MCID: AML001
MIFTS: 38

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 11 14 16 75
Melanoma, Amelanotic 43 71
Amelanotic Skin Melanoma 71
Melanoma Amelanotic 53

Classifications:



External Ids:

Disease Ontology 11 DOID:4359
MeSH 43 D018328
NCIt 49 C3802
SNOMED-CT 68 70594002
UMLS 71 C0206735 C0349515

Summaries for Amelanotic Melanoma

MalaCards based summary: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to albinism and oculocutaneous albinism. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Neuroscience and Neural crest differentiation. Affiliated tissues include skin, lymph node and endothelial, and related phenotypes are pigmentation and normal

Wikipedia: 75 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin.: 696 They can... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 463)
# Related Disease Score Top Affiliating Genes
1 albinism 30.8 TYRP1 TYR MITF DCT
2 oculocutaneous albinism 30.3 TYRP1 TYR MITF MC1R LAMP1 DCT
3 albinism, oculocutaneous, type ia 30.2 TYRP1 TYR MC1R
4 malignant skin fibrous histiocytoma 30.2 NRAS MLANA KIT
5 skin melanoma 30.2 TYR NRAS MLANA MITF MC1R KIT
6 vitiligo-associated multiple autoimmune disease susceptibility 1 30.2 TYRP1 TYR MLANA MITF MC1R DCT
7 hermansky-pudlak syndrome 30.1 TYRP1 TYR LAMP1 DCT
8 mesenchymal cell neoplasm 30.0 SERPINA3 MLANA KIT
9 well-differentiated liposarcoma 30.0 SERPINA3 MLANA KIT
10 malignant peripheral nerve sheath tumor 30.0 SOX10 S100B MITF KIT
11 fibrous histiocytoma 30.0 SOX10 SERPINA3 S100B MLANA MITF
12 malignant conjunctival melanoma 30.0 NRAS MLANA KIT
13 mucosal melanoma 29.9 TYR SOX10 NRAS MLANA MITF KIT
14 olfactory neuroblastoma 29.9 SYP S100B ENO2
15 ocular melanoma 29.8 TYR NRAS MLANA MITF MC1R KIT
16 acral lentiginous melanoma 29.7 TYR NRAS MLANA MITF MC1R KIT
17 basal cell carcinoma 29.7 TYR SYP MC1R KRT20 ENO2
18 rhabdomyosarcoma 2 29.7 SYP KIT ENO2
19 spindle cell sarcoma 29.6 SOX10 SERPINA3 S100B MLANA KIT
20 nodular malignant melanoma 29.6 TYR SOX10 NRAS MLANA MITF MC1R
21 large congenital melanocytic nevus 29.6 SOX10 NRAS MLANA MITF MC1R
22 skin benign neoplasm 29.6 TYR SERPINA3 MLANA KRT20 ENO2
23 cystic teratoma 29.5 SYP KRT20 ENO2
24 neuroendocrine tumor 29.5 SYP KRT20 ENO2
25 rhabdomyosarcoma 29.3 SYP S100B NRAS KIT ENO2
26 cystadenoma 29.2 SYP SERPINA3 KRT20 KIT
27 melanoma in congenital melanocytic nevus 29.2 TYR SOX10 S100B NRAS MLANA MITF
28 malignant spindle cell melanoma 29.2 TYR SOX10 SERPINA3 NRAS MLANA MITF
29 teratoma 29.1 SYP KRT20 KIT ENO2
30 merkel cell carcinoma 29.1 SYP KRT20 KIT ENO2
31 microphthalmia 29.1 TYRP1 TYR SOX10 S100B MLANA MITF
32 melanoma, uveal 29.1 TYR SOX10 S100B NRAS MLANA MITF
33 melanoma, cutaneous malignant 1 29.0 TYRP1 TYR SOX10 NRAS MLANA MITF
34 melanoma 29.0 TYRP1 TYR SOX10 S100B OSM NRAS
35 gastrointestinal stromal tumor 28.9 SYP SOX10 SERPINA3 S100B NRAS MLANA
36 skin carcinoma 28.8 TYRP1 TYR SYP NRAS MLANA MITF
37 neurilemmoma 28.8 TYR SYP SOX10 SERPINA3 S100B MLANA
38 skin amelanotic melanoma 11.4
39 ciliary body cancer 10.4 TYR MLANA
40 melanoacanthoma 10.4 TYR MLANA
41 diffuse meningeal melanocytosis 10.4 TYR MLANA
42 sarcomatoid transitional cell carcinoma 10.3 TYR MLANA
43 melanoma, cutaneous malignant 8 10.3 TYR MITF
44 melanomatosis 10.3 NRAS MLANA
45 conventional leiomyosarcoma 10.3 MLANA MITF
46 pigmented basal cell carcinoma 10.3 MLANA MITF
47 acute contagious conjunctivitis 10.3 TYRP1 TYR DCT
48 conjunctival pigmentation 10.3 SOX10 MLANA
49 epithelioid type angiomyolipoma 10.3 MLANA MITF
50 penis sarcoma 10.3 MLANA ENO2

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

GenomeRNAi Phenotypes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.11 ANXA5 DCT ENO2 KIT KRT20 LAMP1
2 no effect GR00402-S-2 10.11 ANXA5 DCT KIT MLANA NRAS OSM

