MCID: AML001
MIFTS: 40

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 45 74
Amelanotic Skin Melanoma 74
Melanoma Amelanotic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 45 D018328
NCIt 51 C3802
SNOMED-CT 69 70594002

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to acral lentiginous melanoma and vitiligo-associated multiple autoimmune disease susceptibility 1. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways is Melanin biosynthesis. Affiliated tissues include skin, brain and bone, and related phenotypes are Strongly decreased CFP-tsO45G cell surface transport and integument

Wikipedia : 77 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 acral lentiginous melanoma 30.2 KIT BRAF
2 vitiligo-associated multiple autoimmune disease susceptibility 1 30.1 TYRP1 TYR
3 gastrointestinal stromal tumor 29.9 S100B KIT BRAF
4 skin amelanotic melanoma 12.3
5 melanoma 11.2
6 albinism 10.4
7 malignant spindle cell melanoma 10.3 TYR KIT
8 breast angiosarcoma 10.3 TYR KIT
9 oculocutaneous albinism 10.3
10 reticular perineurioma 10.3 S100B KIT
11 perineurioma 10.3 KIT S100B
12 mixed type thymoma 10.3 S100B KIT
13 aggressive digital papillary adenocarcinoma 10.3 S100B KIT
14 vulvar melanoma 10.3 TYR KIT
15 malignant skin fibrous histiocytoma 10.3 TYR KIT
16 malignant dermis tumor 10.3 TYR KIT
17 polymorphous low-grade adenocarcinoma 10.2 S100B KIT
18 gonadoblastoma 10.2 KIT CAT
19 central nervous system melanocytic neoplasm 10.2 TYR KIT
20 angiomyolipoma 10.2 TYR KIT
21 functioning pituitary adenoma 10.2 DRD2 S100B
22 myopericytoma 10.2 S100B BRAF
23 juvenile xanthogranuloma 10.2 S100B BRAF
24 adenocarcinoma 10.2
25 lentigo maligna melanoma 10.2
26 pyogenic granuloma 10.2
27 traumatic brain injury 10.2 S100B DRD2
28 cutaneous fibrous histiocytoma 10.2 S100B SERPINA3
29 brain injury 10.2 S100B DRD2
30 fibrous histiocytoma 10.2 SERPINA3 S100B
31 odontogenic myxoma 10.2 S100B SERPINA3
32 cutaneous solitary mastocytoma 10.2 KIT SERPINA3
33 granular cell tumor 10.2 SERPINA3 S100B
34 mucosal melanoma 10.1 KIT BRAF
35 neurilemmoma 10.1 KIT S100B
36 malignant fibroxanthoma 10.1 SERPINA3 S100B
37 fibrosarcoma of bone 10.1 SERPINA3 KIT
38 ovarian cancer 10.1
39 melanoma metastasis 10.1
40 neurofibroma 10.1 KIT S100B
41 piebald trait 10.1 KIT TYR
42 erdheim-chester disease 10.1 SERPINA3 BRAF
43 ganglioglioma 10.1 BRAF S100B
44 albinism, oculocutaneous, type ii 10.1 TYRP1 TYR
45 albinism, oculocutaneous, type iii 10.1 TYRP1 TYR
46 albinism, oculocutaneous, type ib 10.0 TYRP1 TYR
47 albinism, oculocutaneous, type v 10.0 TYRP1 TYR
48 melanoma, uveal 10.0 TYR S100B BRAF
49 clear cell sarcoma 10.0 KIT S100B
50 connective tissue cancer 10.0 KIT SERPINA3

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

GenomeRNAi Phenotypes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-2 8.92 CTSG DCT DRD2 KIT

MGI Mouse Phenotypes related to Amelanotic Melanoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.8 BRAF DCT DRD2 KIT S100B TYR
2 neoplasm MP:0002006 9.7 BRAF CAT CTSG DRD2 KIT TYR
3 hearing/vestibular/ear MP:0005377 9.62 BRAF KIT TYR TYRP1
4 normal MP:0002873 9.43 BRAF CTSG DRD2 KIT S100B TYR
5 pigmentation MP:0001186 9.1 BRAF DCT DRD2 KIT TYR TYRP1

