Amebiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

MalaCards based summary: Amebiasis, also known as amoebiasis, is related to dysentery and giardiasis. An important gene associated with Amebiasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium citrate and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and brain, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia: ⁷⁵ Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba... more...

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Related Diseases for Amebiasis

Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)

#	Related Disease	Score	Top Affiliating Genes
1	dysentery	31.2	TNF IL6 IL1B CXCL8 CD4 ALB
2	giardiasis	31.2	IL17A CD79A CD4 ALB
3	schistosomiasis	30.9	TNF IL17A ALB
4	inflammatory bowel disease 1	30.8	TNF TLR2 IL6 IL1B IL17A
5	appendicitis	30.7	TNF IL6 IL1B IL17A CXCL8 ALB
6	pleural empyema	30.7	IL6 CD79A CD4 ALB
7	diarrhea	30.7	TNF IL6 IL1B CXCL8 ALB
8	bowel dysfunction	30.7	TNF IL6 IL1B ALB
9	ulcerative colitis	30.6	TNF TLR2 IL6 IL1B IL17A CXCL8
10	pericarditis	30.6	TNF IL6 IL1B CXCL8
11	cholera	30.6	TNF IL6 IL1B CXCL8 CD79A
12	toxoplasmosis	30.6	TNF IL6 IL1B IL17A CD79A
13	gastritis	30.5	TNF IL6 IL1B IL17A CXCL8
14	colitis	30.5	TNF TLR2 IL6 IL1B IL17A CXCL8
15	cryptosporidiosis	30.5	TNF CD79A CD4
16	peritonitis	30.5	TNF TLR2 IL6 IL1B IL17A ICAM1
17	pleurisy	30.5	TNF IL1B CXCL8
18	echinococcosis	30.5	TNF TLR2 IL6 IL17A
19	plasmodium falciparum malaria	30.4	TNF IL6 ICAM1
20	trichomoniasis	30.4	TNF IL6 IL1B CXCL8 CD4
21	encephalitis	30.4	TNF TLR2 IL6 IL1B CXCL8
22	lung abscess	30.4	TNF IL6 IL1B CD4 ALB
23	intestinal perforation	30.4	TNF IL6 CD4 ALB
24	neurotic disorder	30.4	TNF IL6 IL1B
25	acute diarrhea	30.4	CXCL8 CD4 ALB
26	filarial elephantiasis	30.4	TNF TLR2 CD4
27	acquired immunodeficiency syndrome	30.3	TNF IL6 IL1B ICAM1 CD79A CD4
28	syphilis	30.3	TNF TLR2 IL17A FN1 CD79A CD4
29	urticaria	30.3	TNF IL6 IL1B IL17A CXCL8 CD4
30	duodenal ulcer	30.3	TNF IL6 IL1B CXCL8
31	pemphigus	30.3	TNF IL6 IL17A CD79A
32	proliferative glomerulonephritis	30.3	CFHR2 CD79A ALB
33	typhoid fever	30.3	TNF IL6 IL1B ALB
34	pericardial effusion	30.2	TNF IL6 CD4 ALB
35	inflammatory bowel disease	30.2	TNF TLR2 IL6 IL1B IL17A ICAM1
36	leishmaniasis	30.2	TNF TLR2 IL6 IL1B IL17A CXCL8
37	intestinal schistosomiasis	30.2	TNF IL17A CD4
38	immune deficiency disease	30.2	TNF TLR2 IL6 IL1B IL17A FN1
39	clonorchiasis	30.2	TNF CXCL8 CD79A
40	pyoderma gangrenosum	30.2	TNF IL1B CXCL8
41	viral hepatitis	30.2	TLR2 IL6 ICAM1 ALB
42	polyarteritis nodosa	30.2	TNF IL6 ICAM1
43	choroiditis	30.2	TNF IL17A CD4
44	granulomatous hepatitis	30.2	TNF CD4 ALB
45	pyoderma	30.2	TNF IL1B IL17A CXCL8
46	pneumocystosis	30.2	TNF IL6 IL17A CD4 ALB
47	miliary tuberculosis	30.2	TNF CD4 ALB
48	aspergillosis	30.2	TNF TLR2 IL6 IL1B CXCL8
49	pulmonary tuberculosis	30.2	TNF TLR2 IL6 IL1B ALB
50	parotitis	30.2	CD79A CD4 ALB

