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MCID: AMB001
MIFTS: 48

Amebiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Amebiasis

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MalaCards integrated aliases for Amebiasis:

Name: Amebiasis 12 77 54 45 15 17 74
Amoebiasis Due to Entamoeba Histolytica 54 60
Chronic Intestinal Amebiasis 12 74
Entamoebiasis 12 74
Amoebic Dysentery Due to Entamoeba Histolytica 54
Intestinal Amebiasis 54
Amoebic Enteritis 74
Amebic Dysentery 54
Amebic Colitis 74
Amoebiasis 12

Characteristics:

Orphanet epidemiological data:

60
amoebiasis due to entamoeba histolytica
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9181
ICD9CM 36 006 006.9
MeSH 45 D000562
NCIt 51 C84551
ICD10 34 A06 A06.9
MESH via Orphanet 46 C531613
UMLS via Orphanet 75 C2930799
Orphanet 60 ORPHA67
Sources

Summaries for Amebiasis

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CDC : 3 Amebiasis is a disease caused by the parasite Entamoeba histolytica. It can affect anyone, although it is more common in people who live in tropical areas with poor sanitary conditions. Diagnosis can be difficult because other parasites can look very similar to E. histolytica when seen under a microscope. Infected people do not always become sick. If your doctor determines that you are infected and need treatment, medication is available.

MalaCards based summary : Amebiasis, also known as amoebiasis due to entamoeba histolytica, is related to leukocyte adhesion deficiency, type i and amoebiasis due to free-living amoebae. An important gene associated with Amebiasis is IL17A (Interleukin 17A), and among its related pathways/superpathways are Visual Cycle in Retinal Rods and Development_Thrombopoetin signaling via JAK-STAT pathway. The drugs Sodium Citrate and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and colon.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

Wikipedia : 77 Amoebiasis, also known amoebic dysentery, is an infection caused by any of the amobae of the Entamoeba... more...

Sources

Related Diseases for Amebiasis

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Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 leukocyte adhesion deficiency, type i 30.2 ICAM1 IL17A
2 amoebiasis due to free-living amoebae 12.3
3 colitis 10.4
4 autoimmune enteropathy 10.3 ICAM1 IL17A
5 ocular toxoplasmosis 10.3 CD79A IL17A
6 hypersensitivity reaction type iii disease 10.2 CD79A ICAM1
7 dysentery 10.2
8 giardiasis 10.2
9 appendicitis 10.2
10 henoch-schoenlein purpura 10.2 CD79A ICAM1
11 extrinsic cardiomyopathy 10.2 ICAM1 IL17A
12 ulcerative colitis 10.1
13 shigellosis 10.1
14 autoimmune uveitis 10.1 ICAM1 IL17A
15 epidemic typhus 10.1
16 dermatitis 10.1
17 exfoliative dermatitis 10.1
18 trichuriasis 10.1
19 solitary osseous plasmacytoma 10.1 CD79A IGLL5
20 arthritis 10.1
21 acquired immunodeficiency syndrome 10.1
22 skin disease 10.0 CD79A ICAM1 IL17A KRT9
23 rheumatoid arthritis 10.0
24 malaria 10.0
25 inflammatory bowel disease 10.0
26 trypanosomiasis 10.0
27 diarrhea 10.0
28 pleurisy 10.0
29 intestinal disease 10.0
30 intestinal obstruction 10.0
31 membranoproliferative glomerulonephritis 10.0 CD79A ICAM1
32 neutropenia 9.9
33 schistosomiasis 9.9
34 urticaria 9.9
35 squamous cell carcinoma 9.9
36 trichomoniasis 9.9
37 adenocarcinoma 9.9
38 purpura 9.9
39 syphilis 9.9
40 toxoplasmosis 9.9
41 pelvic organ prolapse 9.9
42 suppressor of tumorigenicity 3 9.9
43 diabetes mellitus 9.9
44 tungiasis 9.9
45 intestinal schistosomiasis 9.9
46 cysticercosis 9.9
47 adrenal cortical hypofunction 9.9
48 respiratory failure 9.9
49 pyelonephritis 9.9
50 cardiac tamponade 9.9

Graphical network of the top 20 diseases related to Amebiasis:



Diseases related to Amebiasis
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Symptoms & Phenotypes for Amebiasis

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Drugs & Therapeutics for Amebiasis

