Aliases & Classifications for Amnestic Disorder

MalaCards integrated aliases for Amnestic Disorder:

Name: Amnestic Disorder 12 15 70
Amnesia 12 73 54 44 15 17 70
Korsakoff's Psychosis or Syndrome 12
Amnestic Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10914
ICD9CM 34 294.0
MeSH 44 D000647
NCIt 50 C2867
SNOMED-CT 67 247606008 3298001
ICD10 32 R41.3
UMLS 70 C0002622 C0002625

Summaries for Amnestic Disorder

Disease Ontology : 12 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.

MalaCards based summary : Amnestic Disorder, also known as amnesia, is related to wernicke-korsakoff syndrome and agnosia, and has symptoms including mental and behavioral signs and symptoms, forgetful and memory loss. An important gene associated with Amnestic Disorder is PREP (Prolyl Endopeptidase), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Donepezil and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Amnesia is a deficit in memory caused by brain damage or disease, but it can also be caused temporarily... more...

Related Diseases for Amnestic Disorder

Diseases related to Amnestic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 455)
# Related Disease Score Top Affiliating Genes
1 wernicke-korsakoff syndrome 32.0 CHAT BDNF ACHE
2 agnosia 32.0 PDYN HTR1A FOS BDNF
3 traumatic brain injury 31.9 S100B BDNF APOE
4 aphasia 31.7 PSEN1 BDNF APP APOE
5 head injury 31.4 S100B CHAT APOE
6 retrograde amnesia 31.4 PDYN LGI1 HTR1A GRIN2B FOS CREB1
7 anterograde amnesia 31.4 TSPO LGI1 HTR1A GRIN2B FOS BDNF
8 brain injury 31.2 S100B BDNF APOE
9 pain agnosia 31.0 PDYN HTR1A FOS BDNF
10 limbic encephalitis 31.0 LGI1 GRIN2B GAD1
11 post-traumatic stress disorder 30.9 PREP BDNF APOE
12 cerebrovascular disease 30.8 TSPO APP APOE ACHE
13 temporal lobe epilepsy 30.7 TSPO PDYN LGI1 HTR1A GRIN2B GAD1
14 migraine with or without aura 1 30.6 S100B PDYN HTR3A HTR1A GRIN2B FOS
15 dissociative disorder 30.6 OGN GRIN2B BDNF
16 personality disorder 30.6 HTR3A HTR1A BDNF
17 mild cognitive impairment 30.6 CHAT BDNF BCHE APP APOE
18 semantic dementia 30.5 PSEN1 APOE
19 cerebral hypoxia 30.5 FOS CREB1
20 anosognosia 30.4 PSEN1 HTR1A APOE
21 status epilepticus 30.4 TSPO LGI1 GRIN2B FOS BDNF ACHE
22 mental depression 30.4 HTR1A GRIN2B CREB1 BDNF
23 borderline personality disorder 30.3 HTR3A HTR1A BDNF
24 neurotic disorder 30.3 HTR1A CHAT BDNF ACHE
25 visual agnosia 30.3 PSEN1 APOE
26 alexia 30.3 BCHE APOE
27 depression 30.3 HTR3A HTR1A BDNF
28 substance abuse 30.2 PDYN OGN HTR1A BDNF BCHE
29 mood disorder 30.2 HTR3A HTR1A CREB1 BDNF
30 frontotemporal dementia 30.2 PSEN1 BCHE APP APOE ACHE
31 nominal aphasia 30.1 PSEN1 APOE ACHE
32 huntington disease 30.1 PDYN GRIN2B CREB1 CHAT BDNF APP
33 opiate dependence 30.1 PDYN FOS CREB1
34 stroke, ischemic 30.1 TSPO PSEN1 CREB1 BDNF APOE
35 alcohol use disorder 30.1 HTR3A HTR1A GRIN2B CREB1 BDNF
36 hydrocephalus 30.1 S100B PSEN1 BDNF APP APOE
37 stiff-person syndrome 30.0 TSPO LGI1 GAD1
38 dementia 30.0 TSPO PSEN1 CHAT BDNF BCHE APP
39 alcohol dependence 30.0 TSPO PDYN HTR3A HTR1A GRIN2B GAD1
40 conversion disorder 30.0 GAD1 BDNF
41 drug dependence 29.9 PDYN HTR3A BDNF
42 agraphia 29.9 APOE ACHE
43 fibromyalgia 29.9 TSPO PREP HTR3A BDNF
44 withdrawal disorder 29.9 TSPO PDYN HTR1A GRIN2B FOS
45 focal epilepsy 29.9 TSPO PDYN LGI1 GRIN2B
46 early-onset, autosomal dominant alzheimer disease 29.8 PSEN1 APP APOE
47 epilepsy 29.8 TSPO S100B PDYN LGI1 HTR1A GRIN2B
48 normal pressure hydrocephalus 29.7 PSEN1 BDNF APP APOE
49 autism 29.6 HTR3A HTR1A GRIN2B GAD1 BDNF APP
50 cerebral palsy 29.6 S100B GAD1 BDNF APOE

