MCID: AMR003
MIFTS: 39

Amaurosis Fugax

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Amaurosis Fugax

MalaCards integrated aliases for Amaurosis Fugax:

Name: Amaurosis Fugax 54 30
Transient Monocular Blindness 54

Classifications:



External Ids:

ICD10 34 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to carotid artery disease and carotid stenosis. An important gene associated with Amaurosis Fugax is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Complement and coagulation cascades and Degradation of the extracellular matrix. The drugs Clopidogrel and Purinergic P2Y Receptor Antagonists have been mentioned in the context of this disorder. Affiliated tissues include eye, prostate and lung, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 77 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 carotid artery disease 30.8 MMP8 MMP9
2 carotid stenosis 30.6 MMP9 MTHFR
3 arteries, anomalies of 30.6 MMP9 SERPINE1
4 ischemic optic neuropathy 30.0 F5 MTHFR
5 protein c deficiency 30.0 F5 MTHFR
6 nonarteritic anterior ischemic optic neuropathy 30.0 F5 MTHFR
7 thrombophilia 29.9 F5 MTHFR SERPINE1
8 patent foramen ovale 29.9 F5 MTHFR
9 retinal artery occlusion 29.8 F5 MTHFR SERPINE1
10 stroke, ischemic 29.5 F5 MTHFR SERPINE1
11 thrombosis 29.3 F5 MTHFR SERPINE1
12 lupus erythematosus 10.3
13 headache 10.3
14 systemic lupus erythematosus 10.2
15 arteriovenous fistula 10.2
16 arteriovenous malformation 10.2
17 branch retinal artery occlusion 10.2
18 atrial heart septal defect 10.2
19 optic nerve disease 10.2
20 carotid artery occlusion 10.2
21 vasculitis 10.2
22 neuropathy 10.2
23 hemiplegia 10.2
24 fungal keratitis 10.2 MMP8 MMP9
25 pelvic organ prolapse 10.1 MMP8 MMP9
26 rosacea 10.1 MMP8 MMP9
27 preterm premature rupture of the membranes 10.1 MMP8 MMP9
28 aortic aneurysm, familial abdominal, 1 10.1 MMP8 MMP9
29 appendicitis 10.1 MMP8 MMP9
30 bronchiolitis obliterans 10.1 MMP8 MMP9
31 pulmonary emphysema 10.1 MMP8 MMP9
32 aortic valve disease 1 10.1
33 cervical rib 10.1
34 renal cell carcinoma, nonpapillary 10.1
35 prostate cancer 10.1
36 temporal arteritis 10.1
37 takayasu arteritis 10.1
38 chondrosarcoma 10.1
39 polycythemia vera 10.1
40 yemenite deaf-blind hypopigmentation syndrome 10.1
41 prostate cancer, hereditary, 8 10.1
42 orthostatic intolerance 10.1
43 prostate cancer, hereditary, 6 10.1
44 lung cancer susceptibility 3 10.1
45 microvascular complications of diabetes 5 10.1
46 cataract 10.1
47 crohn's disease 10.1
48 hemangioma 10.1
49 human venous malformation 10.1
50 cysticercosis 10.1

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
2 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
3 Neurotransmitter Agents Phase 4,Phase 3
4 Platelet Aggregation Inhibitors Phase 4,Phase 3
5 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
6
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
7
Ticagrelor Approved Phase 3 274693-27-5 9871419
8 Antirheumatic Agents Phase 3
9 Analgesics Phase 3
10 lysine Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Antipyretics Phase 3
16 Acetylsalicylic acid lysinate Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Fibrinolytic Agents Phase 3
19
Mannitol Approved, Investigational Phase 2 69-65-8 6251 453
20 Natriuretic Agents Phase 2
21 diuretics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
2 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
3 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Completed NCT01645306 Phase 2 Revacept;Placebo
4 Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613 Not Applicable
5 Reproducibility Study of Transcranial Doppler Completed NCT03050567
6 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT) Completed NCT00402740 Not Applicable
7 Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery Recruiting NCT03669042 Not Applicable
8 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
9 Medtronic CoreValve Evolut R U.S. Clinical Study Active, not recruiting NCT02207569 Not Applicable

