MCID: AML029
MIFTS: 50

Ameloblastoma

Categories: Rare diseases, Oral diseases, Cancer diseases

Aliases & Classifications for Ameloblastoma

MalaCards integrated aliases for Ameloblastoma:

Name: Ameloblastoma 12 53 59 55 15 73
Adenoameloblastoma 53 73
Adenomatoid Odontogenic Tumor 53
Aot 53

Characteristics:

Orphanet epidemiological data:

59
ameloblastoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare odontological diseases


External Ids:

Disease Ontology 12 DOID:0050894
Orphanet 59 ORPHA314419
ICD10 via Orphanet 34 D16.5 D16.4
UMLS via Orphanet 74 C0002448

Summaries for Ameloblastoma

NIH Rare Diseases : 53 Ameloblastoma is a rare, noncancerous (benign) tumor that typically develops in the jaw near the molars. It originates in the cells that form the enamel that protects your teeth. The condition most often occurs in adults in their 30s and 40s, though it can occur at any age. In many cases, the first sign is painless swelling in the jaw. While it can be very aggressive, these tumors are rarely found outside of the jaw. Treatment is complete surgical removal of the affected tissue.

MalaCards based summary : Ameloblastoma, also known as adenoameloblastoma, is related to calcifying epithelial odontogenic tumor and keratocystic odontogenic tumor. An important gene associated with Ameloblastoma is AMBN (Ameloblastin), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. The drugs Hydrocortisone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary, and related phenotypes are growth/size/body region and craniofacial

Disease Ontology : 12 A cell type benign neoplasm that has material basis in odontogenic epithelium.

Wikipedia : 76 Ameloblastoma (from the early English word amel, meaning enamel + the Greek word blastos, meaning germ)... more...

Related Diseases for Ameloblastoma

Diseases related to Ameloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 calcifying epithelial odontogenic tumor 32.3 AMBN KRT8 PTCH1
2 keratocystic odontogenic tumor 30.6 GLI1 PTCH1 SMO TNFSF11
3 odontoma 29.6 KRT14 KRT18 KRT8 PCNA
4 basal cell carcinoma 29.4 GLI1 KRT14 KRT8 PTCH1 SMO
5 basaloid squamous cell carcinoma 29.2 KRT14 KRT8
6 adenoid cystic carcinoma 29.0 KRT14 PCNA SERPINA3
7 bone ameloblastoma 11.9
8 schimmelpenning-feuerstein-mims syndrome 10.9
9 basal cell carcinoma, multiple 10.8 PTCH1 SMO
10 pigmented basal cell carcinoma 10.7 KRT14 PTCH1
11 apocrine sweat gland neoplasm 10.5 KRT14 KRT8
12 nodular medulloblastoma 10.5 GLI1 PTCH1
13 neurenteric cyst 10.4 KRT18 KRT8
14 proliferating trichilemmal cyst 10.4 KRT18 KRT8
15 cutaneous adenocystic carcinoma 10.4 KRT18 KRT8
16 amelogenesis imperfecta, type iiia 10.3 AMBN MMP20
17 ameloblastic carcinoma 10.3
18 basal cell nevus syndrome 10.3 GLI1 PTCH1 SMO
19 cryptogenic cirrhosis 10.3 KRT18 KRT8
20 hypocalcified amelogenesis imperfecta 10.3 AMBN MMP20
21 brooke-spiegler syndrome 10.3 KRT14 KRT8 PTCH1
22 pleomorphic carcinoma 10.3 KRT18 KRT8
23 benign meningioma 10.3 PCNA TERT
24 mucinous tubular and spindle renal cell carcinoma 10.3 KRT18 KRT8
25 nasal cavity squamous cell carcinoma 10.3 KRT8 MMP2
26 papillary ependymoma 10.2 KRT18 KRT8
27 papilloma 10.2 KRT14 KRT8 PCNA
28 adenoiditis 10.2
29 lymphoepithelioma-like carcinoma 10.2 KRT18 KRT8
30 teeth hard tissue disease 10.1 AMBN MMP20 TNFSF11
31 skin melanoma 10.1 MMP2 PCNA TERT
32 cervical clear cell adenocarcinoma 10.1 KRT14 KRT18 KRT8
33 intraneural perineurioma 10.1 KRT14 KRT18 KRT8
34 basal cell carcinoma 1 10.1
35 primary cutaneous amyloidosis 10.0 KRT14 KRT18 KRT8
36 grade iii astrocytoma 10.0 BSG MMP2 PCNA
37 lung giant cell carcinoma 10.0 KRT18 MMP2
38 meningioma, familial 9.9 PCNA PTCH1 TERT
39 squamous cell carcinoma 9.9
40 vitreoretinopathy, neovascular inflammatory 9.9
41 prostatitis 9.9
42 nevus, epidermal 9.9
43 aneurysmal bone cysts 9.9
44 epulis 9.9
45 conjunctivitis 9.9
46 aneurysm 9.9
47 endotheliitis 9.9
48 gastric squamous cell carcinoma 9.8 GLI1 SERPINA3
49 adamantinoma of long bones 9.8 MMP2 TERT TNFSF10
50 lipoadenoma 9.7 KRT14 SERPINA3