Graphical network of the top 20 diseases related to Amebiasis:

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Symptoms & Phenotypes for Amebiasis

MGI Mouse Phenotypes related to Amebiasis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	AIG1 ALB CABP5 CD4 CD79A COL1A2
2	neoplasm	MP:0002006	9.92	ALB CD79A FN1 ICAM1 IL1B IL6
3	liver/biliary system	MP:0005370	9.86	ALB CD79A FN1 IL17A IL6 REG1B
4	immune system	MP:0005387	9.73	ALB CD4 CD79A COL1A2 FN1 ICAM1
5	integument	MP:0010771	9.32	CD4 COL1A2 COL5A2 FN1 ICAM1 IL17A

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Drugs & Therapeutics for Amebiasis

Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

23431961

2

Mebendazole

Approved, Vet_approved

Phase 4

31431-39-7

4030

3

Piperazine

Approved, Vet_approved

Phase 4

110-85-0

4837

4

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

5

Anti-Infective Agents

Phase 4

6

Antimitotic Agents

Phase 4

7

Anthelmintics

Phase 4

8

Antiparasitic Agents

Phase 4

9

Tubulin Modulators

Phase 4

10

Citrate

Phase 4

11

Piperazine citrate

Phase 4

12

DMP 777

Phase 4

157341-41-8

13

Nitazoxanide

Approved, Investigational, Vet_approved

Phase 3

55981-09-4

41684

14

Auranofin

Approved, Investigational

Phase 1

34031-32-8

6918453 16667669 70788951

15

Antirheumatic Agents

Phase 1

16

Formaldehyde

Approved, Vet_approved

50-00-0

712

17

Diethyl ether

Experimental

60-29-7

3283

18

Disinfectants

19

Liver Extracts

20

Cola

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population	Completed	NCT02385058	Phase 4	Mebendazole;Quinfamide;Placebo
2	Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Suspension in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Children	Completed	NCT00366730	Phase 3	Nitazoxanide
3	Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Tablets in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Adults and Adolescents	Completed	NCT00366236	Phase 3	Nitazoxanide
4	An Open Label, Multiple Dose Study to Evaluate the Pharmacokinetics of Auranofin Following Oral Dose Administration for 7 Days to Healthy Subjects	Completed	NCT02089048	Phase 1	Auranofin
5	Field Studies of Human Immunity to Amebiasis in Bangladesh: A Prospective Study of Children Ages 0-17 Years	Completed	NCT02734264
6	AMEPAROMO CAPSULES 250 MG DRUG USE INVESTIGATION	Completed	NCT02680665
7	Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal	Completed	NCT02105714
8	Primary Cecal Pathologies Presenting as Acute Abdomen and Critical Appraisal of Their Current Management Strategies	Completed	NCT03262025
9	Study of Patients With Parasitic Infections of the Gastrointestinal Tract	Terminated	NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Chloroquine

Chloroquine hydrochloride

chloroquine phosphate

Emetine

Emetine Hydrochloride

Iodoquinol

Metronidazole

Metronidazole Hydrochloride

METRONIDAZOLE PWDR

Cochrane evidence based reviews: amebiasis

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Genetic Tests for Amebiasis

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Anatomical Context for Amebiasis

Organs/tissues related to Amebiasis:

MalaCards : Colon, Liver, Brain, Bone Marrow, Small Intestine, T Cells, Lung

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Publications for Amebiasis

Articles related to Amebiasis:

(show top 50) (show all 5868)

