AOT
MCID: AML029
MIFTS: 49

Ameloblastoma (AOT)

Categories: Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Ameloblastoma

MalaCards integrated aliases for Ameloblastoma:

Name: Ameloblastoma 12 53 59 55 44 15 73
Adenoameloblastoma 53 73
Adenomatoid Odontogenic Tumor 53
Aot 53

Characteristics:

Orphanet epidemiological data:

59
ameloblastoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare odontological diseases


External Ids:

Disease Ontology 12 DOID:0050894
MeSH 44 D000564
Orphanet 59 ORPHA314419
ICD10 via Orphanet 34 D16.5 D16.4
UMLS via Orphanet 74 C0002448

Summaries for Ameloblastoma

NIH Rare Diseases : 53 Ameloblastoma is a rare, noncancerous (benign) tumor that typically develops in the jaw near the molars. It originates in the cells that form the enamel that protects your teeth. The condition most often occurs in adults in their 30s and 40s, though it can occur at any age. In many cases, the first sign is painless swelling in the jaw. While it can be very aggressive, these tumors are rarely found outside of the jaw. Treatment is complete surgical removal of the affected tissue.

MalaCards based summary : Ameloblastoma, also known as adenoameloblastoma, is related to calcifying epithelial odontogenic tumor and keratocystic odontogenic tumor. An important gene associated with Ameloblastoma is AMBN (Ameloblastin), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and lymph node, and related phenotypes are growth/size/body region and craniofacial

Disease Ontology : 12 A cell type benign neoplasm that has material basis in odontogenic epithelium.

Wikipedia : 76 Ameloblastoma (from the early English word amel, meaning enamel + the Greek word blastos, meaning germ)... more...

Related Diseases for Ameloblastoma

Diseases related to Ameloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 calcifying epithelial odontogenic tumor 32.3 AMBN KRT8 PTCH1
2 keratocystic odontogenic tumor 30.8 GLI1 PTCH1 SMO TNFSF11
3 basal cell carcinoma 30.2 GLI1 KRT14 KRT8 PTCH1 SMO
4 papilloma 30.0 KRT14 KRT8 PCNA
5 odontoma 29.8 KRT14 KRT18 KRT8 PCNA
6 basaloid squamous cell carcinoma 29.7 KRT14 KRT8
7 bone ameloblastoma 12.1
8 schimmelpenning-feuerstein-mims syndrome 11.1
9 ameloblastic carcinoma 10.4
10 basal cell carcinoma 1 10.3
11 basal cell carcinoma, multiple 10.2 PTCH1 SMO
12 squamous cell carcinoma 10.2
13 arteriovenous fistula 10.2 MMP2 PCNA
14 pigmented basal cell carcinoma 10.2 KRT14 PTCH1
15 apocrine sweat gland neoplasm 10.2 KRT14 KRT8
16 nodular medulloblastoma 10.2 GLI1 PTCH1
17 neurenteric cyst 10.1 KRT18 KRT8
18 proliferating trichilemmal cyst 10.1 KRT18 KRT8
19 cutaneous adenocystic carcinoma 10.1 KRT18 KRT8
20 nasal cavity squamous cell carcinoma 10.1 KRT8 MMP2
21 amelogenesis imperfecta, type iiia 10.1 AMBN MMP20
22 cryptogenic cirrhosis 10.1 KRT18 KRT8
23 basal cell nevus syndrome 10.1 GLI1 PTCH1 SMO
24 vitreoretinopathy, neovascular inflammatory 10.1
25 hypocalcified amelogenesis imperfecta 10.1 AMBN MMP20
26 benign meningioma 10.1 PCNA TERT
27 brooke-spiegler syndrome 10.1 KRT14 KRT8 PTCH1
28 mucinous tubular and spindle renal cell carcinoma 10.1 KRT18 KRT8
29 dental fluorosis 10.1 AMBN MMP20
30 papillary ependymoma 10.1 KRT18 KRT8
31 root resorption 10.1
32 ossifying fibroma 10.1
33 gingival overgrowth 10.1
34 lymphoepithelioma-like carcinoma 10.1 KRT18 KRT8
35 lung giant cell carcinoma 10.0 KRT18 MMP2
36 oncocytoma 10.0
37 pregnancy adenoma 10.0 KRT14 KRT8
38 teeth hard tissue disease 10.0 AMBN MMP20 TNFSF11
39 cervical clear cell adenocarcinoma 10.0 KRT14 KRT18 KRT8
40 intraneural perineurioma 10.0 KRT14 KRT18 KRT8
41 primary cutaneous amyloidosis 10.0 KRT14 KRT18 KRT8
42 grade iii astrocytoma 10.0 BSG MMP2 PCNA
43 sweat gland cancer 10.0 KRT14 KRT18 KRT8
44 erdheim-chester disease 10.0 SERPINA3 TNFSF11
45 nevus, epidermal 10.0
46 hemangioma 10.0
47 adenoid cystic carcinoma 10.0
48 craniopharyngioma 10.0
49 epulis 10.0
50 adenoma 10.0

Graphical network of the top 20 diseases related to Ameloblastoma:



Diseases related to Ameloblastoma

Symptoms & Phenotypes for Ameloblastoma

MGI Mouse Phenotypes related to Ameloblastoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 AMBN BSG GLI1 KRT14 KRT18 KRT8
2 craniofacial MP:0005382 10.1 AMBN GLI1 KRT14 MMP2 MMP20 PTCH1
3 mortality/aging MP:0010768 10.1 BSG GLI1 KRT14 KRT18 KRT8 MMP2
4 endocrine/exocrine gland MP:0005379 10.06 BSG GLI1 KRT14 PCNA PTCH1 TERT
5 hematopoietic system MP:0005397 10.06 BSG KRT14 KRT8 MMP2 PCNA PTCH1
6 immune system MP:0005387 10.02 BSG KRT14 KRT8 MMP2 PCNA PTCH1
7 digestive/alimentary MP:0005381 9.95 GLI1 KRT14 KRT8 PTCH1 SMO TERT
8 neoplasm MP:0002006 9.86 AMBN GLI1 KRT14 MMP2 PTCH1 TERT
9 reproductive system MP:0005389 9.76 BSG GLI1 KRT14 KRT8 PCNA PTCH1
10 respiratory system MP:0005388 9.56 BSG GLI1 KRT14 MMP2 PTCH1 SMO
11 skeleton MP:0005390 9.17 AMBN MMP2 PTCH1 SMO TERT TNFSF10

Drugs & Therapeutics for Ameloblastoma

Drugs for Ameloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4 Hormones Phase 4,Phase 3,Phase 2,Phase 1
5 Anti-Inflammatory Agents Phase 4,Phase 1
6 Hydrocortisone 17-butyrate 21-propionate Phase 4
7 glucocorticoids Phase 4,Phase 1
8 Hydrocortisone-17-butyrate Phase 4
9 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
10 Anesthetics Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
12 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Not Applicable
13 Cortisol succinate Phase 4
14
Exenatide Approved, Investigational Phase 3,Phase 2 141758-74-9 15991534
15
Diazoxide Approved Phase 3,Phase 2 364-98-7 3019
16 Incretins Phase 3,Phase 2
17 Hypoglycemic Agents Phase 3,Phase 2
18 glucagon Phase 3
19 Glucagon-Like Peptide 1 Phase 3
20 Antihypertensive Agents Phase 3,Phase 2
21 Vasodilator Agents Phase 3,Phase 2
22
Metformin Approved Phase 2 657-24-9 14219 4091
23
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
24
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
25
Trametinib Approved Phase 2 871700-17-3 11707110
26
Vemurafenib Approved Phase 2 918504-65-1 23252090 42611257
27
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
28
Memantine Approved, Investigational Phase 2 19982-08-2 4054
29
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
30
Peginterferon alfa-2b Approved Phase 2 99210-65-8, 215647-85-1
31
Methionine Approved, Nutraceutical Phase 2 63-68-3 6137
32
Camptothecin Experimental Phase 2 7689-03-4
33 Insulin, Globin Zinc Phase 2
34 insulin Phase 2
35 Antineoplastic Agents, Phytogenic Phase 2
36 topoisomerase I inhibitors Phase 2
37 Topoisomerase Inhibitors Phase 2
38 Anti-Infective Agents Phase 2,Phase 1
39 Immunologic Factors Phase 2,Phase 1
40 Protein Kinase Inhibitors Phase 2
41 Oxytocics Phase 2
42 Dopamine Agents Phase 2
43 Excitatory Amino Acids Phase 2
44 Excitatory Amino Acid Antagonists Phase 2
45 Antiparkinson Agents Phase 2
46 Neurotransmitter Agents Phase 2
47 interferons Phase 2
48 Antiviral Agents Phase 2
49 Interferon-alpha Phase 2
50 Fluorodeoxyglucose F18 Phase 2

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
2 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
3 Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy Completed NCT02860923 Phase 3 Exenatide;Placebo
4 Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions Completed NCT00306683 Phase 3 DIAZOXIDE
5 Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy Completed NCT00892073 Phase 2 Diazoxide;Metformin
6 An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury Completed NCT02063295 Phase 2 ZGN-440 sterile diluent;ZGN-440 for injectable suspension
7 Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor Completed NCT01484873 Phase 2 Exenatide
8 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
9 Dabrafenib and Trametinib in Treating Patients With BRAF Mutated Ameloblastoma Recruiting NCT02367859 Phase 2 Dabrafenib;Trametinib
10 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib
11 A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection Recruiting NCT02792582 Phase 2
12 Intranasal Oxytocin in Hypothalamic Obesity Recruiting NCT02849743 Phase 2 Syntocinon;Placebo (for Syntocinon)
13 Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors Recruiting NCT03194906 Phase 2 Memantine
14 Methionine PET/CT Studies In Patients With Cancer Recruiting NCT00840047 Phase 2 Methionine
15 Management of Pediatric Craniopharyngioma by a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma) Active, not recruiting NCT02842723 Phase 2
16 Peginterferon Alfa-2b in Treating Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery Active, not recruiting NCT01964300 Phase 2
17 A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection Active, not recruiting NCT01419067 Phase 2 ^1^8F-fluorodeoxyglucose;^1^1C-methionine
18 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
19 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
20 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
21 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
22 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
23 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
24 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia Completed NCT00053963 Phase 1 romidepsin
27 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
28 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
29 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
30 Neuromodulation for Hypothalamic Obesity Withdrawn NCT03708913 Phase 1
31 Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma Unknown status NCT00949156
32 Social Participation After Childhood Craniopharyngioma Completed NCT03139526
33 1.5T Intraoperative MR Imaging in Craniopharyngiomas Completed NCT01206543 Not Applicable
34 Weight Gain in Surgically Treated Adult-onset Craniopharyngioma Completed NCT01968603
35 Sleep Wake and Melatonin Pattern in Craniopharyngioma Completed NCT01881854
36 Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma Completed NCT00258453 Not Applicable
37 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Completed NCT00919750
38 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
39 Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy Recruiting NCT03610906
40 Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients Recruiting NCT03330080
41 Prospective Study of Children and Adolescents With Craniopharyngioma Recruiting NCT01272622 Not Applicable
42 Molecular-Guided Therapy for Childhood Cancer Active, not recruiting NCT02162732 Not Applicable
43 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Ameloblastoma

Cochrane evidence based reviews: ameloblastoma

Genetic Tests for Ameloblastoma

Anatomical Context for Ameloblastoma

MalaCards organs/tissues related to Ameloblastoma:

41
Bone, Lung, Lymph Node, Brain, Testes, Breast, Prostate

Publications for Ameloblastoma

Articles related to Ameloblastoma:

(show top 50) (show all 1063)
# Title Authors Year
1
MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma. ( 30225187 )
2019
2
Ameloblastoma with adenoid features: A series of eight cases. ( 29799420 )
2018
3
Fine-needle aspiration cytology as a useful diagnostic adjunct in the management of ameloblastoma: A report of four cases. ( 29937671 )
2018
4
Evaluation of Midkine Expression in Dentigerous Cysts, Odontogenic Keratocysts and Different Types of Ameloblastoma. ( 29383694 )
2018
5
Marsupialization of mandibular cystic ameloblastoma: Retrospective study of 7 years. ( 29756338 )
2018
6
Expression profile of polycomb group proteins in odontogenic keratocyst and ameloblastoma. ( 29415809 )
2018
7
Bilocular unicystic ameloblastoma of the mandible in a 9 yr old child - A diagnostic and management dilemma. ( 29942110 )
2018
8
Fascin Expression in Ameloblastoma, Odontogenic Keratocyst and Dentigerous Cyst. ( 29926463 )
2018
9
Elevated hydrostatic pressure promotes ameloblastoma cell invasion through up-regulation of MMP-2 and MMP-9 expression via Wnt/I^-catenin signalling. ( 29964338 )
2018
10
Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography. ( 29791200 )
2018
11
Recurrent Ameloblastoma: A Surgical Challenge. ( 29682361 )
2018
12
Oral peripheral ameloblastoma: A retrospective series study of 25 cases. ( 29680843 )
2018
13
Expression of TP53 and IL-1I+ in unicystic ameloblastoma predicts the efficacy of marsupialization treatment. ( 29419674 )
2018
14
Prenatal diagnosis of unicystic ameloblastoma. ( 29108911 )
2018
15
Comparative Study of the Minichromosome Maintenance Proteins Complex (MCM 4/5/6) in Ameloblastoma and Unicystic Ameloblastoma. ( 29845895 )
2018
16
Granular cell type of ameloblastoma. ( 29922343 )
2018
17
Expression of ameloblastin in the human tooth germ and ameloblastoma. ( 29974993 )
2018
18
Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor. ( 29657523 )
2018
19
Unicystic ameloblastoma: Analysis of 370 cases in a single center in Sri Lanka. ( 29858565 )
2018
20
Rate of Relapse After Enucleation of Solid/Multicystic Ameloblastoma Followed by Piezoelectric or Conventional Peripheral Ostectomy. ( 29419594 )
2018
21
Sinonasal Ameloblastoma. ( 29846904 )
2018
22
Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report. ( 29974411 )
2018
23
Brain ameloblastoma: metastasis or local extension case report and physipathological reflexion. ( 29747056 )
2018
24
Oral and masticatory rehabilitation using osseointegrated dental implants after resective treatment of multicystic ameloblastoma in the lower jaw with a fibula graft. ( 29442096 )
2018
25
Treatment of Mandibular Ameloblastoma Involving the Mandibular Condyle: Resection and Concomitant Reconstruction With a Custom Hybrid Total Joint Prosthesis and Iliac Bone Graft. ( 29381612 )
2018
26
The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study. ( 29274152 )
2018
27
Long-term outcome of patients with or without osseointegrated implants after resection of mandibular ameloblastoma and reconstruction with vascularized bone graft: Functional assessment and quality of life. ( 29656899 )
2018
28
Expression of proteoglycans in two types of ameloblastoma: novel Immunohistochemical findings. ( 29921372 )
2018
29
Conservative surgical treatment for ameloblastoma: a report of three cases. ( 30402417 )
2018
30
Ameloblastoma: a retrospective single institute study of 34 subjects. ( 30404552 )
2018
31
Acanthomatous Ameloblastoma of Mandible in a Paediatric Patient. ( 30420932 )
2018
32
Mandibular Regeneration With Autologous Human Bone Marrow Derived Mesenchymal Stem Cells to Treat Unicystic Ameloblastoma: a Clinical Report. ( 30444778 )
2018
33
Enhanced basal autophagy supports ameloblastoma-derived cell survival and reactivation. ( 30465934 )
2018
34
Basal cell ameloblastoma: a rare entity expressed in a middle aged female. ( 30476386 )
2018
35
Distraction Osteogenesis of Fibula Graft for Mandibular Reconstruction Following Ameloblastoma Ablation. ( 30480630 )
2018
36
Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: A review. ( 30489659 )
2018
37
Ameloblastoma incidentally detected in cone-beam computed tomography sialography: A case report and review of the literature. ( 30497576 )
2018
38
Ameloblastoma: Management and Outcome. ( 30546984 )
2018
39
Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis. ( 30548549 )
2018
40
Ameloblastoma: current etiopathological concepts and management. ( 28142213 )
2018
41
Rare case of giant unicystic ameloblastoma: Luminal variant. ( 28187692 )
2018
42
Prognostic importance of FGF2 and FGFR1 expression for patients affected by ameloblastoma. ( 29453876 )
2018
43
Partial maxillectomy for ameloblastoma of the maxilla with infratemporal fossa involvement: A combined endoscopic endonasal and transoral approach. ( 29475080 )
2018
44
Ameloblastoma-Clinical, radiological, and therapeutic findings. ( 29480593 )
2018
45
Ameloblastoma arising in the wall of dentigerous cyst: Report of a rare entity. ( 29491596 )
2018
46
Hemangiomatous ameloblastoma: Case report with a brief review. ( 29491600 )
2018
47
COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma. ( 29559247 )
2018
48
Bronchoscopically Treated Endobronchial Ameloblastoma With Rapid Local Recurrence. ( 29561396 )
2018
49
Orbital invasion of ameloblastoma: A systematic review apropos of a rare entity. ( 29564405 )
2018
50
EGFR is not amplified in ameloblastoma. ( 29602688 )
2018

Variations for Ameloblastoma

Expression for Ameloblastoma

Search GEO for disease gene expression data for Ameloblastoma.

Pathways for Ameloblastoma

GO Terms for Ameloblastoma

Cellular components related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 BSG KRT14 KRT18 KRT8 PCNA SERPINA3
2 keratin filament GO:0045095 9.33 KRT14 KRT18 KRT8
3 cell periphery GO:0071944 8.8 KRT14 KRT18 KRT8

Biological processes related to Ameloblastoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.71 KRT14 KRT18 KRT8
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.61 KRT18 KRT8 TNFSF11
3 positive regulation of DNA replication GO:0045740 9.59 GLI1 PCNA
4 response to cadmium ion GO:0046686 9.58 PCNA TERT
5 regulation of smoothened signaling pathway GO:0008589 9.58 GLI1 PTCH1
6 smoothened signaling pathway GO:0007224 9.58 GLI1 PTCH1 SMO
7 renal system development GO:0072001 9.57 PTCH1 SMO
8 cellular response to cholesterol GO:0071397 9.56 PTCH1 SMO
9 somite development GO:0061053 9.55 PTCH1 SMO
10 extracellular matrix disassembly GO:0022617 9.54 BSG MMP2 MMP20
11 prostate gland development GO:0030850 9.52 GLI1 PTCH1
12 dorsal/ventral neural tube patterning GO:0021904 9.51 PTCH1 SMO
13 odontogenesis of dentin-containing tooth GO:0042475 9.5 AMBN BSG SMO
14 mammary gland epithelial cell differentiation GO:0060644 9.49 PTCH1 SMO
15 commissural neuron axon guidance GO:0071679 9.48 PTCH1 SMO
16 hepatocyte apoptotic process GO:0097284 9.46 KRT18 KRT8
17 cerebellar cortex morphogenesis GO:0021696 9.26 GLI1 SMO
18 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.16 GLI1 SMO
19 dorsal/ventral pattern formation GO:0009953 9.13 GLI1 PTCH1 SMO
20 liver regeneration GO:0097421 8.8 GLI1 PCNA PTCH1

Molecular functions related to Ameloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 AMBN BSG GLI1 KRT14 KRT18 KRT8
2 patched binding GO:0005113 9.16 PTCH1 SMO
3 tumor necrosis factor receptor superfamily binding GO:0032813 8.96 TNFSF10 TNFSF11

Sources for Ameloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
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49 NCI
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54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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