Comorbidity relations with Amnestic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Amnestic Disorder:



Diseases related to Amnestic Disorder

Symptoms & Phenotypes for Amnestic Disorder

UMLS symptoms related to Amnestic Disorder:


mental and behavioral signs and symptoms; forgetful; memory loss

GenomeRNAi Phenotypes related to Amnestic Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.5 FOS
2 Decreased viability GR00249-S 9.5 CHAT FOS PREP PSEN1
3 Decreased viability GR00381-A-1 9.5 HTR1A HTR3A
4 Decreased viability GR00381-A-3 9.5 HTR1A HTR3A
5 Decreased viability GR00386-A-1 9.5 APOE CHAT
6 Decreased viability GR00402-S-2 9.5 HTR1A HTR3A LGI1 OGN

MGI Mouse Phenotypes related to Amnestic Disorder:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 ACHE APOE APP BDNF CHAT CREB1
2 homeostasis/metabolism MP:0005376 10.39 ACHE APOE APP BCHE BDNF CHAT
3 growth/size/body region MP:0005378 10.36 ACHE APOE APP BDNF CHAT CREB1
4 mortality/aging MP:0010768 10.27 ACHE APOE APP BCHE BDNF CHAT
5 nervous system MP:0003631 10.2 ACHE APOE APP BDNF CHAT CREB1
6 integument MP:0010771 10.1 APOE APP BDNF FOS HTR3A LGI1
7 adipose tissue MP:0005375 10.04 ACHE APOE FOS HTR1A LGI1 PDYN
8 no phenotypic analysis MP:0003012 9.91 ACHE APOE APP BDNF GAD1 GRIN2B
9 normal MP:0002873 9.81 APP BDNF CHAT CREB1 FOS GAD1
10 reproductive system MP:0005389 9.7 ACHE APOE APP BCHE BDNF CHAT
11 skeleton MP:0005390 9.32 APOE APP CHAT CREB1 FOS GAD1

