MCID: AMR003
MIFTS: 37

Amaurosis Fugax

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Amaurosis Fugax

MalaCards integrated aliases for Amaurosis Fugax:

Name: Amaurosis Fugax 53 29
Transient Monocular Blindness 53

Classifications:



External Ids:

ICD10 33 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to carotid artery disease and arteries, anomalies of. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways/superpathways are Complement and coagulation cascades and Degradation of the extracellular matrix. The drugs Clopidogrel and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and prostate, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 76 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 carotid artery disease 30.5 MMP8 MMP9
2 arteries, anomalies of 30.5 MMP9 SERPINE1
3 thrombophilia 30.4 F5 MTHFR SERPINE1
4 ischemic optic neuropathy 30.3 F5 MTHFR
5 protein c deficiency 30.2 F5 MTHFR
6 carotid stenosis 30.2 MMP9 MTHFR
7 nonarteritic anterior ischemic optic neuropathy 30.2 F5 MTHFR
8 retinal artery occlusion 30.2 F5 MTHFR SERPINE1
9 patent foramen ovale 30.2 F5 MTHFR
10 stroke, ischemic 30.0 F5 MTHFR SERPINE1
11 thrombosis 29.8 F5 MTHFR SERPINE1
12 lupus erythematosus 10.3
13 headache 10.3
14 systemic lupus erythematosus 10.2
15 temporal arteritis 10.2
16 arteriovenous fistula 10.2
17 arteriovenous malformation 10.2
18 atrial heart septal defect 10.2
19 optic nerve disease 10.2
20 carotid artery occlusion 10.2
21 vasculitis 10.2
22 neuropathy 10.2
23 yemenite deaf-blind hypopigmentation syndrome 10.2
24 hemiplegia 10.2
25 antiphospholipid syndrome 10.1 F5 MTHFR
26 spinal cord infarction 10.1 F5 MTHFR
27 sudden sensorineural hearing loss 10.1 F5 MTHFR
28 sticky platelet syndrome 10.1 F5 SERPINE1
29 porencephaly 10.1 F5 MTHFR
30 quebec platelet disorder 10.1 F5 SERPINE1
31 retinal vascular occlusion 10.1 F5 MTHFR
32 meningococcemia 10.1 F5 SERPINE1
33 factor xiii deficiency 10.1 F5 SERPINE1
34 gastroschisis 10.1 F5 MTHFR
35 antithrombin iii deficiency 10.1 F5 MTHFR
36 post-thrombotic syndrome 10.1 F5 SERPINE1
37 central retinal vein occlusion 10.1 F5 MTHFR
38 intracranial thrombosis 10.1 F5 MTHFR
39 blood protein disease 10.1 F5 MTHFR
40 legg-calve-perthes disease 10.1 F5 SERPINE1
41 pulmonary artery disease 10.1 F5 MTHFR
42 arteritic anterior ischemic optic neuropathy 10.1 F5 MTHFR
43 aortic valve disease 1 10.1
44 cervical rib 10.1
45 renal cell carcinoma, nonpapillary 10.1
46 prostate cancer 10.1
47 takayasu arteritis 10.1
48 chondrosarcoma 10.1
49 polycythemia vera 10.1
50 orthostatic intolerance 10.1

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3 113665-84-2, 120202-66-6 60606
2
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
3 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
4 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
5 Platelet Aggregation Inhibitors Phase 4,Phase 3
6 Neurotransmitter Agents Phase 4,Phase 3
7 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
8 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 3
9 Fibrinolytic Agents Phase 4,Phase 3
10
Ticagrelor Approved Phase 3 274693-27-5 9871419
11
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
12 Analgesics Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Cyclooxygenase Inhibitors Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Antirheumatic Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Antipyretics Phase 3
19 Peripheral Nervous System Agents Phase 3
20 lysine Phase 3
21 Acetylsalicylic acid lysinate Phase 3
22
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
23 Natriuretic Agents Phase 2
24 diuretics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
2 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
3 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Completed NCT01645306 Phase 2 Revacept;Placebo
4 Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613 Not Applicable
5 Reproducibility Study of Transcranial Doppler Completed NCT03050567
6 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT) Completed NCT00402740 Not Applicable
7 Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery Recruiting NCT03669042 Not Applicable
8 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
9 Medtronic CoreValve Evolut R U.S. Clinical Study Active, not recruiting NCT02207569 Not Applicable

