MCID: AMR003
MIFTS: 36

Amaurosis Fugax

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Amaurosis Fugax

MalaCards integrated aliases for Amaurosis Fugax:

Name: Amaurosis Fugax 53 29 33
Transient Monocular Blindness 53

Classifications:



External Ids:

ICD10 33 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to retinal vascular occlusion and carotid artery disease. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways/superpathways are Complement and coagulation cascades and Degradation of the extracellular matrix. The drugs Mannitol and Natriuretic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 75 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 32.1 MTHFR F5
2 carotid artery disease 31.0 MMP9 MMP8
3 carotid stenosis 30.7 MTHFR MMP9
4 arteries, anomalies of 30.5 SERPINE1 MMP9
5 antiphospholipid syndrome 30.4 MTHFR F5
6 nonarteritic anterior ischemic optic neuropathy 30.2 MTHFR F5
7 patent foramen ovale 30.1 MTHFR F5
8 central retinal vein occlusion 30.1 MTHFR F5
9 protein c deficiency 30.0 MTHFR F5
10 retinal artery occlusion 30.0 SERPINE1 MTHFR F5
11 homocysteinemia 29.8 MTHFR F5
12 primary angle-closure glaucoma 29.8 MTHFR MMP9
13 thrombophilia 29.7 SERPINE1 MTHFR F5
14 stroke, ischemic 29.7 SERPINE1 MTHFR F5
15 homocystinuria 29.7 MTHFR F5
16 retinal vein occlusion 29.4 SERPINE1 MTHFR F5
17 vascular disease 29.1 SERPINE1 MTHFR MMP9 F5
18 cerebrovascular disease 29.0 SERPINE1 MTHFR MMP9 F5
19 myocardial infarction 28.5 SERPINE1 MTHFR MMP9 F5
20 retinal ischemia 11.8
21 yemenite deaf-blind hypopigmentation syndrome 10.8
22 migraine with or without aura 1 10.6
23 vasculitis 10.5
24 branch retinal artery occlusion 10.5
25 transient cerebral ischemia 10.5
26 headache 10.4
27 systemic lupus erythematosus 10.4
28 central retinal artery occlusion 10.4
29 optic nerve disease 10.4
30 carotid artery occlusion 10.4
31 arteriovenous malformation 10.3
32 lupus erythematosus 10.3
33 pure autonomic failure 10.3
34 sticky platelet syndrome 10.3 SERPINE1 F5
35 quebec platelet disorder 10.2 SERPINE1 F5
36 meningococcemia 10.2 SERPINE1 F5
37 temporal arteritis 10.2
38 takayasu arteritis 10.2
39 asplenia, isolated congenital 10.2
40 orthostatic intolerance 10.2
41 intraocular pressure quantitative trait locus 10.2
42 cardiac arrest 10.2
43 heart septal defect 10.2
44 atrial heart septal defect 10.2
45 retinal vascular disease 10.2
46 hemangioma 10.2
47 cavernous hemangioma 10.2
48 neuropathy 10.2
49 exophthalmos 10.2
50 47,xyy 10.2

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
2 Natriuretic Agents Phase 2
3 diuretics Phase 2
4
Selenium Approved, Investigational, Vet_approved Early Phase 1 7782-49-2
5
Melatonin Approved, Nutraceutical, Vet_approved Early Phase 1 73-31-4 896
6 Micronutrients Early Phase 1
7 Antioxidants Early Phase 1
8 Protective Agents Early Phase 1
9 Nutrients Early Phase 1
10 Trace Elements Early Phase 1
11 Central Nervous System Depressants Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
2 Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups Completed NCT01645306 Phase 2 Revacept;Placebo
3 CANOPY: Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613
4 TransCarotid Revascularization Surveillance Project of the Society for Vascular Surgery Vascular Quality Initiative Recruiting NCT02850588
5 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
6 Multimodal Imaging Analysis, OCT-angiography (Optical Coherence Tomography) and SD-OCT (Spectral Domain Optical Coherence Tomography), of Retinal and Choroidal Variations Observed After a Revascularization Procedure on the Internal Carotid Artery Not yet recruiting NCT03939351
7 Determine the Effects of Selenium and Melatonin on Ocular Ischemic Syndrome Not yet recruiting NCT04005222 Early Phase 1 SELENIUM;MELATONIN

