MCID: AML051
MIFTS: 20

Aml with Myelodysplasia-Related Features

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Aml with Myelodysplasia-Related Features

MalaCards integrated aliases for Aml with Myelodysplasia-Related Features:

Name: Aml with Myelodysplasia-Related Features 20
Acute Myeloid Leukemia with Multilineage Dysplasia 20 6
Acute Myeloid Leukaemia with Myelodysplasia-Related Features 20
Aml with Multilineage Dysplasia 20

Classifications:



Summaries for Aml with Myelodysplasia-Related Features

MalaCards based summary : Aml with Myelodysplasia-Related Features, also known as acute myeloid leukemia with multilineage dysplasia, is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Aml with Myelodysplasia-Related Features is NPM1 (Nucleophosmin 1). The drugs Fludarabine and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone.

Related Diseases for Aml with Myelodysplasia-Related Features

Diseases related to Aml with Myelodysplasia-Related Features via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 11.4
2 myeloid leukemia 10.8
3 myelodysplastic syndrome 10.5
4 leukemia 10.4
5 autoimmune disease 10.2
6 rheumatoid arthritis 10.2
7 myeloma, multiple 10.2
8 leukemia, acute lymphoblastic 10.2
9 graft-versus-host disease 10.2
10 membranous nephropathy 10.2
11 lymphoproliferative syndrome 10.2
12 childhood acute myeloid leukemia 10.2
13 neutropenia 10.2
14 pancytopenia 10.2
15 thrombocytosis 10.2
16 glomerulonephritis 10.2

Graphical network of the top 20 diseases related to Aml with Myelodysplasia-Related Features:



