MCID: AMB001
MIFTS: 56

Amebiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Amebiasis

MalaCards integrated aliases for Amebiasis:

Name: Amebiasis 12 73 20 44 15 17 70
Amoebiasis Due to Entamoeba Histolytica 20 58
Chronic Intestinal Amebiasis 12 70
Entamoebiasis 12 70
Amoebiasis 12 32
Amoebic Dysentery Due to Entamoeba Histolytica 20
Intestinal Amebiasis 20
Amoebic Enteritis 70
Amebic Dysentery 20
Amebic Colitis 70

Characteristics:

Orphanet epidemiological data:

58
amoebiasis due to entamoeba histolytica
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9181
ICD9CM 34 006
MeSH 44 D000562
NCIt 50 C84551
SNOMED-CT 67 387754006
ICD10 32 A06 A06.9
MESH via Orphanet 45 C531613
UMLS via Orphanet 71 C2930799
Orphanet 58 ORPHA67
UMLS 70 C0002438 C0002440 C0013370 more

Summaries for Amebiasis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

MalaCards based summary : Amebiasis, also known as amoebiasis due to entamoeba histolytica, is related to dysentery and giardiasis. An important gene associated with Amebiasis is IL17A (Interleukin 17A), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Mebendazole and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related phenotypes are abdominal pain and chest pain

Wikipedia : 73 Amoebiasis, also known amoebic dysentery, is an infection caused by any of the amoebae of the Entamoeba... more...

Related Diseases for Amebiasis

Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 602)
# Related Disease Score Top Affiliating Genes
1 dysentery 31.2 TNF IL1B CXCL8 CPA5 CD4
2 giardiasis 31.1 IL17A CD79A CD4
3 appendicitis 30.9 TNF IL1B IL17A CXCL8
4 peritonitis 30.7 TNF IL4 IL1B ICAM1 CXCL8
5 colitis 30.6 TNF IL4 IL1B IL17A CXCL8 CD4
6 shigellosis 30.6 TNF IL1B CXCL8
7 schistosomiasis 30.6 TNF IL4 IL17A
8 pericarditis 30.5 TNF IL1B CXCL8
9 gastritis 30.5 TNF IL1B IL17A CXCL8
10 ulcerative colitis 30.5 TNF IL4 IL1B IL17A ICAM1 CXCL8
11 pleurisy 30.5 TNF ICAM1 CXCL8
12 toxoplasmosis 30.5 TNF IL4 IL1B CD79A
13 cholera 30.4 TNF IL4 IL1B CD79A
14 syphilis 30.4 TNF IL17A FN1 CD79A CD4
15 leishmaniasis 30.4 TNF IL4 IL1B IL17A
16 trichomoniasis 30.4 TNF IL1B CXCL8 CD4
17 plasmodium falciparum malaria 30.3 TNF IL4 ICAM1
18 acquired immunodeficiency syndrome 30.3 TNF IL1B ICAM1 CD79A CD4
19 vasculitis 30.3 TNF IL17A ICAM1 CD79A
20 urticaria 30.3 TNF IL4 CXCL8 CD4
21 strongyloidiasis 30.2 IL4 CD79A CD4
22 duodenal ulcer 30.2 TNF IL1B CXCL8
23 allergic disease 30.2 TNF IL4 IL1B CXCL8
24 purpura 30.2 TNF IL4 CD79A
25 immune deficiency disease 30.2 TNF IL4 IL1B IL17A FN1 CD79A
26 exanthem 30.1 TNF IL1B CXCL8 CD4
27 trypanosomiasis 30.1 TNF IL4 IL1B ICAM1 CXCL8
28 choroiditis 30.1 TNF IL17A CD4
29 clonorchiasis 30.1 TNF CXCL8 CD79A
30 pyoderma 30.1 TNF IL1B CXCL8
31 gastroenteritis 30.1 TNF IL4 IL1B CXCL8
32 parasitic protozoa infectious disease 30.1 TNF IL4 IL1B IL17A ICAM1 CXCL8
33 trichinosis 30.1 IL4 IL17A CD4
34 erythema nodosum 30.1 TNF IL1B ICAM1 CXCL8
35 plague 30.1 TNF IL1B CD4
36 salmonellosis 30.1 TNF IL1B IL17A CXCL8 CD4
37 yellow fever 30.0 IL4 IL1B IL17A
38 endocarditis 30.0 TNF IL17A CXCL8
39 pyelonephritis 30.0 TNF IL1B CXCL8
40 mucocutaneous leishmaniasis 30.0 TNF IL4 CD4
41 peptic ulcer disease 30.0 TNF IL1B CXCL8
42 taeniasis 30.0 TNF IL4 CD4
43 disease by infectious agent 30.0 TNF MIR144 IL4 IL1B IL17A CD4
44 pulmonary edema 30.0 TNF IL1B ICAM1 CXCL8
45 intestinal schistosomiasis 30.0 TNF IL4 IL17A CD4
46 cysticercosis 30.0 IL4 IL1B CD4
47 glomerulonephritis 30.0 IL1B ICAM1 FN1 CD79A
48 alcoholic liver cirrhosis 30.0 TNF IL1B CXCL8
49 brucellosis 30.0 TNF IL4 IL17A CXCL8
50 dermatitis 29.9 TNF IL4 IL1B IL17A ICAM1 CXCL8