MGI Mouse Phenotypes related to Amelanotic Melanoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 10.06 DCT KIT MC1R MITF MLANA NRAS
2 normal MP:0002873 10.02 ANXA5 KIT LAMP1 MITF NRAS S100B
3 no phenotypic analysis MP:0003012 9.87 KIT MC1R MITF MLANA NRAS SOX10
4 limbs/digits/tail MP:0005371 9.8 ANXA5 KIT MC1R MITF NRAS SOX10
5 craniofacial MP:0005382 9.76 ENO2 KIT LAMP1 MC1R MITF NRAS
6 behavior/neurological MP:0005386 9.73 ENO2 KIT MC1R MITF NRAS OSM
7 integument MP:0010771 9.47 DCT KIT LAMP1 MC1R MITF MLANA

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials, NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cisplatin
CISPLATIN PWDR

Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

Organs/tissues related to Amelanotic Melanoma:

MalaCards : Skin, Lymph Node, Endothelial, Lung, Cervix, Tongue, Breast

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 917)
# Title Authors PMID Year
1
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. 53 62
19133143 2009
2
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: effects of altering intracellular pH and pink-eyed dilution gene expression. 53 62
16199032 2006
3
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. 53 62
16584089 2006
4
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. 53 62
16087843 2005
5
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. 53 62
14634018 2004
6
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport. 53 62
12190873 2002
7
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. 53 62
11812790 2002
8
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. 53 62
11775059 2001
9
Translation rate of human tyrosinase determines its N-linked glycosylation level. 53 62
11069924 2001
10
Sensitivity of transplantable melanoma cells to cytokines with regard to their spontaneous apoptosis. 53 62
12107342 2001
11
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. 53 62
10890385 2000
12
Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V. 53 62
10763124 2000
13
Inhibition of melanin synthesis by cystamine in human melanoma cells. 53 62
10620110 2000
14
Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. 53 62
10381529 1999
15
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. 53 62
9877098 1998
16
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. 53 62
9177196 1997
17
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. 53 62
7535606 1994
18
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs. 53 62
7886004 1994
19
Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. 53 62
8008452 1994
20
Malignant melanoma of the nasal cavity. 53 62
7779028 1994
21
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy. 53 62
8110729 1994
22
Amelanotic melanoma of the oral cavity. 53 62
8410206 1993
23
Tyrosinase gene transcription and its control by melanogenic inhibitors. 53 62
8433001 1993
24
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma. 53 62
8433011 1993
25
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. 53 62
1782361 1991
26
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells. 53 62
1903481 1991
27
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. 53 62
2200526 1990
28
Primary intracranial melanoma, amelanotic variant: Case report. 62
35248502 2022
29
Molecular Events in the Melanogenesis Cascade as Novel Melanoma-Targeted Small Molecules: Principle and Development. 62
36428680 2022
30
Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome. 62
35990226 2022
31
Recurrent Significant Bleeding From Abdominal Wall Giant Pyogenic Granuloma Requiring Multiple Blood Transfusions. 62
36225485 2022
32
Examining the prevalence and incidence of amelanotic melanoma in two Irish Hospitals. 62
35768292 2022
33
Acral Amelanotic Melanoma Mimicking a Foot Ulcer. 62
35936139 2022
34
Oral Amelanotic Melanoma: A Systematic Review of Case Reports and Case Series. 62
34309791 2022
35
Subungual Exostosis Presenting as a Pyogenic Granuloma-like Lesion with Reactive Myofibroblastic Proliferation in Two Young Women. 62
35735660 2022
36
Fine-needle aspiration cytological findings in three cases of metastatic amelanotic melanoma to the parotid gland with divergent differentiation. 62
34951742 2022
37
The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32). 62
35059971 2022
38
Insidious ocular surface lesion in an 81-year-old woman. 62
35246440 2022
39
[Plantar melanoma: A wolf in sheep's clothing]. 62
35291043 2022
40
Amelanotic melanoma of the palate: report of a case. 62
35354566 2022
41
Dermoscopy for the Identification of Amelanotic Acral Melanoma. 62
36459055 2022
42
Amelanotic melanoma with features of keratinocytic tumor on reflectance confocal microscopy. 62
34904749 2022
43
Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer. 62
34433708 2022
44
Amelanotic melanoma of the nail apparatus complicated with digital mucous cyst. 62
34374431 2022
45
Amelanotic nodular melanoma misdiagnosed as a benign skin lesion: A rare case report from Syria. 62
35145679 2022
46
Eruptive melanocytic nevi in a patient with amelanotic melanoma: a paraneoplastic phenomenon? 62
34725315 2022
47
Amelanotic Melanoma Treated as Fungal Infection for Years. 62
36386569 2022
48
Correction to: Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment. 62
35129544 2022
49
Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment. 62
35116218 2022
50
Anorectal malignant amelanotic melanoma: Report of a rare aggressive primary tumor. 62
35381792 2022

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.2 SYP SLC4A1 S100B ENO2
2 11.5 SOX10 MITF DCT
3 11.33 SYP SOX10 S100B
4 11.07 SOX10 MITF MC1R KIT
5 10.55 TYRP1 TYR MLANA MITF MC1R DCT
6 9.83 TYRP1 TYR DCT

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 9.43 TYRP1 TYR DCT
2 melanosome GO:0042470 9.32 TYRP1 TYR MLANA LAMP1 DCT

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanocyte differentiation GO:0030318 9.76 TYRP1 SOX10 MITF KIT
2 response to blue light GO:0009637 9.62 TYR DCT
3 melanin biosynthetic process from tyrosine GO:0006583 9.56 TYR DCT
4 melanin biosynthetic process GO:0042438 9.5 TYRP1 TYR MC1R DCT
5 pigmentation GO:0043473 9.28 TYRP1 TYR MITF MC1R KIT DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tyrosinase activity GO:0004503 8.92 TYRP1 TYR

Sources for Amelanotic Melanoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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