MCID: AML001
MIFTS: 37

Amelanotic Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 15 17
Melanoma, Amelanotic 44 71
Amelanotic Skin Melanoma 71
Melanoma Amelanotic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 44 D018328
NCIt 50 C3802
SNOMED-CT 67 70594002
UMLS 71 C0206735 C0349515

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to albinism and oculocutaneous albinism. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Phenylalanine metabolism. Affiliated tissues include skin, endothelial and lymph node, and related phenotypes are integument and neoplasm

Wikipedia : 74 Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. They can be... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 albinism 30.8 TYRP1 TYR DCT
2 oculocutaneous albinism 30.6 TYRP1 TYR DCT
3 malignant skin fibrous histiocytoma 30.6 MLANA KIT
4 nodular malignant melanoma 30.5 TYR MLANA KIT BRAF
5 acral lentiginous melanoma 30.5 VIM KIT BRAF
6 lentigo maligna melanoma 30.4 S100B MLANA
7 vitiligo-associated multiple autoimmune disease susceptibility 1 30.1 TYRP1 TYR MLANA DCT CAT
8 albinism, oculocutaneous, type ia 30.1 TYRP1 TYR
9 eccrine porocarcinoma 30.1 VIM S100B
10 constipation 29.9 VIM S100B KIT CAT
11 well-differentiated liposarcoma 29.9 SERPINA3 MLANA KIT
12 skin carcinoma 29.8 TYRP1 TYR MLANA KIT BRAF ANXA5
13 colon adenocarcinoma 29.8 PARP1 CYCS BRAF ANXA5
14 microphthalmia 29.8 TYRP1 TYR S100B MLANA KIT DCT
15 sarcoma 29.7 VIM S100B KIT CYCS BRAF
16 neurilemmoma 29.7 VIM TYR SERPINA3 S100B KIT
17 melanoma, uveal 29.6 TYR S100B MLANA KIT DCT BRAF
18 spindle cell sarcoma 29.6 VIM SERPINA3 S100B KIT
19 melanoma 29.6 VIM TYRP1 TYR S100B PARP1 MLANA
20 gastrointestinal stromal tumor 29.5 VIM S100B KIT BRAF ANXA5
21 skin melanoma 29.2 TYRP1 TYR SERPINA3 S100B MLANA KIT
22 skin amelanotic melanoma 11.3
23 malignant leptomeningeal tumor 10.4 TYR MLANA
24 meningeal melanoma 10.4 TYR MLANA
25 ciliary body cancer 10.4 TYR MLANA
26 melanoacanthoma 10.4 TYR MLANA
27 halo nevi 10.4 TYR MLANA
28 sarcomatoid transitional cell carcinoma 10.4 TYR MLANA
29 spinal cord melanoma 10.4 TYR MLANA
30 melanomatosis 10.4 TYR MLANA
31 reticular perineurioma 10.4 S100B KIT
32 diffuse meningeal melanocytosis 10.4 TYR MLANA
33 meningeal melanocytoma 10.4 S100B MLANA
34 myopericytoma 10.4 S100B BRAF
35 epithelioid cell melanoma 10.4 TYR MLANA
36 malignant anus melanoma 10.4 MLANA KIT
37 malignant dermis tumor 10.4 MLANA KIT
38 malignant triton tumor 10.4 S100B MLANA
39 benign perivascular tumor 10.4 MLANA KIT
40 vulvar melanoma 10.3 MLANA KIT
41 small intestine leiomyoma 10.3 MLANA KIT
42 skin sarcoma 10.3 MLANA KIT
43 mucinous stomach adenocarcinoma 10.3 MLANA KIT
44 retroperitoneal sarcoma 10.3 MLANA KIT
45 glomangiomatosis 10.3 MLANA KIT
46 hydromyelia 10.3 VIM S100B
47 mucosal melanoma 10.3
48 bednar tumor 10.3 VIM S100B
49 thymus clear cell carcinoma 10.3 MLANA KIT
50 primary hepatic neuroendocrine carcinoma 10.3 VIM S100B

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 10 BRAF DCT DRD2 KIT LAMP1 MLANA
2 neoplasm MP:0002006 9.7 BRAF CAT CTSG DRD2 KIT TYR
3 normal MP:0002873 9.61 ANXA5 BRAF CTSG DRD2 KIT LAMP1
4 pigmentation MP:0001186 9.17 BRAF DCT DRD2 KIT MLANA TYR