Drugs & Therapeutics for Amnestic Disorder

Drugs for Amnestic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 4 120014-06-4 3152
2 Neurotransmitter Agents Phase 4
3 Cholinesterase Inhibitors Phase 4
4 Cholinergic Agents Phase 4
5 Nootropic Agents Phase 4
6 Rosuvastatin Calcium Phase 1, Phase 2 147098-20-2
7 Antimetabolites Phase 1, Phase 2
8 Anticholesteremic Agents Phase 1, Phase 2
9 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
10 Hypolipidemic Agents Phase 1, Phase 2
11 Lipid Regulating Agents Phase 1, Phase 2
12 Calcium, Dietary Phase 1, Phase 2
13 Phytoestrogens Phase 2
14
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271
15
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
16
Propofol Approved, Investigational, Vet_approved Phase 1 2078-54-8 4943
17
Dexmedetomidine Approved, Vet_approved Phase 1 113775-47-6 68602 5311068
18
Ketamine Approved, Vet_approved Phase 1 6740-88-1 3821
19
Thiopental Approved, Vet_approved Phase 1 76-75-5 3000715
20 Psychotropic Drugs Phase 1
21 Hypnotics and Sedatives Phase 1
22 Anesthetics Phase 1
23 Anesthetics, General Phase 1
24 Anesthetics, Intravenous Phase 1
25 Anti-Anxiety Agents Phase 1
26 GABA Modulators Phase 1
27 Analgesics Phase 1
28 Anticonvulsants Phase 1
29 Analgesics, Non-Narcotic Phase 1
30 Adrenergic alpha-Agonists Phase 1
31 Anesthetics, Dissociative Phase 1
32 Excitatory Amino Acid Antagonists Phase 1
33 Adrenergic Agents Phase 1
34 Adrenergic Agonists Phase 1
35 Pharmaceutical Solutions Phase 1
36
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
37
Lorazepam Approved 846-49-1 3958
38
Acetaminophen Approved 103-90-2 1983
39
Ondansetron Approved 99614-02-5 4595
40
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
41
Hydrocodone Approved, Illicit, Investigational 125-29-1 5284569
42
Lidocaine Approved, Vet_approved 137-58-6 3676
43
Nitrous oxide Approved, Vet_approved 10024-97-2 948
44
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
45
Acetylcysteine Approved, Investigational 616-91-1 12035
46
Levoleucovorin Approved, Investigational 68538-85-2 149436
47
Methylcobalamin Approved, Investigational 13422-55-4
48
Desflurane Approved 57041-67-5 42113
49
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
50
Esmolol Approved 81147-92-4, 103598-03-4 59768

