MCID: AMB001
MIFTS: 51

Amebiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases
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Aliases & Classifications for Amebiasis

MalaCards integrated aliases for Amebiasis:

Name: Amebiasis 11 75 43 14 16 71 75 33
Amoebiasis 11 75 31 33
Entamoebiasis 11 71 33
Chronic Intestinal Amebiasis 11 71
Infection Due to Entamoeba Histolytica 33
Disease Due to Endamoebidae 33
Amoebiasis, Unspecified 33
Amoebic Enteritis 71
Amoebic Infection 33
Amebic Colitis 71
Amoebiasis Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:9181
ICD9CM 34 006
MeSH 43 D000562
NCIt 49 C84551
SNOMED-CT 68 387754006
ICD10 31 A06 A06.9
UMLS 71 C0002438 C0002440 C0013370 more

Summaries for Amebiasis

Disease Ontology: 11 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

MalaCards based summary: Amebiasis, also known as amoebiasis, is related to dysentery and giardiasis. An important gene associated with Amebiasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium citrate and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and brain, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia: 75 Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba... more...

Related Diseases for Amebiasis

Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)
# Related Disease Score Top Affiliating Genes
1 dysentery 31.2 TNF IL6 IL1B CXCL8 CD4 ALB
2 giardiasis 31.2 IL17A CD79A CD4 ALB
3 schistosomiasis 30.9 TNF IL17A ALB
4 inflammatory bowel disease 1 30.8 TNF TLR2 IL6 IL1B IL17A
5 appendicitis 30.7 TNF IL6 IL1B IL17A CXCL8 ALB
6 pleural empyema 30.7 IL6 CD79A CD4 ALB
7 diarrhea 30.7 TNF IL6 IL1B CXCL8 ALB
8 bowel dysfunction 30.7 TNF IL6 IL1B ALB
9 ulcerative colitis 30.6 TNF TLR2 IL6 IL1B IL17A CXCL8
10 pericarditis 30.6 TNF IL6 IL1B CXCL8
11 cholera 30.6 TNF IL6 IL1B CXCL8 CD79A
12 toxoplasmosis 30.6 TNF IL6 IL1B IL17A CD79A
13 gastritis 30.5 TNF IL6 IL1B IL17A CXCL8
14 colitis 30.5 TNF TLR2 IL6 IL1B IL17A CXCL8
15 cryptosporidiosis 30.5 TNF CD79A CD4
16 peritonitis 30.5 TNF TLR2 IL6 IL1B IL17A ICAM1
17 pleurisy 30.5 TNF IL1B CXCL8
18 echinococcosis 30.5 TNF TLR2 IL6 IL17A
19 plasmodium falciparum malaria 30.4 TNF IL6 ICAM1
20 trichomoniasis 30.4 TNF IL6 IL1B CXCL8 CD4
21 encephalitis 30.4 TNF TLR2 IL6 IL1B CXCL8
22 lung abscess 30.4 TNF IL6 IL1B CD4 ALB
23 intestinal perforation 30.4 TNF IL6 CD4 ALB
24 neurotic disorder 30.4 TNF IL6 IL1B
25 acute diarrhea 30.4 CXCL8 CD4 ALB
26 filarial elephantiasis 30.4 TNF TLR2 CD4
27 acquired immunodeficiency syndrome 30.3 TNF IL6 IL1B ICAM1 CD79A CD4
28 syphilis 30.3 TNF TLR2 IL17A FN1 CD79A CD4
29 urticaria 30.3 TNF IL6 IL1B IL17A CXCL8 CD4
30 duodenal ulcer 30.3 TNF IL6 IL1B CXCL8
31 pemphigus 30.3 TNF IL6 IL17A CD79A
32 proliferative glomerulonephritis 30.3 CFHR2 CD79A ALB
33 typhoid fever 30.3 TNF IL6 IL1B ALB
34 pericardial effusion 30.2 TNF IL6 CD4 ALB
35 inflammatory bowel disease 30.2 TNF TLR2 IL6 IL1B IL17A ICAM1
36 leishmaniasis 30.2 TNF TLR2 IL6 IL1B IL17A CXCL8
37 intestinal schistosomiasis 30.2 TNF IL17A CD4
38 immune deficiency disease 30.2 TNF TLR2 IL6 IL1B IL17A FN1
39 clonorchiasis 30.2 TNF CXCL8 CD79A
40 pyoderma gangrenosum 30.2 TNF IL1B CXCL8
41 viral hepatitis 30.2 TLR2 IL6 ICAM1 ALB
42 polyarteritis nodosa 30.2 TNF IL6 ICAM1
43 choroiditis 30.2 TNF IL17A CD4
44 granulomatous hepatitis 30.2 TNF CD4 ALB
45 pyoderma 30.2 TNF IL1B IL17A CXCL8
46 pneumocystosis 30.2 TNF IL6 IL17A CD4 ALB
47 miliary tuberculosis 30.2 TNF CD4 ALB
48 aspergillosis 30.2 TNF TLR2 IL6 IL1B CXCL8
49 pulmonary tuberculosis 30.2 TNF TLR2 IL6 IL1B ALB
50 parotitis 30.2 CD79A CD4 ALB