Graphical network of the top 20 diseases related to Amebiasis:



Diseases related to Amebiasis

Symptoms & Phenotypes for Amebiasis

Human phenotypes related to Amebiasis:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
2 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
3 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
4 gastrointestinal dysmotility 58 31 occasional (7.5%) Occasional (29-5%) HP:0002579
5 protracted diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0004385
6 bloody diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0025085
7 fever 58 31 very rare (1%) Very rare (<4-1%) HP:0001945
8 anemia 58 31 very rare (1%) Very rare (<4-1%) HP:0001903
9 congestive heart failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001635
10 elevated hepatic transaminase 58 31 very rare (1%) Very rare (<4-1%) HP:0002910
11 dyspnea 58 31 very rare (1%) Very rare (<4-1%) HP:0002094
12 hemoptysis 58 31 very rare (1%) Very rare (<4-1%) HP:0002105
13 cough 58 31 very rare (1%) Very rare (<4-1%) HP:0012735
14 liver abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0100523
15 intestinal obstruction 58 31 very rare (1%) Very rare (<4-1%) HP:0005214
16 hypoalbuminemia 58 31 very rare (1%) Very rare (<4-1%) HP:0003073
17 leukocytosis 58 31 very rare (1%) Very rare (<4-1%) HP:0001974
18 deep venous thrombosis 58 31 very rare (1%) Very rare (<4-1%) HP:0002625
19 elevated alkaline phosphatase 58 31 very rare (1%) Very rare (<4-1%) HP:0003155
20 acute colitis 58 31 very rare (1%) Very rare (<4-1%) HP:0100282
21 lung abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0025044
22 pleural empyema 58 31 very rare (1%) Very rare (<4-1%) HP:0011919
23 constrictive pericarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0002563
24 pleural effusion 58 Very rare (<4-1%)
25 diarrhea 58 Occasional (29-5%)
26 abnormal pericardium morphology 58 Very rare (<4-1%)
27 abnormal sputum 58 Very rare (<4-1%)

MGI Mouse Phenotypes related to Amebiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 AIG1 CD4 CD79A FN1 ICAM1 IGLL5
2 immune system MP:0005387 9.77 AIG1 CD4 CD79A FN1 ICAM1 IGLL5
3 no phenotypic analysis MP:0003012 9.17 CD4 CD79A IL17A IL4 LEPR MYO1C

