Aliases & Classifications for Amenorrhea

MalaCards integrated aliases for Amenorrhea:

Name: Amenorrhea 12 76 29 6 44 15 73
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD10 33 N91.2
ICD9CM 35 626.0
MeSH 44 D000568
NCIt 50 C61443
SNOMED-CT 68 14302001
UMLS 73 C0002453

Summaries for Amenorrhea

Disease Ontology : 12 A female reproductive system disease that is characterized by the absence of menstruation.

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to hypogonadotropic hypogonadism 23 without anosmia and anorexia nervosa, and has symptoms including menometrorrhagia and ovulation bleeding. An important gene associated with Amenorrhea is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Estradiol and Leuprolide have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 76 Amenorrhea is the absence of a menstrual period in a woman of reproductive age. Physiological states of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 31.6 FSHR GNRH1 LHB
2 anorexia nervosa 31.6 CRH LEP POMC PRL
3 polycystic ovary syndrome 31.6 FSHR GNRH1 LEP PRL SHBG
4 pituitary adenoma, prolactin-secreting 31.5 POMC PRL TRH
5 premature ovarian failure 1 31.1 BMP15 FSHR GNRH1 NOBOX NR5A1 POF1B
6 gonadal dysgenesis 30.0 BMP15 FSHR NR5A1 SRY
7 eating disorder 30.0 CRH LEP POMC
8 hyperprolactinemia 30.0 GNRH1 POMC PRL SHBG TRH
9 diabetes insipidus 30.0 CRH POMC PRL
10 hypogonadism 30.0 FSHB GNRH1 LHB LHCGR
11 acanthosis nigricans 29.9 LEP PRL SHBG
12 endometriosis 29.9 GNRH1 NR5A1 WNT4
13 acromegaly 29.9 POMC PRL TRH
14 46 xy gonadal dysgenesis 29.8 NR5A1 SHBG SRY
15 craniopharyngioma 29.7 GNRH1 PRL TRH
16 hypothyroidism 29.7 FSHR LEP POMC PRL SHBG TRH
17 infertility 29.7 FSHB FSHR GNRH1 LHB LHCGR NR5A1
18 anovulation 29.6 BMP15 FSHB FSHR GNRH1 LEP PRL
19 endogenous depression 29.6 CRH GNRH1 TRH
20 androgen insensitivity syndrome 29.6 NR5A1 SHBG SRY
21 pituitary apoplexy 29.6 GNRH1 POMC PRL
22 hypothalamic disease 29.5 CRH GNRH1 POMC PRL
23 empty sella syndrome 29.5 GNRH1 POMC PRL TRH
24 lipoid congenital adrenal hyperplasia 29.4 NR5A1 POMC SRY
25 spinocerebellar degeneration 29.4 CRH PRL
26 hyperandrogenism 29.4 GNRH1 POMC PRL SHBG WNT4
27 hypopituitarism 29.4 CRH GNRH1 POMC PRL
28 hyperthyroidism 29.3 LEP PRL SHBG TRH
29 ovarian disease 29.2 BMP15 FSHR GNRH1 LHCGR NOBOX NR5A1
30 conn's syndrome 29.2 CRH POMC PRL
31 hypoadrenalism 29.2 CRH POMC SHBG
32 pituitary gland disease 28.9 CRH GNRH1 POMC PRL TRH
33 amenorrhea-galactorrhea syndrome 12.2
34 ahumada del castillo syndrome 11.3
35 aromatase deficiency 11.3
36 mayer-rokitansky-kuster-hauser syndrome 11.2
37 frasier syndrome 11.2
38 perrault syndrome 11.2
39 ovarian dysgenesis 2 11.1
40 mullerian aplasia and hyperandrogenism 11.0
41 ovarian dysgenesis 1 11.0
42 leydig cell hypoplasia, type i 11.0
43 satoyoshi syndrome 11.0
44 leukoencephalopathy with vanishing white matter 11.0
45 premature ovarian failure 10 11.0
46 perrault syndrome 2 11.0
47 premature ovarian failure 8 11.0
48 premature ovarian failure 9 11.0
49 premature ovarian failure 11 11.0
50 blepharophimosis, ptosis, and epicanthus inversus 10.8