Graphical network of the top 20 diseases related to Ameloblastoma:



Diseases related to Ameloblastoma

Symptoms & Phenotypes for Ameloblastoma

MGI Mouse Phenotypes related to Ameloblastoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 MMP20 PCNA KRT14 PTCH1 AMBN KRT18
2 craniofacial MP:0005382 10.1 MMP20 KRT14 PTCH1 AMBN MMP2 GLI1
3 mortality/aging MP:0010768 10.1 GLI1 PCNA KRT14 KRT18 KRT8 BSG
4 endocrine/exocrine gland MP:0005379 10.06 GLI1 PCNA KRT14 BSG TERT TNFSF10
5 hematopoietic system MP:0005397 10.06 PCNA KRT14 KRT8 BSG MMP2 TERT
6 immune system MP:0005387 10.02 MMP2 PCNA KRT14 KRT8 BSG TERT
7 digestive/alimentary MP:0005381 9.95 GLI1 KRT14 KRT8 TERT PTCH1 SMO
8 neoplasm MP:0002006 9.86 KRT14 PTCH1 AMBN MMP2 GLI1 TERT
9 reproductive system MP:0005389 9.76 GLI1 PCNA KRT14 KRT8 BSG TERT
10 respiratory system MP:0005388 9.56 KRT14 BSG MMP2 GLI1 TERT PTCH1
11 skeleton MP:0005390 9.17 MMP2 AMBN TERT TNFSF10 PTCH1 TNFSF11

