AD6
MCID: ALZ015
MIFTS: 26

Alzheimer Disease 6 (AD6)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 6

MalaCards integrated aliases for Alzheimer Disease 6:

Name: Alzheimer Disease 6 57 12 13
Alzheimer Disease 6, Late-Onset 57 70
Alzheimer's Disease 6 12 15
Ad6 57 12
Alzheimer Disease 6, Late Onset 12
Alzheimer Disease, Type 6 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0110038
OMIM® 57 605526
ICD10 32 G30
MedGen 41 C1854187
UMLS 70 C1854187

Summaries for Alzheimer Disease 6

OMIM® : 57 Alzheimer disease (AD) is a neurodegenerative disorder characterized by subtle onset of memory loss followed by a slowly progressive dementia. The great majority of AD cases are of late onset (LOAD) after age 65 years. LOAD shows complex, nonmendelian patterns of inheritance, and most likely results from the combined effects of variation in a number of genes as well as from environmental factors (summary by Grupe et al., 2006). The Alzheimer disease-6 (AD6) designation refers to a susceptibility locus on chromosome 10q. Although significant associations with several candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial (Grupe et al., 2006). For a discussion of genetic heterogeneity of Alzheimer disease, see 104300. (605526) (Updated 20-May-2021)

MalaCards based summary : Alzheimer Disease 6, also known as alzheimer disease 6, late-onset, is related to hepatitis c virus and spastic paraplegia, intellectual disability, nystagmus, and obesity. An important gene associated with Alzheimer Disease 6 is AD6 (Alzheimer Disease 6), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. Affiliated tissues include brain, and related phenotype is skeleton.

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 10q24.

Related Diseases for Alzheimer Disease 6

Graphical network of the top 20 diseases related to Alzheimer Disease 6:



Diseases related to Alzheimer Disease 6

Symptoms & Phenotypes for Alzheimer Disease 6

Clinical features from OMIM®:

605526 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Alzheimer Disease 6:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 8.92 ECE2 IAPP IDE TGFA

Drugs & Therapeutics for Alzheimer Disease 6

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 6

Genetic Tests for Alzheimer Disease 6

Genetic tests related to Alzheimer Disease 6:

# Genetic test Affiliating Genes
1 Alzheimer Disease, Type 6 29

Anatomical Context for Alzheimer Disease 6

MalaCards organs/tissues related to Alzheimer Disease 6:

40
Brain

Publications for Alzheimer Disease 6

Articles related to Alzheimer Disease 6:

(show all 40)
# Title Authors PMID Year
1
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. 57
21280075 2011
2
Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. 57
20142614 2010
3
CALHM1 polymorphism is not associated with late-onset Alzheimer disease. 57
19472444 2009
4
Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. 57
19241460 2009
5
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. 57
18585350 2008
6
No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. 57
17725684 2008
7
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. 57
17761686 2007
8
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. 57
17725986 2007
9
Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease. 57
17573676 2007
10
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. 57
17564960 2007
11
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. 57
16773580 2006
12
A genome-wide linkage analysis of dementia in the Amish. 57
16389594 2006
13
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. 57
16385451 2006
14
Brain activation in offspring of AD cases corresponds to 10q linkage. 57
15984011 2005
15
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. 57
15615772 2005
16
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. 57
14559775 2003
17
Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. 57
14517947 2003
18
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. 57
12898287 2003
19
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. 57
11810277 2001
20
Susceptibility locus for Alzheimer's disease on chromosome 10. 57
11125144 2000
21
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. 57
11125142 2000
22
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. 57
11125143 2000
23
Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. 61
33417599 2021
24
The Precarity of Older Adults Living Alone With Cognitive Impairment. 61
29373676 2019
25
Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data. 61
29124088 2017
26
In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial. 61
27252647 2016
27
Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration. 61
24242746 2014
28
Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease. 61
19501175 2009
29
Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study. 61
19700948 2009
30
[Experiences with the Eurotest in neuropsychological examinations. A screening test]. 61
17620262 2007
31
Celecoxib still on the market: but for whose benefit? 61
16285073 2005
32
NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant. 61
15142281 2004
33
[Facing Alzheimer's disease. 6/6--support for families]. 61
14562696 2003
34
[The application of Gallyas-Braak stainings in pathologic diagnosis of neurodegenerative diseases]. 61
11940310 2002
35
Alzheimer's disease: a review concerning immune response and microischemia. 61
11133269 2001
36
Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria. 61
9869320 1998
37
Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered? 61
8772802 1996
38
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. 61
2392569 1990
39
EEG brain mapping in evaluating the time-course of the central action of DUP 996--a new acetylcholine releasing drug. 61
2775607 1989
40
[Effect of biological fluids and brain extracts of persons with Alzheimer's disease on nerve tissue cultures]. 61
3765982 1986

Variations for Alzheimer Disease 6

Expression for Alzheimer Disease 6

Search GEO for disease gene expression data for Alzheimer Disease 6.

Pathways for Alzheimer Disease 6

Pathways related to Alzheimer Disease 6 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 IDE ECE2

GO Terms for Alzheimer Disease 6

Cellular components related to Alzheimer Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.62 TGFA IDE

Biological processes related to Alzheimer Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.16 IAPP ECE2
2 metabolic process GO:0008152 8.96 IDE ECE2
3 positive regulation of protein kinase B signaling GO:0051897 8.62 TGFA IAPP

Molecular functions related to Alzheimer Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.16 IDE ECE2
2 metalloendopeptidase activity GO:0004222 8.96 IDE ECE2
3 amyloid-beta binding GO:0001540 8.62 IDE IAPP

Sources for Alzheimer Disease 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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