Diseases related to Aml with Myelodysplasia-Related Features

Symptoms & Phenotypes for Aml with Myelodysplasia-Related Features

Drugs & Therapeutics for Aml with Myelodysplasia-Related Features

Drugs for Aml with Myelodysplasia-Related Features (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
2
Mycophenolic acid Approved Phase 3 24280-93-1 446541
3
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Busulfan Approved, Investigational Phase 3 55-98-1 2478
7
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
8
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
9
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
10
Daunorubicin Approved Phase 3 20830-81-3 30323
11
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13 Immunosuppressive Agents Phase 3
14 Immunologic Factors Phase 3
15 Anti-Infective Agents Phase 3
16 Antifungal Agents Phase 3
17 Antitubercular Agents Phase 3
18 Cyclosporins Phase 3
19 Antirheumatic Agents Phase 3
20 Dermatologic Agents Phase 3
21 Calcineurin Inhibitors Phase 3
22 Alkylating Agents Phase 3
23 Folic Acid Antagonists Phase 3
24 Vitamin B Complex Phase 3
25 Vitamin B9 Phase 3
26 Folate Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Anti-Bacterial Agents Phase 3
29
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
30
Etoposide Approved Phase 2 33419-42-0 36462
31
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
34 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
35
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
36
Lenograstim Approved, Investigational Phase 2 135968-09-1
37
Vidarabine Approved, Investigational Phase 2 24356-66-9 32326 21704
38
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
39
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
40
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
41
Decitabine Approved, Investigational Phase 2 2353-33-5 451668
42
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
43
midostaurin Approved, Investigational Phase 2 120685-11-2 104937 9829523
44
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
45
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
46
tipifarnib Investigational Phase 2 192185-72-1 159324
47
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
48
Tosedostat Investigational Phase 2 238750-77-1
49
Entinostat Investigational Phase 2 209783-80-2
50 Staurosporine Experimental Phase 2 62996-74-1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Multi-center Phase III Study Comparing Myeloablative to Nonmyeloablative Transplant Conditioning in Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia Completed NCT00322101 Phase 3 cyclophosphamide;mycophenolate mofetil;busulfan;cyclosporine;fludarabine phosphate;tacrolimus;methotrexate
2 Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin &Amp; Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age >/= 60 Years) Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
3 Randomized Phase II Trial of Timed Sequential Therapy (TST) With Alvocidib (Flavopiridol), Ara-C and Mitoxantrone (FLAM) vs. "7+3" for Adults Age 70 and Under With Newly Diagnosed Acute Myelogenous Leukemia (AML) Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
4 A Randomized Phase II Trial of Tipifarnib (R115777, ZARNESTRA, NSC #702818) in Combination With Oral Etoposide (VP-16) in Elderly Adults With Newly Diagnosed, Previously Untreated Acute Myelogenous Leukemia (AML) Completed NCT00602771 Phase 2 tipifarnib;etoposide
5 Nonmyeloablative Allogeneic Peripheral Blood Stem Cell Transplantation From HLA Matched Related Donors for Treatment of Older Patients With De Novo or Secondary Acute Myeloid Leukemia in First Complete Remission Completed NCT00045435 Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
6 Umbilical Cord Blood (UCB) Allogeneic Stem Cell Transplant for Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
7 A Phase II Study of Farnesyl Transferase Inhibitor R115777 (Zarnestra) (R115777 ( Zarnestra), Tipifarnib, R115777, NSC #702818) in Elderly Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
8 A Phase II Study of Tosedostat in Combination With Either Cytarabine or Decitabine in Newly Diagnosed AML or High-Risk MDS Completed NCT01567059 Phase 2 tosedostat;cytarabine;decitabine
9 Decitabine Followed by Bone Marrow Transplant and High-Dose Cyclophosphamide for the Treatment of Relapsed and Refractory Acute Myeloid Neoplasms Completed NCT01707004 Phase 2 decitabine;fludarabine phosphate;busulfan;cyclophosphamide;tacrolimus;mycophenolate mofetil
10 Randomized Phase II Study Comparing Two Administration Schedules of Flavopiridol (Alvocidib, NSC 649890, IND 46, 211) Given in Timed Sequential Combination With Cytosine Arabinoside (Ara-C) and Mitoxantrone Hydrochloride for Adults With Newly Diagnosed, Previously Untreated, Poor Risk Acute Myelogenous Leukemias (AML) Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
11 A Randomized Phase II Trial of Azacitidine With or Without the Histone Deacetylase Inhibitor Entinostat for the Treatment of Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia (Dysplastic Type), and Acute Myeloid Leukemia With Multilineage Dysplasia Completed NCT00313586 Phase 2 Azacitidine;Entinostat
12 Phase Ib/II Study of the Glutaminase Inhibitor CB-839 in Combination With Azacitidine in Patients With Advanced Myelodysplastic Syndrome Recruiting NCT03047993 Phase 1, Phase 2 Azacitidine;Glutaminase Inhibitor CB-839
13 A Single Arm, Phase II Study of Eltrombopag to Enhance Platelet Count Recovery in Elderly Patients With Acute Myeloid Leukemia Undergoing Remission Induction Therapy Active, not recruiting NCT02071901 Phase 2 eltrombopag olamine
14 OAG and Decitabine for Newly Diagnosed Acute Myeloid Leukemia Patients Greater Than or Equal to 65 Years of Age Terminated NCT02029417 Phase 2 cytarabine;omacetaxine mepesuccinate;decitabine
15 A Phase II Study of Subcutaneous Bortezomib as Maintenance Therapy for Patients With High-risk Acute Myeloid Leukemia in Remission Terminated NCT01465386 Phase 2 bortezomib
16 A Phase 2 Study of Decitabine in Combination With Midostaurin (PKC412) for Elderly Patients With Newly Diagnosed FLT3-ITD/TKD Positive Acute Myeloid Leukemia Terminated NCT01846624 Phase 2 Decitabine;Midostaurin
17 Phase I Trial of R115777 (NSC 702818) in Relapsed, Refractory or High Risk Myeloid Leukemia Completed NCT00101296 Phase 1 tipifarnib
18 A Phase 1 Study of Suberoylanilide Hydroxamic Acid (Vorinostat, SAHA) in Combination With Idarubicin in Relapsed or Refractory Leukemia Completed NCT00331513 Phase 1 vorinostat;idarubicin
19 Characterization of the Mechanisms of Action of Resistance to Azacitidine in High-risk Myelodysplastic Syndromes and Acute Myeloid Leukemia With Multilineage Dysplasia Unknown status NCT01210274

