MCID: AMR003
MIFTS: 38

Amaurosis Fugax

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Amaurosis Fugax

MalaCards integrated aliases for Amaurosis Fugax:

Name: Amaurosis Fugax 53 29
Transient Monocular Blindness 53

Classifications:



External Ids:

ICD10 33 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to carotid artery disease and patent foramen ovale. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways/superpathways are Complement and coagulation cascades and Degradation of the extracellular matrix. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and pituitary, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 76 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 carotid artery disease 30.3 MMP8 MMP9
2 patent foramen ovale 29.8 F5 MTHFR
3 protein c deficiency 29.7 F5 MTHFR
4 ischemic optic neuropathy 29.7 F5 MTHFR
5 nonarteritic anterior ischemic optic neuropathy 29.7 F5 MTHFR
6 carotid stenosis 29.5 MMP9 MTHFR
7 retinal artery occlusion 29.3 F5 MTHFR SERPINE1
8 thrombophilia 29.3 F5 MTHFR SERPINE1
9 arteries, anomalies of 29.1 MMP9 MTHFR SERPINE1
10 stroke, ischemic 28.9 F5 MTHFR SERPINE1
11 retinitis 10.5
12 transient cerebral ischemia 10.4
13 sticky platelet syndrome 10.3 F5 SERPINE1
14 meningococcemia 10.3 F5 SERPINE1
15 factor xiii deficiency 10.3 F5 SERPINE1
16 post-thrombotic syndrome 10.3 F5 SERPINE1
17 quebec platelet disorder 10.3 F5 SERPINE1
18 legg-calve-perthes disease 10.3 F5 SERPINE1
19 cerebritis 10.3
20 ischemic colitis 10.2 F5 MMP9
21 lupus erythematosus 10.2
22 headache 10.2
23 disseminated intravascular coagulation 10.1 F5 SERPINE1
24 rosacea 10.1 MMP8 MMP9
25 chronic venous insufficiency 10.1 MMP9 SERPINE1
26 systemic lupus erythematosus 10.1
27 arteriovenous fistula 10.1
28 arteriovenous malformation 10.1
29 central retinal artery occlusion 10.1
30 atrial heart septal defect 10.1
31 optic nerve disease 10.1
32 carotid artery occlusion 10.1
33 vasculitis 10.1
34 neuropathy 10.1
35 endotheliitis 10.1
36 venous insufficiency 10.1 MMP9 SERPINE1
37 pharynx cancer 10.0 MMP8 MMP9
38 severe pre-eclampsia 10.0 F5 MMP9
39 tongue cancer 10.0 MMP8 MMP9
40 appendicitis 10.0 MMP8 MMP9
41 pulmonary emphysema 10.0 MMP8 MMP9
42 chorioamnionitis 10.0 MMP8 MMP9
43 spinal cord infarction 10.0 F5 MTHFR
44 sudden sensorineural hearing loss 10.0 F5 MTHFR
45 bronchiolitis obliterans 10.0 MMP8 MMP9
46 porencephaly 10.0 F5 MTHFR
47 intracranial thrombosis 10.0 F5 MTHFR
48 retinal vascular occlusion 10.0 F5 MTHFR
49 antithrombin iii deficiency 10.0 F5 MTHFR
50 central retinal vein occlusion 9.9 F5 MTHFR

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
2
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
3 Fibrinolytic Agents Phase 4,Phase 3
4 Neurotransmitter Agents Phase 4,Phase 3
5 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
6 Platelet Aggregation Inhibitors Phase 4,Phase 3
7 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
8 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
9
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
10
Ticagrelor Approved Phase 3 274693-27-5 9871419
11 Analgesics Phase 3
12 Acetylsalicylic acid lysinate Phase 3
13 Cyclooxygenase Inhibitors Phase 3
14 Analgesics, Non-Narcotic Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Antipyretics Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Antirheumatic Agents Phase 3
20 lysine Nutraceutical Phase 3
21
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
22 diuretics Phase 2
23 Natriuretic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
2 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
3 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Recruiting NCT01645306 Phase 2 Revacept;Placebo
4 Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613 Not Applicable
5 Reproducibility Study of Transcranial Doppler Completed NCT03050567
6 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT) Completed NCT00402740 Not Applicable
7 Medtronic CoreValve Evolut R U.S. Clinical Study Active, not recruiting NCT02207569 Not Applicable

