MCID: AML001
MIFTS: 42

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 45 74
Amelanotic Skin Melanoma 74
Melanoma Amelanotic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 45 D018328
NCIt 51 C3802
SNOMED-CT 69 70594002

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to acral lentiginous melanoma and vitiligo-associated multiple autoimmune disease susceptibility 1. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Tyrosine metabolism and Granzyme Pathway. Affiliated tissues include skin, lung and brain, and related phenotypes are behavior/neurological and cellular

Wikipedia : 77 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 acral lentiginous melanoma 30.1 BRAF KIT
2 vitiligo-associated multiple autoimmune disease susceptibility 1 29.9 TYR TYRP1
3 gastrointestinal stromal tumor 29.8 BRAF KIT S100B
4 skin amelanotic melanoma 12.3
5 melanoma 11.2
6 albinism 10.4
7 malignant spindle cell melanoma 10.3 KIT TYR
8 breast angiosarcoma 10.3 KIT TYR
9 reticular perineurioma 10.3 KIT S100B
10 perineurioma 10.3 KIT S100B
11 oculocutaneous albinism 10.3
12 mixed type thymoma 10.3 KIT S100B
13 aggressive digital papillary adenocarcinoma 10.3 KIT S100B
14 vulvar melanoma 10.3 KIT TYR
15 malignant skin fibrous histiocytoma 10.3 KIT TYR
16 malignant dermis tumor 10.3 KIT TYR
17 lentigo maligna melanoma 10.2
18 gonadoblastoma 10.2 CAT KIT
19 polymorphous low-grade adenocarcinoma 10.2 KIT S100B
20 central nervous system melanocytic neoplasm 10.2 KIT TYR
21 angiomyolipoma 10.2 KIT TYR
22 adenocarcinoma 10.2
23 pyogenic granuloma 10.2
24 valproate embryopathy 10.2 CAT PARP1
25 cutaneous fibrous histiocytoma 10.2 S100B SERPINA3
26 odontogenic myxoma 10.2 S100B SERPINA3
27 cutaneous solitary mastocytoma 10.2 KIT SERPINA3
28 granular cell tumor 10.2 S100B SERPINA3
29 myopericytoma 10.2 BRAF S100B
30 bladder transitional cell papilloma 10.1 CYCS PARP1
31 juvenile xanthogranuloma 10.1 BRAF S100B
32 malignant fibroxanthoma 10.1 S100B SERPINA3
33 hemorrhagic cystitis 10.1 CYCS PARP1
34 fibrosarcoma of bone 10.1 KIT SERPINA3
35 melanoma metastasis 10.1
36 malignant conjunctival melanoma 10.1
37 neurilemmoma 10.1 KIT S100B
38 mucosal melanoma 10.1 BRAF KIT
39 neurofibroma 10.1 KIT S100B
40 piebald trait 10.1 KIT TYR
41 albinism, oculocutaneous, type ii 10.1 TYR TYRP1
42 albinism, oculocutaneous, type iii 10.1 TYR TYRP1
43 albinism, oculocutaneous, type ib 10.0 TYR TYRP1
44 albinism, oculocutaneous, type v 10.0 TYR TYRP1
45 erdheim-chester disease 10.0 BRAF SERPINA3
46 albinism, oculocutaneous, type vii 10.0 TYR TYRP1
47 albinism, oculocutaneous, type ia 10.0 TYR TYRP1
48 connective tissue cancer 10.0 KIT SERPINA3
49 ganglioglioma 10.0 BRAF S100B
50 embryonal sarcoma 10.0 KIT S100B SERPINA3

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 BRAF CYCS KIT PARP1 S100B TYR
2 cellular MP:0005384 9.98 BRAF CAT CYCS KIT PARP1 TYR
3 integument MP:0010771 9.87 BRAF DCT KIT PARP1 S100B TYR
4 craniofacial MP:0005382 9.8 BRAF CYCS KIT TYR TYRP1
5 hearing/vestibular/ear MP:0005377 9.77 BRAF KIT PARP1 TYR TYRP1
6 nervous system MP:0003631 9.7 BRAF CYCS DCT KIT PARP1 TYR
7 neoplasm MP:0002006 9.65 BRAF CAT KIT TYR TYRP1
8 pigmentation MP:0001186 9.35 BRAF DCT KIT TYR TYRP1
9 vision/eye MP:0005391 9.1 BRAF DCT KIT PARP1 TYR TYRP1

