Aliases & Classifications for Amenorrhea

MalaCards integrated aliases for Amenorrhea:

Name: Amenorrhea 12 77 6 45 15 74
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD9CM 36 626.0
MeSH 45 D000568
NCIt 51 C61443
SNOMED-CT 69 14302001
ICD10 34 N91.2
UMLS 74 C0002453

Summaries for Amenorrhea

Disease Ontology : 12 A female reproductive system disease that is characterized by the absence of menstruation.

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to hypogonadotropic hypogonadism 23 without anosmia and pituitary adenoma, prolactin-secreting, and has symptoms including menometrorrhagia and ovulation bleeding. An important gene associated with Amenorrhea is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide ligand-binding receptors and DAG and IP3 signaling. The drugs Sodium Citrate and Metformin have been mentioned in the context of this disorder. Affiliated tissues include breast, pituitary and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 77 Amenorrhea is the absence of a menstrual period in a woman of reproductive age. Physiological states of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 31.8 FSHR GNRH1 LHB
2 pituitary adenoma, prolactin-secreting 31.5 POMC PRL TRH
3 anorexia nervosa 31.5 CRH LEP POMC PRL
4 polycystic ovary syndrome 30.9 FSHR GDF9 GNRH1 LEP PRL SHBG
5 premature ovarian failure 1 30.5 BMP15 FSHR GDF9 GNRH1 NOBOX NR5A1
6 gonadal dysgenesis 30.4 BMP15 FSHR NR5A1
7 hypogonadotropism 30.3 GNRH1 PRL
8 endometriosis 30.1 GNRH1 NR5A1 WNT4
9 diabetes insipidus 30.0 CRH POMC PRL
10 craniopharyngioma 30.0 GNRH1 PRL TRH
11 hypogonadism 30.0 FSHB GNRH1 LHB LHCGR
12 eating disorder 29.9 CRH LEP POMC
13 acanthosis nigricans 29.9 LEP PRL SHBG
14 acromegaly 29.8 POMC PRL TRH
15 hyperprolactinemia 29.6 GNRH1 POMC PRL SHBG TRH
16 endogenous depression 29.6 CRH GNRH1 TRH
17 pituitary apoplexy 29.5 GNRH1 POMC PRL
18 infertility 29.4 FSHB FSHR GDF9 GNRH1 LHB LHCGR
19 spinocerebellar degeneration 29.4 CRH PRL
20 hypothyroidism 29.2 FSHR LEP POMC PRL SHBG TRH
21 empty sella syndrome 29.2 GNRH1 POMC PRL TRH
22 anovulation 29.2 BMP15 FSHB FSHR GNRH1 LEP PRL
23 hypopituitarism 29.2 CRH GNRH1 POMC PRL
24 hyperthyroidism 29.1 LEP PRL SHBG TRH
25 conn's syndrome 29.1 CRH POMC PRL
26 hypoadrenalism 29.0 CRH POMC SHBG
27 hyperandrogenism 29.0 GNRH1 POMC PRL SHBG WNT4
28 pituitary gland disease 28.5 CRH GNRH1 POMC PRL TRH
29 premenstrual tension 28.4 CRH GNRH1 POMC PRL SHBG
30 ovarian disease 28.3 BMP15 FSHR GDF9 GNRH1 LHCGR NOBOX
31 amenorrhea-galactorrhea syndrome 12.3
32 ahumada del castillo syndrome 11.4
33 mullerian aplasia and hyperandrogenism 11.3
34 ovarian dysgenesis 1 11.3
35 leydig cell hypoplasia, type i 11.3
36 aromatase deficiency 11.3
37 mayer-rokitansky-kuster-hauser syndrome 11.2
38 frasier syndrome 11.2
39 perrault syndrome 11.2
40 ovarian dysgenesis 2 11.1
41 satoyoshi syndrome 11.0
42 leukoencephalopathy with vanishing white matter 11.0
43 premature ovarian failure 10 11.0
44 perrault syndrome 2 11.0
45 premature ovarian failure 8 11.0
46 premature ovarian failure 9 11.0
47 premature ovarian failure 11 11.0
48 ovarian dysgenesis 7 11.0
49 ovarian dysgenesis 8 11.0
50 blepharophimosis, ptosis, and epicanthus inversus 10.9

