MCID: AML004
MIFTS: 38

Ameloblastic Carcinoma

Categories: Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ameloblastic Carcinoma

MalaCards integrated aliases for Ameloblastic Carcinoma:

Name: Ameloblastic Carcinoma 54 60 17 74

Characteristics:

Orphanet epidemiological data:

60
ameloblastic carcinoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare odontological diseases


External Ids:

ICD10 via Orphanet 35 C41.1
UMLS via Orphanet 75 C1314678
Orphanet 60 ORPHA314422
UMLS 74 C1314678

Summaries for Ameloblastic Carcinoma

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 314422Disease definitionAmeloblastic carcinoma is a rare odontogenic tumor characterized by aggressive clinical course and local destruction, occurring in mandible more often than in maxilla. The most common symptom is a rapidly progressing painful swelling, but it may present as a benign cystic lesion or as a large, rapidly growing mass with ulceration, bone resorption and teeth mobility, as well. The tumor may metastasize, most commonly to the cervical lymph nodes and the lungs.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ameloblastic Carcinoma is related to in situ carcinoma and adenoid cystic carcinoma, and has symptoms including pain An important gene associated with Ameloblastic Carcinoma is MKI67 (Marker Of Proliferation Ki-67), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. Affiliated tissues include bone, lymph node and cervix, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 77 Ameloblastic carcinoma is a rare form of odontogenic tumor, one that develops in the jawbones from the... more...

Related Diseases for Ameloblastic Carcinoma

Diseases related to Ameloblastic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.2 CDKN2A KRT14
2 adenoid cystic carcinoma 29.4 KRT14 MKI67 TP63 VIM
3 ameloblastoma 10.6
4 spitz nevus 10.3 CDKN2A MKI67
5 inverted papilloma 10.2 CDKN2A MKI67
6 basaloid squamous cell carcinoma 10.2 CDKN2A KRT14
7 tonsil cancer 10.2 CDKN2A KRT14
8 pre-malignant neoplasm 10.2 CDKN2A KRT14
9 verrucous carcinoma 10.2 CDKN2A SLC2A1
10 oropharynx cancer 10.2 CDKN2A KRT14
11 cervical intraepithelial neoplasia 10.2 CDKN2A MKI67
12 papillary thyroid microcarcinoma 10.2 MKI67 TP63
13 cervix small cell carcinoma 10.2 CDKN2A MAPK8IP2
14 intraneural perineurioma 10.2 KRT14 SLC2A1
15 cellular schwannoma 10.2 CDKN2A SLC2A1
16 limbal stem cell deficiency 10.2 KRT14 TP63
17 malignant peritoneal mesothelioma 10.1 CDKN2A VIM
18 breast fibroadenoma 10.1 KRT14 MKI67
19 lipoadenoma 10.1 KRT14 TP63
20 acral lentiginous melanoma 10.1 CDKN2A VIM
21 pleomorphic liposarcoma 10.1 CDKN2A VIM
22 intravascular papillary endothelial hyperplasia 10.1 HIF1A VIM
23 cervix carcinoma 10.1 CDKN2A MAPK8IP2
24 endocervical adenocarcinoma 10.1 CDKN2A VIM
25 embryonal sarcoma 10.1 MKI67 VIM
26 pinguecula 10.1 KRT14 TP63
27 endometrial adenocarcinoma 10.1 CDKN2A HIF1A MKI67
28 malignant fibroxanthoma 10.1 MKI67 VIM
29 odontoma 10.1 KRT14 VIM
30 chondromyxoid fibroma 10.1 CDKN2A VIM
31 perineurioma 10.1 SLC2A1 VIM
32 meningioma, radiation-induced 10.1 MKI67 VIM
33 actinic keratosis 10.1 CDKN2A TP63
34 syringoma 10.0 TP63 VIM
35 oral leukoplakia 10.0 CDKN2A MKI67 TP63
36 cervix disease 10.0 CDKN2A MAPK8IP2
37 necrotizing sialometaplasia 10.0 CDKN2A MKI67 TP63
38 craniopharyngioma 10.0 KRT14 MKI67
39 cervical squamous cell carcinoma 10.0 CDKN2A MKI67 TP63
40 dermoid cyst 10.0 TP63 VIM
41 dystonia 11, myoclonic 10.0 SLC2A1 VIM
42 mucinous bronchioloalveolar adenocarcinoma 10.0 CDKN2A SDC1
43 mucoepidermoid carcinoma 10.0 KRT14 MKI67 TP63
44 endometrial mucinous adenocarcinoma 10.0 CDKN2A MKI67 VIM
45 ependymoma 10.0 MKI67 VIM
46 papilloma 10.0 CDKN2A KRT14 TP63
47 juvenile glaucoma 10.0 MKI67 SDC1
48 gastrointestinal stromal tumor 10.0 CDKN2A MKI67 VIM
49 familial adenomatous polyposis 1 9.9
50 spinal muscular atrophy 9.9