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

42
Skin, Lung, Brain, Colon, Bone, Testes, Breast

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 268)
# Title Authors Year
1
Amelanotic melanoma. ( 30672881 )
2019
2
Multiple bone metastases from an amelanotic melanoma of unknown primary origin. ( 30848028 )
2019
3
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA. ( 30908472 )
2019
4
Unsuspected Amelanotic Melanoma in an Elephantiasis Foot. ( 29854646 )
2018
5
Amelanotic melanoma: a unique case study and review of the literature. ( 29602781 )
2018
6
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. ( 28976625 )
2018
7
Amelanotic melanoma. ( 29545447 )
2018
8
Subungual Amelanotic Melanoma Masquerading as Onychomycosis. ( 29755903 )
2018
9
Noninvasive Gene Expression Testing in Amelanotic Melanoma. ( 29238803 )
2018
10
Multiple cutaneous metastases of amelanotic melanoma. ( 30050605 )
2018
11
Amelanotic melanoma arising in an area of SLURP-1 mutated Mal de Meleda. ( 30246339 )
2018
12
Melanization of Bomirski hamster amelanotic melanoma cells (Ab line) depends on the type of culture medium. ( 30370913 )
2018
13
Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma. ( 30474018 )
2018
14
Reflectance confocal microscopy margin mapping and monitoring of an amelanotic melanoma in situ of the ear. ( 30592021 )
2018
15
Polypoid amelanotic melanoma: a diagnostic challenge. ( 30677854 )
2018
16
Unexpected amelanotic melanoma simulators. ( 28106946 )
2017
17
Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study. ( 28555837 )
2017
18
Congenital amelanotic melanoma in a crossbred heifer calf. ( 28423984 )
2017
19
Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution. ( 29166513 )
2017
20
Proteasome inhibitors against amelanotic melanoma. ( 28281027 )
2017
21
An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings. ( 29141067 )
2017
22
Amelanotic Melanoma Arising in Filarial Leg: A Report of a Rare Case. ( 28273977 )
2017
23
Amelanotic melanoma in a child, the importance of suspecting the disease. ( 28636079 )
2017
24
A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report. ( 28171845 )
2017
25
Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. ( 28623530 )
2017
26
Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. ( 28746718 )
2017
27
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. ( 27206673 )
2016
28
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. ( 26949998 )
2016
29
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma. ( 27064601 )
2016
30
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
31
Presentation of a patient with in situ amelanotic melanoma of the vulva. ( 29894090 )
2016
32
Amelanotic melanoma in the bone marrow. ( 28092878 )
2016
33
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis. ( 27206672 )
2016
34
Amelanotic melanoma in albinism: the power of dermatoscopy. ( 26290313 )
2015
35
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader. ( 26348327 )
2015
36
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation. ( 26266008 )
2015
37
Intracranial amelanotic melanoma: a case report with literature review. ( 25963017 )
2015
38
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. ( 26204672 )
2015
39
BILATERALLY SYMMETRICAL ORAL AMELANOTIC MELANOMA IN A BOA CONSTRICTOR (BOA CONSTRICTOR CONSTRICTOR). ( 26352976 )
2015
40
Metastatic amelanotic melanoma with occult primary masquerading as sarcoma. ( 25859510 )
2015
41
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. ( 25500029 )
2015
42
Polarized light dermoscopy to aid in the diagnosis of new pink lesions in an amelanotic melanoma survivor. ( 26568348 )
2015
43
Amelanotic melanoma mimicking an atypical fibrohistiocytic lesion. ( 25993406 )
2015
44
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento. ( 26498081 )
2015
45
Primary central nervous system amelanotic melanoma in a Hispanic male: Case report. ( 25031666 )
2014
46
Amelanotic melanoma mimicking cutaneous epitheliomas. ( 24629365 )
2014
47
Amelanotic melanoma masquerading as a pyogenic granuloma: caution warranted. ( 24914083 )
2014
48
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. ( 24393566 )
2014
49
Oral amelanotic melanoma of the maxilla. ( 25628704 )
2014
50
Amelanotic melanoma masquerading as a superficial small round cell tumor: a diagnostic challenge. ( 25484414 )
2014

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.21 DCT TYR TYRP1
2
Show member pathways
11.01 CYCS PARP1
3 10.62 CYCS PARP1
4 9.56 CYCS PARP1
5 9.5 DCT TYR TYRP1

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 9.13 DCT TYR TYRP1
2 melanosome membrane GO:0033162 8.8 DCT TYR TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.72 CAT CYCS DCT TYR TYRP1
2 somatic stem cell population maintenance GO:0035019 9.56 BRAF KIT
3 response to cAMP GO:0051591 9.55 BRAF TYR
4 response to UV GO:0009411 9.54 CAT TYR
5 cellular response to oxidative stress GO:0034599 9.54 CAT CYCS PARP1
6 visual learning GO:0008542 9.52 BRAF KIT
7 long-term synaptic potentiation GO:0060291 9.51 BRAF S100B
8 thymus development GO:0048538 9.49 BRAF TYR
9 response to radiation GO:0009314 9.48 CAT KIT
10 response to cadmium ion GO:0046686 9.46 CAT KIT
11 melanocyte differentiation GO:0030318 9.43 KIT TYRP1
12 developmental pigmentation GO:0048066 9.4 DCT KIT
13 myeloid progenitor cell differentiation GO:0002318 9.26 BRAF KIT
14 melanin biosynthetic process from tyrosine GO:0006583 9.16 DCT TYR
15 melanin biosynthetic process GO:0042438 9.13 DCT TYR TYRP1
16 pigmentation GO:0043473 8.92 DCT KIT TYR TYRP1

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.46 CAT DCT TYR TYRP1
2 protein homodimerization activity GO:0042803 9.35 CAT KIT S100B TYR TYRP1
3 metal ion binding GO:0046872 9.28 BRAF CAT CYCS DCT KIT PARP1

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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