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


menometrorrhagia, ovulation bleeding

MGI Mouse Phenotypes related to Amenorrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.28 BMP15 CRH FSHB FSHR GNRH1 LEP
2 homeostasis/metabolism MP:0005376 10.11 CRH FSHB FSHR GNRH1 LEP LHB
3 growth/size/body region MP:0005378 10.1 CRH FSHR GNRH1 LEP LHCGR NOBOX
4 nervous system MP:0003631 9.9 CRH FSHR GNRH1 LEP LHCGR NOBOX
5 integument MP:0010771 9.87 CRH FSHR GNRH1 LEP POMC PRL
6 liver/biliary system MP:0005370 9.73 CRH GNRH1 LEP LHCGR POMC PRL
7 renal/urinary system MP:0005367 9.43 CRH GNRH1 LEP LHCGR POMC WNT4
8 reproductive system MP:0005389 9.36 BMP15 FSHB FSHR GNRH1 LEP LHB

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 288)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
2
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 657181 3911
3
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 17489-40-6, 797-63-7 13109
4
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
5
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
6
Tibolone Approved, Investigational Phase 4 5630-53-5
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
8
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
9
Cyproterone Acetate Approved, Investigational Phase 4,Not Applicable 427-51-0
10
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
11
Lenograstim Approved, Investigational Phase 4,Phase 3 135968-09-1
12
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 71-58-9
13
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
14
Copper Approved, Investigational Phase 4,Phase 1 7440-50-8 27099
15
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
16
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
17
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
18
Enoxaparin Approved Phase 4 9005-49-6 772
19
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
20 tannic acid Approved Phase 4,Not Applicable
21
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
22
Estrone Approved Phase 4 53-16-7 5870
23
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
24
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
25
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
27
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Not Applicable 15690-57-0
28
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
29 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
31 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Calciferol Phase 4,Phase 3
33 Antacids Phase 4,Phase 3,Not Applicable
34 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Antihypertensive Agents Phase 4
36 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Not Applicable
37 Trace Elements Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Androgen Antagonists Phase 4,Phase 2,Not Applicable
40 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
41 Vitamins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Anti-Ulcer Agents Phase 4,Phase 3,Not Applicable
43 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Androgens Phase 4,Phase 2,Not Applicable
48 Anabolic Agents Phase 4,Phase 2
49 Bone Density Conservation Agents Phase 4,Phase 3,Not Applicable
50 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 291)
# Name Status NCT ID Phase Drugs
1 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
2 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
3 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
4 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
5 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
6 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
7 Filgrastim for Premature Ovarian Insufficiency Unknown status NCT02783937 Phase 4 Saline
8 Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak? Unknown status NCT02145819 Phase 4 hCG
9 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients Completed NCT01206153 Phase 4 metformin
10 Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion Completed NCT00160199 Phase 4 PROMETRIUM® 300 mg;PROMETRIUM® 400 mg