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


menometrorrhagia, ovulation bleeding

MGI Mouse Phenotypes related to Amenorrhea:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.31 BMP15 CRH FSHB FSHR GDF9 GNRH1
2 homeostasis/metabolism MP:0005376 10.15 CRH FSHB FSHR GDF9 GNRH1 LEP
3 growth/size/body region MP:0005378 10.1 CRH FSHR GNRH1 LEP LHCGR NOBOX
4 integument MP:0010771 9.87 CRH FSHR GNRH1 LEP POMC PRL
5 nervous system MP:0003631 9.85 CRH FSHR GNRH1 LEP LHCGR NR5A1
6 liver/biliary system MP:0005370 9.73 CRH GNRH1 LEP LHCGR POMC PRL
7 renal/urinary system MP:0005367 9.43 CRH GNRH1 LEP LHCGR POMC WNT4
8 reproductive system MP:0005389 9.4 BMP15 FSHB FSHR GDF9 GNRH1 LEP

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 304)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
2
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
4
Cyproterone Acetate Approved, Investigational Phase 4,Not Applicable 427-51-0
5
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
6
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
7
Sargramostim Approved, Investigational Phase 4,Phase 3 123774-72-1, 83869-56-1
8
Lenograstim Approved, Investigational Phase 4,Phase 3 135968-09-1
9
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 71-58-9
10
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 797-63-7, 17489-40-6 13109
11
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
12
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
13
Copper Approved, Investigational Phase 4,Phase 1 7440-50-8 27099
14
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
15
tannic acid Approved Phase 4,Not Applicable 1401-55-4
16
Enoxaparin Approved Phase 4 9005-49-6 772
17
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
18
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
19
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 657181 3911
20
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
21
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
22
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
23
Estrone Approved Phase 4 53-16-7 5870
24
Cetrorelix Approved, Investigational Phase 4 120287-85-6 25074887 16129715
25
Tibolone Approved, Investigational Phase 4 5630-53-5
26
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
28
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
29
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
30
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Not Applicable 15690-57-0
31 Hypoglycemic Agents Phase 4,Early Phase 1,Not Applicable
32 Zuclomiphene Phase 4,Phase 3,Phase 2,Not Applicable
33 Citrate Phase 4,Phase 3,Phase 2,Not Applicable
34 Clomiphene Phase 4,Phase 3,Phase 2,Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42
Cyproterone Phase 4,Not Applicable 2098-66-0 5284537
43 Contraceptive Agents, Male Phase 4,Phase 2,Phase 3,Not Applicable
44 Androgen Antagonists Phase 4,Phase 2,Not Applicable
45 Androgens Phase 4,Phase 2,Not Applicable
46 Mitogens Phase 4
47 Insulin, Globin Zinc Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
48 insulin Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
49 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
50 Nutrients Phase 4,Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 302)
# Name Status NCT ID Phase Drugs
1 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
2 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
3 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
4 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
6 Filgrastim for Premature Ovarian Insufficiency Unknown status NCT02783937 Phase 4 Saline
7 Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak? Unknown status NCT02145819 Phase 4 hCG
8 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients Completed NCT01206153 Phase 4 metformin
9 Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion Completed NCT00160199 Phase 4 PROMETRIUM® 300 mg;PROMETRIUM® 400 mg
10 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
11 "Stair Step Study" Completed NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
12 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
13 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
