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MCID: AMB001
MIFTS: 47

Amebiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Amebiasis

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MalaCards integrated aliases for Amebiasis:

Name: Amebiasis 12 76 53 44 15 73
Amoebiasis Due to Entamoeba Histolytica 53 59
Chronic Intestinal Amebiasis 12 73
Entamoebiasis 12 73
Amoebic Dysentery Due to Entamoeba Histolytica 53
Intestinal Amebiasis 53
Amoebic Enteritis 73
Amebic Dysentery 53
Amebic Colitis 73
Amoebiasis 12

Characteristics:

Orphanet epidemiological data:

59
amoebiasis due to entamoeba histolytica
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9181
ICD10 33 A06 A06.9
ICD9CM 35 006 006.9
MeSH 44 D000562
NCIt 50 C84551
Orphanet 59 ORPHA67
MESH via Orphanet 45 C531613
UMLS via Orphanet 74 C2930799
Sources

Summaries for Amebiasis

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CDC : 3 Amebiasis is a disease caused by the parasite Entamoeba histolytica. It can affect anyone, although it is more common in people who live in tropical areas with poor sanitary conditions. Diagnosis can be difficult because other parasites can look very similar to E. histolytica when seen under a microscope. Infected people do not always become sick. If your doctor determines that you are infected and need treatment, medication is available.

MalaCards based summary : Amebiasis, also known as amoebiasis due to entamoeba histolytica, is related to leukocyte adhesion deficiency, type i and amoebiasis due to free-living amoebae. An important gene associated with Amebiasis is IL17A (Interleukin 17A), and among its related pathways/superpathways are Visual Cycle in Retinal Rods and Primary immunodeficiency. The drugs Mebendazole and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

Wikipedia : 76 Amoebiasis, also known amoebic dysentery, is an infection caused by any of the amobae of the Entamoeba... more...

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Related Diseases for Amebiasis

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Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 leukocyte adhesion deficiency, type i 30.0 ICAM1 IL17A
2 amoebiasis due to free-living amoebae 12.3
3 colitis 10.3
4 hepatitis 10.2
5 autoimmune enteropathy 10.2 ICAM1 IL17A
6 giardiasis 10.2
7 ocular toxoplasmosis 10.2 CD79A IL17A
8 dysentery 10.2
9 hypersensitivity reaction type iii disease 10.2 CD79A ICAM1
10 congenital hypogammaglobulinemia 10.1 CD79A IGLL1
11 agammaglobulinemia, non-bruton type 10.1 CD79A IGLL1
12 henoch-schoenlein purpura 10.1 CD79A ICAM1
13 extrinsic cardiomyopathy 10.1 ICAM1 IL17A
14 shigellosis 10.1
15 appendicitis 10.1
16 trichuriasis 10.1
17 epidemic typhus 10.1
18 dermatitis 10.1
19 exfoliative dermatitis 10.1
20 autoimmune uveitis 10.1 ICAM1 IL17A
21 ulcerative colitis 10.1
22 acquired immunodeficiency syndrome 10.1
23 viral infectious disease 10.1
24 pleurisy 10.0
25 intestinal disease 10.0
26 skin disease 10.0 CD79A ICAM1 IL17A KRT9
27 malaria 10.0
28 arthritis 10.0
29 inflammatory bowel disease 10.0
30 trypanosomiasis 10.0
31 diarrhea 10.0
32 membranoproliferative glomerulonephritis 10.0 CD79A ICAM1
33 rheumatoid arthritis 9.9
34 neutropenia 9.9
35 squamous cell carcinoma 9.9
36 trichomoniasis 9.9
37 adenocarcinoma 9.9
38 purpura 9.9
39 syphilis 9.9
40 toxoplasmosis 9.9
41 pelvic organ prolapse 9.9
42 suppressor of tumorigenicity 3 9.9
43 premature ovarian failure 7 9.9
44 tungiasis 9.9
45 intestinal schistosomiasis 9.9
46 cysticercosis 9.9
47 adrenal cortical hypofunction 9.9
48 acute cystitis 9.9
49 intestinal perforation 9.9
50 vaginitis 9.9

Graphical network of the top 20 diseases related to Amebiasis:



Diseases related to Amebiasis
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Symptoms & Phenotypes for Amebiasis

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Drugs & Therapeutics for Amebiasis

