MCID: AML001
MIFTS: 39

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 43 71
Amelanotic Skin Melanoma 71
Melanoma Amelanotic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 43 D018328
NCIt 49 C3802
SNOMED-CT 67 70594002
UMLS 71 C0206735 C0349515

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to malignant skin fibrous histiocytoma and albinism. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Tyrosine metabolism. Affiliated tissues include skin, lung and endothelial, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 malignant skin fibrous histiocytoma 30.9 MLANA KIT
2 albinism 30.6 TYRP1 TYR MITF
3 skin melanoma 30.6 TYR MLANA MITF BRAF
4 acral lentiginous melanoma 30.6 VIM KIT BRAF
5 malignant choroid melanoma 30.6 MLANA MITF
6 eccrine porocarcinoma 30.4 VIM S100B
7 mucosal melanoma 30.3 MITF KIT BRAF
8 albinism, oculocutaneous, type ia 30.3 TYRP1 TYR
9 oculocutaneous albinism 30.2 TYRP1 TYR MITF DCT
10 lentigo maligna melanoma 30.2 S100B MLANA MITF
11 nodular malignant melanoma 30.1 TYR MLANA MITF KIT BRAF
12 spindle cell sarcoma 30.1 VIM SERPINA3 S100B
13 melanoma 30.1 TYRP1 TYR S100B MLANA MITF KIT
14 constipation 30.0 VIM S100B KIT CAT
15 giant cell tumor 29.8 VIM SERPINA3 S100B
16 optic nerve disease 29.8 TYR SERPINA3 CYCS
17 sarcoma 29.7 VIM S100B KIT CYCS BRAF
18 rhabdomyosarcoma 29.6 VIM S100B KIT CYCS
19 vitiligo-associated multiple autoimmune disease susceptibility 1 29.6 TYRP1 TYR MLANA MITF DCT CAT
20 leiomyosarcoma 29.3 VIM SERPINA3 S100B MLANA KIT
21 histiocytoma 29.3 VIM SERPINA3 MITF KIT
22 gastrointestinal stromal tumor 29.0 VIM S100B KIT BRAF ANXA5
23 neurilemmoma 29.0 VIM TYR SERPINA3 S100B MITF KIT
24 microphthalmia 28.9 TYRP1 TYR S100B MLANA MITF KIT
25 neuroblastoma 28.7 TYR PARP1 KIT CYCS CAT ANXA5
26 melanoma, uveal 28.5 TYR S100B MLANA MITF KIT DCT
27 skin amelanotic melanoma 12.5
28 malignant ciliary body melanoma 10.5 TYR MLANA
29 ciliary body cancer 10.5 TYR MLANA
30 halo nevi 10.5 TYR MLANA
31 melanoacanthoma 10.5 TYR MLANA
32 diffuse meningeal melanocytosis 10.5 TYR MLANA
33 sarcomatoid transitional cell carcinoma 10.5 TYR MLANA
34 reticular perineurioma 10.5 S100B KIT
35 meningeal melanocytoma 10.5 S100B MLANA
36 vagina leiomyosarcoma 10.5 MLANA KIT
37 myopericytoma 10.5 S100B BRAF
38 selection of therapeutic option in melanoma 10.5 KIT BRAF
39 spinal cord melanoma 10.5 TYR MLANA
40 malignant anus melanoma 10.5 MLANA KIT
41 small intestine leiomyoma 10.5 MLANA KIT
42 jejunal neoplasm 10.5 MLANA KIT
43 malignant dermis tumor 10.5 MLANA KIT
44 vulvar melanoma 10.4 MLANA KIT
45 epithelioid malignant peripheral nerve sheath tumor 10.4 S100B MLANA
46 retroperitoneal sarcoma 10.4 MLANA KIT
47 hydromyelia 10.4 VIM S100B
48 bednar tumor 10.4 VIM S100B
49 primary hepatic neuroendocrine carcinoma 10.4 VIM S100B
50 thymus clear cell carcinoma 10.4 MLANA KIT

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 BRAF CAT CYCS DRD2 KIT LAMP1
2 hematopoietic system MP:0005397 10.18 ANXA5 BRAF CTSG CYCS DRD2 KIT
3 mortality/aging MP:0010768 10.18 BRAF CAT CTSG CYCS DRD2 KIT
4 integument MP:0010771 10.17 BRAF DCT DRD2 KIT LAMP1 MITF
5 immune system MP:0005387 10.16 ANXA5 BRAF CTSG CYCS DRD2 KIT
6 nervous system MP:0003631 10.06 BRAF CYCS DCT DRD2 KIT LAMP1
7 craniofacial MP:0005382 10.05 BRAF CYCS KIT LAMP1 MITF TYR
8 hearing/vestibular/ear MP:0005377 9.97 BRAF KIT MITF PARP1 TYR TYRP1
9 neoplasm MP:0002006 9.91 BRAF CAT CTSG DRD2 KIT TYR
10 normal MP:0002873 9.91 ANXA5 BRAF CTSG DRD2 KIT LAMP1
11 pigmentation MP:0001186 9.76 BRAF DCT DRD2 KIT MITF MLANA
12 skeleton MP:0005390 9.61 ANXA5 BRAF CYCS DRD2 KIT LAMP1
13 vision/eye MP:0005391 9.23 BRAF DCT KIT MITF PARP1 TYR