Graphical network of the top 20 diseases related to Amebiasis:



Diseases related to Amebiasis

Symptoms & Phenotypes for Amebiasis

MGI Mouse Phenotypes related to Amebiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 AIG1 ALB CABP5 CD4 CD79A COL1A2
2 neoplasm MP:0002006 9.92 ALB CD79A FN1 ICAM1 IL1B IL6
3 liver/biliary system MP:0005370 9.86 ALB CD79A FN1 IL17A IL6 REG1B
4 immune system MP:0005387 9.73 ALB CD4 CD79A COL1A2 FN1 ICAM1
5 integument MP:0010771 9.32 CD4 COL1A2 COL5A2 FN1 ICAM1 IL17A

Drugs & Therapeutics for Amebiasis

Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2 23431961
2
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
3
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
4
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
5 Anti-Infective Agents Phase 4
6 Antimitotic Agents Phase 4
7 Anthelmintics Phase 4
8 Antiparasitic Agents Phase 4
9 Tubulin Modulators Phase 4
10 Citrate Phase 4
11 Piperazine citrate Phase 4
12 DMP 777 Phase 4 157341-41-8
13
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
14
Auranofin Approved, Investigational Phase 1 34031-32-8 6918453 16667669 70788951
15 Antirheumatic Agents Phase 1
16
Formaldehyde Approved, Vet_approved 50-00-0 712
17
Diethyl ether Experimental 60-29-7 3283
18 Disinfectants
19 Liver Extracts
20 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4 Mebendazole;Quinfamide;Placebo
2 Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Suspension in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Children Completed NCT00366730 Phase 3 Nitazoxanide
3 Multi-Center, Double-Blind, Placebo-Controlled Study of Nitazoxanide Tablets in the Treatment of Diarrhea Caused by Entamoeba Histolytica in Adults and Adolescents Completed NCT00366236 Phase 3 Nitazoxanide
4 An Open Label, Multiple Dose Study to Evaluate the Pharmacokinetics of Auranofin Following Oral Dose Administration for 7 Days to Healthy Subjects Completed NCT02089048 Phase 1 Auranofin
5 Field Studies of Human Immunity to Amebiasis in Bangladesh: A Prospective Study of Children Ages 0-17 Years Completed NCT02734264
6 AMEPAROMO CAPSULES 250 MG DRUG USE INVESTIGATION Completed NCT02680665
7 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
8 Primary Cecal Pathologies Presenting as Acute Abdomen and Critical Appraisal of Their Current Management Strategies Completed NCT03262025
9 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Chloroquine
Chloroquine hydrochloride
chloroquine phosphate
Emetine
Emetine Hydrochloride
Iodoquinol
Metronidazole
Metronidazole Hydrochloride
METRONIDAZOLE PWDR

