MCID: AMR001
MIFTS: 25

American Histoplasmosis

Categories: Infectious diseases

Aliases & Classifications for American Histoplasmosis

MalaCards integrated aliases for American Histoplasmosis:

Name: American Histoplasmosis 12 15
Infection by Histoplasma Capsulatum 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1759
ICD9CM 34 115.0
MeSH 43 D006660
SNOMED-CT 67 76255006
ICD10 32 B39.4
UMLS 71 C0153261

Summaries for American Histoplasmosis

Disease Ontology : 12 A histoplasmosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

MalaCards based summary : American Histoplasmosis, also known as infection by histoplasma capsulatum, is related to histoplasmosis and choroiditis. An important gene associated with American Histoplasmosis is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. Affiliated tissues include heart, colon and liver.

Related Diseases for American Histoplasmosis

Diseases related to American Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 histoplasmosis 30.1 CD40LG CD4
2 choroiditis 29.5 CD40LG CD4
3 polyradiculopathy 10.2 CD40LG AKR1B1
4 lipoid nephrosis 10.1 CD40LG CD2AP
5 retroperitoneal lymphoma 10.1 TNFRSF8 CD40LG
6 intermittent claudication 10.0 LPL CD40LG
7 marginal zone b-cell lymphoma 9.9 TNFRSF8 CD40LG
8 cork-handlers' disease 9.9 CD40LG CD4
9 syphilitic meningitis 9.9 CD40LG CD4
10 early yaws 9.9 CD40LG CD4
11 asymptomatic neurosyphilis 9.9 CD40LG CD4
12 syphilis 9.9 CD40LG CD4
13 latent syphilis 9.9 CD40LG CD4
14 gastroduodenitis 9.9 CD40LG CD4
15 duodenitis 9.9 CD40LG CD4
16 primary syphilis 9.9 CD40LG CD4
17 transient arthritis 9.9 CD40LG CD4
18 norwegian scabies 9.9 CD40LG CD4
19 necrotizing ulcerative gingivitis 9.9 CD40LG CD4
20 neuroretinitis 9.9 CD40LG CD4
21 tertiary neurosyphilis 9.9 CD40LG CD4
22 bacillary angiomatosis 9.9 CD40LG CD4
23 meningovascular neurosyphilis 9.9 CD40LG CD4
24 viral exanthem 9.9 CD40LG CD4
25 exanthem 9.9 CD40LG CD4
26 tertiary syphilis 9.9 CD40LG CD4
27 acute retinal necrosis syndrome 9.9 CD40LG CD4
28 optic papillitis 9.9 CD40LG CD4
29 opportunistic bacterial infectious disease 9.9 CD40LG CD4
30 gastrointestinal tuberculosis 9.9 CD40LG CD4
31 cerebritis 9.9 CD40LG CD4
32 granulomatous hepatitis 9.9 CD40LG CD4
33 exanthema subitum 9.9 CD40LG CD4
34 west nile encephalitis 9.9 CD40LG CD4
35 mikulicz disease 9.9 CD40LG CD4
36 autoimmune peripheral neuropathy 9.9 CD40LG CD4
37 congenital syphilis 9.9 CD40LG CD4
38 trichinosis 9.9 CD40LG CD4
39 mononeuritis of upper limb and mononeuritis multiplex 9.9 CD40LG CD4
40 mononeuritis multiplex 9.9 CD40LG CD4
41 granulomatous dermatitis 9.9 CD40LG CD4
42 secondary syphilis 9.9 CD40LG CD4
43 chancroid 9.9 CD40LG CD4
44 parotid disease 9.9 CD40LG CD4
45 aortitis 9.9 CD40LG CD4
46 west nile fever 9.9 CD40LG CD4
47 splenic sequestration 9.9 CD40LG CD4
48 mastoiditis 9.9 CD40LG CD4
49 abdominal tuberculosis 9.9 CD40LG CD4
50 paralytic poliomyelitis 9.9 CD40LG CD4

Graphical network of the top 20 diseases related to American Histoplasmosis:



Diseases related to American Histoplasmosis

Symptoms & Phenotypes for American Histoplasmosis

Drugs & Therapeutics for American Histoplasmosis

Search Clinical Trials , NIH Clinical Center for American Histoplasmosis

Genetic Tests for American Histoplasmosis

Anatomical Context for American Histoplasmosis

MalaCards organs/tissues related to American Histoplasmosis:

40
Heart, Colon, Liver, T Cells, Tongue

Publications for American Histoplasmosis

Articles related to American Histoplasmosis:

(show all 38)
# Title Authors PMID Year
1
Colonic Infection by Histoplasma capsulatum in a Liver Transplant Patient: A Case Report. 61
32197866 2020
2
African histoplasmosis in a Guinea Bissau patient with HIV-2: Case report and review. 61
31706701 2020
3
Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult. 61
31989393 2020
4
Identifying molecularly defined antigens for a Histoplasma capsulatum-specific interferon gamma release assay. 61
31757594 2019
5
Novel clinical and dual infection by Histoplasma capsulatum genotypes in HIV patients from Northeastern, Brazil. 61
31409874 2019
6
Mixed infection by Histoplasma capsulatum isolates with different mating types in Brazilian AIDS-patients. 61
30785562 2019
7
Infection by Histoplasma capsulatum, Cryptococcus spp. and Paracoccidioides brasiliensis in bats collected in urban areas. 61
30296014 2018
8
Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature. 61
30477434 2018
9
Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients. 61
29429549 2018
10
Systemic fungal infection by Histoplasma capsulatum: intracellular fungus in peripheral leukocytes. 61
26969780 2016
11
[American histoplasmosis: clinicopathological features in immunocompetent and immunocompromised patients. A report of two cases of infection by Histoplasma capsulatum on Reunion Island]. 61
24878163 2014
12
Histoplasmosis mimicking adrenal carcinoma. 61
24600775 2014
13
Histoplasmosis in immunocompetent individuals living in an endemic area in the Brazilian Southeast. 61
23982099 2013
14
A rare cause of an ileocecal fistula in an AIDS patient. Gastrointestinal infection by Histoplasma capsulatum infection identified with internal transcribed spacer primer sets. 61
23499285 2013
15
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum. 61
23455499 2013
16
Histoplasmosis as cause of penile ulcer in acquired immune deficiency syndrome (AIDS): three case reports. 61
17934793 2007
17
Histoplasmosis as a cause of nodular myositis in an AIDS patient diagnosed on fine needle aspiration cytology. A case report. 61
17328504 2007
18
American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis. 61
16940867 2006
19
[Pseudotumoral presentation of American pulmonary histioplasmosis]. 61
16449925 2005
20
Molecular detection of Cellulosimicrobium cellulans as the etiological agent of a chronic tongue ulcer in a human immunodeficiency virus-positive patient. 61
16081997 2005
21
Histoplasmosis of the larynx. 61
16379201 2005
22
Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. 61
15879127 2005
23
An outbreak of acute pulmonary histoplasmosis in members of a trekking trip in Martinique, French West Indies. 61
12650650 2003
24
[American histoplasmosis: a case with cutaneous presentation in Morocco]. 61
12910657 2003
25
[Disseminated infection by Histoplasma capsulatum with AIDS]. 61
11490941 2001
26
[Papular exanthema in systemic histoplasmosis and HIV infection]. 61
9715388 1998
27
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. 61
8799429 1996
28
Antifungal mechanisms of activated murine bronchoalveolar or peritoneal macrophages for Histoplasma capsulatum. 61
7554402 1995
29
Opportunistic invasion of the heart in Hispanic patients with acquired immunodeficiency syndrome. 61
8059916 1994
30
Histoplasma capsulatum peritonitis associated with continuous ambulatory peritoneal dialysis. 61
8326997 1993
31
Mediastinal fibrosis complicating histoplasmosis. 61
3045478 1988
32
[Histoplasmosis]. 61
3773679 1986
33
[Multifocal inner choroiditis: pseudohistoplasmosis. The European form of the presumed American histoplasmosis]. 61
2434554 1986
34
[Disseminated form of histoplasmosis caused by Histoplasma capsulatum in a Zairian child]. 61
6296597 1982
35
[Reflections on African and American histoplasmosis (author's transl)]. 61
7088027 1982
36
[Digestive disorders in histoplasmosis. Report of a case of ulcerous enterocolitis caused by Histoplasma capsulatum (author's transl)]. 61
6972477 1981
37
[A case of disseminated histoplasmosis due to Histoplasma capsulatum (author's transl)]. 61
7396328 1980
38
[American histoplasmosis developing for 56 years]. 61
4603329 1974

Variations for American Histoplasmosis

Expression for American Histoplasmosis

Search GEO for disease gene expression data for American Histoplasmosis.

Pathways for American Histoplasmosis

Pathways related to American Histoplasmosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 TNFRSF8 CD40LG CD2AP
2
Show member pathways
11.12 TNFRSF8 CD40LG
3 10.94 LPL AKR1B1
4 10.2 CD40LG CD4

GO Terms for American Histoplasmosis

Biological processes related to American Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 8.96 CD40LG CD4
2 retinoid metabolic process GO:0001523 8.62 LPL AKR1B1

Sources for American Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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