Aliases & Classifications for Amenorrhea

MalaCards integrated aliases for Amenorrhea:

Name: Amenorrhea 12 74 6 43 15 17 71
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD9CM 34 626.0
MeSH 43 D000568
NCIt 49 C61443
SNOMED-CT 67 14302001
ICD10 32 N91.2
UMLS 71 C0002453

Summaries for Amenorrhea

Disease Ontology : 12 A female reproductive system disease that is characterized by the absence of menstruation.

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to hypogonadotropic hypogonadism 23 without anosmia and blepharophimosis, ptosis, and epicanthus inversus, and has symptoms including menometrorrhagia and ovulation bleeding. An important gene associated with Amenorrhea is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide ligand-binding receptors and DAG and IP3 signaling. The drugs Cyproterone Acetate and Desogestrel have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 74 Amenorrhea is the absence of a menstrual period in a woman of reproductive age. Physiological states of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 608)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 32.7 LHB GNRH1
2 blepharophimosis, ptosis, and epicanthus inversus 32.7 NR5A1 FOXL2 BMP15
3 kallmann syndrome 32.3 PRL NR5A1 LEP GNRH1 FSHR FSHB
4 galactorrhea 32.2 PRL IGF1
5 pituitary adenoma, prolactin-secreting 32.0 PRL POMC NR5A1 IGF1 GNRH1
6 hypogonadotropism 31.4 PRL GNRH1
7 anorexia nervosa 31.2 SHBG PRL POMC LEP INS IGF1
8 pituitary tumors 31.1 PRL POMC IGF1
9 adenoma 31.0 PRL POMC LHCGR IGF1
10 polycystic ovary syndrome 30.9 SHBG PRL POMC LEP INS IGF1
11 eating disorder 30.9 POMC LEP CRH
12 gonadal dysgenesis 30.9 SHBG NR5A1 GDF9 FSHR FOXL2 BMP15
13 ovarian cyst 30.7 PRL GNRH1 FOXL2
14 leydig cell tumor 30.6 PRL NR5A1 LHCGR GNRH1
15 46 xy gonadal dysgenesis 30.6 WNT4 SHBG NR5A1 FOXL2
16 pituitary adenoma 30.5 PRL POMC IGF1 GNRH1 CRH
17 chromophobe adenoma 30.5 PRL POMC
18 diabetes insipidus 30.4 PRL POMC INS CRH
19 hyperprolactinemia 30.4 SHBG PRL POMC INS IGF1 GNRH1
20 granulosa cell tumor of the ovary 30.4 PRL INS FOXL2
21 nonsyndromic disorders of testicular development 30.4 WNT4 NR5A1
22 pseudohermaphroditism 30.4 POMC NR5A1 LHCGR LHB FSHR
23 46,xx sex reversal 1 30.3 NR5A1 FSHR BMP15
24 spinocerebellar degeneration 30.3 PRL CRH
25 premature menopause 30.3 NOBOX GNRH1 GDF9 FSHR FOXL2 BMP15
26 craniopharyngioma 30.2 PRL NR5A1 INS IGF1 GNRH1
27 androgen insensitivity syndrome 30.2 SHBG NR5A1 INS
28 hermaphroditism 30.2 WNT4 SHBG NR5A1 FOXL2
29 46 xx gonadal dysgenesis 30.2 NR5A1 NOBOX LHCGR GDF9 FSHR FOXL2
30 infertility 30.2 SHBG PRL NR5A1 LHCGR LHB GNRH1
31 prolactin producing pituitary tumor 30.1 PRL POMC
32 turner syndrome 30.1 SHBG PRL LEP INS IGF1 BMP15
33 pseudohypoparathyroidism 30.0 PRL LEP IGF1
34 adrenal adenoma 30.0 POMC INS CRH
35 premenstrual tension 30.0 POMC GNRH1
36 hypoglycemia 29.9 PRL POMC INS IGF1 CRH
37 hypoadrenocorticism, familial 29.9 POMC NR5A1 CRH
38 secondary adrenal insufficiency 29.9 INS IGF1
39 hypogonadism 29.9 SHBG PRL LHCGR LHB LEP INS
40 hypokalemia 29.9 POMC INS CRH
41 osteoporosis 29.9 SHBG PRL LEP INS IGF1 GNRH1
42 empty sella syndrome 29.9 PRL POMC INS IGF1 GNRH1
43 hypogonadotropic hypogonadism 29.8 SHBG PRL NR5A1 LHCGR LHB LEP
44 hypoadrenalism 29.8 SHBG POMC CRH
45 sleep apnea 29.8 LEP INS IGF1
46 neurofibromatosis, type ii 29.8 SHBG PRL POMC INS IGF1
47 estrogen excess 29.8 SHBG PRL GNRH1 FSHR FOXL2
48 acanthosis nigricans 29.8 SHBG PRL LEP INS IGF1
49 carney complex variant 29.8 PRL POMC IGF1
50 intracranial hypertension, idiopathic 29.8 POMC LEP IGF1

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


menometrorrhagia, ovulation bleeding

MGI Mouse Phenotypes related to Amenorrhea:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.41 BMP15 CRH FOXL2 FSHB FSHR GDF9
2 homeostasis/metabolism MP:0005376 10.34 CRH ERCC6 FOXL2 FSHB FSHR GDF9
3 cellular MP:0005384 10.27 CRH ERCC6 FSHB FSHR IGF1 INS
4 growth/size/body region MP:0005378 10.27 CRH ERCC6 FOXL2 FSHR GNRH1 IGF1
5 immune system MP:0005387 10.14 CRH ERCC6 FSHR GNRH1 IGF1 INS
6 adipose tissue MP:0005375 10.11 CRH ERCC6 FSHR IGF1 INS LEP
7 integument MP:0010771 10.07 CRH ERCC6 FSHR GNRH1 IGF1 INS
8 nervous system MP:0003631 9.93 CRH ERCC6 FSHR GNRH1 IGF1 INS
9 liver/biliary system MP:0005370 9.92 CRH ERCC6 GNRH1 INS LEP LHCGR
10 neoplasm MP:0002006 9.8 ERCC6 FSHR GNRH1 IGF1 LEP POMC
11 renal/urinary system MP:0005367 9.56 CRH GNRH1 IGF1 INS LEP LHCGR
12 reproductive system MP:0005389 9.5 BMP15 FOXL2 FSHB FSHR GDF9 GNRH1

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 314)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
2
Desogestrel Approved Phase 4 54024-22-5 40973
3
Sodium citrate Approved, Investigational Phase 4 68-04-2
4
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
5
Nicotine Approved Phase 4 54-11-5 942 89594
6
Metformin Approved Phase 4 657-24-9 14219 4091
7
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
8
Copper Approved, Investigational Phase 4 7440-50-8 27099
9
Tibolone Approved, Investigational Phase 4 5630-53-5
10
Calcium carbonate Approved, Investigational Phase 4 471-34-1
11
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
12
Sargramostim Approved, Investigational Phase 4 123774-72-1, 83869-56-1
13
Lenograstim Approved, Investigational Phase 4 135968-09-1
14
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
15
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
16
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
17
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
18
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
19
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
20
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
21
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
22
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
23
Enclomiphene Investigational Phase 4 15690-57-0
24
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
25
Cyproterone Phase 4 2098-66-0 5284537
26 Mitogens Phase 4
27 Tin Fluorides Phase 4
28 Dacuronium Phase 4
29 Estrogens, Conjugated (USP) Phase 4
30 Zuclomiphene Phase 4
31 Citrate Phase 4
32 Anticoagulants Phase 4
33 Chelating Agents Phase 4
34 Clomiphene Phase 4
35 Autonomic Agents Phase 4
36 Fenugreek seed meal Phase 4
37 Fenugreek Phase 4
38 Vitamin B 6 Phase 4
39 Hydroxycholecalciferols Phase 4
40 Ibandronic Acid Phase 4
41 Central Nervous System Stimulants Phase 4
42 Cholinergic Agents Phase 4
43 Nicotinic Agonists Phase 4
44 Liver Extracts Phase 4
45 Anti-Infective Agents Phase 4
46 Anti-Retroviral Agents Phase 4
47 Antiviral Agents Phase 4
48 Reverse Transcriptase Inhibitors Phase 4
49 Progestins Phase 4
50 Fertility Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 285)
# Name Status NCT ID Phase Drugs
1 Phase IV Study of the Use of Two Preparations of Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation of Hyper-androgenic Origin Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
2 Multicenter Randomized Clinical Trial to Evaluate the Safety and Effectiveness of Cavaterm TM Thermal Balloon Endometrial Ablation in Women With Dysfunctional Uterine Bleeding Compared to Transcervical Resection of the Endometrium (TCRE) Unknown status NCT00549159 Phase 4
3 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
4 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Unknown status NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients. Unknown status NCT01246310 Phase 4
6 The Effect of UPA on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
7 The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS). Unknown status NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
8 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Unknown status NCT02601196 Phase 4 Ulipristal acetate
9 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients: a Double Blind, Placebo-controlled Study Completed NCT01206153 Phase 4 metformin
10 Evaluation of Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion of Endometrium and Withdrawal Bleeding in Subjects With Secondary Amenorrhea Completed NCT00160199 Phase 4 PROMETRIUM® 300 mg;PROMETRIUM® 400 mg
11 Effect of Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding Continuation, Contraceptive Continuation, and Postpartum Depression: a Randomized Trial Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
12 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
13 Is Endometrial Withdrawal Bleeding Necessary Prior to Ovulation Induction With Clomiphene Citrate? A Randomized Controlled Trial and Feasibility Study Completed NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
14 Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial Completed NCT03221816 Phase 4 Tenavit®;Placebo Oral Tablet
15 Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus-Prevalence,Risk Factors and Treatment Completed NCT00668330 Phase 4 Ibandronate+alfacalcidol+calcium;placebo ibandronate+alfacalcidol+calcium
16 Progesterone Augmentation of Nicotine Replacement Therapy Study Completed NCT02685072 Phase 4 Progesterone (200 mgs BID);Placebo
17 Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome Completed NCT02789488 Phase 4
18 Effect Of Hormone Replacement Therapy On Disease Activity, Menopausal Symptoms And Bone Mineral Density In Peri/Postmenopausal Women With Systemic Lupus Erythematosus.Randomized Clinical Trial Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
19 A Randomized Controlled Trial to Compare the Menstrual Bleeding Profile Among Copper and 13,5mg Levonorgestrel-releasing IUD Users. Recruiting NCT02957292 Phase 4 Levonorgestrel (13,5 mg) intrauterine device
20 Body Composition and Metabolic Manifestations of Insulin Resistance in Adolescents With Polycystic Ovary Syndrome: Ectopic Fat Deposition and Metabolic Markers: Intervention and Follow-up Portion Recruiting NCT02500147 Phase 4 Metformin;Placebo
21 A Randomized Controlled Trial of Vaginal Estrogen to Treat Asymptomatic Microscopic Hematuria Recruiting NCT03033160 Phase 4 Estradiol Ring
22 Impact of Concurrent Initiation of DMPA Contraception and Tenofovir PrEP on Bone Loss in Young Women Recruiting NCT03464266 Phase 4 FTC/TDF;DMPA
23 A Randomized Controlled Trial of Pre-retrieval Triggering Methods in in Vitro Fertilization Patients Classified as Low, Normal or High Responder Recruiting NCT02715336 Phase 4 Ovulation induction with hCG and Lupron (GnRH agonist)
24 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Active, not recruiting NCT02937779 Phase 4 Tenofovir disoproxil fumarate
25 The Effect of Estrogen in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
26 Psychological Impact of Amenorrhea in Women With Endometriosis: Perspective Randomized Study Not yet recruiting NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
27 CLASSICAL ANTAGONIST PROTOCOL IN COMPARISON WITH AGONIST STOP PROTOCOL IN Polycystic Ovary Symdrome WOMEN UNDERGOING Intra-cytoplasmic Injection TRIAL: a Randomized Controlled Trial Not yet recruiting NCT04094467 Phase 4 Cetrorelix;Leuprolide Acetate
28 Autologous Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure Patients. Pilot Study ASCOT-2 Not yet recruiting NCT03535480 Phase 4 G-CSF
29 The Luveris® In Vitro Fertilization Trial: The Effect of Recombinant Luteinizing Hormone on Follicular Response, Oocyte Quality, and Pregnancy in In-Vitro Fertilization Treatment Cycles in Women Without Endogenous LH Activity. Terminated NCT00889512 Phase 4 Luveris fixed dose;Luveris increasing dose
30 Randomized, Open Label, 8-Week Study of Quetiapine and Risperidone on Quality of Life in Female With Schizophrenia Terminated NCT00498004 Phase 4 Quetiapine, Risperidone
31 Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy in Open, Multicenter Phase IV Clinical Studies Terminated NCT03210324 Phase 4 Mifepristone tablets
32 Hydroxyzine Effects on Meal-Related Anxiety in Underweight Adolescents and Young Adults Diagnosed With an Eating Disorder - A Pilot Study Withdrawn NCT01372670 Phase 4 Hydroxyzine;hydroxyzine HCL
33 Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Withdrawn NCT03325868 Phase 4 Ulipristal Acetate
34 Use of the GnRH Agonist Leuprolide Acetate (Lupron(Registered Trademark)) to Preserve Ovarian Function in Women Undergoing Chemotherapy Withdrawn NCT00507780 Phase 4 GnRH antagonist
35 Prospective Experimental of Tripterygium Glycoside in the Treatment of Crohn's Disease for Induction Remission Unknown status NCT02044952 Phase 2, Phase 3 Mesalazine, Tripterygium glycosides
36 A Randomized Phase III Trial Comparing Nanoparticle-based Paclitaxel With Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Patients With Early Breast Cancer (GeparSepto) Unknown status NCT01583426 Phase 3 nab-Paclitaxel;Paclitaxel
37 Phase 3 Study Investigating the Effect of Endobarrier Treatment on Fertility in Women With Polycystic Ovary Syndrome Unknown status NCT02255578 Phase 3 clomiphene citrate treatment
38 A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study Evaluating Three Doses of Subcutaneous Pulsatile GnRH Administered Via OmniPod Pump for Ovulation Induction in Female Subjects With Primary Amenorrhea With Hypogonadotropic Hypogonadism Completed NCT01976728 Phase 3 Gonadorelin acetate subcutaneous (SC) 10 μg/pulse as a fixed dose, administered via. OmniPod pump;Gonadorelin acetate SC 15 μg/pulse as a fixed dose, administered via. OmniPod pump;Gonadorelin acetate SC 20 μg/pulse as a fixed dose, administered via. OmniPod pump;Placebo (SC 10, 15, or 20 μg/pulse as a fixed dose, administered via. OmniPod pump)
39 A Clinical Trial Of Adjuvant Therapy Comparing Six Cycles Of 5-Fluorouracil, Epirubicin And Cyclophosphamide (FEC) To Four Cycles Of Adriamycin And Cyclophosphamide (AC) In Patients With Node-Negative Breast Cancer Completed NCT00087178 Phase 3 cyclophosphamide;adriamycin;epirubicin;fluorouracil
40 Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women Completed NCT02224313 Phase 3 oral estradiol 1.0 mg;oral progesterone 100 mg
41 Mifepristone Versus Placebo to Treat Adenomyosis: a Double-blind, Multicentre,Randomized Clinical Trial Completed NCT03520439 Phase 2, Phase 3 Mifepristone;Placebo
42 A Double Blind Randomized Controlled Trial to Study the Effectiveness of a Levonorgestrel Releasing Intrauterine Device for the Treatment of Pelvic Pain or Dysmenorrhea in the Patients Undergone Conservative Surgery for Pelvic Endometriosis Completed NCT00455845 Phase 3
43 Parallel-Group Comparative Study of SJ-0021 and Purified Pituitary Gonadotropin in Subjects With Amenorrhea I or Anovulatory Cycles - Phase III Single-Blind Study Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
44 A Randomized, Placebo Controlled Trial Of Zoledronic Acid For The Prevention Of Bone Loss In Premenopausal Women With Early Stage Breast Cancer Completed NCT00049452 Phase 3 zoledronic acid
45 Feasibility Study of the Measurement of the Placental Perfusion During the First Trimester of Pregnancy by 3D Doppler Echo-angiography With a Contrast Agent Completed NCT02884297 Phase 3 Contrast agent: SonoVue®.
46 Effects of Anorexia Nervosa on Peak Bone Mass Completed NCT00088153 Phase 2, Phase 3 Physiologic Estrogen/progesterone
47 A Three-Arm Randomized Trial to Compare Adjuvant Adriamycin and Cyclophosphamide Followed by Taxotere (AC-T); Adriamycin and Taxotere (AT); and Adriamycin, Taxotere, and Cyclophosphamide (ATC) in Breast Cancer Patients With Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3 cyclophosphamide;docetaxel;doxorubicin
48 Antenatal Multiple Micronutrient Supplementation to Improve Infant Survival and Health in Bangladesh Completed NCT00860470 Phase 3
49 Effects of Metformin on Fertility and Pregnancy in Women With Polycystic Ovary Syndrome: a Randomized, Prospective, Placebo-controlled Multicenter Study Completed NCT00994812 Phase 3 metformin
50 Six Month, Double Blind, Placebo-controlled Trial of the Efficacy of Raloxifene as an Adjuvant Treatment of the Negative Symptoms of Schizophrenia in Post-menopausal Women Completed NCT01573637 Phase 3 Raloxifene;Lactosa (placebo arm)

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 71 / NDF-RT 50 :


17-alpha-Hydroxyprogesterone
2-Bromoergocryptine Mesylate
Bromocriptine
Gonadorelin
Gonadorelin Acetate
Gonadorelin Hydrochloride
hydroxyprogesterone caproate (USP)
Medroxyprogesterone
medroxyprogesterone acetate
norelgestromin
Norethynodrel
norgestimate
Progesterone
PROGESTERONE PWDR

Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

40
Pituitary, Bone, Ovary, Breast, Testes, Thyroid, Uterus

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 9778)
# Title Authors PMID Year
1
Midlife women's health consequences associated with polycystic ovary syndrome. 61
31657237 2020
2
Traditional Medicine (Mahuang-Tang) Improves Ovarian Dysfunction and the Regulation of Steroidogenic Genes in Letrozole-Induced PCOS Rats. 61
31606536 2020
3
Pathology of prolactinomas: any predictive value? 61
31641970 2020
4
Disorder of sex development with germ cell tumors: Which is uncovered first? 61
32020769 2020
5
Bone density status in a large population of patients with anorexia nervosa. 61
31765843 2020
6
Novel FSHR variants causing female resistant ovary syndrome. 61
31830376 2020
7
[Late preterm : high risk newborns despite appearances]. 61
32030935 2020
8
Premature ovarian insufficiency - novel hormonal approaches in optimizing fertility. 61
31311350 2020
9
Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial. 61
31603998 2020
10
Depo-medroxyprogesterone acetate, weight gain and amenorrhea among obese adolescent and adult women. 61
31928370 2020
11
Women With Amenorrhea and Men With Menstruation: The Qualitative Experiences of People With Disorders of Sex Development in Nigeria. 61
30855517 2020
12
Ovarian vein sampling, and serum and urine testosterone monitoring in ovarian Leydig cell tumors: A report of two cases. 61
31908972 2020
13
Successful laparoscopic resection of virilizing ovarian steroid cell tumor, not otherwise specified, in a 22-year-old woman: a case report and evaluation of the steroidogenic pathway. 61
31827013 2020
14
Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives. 61
31955275 2020
15
Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double-blind, randomized, phase II dose-finding study. 61
31956287 2020
16
Depression After ACS, Amenorrhea, Physical Activity, Heart Failure, Erythema Multiforme. 61
31939637 2020
17
Endometrial safety and bleeding profile of a 17β-estradiol/progesterone oral softgel capsule (TX-001HR). 61
31913228 2020
18
OUTPATIENT ANALYTIC ASSESSMENT OF ANOREXIA NERVOSA - THE IMPORTANCE OF VENOUS BLOOD GASES. 61
31939517 2020
19
A report of congenital adrenal hyperplasia due to 17α-hydroxylase deficiency in two 46,XX sisters. 61
31464148 2020
20
Mayer-Rokitansky-Küster-Hauser syndrome - case studies, methods of treatment and the future prospects of human uterus transplantation. 61
32016956 2020
21
Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1. 61
31952842 2020
22
Physical health and symptoms of relative energy deficiency in female fitness athletes. 61
31593622 2020
23
Ovarian dysgerminoma with Müllerian anomaly: a case report. 61
31970134 2020
24
Placental site trophoblastic disease. 61
31699803 2020
25
Ovarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: a multicenter retrospective cohort study. 61
31996163 2020
26
Ulipristal Acetate Prior to Surgery for Endometriosis. 61
32006245 2020
27
Antipsychotic Treatment effectiveness in First Episode of Psychosis: PAFIP 3-year follow-up randomized clinical trials comparing haloperidol, olanzapine, risperidone, aripiprazole, quetiapine and ziprasidone. 61
31974576 2020
28
Primary Ovarian Insufficiency Nationwide Incidence Rate and Etiology Among Israeli Adolescents. 61
31987720 2020
29
Asherman syndrome and insufficient endometrial thickness: A hypothesis of integrated approach to restore the endometrium. 61
31887722 2020
30
Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency. 61
31957178 2020
31
Anti-Mullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation. 61
31965189 2020
32
Endometrial ablation or resection versus levonorgestrel intra-uterine system for the treatment of women with heavy menstrual bleeding and a normal uterine cavity: a systematic review with meta-analysis. 61
31990359 2020
33
Factors That Impact Fertility after Hysteroscopic Adhesiolysis for Intrauterine Adhesions and Amenorrhea: A Retrospective Cohort Study. 61
30880159 2020
34
Use of the progestin challenge test in diagnosing amenorrhea: the time has come to say goodbye. 61
32033722 2020
35
Prolonged Amenorrhea and Low Hip Bone Mineral Density in Women Living with HIV-a Controlled, Cross-Sectional Study. 61
31914005 2020
36
Pregnancy after mumps: a case report. 61
31864420 2019
37
Primary ovarian insufficiency associated with pazopanib therapy in a breast angiosarcoma patient: A CARE-compliant case report. 61
31852067 2019
38
Association Between Pelvic Floor Muscle Strength and Sexual Function in Postmenopausal Women. 61
31680007 2019
39
Discriminating hypothalamic oligomenorrhea/amenorrhea from hyperandrogenic oligomenorrhea/amenorrhea in exercising women. 61
31815525 2019
40
Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand? 61
31838714 2019
41
Acupuncture and Chinese Herbal Medicine Effects on Assisted Reproductive Technology: Six Cases and Their Clinical Significance. 61
31871529 2019
42
Kallmann Syndrome with Syndactyly. 61
31779756 2019
43
Misdiagnosis of Mullerian agenesis in a patient with 46, XX gonadal dysgenesis: a missed opportunity for prevention of osteoporosis. 61
31809259 2019
44
Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy. 61
31897335 2019
45
[Endocrine adjuvant treatment specific features for young breast cancer women]. 61
32008734 2019
46
Safety and efficacy of autologous hematopoietic stem cell transplantation for multiple sclerosis in Norway. 61
31833798 2019
47
Risk factors for failed induction of labor among pregnant women with Class III obesity. 61
31863451 2019
48
Chronic Sheehan's Syndrome - A Differential to be Considered in Clinical Practice in Women with a History of Postpartum Hemorrhage. 61
31938584 2019
49
A rare cause of delayed puberty in two cases with 46,XX and 46,XY karyotype: 17 α-hydroxylase deficiency due to a novel variant in CYP17A1 gene. 61
31885295 2019
50
Turner syndrome and Cushing disease - the coexistence with overlapping complications: case report and literature review. 61
31242778 2019

Variations for Amenorrhea

ClinVar genetic disease variations for Amenorrhea:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FSHR NM_000145.3(FSHR):c.2T>C (p.Met1Thr)SNV Pathogenic 523337 rs955385021 2:49381555-49381555 2:49154416-49154416
2 FSHR NM_000145.3(FSHR):c.153-11T>ASNV Uncertain significance 523336 rs1553340669 2:49295440-49295440 2:49068301-49068301

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 WNT4 PRL POMC LHCGR LHB LEP
2
Show member pathways
12.9 POMC NR5A1 LHCGR LHB FSHR FSHB
3
Show member pathways
12.7 WNT4 POMC NR5A1 INS CRH
4
Show member pathways
12.31 PRL LHCGR LHB LEP INS
5 12.17 POMC LHCGR LHB FSHR FSHB
6
Show member pathways
12.06 POMC LHB LEP INS IGF1 FSHB
7 11.8 POMC LHCGR LHB FSHR FSHB CRH
8 11.35 PRL LEP INS
9 11.17 NR5A1 LHCGR GDF9 FSHR
10 10.86 PRL POMC LEP INS
11 10.86 LHCGR LHB INS IGF1 FSHR FSHB
12 10.83 LHB IGF1 GNRH1 GDF9 BMP15
13 10.47 LHCGR LHB GNRH1 FSHR FSHB
14 10.34 POMC CRH

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 WNT4 SHBG PRL POMC LHB LEP
2 extracellular space GO:0005615 9.4 WNT4 PRL POMC LHB LEP INS
3 Golgi lumen GO:0005796 9.33 WNT4 LHB INS

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.11 POMC LHCGR LHB INS GNRH1 FSHR
2 signal transduction GO:0007165 10.11 PRL POMC LHCGR LHB LEP INS
3 positive regulation of gene expression GO:0010628 9.97 NR5A1 INS IGF1 FSHB ERCC6 CRH
4 positive regulation of cell proliferation GO:0008284 9.95 PRL LEP INS IGF1 GDF9 FSHB
5 cellular protein metabolic process GO:0044267 9.92 PRL INS IGF1 BMP15
6 cell-cell signaling GO:0007267 9.92 POMC LHB INS GNRH1
7 regulation of MAPK cascade GO:0043408 9.78 GDF9 FSHR BMP15
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 LEP INS IGF1 FSHR
9 male gonad development GO:0008584 9.72 WNT4 NR5A1 LHCGR LHB FSHR
10 adrenal gland development GO:0030325 9.65 WNT4 NR5A1 CRH
11 female pregnancy GO:0007565 9.65 PRL LEP GNRH1 FSHB CRH
12 regulation of osteoclast differentiation GO:0045670 9.63 FSHR FSHB
13 male sex determination GO:0030238 9.63 NR5A1 GNRH1
14 regulation of steroid biosynthetic process GO:0050810 9.61 NR5A1 LEP
15 hormone metabolic process GO:0042445 9.61 WNT4 NR5A1 LEP
16 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.6 LEP FOXL2
17 bone mineralization involved in bone maturation GO:0035630 9.59 LEP IGF1
18 Sertoli cell proliferation GO:0060011 9.58 FSHR FSHB
19 ovulation cycle process GO:0022602 9.58 LHCGR FSHR
20 negative regulation of glucagon secretion GO:0070093 9.57 LEP CRH
21 follicle-stimulating hormone signaling pathway GO:0042699 9.56 FSHR FSHB
22 positive regulation of luteinizing hormone secretion GO:0033686 9.55 LEP FOXL2
23 progesterone biosynthetic process GO:0006701 9.54 LHB FSHB
24 oocyte growth GO:0001555 9.52 GDF9 FOXL2
25 female gonad development GO:0008585 9.46 WNT4 NR5A1 FSHR FOXL2
26 female gamete generation GO:0007292 9.26 GDF9 FSHR FSHB BMP15
27 hormone-mediated signaling pathway GO:0009755 9.02 NR5A1 LHCGR LHB FSHR FSHB

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 WNT4 POMC LHB LEP CRH
2 hormone activity GO:0005179 9.28 PRL POMC LHB LEP INS IGF1
3 insulin-like growth factor receptor binding GO:0005159 9.26 INS IGF1
4 protein-hormone receptor activity GO:0016500 9.16 LHCGR FSHR

Sources for Amenorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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