11 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
12 "Stair Step Study" Completed NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
13 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
14 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
15 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
16 Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia Completed NCT01165307 Phase 4 Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills;Naproxen sodium pills
17 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
18 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
19 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4 Metformin;Placebo
20 A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). Recruiting NCT02957292 Phase 4 Levonorgestrel (13,5 mg) intrauterine device
21 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Recruiting NCT02937779 Phase 4 Tenofovir disoproxil fumarate
22 Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome Recruiting NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
23 The Kampala Women's Bone Study Recruiting NCT03464266 Phase 4 FTC/TDF;DMPA
24 Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device Active, not recruiting NCT02449304 Phase 4
25 NATural Ovarian Stimulation Active, not recruiting NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®
26 The Luveris In Vitro Fertilization Trial Terminated NCT00889512 Phase 4 Luveris fixed dose;Luveris increasing dose
27 HexafluOride, a Contrast Agent for Placenta Echo-angiography Unknown status NCT02884297 Phase 3 Contrast agent: SonoVue®.
28 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
29 Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception Unknown status NCT02021097 Phase 3 Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg;Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
30 Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum Unknown status NCT01746199 Phase 3 cotrimoxazole daily prophylaxis;sulphadoxine-pyrimethamine
31 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
32 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
33 Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto) Unknown status NCT01583426 Phase 3 nab-Paclitaxel;Paclitaxel
34 LutrePulse Hypogonadotropic Hypogonadism Completed NCT01976728 Phase 3 Gonadorelin acetate 10µg/pulse;Gonadorelin acetate 15µg/pulse;Gonadorelin acetate 20µg/pulse;Placebo
35 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
36 Endometrial Safety Study Completed NCT00522873 Phase 3 0.25mg DRSP / 0.5mg E2 (BAY86-4891);0.5mg NETA / 1.0mg E2 (Activella)
37 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01629563 Phase 3 PGL4001 5 mg;PGL4001 10 mg
38 S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer Completed NCT00068601 Phase 3 cyclophosphamide;goserelin acetate
39 A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids Completed NCT00152256 Phase 3 Asoprisnil;Asoprisnil;Placebo
40 Uterine Balloon Treatment for Heavy Period Bleeding. Completed NCT00215618 Phase 3
41 Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE) Completed NCT00502190 Phase 3
42 Gonadotropin-Releasing Hormone Agonist for the Preservation of Ovarian Function During Chemotherapy in Premenopausal Breast Cancer Completed NCT02483767 Phase 3 goserelin;standard chemotherapy
43 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
44 Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer Completed NCT00427245 Phase 3 cyclophosphamide;goserelin acetate
45 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01156857 Phase 3 PGL4001, placebo;PGL4001, progestin
46 Diafert for Embryo Selection and Fertility Improvement (DESTINy) Completed NCT02593513 Phase 3
47 Diafert® for Embryo Selection and Fertility Improvement Completed NCT02593461 Phase 3
48 Diafert for Embryo Selection and Fertility Improvement Completed NCT02586272 Phase 3
49 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3 cyclophosphamide;docetaxel;doxorubicin
50 The Effects of Tualang Honey on Postmenopausal Women Completed NCT01300676 Phase 2, Phase 3 Tualang honey