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

42
Skin, Brain, Bone, Colon, Breast, Lung, Pituitary

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 270)
# Title Authors Year
1
Amelanotic melanoma. ( 30672881 )
2019
2
Multiple bone metastases from an amelanotic melanoma of unknown primary origin. ( 30848028 )
2019
3
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA. ( 30908472 )
2019
4
Acral Amelanotic Melanoma Mimicking a Non-Healing Arterial Ulcer. ( 31097933 )
2019
5
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. ( 28976625 )
2018
6
Noninvasive Gene Expression Testing in Amelanotic Melanoma. ( 29238803 )
2018
7
Amelanotic melanoma. ( 29545447 )
2018
8
Amelanotic melanoma: a unique case study and review of the literature. ( 29602781 )
2018
9
Subungual Amelanotic Melanoma Masquerading as Onychomycosis. ( 29755903 )
2018
10
Unsuspected Amelanotic Melanoma in an Elephantiasis Foot. ( 29854646 )
2018
11
Multiple cutaneous metastases of amelanotic melanoma. ( 30050605 )
2018
12
Amelanotic melanoma arising in an area of SLURP-1 mutated Mal de Meleda. ( 30246339 )
2018
13
Melanization of Bomirski hamster amelanotic melanoma cells (Ab line) depends on the type of culture medium. ( 30370913 )
2018
14
Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma. ( 30474018 )
2018
15
Reflectance confocal microscopy margin mapping and monitoring of an amelanotic melanoma in situ of the ear. ( 30592021 )
2018
16
Polypoid amelanotic melanoma: a diagnostic challenge. ( 30677854 )
2018
17
Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study. ( 28555837 )
2017
18
Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. ( 28746718 )
2017
19
An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings. ( 29141067 )
2017
20
Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution. ( 29166513 )
2017
21
Unexpected amelanotic melanoma simulators. ( 28106946 )
2017
22
A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report. ( 28171845 )
2017
23
Amelanotic Melanoma Arising in Filarial Leg: A Report of a Rare Case. ( 28273977 )
2017
24
Proteasome inhibitors against amelanotic melanoma. ( 28281027 )
2017
25
Congenital amelanotic melanoma in a crossbred heifer calf. ( 28423984 )
2017
26
Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. ( 28623530 )
2017
27
Amelanotic melanoma in a child, the importance of suspecting the disease. ( 28636079 )
2017
28
Amelanotic melanoma in albinism: the power of dermatoscopy. ( 26290313 )
2016
29
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader. ( 26348327 )
2016
30
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. ( 26949998 )
2016
31
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
32
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma. ( 27064601 )
2016
33
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis. ( 27206672 )
2016
34
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. ( 27206673 )
2016
35
Amelanotic melanoma in the bone marrow. ( 28092878 )
2016
36
Presentation of a patient with in situ amelanotic melanoma of the vulva. ( 29894090 )
2016
37
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. ( 24393566 )
2015
38
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. ( 25500029 )
2015
39
Metastatic amelanotic melanoma with occult primary masquerading as sarcoma. ( 25859510 )
2015
40
Intracranial amelanotic melanoma: a case report with literature review. ( 25963017 )
2015
41
Amelanotic melanoma mimicking an atypical fibrohistiocytic lesion. ( 25993406 )
2015
42
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. ( 26204672 )
2015
43
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation. ( 26266008 )
2015
44
BILATERALLY SYMMETRICAL ORAL AMELANOTIC MELANOMA IN A BOA CONSTRICTOR (BOA CONSTRICTOR CONSTRICTOR). ( 26352976 )
2015
45
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento. ( 26498081 )
2015
46
Polarized light dermoscopy to aid in the diagnosis of new pink lesions in an amelanotic melanoma survivor. ( 26568348 )
2015
47
Primary amelanotic melanoma of the breast: combating a rare cancer. ( 20978954 )
2014
48
Hyporeflective pagetoid cells: a new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. ( 24329036 )
2014
49
Primary amelanotic melanoma of the nasal cavity: a case report. ( 24452896 )
2014
50
Amelanotic melanoma mimicking cutaneous epitheliomas. ( 24629365 )
2014

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.5 DCT TYR TYRP1

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 9.13 DCT TYR TYRP1
2 melanosome membrane GO:0033162 8.8 DCT TYR TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 CAT DCT TYR TYRP1
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.69 BRAF DRD2 KIT
3 somatic stem cell population maintenance GO:0035019 9.58 BRAF KIT
4 response to cAMP GO:0051591 9.57 BRAF TYR
5 response to UV GO:0009411 9.56 CAT TYR
6 long-term synaptic potentiation GO:0060291 9.55 BRAF S100B
7 thymus development GO:0048538 9.54 BRAF TYR
8 visual learning GO:0008542 9.5 BRAF DRD2 KIT
9 response to radiation GO:0009314 9.49 CAT KIT
10 response to cadmium ion GO:0046686 9.48 CAT KIT
11 positive regulation of neuroblast proliferation GO:0002052 9.46 DCT DRD2
12 melanocyte differentiation GO:0030318 9.43 KIT TYRP1
13 developmental pigmentation GO:0048066 9.4 DCT KIT
14 myeloid progenitor cell differentiation GO:0002318 9.37 BRAF KIT
15 response to inactivity GO:0014854 9.26 CAT DRD2
16 melanin biosynthetic process from tyrosine GO:0006583 9.16 DCT TYR
17 melanin biosynthetic process GO:0042438 9.13 DCT TYR TYRP1
18 pigmentation GO:0043473 9.02 DCT DRD2 KIT TYR TYRP1

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.8 BRAF CAT DCT KIT S100B TYR
2 oxidoreductase activity GO:0016491 9.46 CAT DCT TYR TYRP1
3 protein heterodimerization activity GO:0046982 9.26 BRAF DRD2 TYR TYRP1
4 protein homodimerization activity GO:0042803 9.1 CAT DRD2 KIT S100B TYR TYRP1

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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