MCID: AML001
MIFTS: 41

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15
Melanoma, Amelanotic 44 73
Amelanotic Skin Melanoma 73
Melanoma Amelanotic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 44 D018328
NCIt 50 C3802
SNOMED-CT 68 70594002

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to malignant skin fibrous histiocytoma and acral lentiginous melanoma. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Cushing syndrome and Detoxification of Reactive Oxygen Species. Affiliated tissues include skin, lung and colon, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be pink,... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 malignant skin fibrous histiocytoma 30.2 KIT TYR
2 acral lentiginous melanoma 30.0 BRAF KIT
3 gastrointestinal stromal tumor 29.6 BRAF KIT S100B VIM
4 skin amelanotic melanoma 12.3
5 melanoma 11.1
6 albinism 10.4
7 oculocutaneous albinism 10.3
8 malignant spindle cell melanoma 10.2 KIT TYR
9 breast angiosarcoma 10.2 KIT TYR
10 reticular perineurioma 10.2 KIT S100B
11 mixed type thymoma 10.2 KIT S100B
12 aggressive digital papillary adenocarcinoma 10.2 KIT S100B
13 adenocarcinoma 10.2
14 lentigo maligna melanoma 10.2
15 pyogenic granuloma 10.2
16 vulvar melanoma 10.2 KIT TYR
17 albinism, oculocutaneous, type ii 10.2 TYR TYRP1
18 albinism, oculocutaneous, type iii 10.2 TYR TYRP1
19 malignant dermis tumor 10.2 KIT TYR
20 hydromyelia 10.1 S100B VIM
21 albinism, oculocutaneous, type ib 10.1 TYR TYRP1
22 gonadoblastoma 10.1 CAT KIT
23 central nervous system melanocytic neoplasm 10.1 KIT TYR
24 bednar tumor 10.1 S100B VIM
25 primary hepatic neuroendocrine carcinoma 10.1 S100B VIM
26 albinism, oculocutaneous, type v 10.1 TYR TYRP1
27 ossifying fibromyxoid tumor 10.1 S100B VIM
28 fibrous meningioma 10.1 S100B VIM
29 chordoid meningioma 10.1 S100B VIM
30 eccrine porocarcinoma 10.1 S100B VIM
31 albinism, oculocutaneous, type vii 10.1 TYR TYRP1
32 myxopapillary ependymoma 10.1 S100B VIM
33 ependymoma 10.1 S100B VIM
34 monophasic synovial sarcoma 10.1 S100B VIM
35 spiradenoma 10.1 S100B VIM
36 albinism, oculocutaneous, type ia 10.1 TYR TYRP1
37 syringoma 10.1 S100B VIM
38 mast-cell sarcoma 10.1 KIT VIM
39 angiocentric glioma 10.1 S100B VIM
40 benign breast phyllodes tumor 10.1 KIT VIM
41 pleomorphic liposarcoma 10.1 S100B VIM
42 cutaneous fibrous histiocytoma 10.1 S100B VIM
43 fibrous histiocytoma 10.1 S100B VIM
44 angiomyolipoma 10.1 KIT TYR
45 anaplastic ependymoma 10.1 S100B VIM
46 cystic nephroma 10.1 KIT VIM
47 hermansky-pudlak syndrome 3 10.1 TYR TYRP1
48 angiosarcoma 10.1 KIT VIM
49 spindle cell sarcoma 10.1 S100B VIM
50 odontogenic myxoma 10.1 S100B VIM

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.98 BRAF CYCS KIT S100B TYR TYRP1
2 cellular MP:0005384 9.95 BRAF CAT CYCS KIT TYR TYRP1
3 mortality/aging MP:0010768 9.86 BRAF CAT CTSG CYCS KIT TYR
4 craniofacial MP:0005382 9.77 BRAF CYCS KIT TYR TYRP1
5 neoplasm MP:0002006 9.63 BRAF CAT CTSG KIT TYR TYRP1
6 hearing/vestibular/ear MP:0005377 9.62 BRAF KIT TYR TYRP1
7 pigmentation MP:0001186 9.26 BRAF KIT TYR TYRP1
8 vision/eye MP:0005391 9.02 BRAF KIT TYR TYRP1 VIM