#	Title	Authors	PMID	Year
1	Secretory immune response in patients with intestinal amoebiasis. ⁵³ ⁶²	Ortiz-Ortiz L...Rosales-Borjas DM	9797512	1998
2	Some immunological studies on amoebiasis. ⁵³ ⁶²	el-Ganayni GA...el-Naggar HM	8077755	1994
3	Human secretory immunoglobulin A anti-Entamoeba histolytica antibodies inhibit adherence of amebae to MDCK cells. ⁵³ ⁶²	Carrero JC...Ortiz-Ortiz L	8300242	1994
4	Diagnosis of intestinal amebiasis using salivary IgA antibody detection. ⁵³ ⁶²	del Muro R...Ortiz-Ortiz L	2230266	1990
5	[Fecal and serum anti-amebic antibodies in acute intestinal amebiasis]. ⁵³ ⁶²	Ximenez C...Ramiro M	2136492	1990
6	A case of amebic colitis and liver abscesses that occurred after treatment of coronavirus disease 2019 with dexamethasone. ⁶²	Motobayashi K...Tokoro M	36447935	2023
7	Hypothetical proteins play a role in stage conversion, virulence, and the stress response in the Entamoeba species. ⁶²	Walters HA...Temesvari LA	36309065	2022
8	The mitosome of the anaerobic parasitic protist Entamoeba histolytica: A peculiar and minimalist mitochondrion-related organelle. ⁶²	Santos HJ...Nozaki T	35588086	2022
9	Effect of Entamoeba histolytica infection on gut microbial diversity and composition in diarrheal patients from New Delhi. ⁶²	Iyer LR...Bhattacharya A	36399171	2022
10	Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development. ⁶²	Jasni N...Othman N	36363634	2022
11	[Evaluation of the Methods Used for the Detection of Entamoeba histolytica in Stool Samples of Patients with Diarrhea]. ⁶²	Tortop S...Ogunc D	36458714	2022
12	Development of a simple PCR-RFLP technique for detection and differentiation of E. histolytica, E. dispar and E. moshkovskii. ⁶²	Sardar SK...Ganguly S	36308533	2022
13	Exploratory toxicology studies of 2,3-substituted imidazo[1,2-a]pyridines with antiparasitic and anti-inflammatory properties. ⁶²	Serrano-Contreras JI...Campos-Aldrete ME	36337253	2022
14	Cecal ameboma and a liver abscess mimicking metastatic colonic cancer. An autochthonous infectious disease in Spain? ⁶²	Fuentes-Valenzuela E...Garcia-Pajares F	35469408	2022
15	Intranasal delivery of a synthetic Entamoeba histolytica vaccine containing adjuvant (LecA + GLA-3 M-052 liposomes): In vitro characterization. ⁶²	Murphy BM...Martin AR	36058408	2022
16	Amebic Liver Abscess Complicated With a Pleural Effusion: A Case Report. ⁶²	Salazar MS...Surainder A	36381913	2022
17	Entamoeba histolytica HM-1: IMSS gene expression profiling identifies key hub genes, potential biomarkers, and pathways in Amoebiasis infection: a systematic network meta-analysis. ⁶²	Verma RN...Sinha DN	36004808	2022
18	Prevalence of Entamoeba histolytica among schoolchildren in Dilla town, Gedeo zone, Ethiopia. ⁶²	Abate M...Hajare ST	36255042	2022
19	Formulation and in vitro evaluation of polymeric metronidazole nanoparticles. ⁶²	Ovenseri AC...Halilu EM	36451561	2022
20	Colitis caused by Entamoeba histolytica identified by real-time-PCR and fluorescence in situ hybridization from formalin-fixed, paraffin-embedded tissue. ⁶²	Muller A...Hagen RM	36136732	2022
21	Development of a salivary IgA detection method for accurate diagnosis of amebiasis. ⁶²	Adao DEV...Rivera WL	36091277	2022
22	Gene expression of axenically-isolated clinical Entamoeba histolytica strains and its impact on disease severity of amebiasis. ⁶²	Yanagawa Y...Watanabe K	36178974	2022
23	How to get away with murder: The multiple strategies employed by pathogenic protozoa to avoid complement killing. ⁶²	Rios-Barros LV...Castro-Gomes T	35709630	2022