14 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
15 Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia Completed NCT01165307 Phase 4 Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills;Naproxen sodium pills
16 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
17 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
18 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4 Metformin;Placebo
19 A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). Recruiting NCT02957292 Phase 4 Levonorgestrel (13,5 mg) intrauterine device
20 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Recruiting NCT02937779 Phase 4 Tenofovir disoproxil fumarate
21 Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome Recruiting NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
22 The Kampala Women's Bone Study Recruiting NCT03464266 Phase 4 FTC/TDF;DMPA
23 Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device Active, not recruiting NCT02449304 Phase 4
24 NATural Ovarian Stimulation Active, not recruiting NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®
25 Psychological Impact of Amenorrhea in Women With Endometriosis Not yet recruiting NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
26 The Luveris In Vitro Fertilization Trial Terminated NCT00889512 Phase 4 Luveris fixed dose;Luveris increasing dose
27 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
28 Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception Unknown status NCT02021097 Phase 3 Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg;Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
29 Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum Unknown status NCT01746199 Phase 3 cotrimoxazole daily prophylaxis;sulphadoxine-pyrimethamine
30 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
31 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
32 Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto) Unknown status NCT01583426 Phase 3 nab-Paclitaxel;Paclitaxel
33 LutrePulse Hypogonadotropic Hypogonadism Completed NCT01976728 Phase 3 Gonadorelin acetate subcutaneous (SC) 10 μg/pulse as a fixed dose, administered via. OmniPod pump;Gonadorelin acetate SC 15 μg/pulse as a fixed dose, administered via. OmniPod pump;Gonadorelin acetate SC 20 μg/pulse as a fixed dose, administered via. OmniPod pump;Placebo (SC 10, 15, or 20 μg/pulse as a fixed dose, administered via. OmniPod pump)
34 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
35 Endometrial Safety Study Completed NCT00522873 Phase 3 0.25mg DRSP / 0.5mg E2 (BAY86-4891);0.5mg NETA / 1.0mg E2 (Activella)
36 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01629563 Phase 3 PGL4001 5 mg;PGL4001 10 mg
37 S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer Completed NCT00068601 Phase 3 cyclophosphamide;goserelin acetate
38 A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids Completed NCT00152256 Phase 3 Asoprisnil;Asoprisnil;Placebo
39 Uterine Balloon Treatment for Heavy Period Bleeding. Completed NCT00215618 Phase 3
40 Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE) Completed NCT00502190 Phase 3
41 Gonadotropin-Releasing Hormone Agonist for the Preservation of Ovarian Function During Chemotherapy in Premenopausal Breast Cancer Completed NCT02483767 Phase 3 goserelin;standard chemotherapy
42 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
43 Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer Completed NCT00427245 Phase 3 cyclophosphamide;goserelin acetate
44 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01156857 Phase 3 PGL4001, placebo;PGL4001, progestin
45 Diafert for Embryo Selection and Fertility Improvement (DESTINy) Completed NCT02593513 Phase 3
46 Diafert® for Embryo Selection and Fertility Improvement Completed NCT02593461 Phase 3
47 Diafert for Embryo Selection and Fertility Improvement Completed NCT02586272 Phase 3
48 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3 cyclophosphamide;docetaxel;doxorubicin
49 The Effects of Tualang Honey on Postmenopausal Women Completed NCT01300676 Phase 2, Phase 3 Tualang honey
50 A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Completed NCT01942668 Phase 3 Estradiol;Progesterone;Placebo