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 A One-Year, Multicenter, Randomized, Double-Blind, Placebo-Controlled Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI) Completed NCT00293176 Phase 4 Donepezil Hydrochloride;Placebo
2 Effect of Rosuvastatin on Immunological Markers After Traumatic Brain Injury: Clinical Randomized Double Blind Study Phase 2 Completed NCT00990028 Phase 1, Phase 2 Rosuvastatin;Placebo
3 Phase II Study of Rosuvastatin´s Effect on Amnesia and Orientation Through Galveston Outcome Amnesia Test in Humans With Moderate Head Injury Completed NCT00329758 Phase 2 rosuvastatin;Placebo
4 A 6-Month Prospective, Multi-Center, Double-Blind, Placebo-Controlled, Randomized, Adaptive-Trial-Design Study to Evaluate the Safety and Efficacy of 80mg b.i.d Ladostigil in Patients With Mild to Moderate Probable Alzheimer's Disease Completed NCT01354691 Phase 2 ladostigil hemitartrate
5 Phytoestrogens and Cognition in Menopause Completed NCT00051402 Phase 2 Isoflavones
6 Modulation of Long-term Memory by the Experience of Pain During Sedation With Anesthetics Completed NCT02515890 Phase 1 Dexmedetomidine;Midazolam;Ketamine
7 Effect of Affective Content on Drug Induced Amnesia of Episodic Memory Completed NCT00142493 Phase 1 Propofol;Thiopental Sodium;Dexmedetomidine Hydrochloride;Midazolam Hydrochloride;placebo
8 From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations Unknown status NCT01455207
9 Early Rehabilitation of Patients With Posttraumatic Amnesia. A Clinical Controlled Investigation of the Effect of a Nursing Programme in Patients With Traumatic Brain Injury in the Acute Care Unknown status NCT00476528
10 Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease Unknown status NCT02576821
11 The Effects of Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia Following a Traumatic Brain Injury Unknown status NCT02792985
12 Multi-Center Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study) Unknown status NCT03661034
13 Clinical Predictors and Epigenetic Markers for Liver Fibrosis in Alpha-1 Antitrypsin Deficiency Completed NCT01810458 Midazolam;Fentanyl;Lidocaine;Acetaminophen;Lorazepam;Oxycodone/Acetaminophen;Ondansetron
14 Does Midazolam Cause Effective Anterograde Amnesia in Noisy Orthopedic Surgeries? Completed NCT04232150 single-dose midazolam for sedation under spinal anesthesia.;Double-dose midazolam for sedation under spinal anesthesia.
15 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia : a Serie of 3 Cases Report Completed NCT03739008
16 Transient Global Amnesia (TGA) Exploratory Study of the Default Mode Network in Resting State Functional MRI (fMRI) During the Acute Phase Completed NCT02010853
17 Impact of Somatic Yoga and Meditation on Fall Risk, Function, and Quality of Life for Chemotherapy-Induced Peripheral Neuropathy Syndrome in Cancer Survivors Completed NCT03786055
18 Simplification and Implementation of Awake Fibreoptic Orotracheal Intubation Completed NCT03343496
19 Structural and Functional Imaging of Neurologically Impaired Patients and Normal Volunteers With 1.5 and 3.0 Tesla MRI Completed NCT00001362
20 Dose Response Effect of Nitrous Oxide on Amnesia in Healthy Children Completed NCT02050152 0% nitrous oxide, 30% nitrous oxide and 60% nitrous oxide
21 Basal Forebrain Amnesia After Surgery for Anterior Communicating Aneurysm: High Resolution 3-dimensional (3D) Magnetic Resonance (MR) Imaging Findings Completed NCT01919775
22 A Six-month, Double-blind, Placebo-controlled, Single Site Study of Cerefolin NAC on Blood Homocysteine, Oxidative Stress, and Beta-amyloid Biomarkers That May Potentiate Inflammation and Neuronal Damage in Older Individuals With Memory Complaints Who Have Not Been Clinically Diagnosed With Mild Cognitive Impairment, Vascular Dementia, or Alzheimer's Disease Completed NCT00597376
23 NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support) Completed NCT01370954
24 Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI Completed NCT00288314
25 A Randomised Controlled Study of Organ Protection Comparing Desflurane and Propofol in Adult Patients Undergoing Coronary Artery Surgery With Cardiopulmonary Bypass Completed NCT00400790 propofol;desflurane
26 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
27 Validation of the German Short Version of the Autobiographical Memory Interview in Patients With Depression and Healthy Controls Recruiting NCT04516863
28 A Multicenter, Randomized, Single-blind, Parallel Controlled Clinical Study on the Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy Recruiting NCT04727034 Remimazolam tosylate;Propofol
29 Improving Patient Outcomes Using Multimodal Perioperative Pain Management: The ComfortSafe Program Recruiting NCT04046068
30 OCT-Angiography and Adaptive Optics in Patients With Memory Impairment Recruiting NCT04389437
31 IMOVE: Improvisational Movement for People With Memory Loss and Their Caregivers Recruiting NCT03333837
32 Screening for Memory Studies Active, not recruiting NCT01123018
33 Assessment of Emotional Memory During Transient Global Amnesia Not yet recruiting NCT04548037
34 Development of a Biomarker Database to Investigate Aß, P-tau, and NfL Blood-Based Biomarkers and Digital Biomarkers in Older Participants Screened for Preclinical Alzheimer's Disease (AD), Prodromal AD, or Mild AD Not yet recruiting NCT04733989
35 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560
36 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287
37 Biomarkers in Neurodegenerative Diseases Withdrawn NCT04055532

Search NIH Clinical Center for Amnestic Disorder

Cochrane evidence based reviews: amnesia

Genetic Tests for Amnestic Disorder

Anatomical Context for Amnestic Disorder

MalaCards organs/tissues related to Amnestic Disorder:

40
Brain, Temporal Lobe, Cortex, Amygdala, Heart, Thalamus, Spinal Cord

Publications for Amnestic Disorder

Articles related to Amnestic Disorder:

(show top 50) (show all 10339)
# Title Authors PMID Year
1
Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. 54 61
19774505 2010
2
Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role. 61 54
18221797 2008
3
Antibodies to voltage-gated potassium and calcium channels in epilepsy. 61 54
16870397 2006
4
Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. 54 61
16472967 2006
5
Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase. 54 61
15713471 2005
6
The prolyl oligopeptidase family. 54 61
11915948 2002
7
Inhibition of passive-avoidance memory formation in the day-old chick by the opioid cytochrophin-4. 61 54
10940321 2000
8
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity. 54 61
10802030 2000
9
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. 54 61
9918593 1999
10
Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. 54 61
9886142 1998
11
[Biochemical studies on functional proteins in the brain nervous system. Neurobiochemical studies on nerve growth factor]. 54 61
8709005 1996
12
[The interaction of dopamine and opioid receptors in the re-establishing of an amnesic and forgotten memory trace by quinpirole]. 54 61
7773079 1995
13
Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide. 54 61
1463591 1992
14
[Experimental study of the effects of amiridin and tacrine on learning and memory]. 54 61
1893185 1991
15
Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia. 61 54
1651866 1991
16
Cholinergic receptor antagonists impair formation of intermediate-term memory in the chick. 54 61
2378607 1990
17
The role of GABAA and GABAB receptors in the development of amnesia. 61 54
2177529 1990
18
A Meta-Analysis of Hippocampal and Amygdala Volumes in Patients Diagnosed With Dissociative Identity Disorder. 61
33433297 2021
19
Protective effect of ginsenoside Rb1 against chronic restraint stress (CRS)-induced memory impairments in rats. 61
33545198 2021
20
Temporal Aneurysmorrhaphy Technique for the Management of Complex Middle Cerebral Artery Aneurysm: A Video Case. 61
33540089 2021
21
Urtica dioica extracts abolish scopolamine-induced neuropathies in rats. 61
33405105 2021
22
Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. 61
33793545 2021
23
AMPA Receptor Expression Requirement During Long-Term Memory Retrieval and Its Association with mTORC1 Signaling. 61
33244735 2021
24
Recovering Spatial Information through Reactivation: Brain Oxidative Metabolism Involvement in Males and Females. 61
33571597 2021
25
Synthesis of 4,6-diphenylpyrimidin-2-ol derivatives as new benzodiazepine receptor ligands. 61
33631464 2021
26
What Causes Anterograde Amnesia? 61
33794519 2021
27
When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia. 61
33587931 2021
28
On the tip of the pen: Effects of character-level lexical variables and handwriter-level individual differences on orthographic retrieval difficulties in Chinese handwriting. 61
33719764 2021
29
What a headache! Reviewing mild traumatic brain injury management in a new trauma service. 61
33767477 2021
30
Factors influencing developmental differences in retention of Pavlovian fear conditioning. 61
33661657 2021
31
A network analysis of posttraumatic stress symptoms among help-seeking refugees in Kenya. 61
33476983 2021
32
Improvement of cognitive function in mice by Citrus reticulata var. kinnow via modulation of central cholinergic system and oxidative stress. 61
33651274 2021
33
[Research advances of Zaoren Anshen prescription preparations]. 61
33787126 2021
34
Human Herpesvirus 6 Encephalitis in Immunocompetent and Immunocompromised Hosts. 61
33587722 2021
35
Accelerated long-term forgetting in focal epilepsy: Do interictal spikes during sleep matter? 61
33476422 2021
36
Digital mapping of Lewy bodies and neurites in alpha-synuclein stained large cerebral hemispheric sections from three patients with dementia with Lewy bodies showing psychotic manifestations: A pilot study. 61
33548407 2021
37
Lacidipine Prevents Scopolamine-Induced Memory Impairment by Reducing Brain Oxido-nitrosative Stress in Mice. 61
33721210 2021
38
Outcomes 1 and 2 Years After Moderate to Severe Traumatic Brain Injury: An International Comparative Study. 61
33190797 2021
39
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach. 61
33540354 2021
40
Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus. 61
33740236 2021
41
Nonalcoholic Wernicke-Korsakoff Syndrome Resulting From Psychosis. 61
33620916 2021
42
Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury. 61
33646273 2021
43
Feasibility of modifying the hospital environment to reduce the length of amnesia after traumatic brain injury: a pilot randomized controlled trial. 61
33693639 2021
44
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. 61
33476932 2021
45
Gabapentin-Induced Myokymia: A Case Report. 61
33480615 2021
46
Factors associated with recurrent transient global amnesia: systematic review and pathophysiological insights. 61
33675214 2021
47
Ozone-induced encephalopathy: A novel iatrogenic entity. 61
33657263 2021
48
Transient global amnesia does not increase the risk of subsequent ischemic stroke: a propensity score-matched analysis. 61
33651152 2021
49
Factors Affecting Participation in Physical Therapy During Posttraumatic Amnesia. 61
32745545 2021
50
Electroconvulsive therapy related autobiographical amnesia: a review and case report. 61
33467984 2021

Variations for Amnestic Disorder

Expression for Amnestic Disorder

Search GEO for disease gene expression data for Amnestic Disorder.