24	Amoebic Hepato-Pericardial Fistula Complicating Amoebic Liver Abscess Treated With Pericardiotomy: A Case Report. ⁶²	Alsheikh H...Nashwan AJ	36158434	2022
25	Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections. ⁶²	Britten NS...Butler JA	35366762	2022
26	Sinonasal Amoebiasis: An Unexpected Cause of Sinonasal Necroinflammatory Disease. ⁶²	McLean AC...Rooper LM	35968953	2022
27	ECM proteins involved in cell migration and vessel formation compromise bovine cloned placentation. ⁶²	Barreto RDSN...Miglino MA	35689945	2022
28	Updates on the worldwide burden of amoebiasis: A case series and literature review. ⁶²	Nasrallah J...Izri A	36155852	2022
29	Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability. ⁶²	Mi-Ichi F...Yoshida H	35943216	2022
30	The fecal microbiota of gravidas with fetal growth restriction newborns characterized by metagenomic sequencing. ⁶²	He X...Chen Y	36434943	2022
31	Insight into the Conformational Transitions of Serine Acetyl Transferase Isoforms in E. histolytica: Implications for Structural and Functional Balance. ⁶²	Idrees D...Gourinath S	35874230	2022
32	Identification of Multiple Domains of Entamoeba histolytica Intermediate Subunit Lectin-1 with Hemolytic and Cytotoxic Activities. ⁶²	Kato K...Tachibana H	35887043	2022
33	Ubiquitin of Entamoeba histolytica induces antibody response in patients with invasive amoebiasis. ⁶²	Flores MS...Galan L	35366008	2022
34	Asymptomatic amebiasis diagnosed 10 years after exposure to the pathogen. ⁶²	Yamada T...Hamada K	35800644	2022
35	Minimally invasive treatment of an amebic empyema secondary to the transdiaphragmatic rupture of a liver abscess: a case report. ⁶²	Abello Vaamonde JA...Lorenzo Silva JM	35892123	2022
36	A Comparative Analysis of Microscopy, Coproantigen Serology, and Nested Multiplex PCR in the Laboratory Diagnosis of Entamoeba histolytica Infection. ⁶²	Das S...Olickal JJ	35982881	2022
37	A case of intestinal amoebiasis mimicking intestinal Behçet's disease. ⁶²	Fukui A...Morinobu A	35388431	2022
38	Burden and pattern of acute diarrhea in Thai children under 5 years of age: a 5-year descriptive analysis based on Thailand National Health Coverage (NHC) data. ⁶²	Charoenwat B...Thepsuthammarat K	35689279	2022
39	Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review. ⁶²	Gupta P...Salam N	35404011	2022
40	The Epidemiology of Entamoeba histolytica Infection and Its Associated Risk Factors among Domestic and Imported Patients in Taiwan during the 2011-2020 Period. ⁶²	Lin FH...Yu CP	35744083	2022
41	Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica. ⁶²	Lee YA...Shin MH	35772733	2022
42	EhRho6-mediated actin degradation in Entamoeba histolytica is associated with compromised pathogenicity. ⁶²	Narooka AR...Datta S	35324049	2022
43	Endemic Thoracic Infections in Sub-Saharan Africa. ⁶²	Rydzak CE...Meirelles GSP	35534131	2022
44	A Case Series of Amoebic Liver Abscess in Patients With COVID-19 Infection. ⁶²	Sahney A...Kumar A	34728984	2022
45	[Parasite screening for immunosuppressed traveler]. ⁶²	Carnino L...Eperon G	35510282	2022
46	Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact. ⁶²	Santos HJ...Nozaki T	35404118	2022
47	Insights into the Mechanisms of Lactobacillus acidophilus Activity against Entamoeba histolytica by Using Thiol Redox Proteomics. ⁶²	Sarid L...Ankri S	35624678	2022
48	Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. ⁶²	Rahadiani N...Krisnuhoni E	35544636	2022
49	A rare case of extraintestinal amebiasis. ⁶²	Fu B...Fu X	35410146	2022
50	Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan. ⁶²	Yanagawa Y...Watanabe K	35468146	2022

