MCID: AML001
MIFTS: 39

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 43 71
Amelanotic Skin Melanoma 71
Melanoma Amelanotic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 43 D018328
NCIt 49 C3802
SNOMED-CT 67 70594002
UMLS 71 C0206735 C0349515

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to malignant skin fibrous histiocytoma and acral lentiginous melanoma. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Senescence and Autophagy in Cancer. Affiliated tissues include skin, lymph node and lung, and related phenotypes are cellular and integument

Wikipedia : 74 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 malignant skin fibrous histiocytoma 30.9 MLANA KIT
2 acral lentiginous melanoma 30.8 MLANA KIT BRAF
3 albinism 30.7 TYRP1 TYR MITF
4 vulvar melanoma 30.6 MLANA KIT
5 mucosal melanoma 30.5 MITF KIT BRAF
6 skin melanoma 30.4 TYR MLANA MITF KIT BRAF
7 oculocutaneous albinism 30.3 TYRP1 TYR MITF DCT
8 albinism, oculocutaneous, type ia 30.3 TYRP1 TYR
9 melanoma 30.2 TYRP1 TYR S100B MLANA MITF KIT
10 lentigo maligna melanoma 30.2 S100B MLANA MITF
11 nodular malignant melanoma 30.1 TYR MLANA MITF KIT BRAF
12 lentigines 30.1 TYR MLANA MITF KIT BRAF
13 skin carcinoma 29.9 TYRP1 TYR THBS1 MLANA
14 leiomyosarcoma 29.9 SERPINA3 S100B MLANA KIT
15 vitiligo-associated multiple autoimmune disease susceptibility 1 29.7 TYRP1 TYR MLANA MITF DCT CAT
16 sarcoma 29.6 SERPINA3 S100B KIT CYCS BRAF
17 colon adenocarcinoma 29.6 PARP1 CYCS BRAF ANXA5
18 gastrointestinal stromal tumor 29.6 S100B KIT BRAF ANXA5
19 neurilemmoma 29.4 TYR SERPINA3 S100B MLANA MITF KIT
20 microphthalmia 29.2 TYRP1 TYR S100B MLANA MITF KIT
21 neuroblastoma 29.0 TYR PARP1 KIT CYCS CAT ANXA5
22 melanoma, uveal 27.9 TYR THBS1 S100B MLANA MITF KIT
23 skin amelanotic melanoma 12.5
24 melanoma, cutaneous malignant 10 11.1
25 ciliary body cancer 10.5 TYR MLANA
26 halo nevi 10.5 TYR MLANA
27 melanoacanthoma 10.5 TYR MLANA
28 sarcomatoid transitional cell carcinoma 10.5 TYR MLANA
29 diffuse meningeal melanocytosis 10.5 TYR MLANA
30 reticular perineurioma 10.5 S100B KIT
31 meningeal melanocytoma 10.5 S100B MLANA
32 myopericytoma 10.5 S100B BRAF
33 malignant anus melanoma 10.5 MLANA KIT
34 malignant dermis tumor 10.5 MLANA KIT
35 spinal cord melanoma 10.5 TYR MLANA
36 benign perivascular tumor 10.4 MLANA KIT
37 malignant triton tumor 10.4 S100B MLANA
38 small intestine leiomyoma 10.4 MLANA KIT
39 hepatic angiomyolipoma 10.4 MLANA KIT
40 thymus clear cell carcinoma 10.4 MLANA KIT
41 retroperitoneal sarcoma 10.4 MLANA KIT
42 epithelioid malignant peripheral nerve sheath tumor 10.4 S100B MLANA
43 mucinous stomach adenocarcinoma 10.3 MLANA KIT
44 basal cell carcinoma 10.3
45 pyogenic granuloma 10.3
46 carbuncle 10.3 CYCS CAT
47 albinism, oculocutaneous, type v 10.3 TYRP1 TYR
48 cutaneous solitary mastocytoma 10.3 SERPINA3 KIT
49 type c thymoma 10.3 SERPINA3 KIT
50 albinism, oculocutaneous, type iv 10.3 TYRP1 TYR DCT

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 BRAF CAT CYCS DRD2 KIT LAMP1
2 integument MP:0010771 10.25 BRAF DCT DRD2 KIT LAMP1 MITF
3 homeostasis/metabolism MP:0005376 10.23 BRAF CAT DCT DRD2 KIT MITF
4 craniofacial MP:0005382 10.04 BRAF CYCS KIT LAMP1 MITF TYR
5 neoplasm MP:0002006 9.97 BRAF CAT CTSG DRD2 KIT THBS1
6 normal MP:0002873 9.97 ANXA5 BRAF CTSG DRD2 KIT LAMP1
7 hearing/vestibular/ear MP:0005377 9.95 BRAF KIT MITF PARP1 TYR TYRP1
8 limbs/digits/tail MP:0005371 9.95 ANXA5 BRAF DRD2 KIT MITF THBS1
9 pigmentation MP:0001186 9.86 BRAF DCT DRD2 KIT MITF MLANA
10 renal/urinary system MP:0005367 9.7 BRAF DRD2 KIT MITF PARP1 THBS1
11 skeleton MP:0005390 9.65 ANXA5 BRAF CYCS DRD2 KIT LAMP1
12 vision/eye MP:0005391 9.23 BRAF DCT KIT MITF PARP1 THBS1