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

41
Skin, Lung, Colon, Bone, Breast, Smooth Muscle, Pineal

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 263)
# Title Authors Year
1
Unsuspected Amelanotic Melanoma in an Elephantiasis Foot. ( 29854646 )
2018
2
Amelanotic melanoma: a unique case study and review of the literature. ( 29602781 )
2018
3
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. ( 28976625 )
2018
4
Amelanotic melanoma. ( 29545447 )
2018
5
Subungual Amelanotic Melanoma Masquerading as Onychomycosis. ( 29755903 )
2018
6
Noninvasive Gene Expression Testing in Amelanotic Melanoma. ( 29238803 )
2018
7
Multiple cutaneous metastases of amelanotic melanoma. ( 30050605 )
2018
8
Amelanotic melanoma arising in an area of SLURP-1 mutated Mal de Meleda. ( 30246339 )
2018
9
Melanization of Bomirski hamster amelanotic melanoma cells (Ab line) depends on the type of culture medium. ( 30370913 )
2018
10
Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma. ( 30474018 )
2018
11
Unexpected amelanotic melanoma simulators. ( 28106946 )
2017
12
Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study. ( 28555837 )
2017
13
Congenital amelanotic melanoma in a crossbred heifer calf. ( 28423984 )
2017
14
Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution. ( 29166513 )
2017
15
Proteasome inhibitors against amelanotic melanoma. ( 28281027 )
2017
16
An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings. ( 29141067 )
2017
17
Amelanotic Melanoma Arising in Filarial Leg: A Report of a Rare Case. ( 28273977 )
2017
18
Amelanotic melanoma in a child, the importance of suspecting the disease. ( 28636079 )
2017
19
A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report. ( 28171845 )
2017
20
Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. ( 28623530 )
2017
21
Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. ( 28746718 )
2017
22
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. ( 27206673 )
2016
23
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. ( 26949998 )
2016
24
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma. ( 27064601 )
2016
25
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
26
Presentation of a patient with in situ amelanotic melanoma of the vulva. ( 29894090 )
2016
27
Amelanotic melanoma in the bone marrow. ( 28092878 )
2016
28
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis. ( 27206672 )
2016
29
Amelanotic melanoma in albinism: the power of dermatoscopy. ( 26290313 )
2015
30
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader. ( 26348327 )
2015
31
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation. ( 26266008 )
2015
32
Intracranial amelanotic melanoma: a case report with literature review. ( 25963017 )
2015
33
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. ( 26204672 )
2015
34
BILATERALLY SYMMETRICAL ORAL AMELANOTIC MELANOMA IN A BOA CONSTRICTOR (BOA CONSTRICTOR CONSTRICTOR). ( 26352976 )
2015
35
Metastatic amelanotic melanoma with occult primary masquerading as sarcoma. ( 25859510 )
2015
36
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. ( 25500029 )
2015
37
Polarized light dermoscopy to aid in the diagnosis of new pink lesions in an amelanotic melanoma survivor. ( 26568348 )
2015
38
Amelanotic melanoma mimicking an atypical fibrohistiocytic lesion. ( 25993406 )
2015
39
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento. ( 26498081 )
2015
40
Primary central nervous system amelanotic melanoma in a Hispanic male: Case report. ( 25031666 )
2014
41
Amelanotic melanoma mimicking cutaneous epitheliomas. ( 24629365 )
2014
42
Amelanotic melanoma masquerading as a pyogenic granuloma: caution warranted. ( 24914083 )
2014
43
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. ( 24393566 )
2014
44
Oral amelanotic melanoma of the maxilla. ( 25628704 )
2014
45
Amelanotic melanoma masquerading as a superficial small round cell tumor: a diagnostic challenge. ( 25484414 )
2014
46
Amelanotic melanoma: a case with chr 9 monosomy. ( 24965431 )
2014
47
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. ( 24915302 )
2014
48
Primary amelanotic melanoma of the nasal cavity: a case report. ( 24452896 )
2014
49
PRIMARY MALIGNANT AMELANOTIC MELANOMA ARISING FROM A VITILIGO PATCH OF AN AFRICAN TANZANIAN: CASE REPORT. ( 26866119 )
2014
50
Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges. ( 23591855 )
2013

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 BRAF KIT TYR TYRP1
2
Show member pathways
10.9 CAT CYCS
3 9.65 TYR TYRP1

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.62 TYR TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.71 CAT CYCS TYR TYRP1
2 somatic stem cell population maintenance GO:0035019 9.52 BRAF KIT
3 response to cAMP GO:0051591 9.51 BRAF TYR
4 response to UV GO:0009411 9.49 CAT TYR
5 visual learning GO:0008542 9.48 BRAF KIT
6 long-term synaptic potentiation GO:0060291 9.46 BRAF S100B
7 thymus development GO:0048538 9.43 BRAF TYR
8 response to radiation GO:0009314 9.37 CAT KIT
9 response to cadmium ion GO:0046686 9.32 CAT KIT
10 melanocyte differentiation GO:0030318 9.26 KIT TYRP1
11 melanin biosynthetic process GO:0042438 9.16 TYR TYRP1
12 myeloid progenitor cell differentiation GO:0002318 8.96 BRAF KIT
13 pigmentation GO:0043473 8.8 KIT TYR TYRP1

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.5 BRAF CAT CYCS KIT S100B TYR
2 protein homodimerization activity GO:0042803 9.02 CAT KIT S100B TYR TYRP1

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....