MCID: AML001
MIFTS: 38

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 44 72
Amelanotic Skin Melanoma 72
Melanoma Amelanotic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 44 D018328
NCIt 50 C3802
SNOMED-CT 68 70594002
UMLS 72 C0206735 C0349515

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to malignant skin fibrous histiocytoma and acral lentiginous melanoma. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways is Melanin biosynthesis. Affiliated tissues include skin, lung and testes, and related phenotypes are Strongly decreased CFP-tsO45G cell surface transport and integument

Wikipedia : 75 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 malignant skin fibrous histiocytoma 30.8 TYR KIT
2 acral lentiginous melanoma 30.6 KIT BRAF
3 neurilemmoma 30.5 S100B KIT
4 mucosal melanoma 30.4 KIT BRAF
5 melanoma, uveal 30.2 TYR S100B BRAF
6 vitiligo-associated multiple autoimmune disease susceptibility 1 30.2 TYRP1 TYR
7 vitiligo-associated multiple autoimmune disease susceptibility 6 30.0 TYRP1 TYR CAT
8 albinism, oculocutaneous, type ia 30.0 TYRP1 TYR
9 gastrointestinal stromal tumor 29.8 S100B KIT BRAF
10 microphthalmia 28.8 TYRP1 TYR KIT DCT
11 skin amelanotic melanoma 12.4
12 melanoma 11.1
13 malignant spindle cell melanoma 10.5 TYR KIT
14 breast angiosarcoma 10.5 TYR KIT
15 reticular perineurioma 10.5 S100B KIT
16 perineurioma 10.5 S100B KIT
17 mixed type thymoma 10.5 S100B KIT
18 aggressive digital papillary adenocarcinoma 10.5 S100B KIT
19 vulvar melanoma 10.4 TYR KIT
20 skin melanoma 10.4
21 malignant dermis tumor 10.4 TYR KIT
22 functioning pituitary adenoma 10.4 S100B DRD2
23 polymorphous low-grade adenocarcinoma 10.4 S100B KIT
24 albinism 10.4
25 gonadoblastoma 10.4 KIT CAT
26 central nervous system melanocytic neoplasm 10.4 TYR KIT
27 angiomyolipoma 10.3 TYR KIT
28 traumatic brain injury 10.3 S100B DRD2
29 brain injury 10.3 S100B DRD2
30 oculocutaneous albinism 10.3
31 basal cell carcinoma 10.3
32 skin carcinoma 10.3
33 cutaneous fibrous histiocytoma 10.3 SERPINA3 S100B
34 fibrous histiocytoma 10.3 SERPINA3 S100B
35 odontogenic myxoma 10.3 SERPINA3 S100B
36 granular cell tumor 10.3 SERPINA3 S100B
37 cutaneous solitary mastocytoma 10.3 SERPINA3 KIT
38 lentigines 10.3
39 nodular malignant melanoma 10.3
40 pyogenic granuloma 10.3
41 rare tumor 10.3
42 myopericytoma 10.2 S100B BRAF
43 neurofibroma 10.2 S100B KIT
44 juvenile xanthogranuloma 10.2 S100B BRAF
45 malignant iris melanoma 10.2
46 malignant fibroxanthoma 10.2 SERPINA3 S100B
47 fibrosarcoma of bone 10.2 SERPINA3 KIT
48 mastocytosis, cutaneous 10.2 KIT CTSG
49 clear cell sarcoma 10.1 S100B KIT
50 ovarian cancer 10.1

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

GenomeRNAi Phenotypes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-2 8.92 CTSG DCT DRD2 KIT

MGI Mouse Phenotypes related to Amelanotic Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.8 BRAF DCT DRD2 KIT S100B TYR
2 neoplasm MP:0002006 9.7 BRAF CAT CTSG DRD2 KIT TYR
3 hearing/vestibular/ear MP:0005377 9.62 BRAF KIT TYR TYRP1
4 normal MP:0002873 9.43 BRAF CTSG DRD2 KIT S100B TYR
5 pigmentation MP:0001186 9.1 BRAF DCT DRD2 KIT TYR TYRP1

Drugs & Therapeutics for Amelanotic Melanoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cisplatin
CISPLATIN PWDR

Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

41
Skin, Lung, Testes, Lymph Node, Endothelial, Brain, Colon

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 815)
# Title Authors PMID Year
1
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. 9 38
19133143 2009
2
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: effects of altering intracellular pH and pink-eyed dilution gene expression. 9 38
16199032 2006
3
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. 9 38
16584089 2006
4
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. 9 38
16087843 2005
5
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. 9 38
14634018 2004
6
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport. 9 38
12190873 2002
7
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. 9 38
11812790 2002
8
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. 9 38
11775059 2001
9
Translation rate of human tyrosinase determines its N-linked glycosylation level. 9 38
11069924 2001
10
Sensitivity of transplantable melanoma cells to cytokines with regard to their spontaneous apoptosis. 9 38
12107342 2001
11
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. 9 38
10890385 2000
12
Inhibition of melanin synthesis by cystamine in human melanoma cells. 9 38
10620110 2000
13
Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V. 9 38
10763124 2000
14
Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. 9 38
10381529 1999
15
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. 9 38
9877098 1998
16
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. 9 38
9177196 1997
17
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. 9 38
7535606 1994
18
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs. 9 38
7886004 1994
19
Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. 9 38
8008452 1994
20
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy. 9 38
8110729 1994
21
Malignant melanoma of the nasal cavity. 9 38
7779028 1994
22
Amelanotic melanoma of the oral cavity. 9 38
8410206 1993
23
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma. 9 38
8433011 1993
24
Tyrosinase gene transcription and its control by melanogenic inhibitors. 9 38
8433001 1993
25
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. 9 38
1782361 1991
26
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells. 9 38
1903481 1991
27
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. 9 38
2200526 1990
28
Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method. 38
30985194 2019
29
Reflectance confocal microscopy margin mapping and monitoring of an amelanotic melanoma in situ of the ear. 38
30592021 2019
30
Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. 38
31432325 2019
31
Amelanotic melanoma arising in an area of SLURP-1 mutated Mal de Meleda. 38
30246339 2019
32
Dermoscopy of primary cutaneous B- and T-cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case-control study with histopathologic correlation. 38
31347153 2019
33
Amelanotic melanoma. 38
30672881 2019
34
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. 38
31172223 2019
35
Recurrent amelanotic melanoma of nasal cavity: Biological variability and unpredictable behavior of mucosal melanoma. A case report. 38
31285816 2019
36
Fixed oil from seeds of narrow-leaved ash (F. angustifolia subsp. angustifolia): Chemical profile, antioxidant and antiproliferative activities. 38
30884667 2019
37
Choroidal amelanotic tumours: clinical differentiation of benign from malignant lesions in 5586 cases. 38
31023712 2019
38
Iris melanoma relapsing sixteen years after proton-beam therapy: The importance of lifelong follow-up. 38
30619969 2019
39
[Mucosal melanoma primary and metastatic cases with urogenital localization in our department]. 38
30829059 2019
40
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA. 38
30908472 2019
41
Multiple bone metastases from an amelanotic melanoma of unknown primary origin. 38
30848028 2019
42
Metastatic amelanotic melanoma with cardiac involvement: A case report. 38
31193670 2019
43
Amelanotic iris melanoma in a 7 year-old hispanic boy with subclinical globe perforation. 38
30342820 2019
44
Dermoscopy improves diagnostic accuracy for clinically amelanotic nodules. 38
30123971 2019
45
Novel therapeutic compound acridine-retrotuftsin action on biological forms of melanoma and neuroblastoma. 38
30367436 2019
46
Acral Amelanotic Melanoma Mimicking a Non-Healing Arterial Ulcer. 38
31097933 2019
47
Amelanotic acral melanoma misdiagnosed as verruca plantaris. 38
30726470 2019
48
A pink enlarging plaque on the plantar foot: amelanotic acral lentiginous melanoma. 38
30710904 2019
49
Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma. 38
30474018 2018
50
[Intraocular melanoma in a 10-year-old female llama (Lama glama)]. 38
30340243 2018

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.5 TYRP1 TYR DCT

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 9.13 TYRP1 TYR DCT
2 melanosome membrane GO:0033162 8.8 TYRP1 TYR DCT

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 TYRP1 TYR DCT CAT
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.69 KIT DRD2 BRAF
3 somatic stem cell population maintenance GO:0035019 9.58 KIT BRAF
4 response to UV GO:0009411 9.57 TYR CAT
5 response to cAMP GO:0051591 9.56 TYR BRAF
6 long-term synaptic potentiation GO:0060291 9.55 S100B BRAF
7 thymus development GO:0048538 9.54 TYR BRAF
8 visual learning GO:0008542 9.5 KIT DRD2 BRAF
9 response to radiation GO:0009314 9.49 KIT CAT
10 response to cadmium ion GO:0046686 9.48 KIT CAT
11 positive regulation of neuroblast proliferation GO:0002052 9.46 DRD2 DCT
12 melanocyte differentiation GO:0030318 9.43 TYRP1 KIT
13 developmental pigmentation GO:0048066 9.4 KIT DCT
14 myeloid progenitor cell differentiation GO:0002318 9.37 KIT BRAF
15 response to inactivity GO:0014854 9.26 DRD2 CAT
16 melanin biosynthetic process from tyrosine GO:0006583 9.16 TYR DCT
17 melanin biosynthetic process GO:0042438 9.13 TYRP1 TYR DCT
18 pigmentation GO:0043473 9.02 TYRP1 TYR KIT DRD2 DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.8 TYRP1 TYR S100B KIT DCT CAT
2 oxidoreductase activity GO:0016491 9.46 TYRP1 TYR DCT CAT
3 protein heterodimerization activity GO:0046982 9.26 TYRP1 TYR DRD2 BRAF
4 protein homodimerization activity GO:0042803 9.1 TYRP1 TYR S100B KIT DRD2 CAT

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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