Drugs & Therapeutics for Ameloblastoma

Drugs for Ameloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
4 Anesthetics Phase 4
5 Anti-Inflammatory Agents Phase 4,Phase 1
6 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Not Applicable
7 Cortisol succinate Phase 4
8 glucocorticoids Phase 4,Phase 1
9 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
10 Hormones Phase 4,Phase 3,Phase 2,Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
12 Hydrocortisone 17-butyrate 21-propionate Phase 4
13 Hydrocortisone acetate Phase 4
14 Hydrocortisone-17-butyrate Phase 4
15
Diazoxide Approved Phase 3,Phase 2 364-98-7 3019
16
Exenatide Approved, Investigational Phase 3,Phase 2 141758-74-9 15991534
17 Antihypertensive Agents Phase 3,Phase 2
18 Vasodilator Agents Phase 3,Phase 2
19 Hypoglycemic Agents Phase 3,Phase 2
20 Incretins Phase 3,Phase 2
21 glucagon Phase 3
22 Glucagon-Like Peptide 1 Phase 3
23
Metformin Approved Phase 2 657-24-9 14219 4091
24
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
25
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
26
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
27
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
28
Memantine Approved, Investigational Phase 2 19982-08-2 4054
29
Peginterferon alfa-2b Approved Phase 2 99210-65-8, 215647-85-1
30
Methionine Approved, Nutraceutical Phase 2 63-68-3 6137
31
Camptothecin Experimental Phase 2 7689-03-4
32 insulin Phase 2
33 Insulin, Globin Zinc Phase 2
34 Antineoplastic Agents, Phytogenic Phase 2
35 topoisomerase I inhibitors Phase 2
36 Topoisomerase Inhibitors Phase 2
37 Anti-Infective Agents Phase 2,Phase 1
38 Protein Kinase Inhibitors Phase 2
39 Oxytocics Phase 2
40 Antiparkinson Agents Phase 2
41 Dopamine Agents Phase 2
42 Excitatory Amino Acid Antagonists Phase 2
43 Excitatory Amino Acids Phase 2
44 Neurotransmitter Agents Phase 2
45 Antiviral Agents Phase 2
46 Interferon-alpha Phase 2
47 interferons Phase 2
48 Fluorodeoxyglucose F18 Phase 2
49 Radiopharmaceuticals Phase 2,Not Applicable
50
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
2 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
3 Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions Completed NCT00306683 Phase 3 DIAZOXIDE
4 Multicentre Double-blind Randomized Clinical Trial Assessing Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy Recruiting NCT02860923 Phase 3 Exenatide;Placebo
5 Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy Completed NCT00892073 Phase 2 Diazoxide;Metformin
6 An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury Completed NCT02063295 Phase 2 ZGN-440 sterile diluent;ZGN-440 for injectable suspension
7 Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor Completed NCT01484873 Phase 2 Exenatide
8 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
9 Dabrafenib and Trametinib in Treating Patients With BRAF Mutated Ameloblastoma Recruiting NCT02367859 Phase 2 Dabrafenib;Trametinib
10 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib
11 A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection Recruiting NCT02792582 Phase 2
12 Intranasal Oxytocin in Hypothalamic Obesity Recruiting NCT02849743 Phase 2 Syntocinon;Placebo (for Syntocinon)
13 Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors Recruiting NCT03194906 Phase 2 Memantine
14 Methionine PET/CT Studies In Patients With Cancer Recruiting NCT00840047 Phase 2 Methionine
15 Management of Pediatric Craniopharyngioma by a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma) Active, not recruiting NCT02842723 Phase 2
16 Peginterferon Alfa-2b in Treating Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery Active, not recruiting NCT01964300 Phase 2
17 A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection Active, not recruiting NCT01419067 Phase 2 ^1^8F-fluorodeoxyglucose;^1^1C-methionine
18 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
19 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
20 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
21 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
22 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
23 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
24 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia Completed NCT00053963 Phase 1 romidepsin
27 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
28 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
29 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
30 Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma Unknown status NCT00949156
31 Social Participation After Childhood Craniopharyngioma Completed NCT03139526
32 1.5T Intraoperative MR Imaging in Craniopharyngiomas Completed NCT01206543 Not Applicable
33 Weight Gain in Surgically Treated Adult-onset Craniopharyngioma Completed NCT01968603
34 Sleep Wake and Melatonin Pattern in Craniopharyngioma Completed NCT01881854
35 Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma Completed NCT00258453 Not Applicable
36 Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients Recruiting NCT03330080
37 Prospective Study of Children and Adolescents With Craniopharyngioma Recruiting NCT01272622 Not Applicable
38 An Investigation of Pituitary Tumors and Related Hypothalmic Disorders Recruiting NCT00001595
39 Molecular-Guided Therapy for Childhood Cancer Recruiting NCT02162732 Not Applicable
40 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Active, not recruiting NCT00919750
41 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Ameloblastoma

Genetic Tests for Ameloblastoma

Anatomical Context for Ameloblastoma

MalaCards organs/tissues related to Ameloblastoma:

41
Brain, Bone, Pituitary, T Cells, Spinal Cord, Lung, Endothelial

Publications for Ameloblastoma

Articles related to Ameloblastoma:

(show top 50) (show all 396)
# Title Authors Year
1
Ameloblastoma with adenoid features: A series of eight cases. ( 29799420 )
2018
2
Fine-needle aspiration cytology as a useful diagnostic adjunct in the management of ameloblastoma: A report of four cases. ( 29937671 )
2018
3
Evaluation of Midkine Expression in Dentigerous Cysts, Odontogenic Keratocysts and Different Types of Ameloblastoma. ( 29383694 )
2018
4
Marsupialization of mandibular cystic ameloblastoma: Retrospective study of 7 years. ( 29756338 )
2018
5
Expression profile of polycomb group proteins in odontogenic keratocyst and ameloblastoma. ( 29415809 )
2018
6
Bilocular unicystic ameloblastoma of the mandible in a 9 yr old child - A diagnostic and management dilemma. ( 29942110 )
2018
7
Fascin Expression in Ameloblastoma, Odontogenic Keratocyst and Dentigerous Cyst. ( 29926463 )
2018
8
Elevated hydrostatic pressure promotes ameloblastoma cell invasion through up-regulation of MMP-2 and MMP-9 expression via Wnt/I^-catenin signalling. ( 29964338 )
2018
9
Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography. ( 29791200 )
2018
10
Recurrent Ameloblastoma: A Surgical Challenge. ( 29682361 )
2018
11
Oral peripheral ameloblastoma: A retrospective series study of 25 cases. ( 29680843 )
2018
12
Expression of TP53 and IL-1I+ in unicystic ameloblastoma predicts the efficacy of marsupialization treatment. ( 29419674 )
2018
13
Prenatal diagnosis of unicystic ameloblastoma. ( 29108911 )
2018
14
Comparative Study of the Minichromosome Maintenance Proteins Complex (MCM 4/5/6) in Ameloblastoma and Unicystic Ameloblastoma. ( 29845895 )
2018
15
Granular cell type of ameloblastoma. ( 29922343 )
2018
16
Expression of ameloblastin in the human tooth germ and ameloblastoma. ( 29974993 )
2018
17
Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor. ( 29657523 )
2018
18
Unicystic ameloblastoma: Analysis of 370 cases in a single center in Sri Lanka. ( 29858565 )
2018
19
Rate of Relapse After Enucleation of Solid/Multicystic Ameloblastoma Followed by Piezoelectric or Conventional Peripheral Ostectomy. ( 29419594 )
2018
20
Sinonasal Ameloblastoma. ( 29846904 )
2018
21
Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report. ( 29974411 )
2018
22
Brain ameloblastoma: metastasis or local extension case report and physipathological reflexion. ( 29747056 )
2018
23
Oral and masticatory rehabilitation using osseointegrated dental implants after resective treatment of multicystic ameloblastoma in the lower jaw with a fibula graft. ( 29442096 )
2018
24
Treatment of Mandibular Ameloblastoma Involving the Mandibular Condyle: Resection and Concomitant Reconstruction With a Custom Hybrid Total Joint Prosthesis and Iliac Bone Graft. ( 29381612 )
2018
25
The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study. ( 29274152 )
2018
26
Long-term outcome of patients with or without osseointegrated implants after resection of mandibular ameloblastoma and reconstruction with vascularized bone graft: Functional assessment and quality of life. ( 29656899 )
2018
27
Expression of proteoglycans in two types of ameloblastoma: novel Immunohistochemical findings. ( 29921372 )
2018
28
Dr Bloodgood's Contribution to Peripheral Ameloblastoma. ( 29730060 )
2018
29
Conservative management (marsupialization) of unicystic ameloblastoma: literature review and a case report. ( 29302587 )
2017
30
I(125) brachytherapy guided by individual three-dimensional printed plates for recurrent ameloblastoma of the skull base. ( 28669443 )
2017
31
The clinicopathologic relevance of RECK gene polymorphisms in ameloblastoma. ( 28340422 )
2017
32
Prognostic significance of hMSH2, hMSH3, and hMSH6 expression in ameloblastoma. ( 28734697 )
2017
33
Conservative vs Radical Approach for the Treatment of Solid/Multicystic Ameloblastoma: A Systematic Review and Meta-analysis of the Last Decade. ( 28748232 )
2017
34
Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors. ( 27780042 )
2017
35
The anecdote of viral etiopathogenia in ameloblastoma and odontogenic keratocyst: Why don't we let it go? ( 28706783 )
2017
36
Evaluation of Tumour Associated Macrophages and Angiogenesis in Ameloblastoma. ( 29207829 )
2017
37
Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma. ( 28729769 )
2017
38
The role of computed tomography and magnetic resonance imaging in diagnosing clear cell ameloblastoma: A case report. ( 29344160 )
2017
39
Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis). ( 28942297 )
2017
40
BRAF-V600E expression correlates with ameloblastoma aggressiveness. ( 27681305 )
2017
41
Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells. ( 28699252 )
2017
42
Genetic study of the BRAF gene reveals a new variants and high frequency of the V600E mutation among Iranian ameloblastoma patients. ( 28650588 )
2017
43
Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma. ( 27671684 )
2017
44
Rare case of ameloblastoma with pulmonary metastases. ( 28944145 )
2017
45
Focal Adhesion Kinase Expression in Ameloblastoma: A Preliminary Observational Study. ( 28764292 )
2017
46
Peripheral Ameloblastoma: A Study of 18 Cases and Usage of Ber-EP4 Immunohistochemistry to Rule out a Diagnosis of Intraoral Basal Cell Carcinoma. ( 29247621 )
2017
47
A rare case report of an adenomatoid odontogenic tumor associated with odontoma in the maxilla. ( 28863377 )
2017
48
Unicystic ameloblastoma in conjunction with peripheral ameloblastoma: A unique case report presenting with diverse histological patterns. ( 28932038 )
2017
49
Suspected Lateral Periodontal Cyst Presenting Concurrently with Canine Acanthomatous Ameloblastoma in a 2-Year-Old Standard Poodle. ( 28639881 )
2017
50
Granular ameloblastoma: report of two cases with atypical cytological aspects. ( 29250680 )
2017