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

# Genetic test Affiliating Genes
1 Amaurosis Fugax 30

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

42
Eye, Prostate, Lung, Heart, Endothelial, Testes, Pituitary

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 251)
# Title Authors Year
1
Amaurosis fugax as the presenting symptom of metastatic lung adenocarcinoma. ( 31109501 )
2019
2
Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report. ( 31097325 )
2019
3
A case report of isolated orbital vasculitis mimicking retinal migraine: A potential cause of recurrent transient monocular blindness and ipsilateral headache. ( 30099954 )
2019
4
Lights Out: An Unusual Case of Amaurosis Fugax. ( 28917646 )
2018
5
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
6
Transient monocular blindness: Vascular causes and differential diagnoses. ( 29673627 )
2018
7
Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots. ( 29260101 )
2017
8
Limb-Shaking Syndrome with Light-Induced Amaurosis Fugax: A Rare Presentation of Near-Occlusive Carotid Disease. ( 30838283 )
2017
9
Charles Miller Fisher: the 65th anniversary of the publication of his groundbreaking study "Transient Monocular Blindness Associated with Hemiplegia". ( 29166469 )
2017
10
Amaurosis fugax associated with congenital vascular defect. ( 27445507 )
2016
11
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. ( 27826182 )
2016
12
Amaurosis fugax - delay between symptoms and surgery by specialty. ( 27895459 )
2016
13
Amaurosis fugax due to pleomorphic sarcoma in the left atrium. ( 29503917 )
2016
14
Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study. ( 27314958 )
2016
15
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. ( 25613128 )
2015
16
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. ( 25617405 )
2015
17
Amaurosis Fugax Captured During Fluorescein Angiography. ( 26049618 )
2015
18
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. ( 26234004 )
2015
19
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. ( 26283520 )
2015
20
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. ( 26438683 )
2015
21
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. ( 26605943 )
2015
22
Headache and amaurosis fugax in an obese woman. ( 26627820 )
2015
23
Amaurosis fugax in ocular vascular occlusive disorders: prevalence and pathogeneses. ( 23632956 )
2014
24
Young patient with headache and amaurosis fugax. ( 24193794 )
2014
25
Amaurosis fugax caused by neurocysticercosis. ( 24632665 )
2014
26
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. ( 24957310 )
2014
27
ECG of the Month. Amaurosis Fugax in a 45-Year-Old Woman. DIAGNOSIS: Normal sinus rhythm; left atrial enlargement. ( 25075509 )
2014
28
Features of patients with transient monocular blindness: a multicenter retrospective study in Japan. ( 24144597 )
2014
29
A rare but important differential diagnosis in transient monocular blindness. ( 25336309 )
2014
30
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. ( 23365782 )
2013
31
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. ( 23509049 )
2013
32
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. ( 23568216 )
2013
33
Does amaurosis fugax after retrobulbar injection need any treatment? ( 23595404 )
2013
34
Cervical rib resulting in amaurosis fugax and stroke. ( 24035686 )
2013
35
Takayasu retinopathy presenting as amaurosis fugax in a young patient. ( 25390509 )
2013
36
Recurrent transient monocular blindness from stenotic central retinal artery. ( 23830588 )
2013
37
Clopidogrel effective for frequent transient monocular blindness caused by vulnerable plaque. ( 23845263 )
2013
38
Internal jugular venous abnormalities in transient monocular blindness. ( 23876171 )
2013
39
Angiographically documented transient monocular blindness: retinal migraine? ( 24021459 )
2013
40
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. ( 21831902 )
2012
41
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. ( 23198268 )
2012
42
Patent foramen ovale presenting with amaurosis fugax. ( 23472288 )
2012
43
Don't forget amaurosis fugax. ( 21690157 )
2011
44
Sleep-induced amaurosis fugax. ( 21723066 )
2011
45
Diagnosing amaurosis fugax with emergency ultrasound. ( 20015107 )
2010
46
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. ( 20434591 )
2010
47
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. ( 20934672 )
2010
48
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. ( 21302720 )
2010
49
Jugular venous reflux affects ocular venous system in transient monocular blindness. ( 19955735 )
2010
50
From amaurosis fugax to asymptomatic bithalamic infarct. ( 19252800 )
2009

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 F5 SERPINE1
2
Show member pathways
11.45 MMP8 MMP9 SERPINE1
3 11.35 MMP9 SERPINE1
4
Show member pathways
11.15 MMP8 MMP9
5 10.74 MMP9 SERPINE1

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 F5 MMP8 MMP9 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.16 F5 SERPINE1
3 tertiary granule lumen GO:1904724 8.96 MMP8 MMP9
4 collagen-containing extracellular matrix GO:0062023 8.8 MMP8 MMP9 SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.4 F5 SERPINE1
2 extracellular matrix disassembly GO:0022617 9.37 MMP8 MMP9
3 blood circulation GO:0008015 9.32 F5 MTHFR
4 collagen catabolic process GO:0030574 9.26 MMP8 MMP9
5 positive regulation of DNA binding GO:0043388 9.16 MMP8 MMP9
6 endodermal cell differentiation GO:0035987 8.96 MMP8 MMP9
7 regulation of neuroinflammatory response GO:0150077 8.62 MMP8 MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP8 MMP9
2 endopeptidase activity GO:0004175 8.62 MMP8 MMP9

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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