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Genetic tests related to Amenorrhea:

# Genetic test Affiliating Genes
1 Amenorrhea 29

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

41
Breast, Bone, Ovary, Pituitary, Testes, Kidney, Thyroid

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 1185)
# Title Authors Year
1
Sellar chondrosarcoma presenting with amenorrhea: A case report. ( 29979394 )
2018
2
Heightened cortisol response to exercise challenge in women with functional hypothalamic amenorrhea. ( 29170001 )
2018
3
Adjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients. ( 29878225 )
2018
4
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea. ( 29403550 )
2018
5
Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy among patients with idiopathic and functional hypothalamic amenorrhea: a systematic review of the literature and a meta-analysis. ( 29605411 )
2018
6
Bone Parameters in Anorexia Nervosa and Athletic Amenorrhea: Comparison of Two Hypothalamic Amenorrhea States. ( 29659886 )
2018
7
Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report. ( 29949817 )
2018
8
Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens. ( 29601346 )
2018
9
Amenorrhea ( 29489290 )
2018
10
Exercise and chemotherapy-induced amenorrhea. ( 29857911 )
2018
11
Cytogenetic analysis of patients with primary amenorrhea in Eastern India. ( 29022424 )
2018
12
Functional hypothalamic amenorrhea: case presentations and overview of literature. ( 29858842 )
2018
13
A novel de novo autosomal translocation 46, XX, t (5; 8) in a female with primary amenorrhea. ( 29306565 )
2018
14
Knowledge and Opinions of Postpartum Mothers About the Lactational Amenorrhea Method: The Turkish Experience. ( 29131679 )
2018
15
Risk of ovarian function recovery should be considered when switching from treatment with adjuvant tamoxifen to aromatase inhibitor therapy in women with chemotherapy-induced amenorrhea. ( 29155450 )
2018
16
Irreversible primary amenorrhea secondary to uterine damage and premature ovarian failure in Ewing's sarcoma in two patients. ( 29857112 )
2018
17
Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine. ( 29744355 )
2018
18
Amenorrhea along with renal and thyroid metastasis: Unusual presentation of pancreatic adenocarcinoma. ( 30449933 )
2018
19
Bone metabolism in anorexia nervosa and hypothalamic amenorrhea. ( 29107598 )
2018
20
Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case. ( 30121986 )
2018
21
FXPOI: Pattern of AGG Interruptions Does not Show an Association With Age at Amenorrhea Among Women With a Premutation. ( 30123240 )
2018
22
Müllerian Agenesis Masquerading as Secondary Amenorrhea. ( 30123604 )
2018
23
Prognostic Significance of Adjuvant Chemotherapy Induced Amenorrhea in Luminal A and B Subtypes. ( 30123884 )
2018
24
Primary pigmented nodular adrenocortical disease (PPNAD) as an underlying cause of symptoms in a patient presenting with hirsutism and secondary amenorrhea: case report and literature review. ( 30129786 )
2018
25
Amenorrhea after lung cancer treatment. ( 30153217 )
2018
26
The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial. ( 30159278 )
2018
27
Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature. ( 30166053 )
2018
28
Knowledge and associated factors of lactational amenorrhea as a contraception method among postpartum women in Aksum town, Tigray Region, Ethiopia. ( 30176910 )
2018
29
Evaluation of menopausal status among breast cancer patients with chemotherapy-induced amenorrhea. ( 30210227 )
2018
30
The role of electrocardiogram in sex verification in a young adult with primary amenorrhea: a case report. ( 30220253 )
2018
31
Prolonged Amenorrhea and Resumption of Menses in Women with HIV. ( 30222490 )
2018
32
Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial. ( 30370852 )
2018
33
Levonorgestrel Intrauterine System associated amenorrhea: a systematic review and meta-analysis. ( 30527945 )
2018
34
HIV and amenorrhea: A meta-analysis. ( 30531313 )
2018
35
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
36
Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. ( 28368518 )
2017
37
Amenorrhea, Secondary ( 28613709 )
2017
38
Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents. ( 29142910 )
2017
39
Plasma kisspeptin levels in lactational amenorrhea. ( 28490208 )
2017
40
Partial Hydatiform Mole Associated With a Pregnancy at 22 Weeks of Amenorrhea. ( 28286033 )
2017
41
Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea. ( 29264460 )
2017
42
Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea. ( 28833893 )
2017
43
Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function. ( 29073797 )
2017
44
Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use. ( 29038072 )
2017
45
Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea. ( 28360449 )
2017
46
Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrhea. ( 28959377 )
2017
47
Risperidone-Induced Amenorrhea in Floridly Psychotic Female. ( 29152440 )
2017
48
Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency. ( 28485330 )
2017
49
Spectrum of MRI Appearance of Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome in Primary Amenorrhea Patients. ( 28893003 )
2017
50
Predictors of menstruation restoration during metformin administration for treatment of antipsychotic drug-induced amenorrhea: A post hoc analysis. ( 28292552 )
2017

Variations for Amenorrhea

ClinVar genetic disease variations for Amenorrhea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance GRCh37 Chromosome 2, 49295440: 49295440
2 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance GRCh38 Chromosome 2, 49068301: 49068301
3 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh38 Chromosome 2, 49154416: 49154416
4 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh37 Chromosome 2, 49381555: 49381555