Drugs & Therapeutics for Amelanotic Melanoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cisplatin
CISPLATIN PWDR

Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

40
Skin, Lymph Node, Lung, Testes, Endothelial, Brain, Colon

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 841)
# Title Authors PMID Year
1
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. 54 61
19133143 2009
2
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: effects of altering intracellular pH and pink-eyed dilution gene expression. 54 61
16199032 2006
3
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. 54 61
16584089 2006
4
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. 54 61
16087843 2005
5
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. 61 54
14634018 2004
6
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport. 61 54
12190873 2002
7
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. 61 54
11812790 2002
8
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. 54 61
11775059 2001
9
Translation rate of human tyrosinase determines its N-linked glycosylation level. 54 61
11069924 2001
10
Sensitivity of transplantable melanoma cells to cytokines with regard to their spontaneous apoptosis. 54 61
12107342 2001
11
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. 61 54
10890385 2000
12
Inhibition of melanin synthesis by cystamine in human melanoma cells. 54 61
10620110 2000
13
Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V. 61 54
10763124 2000
14
Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. 61 54
10381529 1999
15
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. 61 54
9877098 1998
16
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. 61 54
9177196 1997
17
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. 54 61
7535606 1994
18
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs. 61 54
7886004 1994
19
Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. 54 61
8008452 1994
20
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy. 54 61
8110729 1994
21
Malignant melanoma of the nasal cavity. 61 54
7779028 1994
22
Amelanotic melanoma of the oral cavity. 54 61
8410206 1993
23
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma. 61 54
8433011 1993
24
Tyrosinase gene transcription and its control by melanogenic inhibitors. 54 61
8433001 1993
25
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells. 61 54
1903481 1991
26
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. 54 61
1782361 1991
27
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. 54 61
2200526 1990
28
The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. 61
32437906 2020
29
Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. 61
31432325 2020
30
Protein-Bound Polysaccharides from Coriolus Versicolor Induce RIPK1/RIPK3/MLKL-Mediated Necroptosis in ER-Positive Breast Cancer and Amelanotic Melanoma Cells. 61
32531147 2020
31
The heel amelanotic melanoma, a rare subtype of skin cancer misdiagnosed as foot ulcer: A case report. 61
32160649 2020
32
Amelanotic melanoma recurrence diagnosed by fine-needle aspiration cytology: A case report. 61
32558348 2020
33
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA. 61
30908472 2020
34
Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck. 61
32449432 2020
35
Pathology features and the results of treatment of two cases of posterior choroidal leiomyoma. 61
32448235 2020
36
Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma. 61
31568773 2020
37
Primary amelanotic melanoma of the mandibular gingiva. 61
32380816 2020
38
Amelanotic Melanoma Concealed by Psoriasis. 61
31930427 2020
39
Sinonasal amelanotic melanoma with neuroendocrine differentiation: a diagnostic conundrum. 61
32164472 2020
40
Coexistence of amelanotic melanoma and capillary malformation on the same sole: An unusual case with dermatoscopic findings. 61
32227568 2020
41
Amelanotic melanoma of the nail apparatus with regression previously diagnosed as melanoma of unknown primary site with a lymph node metastasis: A case report. 61
31762069 2020
42
Choroidal amelanotic tumours: clinical differentiation of benign from malignant lesions in 5586 cases. 61
31023712 2020
43
Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells. 61
31515931 2020
44
Primary amelanotic melanoma of the male urethra: A rare entity and diagnostic challenge. 61
32274353 2020
45
A rare case of acral amelanotic melanoma, nodular type. 61
31531925 2019
46
Circumscribed choroidal hemangioma: An overview of clinical manifestation, diagnosis and management. 61
31755430 2019
47
Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method. 61
30985194 2019
48
Dermoscopy of primary cutaneous B- and T-cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case-control study with histopathologic correlation. 61
31347153 2019
49
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. 61
31172223 2019
50
Rare presentation of eczema-like amelanotic melanoma of the forearm with its dermoscopic differentiation. 61
31839783 2019

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 TYRP1 TYR MITF KIT DCT BRAF
2 11.52 THBS1 LAMP1 BRAF
3
Show member pathways
11.31 TYRP1 TYR DCT
4 9.76 PARP1 CYCS
5 9.5 TYRP1 TYR DCT

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 9.13 TYRP1 TYR DCT
2 melanosome GO:0042470 9.02 TYRP1 TYR MLANA LAMP1 DCT

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 THBS1 MITF CAT BRAF ANXA5
2 cellular response to oxidative stress GO:0034599 9.65 PARP1 CYCS CAT
3 visual learning GO:0008542 9.54 KIT DRD2 BRAF
4 developmental pigmentation GO:0048066 9.43 KIT DCT
5 myeloid progenitor cell differentiation GO:0002318 9.4 KIT BRAF
6 melanocyte differentiation GO:0030318 9.33 TYRP1 MITF KIT
7 response to inactivity GO:0014854 9.32 DRD2 CAT
8 melanin biosynthetic process from tyrosine GO:0006583 9.26 TYR DCT
9 melanin biosynthetic process GO:0042438 9.13 TYRP1 TYR DCT
10 pigmentation GO:0043473 9.1 TYRP1 TYR MITF KIT DRD2 DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 TYRP1 TYR THBS1 S100B PARP1 DRD2
2 monophenol monooxygenase activity GO:0004503 8.62 TYRP1 TYR

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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