Cochrane evidence based reviews: amebiasis

Genetic Tests for Amebiasis

Anatomical Context for Amebiasis

Organs/tissues related to Amebiasis:

MalaCards : Colon, Liver, Brain, Bone Marrow, Small Intestine, T Cells, Lung

Publications for Amebiasis

Articles related to Amebiasis:

(show top 50) (show all 5868)
# Title Authors PMID Year
1
Secretory immune response in patients with intestinal amoebiasis. 53 62
9797512 1998
2
Some immunological studies on amoebiasis. 53 62
8077755 1994
3
Human secretory immunoglobulin A anti-Entamoeba histolytica antibodies inhibit adherence of amebae to MDCK cells. 53 62
8300242 1994
4
Diagnosis of intestinal amebiasis using salivary IgA antibody detection. 53 62
2230266 1990
5
[Fecal and serum anti-amebic antibodies in acute intestinal amebiasis]. 53 62
2136492 1990
6
A case of amebic colitis and liver abscesses that occurred after treatment of coronavirus disease 2019 with dexamethasone. 62
36447935 2023
7
Hypothetical proteins play a role in stage conversion, virulence, and the stress response in the Entamoeba species. 62
36309065 2022
8
The mitosome of the anaerobic parasitic protist Entamoeba histolytica: A peculiar and minimalist mitochondrion-related organelle. 62
35588086 2022
9
Effect of Entamoeba histolytica infection on gut microbial diversity and composition in diarrheal patients from New Delhi. 62
36399171 2022
10
Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development. 62
36363634 2022
11
[Evaluation of the Methods Used for the Detection of Entamoeba histolytica in Stool Samples of Patients with Diarrhea]. 62
36458714 2022
12
Development of a simple PCR-RFLP technique for detection and differentiation of E. histolytica, E. dispar and E. moshkovskii. 62
36308533 2022
13
Exploratory toxicology studies of 2,3-substituted imidazo[1,2-a]pyridines with antiparasitic and anti-inflammatory properties. 62
36337253 2022
14
Cecal ameboma and a liver abscess mimicking metastatic colonic cancer. An autochthonous infectious disease in Spain? 62
35469408 2022
15
Intranasal delivery of a synthetic Entamoeba histolytica vaccine containing adjuvant (LecA + GLA-3 M-052 liposomes): In vitro characterization. 62
36058408 2022
16
Amebic Liver Abscess Complicated With a Pleural Effusion: A Case Report. 62
36381913 2022
17
Entamoeba histolytica HM-1: IMSS gene expression profiling identifies key hub genes, potential biomarkers, and pathways in Amoebiasis infection: a systematic network meta-analysis. 62
36004808 2022
18
Prevalence of Entamoeba histolytica among schoolchildren in Dilla town, Gedeo zone, Ethiopia. 62
36255042 2022
19
Formulation and in vitro evaluation of polymeric metronidazole nanoparticles. 62
36451561 2022
20
Colitis caused by Entamoeba histolytica identified by real-time-PCR and fluorescence in situ hybridization from formalin-fixed, paraffin-embedded tissue. 62
36136732 2022
21
Development of a salivary IgA detection method for accurate diagnosis of amebiasis. 62
36091277 2022
22
Gene expression of axenically-isolated clinical Entamoeba histolytica strains and its impact on disease severity of amebiasis. 62
36178974 2022
23
