MCID: AML004
MIFTS: 40

Ameloblastic Carcinoma

Categories: Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ameloblastic Carcinoma

MalaCards integrated aliases for Ameloblastic Carcinoma:

Name: Ameloblastic Carcinoma 20 58 17 70

Characteristics:

Orphanet epidemiological data:

58
ameloblastic carcinoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare odontological diseases


External Ids:

ICD10 via Orphanet 33 C41.1
UMLS via Orphanet 71 C1314678
Orphanet 58 ORPHA314422
UMLS 70 C1314678

Summaries for Ameloblastic Carcinoma

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 314422 Definition A rare odontogenic tumor characterized by aggressive clinical course and local destruction, occurring in mandible more often than in maxilla. The most common symptom is a rapidly progressing painful swelling, but it may present as a benign cystic lesion or as a large, rapidly growing mass with ulceration, bone resorption and teeth mobility, as well. The tumor may metastasize, most commonly to the cervical lymph nodes and the lungs.

MalaCards based summary : Ameloblastic Carcinoma is related to squamous cell carcinoma and basal cell carcinoma, and has symptoms including pain An important gene associated with Ameloblastic Carcinoma is MKI67 (Marker Of Proliferation Ki-67), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. Affiliated tissues include bone, breast and lung, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 73 Ameloblastic carcinoma is a rare form of malignant odontogenic tumor, that develops in the jawbones from... more...

Related Diseases for Ameloblastic Carcinoma

Diseases related to Ameloblastic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.3 TP63 MKI67 HIF1A CDKN2A
2 basal cell carcinoma 29.3 TP63 MKI67 KRT14 CDKN2A
3 adenoid cystic carcinoma 28.8 VIM TP63 KRT14 HIF1A CDKN2A
4 ameloblastoma 10.9
5 rare tumor 10.4
6 bone resorption disease 10.3
7 rare odontogenic tumor 10.3
8 spitz nevus 10.3 MKI67 CDKN2A
9 intracranial meningioma 10.3 MKI67 CDKN2A
10 soft tissue sarcoma 10.2 MKI67 HIF1A
11 trachea carcinoma in situ 10.2 KRT14 CDKN2A
12 cervical intraepithelial neoplasia 10.2 MKI67 CDKN2A
13 squamous cell papilloma 10.2 KRT14 CDKN2A
14 inverted papilloma 10.2 MKI67 CDKN2A
15 borst-jadassohn intraepidermal carcinoma 10.2 KRT14 CDKN2A
16 endometrial mucinous adenocarcinoma 10.2 VIM CDKN2A
17 mucinous adenocarcinoma 10.2 VIM CDKN2A
18 embryonal sarcoma 10.1 VIM MKI67
19 intravascular papillary endothelial hyperplasia 10.1 VIM HIF1A
20 clear cell meningioma 10.1 VIM MKI67
21 bile duct adenoma 10.1 VIM CDKN2A
22 desmoid tumor 10.1 MKI67 CDKN2A
23 chondromyxoid fibroma 10.1 VIM CDKN2A
24 adenosarcoma 10.1 VIM MKI67
25 tonsil cancer 10.1 KRT14 CDKN2A
26 acral lentiginous melanoma 10.1 VIM CDKN2A
27 pleomorphic liposarcoma 10.1 VIM CDKN2A
28 odontoma 10.1 VIM KRT14
29 melanoma in congenital melanocytic nevus 10.1 MKI67 CDKN2A
30 sarcomatoid mesothelioma 10.1 VIM CDKN2A
31 perivascular epithelioid cell tumor 10.1 VIM CDKN2A
32 spiradenoma 10.1 VIM KRT14
33 lung giant cell carcinoma 10.1 VIM CDKN2A
34 paresthesia 10.1
35 endocervical carcinoma 10.1 VIM CDKN2A
36 epithelial-myoepithelial carcinoma 10.1 VIM KRT14
37 myoepithelial carcinoma 10.1 VIM KRT14
38 glomus tumor 10.1 VIM CDKN2A
39 ceruminous adenocarcinoma 10.1 SLC2A1 KRT14
40 benign mesothelioma 10.1 VIM CDKN2A
41 collecting duct carcinoma 10.1 VIM CDKN2A
42 endocervical adenocarcinoma 10.0 VIM CDKN2A
43 adenoid squamous cell carcinoma 10.0 VIM SDC1
44 keratoacanthoma 10.0 MKI67 KRT14
45 capillary hemangioma 10.0 SLC2A1 HIF1A
46 ischemic fasciitis 10.0 KRT14 HIF1A CDKN2A
47 necrotizing sialometaplasia 10.0 TP63 MKI67
48 oral leukoplakia 10.0 TP63 MKI67
49 papillary thyroid microcarcinoma 10.0 TP63 MKI67
50 plasma cell leukemia 10.0 SDC1 CDKN2A

