MCID: AML029
MIFTS: 53

Ameloblastoma

Categories: Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ameloblastoma

MalaCards integrated aliases for Ameloblastoma:

Name: Ameloblastoma 12 54 60 56 45 15 74
Adenomatoid Odontogenic Tumor 54 17
Adenoameloblastoma 54 74
Aot 54

Characteristics:

Orphanet epidemiological data:

60
ameloblastoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare odontological diseases


External Ids:

Disease Ontology 12 DOID:0050894
MeSH 45 D000564
ICD10 via Orphanet 35 D16.4 D16.5
UMLS via Orphanet 75 C0002448
Orphanet 60 ORPHA314419

Summaries for Ameloblastoma

NIH Rare Diseases : 54 Ameloblastoma is a rare, noncancerous (benign) tumor that typically develops in the jaw near the molars. It originates in the cells that form the enamel that protects your teeth. The condition most often occurs in adults in their 30s and 40s, though it can occur at any age. In many cases, the first sign is painless swelling in the jaw. While it can be very aggressive, these tumors are rarely found outside of the jaw. Treatment is complete surgical removal of the affected tissue.

MalaCards based summary : Ameloblastoma, also known as adenomatoid odontogenic tumor, is related to calcifying epithelial odontogenic tumor and keratocystic odontogenic tumor. An important gene associated with Ameloblastoma is AMBN (Ameloblastin), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. The drugs Prednisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and lung, and related phenotypes are growth/size/body region and craniofacial

Disease Ontology : 12 A cell type benign neoplasm that has material basis in odontogenic epithelium.

Wikipedia : 77 Ameloblastoma (from the early English word amel, meaning enamel + the Greek word blastos, meaning germ)... more...

Related Diseases for Ameloblastoma

Diseases related to Ameloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 calcifying epithelial odontogenic tumor 32.4 AMBN KRT8 PTCH1
2 keratocystic odontogenic tumor 30.9 GLI1 PTCH1 SMO TNFSF11
3 basal cell carcinoma 30.4 GLI1 KRT8 PTCH1 SMO
4 papilloma 30.4 KRT14 KRT8 PCNA
5 odontoma 29.8 KRT14 KRT18 KRT8 PCNA
6 basaloid squamous cell carcinoma 29.7 KRT14 KRT8
7 breast cancer 27.3 BSG GLI1 KRT14 KRT18 KRT8 MMP2
8 bone ameloblastoma 12.1
9 schimmelpenning-feuerstein-mims syndrome 11.1
10 ameloblastic carcinoma 10.5
11 basal cell carcinoma, multiple 10.4 PTCH1 SMO
12 arteriovenous fistula 10.3 MMP2 PCNA
13 basal cell carcinoma 1 10.3
14 pigmented basal cell carcinoma 10.3 KRT14 PTCH1
15 squamous cell carcinoma 10.3
16 apocrine sweat gland neoplasm 10.2 KRT14 KRT8
17 nodular medulloblastoma 10.2 GLI1 PTCH1
18 fibroma 10.2
19 neurenteric cyst 10.2 KRT18 KRT8
20 proliferating trichilemmal cyst 10.2 KRT18 KRT8
21 cutaneous adenocystic carcinoma 10.2 KRT18 KRT8
22 nasal cavity squamous cell carcinoma 10.2 KRT8 MMP2
23 amelogenesis imperfecta, type iiia 10.2 AMBN MMP20
24 basal cell nevus syndrome 10.1 GLI1 PTCH1 SMO
25 cryptogenic cirrhosis 10.1 KRT18 KRT8
26 benign meningioma 10.1 PCNA TERT
27 brooke-spiegler syndrome 10.1 KRT14 KRT8 PTCH1
28 hypocalcified amelogenesis imperfecta 10.1 AMBN MMP20
29 mucinous tubular and spindle renal cell carcinoma 10.1 KRT18 KRT8
30 dental fluorosis 10.1 AMBN MMP20
31 papillary ependymoma 10.1 KRT18 KRT8
32 lymphoepithelioma-like carcinoma 10.1 KRT18 KRT8
33 neutrophil migration 10.1
34 vitreoretinopathy, neovascular inflammatory 10.1
35 isolated optic neuritis 10.1
36 ossifying fibroma 10.1
37 gingival overgrowth 10.1
38 lung giant cell carcinoma 10.1 KRT18 MMP2
39 pregnancy adenoma 10.0 KRT14 KRT8
40 teeth hard tissue disease 10.0 AMBN MMP20 TNFSF11
41 oncocytoma 10.0
42 hemangioma 10.0
43 cystadenoma 10.0
44 craniopharyngioma 10.0
45 cervical clear cell adenocarcinoma 10.0 KRT14 KRT18 KRT8
46 intraneural perineurioma 10.0 KRT14 KRT18 KRT8
47 primary cutaneous amyloidosis 10.0 KRT14 KRT18 KRT8
48 sweat gland cancer 10.0 KRT14 KRT18 KRT8
49 gastric squamous cell carcinoma 10.0 GLI1 SERPINA3
50 lipoadenoma 10.0 KRT14 SERPINA3

Graphical network of the top 20 diseases related to Ameloblastoma:



Diseases related to Ameloblastoma

Symptoms & Phenotypes for Ameloblastoma

MGI Mouse Phenotypes related to Ameloblastoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 AMBN BSG GLI1 KRT14 KRT18 KRT8
2 craniofacial MP:0005382 10.1 AMBN GLI1 KRT14 MMP2 MMP20 PTCH1
3 mortality/aging MP:0010768 10.1 BSG GLI1 KRT14 KRT18 KRT8 MMP2
4 endocrine/exocrine gland MP:0005379 10.06 BSG GLI1 KRT14 PCNA PTCH1 TERT
5 hematopoietic system MP:0005397 10.06 BSG KRT14 KRT8 MMP2 PCNA PTCH1
6 immune system MP:0005387 10.02 BSG KRT14 KRT8 MMP2 PCNA PTCH1
7 digestive/alimentary MP:0005381 9.95 GLI1 KRT14 KRT8 PTCH1 SMO TERT
8 neoplasm MP:0002006 9.86 AMBN GLI1 KRT14 MMP2 PTCH1 TERT
9 reproductive system MP:0005389 9.76 BSG GLI1 KRT14 KRT8 PCNA PTCH1
10 respiratory system MP:0005388 9.56 BSG GLI1 KRT14 MMP2 PTCH1 SMO
11 skeleton MP:0005390 9.17 AMBN MMP2 PTCH1 SMO TERT TNFSF10

Drugs & Therapeutics for Ameloblastoma

Drugs for Ameloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Not Applicable
5 Hydrocortisone-17-butyrate Phase 4
6 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
7 Anesthetics Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 glucocorticoids Phase 4,Phase 1
10 Anti-Inflammatory Agents Phase 4,Phase 1
11 Hydrocortisone hemisuccinate Phase 4
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
13 Hormones Phase 4,Phase 3,Phase 2,Phase 1
14
Exenatide Approved, Investigational Phase 3,Phase 2 141758-74-9 15991534
15
Glucagon Approved Phase 3 16941-32-5
16
Diazoxide Approved Phase 3,Phase 2 364-98-7 3019
17 Hypoglycemic Agents Phase 3,Phase 2
18 Anti-Obesity Agents Phase 3,Phase 2
19 Incretins Phase 3,Phase 2
20 Glucagon-Like Peptide 1 Phase 3
21 Antihypertensive Agents Phase 3,Phase 2
22 Vasodilator Agents Phase 3,Phase 2
23
Peginterferon alfa-2b Approved Phase 2 215647-85-1, 99210-65-8
24
Metformin Approved Phase 2 657-24-9 14219 4091
25
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
26
Trametinib Approved Phase 2 871700-17-3 11707110
27
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
28
Vemurafenib Approved Phase 2 918504-65-1 23252090 42611257
29
Oxytocin Approved, Vet_approved Phase 2 50-56-6 53477758 439302
30
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
31
Memantine Approved, Investigational Phase 2 19982-08-2 4054
32
Methionine Approved, Nutraceutical Phase 2 63-68-3 6137
33 Antiviral Agents Phase 2
34 Immunologic Factors Phase 2,Phase 1
35 Anti-Infective Agents Phase 2
36 Interferon-alpha Phase 2
37 interferons Phase 2
38 insulin Phase 2
39 Insulin, Globin Zinc Phase 2
40 Angiogenesis Modulating Agents Phase 2,Phase 1
41 Angiogenesis Inhibitors Phase 2,Phase 1
42 CKD732 Phase 2
43 topoisomerase I inhibitors Phase 2
44 Topoisomerase Inhibitors Phase 2
45 Protein Kinase Inhibitors Phase 2
46 Oxytocics Phase 2
47 Neurotransmitter Agents Phase 2
48 Excitatory Amino Acids Phase 2
49 Antiparkinson Agents Phase 2
50 Excitatory Amino Acid Antagonists Phase 2

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
2 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
3 Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy Completed NCT02860923 Phase 3 Exenatide;Placebo
4 Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions Completed NCT00306683 Phase 3 DIAZOXIDE
5 Peginterferon Alfa-2b in Treating Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery Completed NCT01964300 Phase 2
6 Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy Completed NCT00892073 Phase 2 Diazoxide;Metformin
7 An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury Completed NCT02063295 Phase 2 ZGN-440 sterile diluent;ZGN-440 for injectable suspension
8 Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor Completed NCT01484873 Phase 2 Exenatide
9 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
10 Dabrafenib and Trametinib in Treating Patients With BRAF Mutated Ameloblastoma Recruiting NCT02367859 Phase 2 Dabrafenib;Trametinib
11 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib
12 A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection Recruiting NCT02792582 Phase 2
13 Intranasal Oxytocin in Hypothalamic Obesity Recruiting NCT02849743 Phase 2 Syntocinon;Placebo (for Syntocinon)
14 Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors Recruiting NCT03194906 Phase 2 Memantine
15 Methionine PET/CT Studies In Patients With Cancer Recruiting NCT00840047 Phase 2 Methionine
16 Management of Pediatric Craniopharyngioma by a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma) Active, not recruiting NCT02842723 Phase 2
17 A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection Active, not recruiting NCT01419067 Phase 2 ^1^8F-fluorodeoxyglucose;^1^1C-methionine
18 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
19 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
20 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
21 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
22 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
23 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
24 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia Completed NCT00053963 Phase 1 romidepsin
27 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
28 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
29 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
30 Neuromodulation for Hypothalamic Obesity Withdrawn NCT03708913 Phase 1
31 Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma Unknown status NCT00949156
32 Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients Completed NCT03330080
33 Social Participation After Childhood Craniopharyngioma Completed NCT03139526
34 1.5T Intraoperative MR Imaging in Craniopharyngiomas Completed NCT01206543 Not Applicable
35 Weight Gain in Surgically Treated Adult-onset Craniopharyngioma Completed NCT01968603
36 Sleep Wake and Melatonin Pattern in Craniopharyngioma Completed NCT01881854
37 Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma Completed NCT00258453 Not Applicable
38 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Completed NCT00919750
39 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
40 Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906
41 Prospective Study of Children and Adolescents With Craniopharyngioma Recruiting NCT01272622 Not Applicable
42 Molecular-Guided Therapy for Childhood Cancer Active, not recruiting NCT02162732 Not Applicable
43 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Ameloblastoma

Cochrane evidence based reviews: ameloblastoma

Genetic Tests for Ameloblastoma

Anatomical Context for Ameloblastoma

MalaCards organs/tissues related to Ameloblastoma:

42
Bone, Brain, Lung, Lymph Node, Spinal Cord, Pituitary, T Cells

Publications for Ameloblastoma

Articles related to Ameloblastoma:

(show top 50) (show all 1788)
# Title Authors Year
1
Ameloblastic carcinoma ex ameloblastoma of the maxilla. ( 30967726 )
2019
2
Conservative Treatment of Ameloblastoma in a Pediatric Patient: A Case Report. ( 30902604 )
2019
3
Mutational Signatures in Mandibular Ameloblastoma Correlate with Smoking. ( 30917298 )
2019
4
An Ameloblastoma in the Middle Ear. ( 30924778 )
2019
5
Recurrent unicystic maxillary ameloblastoma presenting as unilateral proptosis. ( 30930671 )
2019
6
Desmoplastic ameloblastoma of the jaw: CT and MR imaging findings. ( 30941567 )
2019
7
Hybrid ameloblastoma: a mystified histopathological entity. ( 30975786 )
2019
8
Upregulation of interleukin-8 and activin A induces osteoclastogenesis in ameloblastoma. ( 31017256 )
2019
9
Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma. ( 31041834 )
2019
10
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma. ( 31078505 )
2019
11
Risk factors for recurrence of ameloblastoma: a long-term follow-up retrospective study. ( 31084977 )
2019
12
Misdiagnosis of ameloblastoma in a patient with clear cell odontogenic carcinoma: a case report. ( 31106140 )
2019
13
Expression of p63 in tooth germ, dentigerous cyst and ameloblastoma. ( 31110415 )
2019
14
Sinonasal Ameloblastoma. ( 29846904 )
2019
15
The Mutational Profile of Unicystic Ameloblastoma. ( 30216733 )
2019
16
MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma. ( 30225187 )
2019
17
Yes-associated protein (YAP) molecule expression in odontogenic epithelium of ameloblastoma. ( 30302608 )
2019
18
Mandibular Regeneration With Autologous Human Bone Marrow Derived Mesenchymal Stem Cells to Treat Unicystic Ameloblastoma: A Clinical Report. ( 30444778 )
2019
19
Distraction Osteogenesis of Fibula Graft for Mandibular Reconstruction Following Ameloblastoma Ablation. ( 30480630 )
2019
20
Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: A review. ( 30489659 )
2019
21
Genetic alteration of Exon 5 of the PTEN gene in Indian patients with ameloblastoma. ( 30598407 )
2019
22
Global incidence and profile of ameloblastoma: a systematic review and meta-analysis. ( 30614154 )
2019
23
Surgical management of ameloblastoma. Review of literature. ( 30697397 )
2019
24
Assessment of fragile histidine triad expression in ameloblastoma, odontogenic keratocyst and dentigerous cyst. ( 30706851 )
2019
25
Unicystic Ameloblastoma in a Child Treated with a Combination of Conservative Surgery and Orthodontic Treatment: A Case Report. ( 30730804 )
2019
26
The importance of BRAF-V600E mutation to ameloblastoma metabolism. ( 30739334 )
2019
27
Recurrent peripheral ameloblastoma in an elderly patient: A case report. ( 30779401 )
2019
28
Reconstruction of Deep Circumflex Iliac Artery Free Flap for Multiple Recurrent Ameloblastoma in Mandible. ( 30789382 )
2019
29
RBM10 truncation in astroblastoma in a patient with history of mandibular ameloblastoma: A case report. ( 30803556 )
2019
30
Cell proliferation proteins and aggressiveness of histological variants of ameloblastoma and keratocystic odontogenic tumor. ( 30806083 )
2019
31
Expression of keratin 15 in dentigerous cyst, odontogenic keratocyst and ameloblastoma. ( 30847177 )
2019
32
Negligence or tumor aggressiveness: A case report of recurrent ameloblastoma. ( 30886719 )
2019
33
High prevalence of BRAF V600E mutations in Korean patients with ameloblastoma: Clinicopathological significance and correlation with epithelial-mesenchymal transition. ( 30889301 )
2019
34
Calcifying cystic odontogenic tumor associated with ameloblastoma - A rare histological variant. ( 30900676 )
2019
35
Peripheral adenomatoid odontogenic tumor in a cloak of an epulis: report of a rare case. ( 31077195 )
2019
36
Adenomatoid odontogenic tumor: An updated analysis of the cases reported in the literature. ( 30256456 )
2019
37
Recurrence of adenomatoid odontogenic tumor. ( 30403429 )
2019
38
KRAS mutations drive adenomatoid odontogenic tumor and are independent of clinicopathological features. ( 30643167 )
2019
39
Surgical Management of Extrafollicular Variant of Adenomatoid Odontogenic Tumor in the Maxillary Posterior Region. ( 30838139 )
2019
40
Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma. ( 30596059 )
2018
41
Prenatal diagnosis of unicystic ameloblastoma. ( 29108911 )
2018
42
Peripheral Ameloblastoma: A Study of 18 Cases and Usage of Ber-EP4 Immunohistochemistry to Rule out a Diagnosis of Intraoral Basal Cell Carcinoma. ( 29247621 )
2018
43
The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study. ( 29274152 )
2018
44
Treatment of Mandibular Ameloblastoma Involving the Mandibular Condyle: Resection and Concomitant Reconstruction With a Custom Hybrid Total Joint Prosthesis and Iliac Bone Graft. ( 29381612 )
2018
45
Evaluation of Midkine Expression in Dentigerous Cysts, Odontogenic Keratocysts and Different Types of Ameloblastoma. ( 29383694 )
2018
46
Expression profile of polycomb group proteins in odontogenic keratocyst and ameloblastoma. ( 29415809 )
2018
47
Rate of Relapse After Enucleation of Solid/Multicystic Ameloblastoma Followed by Piezoelectric or Conventional Peripheral Ostectomy. ( 29419594 )
2018
48
Expression of TP53 and IL-1α in unicystic ameloblastoma predicts the efficacy of marsupialization treatment. ( 29419674 )
2018
49
Oral and masticatory rehabilitation using osseointegrated dental implants after resective treatment of multicystic ameloblastoma in the lower jaw with a fibula graft. ( 29442096 )
2018
50
Prognostic importance of FGF2 and FGFR1 expression for patients affected by ameloblastoma. ( 29453876 )
2018

Variations for Ameloblastoma

Expression for Ameloblastoma

Search GEO for disease gene expression data for Ameloblastoma.

Pathways for Ameloblastoma

GO Terms for Ameloblastoma

Cellular components related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 BSG KRT14 KRT18 KRT8 PCNA SERPINA3
2 keratin filament GO:0045095 9.33 KRT14 KRT18 KRT8
3 cell periphery GO:0071944 8.8 KRT14 KRT18 KRT8

Biological processes related to Ameloblastoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.71 KRT14 KRT18 KRT8
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.61 KRT18 KRT8 TNFSF11
3 positive regulation of DNA replication GO:0045740 9.59 GLI1 PCNA
4 response to cadmium ion GO:0046686 9.58 PCNA TERT
5 regulation of smoothened signaling pathway GO:0008589 9.58 GLI1 PTCH1
6 smoothened signaling pathway GO:0007224 9.58 GLI1 PTCH1 SMO
7 renal system development GO:0072001 9.57 PTCH1 SMO
8 cellular response to cholesterol GO:0071397 9.56 PTCH1 SMO
9 somite development GO:0061053 9.55 PTCH1 SMO
10 extracellular matrix disassembly GO:0022617 9.54 BSG MMP2 MMP20
11 prostate gland development GO:0030850 9.52 GLI1 PTCH1
12 dorsal/ventral neural tube patterning GO:0021904 9.51 PTCH1 SMO
13 odontogenesis of dentin-containing tooth GO:0042475 9.5 AMBN BSG SMO
14 mammary gland epithelial cell differentiation GO:0060644 9.49 PTCH1 SMO
15 commissural neuron axon guidance GO:0071679 9.48 PTCH1 SMO
16 hepatocyte apoptotic process GO:0097284 9.46 KRT18 KRT8
17 cerebellar cortex morphogenesis GO:0021696 9.26 GLI1 SMO
18 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.16 GLI1 SMO
19 dorsal/ventral pattern formation GO:0009953 9.13 GLI1 PTCH1 SMO
20 liver regeneration GO:0097421 8.8 GLI1 PCNA PTCH1

Molecular functions related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 AMBN BSG GLI1 KRT14 KRT18 KRT8
2 patched binding GO:0005113 9.16 PTCH1 SMO
3 tumor necrosis factor receptor superfamily binding GO:0032813 8.96 TNFSF10 TNFSF11

Sources for Ameloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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