How to get away with murder: The multiple strategies employed by pathogenic protozoa to avoid complement killing. 62
35709630 2022
24
Amoebic Hepato-Pericardial Fistula Complicating Amoebic Liver Abscess Treated With Pericardiotomy: A Case Report. 62
36158434 2022
25
Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections. 62
35366762 2022
26
Sinonasal Amoebiasis: An Unexpected Cause of Sinonasal Necroinflammatory Disease. 62
35968953 2022
27
ECM proteins involved in cell migration and vessel formation compromise bovine cloned placentation. 62
35689945 2022
28
Updates on the worldwide burden of amoebiasis: A case series and literature review. 62
36155852 2022
29
Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability. 62
35943216 2022
30
The fecal microbiota of gravidas with fetal growth restriction newborns characterized by metagenomic sequencing. 62
36434943 2022
31
Insight into the Conformational Transitions of Serine Acetyl Transferase Isoforms in E. histolytica: Implications for Structural and Functional Balance. 62
35874230 2022
32
Identification of Multiple Domains of Entamoeba histolytica Intermediate Subunit Lectin-1 with Hemolytic and Cytotoxic Activities. 62
35887043 2022
33
Ubiquitin of Entamoeba histolytica induces antibody response in patients with invasive amoebiasis. 62
35366008 2022
34
Asymptomatic amebiasis diagnosed 10 years after exposure to the pathogen. 62
35800644 2022
35
Minimally invasive treatment of an amebic empyema secondary to the transdiaphragmatic rupture of a liver abscess: a case report. 62
35892123 2022
36
A Comparative Analysis of Microscopy, Coproantigen Serology, and Nested Multiplex PCR in the Laboratory Diagnosis of Entamoeba histolytica Infection. 62
35982881 2022
37
A case of intestinal amoebiasis mimicking intestinal Behçet's disease. 62
35388431 2022
38
Burden and pattern of acute diarrhea in Thai children under 5 years of age: a 5-year descriptive analysis based on Thailand National Health Coverage (NHC) data. 62
35689279 2022
39
Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review. 62
35404011 2022
40
The Epidemiology of Entamoeba histolytica Infection and Its Associated Risk Factors among Domestic and Imported Patients in Taiwan during the 2011-2020 Period. 62
35744083 2022
41
Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica. 62
35772733 2022
42
EhRho6-mediated actin degradation in Entamoeba histolytica is associated with compromised pathogenicity. 62
35324049 2022
43
Endemic Thoracic Infections in Sub-Saharan Africa. 62
35534131 2022
44
A Case Series of Amoebic Liver Abscess in Patients With COVID-19 Infection. 62
34728984 2022
45
[Parasite screening for immunosuppressed traveler]. 62
35510282 2022
46
Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact. 62
35404118 2022
47
Insights into the Mechanisms of Lactobacillus acidophilus Activity against Entamoeba histolytica by Using Thiol Redox Proteomics. 62
35624678 2022
48
Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. 62
35544636 2022
49
A rare case of extraintestinal amebiasis. 62
35410146 2022
50
Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan. 62
35468146 2022