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

# Genetic test Affiliating Genes
1 Amaurosis Fugax 29

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

41
Eye, Endothelial, Pituitary, Prostate

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 197)
# Title Authors Year
1
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
2
Lights Out: an Unusual Case of Amaurosis Fugax. ( 28917646 )
2017
3
Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots. ( 29260101 )
2017
4
Amaurosis Fugax ( 29261995 )
2017
5
Amaurosis fugax - delay between symptoms and surgery by specialty. ( 27895459 )
2016
6
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. ( 27826182 )
2016
7
Amaurosis fugax due to pleomorphic sarcoma in the left atrium. ( 29503917 )
2016
8
Amaurosis fugax associated with congenital vascular defect. ( 27445507 )
2016
9
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. ( 25617405 )
2015
10
Amaurosis Fugax Captured During Fluorescein Angiography. ( 26049618 )
2015
11
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. ( 26234004 )
2015
12
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. ( 26283520 )
2015
13
Headache and amaurosis fugax in an obese woman. ( 26627820 )
2015
14
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. ( 26438683 )
2015
15
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. ( 26605943 )
2015
16
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. ( 25613128 )
2015
17
Amaurosis fugax caused by neurocysticercosis. ( 24632665 )
2014
18
ECG of the Month: Amaurosis Fugax in a 45-Year-Old Woman. ( 25075509 )
2014
19
Young patient with headache and amaurosis fugax. ( 24193794 )
2014
20
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. ( 24957310 )
2014
21
AMAUROSIS FUGAX IN OCULAR VASCULAR OCCLUSIVE DISORDERS: Prevalence and Pathogeneses. ( 23632956 )
2014
22
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. ( 23568216 )
2013
23
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. ( 23365782 )
2013
24
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. ( 23509049 )
2013
25
Takayasu retinopathy presenting as amaurosis fugax in a young patient. ( 25390509 )
2013
26
Does amaurosis fugax after retrobulbar injection need any treatment? ( 23595404 )
2013
27
Cervical rib resulting in amaurosis fugax and stroke. ( 24035686 )
2013
28
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. ( 21831902 )
2012
29
Patent foramen ovale presenting with amaurosis fugax. ( 23472288 )
2012
30
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. ( 23198268 )
2012
31
Don't forget amaurosis fugax. ( 21690157 )
2011
32
Sleep-induced amaurosis fugax. ( 21723066 )
2011
33
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. ( 20934672 )
2010
34
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. ( 20434591 )
2010
35
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. ( 21302720 )
2010
36
Diagnosing amaurosis fugax with emergency ultrasound. ( 20015107 )
2010
37
From amaurosis fugax to asymptomatic bithalamic infarct. ( 19252800 )
2009
38
Optic neuritis presenting with amaurosis fugax. ( 19727900 )
2009
39
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene. ( 19507653 )
2009
40
Time to carotid endarterectomy. Don't forget amaurosis fugax. ( 19564188 )
2009
41
Common carotid artery stenosis and amaurosis fugax. ( 18190813 )
2008
42
Novel mouse model of monocular amaurosis fugax. ( 17975099 )
2007
43
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. ( 17456620 )
2007
44
Amaurosis fugax secondary to imaging methods of MRI scan. ( 17178375 )
2007
45
Amaurosis fugax caused by retinal artery vasospasm. Case illustration. ( 17542546 )
2007
46
Recurrent anterior chamber hemorrhage from an intraocular lens simulating amaurosis fugax. ( 17662452 )
2007
47
Endoscopic epinephrine injection induced amaurosis fugax. ( 16911707 )
2006
48
Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. ( 16376194 )
2005
49
Amaurosis fugax: associations with heritable thrombophilia. ( 16015408 )
2005
50
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? ( 16137504 )
2005

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 F5 SERPINE1
2
Show member pathways
11.45 MMP8 MMP9 SERPINE1
3 11.35 MMP9 SERPINE1
4
Show member pathways
11.15 MMP8 MMP9
5 10.74 MMP9 SERPINE1

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 F5 MMP8 MMP9 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.16 F5 SERPINE1
3 tertiary granule lumen GO:1904724 8.96 MMP8 MMP9
4 extracellular matrix GO:0031012 8.8 MMP8 MMP9 SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.32 F5 SERPINE1
2 extracellular matrix disassembly GO:0022617 9.26 MMP8 MMP9
3 collagen catabolic process GO:0030574 9.16 MMP8 MMP9
4 blood circulation GO:0008015 8.96 F5 MTHFR
5 endodermal cell differentiation GO:0035987 8.62 MMP8 MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.62 MMP8 MMP9

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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