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Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 4 68-04-2
2
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
3
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
4
Metronidazole Approved Phase 4 443-48-1 4173
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
6 Anthelmintics Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antiparasitic Agents Phase 4,Phase 3
9 Antimitotic Agents Phase 4
10 Citrate Phase 4
11 DMP 777 Phase 4 157341-41-8
12 Piperazine citrate Phase 4
13 Antiprotozoal Agents Phase 4,Phase 3
14 Anti-Bacterial Agents Phase 4
15
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
16
Polihexanide Approved, Investigational Phase 3,Phase 1 28757-47-3
17
Propamidine Experimental, Investigational Phase 3 104-32-5
18 Ophthalmic Solutions Phase 3,Phase 1
19 Biguanides Phase 3,Phase 1
20 Hypoglycemic Agents Phase 3,Phase 1
21 Disinfectants Phase 3,Phase 2,Phase 1
22 Pharmaceutical Solutions Phase 3,Phase 1
23 Anti-Infective Agents, Local Phase 3,Phase 2
24 Dibrompropamidine Phase 3
25
Auranofin Approved, Investigational Phase 2,Phase 1 34031-32-8 6918453 6333901
26
Povidone-iodine Approved Phase 2 25655-41-8
27
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
28
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
29
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
30
Iodine Approved, Investigational Phase 2 7553-56-2 807
31
Povidone Approved Phase 2 9003-39-8
32
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
33
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
34
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
35 Antirheumatic Agents Phase 2,Phase 1
36 Gastrointestinal Agents Phase 2
37 Protective Agents Phase 2
38 glucocorticoids Phase 2
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
40 Neuroprotective Agents Phase 2
41 Blood Substitutes Phase 2
42 Dermatologic Agents Phase 2
43 Antineoplastic Agents, Hormonal Phase 2
44 Hormone Antagonists Phase 2
45 Micronutrients Phase 2
46 Antiemetics Phase 2
47 Methylprednisolone Acetate Phase 2
48 Prednisolone acetate Phase 2
49 Chlorhexidine gluconate Phase 2
50 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4 Mebendazole;Quinfamide;Placebo
2 Is it Effective to Treat Patients With Blastocystis Hominis Infection? Active, not recruiting NCT01521403 Phase 4 Metronidazole;Placebo
3 Study of Nitazoxanide in the Treatment of Amebiasis in Children Completed NCT00366730 Phase 3 Nitazoxanide
4 Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents Completed NCT00366236 Phase 3 Nitazoxanide
5 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
6 Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
7 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
8 Auranofin PK Following Oral Dose Administration Completed NCT02089048 Phase 1 Auranofin
9 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
10 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
11 Field Studies of Amebiasis in Bangladesh Completed NCT02734264
12 Ameparomo Capsules 250 mg Drug Use Investigation Completed NCT02680665
13 Anaemetro I.V. Infusion 500mg Drug Use Investigation Completed NCT03491228
14 Prognosis of Failure Treatment of Amebic Liver Abscess Completed NCT00641992
15 Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
16 Primary Cecal Pathologies Presenting as Acute Abdomen Completed NCT03262025
17 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
18 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
19 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable
20 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: amebiasis

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Genetic Tests for Amebiasis

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Anatomical Context for Amebiasis

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MalaCards organs/tissues related to Amebiasis:

42
Liver, Testes, Colon, Lung, Brain, Eye, Skin
Sources

Publications for Amebiasis

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Articles related to Amebiasis:

(show top 50) (show all 1176)
# Title Authors Year
1
Learning from the research on amebiasis and gut microbiome: Is stimulation by gut flora essential for effective neutrophil mediated protection from external pathogens? ( 30252579 )
2019
2
Vorinostat, a possible alternative to Metronidazole for the treatment of amebiasis caused by Entamoeba histolytica. ( 30744531 )
2019
3
Amebiasis, a rare cause of acute appendicitis. ( 30891179 )
2019
4
Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis. ( 29739480 )
2018
5
Serodiagnosis of Extraintestinal Amebiasis: Retrospective Evaluation of the Diagnostic Performance of the BordierAr ELISA Kit. ( 29529853 )
2018
6
Chronic urticaria revealing amebiasis. ( 29908957 )
2018
7
A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis. ( 30046644 )
2018
8
The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man. ( 30049805 )
2018
9
Closing The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man. ( 30049806 )
2018
10
Colonic perforation due to amebiasis, a rare and lethal complication. ( 30443315 )
2018
11
Case Report: Endemic Amebiasis in Australia: Implications for Residents, Travelers, and Clinicians. ( 28719303 )
2017
12
A case of amebiasis with negative serologic markers that caused intra-abdominal abscess. ( 28527648 )
2017
13
IL-17A contributes to reducing IFN-I^/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis. ( 28927906 )
2017
14
First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections. ( 28243230 )
2017
15
Gene migration for re-emerging amebiasis in Iran's northwest-Iraq borders: a microevolutionary scale for reflecting epidemiological drift of Entamoeba histolytica metapopulations. ( 27761718 )
2017
16
Penile amebiasis mimicking penile squamous cell carcinoma. ( 28083900 )
2017
17
Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica. ( 27242782 )
2016
18
Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution. ( 27795472 )
2016
19
Modulation of innate immune response by the vagus nerve in experimental hepatic amebiasis in rats. ( 27466057 )
2016
20
Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy. ( 27688666 )
2016
21
Prevalence of Entamoeba spp. in Stool Samples of Patients with Amebiasis Suspect by Native-Lugol and ELISA. ( 27594283 )
2016
22
Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis. ( 27764256 )
2016
23
Vaginal Amebiasis Mimicking Cervical Cancer. ( 27746453 )
2016
24
A Strong Correlation between the Annual Incidence of Amebiasis and Homosexual Human Immunodeficiency Virus Type Infection in Men. ( 26743150 )
2016
25
Entamoeba histolytica: Overexpression of the gal/galnac lectin, ehcp2 and ehcp5 genes in an in vivo model of amebiasis. ( 27616150 )
2016
26
Epidemiology of Domestically Acquired Amebiasis in Japan, 2000-2013. ( 26976888 )
2016
27
Primary Pulmonary Amebiasis Complicated with Multicystic Empyema. ( 27478673 )
2016
28
Neurologic amebiasis caused by Balamuthia mandrillaris in an Indian flying fox (Pteropus giganteus). ( 26762405 )
2016
29
Prevalence of amebiasis in inflammatory bowel disease in University Clinical Hospital Mostar. ( 27652159 )
2016
30
Amebic lung abscess with coexisting lung adenocarcinoma: a unusual case of amebiasis. ( 25550881 )
2014
31
Tropical dermatology: cutaneous larva migrans, gnathostomiasis, cutaneous amebiasis and trombiculiasis. ( 25577853 )
2014
32
Noninvasive intestinal amebiasis: Entamoeba histolytica colonization without invasion. ( 25101557 )
2014
33
Diffuse Hepatic Amebiasis Detected by FDG PET/CT. ( 25275416 )
2014
34
Subjective adverse reactions to metronidazole in patients with amebiasis. ( 24929036 )
2014
35
Laboratory diagnosis of amebiasis in a sample of students from southeastern Brazil and a comparison of microscopy with enzyme-linked immunosorbent assay for screening of infections with Entamoeba sp. ( 24603737 )
2014
36
Asymptomatic intestinal amebiasis in Japanese HIV-1-infected individuals. ( 25048374 )
2014
37
Amebiasis presenting as acute appendicitis: Report of a case and review of Japanese literature. ( 25460473 )
2014
38
Tissue destruction in amebiasis: chew on it. ( 25105188 )
2014
39
Colonoscopic diagnosis of amebiasis: a case series and systematic review. ( 25346004 )
2014
40
Host immune response to intestinal amebiasis. ( 23990778 )
2013
41
Intestinal amebiasis: a concerning cause of acute gastroenteritis among hospitalized lebanese children. ( 24404551 )
2013
42
Case report: Cutaneous amebiasis: the importance of molecular diagnosis of an emerging parasitic disease. ( 23208883 )
2013
43
Intestinal amebiasis in a group of patients with ulcerative colitis: influence on clinical course of the disease. ( 23678829 )
2013
44
An integrated microfluidic device for rapid serodiagnosis of amebiasis. ( 24403984 )
2013
45
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. ( 23775017 )
2013
46
Efficacy and safety of paromomycin for treating amebiasis in Japan. ( 23850836 )
2013
47
Unde venis? Amebiasis presenting as appendicitis. ( 24902389 )
2013
48
Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study. ( 23243179 )
2013
49
Cutaneous amebiasis: 50 years of experience. ( 23409482 )
2012
50
Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis. ( 22318340 )
2012
Sources

Variations for Amebiasis

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Expression for Amebiasis

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Search GEO for disease gene expression data for Amebiasis.
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Pathways for Amebiasis

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Pathways related to Amebiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Visual Cycle in Retinal Rods 65
10.77 CABP1 CABP2 CABP5
2
Development_Thrombopoetin signaling via JAK-STAT pathway 23
10.49 CABP1 CABP2 CABP5
Sources

GO Terms for Amebiasis

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Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD79A ICAM1 IGLL5 IL17A

Biological processes related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 8.8 CABP2 CHRNA9 ICAM1

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 CD79A CHRNA9 ICAM1
2 microfilament motor activity GO:0000146 8.96 MYO1B MYO1C
3 actin-dependent ATPase activity GO:0030898 8.62 MYO1B MYO1C
Sources

Sources for Amebiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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