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MCID: AMB001
MIFTS: 45

Amebiasis

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Amebiasis

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MalaCards integrated aliases for Amebiasis:

Name: Amebiasis 12 76 53 44 15 73
Amoebiasis Due to Entamoeba Histolytica 53 59
Chronic Intestinal Amebiasis 12 73
Entamoebiasis 12 73
Amoebic Dysentery Due to Entamoeba Histolytica 53
Intestinal Amebiasis 53
Amoebic Enteritis 73
Amebic Dysentery 53
Amebic Colitis 73
Amoebiasis 12

Characteristics:

Orphanet epidemiological data:

59
amoebiasis due to entamoeba histolytica
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9181
ICD10 33 A06 A06.9
ICD9CM 35 006 006.9
MeSH 44 D000562
NCIt 50 C84551
Orphanet 59 ORPHA67
MESH via Orphanet 45 C531613
UMLS via Orphanet 74 C2930799
Sources

Summaries for Amebiasis

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CDC : 3 Amebiasis is a disease caused by the parasite Entamoeba histolytica. It can affect anyone, although it is more common in people who live in tropical areas with poor sanitary conditions. Diagnosis can be difficult because other parasites can look very similar to E. histolytica when seen under a microscope. Infected people do not always become sick. If your doctor determines that you are infected and need treatment, medication is available.

MalaCards based summary : Amebiasis, also known as amoebiasis due to entamoeba histolytica, is related to echinococcosis and amoebiasis due to free-living amoebae. An important gene associated with Amebiasis is IL17A (Interleukin 17A), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Piperazine and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

Wikipedia : 76 Amoebiasis, also known amoebic dysentery, is an infection caused by any of the amoebae of the Entamoeba... more...

Sources

Related Diseases for Amebiasis

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Diseases related to Amebiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 29.9 CD79A IL17A
2 amoebiasis due to free-living amoebae 12.1
3 autoimmune enteropathy 10.7 ICAM1 IL17A
4 heterophyiasis 10.7 CD79A ICAM1
5 ocular toxoplasmosis 10.7 CD79A IL17A
6 asymptomatic neurosyphilis 10.7 CD79A IL17A
7 hymenolepiasis 10.7 CD79A ICAM1
8 rapidly progressive glomerulonephritis 10.6 CD79A ICAM1
9 acute proliferative glomerulonephritis 10.6 CD79A ICAM1
10 hypersensitivity reaction type iii disease 10.6 CD79A ICAM1
11 henoch-schoenlein purpura 10.6 CD79A ICAM1
12 pollen allergy 10.6 CD79A ICAM1
13 erythema multiforme 10.6 CD79A ICAM1
14 diversion colitis 10.6 ICAM1 MUC2
15 lichen disease 10.5 CD79A ICAM1
16 paranasal sinus disease 10.5 CD79A IL17A
17 ventilation pneumonitis 10.5 CD79A IGLL1
18 bird fancier's lung 10.5 CD79A IGLL1
19 agammaglobulinemia, non-bruton type 10.5 CD79A IGLL1
20 respiratory system disease 10.5 CD79A ICAM1 IL17A
21 opportunistic mycosis 10.5 CD79A IL17A
22 congenital hypogammaglobulinemia 10.4 CD79A IGLL1
23 hepatitis 10.4
24 small intestine cancer 10.3 CD79A MUC2
25 nose disease 10.2 CD79A ICAM1
26 skin disease 10.1 CD79A ICAM1 IL17A KRT9
27 b cell deficiency 10.1 CD79A IGLL1
28 colitis 10.1
29 giardiasis 10.1
30 cerebritis 10.1
31 membranoproliferative glomerulonephritis 9.9 CD79A ICAM1
32 appendicitis 9.9
33 inflammatory bowel disease 9.9
34 mucositis 9.9
35 trypanosomiasis 9.9
36 diarrhea 9.9
37 acquired immunodeficiency syndrome 9.9
38 dysentery 9.8
39 squamous cell carcinoma 9.8
40 trichomoniasis 9.8
41 adenocarcinoma 9.8
42 purpura 9.8
43 syphilis 9.8
44 cervical cancer 9.6
45 legionnaire disease 9.6
46 human immunodeficiency virus type 1 9.6
47 lung cancer susceptibility 3 9.6
48 graft-versus-host disease 9.6
49 ulcerative colitis 9.6
50 lymphoma 9.6

Graphical network of the top 20 diseases related to Amebiasis:



Diseases related to Amebiasis
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Symptoms & Phenotypes for Amebiasis

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Drugs & Therapeutics for Amebiasis

