MCID: AML001
MIFTS: 41

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15
Melanoma, Amelanotic 44 73
Amelanotic Skin Melanoma 73
Melanoma Amelanotic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 44 D018328
NCIt 50 C3802
SNOMED-CT 68 70594002
UMLS 73 C0206735

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to gastrointestinal stromal tumor and skin amelanotic melanoma. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Detoxification of Reactive Oxygen Species. Affiliated tissues include skin, brain and lung, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be pink,... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal stromal tumor 29.6 BRAF KIT S100B
2 skin amelanotic melanoma 12.1
3 melanoma 11.0
4 malignant spindle cell melanoma 10.5 KIT TYR
5 breast angiosarcoma 10.5 KIT TYR
6 reticular perineurioma 10.5 KIT S100B
7 vulvar melanoma 10.5 KIT TYR
8 mixed type thymoma 10.5 KIT S100B
9 aggressive digital papillary adenocarcinoma 10.5 KIT S100B
10 malignant skin fibrous histiocytoma 10.5 KIT TYR
11 myopericytoma 10.4 BRAF S100B
12 malignant dermis tumor 10.4 KIT TYR
13 syringocystadenoma papilliferum 10.4 BRAF S100B
14 perineurioma 10.4 KIT S100B
15 embryonal sarcoma 10.4 KIT S100B
16 central nervous system melanocytic neoplasm 10.4 KIT TYR
17 polymorphous low-grade adenocarcinoma 10.4 KIT S100B
18 juvenile xanthogranuloma 10.4 BRAF S100B
19 angiomyolipoma 10.4 KIT TYR
20 acral lentiginous melanoma 10.4 BRAF KIT
21 mucosal melanoma 10.3 BRAF KIT
22 hermansky-pudlak syndrome 3 10.3 TYR TYRP1
23 valproate embryopathy 10.3 CAT PARP1
24 albinism 10.2
25 dyschromatosis symmetrica hereditaria 10.2 TYR TYRP1
26 neurilemmoma 10.2 KIT S100B
27 integumentary system cancer 10.2 KIT TYR
28 ocular albinism 10.2 TYR TYRP1
29 ganglioglioma 10.2 BRAF S100B
30 neurofibroma 10.2 KIT S100B
31 oculocutaneous albinism 10.2
32 clear cell sarcoma 10.1 KIT S100B
33 melanoma, uveal 10.1 BRAF S100B TYR
34 bladder transitional cell papilloma 10.1 CYCS PARP1
35 choroiditis 10.0
36 adenocarcinoma 10.0
37 pyogenic granuloma 10.0
38 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0 CAT TYR TYRP1
39 skin melanoma 10.0 BRAF KIT TYR
40 hemorrhagic cystitis 10.0 CYCS PARP1
41 dowling-degos disease 1 10.0 KIT TYR TYRP1
42 melanoma metastasis 10.0
43 endotheliitis 10.0
44 waardenburg's syndrome 10.0 KIT TYR TYRP1
45 langerhans cell histiocytosis 10.0 BRAF S100B
46 cutaneous mastocytosis 9.9 CTSG KIT
47 mast cell neoplasm 9.8 CTSG KIT
48 vogt-koyanagi-harada disease 9.8 TYR TYRP1
49 ovarian cancer 9.8
50 melanosis, neurocutaneous 9.8

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 TYRP1 TYR CYCS KIT PARP1 BRAF
2 cellular MP:0005384 10 TYRP1 TYR CYCS KIT PARP1 BRAF
3 homeostasis/metabolism MP:0005376 9.91 TYRP1 TYR KIT PARP1 BRAF S100B
4 mortality/aging MP:0010768 9.86 CTSG CYCS KIT TYRP1 BRAF PARP1
5 craniofacial MP:0005382 9.83 TYR CYCS KIT TYRP1 BRAF
6 hearing/vestibular/ear MP:0005377 9.8 KIT TYRP1 BRAF PARP1 TYR
7 integument MP:0010771 9.8 KIT TYRP1 BRAF PARP1 S100B TYR
8 neoplasm MP:0002006 9.63 KIT TYRP1 BRAF CAT TYR CTSG
9 pigmentation MP:0001186 9.26 TYR KIT TYRP1 BRAF
10 vision/eye MP:0005391 9.02 TYRP1 TYR KIT PARP1 BRAF