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

# Genetic test Affiliating Genes
1 Amaurosis Fugax 29

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

41
Eye, Endothelial, Prostate, Heart, Tongue, Spinal Cord, Placenta

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 239)
# Title Authors Year
1
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
2
A case report of isolated orbital vasculitis mimicking retinal migraine: A potential cause of recurrent transient monocular blindness and ipsilateral headache. ( 30099954 )
2018
3
Transient monocular blindness: Vascular causes and differential diagnoses. ( 29673627 )
2018
4
Lights Out: an Unusual Case of Amaurosis Fugax. ( 28917646 )
2017
5
Antiphosphospholipid syndrome presenting with amaurosis fugax and cotton wool spots. ( 29260101 )
2017
6
Amaurosis Fugax ( 29261995 )
2017
7
Amaurosis fugax - delay between symptoms and surgery by specialty. ( 27895459 )
2016
8
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. ( 27826182 )
2016
9
Amaurosis fugax due to pleomorphic sarcoma in the left atrium. ( 29503917 )
2016
10
Amaurosis fugax associated with congenital vascular defect. ( 27445507 )
2016
11
Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study. ( 27314958 )
2016
12
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. ( 25617405 )
2015
13
Amaurosis Fugax Captured During Fluorescein Angiography. ( 26049618 )
2015
14
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. ( 26234004 )
2015
15
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. ( 26283520 )
2015
16
Headache and amaurosis fugax in an obese woman. ( 26627820 )
2015
17
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. ( 26438683 )
2015
18
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. ( 26605943 )
2015
19
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. ( 25613128 )
2015
20
Amaurosis fugax caused by neurocysticercosis. ( 24632665 )
2014
21
ECG of the Month: Amaurosis Fugax in a 45-Year-Old Woman. ( 25075509 )
2014
22
Young patient with headache and amaurosis fugax. ( 24193794 )
2014
23
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. ( 24957310 )
2014
24
AMAUROSIS FUGAX IN OCULAR VASCULAR OCCLUSIVE DISORDERS: Prevalence and Pathogeneses. ( 23632956 )
2014
25
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. ( 23568216 )
2013
26
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. ( 23365782 )
2013
27
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. ( 23509049 )
2013
28
Takayasu retinopathy presenting as amaurosis fugax in a young patient. ( 25390509 )
2013
29
Does amaurosis fugax after retrobulbar injection need any treatment? ( 23595404 )
2013
30
Cervical rib resulting in amaurosis fugax and stroke. ( 24035686 )
2013
31
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. ( 21831902 )
2012
32
Patent foramen ovale presenting with amaurosis fugax. ( 23472288 )
2012
33
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. ( 23198268 )
2012
34
Don't forget amaurosis fugax. ( 21690157 )
2011
35
Sleep-induced amaurosis fugax. ( 21723066 )
2011
36
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. ( 20934672 )
2010
37
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. ( 20434591 )
2010
38
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. ( 21302720 )
2010
39
Diagnosing amaurosis fugax with emergency ultrasound. ( 20015107 )
2010
40
Jugular venous reflux affects ocular venous system in transient monocular blindness. ( 19955735 )
2010
41
From amaurosis fugax to asymptomatic bithalamic infarct. ( 19252800 )
2009
42
Optic neuritis presenting with amaurosis fugax. ( 19727900 )
2009
43
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene. ( 19507653 )
2009
44
Time to carotid endarterectomy. Don't forget amaurosis fugax. ( 19564188 )
2009
45
Transient monocular blindness precipitated by sexual intercourse. ( 18658172 )
2009
46
Common carotid artery stenosis and amaurosis fugax. ( 18190813 )
2008
47
Recurrent transient monocular blindness with ophthalmic artery stenosis. ( 18230884 )
2008
48
Reflux of jugular and retrobulbar venous flow in transient monocular blindness. ( 18306412 )
2008
49
Novel mouse model of monocular amaurosis fugax. ( 17975099 )
2007
50
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. ( 17456620 )
2007

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 F5 SERPINE1
2
Show member pathways
11.45 MMP8 MMP9 SERPINE1
3 11.35 MMP9 SERPINE1
4
Show member pathways
11.15 MMP8 MMP9
5 10.74 MMP9 SERPINE1

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 F5 MMP8 MMP9 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.16 F5 SERPINE1
3 tertiary granule lumen GO:1904724 8.96 MMP8 MMP9
4 collagen-containing extracellular matrix GO:0062023 8.8 MMP8 MMP9 SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.4 F5 SERPINE1
2 extracellular matrix disassembly GO:0022617 9.37 MMP8 MMP9
3 blood circulation GO:0008015 9.32 F5 MTHFR
4 collagen catabolic process GO:0030574 9.26 MMP8 MMP9
5 positive regulation of DNA binding GO:0043388 9.16 MMP8 MMP9
6 endodermal cell differentiation GO:0035987 8.96 MMP8 MMP9
7 regulation of neuroinflammatory response GO:0150077 8.62 MMP8 MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP8 MMP9
2 endopeptidase activity GO:0004175 8.62 MMP8 MMP9

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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