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Genes for Amebiasis

Genes related to Amebiasis (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	11.45	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	CPA5	Carboxypeptidase A5	Protein Coding	6.72	DISEASES inferred ¹⁴
3	CFHR2	Complement Factor H Related 2	Protein Coding	6.06	DISEASES inferred ¹⁴ ¹⁴
4	AIG1	Androgen Induced 1	Protein Coding	6.04	DISEASES inferred ¹⁴
5	CD79A	CD79a Molecule	Protein Coding	5.69	Novoseek inferred ⁵³	2230266 8300242 9797512 (more) 8077755 2136492
6	TNF	Tumor Necrosis Factor	Protein Coding	5.65	DISEASES inferred ¹⁴
7	CABP5	Calcium Binding Protein 5	Protein Coding	5.65	DISEASES inferred ¹⁴
8	IL17A	Interleukin 17A	Protein Coding	5.58	DISEASES inferred ¹⁴
9	IL1B	Interleukin 1 Beta	Protein Coding	5.55	DISEASES inferred ¹⁴
10	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	5.54	DISEASES inferred ¹⁴
11	FN1	Fibronectin 1	Protein Coding	5.45	DISEASES inferred ¹⁴
12	REG1B	Regenerating Family Member 1 Beta	Protein Coding	5.39	DISEASES inferred ¹⁴
13	CD4	CD4 Molecule	Protein Coding	5.36	DISEASES inferred ¹⁴
14	IGLL5	Immunoglobulin Lambda Like Polypeptide 5	Protein Coding	5.26	DISEASES inferred ¹⁴
15	ALB	Albumin	Protein Coding	5.26	DISEASES inferred ¹⁴
16	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	5.26	DISEASES inferred ¹⁴
17	TLR2	Toll Like Receptor 2	Protein Coding	5.24	DISEASES inferred ¹⁴
18	MYO1B	Myosin IB	Protein Coding	5.24	DISEASES inferred ¹⁴
19	IL6	Interleukin 6	Protein Coding	5.23	DISEASES inferred ¹⁴
20	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	5.21	DISEASES inferred ¹⁴
21	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	5.19	DISEASES inferred ¹⁴
22	TLR4	Toll Like Receptor 4	Protein Coding	5.13	DISEASES inferred ¹⁴
23	IL10	Interleukin 10	Protein Coding	5.12	DISEASES inferred ¹⁴
24	MYO1C	Myosin IC	Protein Coding	5.12	DISEASES inferred ¹⁴
25	IL4	Interleukin 4	Protein Coding	5.07	DISEASES inferred ¹⁴
26	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	5.07	DISEASES inferred ¹⁴
27	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.07	DISEASES inferred ¹⁴
28	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	5.06	DISEASES inferred ¹⁴
29	IGLL1	Immunoglobulin Lambda Like Polypeptide 1	Protein Coding	5.06	DISEASES inferred ¹⁴
30	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	5.06	DISEASES inferred ¹⁴
31	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	5.05	DISEASES inferred ¹⁴
32	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	5.02	DISEASES inferred ¹⁴
33	CTSL	Cathepsin L	Protein Coding	5.02	DISEASES inferred ¹⁴
34	METAP2	Methionyl Aminopeptidase 2	Protein Coding	4.94	DISEASES inferred ¹⁴
35	LAMA4	Laminin Subunit Alpha 4	Protein Coding	4.93	DISEASES inferred ¹⁴

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Variations for Amebiasis

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Expression for Amebiasis

Search GEO for disease gene expression data for Amebiasis.