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Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
2
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
4 Anthelmintics Phase 4
5 Citrate Phase 4
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antiparasitic Agents Phase 4,Phase 3
8 Antimitotic Agents Phase 4
9 Piperazine citrate Phase 4
10
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
11
Polihexanide Approved, Investigational Phase 3,Phase 1 28757-47-3
12
Propamidine Experimental, Investigational Phase 3 104-32-5
13 Biguanides Phase 3,Phase 1
14 Ophthalmic Solutions Phase 3,Phase 1
15 Hypoglycemic Agents Phase 3,Phase 1
16 Pharmaceutical Solutions Phase 3,Phase 1
17 Disinfectants Phase 3,Phase 2,Phase 1
18 Antiprotozoal Agents Phase 3
19 Anti-Infective Agents, Local Phase 3,Phase 2
20 Dibrompropamidine Phase 3
21
Auranofin Approved, Investigational Phase 2,Phase 1 34031-32-8 6333901 6918453
22
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
23
Povidone-iodine Approved Phase 2 25655-41-8
24
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
25
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
26
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
27
Povidone Approved Phase 2 9003-39-8
28
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
29
Iodine Approved, Investigational Phase 2 7553-56-2 807
30
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
31 Antirheumatic Agents Phase 2,Phase 1
32 Methylprednisolone acetate Phase 2
33 Chlorhexidine gluconate Phase 2
34 Autonomic Agents Phase 2
35 Neuroprotective Agents Phase 2
36 Prednisolone acetate Phase 2
37 Hormones Phase 2
38 Hormone Antagonists Phase 2
39 Micronutrients Phase 2
40 cadexomer iodine Phase 2
41 Gastrointestinal Agents Phase 2
42 Dermatologic Agents Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
44 Antiemetics Phase 2
45 Plasma Substitutes Phase 2
46 Anti-Inflammatory Agents Phase 2
47 Lubricant Eye Drops Phase 2
48 Antineoplastic Agents, Hormonal Phase 2
49 Trace Elements Phase 2
50 glucocorticoids Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4 Mebendazole;Quinfamide;Placebo
2 Study of Nitazoxanide in the Treatment of Amebiasis in Children Completed NCT00366730 Phase 3 Nitazoxanide
3 Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents Completed NCT00366236 Phase 3 Nitazoxanide
4 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
5 Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
7 Auranofin PK Following Oral Dose Administration Completed NCT02089048 Phase 1 Auranofin
8 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
9 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
10 Field Studies of Amebiasis in Bangladesh Completed NCT02734264
11 Anaemetro I.V. Infusion 500mg Drug Use Investigation Completed NCT03491228
12 Prognosis of Failure Treatment of Amebic Liver Abscess Completed NCT00641992
13 Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
14 Primary Cecal Pathologies Presenting as Acute Abdomen Completed NCT03262025
15 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
16 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
17 Ameparomo Capsules 250 mg Drug Use Investigation Active, not recruiting NCT02680665
18 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable
19 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: amebiasis

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Genetic Tests for Amebiasis

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Anatomical Context for Amebiasis

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MalaCards organs/tissues related to Amebiasis:

41
Colon, Liver, Testes, Lung, Brain, Skin, Bone Marrow
Sources

Publications for Amebiasis

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Articles related to Amebiasis:

(show top 50) (show all 1001)
# Title Authors Year
1
Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis. ( 29739480 )
2018
2
Serodiagnosis of Extraintestinal Amebiasis: Retrospective Evaluation of the Diagnostic Performance of the BordierAr ELISA Kit. ( 29529853 )
2018
3
Chronic urticaria revealing amebiasis. ( 29908957 )
2018
4
A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis. ( 30046644 )
2018
5
The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man. ( 30049805 )
2018
6
Closing The Brief Case: A Rare Case of Invasive Amebiasis Requiring Emergency Subtotal Colectomy in an HIV-Positive Man. ( 30049806 )
2018
7
Learning from the research on amebiasis and gut microbiome: Is stimulation by gut flora essential for effective neutrophil mediated protection from external pathogens? ( 30252579 )
2018
8
Colonic perforation due to amebiasis, a rare and lethal complication. ( 30443315 )
2018
9
Case Report: Endemic Amebiasis in Australia: Implications for Residents, Travelers, and Clinicians. ( 28719303 )
2017
10
A case of amebiasis with negative serologic markers that caused intra-abdominal abscess. ( 28527648 )
2017
11
IL-17A contributes to reducing IFN-I^/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis. ( 28927906 )
2017
12
First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections. ( 28243230 )
2017
13
Gene migration for re-emerging amebiasis in Iran's northwest-Iraq borders: a microevolutionary scale for reflecting epidemiological drift of Entamoeba histolytica metapopulations. ( 27761718 )
2017
14
Penile amebiasis mimicking penile squamous cell carcinoma. ( 28083900 )
2017
15
Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica. ( 27242782 )
2016
16
Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution. ( 27795472 )
2016
17
Modulation of innate immune response by the vagus nerve in experimental hepatic amebiasis in rats. ( 27466057 )
2016
18
Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy. ( 27688666 )
2016
19
Prevalence of Entamoeba spp. in Stool Samples of Patients with Amebiasis Suspect by Native-Lugol and ELISA. ( 27594283 )
2016
20
Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis. ( 27764256 )
2016
21
Vaginal Amebiasis Mimicking Cervical Cancer. ( 27746453 )
2016
22
A Strong Correlation between the Annual Incidence of Amebiasis and Homosexual Human Immunodeficiency Virus Type Infection in Men. ( 26743150 )
2016
23
Entamoeba histolytica: Overexpression of the gal/galnac lectin, ehcp2 and ehcp5 genes in an in vivo model of amebiasis. ( 27616150 )
2016
24
Epidemiology of Domestically Acquired Amebiasis in Japan, 2000-2013. ( 26976888 )
2016
25
Primary Pulmonary Amebiasis Complicated with Multicystic Empyema. ( 27478673 )
2016
26
Neurologic amebiasis caused by Balamuthia mandrillaris in an Indian flying fox (Pteropus giganteus). ( 26762405 )
2016
27
Prevalence of amebiasis in inflammatory bowel disease in University Clinical Hospital Mostar. ( 27652159 )
2016
28
Amebic lung abscess with coexisting lung adenocarcinoma: a unusual case of amebiasis. ( 25550881 )
2014
29
Tropical dermatology: cutaneous larva migrans, gnathostomiasis, cutaneous amebiasis and trombiculiasis. ( 25577853 )
2014
30
Noninvasive intestinal amebiasis: Entamoeba histolytica colonization without invasion. ( 25101557 )
2014
31
Diffuse Hepatic Amebiasis Detected by FDG PET/CT. ( 25275416 )
2014
32
Subjective adverse reactions to metronidazole in patients with amebiasis. ( 24929036 )
2014
33
Laboratory diagnosis of amebiasis in a sample of students from southeastern Brazil and a comparison of microscopy with enzyme-linked immunosorbent assay for screening of infections with Entamoeba sp. ( 24603737 )
2014
34
Asymptomatic intestinal amebiasis in Japanese HIV-1-infected individuals. ( 25048374 )
2014
35
Amebiasis presenting as acute appendicitis: Report of a case and review of Japanese literature. ( 25460473 )
2014
36
Tissue destruction in amebiasis: chew on it. ( 25105188 )
2014
37
Colonoscopic diagnosis of amebiasis: a case series and systematic review. ( 25346004 )
2014
38
Host immune response to intestinal amebiasis. ( 23990778 )
2013
39
Intestinal amebiasis: a concerning cause of acute gastroenteritis among hospitalized lebanese children. ( 24404551 )
2013
40
Case report: Cutaneous amebiasis: the importance of molecular diagnosis of an emerging parasitic disease. ( 23208883 )
2013
41
Intestinal amebiasis in a group of patients with ulcerative colitis: influence on clinical course of the disease. ( 23678829 )
2013
42
An integrated microfluidic device for rapid serodiagnosis of amebiasis. ( 24403984 )
2013
43
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. ( 23775017 )
2013
44
Efficacy and safety of paromomycin for treating amebiasis in Japan. ( 23850836 )
2013
45
Unde venis? Amebiasis presenting as appendicitis. ( 24902389 )
2013
46
Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study. ( 23243179 )
2013
47
Cutaneous amebiasis: 50 years of experience. ( 23409482 )
2012
48
Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis. ( 22318340 )
2012
49
Amebiasis deaths in the United States. ( 22556095 )
2012
50
Clinical case of cerebral amebiasis caused by E. histolytica. ( 21870245 )
2012
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Variations for Amebiasis

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Expression for Amebiasis

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Search GEO for disease gene expression data for Amebiasis.
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Pathways for Amebiasis

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Pathways related to Amebiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Visual Cycle in Retinal Rods 64
10.77 CABP1 CABP2 CABP5
2
Primary immunodeficiency 37
10.72 CD79A IGLL1
3
Development_Thrombopoetin signaling via JAK-STAT pathway 22
10.49 CABP1 CABP2 CABP5
Sources

GO Terms for Amebiasis

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Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 CD79A ICAM1 MYO1C
2 external side of plasma membrane GO:0009897 8.92 CD79A ICAM1 IGLL1 IL17A

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfilament motor activity GO:0000146 8.96 MYO1B MYO1C
2 actin-dependent ATPase activity GO:0030898 8.62 MYO1B MYO1C
Sources

Sources for Amebiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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