Search NIH Clinical Center for Aml with Myelodysplasia-Related Features

Genetic Tests for Aml with Myelodysplasia-Related Features

Anatomical Context for Aml with Myelodysplasia-Related Features

MalaCards organs/tissues related to Aml with Myelodysplasia-Related Features:

40
Myeloid, Bone Marrow, Bone

Publications for Aml with Myelodysplasia-Related Features

Articles related to Aml with Myelodysplasia-Related Features:

(show all 22)
# Title Authors PMID Year
1
Upfront allogeneic hematopoietic cell transplantation (HCT) versus remission induction chemotherapy followed by allogeneic HCT for acute myeloid leukemia with multilineage dysplasia: A propensity score matched analysis. 61
30370944 2019
2
Azacitidine improves the T-cell repertoire in patients with myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. 61
26209197 2015
3
Characteristics of Sweet Syndrome in patients with acute myeloid leukemia. 61
25630528 2015
4
Positive impact of chronic graft-versus-host disease on the outcome of patients with de novo myelodysplastic syndrome after allogeneic hematopoietic cell transplantation: a single-center analysis of 115 patients. 61
24127668 2014
5
Survival of European patients diagnosed with myeloid malignancies: a HAEMACARE study. 61
22983589 2013
6
Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1. 61
21965128 2012
7
Duplication of isodicentric chromosome 21, idic(21)(p11.2), leading to pentasomy 21q in acute myeloid leukemia with multilineage dysplasia. 61
19737652 2009
8
Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report. 61
19566938 2009
9
Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia. 61
19367383 2009
10
Acute myeloid leukemia with multilineage dysplasia in an alpaca. 61
18761521 2008
11
[Acute myeloid leukemia invasion of the central nervous system, detected only along the Virchow Robin space]. 61
18572812 2008
12
Acute myeloid leukemia with multilineage dysplasia in children. 61
18055345 2007
13
Marrow fibrosis as a risk factor for posttransplantation outcome in patients with advanced myelodysplastic syndrome or acute myeloid leukemia with multilineage dysplasia. 61
17317588 2007
14
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases. 61
17587881 2007
15
Complete cytogenetic and molecular response to treatment with imatinib mesylate for philadelphia chromosome positive acute myeloid leukemia with multilineage dysplasia. 61
17065015 2006
16
[Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation]. 61
16440806 2005
17
Pretransplantation induction chemotherapy and posttransplantation relapse in patients with advanced myelodysplastic syndrome. 61
15625546 2005
18
Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning. 61
15059843 2004
19
Classification of acute leukemias. 61
14552428 2003
20
Efficacy and toxicity of low-dose melphalan in myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. 61
12937849 2003
21
[Simultaneous occurrence of acute myeloid leukemia with multilineage dysplasia and multiple myeloma]. 61
12649833 2003
22
De novo acute myeloid leukemia with multilineage dysplasia: treatment results and prognostic evaluation from a series of 44 patients treated with fludarabine, cytarabine and G-CSF (FLAG). 61
12071935 2002

Variations for Aml with Myelodysplasia-Related Features

ClinVar genetic disease variations for Aml with Myelodysplasia-Related Features:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NPM1 NM_002520.6(NPM1):c.864_873delinsTTTAAGGATTCGTC (p.Trp288fs) Indel Pathogenic 810668 rs1581263026 5:170837548-170837557 5:171410544-171410553

Expression for Aml with Myelodysplasia-Related Features

Search GEO for disease gene expression data for Aml with Myelodysplasia-Related Features.

Pathways for Aml with Myelodysplasia-Related Features

GO Terms for Aml with Myelodysplasia-Related Features

Sources for Aml with Myelodysplasia-Related Features

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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