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Pathways for Amebiasis

Pathways related to Amebiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.97	CD4 CD79A CFHR2 COL1A2 CXCL8 FN1
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.84	CD4 COL1A2 COL5A2 CXCL8 FN1 IL17A
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.41	TNF TLR2 IL6 IL1B IL17A CXCL8
4	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.31	TNF MYO1B IL6 IL1B IL17A CXCL8
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.3	TNF IL6 IL1B IL17A ICAM1 FN1
6	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.85	TNF TLR2 IL6 IL1B CXCL8
7	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.63	TNF TLR2 IL6 IL1B CXCL8
8	NF-kappaB Signaling ³	12.59	TNF TLR2 IL1B IL17A CD79A
9	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.58	TNF IL6 IL1B IL17A FN1 CD4
10	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.54	TNF TLR2 IL6 IL1B CXCL8
11	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.42	TNF TLR2 IL6 IL1B FN1 CXCL8
12	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.32	TNF IL6 IL1B CXCL8
13	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.29	TNF TLR2 IL6 IL17A CXCL8
14	ECM proteoglycans ⁶⁶ Show member pathways Integrin cell surface interactions ⁶⁶ MED and pseudoachondroplasia genes ⁷⁴	12.22	ICAM1 FN1 COL5A2 COL1A2
15	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.19	CXCL8 IL1B IL6 TNF
16	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.03	TNF IL6 CD79A CD4
17	Spinal cord injury ⁷⁴	12.02	TNF IL6 IL1B ICAM1 CXCL8
18	Senescence and autophagy in cancer ⁷⁴	11.98	IL6 IL1B FN1 CXCL8
19	CCL18 signaling pathway ⁷⁴	11.93	IL6 FN1 CXCL8 COL1A2
20	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.9	IL6 IL17A ICAM1 CXCL8
21	Allograft rejection ⁷⁴	11.9	TNF IL1B IL17A CXCL8
22	Innate Lymphoid Cells Differentiation ⁶⁵	11.83	TNF IL1B IL17A CD4
23	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.83	TLR2 IL6 IL1B IL17A CD4
24	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.79	TNF IL6 IL1B CD4
25	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.78	IL6 CXCL8 CD4
26	Glucocorticoid receptor regulatory network ⁶¹	11.78	IL6 ICAM1 CXCL8
27	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.74	TNF IL6 CD79A
28	Th17 cell differentiation pathway ⁷⁴	11.74	IL6 IL1B IL17A CD4
29	AP-1 transcription factor network ⁶¹	11.73	IL6 CXCL8 COL1A2
30	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.73	TNF TLR2 IL6 IL1B IL17A CD4
31	Lung fibrosis ⁷⁴	11.69	CXCL8 IL1B IL6 TNF
32	IL 10 signaling pathway ⁶⁷	11.68	IL1B IL6 TNF
33	miRNAs involvement in the immune response in sepsis ⁷⁴	11.68	TNF IL6 ICAM1 CXCL8
34	Cell adhesion_ECM remodeling ²²	11.67	FN1 CXCL8 COL1A2
35	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.65	TNF TLR2 IL6
36	Integrins in angiogenesis ⁶¹	11.63	FN1 COL5A2 COL1A2
37	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.58	TNF IL6 CXCL8
38	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.57	CXCL8 ICAM1 IL1B IL6 TNF
39	MSP-RON Signaling ⁶⁴	11.55	TNF TLR2 IL1B
40	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	TNF IL6 IL1B
41	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.5	ICAM1 FN1 CXCL8
42	miRNA targets in ECM and membrane receptors ⁷⁴	11.43	FN1 COL5A2 COL1A2
43	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	11.39	IL6 CXCL8 COL1A2
44	IL-10 Pathway ⁶⁴	11.39	TNF IL6 IL1B
45	Interleukin-10 signaling ⁶⁶	11.39	TNF IL6 IL1B ICAM1 CXCL8
46	Development and heterogeneity of the ILC family ⁷⁴	11.34	IL17A IL1B IL6 TNF
47	Burn wound healing ⁷⁴	11.31	TNF IL6 IL1B ICAM1 CXCL8 COL1A2
48	amb2 Integrin signaling ⁶¹	11.3	TNF IL6 ICAM1
49	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.29	TNF IL6 IL1B CXCL8
50	Cytokines and inflammatory response ⁷⁴	11.26	TNF IL6 IL1B CD4