Drugs & Therapeutics for Amelanotic Melanoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cisplatin
CISPLATIN PWDR

Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

40
Skin, Lung, Endothelial, Lymph Node, Brain, Colon, Testes

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 831)
# Title Authors PMID Year
1
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. 54 61
19133143 2009
2
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: effects of altering intracellular pH and pink-eyed dilution gene expression. 54 61
16199032 2006
3
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. 54 61
16584089 2006
4
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. 54 61
16087843 2005
5
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. 54 61
14634018 2004
6
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport. 54 61
12190873 2002
7
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. 54 61
11812790 2002
8
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. 54 61
11775059 2001
9
Translation rate of human tyrosinase determines its N-linked glycosylation level. 54 61
11069924 2001
10
Sensitivity of transplantable melanoma cells to cytokines with regard to their spontaneous apoptosis. 54 61
12107342 2001
11
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. 54 61
10890385 2000
12
Inhibition of melanin synthesis by cystamine in human melanoma cells. 54 61
10620110 2000
13
Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V. 54 61
10763124 2000
14
Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. 54 61
10381529 1999
15
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. 54 61
9877098 1998
16
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. 54 61
9177196 1997
17
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. 54 61
7535606 1994
18
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs. 54 61
7886004 1994
19
Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. 54 61
8008452 1994
20
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy. 54 61
8110729 1994
21
Malignant melanoma of the nasal cavity. 54 61
7779028 1994
22
Amelanotic melanoma of the oral cavity. 54 61
8410206 1993
23
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma. 54 61
8433011 1993
24
Tyrosinase gene transcription and its control by melanogenic inhibitors. 54 61
8433001 1993
25
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells. 54 61
1903481 1991
26
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. 54 61
1782361 1991
27
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. 54 61
2200526 1990
28
Choroidal amelanotic tumours: clinical differentiation of benign from malignant lesions in 5586 cases. 61
31023712 2020
29
Amelanotic melanoma of the nail apparatus with regression previously diagnosed as melanoma of unknown primary site with a lymph node metastasis: A case report. 61
31762069 2020
30
Amelanotic Melanoma Concealed by Psoriasis. 61
31930427 2020
31
Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells. 61
31515931 2020
32
Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method. 61
30985194 2019
33
A rare case of acral amelanotic melanoma, nodular type. 61
31531925 2019
34
Circumscribed choroidal hemangioma: An overview of clinical manifestation, diagnosis and management. 61
31755430 2019
35
Dermoscopy of primary cutaneous B- and T-cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case-control study with histopathologic correlation. 61
31347153 2019
36
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. 61
31172223 2019
37
Primary vaginal malignant melanoma: A rare entity with review of literature. 61
31898678 2019
38
Rare presentation of eczema-like amelanotic melanoma of the forearm with its dermoscopic differentiation. 61
31839783 2019
39
A Sheep in Wolf's Clothing: Lobular Pyogenic Granuloma Masquerading Nodular Amelanotic Melanoma. 61
31850113 2019
40
Cutaneous granuloma mimicking amelanotic melanoma. 61
31578833 2019
41
Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma. 61
31568773 2019
42
A Painful Step - Pendulating Plantar Eccrine Poroma. 61
31850106 2019
43
Atypical fibroxanthoma mimicking amelanotic melanoma in dermoscopy. 61
31616227 2019
44
Amelanotic melanoma arising in an area of SLURP-1 mutated Mal de Meleda. 61
30246339 2019
45
Reflectance confocal microscopy margin mapping and monitoring of an amelanotic melanoma in situ of the ear. 61
30592021 2019
46
Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. 61
31432325 2019
47
Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia. 61
31687116 2019
48
Amelanotic melanoma. 61
30672881 2019
49
Recurrent amelanotic melanoma of nasal cavity: Biological variability and unpredictable behavior of mucosal melanoma. A case report. 61
31285816 2019
50
Fixed oil from seeds of narrow-leaved ash (F. angustifolia subsp. angustifolia): Chemical profile, antioxidant and antiproliferative activities. 61
30884667 2019

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 TYRP1 TYR MITF KIT DCT BRAF
2
Show member pathways
11.31 TYRP1 TYR DCT
3 9.76 PARP1 CYCS
4 9.5 TYRP1 TYR DCT

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 9.13 TYRP1 TYR DCT
2 melanosome GO:0042470 9.02 TYRP1 TYR MLANA LAMP1 DCT

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to oxidative stress GO:0034599 9.63 PARP1 CYCS CAT
2 visual learning GO:0008542 9.54 KIT DRD2 BRAF
3 developmental pigmentation GO:0048066 9.43 KIT DCT
4 myeloid progenitor cell differentiation GO:0002318 9.4 KIT BRAF
5 melanocyte differentiation GO:0030318 9.33 TYRP1 MITF KIT
6 response to inactivity GO:0014854 9.32 DRD2 CAT
7 melanin biosynthetic process from tyrosine GO:0006583 9.26 TYR DCT
8 melanin biosynthetic process GO:0042438 9.13 TYRP1 TYR DCT
9 pigmentation GO:0043473 9.1 TYRP1 TYR MITF KIT DRD2 DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.63 TYRP1 TYR S100B KIT DRD2 CAT
2 identical protein binding GO:0042802 9.23 VIM TYRP1 TYR S100B PARP1 DRD2
3 monophenol monooxygenase activity GO:0004503 8.96 TYRP1 TYR

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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