Aliases & Classifications for Amenorrhea

MalaCards integrated aliases for Amenorrhea:

Name: Amenorrhea 12 76 29 6 44 15 73
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD10 33 N91.2
ICD9CM 35 626.0
MeSH 44 D000568
NCIt 50 C61443
UMLS 73 C0002453

Summaries for Amenorrhea

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to hypogonadotropic hypogonadism 23 without anosmia and polycystic ovary syndrome, and has symptoms including ovulation bleeding and menometrorrhagia. An important gene associated with Amenorrhea is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Calcium Carbonate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 76 Amenorrhoea is the absence of a menstrual period in a woman of reproductive age. Physiological states of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 31.7 FSHR GNRH1 LHB
2 polycystic ovary syndrome 30.8 FSHR GNRH1 LEP PRL SHBG
3 hypogonadotropism 30.6 GNRH1 PRL
4 pituitary adenoma, prolactin-secreting 30.4 POMC PRL TRH
5 acanthosis nigricans 29.9 LEP PRL SHBG
6 endometriosis 29.9 GNRH1 NR5A1 WNT4
7 premature ovarian failure 1 29.7 BMP15 FSHR GNRH1 NOBOX NR5A1 POF1B
8 hypogonadism 29.6 FSHB GNRH1 LHB LHCGR
9 gonadal dysgenesis 29.5 BMP15 FSHR NR5A1 SRY
10 anorexia nervosa 29.4 CRH LEP POMC PRL
11 diabetes insipidus 29.3 CRH POMC PRL
12 craniopharyngioma 29.3 GNRH1 PRL TRH
13 46 xy gonadal dysgenesis 29.3 NR5A1 SHBG SRY
14 eating disorder 29.2 CRH LEP POMC
15 androgen insensitivity syndrome 29.2 NR5A1 SHBG SRY
16 pituitary apoplexy 29.1 GNRH1 POMC PRL
17 acromegaly 29.0 POMC PRL TRH
18 hermaphroditism 29.0 SHBG SRY WNT4
19 hyperthyroidism 28.7 LEP PRL SHBG TRH
20 lipoid congenital adrenal hyperplasia 28.5 NR5A1 POMC SRY
21 infertility 28.5 FSHB FSHR GNRH1 LHB LHCGR NR5A1
22 hypoadrenalism 28.4 CRH POMC SHBG
23 hypopituitarism 28.4 CRH GNRH1 POMC PRL
24 empty sella syndrome 28.3 GNRH1 POMC PRL TRH
25 hypothalamic disease 28.2 CRH GNRH1 POMC PRL
26 hyperandrogenism 28.1 GNRH1 POMC PRL SHBG WNT4
27 anovulation 28.1 BMP15 FSHB FSHR GNRH1 LEP PRL
28 hyperprolactinemia 27.9 GNRH1 POMC PRL SHBG TRH
29 endogenous depression 27.9 CRH GNRH1 POMC TRH
30 ovarian disease 27.6 BMP15 FSHR GNRH1 NOBOX NR5A1 POF1B
31 hypothyroidism 27.4 FSHR LEP POMC PRL SHBG TRH
32 amenorrhea-galactorrhea syndrome 12.1
33 ahumada del castillo syndrome 11.2
34 aromatase deficiency 11.2
35 frasier syndrome 11.0
36 hypogonadotropic hypogonadism 24 without anosmia 11.0
37 perrault syndrome 11.0
38 ovarian dysgenesis 2 10.9
39 ovarian dysgenesis 1 10.8
40 leydig cell hypoplasia, type i 10.8
41 satoyoshi syndrome 10.8
42 leukoencephalopathy with vanishing white matter 10.8
43 premature ovarian failure 10 10.8
44 perrault syndrome 2 10.8
45 premature ovarian failure 8 10.8
46 premature ovarian failure 9 10.8
47 premature ovarian failure 11 10.8
48 precocious puberty, male-limited 10.8 FSHR LHCGR
49 hypogonadism, male 10.7 LEP LHCGR
50 blepharophimosis, ptosis, and epicanthus inversus 10.7

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


ovulation bleeding, menometrorrhagia

MGI Mouse Phenotypes related to Amenorrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.25 BMP15 CRH FSHB FSHR GNRH1 LEP
2 growth/size/body region MP:0005378 10.07 LHCGR NOBOX NR5A1 POMC TRH CRH
3 homeostasis/metabolism MP:0005376 10.06 CRH FSHB FSHR GNRH1 LEP LHB
4 nervous system MP:0003631 9.9 CRH FSHR GNRH1 LEP LHCGR NOBOX
5 integument MP:0010771 9.8 CRH FSHR GNRH1 LEP POMC PRL
6 renal/urinary system MP:0005367 9.43 CRH GNRH1 LEP LHCGR POMC WNT4
7 reproductive system MP:0005389 9.36 PRL WNT4 BMP15 FSHB FSHR GNRH1

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 252)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
4
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 3911 657181
5
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 797-63-7, 17489-40-6 13109
6
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
7
Tibolone Approved, Investigational Phase 4 5630-53-5
8
Metformin Approved Phase 4,Not Applicable 657-24-9 14219 4091
9
Cyproterone Acetate Approved, Investigational Phase 4,Not Applicable 427-51-0
10
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
11
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
12
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 71-58-9
13
Copper Approved, Investigational Phase 4,Phase 1 7440-50-8 27099
14
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
15
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
16
Lenograstim Approved, Investigational Phase 4,Phase 3 135968-09-1
17
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
18
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
19
Estrone Approved Phase 4 53-16-7 5870
20
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
21
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
22
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
24
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Not Applicable 15690-57-0
25 Anabolic Agents Phase 4,Phase 2
26 Androgen Antagonists Phase 4,Phase 2,Not Applicable
27 Androgens Phase 4,Phase 2,Not Applicable
28 Antacids Phase 4,Phase 3,Not Applicable
29 Antihypertensive Agents Phase 4
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
31 Anti-Ulcer Agents Phase 4,Phase 3,Not Applicable
32 Bone Density Conservation Agents Phase 4,Phase 3,Not Applicable
33 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
34 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Not Applicable
38 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Fertility Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2
45 Trace Elements Phase 4,Phase 3,Phase 1,Phase 2
46 Vitamins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Clomiphene Phase 4,Phase 3,Phase 2,Not Applicable
48 Hypoglycemic Agents Phase 4,Early Phase 1,Not Applicable
49 Zuclomiphene Phase 4,Phase 3,Phase 2,Not Applicable
50 Contraceptive Agents, Male Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 271)
# Name Status NCT ID Phase Drugs
1 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
2 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
3 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
4 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
6 Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak? Unknown status NCT02145819 Phase 4 hCG
7 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients Completed NCT01206153 Phase 4 metformin
8 Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion Completed NCT00160199 Phase 4 PROMETRIUM® 300 mg;PROMETRIUM® 400 mg
9 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
10 "Stair Step Study" Completed NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
11 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
12 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
13 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
14 Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia Completed NCT01165307 Phase 4 Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills;Naproxen sodium pills
15 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
16 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4 Metformin;Placebo
17 A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). Recruiting NCT02957292 Phase 4 Levonorgestrel (13,5 mg) intrauterine device
18 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Recruiting NCT02937779 Phase 4 Tenofovir disoproxil fumarate
19 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Recruiting NCT02904070 Phase 4
20 Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome Recruiting NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
21 ENOXAPARINE in the Prevention of Placental Insufficiency in Pregnant Women Recruiting NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
22 Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device Active, not recruiting NCT02449304 Phase 4
23 NATural Ovarian Stimulation Active, not recruiting NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®
24 Filgrastim for Premature Ovarian Insufficiency Active, not recruiting NCT02783937 Phase 4 Saline
25 The Kampala Women's Bone Study Not yet recruiting NCT03464266 Phase 4 FTC/TDF;DMPA
26 The Luveris In Vitro Fertilization Trial Terminated NCT00889512 Phase 4 Luveris fixed dose;Luveris increasing dose
27 HexafluOride, a Contrast Agent for Placenta Echo-angiography Unknown status NCT02884297 Phase 3 Contrast agent: SonoVue®.
28 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
29 Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception Unknown status NCT02021097 Phase 3 Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg;Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
30 Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum Unknown status NCT01746199 Phase 3 cotrimoxazole daily prophylaxis;sulphadoxine-pyrimethamine
31 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
32 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
33 LutrePulse Hypogonadotropic Hypogonadism Completed NCT01976728 Phase 3 Gonadorelin acetate 10µg/pulse;Gonadorelin acetate 15µg/pulse;Gonadorelin acetate 20µg/pulse;Placebo
34 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
35 Endometrial Safety Study Completed NCT00522873 Phase 3 0.25mg DRSP / 0.5mg E2 (BAY86-4891);0.5mg NETA / 1.0mg E2 (Activella)
36 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01629563 Phase 3 PGL4001 5 mg;PGL4001 10 mg
37 S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer Completed NCT00068601 Phase 3 cyclophosphamide;goserelin acetate
38 A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids Completed NCT00152256 Phase 3 Asoprisnil;Asoprisnil;Placebo
39 Uterine Balloon Treatment for Heavy Period Bleeding. Completed NCT00215618 Phase 3
40 Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE) Completed NCT00502190 Phase 3
41 Gonadotropin-Releasing Hormone Agonist for the Preservation of Ovarian Function During Chemotherapy in Premenopausal Breast Cancer Completed NCT02483767 Phase 3 goserelin;standard chemotherapy
42 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
43 Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer Completed NCT00427245 Phase 3 cyclophosphamide;goserelin acetate
44 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01156857 Phase 3 PGL4001, placebo;PGL4001, progestin
45 Diafert for Embryo Selection and Fertility Improvement (DESTINy) Completed NCT02593513 Phase 3
46 Diafert® for Embryo Selection and Fertility Improvement Completed NCT02593461 Phase 3
47 Diafert for Embryo Selection and Fertility Improvement Completed NCT02586272 Phase 3
48 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3 cyclophosphamide;docetaxel;doxorubicin
49 The Effects of Tualang Honey on Postmenopausal Women Completed NCT01300676 Phase 2, Phase 3 Tualang honey
50 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed NCT00088153 Phase 2, Phase 3 Physiologic Estrogen/progesterone

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Genetic tests related to Amenorrhea:

# Genetic test Affiliating Genes
1 Amenorrhea 29

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

41
Breast, Ovary, Bone, Pituitary, Testes, Brain, Monocytes

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 742)
# Title Authors Year
1
Sellar chondrosarcoma presenting with amenorrhea: A case report. ( 29979394 )
2018
2
Heightened cortisol response to exercise challenge in women with functional hypothalamic amenorrhea. ( 29170001 )
2018
3
Adjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients. ( 29878225 )
2018
4
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea. ( 29403550 )
2018
5
Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy among patients with idiopathic and functional hypothalamic amenorrhea: a systematic review of the literature and a meta-analysis. ( 29605411 )
2018
6
Bone Parameters in Anorexia Nervosa and Athletic Amenorrhea: Comparison of Two Hypothalamic Amenorrhea States. ( 29659886 )
2018
7
Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report. ( 29949817 )
2018
8
Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens. ( 29601346 )
2018
9
Amenorrhea ( 29489290 )
2018
10
Exercise and chemotherapy-induced amenorrhea. ( 29857911 )
2018
11
Cytogenetic analysis of patients with primary amenorrhea in Eastern India. ( 29022424 )
2018
12
Functional hypothalamic amenorrhea: case presentations and overview of literature. ( 29858842 )
2018
13
A novel de novo autosomal translocation 46, XX, t (5; 8) in a female with primary amenorrhea. ( 29306565 )
2018
14
Knowledge and Opinions of Postpartum Mothers About the Lactational Amenorrhea Method: The Turkish Experience. ( 29131679 )
2018
15
Risk of ovarian function recovery should be considered when switching from treatment with adjuvant tamoxifen to aromatase inhibitor therapy in women with chemotherapy-induced amenorrhea. ( 29155450 )
2018
16
Irreversible primary amenorrhea secondary to uterine damage and premature ovarian failure in Ewing's sarcoma in two patients. ( 29857112 )
2018
17
Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine. ( 29744355 )
2018
18
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
19
Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. ( 28368518 )
2017
20
Amenorrhea, Secondary ( 28613709 )
2017
21
Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents. ( 29142910 )
2017
22
Plasma kisspeptin levels in lactational amenorrhea. ( 28490208 )
2017
23
Partial Hydatiform Mole Associated With a Pregnancy at 22 Weeks of Amenorrhea. ( 28286033 )
2017
24
Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea. ( 29264460 )
2017
25
Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea. ( 28833893 )
2017
26
Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function. ( 29073797 )
2017
27
Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use. ( 29038072 )
2017
28
Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea. ( 28360449 )
2017
29
Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrhea. ( 28959377 )
2017
30
Risperidone-Induced Amenorrhea in Floridly Psychotic Female. ( 29152440 )
2017
31
Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency. ( 28485330 )
2017
32
Spectrum of MRI Appearance of Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome in Primary Amenorrhea Patients. ( 28893003 )
2017
33
Predictors of menstruation restoration during metformin administration for treatment of antipsychotic drug-induced amenorrhea: A post hoc analysis. ( 28292552 )
2017
34
Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. ( 28401076 )
2017
35
Primary Amenorrhea and Endometriosis Secondary to an Unusual MA1llerian Anomaly. ( 28461177 )
2017
36
A Case of Primary Amenorrhea with Swyer Syndrome. ( 29430160 )
2017
37
Amenorrhea after chemoembolization and suction curettage of caesarean scar pregnancy. ( 29303219 )
2017
38
Cytochrome P450 Oxidoreductase Deficiency: Novel Cause of Ambiguity with Primary Amenorrhea. ( 28459039 )
2017
39
Modulatory effects of l-carnitine plus l-acetyl-carnitine on neuroendocrine control of hypothalamic functions in functional hypothalamic amenorrhea (FHA). ( 28573875 )
2017
40
Amenorrhea during thalidomide treatment: An unusual cause of ovarian failure? ( 28396134 )
2017
41
Hypothalamic Amenorrhea and the Long-Term Health Consequences. ( 28658709 )
2017
42
The induction of ovulation by pulsatile administration of GnRH: an appropriate method in hypothalamic amenorrhea. ( 28277105 )
2017
43
Functional hypothalamic amenorrhea and its psychological correlates: a controlled comparison. ( 29517358 )
2017
44
Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea. ( 29243847 )
2017
45
Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea. ( 28500826 )
2017
46
Treatments to Prevent Bone Loss in Functional Hypothalamic Amenorrhea: A Systematic Review and Meta-Analysis. ( 29264505 )
2017
47
Secondary amenorrhea: Diagnostic approach and treatment considerations. ( 28832422 )
2017
48
Bone metabolism in anorexia nervosa and hypothalamic amenorrhea. ( 29107598 )
2017
49
Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome. ( 27089404 )
2016
50
Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA). ( 26634769 )
2016

Variations for Amenorrhea

ClinVar genetic disease variations for Amenorrhea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance GRCh37 Chromosome 2, 49295440: 49295440
2 FSHR NM_000145.3(FSHR): c.153-11T> A single nucleotide variant Uncertain significance GRCh38 Chromosome 2, 49068301: 49068301
3 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh38 Chromosome 2, 49154416: 49154416
4 FSHR NM_000145.3(FSHR): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs955385021 GRCh37 Chromosome 2, 49381555: 49381555

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CRH FSHB FSHR GNRH1 LEP LHB
2
Show member pathways
13.26 CRH FSHB FSHR GNRH1 LEP LHB
3
Show member pathways
12.85 FSHB FSHR LHB LHCGR NR5A1 POMC
4
Show member pathways
12.23 LEP LHB LHCGR PRL
5
Show member pathways
11.97 FSHB LEP LHB POMC
6 11.8 CRH FSHB FSHR LHB LHCGR POMC
7 11.05 FSHR LHCGR NR5A1
8 11.04 BMP15 FSHB FSHR LHB LHCGR
9
Show member pathways
10.97 LEP POMC TRH
10 10.89 FSHB FSHR
11 10.77 GNRH1 SHBG
12 10.28 CRH POMC
13 10.14 FSHB FSHR GNRH1 LHB LHCGR

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 BMP15 CRH FSHB GNRH1 LEP LHB
2 extracellular region GO:0005576 9.36 BMP15 CRH FSHB GNRH1 LEP LHB

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.88 FSHB GNRH1 LHB NR5A1 POMC TRH
2 response to ethanol GO:0045471 9.84 CRH GNRH1 LEP TRH
3 male gonad development GO:0008584 9.77 FSHR LHB LHCGR NR5A1 WNT4
4 peptide hormone processing GO:0016486 9.69 FSHB LHB POMC
5 female gamete generation GO:0007292 9.67 BMP15 FSHB FSHR
6 adrenal gland development GO:0030325 9.65 CRH NR5A1 WNT4
7 female pregnancy GO:0007565 9.65 CRH FSHB GNRH1 LEP PRL
8 positive regulation of JAK-STAT cascade GO:0046427 9.63 LEP PRL
9 uterus development GO:0060065 9.63 FSHR LHCGR
10 hormone metabolic process GO:0042445 9.63 LEP NR5A1 WNT4
11 response to corticosterone GO:0051412 9.62 CRH TRH
12 male sex determination GO:0030238 9.62 GNRH1 SRY
13 regulation of steroid biosynthetic process GO:0050810 9.61 LEP NR5A1
14 positive regulation of male gonad development GO:2000020 9.61 NR5A1 SRY
15 regulation of osteoclast differentiation GO:0045670 9.61 FSHB FSHR LHCGR
16 regulation of signaling receptor activity GO:0010469 9.61 BMP15 FSHB GNRH1 LEP LHB POMC
17 positive regulation of adenylate cyclase activity GO:0045762 9.6 FSHR LHCGR
18 Sertoli cell proliferation GO:0060011 9.59 FSHB FSHR
19 ovulation cycle process GO:0022602 9.58 FSHR LHCGR
20 progesterone biosynthetic process GO:0006701 9.58 FSHB LHB
21 primary ovarian follicle growth GO:0001545 9.56 FSHR LHCGR
22 negative regulation of glucagon secretion GO:0070093 9.55 CRH LEP
23 follicle-stimulating hormone signaling pathway GO:0042699 9.5 FSHB FSHR LHCGR
24 female gonad development GO:0008585 9.46 FSHR LHCGR NR5A1 WNT4
25 hormone-mediated signaling pathway GO:0009755 9.1 FSHB FSHR LHB LHCGR NR5A1 TRH
26 signal transduction GO:0007165 10.22 CRH FSHB FSHR GNRH1 LEP LHB
27 G-protein coupled receptor signaling pathway GO:0007186 10.13 CRH FSHB FSHR GNRH1 LHB LHCGR

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 CRH LEP LHB POMC WNT4
2 protein-hormone receptor activity GO:0016500 9.26 FSHR LHCGR
3 hormone activity GO:0005179 9.23 CRH FSHB GNRH1 LEP LHB POMC
4 follicle-stimulating hormone receptor activity GO:0004963 8.96 FSHR LHCGR

Sources for Amenorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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