Sources

GO Terms for Amebiasis

Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	10.1	TNF IL17A IGLL5 ICAM1 CD79A CD4
2	extracellular region	GO:0005576	10.02	ALB CFHR2 COL1A2 COL5A2 CPA5 CXCL8
3	membrane raft	GO:0045121	9.96	TNF TLR2 ICAM1 CD79A CD4
4	endoplasmic reticulum lumen	GO:0005788	9.93	ALB CD4 COL1A2 COL5A2 FN1 IL6
5	extracellular space	GO:0005615	9.74	TNF REG1B IL6 IL1B IL17A ICAM1

Biological processes related to Amebiasis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.3	CXCL8 IL17A IL1B IL6 TLR2 TNF
2	immune response	GO:0006955	10.11	TNF TLR2 IL6 IL1B IL17A CXCL8
3	regulation of insulin secretion	GO:0050796	10.04	TNF IL6 IL1B
4	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.02	TNF TLR2 IL1B
5	defense response to Gram-positive bacterium	GO:0050830	10.02	TNF TLR2 IL6 IL1B IL17A
6	positive regulation of interleukin-8 production	GO:0032757	10.01	IL1B IL6 TLR2 TNF
7	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.95	TNF IL6 IL17A
8	negative regulation of neurogenesis	GO:0050768	9.93	TNF IL6 IL1B
9	positive regulation of glial cell proliferation	GO:0060252	9.91	TNF IL6 IL1B
10	positive regulation of fever generation	GO:0031622	9.86	TNF IL1B
11	sequestering of triglyceride	GO:0030730	9.84	TNF IL1B
12	leukocyte migration	GO:0050900	9.81	TNF IL1B ICAM1
13	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.8	TNF IL1B
14	positive regulation of chemokine production	GO:0032722	9.8	IL1B IL6 TLR2 TNF
15	positive regulation of interleukin-6 production	GO:0032755	9.65	TNF TLR2 IL6 IL1B IL17A
16	positive regulation of neuroinflammatory response	GO:0150078	9.63	TNF IL6 IL1B
17	vascular endothelial growth factor production	GO:0010573	9.1	TNF IL6 IL1B

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	9.56	FN1 COL5A2 COL1A2 CD4
2	cytokine activity	GO:0005125	9.28	TNF IL6 IL1B IL17A CXCL8

Sources

Sources for Amebiasis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: AMB001 MIFTS: 51	Amebiasis Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Amebiasis

Aliases & Classifications for Amebiasis

MalaCards integrated aliases for Amebiasis:

Classifications:

External Ids:

Summaries for Amebiasis

Related Diseases for Amebiasis

Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Amebiasis:

Symptoms & Phenotypes for Amebiasis

MGI Mouse Phenotypes related to Amebiasis:

Drugs & Therapeutics for Amebiasis

Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: amebiasis

Genetic Tests for Amebiasis

Anatomical Context for Amebiasis

Organs/tissues related to Amebiasis:

Publications for Amebiasis

Articles related to Amebiasis:

Genes for Amebiasis

Genes related to Amebiasis (0 elite genes):

Variations for Amebiasis

Expression for Amebiasis

Pathways for Amebiasis

Pathways related to Amebiasis according to GeneCards Suite gene sharing:

GO Terms for Amebiasis

Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

Biological processes related to Amebiasis according to GeneCards Suite gene sharing:

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

Sources for Amebiasis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :