AD8
MCID: ALZ016
MIFTS: 28

Alzheimer Disease 8 (AD8)

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Alzheimer Disease 8

MalaCards integrated aliases for Alzheimer Disease 8:

Name: Alzheimer Disease 8 57 12 13 70
Alzheimer's Disease 8 12 15
Ad8 57 12
Alzheimer's Disease 8, Late Onset 12
Alzheimer Disease, Familial, 8 57
Alzheimer Disease, Familial 8 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110041
OMIM® 57 607116
ICD10 32 G30
MedGen 41 C1846735
UMLS 70 C1846735

Summaries for Alzheimer Disease 8

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 20p12.2-q11.21.

MalaCards based summary : Alzheimer Disease 8, also known as alzheimer's disease 8, is related to alzheimer disease and dementia. An important gene associated with Alzheimer Disease 8 is AD8 (Alzheimer Disease 8), and among its related pathways/superpathways is Parkinsons Disease Pathway. Affiliated tissues include eye, cortex and brain.

More information from OMIM: 607116

Related Diseases for Alzheimer Disease 8

Diseases in the Alzheimer Disease family:

Alzheimer Disease 2 Alzheimer Disease 16
Alzheimer Disease 5 Alzheimer Disease 15
Alzheimer Disease 6 Alzheimer Disease 7
Alzheimer Disease 4 Alzheimer Disease 8
Alzheimer Disease 3 Alzheimer Disease 9
Alzheimer Disease 10 Alzheimer Disease 11
Alzheimer Disease 12 Alzheimer Disease 13
Alzheimer Disease 14 Alzheimer Disease 17
Alzheimer Disease 18 Alzheimer Disease 19
Alzheimer's Disease 1 Early-Onset, Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 11.0
2 dementia 10.5
3 mild cognitive impairment 10.3
4 keratitis, hereditary 10.0
5 acute hemorrhagic conjunctivitis 10.0
6 shipyard eye 10.0
7 conjunctivitis 10.0
8 keratoconjunctivitis 10.0
9 parkinson disease 10 10.0 PARK7 LRRK2
10 color agnosia 10.0 PARK7 LRRK2
11 postencephalitic parkinson disease 10.0 PARK7 LRRK2
12 parkinson disease 3, autosomal dominant 10.0 PARK7 LRRK2
13 parkinson disease 15, autosomal recessive early-onset 10.0 PARK7 LRRK2
14 kufor-rakeb syndrome 9.9 PARK7 LRRK2
15 amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 9.9 PARK7 LRRK2
16 parkinsonism 9.9 PARK7 LRRK2
17 gaucher disease, type i 9.9 PARK7 LRRK2
18 early-onset parkinson's disease 9.9 PARK7 LRRK2
19 toxic encephalopathy 9.9 PARK7 LRRK2
20 supranuclear palsy, progressive, 1 9.9 PARK7 LRRK2
21 prion disease 9.9 PARK7 LRRK2
22 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.9
23 migraine with or without aura 1 9.9
24 immune deficiency disease 9.9
25 major depressive disorder 9.9
26 human immunodeficiency virus type 1 9.9
27 mental depression 9.9
28 epilepsy 9.9
29 eye disease 9.9
30 subacute delirium 9.9
31 depression 9.9
32 gaucher's disease 9.9 PARK7 LRRK2
33 dementia, lewy body 9.8 PARK7 LRRK2
34 pick disease of brain 9.8 PARK7 LRRK2
35 parkinson disease 2, autosomal recessive juvenile 9.7 PARK7 LRRK2
36 movement disease 9.6 PARK7 LRRK2

Graphical network of the top 20 diseases related to Alzheimer Disease 8:



Diseases related to Alzheimer Disease 8

Symptoms & Phenotypes for Alzheimer Disease 8

Clinical features from OMIM®:

607116 (Updated 20-May-2021)

Drugs & Therapeutics for Alzheimer Disease 8

Search Clinical Trials , NIH Clinical Center for Alzheimer Disease 8

Genetic Tests for Alzheimer Disease 8

Anatomical Context for Alzheimer Disease 8

MalaCards organs/tissues related to Alzheimer Disease 8:

40
Eye, Cortex, Brain

Publications for Alzheimer Disease 8

Articles related to Alzheimer Disease 8:

(show all 31)
# Title Authors PMID Year
1
Cystatin C and apoe polymorphisms in Italian Alzheimer's disease. 57
16188386 2006
2
No association between the cystatin C gene polymorphism and Alzheimer's disease: a case-control study in an Italian population. 57
16131730 2005
3
Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease. 57
15034766 2004
4
A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region. 57
12016588 2002
5
The amyloid precursor protein locus and very-late-onset Alzheimer disease. 57
11500807 2001
6
Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. 57
11074789 2000
7
A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease. 57
10993992 2000
8
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. 57
9008509 1997
9
Modified STEADI Fall Risk Categories Predict Incident Cognitive Impairment. 61
33565618 2021
10
A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea. 61
30977313 2019
11
Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients. 61
29438114 2018
12
Prevalence of Dementia and Associated Risk Factors: A Population-Based Study in the Philippines. 61
29710725 2018
13
[Cognitive impairment as a predictor of functional decline after hospitalization: DECOFIRH Study]. 61
29071699 2017
14
Association between olfaction and higher cortical functions in Alzheimer's disease, mild cognitive impairment, and healthy older adults. 61
27868477 2017
15
Screening for dementia in Arabic: normative data from an elderly Lebanese sample. 61
28276861 2017
16
Diagnostic test accuracy of informant-based tools to diagnose dementia in older hospital patients with delirium: a prospective cohort study. 61
27076526 2016
17
Use of the Montreal Cognitive Assessment and Alzheimer's Disease-8 as cognitive screening measures in Parkinson's disease. 61
26177715 2016
18
Test Your Memory-Spanish version (TYM-S): a validation study of a self-administered cognitive screening test. 61
24390843 2014
19
The Alzheimer's disease-8 and Montreal Cognitive Assessment as screening tools for neurocognitive impairment in HIV-infected persons. 61
23345074 2013
20
Neuropsychological signs of Alzheimer's disease 8 years prior to diagnosis. 61
23254631 2013
21
Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly. 61
22038076 2012
22
Validity and reliability of the Korean version of the AD8 informant interview (K-AD8) in dementia. 61
19561437 2009
23
Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study. 61
15533991 2004
24
Using β-Secretase Inhibitors to Distiguish the Generation of the Aβ Peptides Terminating at Val-40 and Ala-42. 61
21318523 2000
25
Increased serum neopterin concentrations in patients with Alzheimer's disease. 61
10369114 1999
26
Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. 61
9428657 1997
27
[The effect of age and disease on the MR imaging T2 low signal intensity area in the cerebral cortex]. 61
7823405 1994
28
The Gospel Oak Study stage III: the incidence of dementia. 61
8208898 1994
29
Differences in erythrocyte aggregability between multi-infarct dementia and Alzheimer's disease. 61
26487254 1993
30
Sensitivity and specificity of death certificate diagnoses for dementing illnesses, 1988-1990. 61
1634701 1992
31
[The Paquid research program on the epidemiology of dementia. Methods and initial results]. 61
2063070 1991

Variations for Alzheimer Disease 8

Expression for Alzheimer Disease 8

Search GEO for disease gene expression data for Alzheimer Disease 8.

Pathways for Alzheimer Disease 8

Pathways related to Alzheimer Disease 8 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 PARK7 LRRK2

GO Terms for Alzheimer Disease 8

Biological processes related to Alzheimer Disease 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.43 MSRB2 LRRK2
2 cellular response to oxidative stress GO:0034599 9.4 PARK7 LRRK2
3 mitochondrion organization GO:0007005 9.37 PARK7 LRRK2
4 negative regulation of protein binding GO:0032091 9.32 PARK7 LRRK2
5 negative regulation of neuron death GO:1901215 9.26 PARK7 LRRK2
6 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.16 PARK7 LRRK2
7 negative regulation of hydrogen peroxide-induced cell death GO:1903206 8.96 PARK7 LRRK2
8 negative regulation of protein phosphorylation GO:0001933 8.8 PARK7 MICAL1 LRRK2

Molecular functions related to Alzheimer Disease 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.13 PARK7 MYOM3 LRRK2
2 actin binding GO:0003779 8.8 MSRB2 MICAL1 LRRK2

Sources for Alzheimer Disease 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....