Search NIH Clinical Center for Alzheimer Disease 6

Genetic Tests for Alzheimer Disease 6

Genetic tests related to Alzheimer Disease 6:

# Genetic test Affiliating Genes
1 Alzheimer Disease, Type 6 30

Anatomical Context for Alzheimer Disease 6

MalaCards organs/tissues related to Alzheimer Disease 6:

42
Heart

Publications for Alzheimer Disease 6

Articles related to Alzheimer Disease 6:

# Title Authors Year
1
Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study. ( 19700948 )
2009

Variations for Alzheimer Disease 6

Expression for Alzheimer Disease 6

Search GEO for disease gene expression data for Alzheimer Disease 6.

Pathways for Alzheimer Disease 6

GO Terms for Alzheimer Disease 6

Sources for Alzheimer Disease 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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