Graphical network of the top 20 diseases related to Ameloblastic Carcinoma:



Diseases related to Ameloblastic Carcinoma

Symptoms & Phenotypes for Ameloblastic Carcinoma

UMLS symptoms related to Ameloblastic Carcinoma:


pain

MGI Mouse Phenotypes related to Ameloblastic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.01 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 SLC2A1
2 cellular MP:0005384 10 CDKN2A HIF1A KRT14 SDC1 SLC2A1 TP63
3 mortality/aging MP:0010768 9.97 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 SLC2A1
4 endocrine/exocrine gland MP:0005379 9.91 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 TP63
5 neoplasm MP:0002006 9.72 CDKN2A HIF1A KRT14 SDC1 TP63
6 no phenotypic analysis MP:0003012 9.65 CDKN2A MAPK8IP2 MKI67 SLC2A1 TP63
7 reproductive system MP:0005389 9.63 CDKN2A KRT14 MAPK8IP2 SDC1 TP63 VIM
8 respiratory system MP:0005388 9.35 CDKN2A HIF1A KRT14 TP63 VIM
9 vision/eye MP:0005391 9.17 CDKN2A HIF1A KRT14 MAPK8IP2 SDC1 TP63

Drugs & Therapeutics for Ameloblastic Carcinoma

Search Clinical Trials , NIH Clinical Center for Ameloblastic Carcinoma

Genetic Tests for Ameloblastic Carcinoma

Anatomical Context for Ameloblastic Carcinoma

MalaCards organs/tissues related to Ameloblastic Carcinoma:

40
Bone, Breast, Lung, Skin, Smooth Muscle, Thyroid, Tonsil

Publications for Ameloblastic Carcinoma

Articles related to Ameloblastic Carcinoma:

(show top 50) (show all 241)
# Title Authors PMID Year
1
Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma. 61
33733498 2021
2
Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma. 61
33037799 2021
3
Clinico-pathological study of malignant odontogenic tumours from a national referral centre. 61
33736630 2021
4
Rare Ameloblastic Carcinoma Metastasis to the Cervical Spine: A Case Report. 61
33611519 2021
5
Characterization of high risk human papilloma virus genotypes associated with oropharyngeal cancers in a Nigerian population. 61
33777308 2021
6
Findings in bone scintigraphy with [99mTc] Tc-MDP of a mandibular ameloblastic carcinoma. 61
33576481 2021
7
Report of a Rare Case of Spindle Cell Ameloblastic Carcinoma and the Diagnostic Utility of Immunohistochemistry. 61
33480603 2021
8
Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more aggressive behaviour. 61
32623516 2020
9
Ameloblastic carcinoma of the mandible: A case report. 61
33409146 2020
10
Study on clinical and biological characteristics of ameloblastic carcinoma. 61
33176823 2020
11
Proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for an extremely rapid growing recurrent ameloblastic carcinoma: A case report. 61
32802330 2020
12
BDNF/TrkB/Akt Signaling Pathway Epithelial Odontogenic Tumors and Keratocyst: An Immunohistochemical Study Comparative With Dental Germs. 61
32941187 2020
13
Challenges in the diagnostics and treatment of ectopic ameloblastic carcinoma: a case report. 61
32643344 2020
14
Prognostic evaluation of metastasizing ameloblastoma: A systematic review of reported cases in literature. 61
32659412 2020
15
Primary Ameloblastic Carcinoma of the Neck. 61
30995861 2020
16
Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma. 61
32113465 2020
17
Ameloblastic Carcinoma with Calcification: A Rare Case Report in the Mandible and Literature Review. 61
33110663 2020
18
Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature. 61
32774938 2020
19
Histopathological features of malignant craniopharyngioma: Case report and literature review. 61
31661068 2020
20
A Rare Presentation of Ameloblastic Carcinoma of the Sinus Cavity and Skull Base. 61
31903302 2019
21
Ameloblastic carcinoma: Clinicopathological analysis of 18 cases and a systematic review. 61
31444935 2019
22
Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT. 61
31674718 2019
23
Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report. 61
29974411 2019
24
Recurrent ameloblastoma 24 years after hemimandibulectomy: A case report and review of literature. 61
31939379 2019
25
Calretinin expression in odontogenic cysts and odontogenic tumors and the possible role of calretinin in pathogenesis of ameloblastoma. 61
31942113 2019
26
Spindle-cell variant of ameloblastic carcinoma: a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression. 61
30928327 2019
27
Ameloblastic carcinoma: A diagnostic dilemma. 61
31361256 2019
28
Misdiagnosis of ameloblastoma in a patient with clear cell odontogenic carcinoma: a case report. 61
31106140 2019
29
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. 61
30692057 2019
30
Ameloblastic carcinoma ex ameloblastoma of the maxilla. 61
30967726 2019
31
Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992-2016. 61
30448231 2019
32
Ameloblastic carcinoma: A rare case with diagnostic dilemma. 61
30967729 2019
33
Huge ameloblastic carcinoma of the mandible with metastases treated in several different ways. 61
30600107 2019
34
The use of radiation therapy in the definitive management of ameloblastic carcinoma: a case report. 61
30393089 2019
35
Immunohistochemical Profile of Ameloblastic Carcinoma Arising from an Amyloid-Producing Odontogenic Tumour in a Miniature Dachshund. 61
30691607 2019
36
Ameloblastic Carcinoma In Situ: Review of Literature and a Case Presentation in a Pediatric Patient. 61
29715060 2019
37
Proton Beam Therapy for Ameloblastic Carcinoma of the Maxilla: Report of a Rare Case. 61
30240599 2019
38
Odontogenic tumors: A 35-year retrospective study of 250 cases in an Indian (Maharashtra) teaching institute. 61
30693892 2018
39
Secondary Ameloblastic Carcinoma of Mandible with Pulmonary Metastasis. 61
29866242 2018
40
Cervicopectoral flap as an adequate decision for advanced ameloblastic carcinoma. 61
28984029 2018
41
Ameloblastic carcinoma with metastasis to the parotid gland. 61
29124909 2018
42
Reconnoitre ameloblastic carcinoma: A prognostic update. 61
29362117 2018
43
Literature review of 86 cases of mandibular ameloblastic carcinoma. 61
29937652 2018
44
Primary ameloblastic carcinoma: literature review with case series. 61
30509051 2018
45
Ameloblastic carcinoma: a clinicopathologic analysis of cases seen in a Nigerian Teaching Hospital and review of literature. 61
31497184 2018
46
Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma. 61
30596059 2018
47
Epidemiological and Clinicopathological Analysis of 92 Odontogenic Tumors: A 5-year Retrospective Study. 61
29109321 2017
48
[Primary ameloblastic carcinoma of maxilla with extensive squamous differentiation areas of dedifferentiation: report of a case]. 61
29050083 2017
49
Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases. 61
28600599 2017
50
Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region. 61
28717298 2017

Variations for Ameloblastic Carcinoma

Cosmic variations for Ameloblastic Carcinoma:

9 (show top 50) (show all 82)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM150563774 BRAF bone,mandible,carcinoma,ameloblastic carcinoma c.1799T>A p.V600E 7:140753336-140753336 4
2 COSM149385292 BRAF bone,mandible,carcinoma,ameloblastic carcinoma c.1919T>A p.V640E 7:140753336-140753336 4
3 COSM88803061 BRAF bone,mandible,carcinoma,ameloblastic carcinoma c.1919T>A p.V640E 7:140753336-140753336 4
4 COSM109701911 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
5 COSM111894724 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
6 COSM149958312 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
7 COSM150659747 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
8 COSM109692244 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
9 COSM150275343 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
10 COSM149302636 CTNNB1 bone,mandible,carcinoma,NS c.-147A>T p.? 3:41224075-41224075 3
11 COSM151491760 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
12 COSM102462265 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
13 COSM146878993 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
14 COSM150733948 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
15 COSM150872450 CTNNB1 bone,mandible,carcinoma,NS c.-8-451A>T p.? 3:41224075-41224075 3
16 COSM150913849 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
17 COSM151558787 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
18 COSM150102746 CTNNB1 bone,mandible,carcinoma,NS c.-147A>T p.? 3:41224075-41224075 3
19 COSM150819016 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
20 COSM151563013 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
21 COSM110188886 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
22 COSM149384593 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
23 COSM146255663 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
24 COSM151827260 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
25 COSM150089257 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
26 COSM149585436 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
27 COSM150868260 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
28 COSM111887421 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
29 COSM150452908 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
30 COSM149597162 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
31 COSM150918789 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
32 COSM111036764 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
33 COSM151343727 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
34 COSM151496166 CTNNB1 bone,mandible,carcinoma,NS c.-147A>T p.? 3:41224075-41224075 3
35 COSM102390032 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
36 COSM111900702 CTNNB1 bone,mandible,carcinoma,NS c.-147A>T p.? 3:41224075-41224075 3
37 COSM151830103 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
38 COSM149291305 CTNNB1 bone,maxilla,carcinoma,NS c.77C>A p.S26Y 3:41224610-41224610 3
39 COSM149489582 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
40 COSM150532857 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
41 COSM150284260 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
42 COSM151749012 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
43 COSM150526529 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
44 COSM150737820 CTNNB1 bone,mandible,carcinoma,NS c.-147A>T p.? 3:41224075-41224075 3
45 COSM151754082 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
46 COSM150151582 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
47 COSM149395466 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
48 COSM146243773 CTNNB1 bone,maxilla,carcinoma,NS c.98C>A p.S33Y 3:41224610-41224610 3
49 COSM151980192 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3
50 COSM150462203 CTNNB1 bone,mandible,carcinoma,NS c.7A>T p.T3S 3:41224075-41224075 3

Expression for Ameloblastic Carcinoma

Search GEO for disease gene expression data for Ameloblastic Carcinoma.

Pathways for Ameloblastic Carcinoma

Pathways related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 VIM TP63 CDKN2A
2 11.73 VIM TP63 MKI67 CDKN2A
3 10.82 SLC2A1 HIF1A
4 10.53 SLC2A1 HIF1A CDKN2A
5
Show member pathways
10.5 TP63 CDKN2A

GO Terms for Ameloblastic Carcinoma

Cellular components related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.13 MKI67 HIF1A CDKN2A
2 protein-containing complex GO:0032991 9.02 TP63 SDC1 MAPK8IP2 HIF1A CDKN2A

Biological processes related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.8 VIM SDC1 HIF1A

Molecular functions related to Ameloblastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.43 VIM TP63 HIF1A
2 MDM2/MDM4 family protein binding GO:0097371 9.16 TP63 CDKN2A
3 keratin filament binding GO:1990254 8.96 VIM KRT14
4 p53 binding GO:0002039 8.8 TP63 HIF1A CDKN2A

Sources for Ameloblastic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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