Graphical network of the top 20 diseases related to Ameloblastic Carcinoma:



Diseases related to Ameloblastic Carcinoma

Symptoms & Phenotypes for Ameloblastic Carcinoma

UMLS symptoms related to Ameloblastic Carcinoma:


pain

MGI Mouse Phenotypes related to Ameloblastic Carcinoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CDKN2A HIF1A KRT14 SDC1 SLC2A1 TP63
2 homeostasis/metabolism MP:0005376 10.03 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 SLC2A1
3 mortality/aging MP:0010768 9.97 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 SLC2A1
4 endocrine/exocrine gland MP:0005379 9.93 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 TP63
5 embryo MP:0005380 9.88 CDKN2A HIF1A SLC2A1 TP63 VIM
6 integument MP:0010771 9.8 CDKN2A HIF1A KRT14 SDC1 TP63
7 neoplasm MP:0002006 9.72 CDKN2A HIF1A KRT14 SDC1 TP63
8 no phenotypic analysis MP:0003012 9.65 CDKN2A MAPK8IP2 MKI67 SLC2A1 TP63
9 reproductive system MP:0005389 9.63 CDKN2A KRT14 MAPK8IP2 SDC1 TP63 VIM
10 respiratory system MP:0005388 9.35 CDKN2A HIF1A KRT14 TP63 VIM
11 vision/eye MP:0005391 9.17 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 TP63

Drugs & Therapeutics for Ameloblastic Carcinoma

Search Clinical Trials , NIH Clinical Center for Ameloblastic Carcinoma

Genetic Tests for Ameloblastic Carcinoma

Anatomical Context for Ameloblastic Carcinoma

MalaCards organs/tissues related to Ameloblastic Carcinoma:

42
Bone, Lymph Node, Cervix, Lung, Breast, Smooth Muscle, Thyroid

Publications for Ameloblastic Carcinoma

Articles related to Ameloblastic Carcinoma:

(show top 50) (show all 140)
# Title Authors Year
1
Ameloblastic Carcinoma In Situ: Review of Literature and a Case Presentation in a Pediatric Patient. ( 29715060 )
2019
2
Proton Beam Therapy for Ameloblastic Carcinoma of the Maxilla: Report of a Rare Case. ( 30240599 )
2019
3
The use of radiation therapy in the definitive management of ameloblastic carcinoma: a case report. ( 30393089 )
2019
4
Huge ameloblastic carcinoma of the mandible with metastases treated in several different ways. ( 30600107 )
2019
5
Immunohistochemical Profile of Ameloblastic Carcinoma Arising from an Amyloid-Producing Odontogenic Tumour in a Miniature Dachshund. ( 30691607 )
2019
6
Spindle-cell variant of ameloblastic carcinoma: a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression. ( 30928327 )
2019
7
Ameloblastic carcinoma ex ameloblastoma of the maxilla. ( 30967726 )
2019
8
Ameloblastic carcinoma: A rare case with diagnostic dilemma. ( 30967729 )
2019
9
Primary Ameloblastic Carcinoma of the Neck. ( 30995861 )
2019
10
Cervicopectoral flap as an adequate decision for advanced ameloblastic carcinoma. ( 28984029 )
2018
11
Ameloblastic carcinoma with metastasis to the parotid gland. ( 29124909 )
2018
12
Reconnoitre ameloblastic carcinoma: A prognostic update. ( 29362117 )
2018
13
Secondary Ameloblastic Carcinoma of Mandible with Pulmonary Metastasis. ( 29866242 )
2018
14
Literature review of 86 cases of mandibular ameloblastic carcinoma. ( 29937652 )
2018
15
Primary ameloblastic carcinoma: literature review with case series. ( 30509051 )
2018
16
Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma. ( 30596059 )
2018
17
Massive Skull Base Ameloblastic Carcinoma with Intracranial Extension. ( 27560532 )
2017
18
A Rare Case Report of Spindle Cell Ameloblastic Carcinoma Involving the Mandible. ( 28274070 )
2017
19
Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases. ( 28600599 )
2017
20
Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region. ( 28717298 )
2017
21
Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma. ( 28729769 )
2017
22
Spindle cell variant of ameloblastic carcinoma: a case report and literature review. ( 26238174 )
2016
23
Single-Fraction Helical Tomotherapy for Ameloblastic Carcinoma. ( 26272005 )
2016
24
Ameloblastic carcinoma (secondary type) with extensive squamous differentiation areas and dedifferentiated regions. ( 26768075 )
2016
25
Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy. ( 26796877 )
2016
26
Ameloblastic carcinoma of the maxilla: a report of two cases and a review of the literature. ( 26904494 )
2016
27
Immunohistochemical expression of K6, K8, K16, K17, K19, maspin, syndecan-1 (CD138), α-SMA, and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations. ( 26972539 )
2016
28
Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma. ( 27020375 )
2016
29
Ameloblastic carcinoma: a Brazilian collaborative study of 17 cases. ( 27195964 )
2016
30
Ameloblastic Carcinoma: A Report of Three Cases. ( 27891485 )
2016
31
Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature. ( 28105148 )
2016
32
Spindle-cell ameloblastic carcinoma of the maxilla with adenoid cystic carcinoma-like areas: A new variant? ( 26549079 )
2015
33
Ameloblastic carcinoma with features of ghost cell odontogenic carcinoma in a patient with suspected Gardner syndrome. ( 25434693 )
2015
34
Primary ameloblastic carcinoma of the maxilla: A case report and literature review. ( 25436009 )
2015
35
Ameloblastic carcinoma of the mandible manifesting as an infected odontogenic cyst. ( 25574726 )
2015
36
Expression of the transcription factor PITX2 in ameloblastic carcinoma. ( 25791324 )
2015
37
Spindle cell variant of ameloblastic carcinoma: a case report and review of literature. ( 25939122 )
2015
38
Ameloblastic Carcinoma. ( 26126621 )
2015
39
Ameloblastic Carcinoma: A Case Report. ( 26393226 )
2015
40
Immunoexpression of Ki-67, MCM2, and MCM3 in Ameloblastoma and Ameloblastic Carcinoma and Their Correlations with Clinical and Histopathological Patterns. ( 26823641 )
2015
41
Ameloblastic carcinoma: An effort to abridge this diagnostic challenge! ( 26853419 )
2015
42
Identification of proteins with increased levels in ameloblastic carcinoma. ( 24485979 )
2014
43
Ameloblastic carcinoma: Report of a rare case. ( 24579073 )
2014
44
Evaluation of SOX2 as a potential marker for ameloblastic carcinoma. ( 24603057 )
2014
45
Ameloblastic carcinoma developing in preexisting ameloblastoma with a mutation of the p53 gene: a case report. ( 24906942 )
2014
46
Ameloblastic carcinoma: A clinicopathologic dilemma - Report of two cases with total review of literature from 1984 to 2012. ( 24987603 )
2014
47
Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature. ( 25013517 )
2014
48
Prominent response with helical tomotherapy in recurrent ameloblastic carcinoma of maxillary sinus: a case report. ( 25027948 )
2014
49
Usefulness of 11C-methionine positron emission tomography for detecting intracranial ameloblastic carcinoma: A case report. ( 25202358 )
2014
50
Ameloblastic carcinoma: A case series. ( 25210376 )
2014

Variations for Ameloblastic Carcinoma

Cosmic variations for Ameloblastic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM24747 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 0
2 COSM5673 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 0
3 COSM476 BRAF bone,mandible,carcinoma,NS c.1799T>A p.V600E 7:140753336-140753336 0

Expression for Ameloblastic Carcinoma

Search GEO for disease gene expression data for Ameloblastic Carcinoma.

Pathways for Ameloblastic Carcinoma

Pathways related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 CDKN2A TP63 VIM
2 11.73 CDKN2A MKI67 TP63 VIM
3 11.22 HIF1A SLC2A1
4 11.18 HIF1A SLC2A1
5 10.82 HIF1A SLC2A1
6 10.53 CDKN2A HIF1A SLC2A1
7
Show member pathways
10.5 CDKN2A TP63

GO Terms for Ameloblastic Carcinoma

Cellular components related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 HIF1A MAPK8IP2 SDC1 TP63

Biological processes related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.8 HIF1A SDC1 VIM

Molecular functions related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 CDKN2A HIF1A KRT14 MAPK8IP2 MKI67 SDC1
2 protein domain specific binding GO:0019904 9.33 HIF1A TP63 VIM
3 p53 binding GO:0002039 9.32 HIF1A TP63
4 protein C-terminus binding GO:0008022 8.96 MKI67 SDC1
5 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Ameloblastic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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