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

41
Skin, Brain, Lung, Colon, Testes, Endothelial, Breast

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 258)
# Title Authors Year
1
Unsuspected Amelanotic Melanoma in an Elephantiasis Foot. ( 29854646 )
2018
2
Amelanotic melanoma: a unique case study and review of the literature. ( 29602781 )
2018
3
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. ( 28976625 )
2018
4
Amelanotic melanoma. ( 29545447 )
2018
5
Subungual Amelanotic Melanoma Masquerading as Onychomycosis. ( 29755903 )
2018
6
Noninvasive Gene Expression Testing in Amelanotic Melanoma. ( 29238803 )
2018
7
Unexpected amelanotic melanoma simulators. ( 28106946 )
2017
8
Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study. ( 28555837 )
2017
9
Congenital amelanotic melanoma in a crossbred heifer calf. ( 28423984 )
2017
10
Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution. ( 29166513 )
2017
11
Proteasome inhibitors against amelanotic melanoma. ( 28281027 )
2017
12
An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings. ( 29141067 )
2017
13
Amelanotic Melanoma Arising in Filarial Leg: A Report of a Rare Case. ( 28273977 )
2017
14
Amelanotic melanoma in a child, the importance of suspecting the disease. ( 28636079 )
2017
15
A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report. ( 28171845 )
2017
16
Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. ( 28623530 )
2017
17
Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. ( 28746718 )
2017
18
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. ( 27206673 )
2016
19
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. ( 26949998 )
2016
20
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma. ( 27064601 )
2016
21
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
22
Presentation of a patient with in situ amelanotic melanoma of the vulva. ( 29894090 )
2016
23
Amelanotic melanoma in the bone marrow. ( 28092878 )
2016
24
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis. ( 27206672 )
2016
25
Amelanotic melanoma in albinism: the power of dermatoscopy. ( 26290313 )
2015
26
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader. ( 26348327 )
2015
27
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation. ( 26266008 )
2015
28
Intracranial amelanotic melanoma: a case report with literature review. ( 25963017 )
2015
29
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. ( 26204672 )
2015
30
BILATERALLY SYMMETRICAL ORAL AMELANOTIC MELANOMA IN A BOA CONSTRICTOR (BOA CONSTRICTOR CONSTRICTOR). ( 26352976 )
2015
31
Metastatic amelanotic melanoma with occult primary masquerading as sarcoma. ( 25859510 )
2015
32
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. ( 25500029 )
2015
33
Polarized light dermoscopy to aid in the diagnosis of new pink lesions in an amelanotic melanoma survivor. ( 26568348 )
2015
34
Amelanotic melanoma mimicking an atypical fibrohistiocytic lesion. ( 25993406 )
2015
35
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento. ( 26498081 )
2015
36
Primary central nervous system amelanotic melanoma in a Hispanic male: Case report. ( 25031666 )
2014
37
Amelanotic melanoma mimicking cutaneous epitheliomas. ( 24629365 )
2014
38
Amelanotic melanoma masquerading as a pyogenic granuloma: caution warranted. ( 24914083 )
2014
39
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. ( 24393566 )
2014
40
Oral amelanotic melanoma of the maxilla. ( 25628704 )
2014
41
Amelanotic melanoma masquerading as a superficial small round cell tumor: a diagnostic challenge. ( 25484414 )
2014
42
Amelanotic melanoma: a case with chr 9 monosomy. ( 24965431 )
2014
43
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. ( 24915302 )
2014
44
Primary amelanotic melanoma of the nasal cavity: a case report. ( 24452896 )
2014
45
Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges. ( 23591855 )
2013
46
BRAF and KIT somatic mutations are present in amelanotic melanoma. ( 23938765 )
2013
47
Amelanotic melanoma mimicking keratoacanthoma: the diagnostic role of dermoscopy. ( 23113565 )
2013
48
Reflectance confocal microscopy in the diagnosis of partially and completely amelanotic melanoma: report on seven cases. ( 22324783 )
2013
49
Diagnostic usefulness of findings in Doppler sonography for amelanotic melanoma. ( 23802993 )
2013
50
Hyporeflective pagetoid cells: A new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. ( 24329036 )
2013

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.26 BRAF CAT CTSG TYR
2 melanosome membrane GO:0033162 8.62 TYR TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.73 CAT CYCS TYR TYRP1
2 response to UV GO:0009411 9.52 CAT TYR
3 response to cAMP GO:0051591 9.51 BRAF TYR
4 long-term synaptic potentiation GO:0060291 9.49 BRAF S100B
5 visual learning GO:0008542 9.48 BRAF KIT
6 thymus development GO:0048538 9.46 BRAF TYR
7 response to radiation GO:0009314 9.4 CAT KIT
8 response to cadmium ion GO:0046686 9.37 CAT KIT
9 cellular response to oxidative stress GO:0034599 9.33 CAT CYCS PARP1
10 melanocyte differentiation GO:0030318 9.32 KIT TYRP1
11 melanin biosynthetic process GO:0042438 9.26 TYR TYRP1
12 myeloid progenitor cell differentiation GO:0002318 8.96 BRAF KIT
13 pigmentation GO:0043473 8.8 KIT TYR TYRP1

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.35 CAT KIT S100B TYR TYRP1
2 metal ion binding GO:0046872 9.23 BRAF CAT CYCS KIT PARP1 S100B
3 monooxygenase activity GO:0004497 9.16 TYR TYRP1

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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