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

# Genetic test Affiliating Genes
1 Amaurosis Fugax 29

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

41
Eye, Brain, Testes, Endothelial, Retina, B Cells, Smooth Muscle

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 940)
# Title Authors PMID Year
1
Atypical presentation of giant cell arteritis in a patient with vertebrobasilar stroke: A case report. 38
31393385 2019
2
Carotid Endarterectomy in a Patient With Type 2 Myocardial Infarction During Preparation for Surgery: A Case Report. 38
30985316 2019
3
Carotid Plaque Positron Emission Tomography Imaging and Cerebral Ischemic Disease. 38
31272325 2019
4
Last neurologic event is associated with risk of in-hospital stroke or death after carotid endarterectomy or carotid artery stenting: Secondary data analysis of the German statutory quality assurance database. 38
31416653 2019
5
Risk of emergent carotid endarterectomy varies by type of presenting symptoms. 38
30777684 2019
6
Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report. 38
31097325 2019
7
Amaurosis fugax as the presenting symptom of metastatic lung adenocarcinoma. 38
31109501 2019
8
Neuro-Ophthalmic Symptoms of Primary Headache Disorders: Why the Patient With Headache May Present to Neuro-Ophthalmology. 38
31022065 2019
9
A case report of isolated orbital vasculitis mimicking retinal migraine: A potential cause of recurrent transient monocular blindness and ipsilateral headache. 38
30099954 2019
10
[Acute visual loss related to sphenoid meningioma]. 38
30926270 2019
11
CRAO in Moyamoya Syndrome Associated With Southampton Hemoglobinopathy. 38
31100171 2019
12
Homocysteinemia as a cause for amaurosis fugax in a patient without an apparent embolic source. 38
31334400 2019
13
Pre-Operative Masseter Area is an Independent Predictor of Long-Term Survival after Carotid Endarterectomy. 38
30583960 2019
14
Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report. 38
30762766 2019
15
[Ocular ischemic syndrome: clinical manifestations, diagnosis and evolution after treatment.] 38
30882345 2019
16
Stroke Risk Before and After Central Retinal Artery Occlusion in a US Cohort. 38
30711121 2019
17
Rate of strokes 1 year after retinal artery occlusion with analysis of risk groups. 38
30782009 2019
18
Guidelines for ultrasound examination in ophthalmology. Part III: Color Doppler ultrasonography. 38
31355585 2019
19
Symptomatic Carotid Atherosclerotic Plaques Are Associated With Increased Infiltration of Natural Killer (NK) Cells and Higher Serum Levels of NK Activating Receptor Ligands. 38
31354703 2019
20
Safety of Early Carotid Artery Stenting for Symptomatic Stenosis in Daily Practice. 38
30177414 2018
21
Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? 38
30060907 2018
22
Statin-induced myopathy prevented by creatine administration. 38
30150340 2018
23
Angiography with the 256-multislice spiral computed tomography and its application in evaluating atherosclerotic plaque and cerebral ischemia. 38
30045262 2018
24
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. 38
29653415 2018
25
Comparison of Clinical Characteristics among Subtypes of Visual Symptoms in Patients with Transient Ischemic Attack: Analysis of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA) Registry. 38
29525079 2018
26
A Stab in the Dark: A Case Report of an Atypical Presentation of Giant Cell Arteritis (GCA). 38
31011074 2018
27
Contrast-enhanced transoral carotid ultrasonography for the diagnosis and follow-up of extracranial internal carotid artery dissection: A case report. 38
28990690 2018
28
[Transient monocular blindness: Vascular causes and differential diagnoses]. 38
29776764 2018
29
Factors associated with delay in carotid endarterectomy for patients with symptomatic severe internal carotid artery stenosis: a case-control study. 38
29769180 2018
30
Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability. 38
29618596 2018
31
Occlusion rates of intracranial aneurysms treated with the Pipeline embolization device: the role of branches arising from the sac. 38
29624153 2018
32
Transient monocular blindness: Vascular causes and differential diagnoses. 38
29673627 2018
33
Carotid-Carotid Artery Crossover Bypass with a Synthetic Vascular Graft for Symptomatic Type 1A Common Carotid Artery Occlusion. 38
29269063 2018
34
Successful retinal blood flow augmentation after extracranial-intracranial bypass. 38
29071559 2018
35
Lights Out: An Unusual Case of Amaurosis Fugax. 38
28917646 2018
36
[Transient monocular blindness following intra-oral local anesthesia: Case report]. 38
29395590 2018
37
Pulsatile tinnitus and carotid artery dissection. 38
28126274 2018
38
Outcome following open and endovascular intervention for carotid stump syndrome. 38
29977555 2018
39
Crevice sign as an indicator of plaque laceration associated with postoperative severe thromboembolism after carotid artery stenting: a case report. 38
29238112 2017
40
Charles Miller Fisher: the 65th anniversary of the publication of his groundbreaking study "Transient Monocular Blindness Associated with Hemiplegia". 38
29166469 2017
41
Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots. 38
29260101 2017
42
[Imaging of vessels supplying the brain]. 38
28646330 2017
43
Outcomes of Carotid Endarterectomy with Primary Closure. 38
28566933 2017
44
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. 38
28386036 2017
45
PET/CT Imaging of Unstable Carotid Plaque with 68Ga-Labeled Somatostatin Receptor Ligand. 38
27932558 2017
46
Limb-Shaking Syndrome with Light-Induced Amaurosis Fugax: A Rare Presentation of Near-Occlusive Carotid Disease. 38
30838283 2017
47
One-Stage Angioplasty and Stenting of Ostium of Left Common Carotid Artery and Stenting of Left Internal Carotid Artery. 38
28188949 2017
48
The modified operative technique of partial eversion carotid endarterectomy. 38
28010865 2017
49
[Etiopathogenesis of ocular ischemic syndrome]. 38
28524151 2017
50
[Intracranial Pressure Evaluation by Ophthalmologist]. 38
28931297 2017

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SERPINE1 F5
2
Show member pathways
11.45 SERPINE1 MMP9 MMP8
3 11.35 SERPINE1 MMP9
4
Show member pathways
11.15 MMP9 MMP8
5 10.74 SERPINE1 MMP9

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SERPINE1 MMP9 MMP8 F5
2 platelet alpha granule lumen GO:0031093 9.16 SERPINE1 F5
3 tertiary granule lumen GO:1904724 8.96 MMP9 MMP8
4 collagen-containing extracellular matrix GO:0062023 8.8 SERPINE1 MMP9 MMP8

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.4 SERPINE1 F5
2 extracellular matrix disassembly GO:0022617 9.37 MMP9 MMP8
3 blood circulation GO:0008015 9.32 MTHFR F5
4 collagen catabolic process GO:0030574 9.26 MMP9 MMP8
5 positive regulation of DNA binding GO:0043388 9.16 MMP9 MMP8
6 endodermal cell differentiation GO:0035987 8.96 MMP9 MMP8
7 regulation of neuroinflammatory response GO:0150077 8.62 MMP9 MMP8

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP9 MMP8
2 endopeptidase activity GO:0004175 8.62 MMP9 MMP8

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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