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

42
Breast, Pituitary, Ovary, Bone, Testes, Thyroid, Lung

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 1716)
# Title Authors Year
1
Functional hypothalamic amenorrhea: case presentations and overview of literature. ( 29858842 )
2019
2
Adjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients. ( 29878225 )
2019
3
Amenorrhea after lung cancer treatment. ( 30153217 )
2019
4
Levonorgestrel intrauterine system associated amenorrhea: a systematic review and metaanalysis. ( 30527945 )
2019
5
The frequency and predictors of persistent amenorrhea in premenopausal women with colorectal cancer who received adjuvant chemotherapy. ( 30640791 )
2019
6
Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case. ( 30690952 )
2019
7
Functional hypothalamic and drug-induced amenorrhea: an overview. ( 30742257 )
2019
8
Severe metabolic syndrome and primary amenorrhea as main pathophysiological features in a subtype of turner syndrome (46, X, del (X) Q 21). ( 30796876 )
2019
9
Relationships Between Thyroid Hormones, Insulin-Like Growth Factor-1 and Antioxidant Levels in Hypothalamic Amenorrhea and Impact on Bone Metabolism. ( 30847871 )
2019
10
Women With Amenorrhea and Men With Menstruation: The Qualitative Experiences of People With Disorders of Sex Development in Nigeria. ( 30855517 )
2019
11
Sertraline-Related Amenorrhea in an Adolescent. ( 30865005 )
2019
12
Causes Of Primary Amenorrhea At Tertiary Level Hospital. ( 30868785 )
2019
13
Factors that Impact Fertility after Hysteroscopic Adhesiolysis for Intrauterine Adhesions and Amenorrhea: A Retrospective Cohort Study. ( 30880159 )
2019
14
A Study on Chromosomal Analysis of Patients with Primary Amenorrhea. ( 31007464 )
2019
15
Amenorrhea along with renal and thyroid metastasis: Unusual presentation of pancreatic adenocarcinoma. ( 30449933 )
2018
16
Primary Amenorrhea and Endometriosis Secondary to an Unusual Müllerian Anomaly. ( 28461177 )
2018
17
Cytogenetic analysis of patients with primary amenorrhea in Eastern India. ( 29022424 )
2018
18
Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use. ( 29038072 )
2018
19
Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function. ( 29073797 )
2018
20
Bone metabolism in anorexia nervosa and hypothalamic amenorrhea. ( 29107598 )
2018
21
Knowledge and Opinions of Postpartum Mothers About the Lactational Amenorrhea Method: The Turkish Experience. ( 29131679 )
2018
22
Risk of ovarian function recovery should be considered when switching from treatment with adjuvant tamoxifen to aromatase inhibitor therapy in women with chemotherapy-induced amenorrhea. ( 29155450 )
2018
23
Heightened cortisol response to exercise challenge in women with functional hypothalamic amenorrhea. ( 29170001 )
2018
24
Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea. ( 29243847 )
2018
25
A novel de novo autosomal translocation 46, XX, t (5; 8) in a female with primary amenorrhea. ( 29306565 )
2018
26
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea. ( 29403550 )
2018
27
Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens. ( 29601346 )
2018
28
Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy among patients with idiopathic and functional hypothalamic amenorrhea: a systematic review of the literature and a meta-analysis. ( 29605411 )
2018
29
Bone Parameters in Anorexia Nervosa and Athletic Amenorrhea: Comparison of Two Hypothalamic Amenorrhea States. ( 29659886 )
2018
30
Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine. ( 29744355 )
2018
31
Irreversible Primary Amenorrhea Secondary to Uterine Damage and Premature Ovarian Failure in 2 Patients with Ewing Sarcoma. ( 29857112 )
2018
32
Exercise and chemotherapy-induced amenorrhea. ( 29857911 )
2018
33
Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report. ( 29949817 )
2018
34
Sellar chondrosarcoma presenting with amenorrhea: A case report. ( 29979394 )
2018
35
Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case. ( 30121986 )
2018
36
FXPOI: Pattern of AGG Interruptions Does not Show an Association With Age at Amenorrhea Among Women With a Premutation. ( 30123240 )
2018
37
Müllerian Agenesis Masquerading as Secondary Amenorrhea. ( 30123604 )
2018
38
Prognostic Significance of Adjuvant Chemotherapy Induced Amenorrhea in Luminal A and B Subtypes. ( 30123884 )
2018
39
Primary pigmented nodular adrenocortical disease (PPNAD) as an underlying cause of symptoms in a patient presenting with hirsutism and secondary amenorrhea: case report and literature review. ( 30129786 )
2018
40
The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial. ( 30159278 )
2018
41
Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature. ( 30166053 )
2018
42
Knowledge and associated factors of lactational amenorrhea as a contraception method among postpartum women in Aksum town, Tigray Region, Ethiopia. ( 30176910 )
2018
43
Evaluation of menopausal status among breast cancer patients with chemotherapy-induced amenorrhea. ( 30210227 )
2018
44
The role of electrocardiogram in sex verification in a young adult with primary amenorrhea: a case report. ( 30220253 )
2018
45
Prolonged Amenorrhea and Resumption of Menses in Women with HIV. ( 30222490 )
2018
46
Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial. ( 30370852 )
2018
47
HIV and amenorrhea: A meta-analysis. ( 30531313 )
2018
48
Pyridoxine for the treatment of quetiapine-induced hyperprolactinemia and amenorrhea: A case report. ( 30584026 )
2018
49
Tectal glioma presenting with clinical triad of obesity, amenorrhea and central cord syndrome with radiological pentad of hydrocephalus, empty sella, suprapineal diverticula, Chiari and syrinx. ( 27757566 )
2017
50
Feature of amenorrhea in postoperative tamoxifen users with breast cancer. ( 27894163 )
2017