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Drugs for Amebiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
2
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
4 Anthelmintics Phase 4
5 Piperazine citrate Phase 4
6 Anti-Infective Agents Phase 4,Phase 3,Phase 1
7 Antiparasitic Agents Phase 4,Phase 3
8 Antimitotic Agents Phase 4
9 Citrate Nutraceutical Phase 4
10
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
11 Propamidine Experimental, Investigational Phase 3 104-32-5
12 Tetrahydrozoline Phase 3,Phase 1
13 Ophthalmic Solutions Phase 3,Phase 1
14 Disinfectants Phase 3,Phase 1
15 Hypoglycemic Agents Phase 3,Phase 1
16 Pharmaceutical Solutions Phase 3,Phase 1
17 Polyhexamethylene biguanide Phase 3,Phase 1
18 Dibrompropamidine Phase 3
19 Anti-Infective Agents, Local Phase 3
20 Antiprotozoal Agents Phase 3
21
Auranofin Approved, Investigational Phase 2,Phase 1 34031-32-8 6333901 6918453
22 Antirheumatic Agents Phase 2,Phase 1
23
Ephedrine Approved Phase 1 299-42-3 9294
24
Pseudoephedrine Approved Phase 1 90-82-4 7028
25 Respiratory System Agents Phase 1
26 Nasal Decongestants Phase 1
27 Vasoconstrictor Agents Phase 1
28 Peripheral Nervous System Agents Phase 1
29 Autonomic Agents Phase 1
30
Formaldehyde Approved, Vet_approved 50-00-0 712
31
Paromomycin Approved, Investigational 1263-89-4, 7542-37-2 165580
32 Ether
33 Antibodies Not Applicable
34 Immunoglobulins Not Applicable
35 Liver Extracts
36 Cola Nutraceutical

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population Completed NCT02385058 Phase 4 Mebendazole;Quinfamide;Placebo
2 Study of Nitazoxanide in the Treatment of Amebiasis in Children Completed NCT00366730 Phase 3 Nitazoxanide
3 Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents Completed NCT00366236 Phase 3 Nitazoxanide
4 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
5 Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
7 Auranofin PK Following Oral Dose Administration Completed NCT02089048 Phase 1 Auranofin
8 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
9 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
10 Field Studies of Amebiasis in Bangladesh Completed NCT02734264
11 Prognosis of Failure Treatment of Amebic Liver Abscess Completed NCT00641992
12 Anaemetro I.V. Infusion 500mg Drug Use Investigation Completed NCT03491228
13 Intestinal Protozoal Infections and Sexual Transmitted Diseases Among Targeted Cohorts Completed NCT00630162
14 Primary Cecal Pathologies Presenting as Acute Abdomen Completed NCT03262025
15 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
16 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
17 Ameparomo Capsules 250 mg Drug Use Investigation Active, not recruiting NCT02680665
18 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable
19 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Amebiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: amebiasis

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Genetic Tests for Amebiasis

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Anatomical Context for Amebiasis

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MalaCards organs/tissues related to Amebiasis:

41
Liver, Colon, Lung, Brain, Testes, Eye, Skin
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Publications for Amebiasis

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Articles related to Amebiasis:

(show top 50) (show all 526)
# Title Authors Year
1
Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis. ( 29739480 )
2018
2
Serodiagnosis of Extraintestinal Amebiasis: Retrospective Evaluation of the Diagnostic Performance of the BordierAr ELISA Kit. ( 29529853 )
2018
3
Chronic urticaria revealing amebiasis. ( 29908957 )
2018
4
Case Report: Endemic Amebiasis in Australia: Implications for Residents, Travelers, and Clinicians. ( 28719303 )
2017
5
A case of amebiasis with negative serologic markers that caused intra-abdominal abscess. ( 28527648 )
2017
6
IL-17A contributes to reducing IFN-I^/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis. ( 28927906 )
2017
7
First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections. ( 28243230 )
2017
8
Gene migration for re-emerging amebiasis in Iran's northwest-Iraq borders: a microevolutionary scale for reflecting epidemiological drift of Entamoeba histolytica metapopulations. ( 27761718 )
2017
9
Penile amebiasis mimicking penile squamous cell carcinoma. ( 28083900 )
2017
10
Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica. ( 27242782 )
2016
11
Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution. ( 27795472 )
2016
12
Modulation of innate immune response by the vagus nerve in experimental hepatic amebiasis in rats. ( 27466057 )
2016
13
Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy. ( 27688666 )
2016
14
Prevalence of Entamoeba spp. in Stool Samples of Patients with Amebiasis Suspect by Native-Lugol and ELISA. ( 27594283 )
2016
15
Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis. ( 27764256 )
2016
16
Vaginal Amebiasis Mimicking Cervical Cancer. ( 27746453 )
2016
17
A Strong Correlation between the Annual Incidence of Amebiasis and Homosexual Human Immunodeficiency Virus Type Infection in Men. ( 26743150 )
2016
18
Entamoeba histolytica: Overexpression of the gal/galnac lectin, ehcp2 and ehcp5 genes in an in vivo model of amebiasis. ( 27616150 )
2016
19
Epidemiology of Domestically Acquired Amebiasis in Japan, 2000-2013. ( 26976888 )
2016
20
Primary Pulmonary Amebiasis Complicated with Multicystic Empyema. ( 27478673 )
2016
21
Neurologic amebiasis caused by Balamuthia mandrillaris in an Indian flying fox (Pteropus giganteus). ( 26762405 )
2016
22
Prevalence of amebiasis in inflammatory bowel disease in University Clinical Hospital Mostar. ( 27652159 )
2016
23
Amebic lung abscess with coexisting lung adenocarcinoma: a unusual case of amebiasis. ( 25550881 )
2014
24
Tropical dermatology: cutaneous larva migrans, gnathostomiasis, cutaneous amebiasis and trombiculiasis. ( 25577853 )
2014
25
Noninvasive intestinal amebiasis: Entamoeba histolytica colonization without invasion. ( 25101557 )
2014
26
Diffuse Hepatic Amebiasis Detected by FDG PET/CT. ( 25275416 )
2014
27
Subjective adverse reactions to metronidazole in patients with amebiasis. ( 24929036 )
2014
28
Laboratory diagnosis of amebiasis in a sample of students from southeastern Brazil and a comparison of microscopy with enzyme-linked immunosorbent assay for screening of infections with Entamoeba sp. ( 24603737 )
2014
29
Asymptomatic intestinal amebiasis in Japanese HIV-1-infected individuals. ( 25048374 )
2014
30
Amebiasis presenting as acute appendicitis: Report of a case and review of Japanese literature. ( 25460473 )
2014
31
Tissue destruction in amebiasis: chew on it. ( 25105188 )
2014
32
Colonoscopic diagnosis of amebiasis: a case series and systematic review. ( 25346004 )
2014
33
Host immune response to intestinal amebiasis. ( 23990778 )
2013
34
Intestinal amebiasis: a concerning cause of acute gastroenteritis among hospitalized lebanese children. ( 24404551 )
2013
35
Case report: Cutaneous amebiasis: the importance of molecular diagnosis of an emerging parasitic disease. ( 23208883 )
2013
36
Intestinal amebiasis in a group of patients with ulcerative colitis: influence on clinical course of the disease. ( 23678829 )
2013
37
An integrated microfluidic device for rapid serodiagnosis of amebiasis. ( 24403984 )
2013
38
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. ( 23775017 )
2013
39
Efficacy and safety of paromomycin for treating amebiasis in Japan. ( 23850836 )
2013
40
Unde venis? Amebiasis presenting as appendicitis. ( 24902389 )
2013
41
Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study. ( 23243179 )
2013
42
Cutaneous amebiasis: 50 years of experience. ( 23409482 )
2012
43
Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis. ( 22318340 )
2012
44
Amebiasis deaths in the United States. ( 22556095 )
2012
45
Clinical case of cerebral amebiasis caused by E. histolytica. ( 21870245 )
2012
46
An unusual cause of unilateral hydronephrosis: invasive colonic amebiasis. ( 22486169 )
2012
47
Diagnostic accuracy of indirect immunofluorescence assay for intestinal invasive amebiasis and impact of HIV infection in a non-endemic country. ( 23017259 )
2012
48
Entamoeba moshkovskii perspectives of a new agent to be considered in the diagnosis of amebiasis. ( 22664420 )
2012
49
The Entamoeba histolytica serum-inducible transmembrane kinase EhTMKB1-9 is involved in intestinal amebiasis. ( 23267432 )
2012
50
The dynamic interdependence of amebiasis, innate immunity, and undernutrition. ( 23114864 )
2012
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Variations for Amebiasis

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Expression for Amebiasis

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Search GEO for disease gene expression data for Amebiasis.
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Pathways for Amebiasis

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Pathways related to Amebiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Primary immunodeficiency 37
10.19 CD79A IGLL1
Sources

GO Terms for Amebiasis

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Cellular components related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 CD79A ICAM1 MYO1C
2 external side of plasma membrane GO:0009897 8.92 CD79A ICAM1 IGLL1 IL17A

Molecular functions related to Amebiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfilament motor activity GO:0000146 8.96 MYO1B MYO1C
2 actin-dependent ATPase activity GO:0030898 8.62 MYO1B MYO1C
Sources

Sources for Amebiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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