Variations for Ameloblastoma

Expression for Ameloblastoma

Search GEO for disease gene expression data for Ameloblastoma.

Pathways for Ameloblastoma

GO Terms for Ameloblastoma

Cellular components related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 BSG KRT14 KRT18 KRT8 PCNA SERPINA3
2 keratin filament GO:0045095 8.8 KRT14 KRT18 KRT8

Biological processes related to Ameloblastoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.72 KRT18 KRT8 TNFSF11
2 cornification GO:0070268 9.69 KRT14 KRT18 KRT8
3 positive regulation of smoothened signaling pathway GO:0045880 9.58 GLI1 SMO
4 response to cadmium ion GO:0046686 9.58 PCNA TERT
5 extracellular matrix disassembly GO:0022617 9.58 BSG MMP2 MMP20
6 renal system development GO:0072001 9.57 PTCH1 SMO
7 regulation of smoothened signaling pathway GO:0008589 9.56 GLI1 PTCH1
8 prostate gland development GO:0030850 9.54 GLI1 PTCH1
9 smoothened signaling pathway GO:0007224 9.54 GLI1 PTCH1 SMO
10 somite development GO:0061053 9.52 PTCH1 SMO
11 odontogenesis of dentin-containing tooth GO:0042475 9.5 AMBN BSG SMO
12 dorsal/ventral neural tube patterning GO:0021904 9.49 PTCH1 SMO
13 mammary gland epithelial cell differentiation GO:0060644 9.48 PTCH1 SMO
14 cellular response to cholesterol GO:0071397 9.46 PTCH1 SMO
15 hepatocyte apoptotic process GO:0097284 9.43 KRT18 KRT8
16 cerebellar cortex morphogenesis GO:0021696 9.26 GLI1 SMO
17 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.16 GLI1 SMO
18 dorsal/ventral pattern formation GO:0009953 9.13 GLI1 PTCH1 SMO
19 liver regeneration GO:0097421 8.8 GLI1 PCNA PTCH1

Molecular functions related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 AMBN BSG GLI1 KRT14 KRT18 KRT8
2 patched binding GO:0005113 9.16 PTCH1 SMO
3 tumor necrosis factor receptor superfamily binding GO:0032813 8.96 TNFSF10 TNFSF11

Sources for Ameloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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