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Cisplatin
CISPLATIN PWDR

Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

40
Skin, Endothelial, Lymph Node, Cervix, Tongue, Colon, Bone Marrow

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 863)
# Title Authors PMID Year
1
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. 54 61
19133143 2009
2
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: effects of altering intracellular pH and pink-eyed dilution gene expression. 61 54
16199032 2006
3
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. 54 61
16584089 2006
4
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. 54 61
16087843 2005
5
Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. 61 54
14634018 2004
6
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport. 54 61
12190873 2002
7
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. 61 54
11812790 2002
8
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. 61 54
11775059 2001
9
Translation rate of human tyrosinase determines its N-linked glycosylation level. 61 54
11069924 2001
10
Sensitivity of transplantable melanoma cells to cytokines with regard to their spontaneous apoptosis. 61 54
12107342 2001
11
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. 54 61
10890385 2000
12
Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V. 54 61
10763124 2000
13
Inhibition of melanin synthesis by cystamine in human melanoma cells. 61 54
10620110 2000
14
Inhibitory activity of human lactoferrin and its peptide on chondroitin sulfate A-, CD36-, and thrombospondin-mediated cytoadherence of plasmodium falciparum-infected erythrocytes. 54 61
10381529 1999
15
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. 54 61
9877098 1998
16
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. 61 54
9177196 1997
17
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. 54 61
7535606 1994
18
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs. 61 54
7886004 1994
19
Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. 54 61
8008452 1994
20
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy. 54 61
8110729 1994
21
Malignant melanoma of the nasal cavity. 61 54
7779028 1994
22
Amelanotic melanoma of the oral cavity. 61 54
8410206 1993
23
Tyrosinase gene transcription and its control by melanogenic inhibitors. 54 61
8433001 1993
24
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma. 54 61
8433011 1993
25
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. 54 61
1782361 1991
26
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells. 61 54
1903481 1991
27
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. 54 61
2200526 1990
28
Amelanotic melanoma of the head and neck: analysis of tumor characteristics from the National Cancer Database. 61
33040374 2021
29
The role of UVA radiation in ketoprofen-mediated BRAF-mutant amelanotic melanoma cells death - A study at the cellular and molecular level. 61
33545343 2021
30
Atypical Fibroxanthoma-Like Amelanotic Melanoma: A Diagnostic Challenge. 61
33445655 2021
31
Metastatic amelanotic melanoma to the mandible mimicking benign odontogenic neoplasm. 61
33422427 2021
32
Melanization as unfavorable factor in amelanotic melanoma cell biology. 61
33506271 2021
33
3-O-Methylquercetin from Achyrocline satureioides-cytotoxic activity against A375-derived human melanoma cell lines and its incorporation into cyclodextrins-hydrogels for topical administration. 61
33410099 2021
34
A Rare Case of Oral Mucosal Amelanotic Melanoma in a 77-year-old Immunocompromised Man. 61
33584964 2021
35
Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin. 61
33572631 2021
36
Amelanotic melanoma recurrence diagnosed by fine-needle aspiration cytology: A case report. 61
32558348 2020
37
Effects of curcumin based PDT on the viability and the organization of actin in melanotic (A375) and amelanotic melanoma (C32) - in vitro studies. 61
33113417 2020
38
Amelanotic melanoma presenting as a tongue tumor. 61
33187823 2020
39
Progression of nodular malignant melanoma to metastatic amelanotic melanoma in 3 years: An unusual event. 61
32713107 2020
40
Primary acral amelanotic melanoma: A rare case report. 61
32953113 2020
41
Dermoscopic patterns of intradermal naevi. 61
32715462 2020
42
Evaluation of Radioiodinated Fluoronicotinamide/Fluoropicolinamide-Benzamide Derivatives as Theranostic Agents for Melanoma. 61
32916962 2020
43
Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck. 61
32449432 2020
44
The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. 61
32437906 2020
45
Coexistence of amelanotic melanoma and capillary malformation on the same sole: An unusual case with dermatoscopic findings. 61
32227568 2020
46
Diagnostic Delays in Metastatic Amelanotic Melanoma Presenting as Breast Pain. 61
32756533 2020
47
Trends in pediatric skin cancer. 61
32618791 2020
48
Diagnosis and long-term monitoring of adenomas of the ciliary body epithelium by ultrasound biomicroscopy. 61
32830591 2020
49
Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. 61
31432325 2020
50
Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study. 61
32726478 2020

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 TYRP1 TYR KIT DCT BRAF
2
Show member pathways
11.23 TYRP1 TYR DCT
3 9.56 PARP1 CYCS
4 9.5 TYRP1 TYR DCT

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.63 TYR S100B DCT CTSG CAT BRAF
2 melanosome membrane GO:0033162 9.13 TYRP1 TYR DCT
3 melanosome GO:0042470 9.02 TYRP1 TYR MLANA LAMP1 DCT

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to oxidative stress GO:0034599 9.63 PARP1 CYCS CAT
2 visual learning GO:0008542 9.54 KIT DRD2 BRAF
3 developmental pigmentation GO:0048066 9.43 KIT DCT
4 myeloid progenitor cell differentiation GO:0002318 9.4 KIT BRAF
5 response to blue light GO:0009637 9.32 TYR DCT
6 response to inactivity GO:0014854 9.26 DRD2 CAT
7 melanin biosynthetic process from tyrosine GO:0006583 9.16 TYR DCT
8 melanin biosynthetic process GO:0042438 9.13 TYRP1 TYR DCT
9 pigmentation GO:0043473 9.02 TYRP1 TYR KIT DRD2 DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 VIM TYRP1 TYR S100B PARP1 DRD2
2 monophenol monooxygenase activity GO:0004503 8.62 TYRP1 TYR

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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