Drugs & Therapeutics for Amebiasis

Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
2
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
3
Sodium citrate Approved, Investigational Phase 4 68-04-2
4
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
5 Tubulin Modulators Phase 4
6 Antiparasitic Agents Phase 4
7 Citrate Phase 4
8 Antimitotic Agents Phase 4
9 DMP 777 Phase 4 157341-41-8
10 Anthelmintics Phase 4
11 Anti-Infective Agents Phase 4
12 Piperazine citrate Phase 4
13
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
14
Auranofin Approved, Investigational Phase 1 34031-32-8 6333901 6918453
15 Antirheumatic Agents Phase 1
16
Formaldehyde Approved, Vet_approved 50-00-0 712
17 Ether
18 Disinfectants
19 Cola
20 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4 Mebendazole;Quinfamide;Placebo
2 Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Tablets in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Adults and Adolescents Completed NCT00366236 Phase 3 Nitazoxanide
3 Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Suspension in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Children Completed NCT00366730 Phase 3 Nitazoxanide
4 An Open Label, Multiple Dose Study to Evaluate the Pharmacokinetics of Auranofin Following Oral Dose Administration for 7 Days to Healthy Subjects Completed NCT02089048 Phase 1 Auranofin
5 AMEPAROMO CAPSULES 250 MG DRUG USE INVESTIGATION Completed NCT02680665
6 Field Studies of Human Immunity to Amebiasis in Bangladesh: A Prospective Study of Children Ages 0-17 Years Completed NCT02734264
7 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
8 Primary Cecal Pathologies Presenting as Acute Abdomen and Critical Appraisal of Their Current Management Strategies Completed NCT03262025
9 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Chloroquine
Chloroquine hydrochloride
chloroquine phosphate
Emetine
Emetine Hydrochloride
Iodoquinol
Metronidazole
Metronidazole Hydrochloride
METRONIDAZOLE PWDR

Cochrane evidence based reviews: amebiasis

Genetic Tests for Amebiasis

Anatomical Context for Amebiasis

MalaCards organs/tissues related to Amebiasis:

40
Lung, Colon, Liver, Brain, Skin, Heart, Bone Marrow

Publications for Amebiasis

Articles related to Amebiasis:

(show top 50) (show all 3540)
# Title Authors PMID Year
1
Human secretory immunoglobulin A anti-Entamoeba histolytica antibodies inhibit adherence of amebae to MDCK cells. 54 61
8300242 1994
2
Diagnosis of intestinal amebiasis using salivary IgA antibody detection. 61 54
2230266 1990
3
[Fecal and serum anti-amebic antibodies in acute intestinal amebiasis]. 61 54
2136492 1990
4
An encapsulated bulky abdominal abscess due to amoeba. 61
33428067 2021
5
Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E. 61
33711336 2021
6
Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt. 61
33798117 2021
7
Entamoeba histolytica-Gut Microbiota Interaction: More Than Meets the Eye. 61
33809056 2021
8
Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator. 61
33688012 2021
9
Development of diffractive optics technology-based immunoassay protocol and its application in the detection of Entamoeba histolytica infections. 61
33689809 2021
10
Low molecular weight protein tyrosine phosphatase (LMW-PTP2) protein can potentially modulate virulence of the parasite Entamoeba histolytica. 61
33428948 2021
11
Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and potentially in differentiation of the human enteric protozoan parasite Entamoeba histolytica. 61
33592076 2021
12
Review of zoonotic amebiasis: Epidemiology, clinical signs, diagnosis, treatment, prevention and control. 61
33676155 2021
13
Host Protective Mechanisms to Intestinal Amebiasis. 61
33502317 2021
14
Gastrointestinal entamoebiasis in captive anurans in North America. 61
33570044 2021
15
Antibiomania: A Rare Case of Metronidazole-Induced Mania. 61
33409111 2021
16
Clinical features of amoebic appendicitis in children: A study of 23 cases. 61
33461743 2021
17
Spectrum of CT findings in amebic colitis. 61
33462730 2021
18
Surgical management of cerebral peduncle neurocysticercosis: A case report of decision making in a resource-restricted environment. 61
33310464 2021
19
Rab7D small GTPase is involved in phago-, trogocytosis and cytoskeletal reorganization in the enteric protozoan Entamoeba histolytica. 61
32975360 2021
20
Secondary infection of amoeba and typhoid fever in severe malnourished pediatric patient with Type I choledocal cyst: a case report. 61
33391767 2020
21
Ascariasis, Amebiasis and Giardiasis in Mexican children: distribution and geographical, environmental and socioeconomic risk factors. 61
33177788 2020
22
[Necrotizing amebian colitis, case report]. 61
33399810 2020
23
Signals and signal transduction pathways in Entamoeba histolytica during the life cycle and when interacting with bacteria or human cells. 61
33249684 2020
24
Pulmonary Thromboembolism: A Rare Vascular Complication of Amebic Liver Abscess. 61
33178525 2020
25
Myocarditis Associated With Enteric Amebiasis in an Adolescent. 61
32853078 2020
26
Case report: multiple and atypical amoebic cerebral abscesses resistant to treatment. 61
32928130 2020
27
Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives. 61
32778548 2020
28
A rare hepatic mass in an Italian resident. 61
32917150 2020
29
A lysosomal hydrolase receptor, CPBF2, is associated with motility and invasion of the enteric protozoan parasite Entamoeba histolytica. 61
32707151 2020
30
Role of inflammasomes in innate host defense against Entamoeba histolytica. 61
32498132 2020
31
Insights into amebiasis using a human 3D-intestinal model. 61
32175652 2020
32
Gut microbiome communication with bone marrow regulates susceptibility to amebiasis. 61
32369444 2020
33
Prevalence, molecular epidemiology and zoonotic risk of Entamoeba spp. from experimental macaques in Yunnan Province, southwestern China. 61
32617726 2020
34
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. 61
32651360 2020
35
Cecal amebiasis mimicking inflammatory bowel disease. 61
32475192 2020
36
Antiprotozoal Activity against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth. 61
32466359 2020
37
EhRab21 associates with the Golgi apparatus in Entamoeba histolytica. 61
32219551 2020
38
Fulminant amebic colitis: An unusual postoperative complication of intraabdominal malignancy. 61
32134005 2020
39
Secreted Phosphoprotein 1 (SPP1) and Fibronectin 1 (FN1) Are Associated with Progression and Prognosis of Esophageal Cancer as Identified by Integrated Expression Profiles Analysis. 61
32208405 2020
40
Stress-responsive Entamoeba topoisomerase II: a potential antiamoebic target. 61
31724164 2020
41
Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses. 61
31772322 2020
42
Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity. 61
32000049 2020
43
Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants. 61
31914335 2020
44
Epidemiology of Parasitic Infections in the West Bank and Gaza Strip, Palestine. 61
31769396 2020
45
Seroprevalence of Entamoeba histolytica at a voluntary counselling and testing centre in Tokyo: a cross-sectional study. 61
32102805 2020
46
Liver abscess in «anchovy paste»; amebiasis alert. 61
32057357 2020
47
Vorinostat, a possible alternative to metronidazole for the treatment of amebiasis caused by Entamoeba histolytica. 61
30744531 2020
48
Acetylcholine Upregulates Entamoeba histolytica Virulence Factors, Enhancing Parasite Pathogenicity in Experimental Liver Amebiasis. 61
33585267 2020
49
Identification of <i>Entamoeba histolytica</i> in Patients with Suspected Amebiasis in Jordan Using PCR-based Assays. 61
31944076 2020
50
Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis. 61
33718258 2020

Variations for Amebiasis

Expression for Amebiasis

Search GEO for disease gene expression data for Amebiasis.