Variations for Amenorrhea

ClinVar genetic disease variations for Amenorrhea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance rs1553340669 GRCh37 Chromosome 2, 49295440: 49295440
2 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance rs1553340669 GRCh38 Chromosome 2, 49068301: 49068301
3 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh38 Chromosome 2, 49154416: 49154416
4 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh37 Chromosome 2, 49381555: 49381555

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 CRH FSHB FSHR GNRH1 LEP LHB
2
Show member pathways
12.82 FSHB FSHR LHB LHCGR NR5A1 POMC
3
Show member pathways
12.23 LEP LHB LHCGR PRL
4
Show member pathways
11.97 FSHB LEP LHB POMC
5
Show member pathways
11.82 BMP15 GDF9 GNRH1 LHB
6 11.8 CRH FSHB FSHR LHB LHCGR POMC
7 11.13 FSHR GDF9 LHCGR NR5A1
8 11.04 BMP15 FSHB FSHR LHB LHCGR
9
Show member pathways
11.02 LEP POMC TRH
10 10.89 FSHB FSHR
11 10.75 GNRH1 SHBG
12 10.3 CRH POMC
13 10.14 FSHB FSHR GNRH1 LHB LHCGR

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 BMP15 CRH FSHB GDF9 GNRH1 LEP
2 extracellular region GO:0005576 9.4 BMP15 CRH FSHB GDF9 GNRH1 LEP
3 secretory granule GO:0030141 9.16 POMC TRH

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.88 GNRH1 LHB POMC TRH
2 regulation of MAPK cascade GO:0043408 9.73 BMP15 FSHR GDF9
3 male gonad development GO:0008584 9.72 FSHR LHB LHCGR NR5A1 WNT4
4 response to ethanol GO:0045471 9.67 CRH GNRH1 LEP TRH
5 female gonad development GO:0008585 9.65 FSHR NR5A1 WNT4
6 female pregnancy GO:0007565 9.65 CRH FSHB GNRH1 LEP PRL
7 positive regulation of JAK-STAT cascade GO:0046427 9.64 LEP PRL
8 eating behavior GO:0042755 9.64 LEP TRH
9 response to organic cyclic compound GO:0014070 9.63 GNRH1 TRH
10 peptide hormone processing GO:0016486 9.63 FSHB LHB
11 adrenal gland development GO:0030325 9.63 CRH NR5A1 WNT4
12 response to corticosterone GO:0051412 9.62 CRH TRH
13 regulation of osteoclast differentiation GO:0045670 9.62 FSHB FSHR
14 male sex determination GO:0030238 9.61 GNRH1 NR5A1
15 regulation of steroid biosynthetic process GO:0050810 9.58 LEP NR5A1
16 hormone metabolic process GO:0042445 9.58 LEP NR5A1 WNT4
17 negative regulation of glucagon secretion GO:0070093 9.55 CRH LEP
18 ovulation cycle process GO:0022602 9.54 FSHR LHCGR
19 Sertoli cell proliferation GO:0060011 9.52 FSHB FSHR
20 follicle-stimulating hormone signaling pathway GO:0042699 9.51 FSHB FSHR
21 progesterone biosynthetic process GO:0006701 9.49 FSHB LHB
22 female gamete generation GO:0007292 9.46 BMP15 FSHB FSHR GDF9
23 hormone-mediated signaling pathway GO:0009755 9.43 FSHB FSHR LHB LHCGR NR5A1 TRH
24 regulation of signaling receptor activity GO:0010469 9.32 BMP15 FSHB GDF9 GNRH1 LEP LHB
25 parturition GO:0007567 9.3 CRH
26 ovulation cycle GO:0042698 9.29 GNRH1
27 signal transduction GO:0007165 10.17 CRH FSHR GNRH1 LEP LHB LHCGR
28 G protein-coupled receptor signaling pathway GO:0007186 10.03 CRH FSHB FSHR GNRH1 LHB LHCGR
29 positive regulation of cell proliferation GO:0008284 10 CRH FSHB GDF9 LEP PRL

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 CRH LEP LHB POMC WNT4
2 hormone activity GO:0005179 9.23 CRH FSHB GNRH1 LEP LHB POMC
3 protein-hormone receptor activity GO:0016500 9.16 FSHR LHCGR

Sources for Amenorrhea

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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