Variations for Amebiasis

Expression for Amebiasis

Search GEO for disease gene expression data for Amebiasis.

Pathways for Amebiasis

Pathways related to Amebiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD4 CD79A CFHR2 COL1A2 CXCL8 FN1
2
Show member pathways
13.84 CD4 COL1A2 COL5A2 CXCL8 FN1 IL17A
3
Show member pathways
13.41 TNF TLR2 IL6 IL1B IL17A CXCL8
4
Show member pathways
13.31 TNF MYO1B IL6 IL1B IL17A CXCL8
5
Show member pathways
13.3 TNF IL6 IL1B IL17A ICAM1 FN1
6
Show member pathways
12.85 TNF TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.63 TNF TLR2 IL6 IL1B CXCL8
8 12.59 TNF TLR2 IL1B IL17A CD79A
9
Show member pathways
12.58 TNF IL6 IL1B IL17A FN1 CD4
10
Show member pathways
12.54 TNF TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.42 TNF TLR2 IL6 IL1B FN1 CXCL8
12
Show member pathways
12.32 TNF IL6 IL1B CXCL8
13
Show member pathways
12.29 TNF TLR2 IL6 IL17A CXCL8
14
Show member pathways
12.22 ICAM1 FN1 COL5A2 COL1A2
15 12.19 CXCL8 IL1B IL6 TNF
16 12.03 TNF IL6 CD79A CD4
17 12.02 TNF IL6 IL1B ICAM1 CXCL8
18 11.98 IL6 IL1B FN1 CXCL8
19 11.93 IL6 FN1 CXCL8 COL1A2
20
Show member pathways
11.9 IL6 IL17A ICAM1 CXCL8
21 11.9 TNF IL1B IL17A CXCL8
22 11.83 TNF IL1B IL17A CD4
23
Show member pathways
11.83 TLR2 IL6 IL1B IL17A CD4
24 11.79 TNF IL6 IL1B CD4
25
Show member pathways
11.78 IL6 CXCL8 CD4
26 11.78 IL6 ICAM1 CXCL8
27 11.74 TNF IL6 CD79A
28 11.74 IL6 IL1B IL17A CD4
29 11.73 IL6 CXCL8 COL1A2
30
Show member pathways
11.73 TNF TLR2 IL6 IL1B IL17A CD4
31 11.69 CXCL8 IL1B IL6 TNF
32 11.68 IL1B IL6 TNF
33 11.68 TNF IL6 ICAM1 CXCL8
34 11.67 FN1 CXCL8 COL1A2
35
Show member pathways
11.65 TNF TLR2 IL6
36 11.63 FN1 COL5A2 COL1A2
37 11.58 TNF IL6 CXCL8
38
Show member pathways
11.57 CXCL8 ICAM1 IL1B IL6 TNF
39 11.55 TNF TLR2 IL1B
40 11.52 TNF IL6 IL1B
41 11.5 ICAM1 FN1 CXCL8
42 11.43 FN1 COL5A2 COL1A2
43 11.39 IL6 CXCL8 COL1A2
44 11.39 TNF IL6 IL1B
45 11.39 TNF IL6 IL1B ICAM1 CXCL8
46 11.34 IL17A IL1B IL6 TNF
47 11.31 TNF IL6 IL1B ICAM1 CXCL8 COL1A2
48 11.3 TNF IL6 ICAM1
49 11.29 TNF IL6 IL1B CXCL8
50 11.26 TNF IL6 IL1B CD4

GO Terms for Amebiasis

Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 10.1 TNF IL17A IGLL5 ICAM1 CD79A CD4
2 extracellular region GO:0005576 10.02 ALB CFHR2 COL1A2 COL5A2 CPA5 CXCL8
3 membrane raft GO:0045121 9.96 TNF TLR2 ICAM1 CD79A CD4
4 endoplasmic reticulum lumen GO:0005788 9.93 ALB CD4 COL1A2 COL5A2 FN1 IL6
5 extracellular space GO:0005615 9.74 TNF REG1B IL6 IL1B IL17A ICAM1

Biological processes related to Amebiasis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.3 CXCL8 IL17A IL1B IL6 TLR2 TNF
2 immune response GO:0006955 10.11 TNF TLR2 IL6 IL1B IL17A CXCL8
3 regulation of insulin secretion GO:0050796 10.04 TNF IL6 IL1B
4 lipopolysaccharide-mediated signaling pathway GO:0031663 10.02 TNF TLR2 IL1B
5 defense response to Gram-positive bacterium GO:0050830 10.02 TNF TLR2 IL6 IL1B IL17A
6 positive regulation of interleukin-8 production GO:0032757 10.01 IL1B IL6 TLR2 TNF
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.95 TNF IL6 IL17A
8 negative regulation of neurogenesis GO:0050768 9.93 TNF IL6 IL1B
9 positive regulation of glial cell proliferation GO:0060252 9.91 TNF IL6 IL1B
10 positive regulation of fever generation GO:0031622 9.86 TNF IL1B
11 sequestering of triglyceride GO:0030730 9.84 TNF IL1B
12 leukocyte migration GO:0050900 9.81 TNF IL1B ICAM1
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.8 TNF IL1B
14 positive regulation of chemokine production GO:0032722 9.8 IL1B IL6 TLR2 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.65 TNF TLR2 IL6 IL1B IL17A
16 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6 IL1B
17 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.56 FN1 COL5A2 COL1A2 CD4
2 cytokine activity GO:0005125 9.28 TNF IL6 IL1B IL17A CXCL8

Sources for Amebiasis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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