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CRH FSHB FSHR GNRH1 LEP LHB
2
Show member pathways
13.26 CRH FSHB FSHR GNRH1 LEP LHB
3
Show member pathways
12.82 FSHB FSHR LHB LHCGR NR5A1 POMC
4
Show member pathways
12.25 LEP LHB LHCGR PRL
5
Show member pathways
12.18 CRH NR5A1 POMC WNT4
6
Show member pathways
11.97 FSHB LEP LHB POMC
7 11.8 CRH FSHB FSHR LHB LHCGR POMC
8 11.05 FSHR LHCGR NR5A1
9 11.04 BMP15 FSHB FSHR LHB LHCGR
10
Show member pathways
10.97 LEP POMC TRH
11 10.9 FSHB FSHR
12 10.78 GNRH1 SHBG
13 10.3 CRH POMC
14 10.14 FSHB FSHR GNRH1 LHB LHCGR

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 BMP15 CRH FSHB GNRH1 LEP LHB
2 extracellular region GO:0005576 9.36 BMP15 CRH FSHB GNRH1 LEP LHB
3 secretory granule GO:0030141 9.33 POMC PRL TRH

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.9 GNRH1 LHB POMC TRH
2 response to organic cyclic compound GO:0014070 9.81 GNRH1 PRL TRH
3 response to ethanol GO:0045471 9.72 CRH GNRH1 LEP PRL TRH
4 female gonad development GO:0008585 9.67 FSHR NR5A1 WNT4
5 positive regulation of JAK-STAT cascade GO:0046427 9.65 LEP PRL
6 adrenal gland development GO:0030325 9.65 CRH NR5A1 WNT4
7 male gonad development GO:0008584 9.65 FSHR LHB LHCGR NR5A1 WNT4
8 eating behavior GO:0042755 9.64 LEP TRH
9 sex differentiation GO:0007548 9.64 SRY WNT4
10 peptide hormone processing GO:0016486 9.63 FSHB LHB
11 response to corticosterone GO:0051412 9.62 CRH TRH
12 regulation of osteoclast differentiation GO:0045670 9.62 FSHB FSHR
13 parturition GO:0007567 9.61 CRH PRL
14 ovulation cycle GO:0042698 9.61 GNRH1 PRL
15 female gamete generation GO:0007292 9.61 BMP15 FSHB FSHR
16 regulation of signaling receptor activity GO:0010469 9.61 BMP15 FSHB GNRH1 LEP LHB POMC
17 positive regulation of adenylate cyclase activity GO:0045762 9.59 FSHR LHCGR
18 positive regulation of male gonad development GO:2000020 9.58 NR5A1 SRY
19 regulation of steroid biosynthetic process GO:0050810 9.58 LEP NR5A1
20 hormone metabolic process GO:0042445 9.58 LEP NR5A1 WNT4
21 negative regulation of glucagon secretion GO:0070093 9.56 CRH LEP
22 ovulation cycle process GO:0022602 9.55 FSHR LHCGR
23 female pregnancy GO:0007565 9.55 CRH FSHB GNRH1 LEP PRL
24 Sertoli cell proliferation GO:0060011 9.54 FSHB FSHR
25 male sex determination GO:0030238 9.54 GNRH1 NR5A1 SRY
26 follicle-stimulating hormone signaling pathway GO:0042699 9.52 FSHB FSHR
27 progesterone biosynthetic process GO:0006701 9.51 FSHB LHB
28 hormone-mediated signaling pathway GO:0009755 9.1 FSHB FSHR LHB LHCGR NR5A1 TRH
29 signal transduction GO:0007165 10.17 CRH FSHR GNRH1 LEP LHB LHCGR
30 G protein-coupled receptor signaling pathway GO:0007186 10.06 CRH FSHB FSHR GNRH1 LHB LHCGR

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 CRH LEP LHB POMC WNT4
2 hormone activity GO:0005179 9.23 CRH FSHB GNRH1 LEP LHB POMC
3 protein-hormone receptor activity GO:0016500 9.16 FSHR LHCGR

Sources for Amenorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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