Pathways for Amebiasis

Pathways related to Amebiasis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TNF MYO1C MYO1B IL4 IL1B IL17A
2
Show member pathways
13.33 TNF IL4 IL1B IL17A ICAM1 FN1
3
Show member pathways
13.28 TNF MYO1C MYO1B IL4 IL1B IL17A
4
Show member pathways
12.78 TNF IL4 IL1B IL17A ICAM1 CXCL8
5
Show member pathways
12.72 TNF MYO1C MYO1B IL1B CXCL8
6
Show member pathways
12.6 TNF IL4 IL1B IL17A CD4
7
Show member pathways
12.59 TNF IL4 IL1B IL17A CD4
8
Show member pathways
12.57 TNF IL1B IL17A FN1 CD4
9 12.55 TNF IL4 IL1B IL17A CD79A
10
Show member pathways
12.31 TNF IL4 IL1B ICAM1
11
Show member pathways
12.31 TNF IL4 IL1B IL17A CXCL8
12
Show member pathways
12.25 TNF IL4 IL1B IL17A CXCL8
13
Show member pathways
12.13 TNF IL4 IL1B FN1 CXCL8
14 11.99 TNF IL1B FN1 CXCL8 CD4
15 11.98 TNF IL4 CD79A CD4
16 11.92 TNF IL1B ICAM1 CXCL8
17 11.91 TNF IL1B FN1 CXCL8
18 11.91 TNF IL4 IL1B ICAM1 CXCL8
19 11.89 TNF IL4 IL1B CD4
20
Show member pathways
11.84 IL4 IL1B IL17A CD4
21 11.8 TNF IL1B ICAM1 FN1 CXCL8
22 11.78 IL4 ICAM1 CXCL8
23 11.74 TNF IL1B CXCL8
24
Show member pathways
11.74 TNF IL4 CXCL8
25
Show member pathways
11.74 TNF IL1B IL17A CD4
26 11.72 TNF IL1B CD4
27 11.69 TNF IL1B IL17A ICAM1 CXCL8
28 11.67 TNF IL4 ICAM1
29
Show member pathways
11.64 TNF IL1B ICAM1 CXCL8
30 11.62 TNF IL4 IL1B CXCL8
31 11.6 TNF IL1B CXCL8
32 11.52 TNF ICAM1 FN1
33 11.48 TNF IL1B ICAM1 CXCL8
34 11.47 ICAM1 FN1 CXCL8
35 11.46 TNF IL4 IL1B IL17A CD4
36 11.38 TNF IL1B ICAM1
37 11.22 TNF IL4 IL1B IL17A ICAM1 FN1
38 11.17 TNF IL4 IL1B IL17A
39 11.04 TNF IL4 IL1B ICAM1 CXCL8
40 11.02 TNF FN1 CXCL8
41 11.02 TNF IL4 IL1B CD4
42 11.01 TNF IL4 IL1B IL17A FN1 CXCL8
43 10.93 TNF IL1B ICAM1
44 10.77 IL4 IL1B

GO Terms for Amebiasis

Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TNF LEPR IL4 IL1B IL17A IGLL5
2 extracellular space GO:0005615 9.81 TNF MIR144 IL4 IL1B IL17A ICAM1
3 membrane raft GO:0045121 9.35 TNF MYO1C ICAM1 CD79A CD4
4 external side of plasma membrane GO:0009897 9.17 TNF LEPR IL17A IGLL5 ICAM1 CD79A

Biological processes related to Amebiasis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.83 TNF LEPR IL1B CD4
2 cellular response to lipopolysaccharide GO:0071222 9.76 TNF IL1B ICAM1 CXCL8
3 cellular response to interleukin-1 GO:0071347 9.74 IL17A ICAM1 CXCL8
4 positive regulation of gene expression GO:0010628 9.73 TNF MIR144 IL4 IL1B FN1 CXCL8
5 positive regulation of T cell proliferation GO:0042102 9.71 IL4 IL1B CD4
6 positive regulation of interleukin-1 beta production GO:0032731 9.67 TNF MIR144 IL17A
7 immune response GO:0006955 9.63 TNF IL4 IL1B IL17A CXCL8 CD4
8 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL1B
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 TNF IL1B ICAM1
10 regulation of establishment of endothelial barrier GO:1903140 9.56 TNF IL1B
11 positive regulation of cell adhesion molecule production GO:0060355 9.55 MIR144 IL1B
12 vascular endothelial growth factor production GO:0010573 9.51 TNF IL1B
13 positive regulation of mononuclear cell migration GO:0071677 9.48 TNF IL4
14 positive regulation of fever generation GO:0031622 9.43 TNF IL1B
15 sequestering of triglyceride GO:0030730 9.37 TNF IL1B
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IL1B
17 cytokine-mediated signaling pathway GO:0019221 9.28 TNF LEPR IL4 IL1B IL17A ICAM1
18 positive regulation of interleukin-6 production GO:0032755 9.26 TNF MIR144 IL1B IL17A

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.26 LEPR ICAM1 CD79A CD4
2 cytokine activity GO:0005125 9.02 TNF IL4 IL1B IL17A CXCL8

Sources for Amebiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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