MCID: AMT001
MIFTS: 27

Ametropic Amblyopia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Ametropic Amblyopia

MalaCards integrated aliases for Ametropic Amblyopia:

Name: Ametropic Amblyopia 12 15
Refractive Amblyopia 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10377
ICD9CM 34 368.03
SNOMED-CT 67 90927000
ICD10 32 H53.02
UMLS 71 C0152190

Summaries for Ametropic Amblyopia

MalaCards based summary : Ametropic Amblyopia, also known as refractive amblyopia, is related to amblyopia and astigmatism. An important gene associated with Ametropic Amblyopia is DSE (Dermatan Sulfate Epimerase). The drugs Mydriatics and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain.

Wikipedia : 74 Ametropic amblyopia, is a medical condition in which the retina cannot focus on the image of a distant... more...

Related Diseases for Ametropic Amblyopia

Diseases related to Ametropic Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 amblyopia 31.1 PHOX2A DSE CYLC1
2 astigmatism 30.4 NBL1 DSE CYLC1
3 anisometropia 30.3 NBL1 DSE CYLC1
4 esotropia 30.2 PHOX2A DSE CYLC1
5 exotropia 30.0 PHOX2A CYLC1
6 cycloplegia 30.0 NBL1 DSE CYLC1
7 suppression amblyopia 30.0 PHOX2A NBL1 MTRNR2L5 MTRNR2L4 DSE
8 strabismus 29.9 PHOX2A DSE CYLC1
9 pathologic nystagmus 29.4 NYX LCA5
10 farsightedness 10.4
11 joint laxity, short stature, and myopia 10.3
12 cornea plana 10.3
13 nanophthalmos 10.3
14 monocular esotropia 10.3
15 microphthalmia 10.3
16 myopia 10.3
17 mechanical strabismus 10.3
18 refractive error 10.3
19 ocular motor apraxia 10.1
20 disuse amblyopia 10.1
21 alternating exotropia 10.1
22 accommodative esotropia 10.1
23 eye accommodation disease 9.9 NBL1 DSE CYLC1
24 paralytic squint 9.9 PHOX2A MTRNR2L5
25 facial nerve disease 9.8 MTRNR2L5 MTRNR2L4
26 facial paralysis 9.8 MTRNR2L5 MTRNR2L4

Graphical network of the top 20 diseases related to Ametropic Amblyopia:



Diseases related to Ametropic Amblyopia

Symptoms & Phenotypes for Ametropic Amblyopia

Drugs & Therapeutics for Ametropic Amblyopia

Drugs for Ametropic Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mydriatics Phase 2
2
Methamphetamine Approved, Illicit 537-46-2 10836
3
Dopamine Approved 51-61-6, 62-31-7 681
4 Central Nervous System Stimulants
5 Adrenergic Agents
6 Sympathomimetics
7 Neurotransmitter Agents
8 Dopamine Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
2 Bilateral Refractive Amblyopia Treatment Study Completed NCT00305955
3 Stochastic Resonance Applied to Amblyopia Training and the Plasticity of Brain Completed NCT04213066
4 Detection of Hyperopia by Photoscreener GoCheckKids With Glow Fixation Device Completed NCT04297969
5 Disinvestment Study of Population-Based Vision Screening in Preverbal Children in the Netherlands Completed NCT01675193
6 Objective Adherence With Optical Correction in Children With Bilateral and Unilateral Refractive Amblyopia Recruiting NCT03780205
7 Photorefractive Keratectomy for Anisometropic and Isoametropic Amblyopia in Children Refractory to Conventional Treatment Active, not recruiting NCT03610997

Search NIH Clinical Center for Ametropic Amblyopia

Genetic Tests for Ametropic Amblyopia

Anatomical Context for Ametropic Amblyopia

MalaCards organs/tissues related to Ametropic Amblyopia:

40
Eye, Retina, Brain, Cortex

Publications for Ametropic Amblyopia

Articles related to Ametropic Amblyopia:

(show top 50) (show all 131)
# Title Authors PMID Year
1
Saccadic reaction time and ocular findings in phenylketonuria. 61
32450880 2020
2
Effect of Stimulus Orientation on Visual Function in Children with Refractive Amblyopia. 61
32392311 2020
3
[The performance of visual photoscreening for Chinese preschool children aged 4 to 5 years]. 61
32187947 2020
4
Refractive Errors and Amblyopia Among Children Screened by the UCLA Preschool Vision Program in Los Angeles County. 61
31647932 2020
5
Positive predictive value and screening performance of GoCheck Kids in a primary care university clinic. 61
31940501 2020
6
Nanophthalmos in children: morphometric and clinical characterization. 61
32058088 2020
7
Is amblyopia associated with school readiness and cognitive performance during early schooling? Findings from the Millennium Cohort Study. 61
32559208 2020
8
Correlation between higher-order aberrations and visual acuity recovery (CoHORT) after spectacles treatment for pediatric refractive amblyopia: A pilot study using iDesign measurement. 61
32059018 2020
9
[Factors influencing target refraction in children with pseudophakia after extraction of congenital cataract]. 61
32504483 2020
10
Quality of life and mental health in amblyopic children treated with and without occlusion therapy. 61
31678257 2019
11
Full time occlusion VS part time occlusion in treatment of monocular amblyopia. 61
31777509 2019
12
Evaluation of Metabolite Changes in the Occipital Cortex of Patients with Idiopathic Infantile Nystagmus or Bilateral Ametropic Amblyopia by Magnetic Resonance Spectroscopy. 61
31612650 2019
13
Ocular characteristics in a variant microcephalic primordial dwarfism type II. 61
31510961 2019
14
Zone of retinal vascularization and refractive error in premature eyes with and without spontaneously regressed retinopathy of prematurity. 61
31229607 2019
15
Corneal indices following photorefractive keratectomy in children at least 5 years after surgery. 61
31103563 2019
16
Amblyopia therapy in Asian children: factors affecting visual outcome and parents' perception of children's attitudes towards amblyopia treatment. 61
30488078 2019
17
Late Ophthalmologic Referral of Anisometropic Amblyopia: A Retrospective Study of Different Amblyopia Subtypes. 61
30946787 2019
18
Ocular findings in posterior microphthalmos. 61
30930662 2019
19
New advances in amblyopia therapy II: refractive therapies. 61
29871968 2018
20
Community outreach: An indicator for assessment of prevalence of amblyopia. 61
29941736 2018
21
New pediatric risk factors for amblyopia: strabismic versus refractive. 61
28967080 2018
22
Evaluation of a smartphone photoscreening app to detect refractive amblyopia risk factors in children aged 1-6 years. 61
30197499 2018
23
Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair. 61
29100834 2017
24
[Acupuncture mainly with "guoyanre" manipulation for amblyopia in children]. 61
29354955 2017
25
Analysis of Macular and Retinal Nerve Fiber Layer Thickness in Children with Refractory Amblyopia after Femtosecond Laser-assisted Laser In situ Keratomileusis: A Retrospective Study. 61
28875960 2017
26
Benign Yellow Dot Maculopathy: A New Macular Phenotype. 61
28366503 2017
27
An Assessment of the Contrast Sensitivity in Patients with Ametropic and Anisometropic Amblyopia in Achieving the Corrected Visual Acuity of 1.0. 61
28169333 2017
28
Refractive Errors and Amblyopia in the UCLA Preschool Vision Program; First Year Results. 61
27640004 2016
29
Visual outcomes after spectacles treatment in children with bilateral high refractive amblyopia. 61
27426739 2016
30
Prevalence and pattern of amblyopia among primary school pupils in Kosofe town, Lagos state, Nigeria. 61
28000640 2016
31
OCT in a Myelinated Retinal Nerve Fiber Syndrome with Reduced Vision. 61
27529609 2016
32
Refractive Amblyopia among children in Ibadan: the need for amblyopia screening programmes. 61
27280236 2015
33
The incidence and visual acuity outcomes of children identified with ametropic amblyopia by vision screening. 61
25828821 2015
34
SCHOOL INTEGRATION FOR PATIENTS WITH AMBLYOPIA. 61
27373116 2015
35
Performance of the Plusoptix A09 photoscreener in detecting amblyopia risk factors in Chinese children attending an eye clinic. 61
26030210 2015
36
Impact of cylinder axis on the treatment for astigmatic amblyopia. 61
24384526 2014
37
Perceptual learning improves stereoacuity in amblyopia. 61
24508791 2014
38
Stereoscopic visual acuity in types of ametropic amblyopia in children. 61
24804304 2014
39
Comparison of surgically induced astigmatism in patients with horizontal rectus muscle recession. 61
25161948 2014
40
Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children. 61
24890172 2014
41
Isolated congenital hereditary cataract in a dizygotic twin: prenatal ultrasonographic diagnosis. 61
23931615 2013
42
Prevalence and etiology of amblyopia in Southern India: results from screening of school children aged 5-15 years. 61
23865603 2013
43
[Visual impairment and blindness in children in a Malawian school for the blind]. 61
23959513 2013
44
Regression of myelinated retinal nerve fibers in a glaucomatous eye. 61
23708924 2013
45
Update on management of herpes keratitis in children. 61
23665524 2013
46
The outcome of combining home based and clinic based amblyopia therapy among preschool children. 61
23749015 2013
47
Plusoptix photoscreening may replace cycloplegic examination in select pediatric ophthalmology patients. 61
23522941 2013
48
Congenital ptosis repair-surgical, cosmetic, and functional outcome: a report of 162 cases. 61
23561601 2013
49
Incidence of strabismus and amblyopia in preverbal children previously diagnosed with pseudoesotropia. 61
24141760 2013
50
Do children and adolescents with attention deficit hyperactivity disorder have ocular abnormalities? 61
22505050 2012

Variations for Ametropic Amblyopia

Expression for Ametropic Amblyopia

Search GEO for disease gene expression data for Ametropic Amblyopia.

Pathways for Ametropic Amblyopia

GO Terms for Ametropic Amblyopia

Biological processes related to Ametropic Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signaling receptor activity GO:2000272 8.96 MTRNR2L5 MTRNR2L4
2 negative regulation of execution phase of apoptosis GO:1900118 8.62 MTRNR2L5 MTRNR2L4

Molecular functions related to Ametropic Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.62 MTRNR2L5 MTRNR2L4

Sources for Ametropic Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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