Pathways for Amnestic Disorder

Pathways related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 GRIN2B GAD1 CREB1 CHAT BCHE ACHE
2
Show member pathways
12.5 PDYN GRIN2B FOS CREB1 BDNF
3 12.05 HTR1A GRIN2B FOS CREB1 BDNF
4 11.95 PSEN1 GRIN2B APP APOE
5 11.92 GRIN2B FOS CREB1 BDNF
6 11.84 TSPO S100B HTR1A APOE
7 11.76 HTR3A HTR1A CREB1 CHAT BDNF
8 11.76 S100B PSEN1 HTR1A GRIN2B GAD1 CREB1
9
Show member pathways
11.73 PDYN GRIN2B CREB1
10
Show member pathways
11.67 TNFSF12 BDNF APP
11
Show member pathways
11.56 PSEN1 BDNF APP
12 11.53 GAD1 CREB1 BDNF
13 11.46 S100B GAD1 CHAT BDNF
14 11.44 FOS CREB1 ACHE
15
Show member pathways
11.43 PDYN GRIN2B FOS CREB1 BDNF
16 11.32 PSEN1 APP APOE
17 11.03 CHAT BCHE ACHE
18
Show member pathways
10.89 GAD1 CHAT ACHE
19 10.75 CREB1 BDNF
20 10.71 S100B APP
21 10.66 CHAT ACHE
22 10.39 CHAT ACHE

GO Terms for Amnestic Disorder

Cellular components related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.02 TNFSF12 S100B OGN LGI1 BDNF BCHE
2 extracellular region GO:0005576 10.02 TNFSF12 S100B PDYN OGN LGI1 BDNF
3 perinuclear region of cytoplasm GO:0048471 9.88 TNFSF12 S100B PSEN1 BDNF APP ACHE
4 dendrite GO:0030425 9.83 PSEN1 PDYN HTR1A BDNF APOE
5 neuron projection GO:0043005 9.73 PSEN1 HTR3A GRIN2B FOS CHAT APP
6 neuromuscular junction GO:0031594 9.63 PSEN1 APP ACHE
7 axon GO:0030424 9.63 PSEN1 HTR3A GAD1 CREB1 BDNF APP
8 ciliary rootlet GO:0035253 9.49 PSEN1 APP
9 nuclear envelope lumen GO:0005641 9.48 BCHE APP
10 synapse GO:0045202 9.32 PSEN1 PDYN LGI1 HTR3A HTR1A GRIN2B
11 synaptic cleft GO:0043083 9.13 LGI1 APOE ACHE

Biological processes related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.95 LGI1 FOS BDNF APP ACHE
2 response to drug GO:0042493 9.8 TSPO GAD1 FOS CREB1 BCHE
3 chemical synaptic transmission GO:0007268 9.77 PDYN HTR3A HTR1A GRIN2B GAD1
4 axonogenesis GO:0007409 9.74 S100B CREB1 APP
5 memory GO:0007613 9.71 PSEN1 CREB1 BDNF
6 astrocyte activation GO:0048143 9.58 PSEN1 APP
7 locomotory exploration behavior GO:0035641 9.58 GAD1 APOE
8 negative regulation of long-term synaptic potentiation GO:1900272 9.56 APP APOE
9 learning or memory GO:0007611 9.56 S100B PSEN1 GRIN2B APP
10 neuron projection maintenance GO:1990535 9.52 PSEN1 APP
11 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.51 PSEN1 APP
12 modulation of age-related behavioral decline GO:0090647 9.49 PSEN1 APP
13 serotonin receptor signaling pathway GO:0007210 9.48 HTR3A HTR1A
14 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.46 PSEN1 APP
15 astrocyte activation involved in immune response GO:0002265 9.43 PSEN1 APP
16 neurotransmitter biosynthetic process GO:0042136 9.33 GAD1 CHAT ACHE
17 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.32 PSEN1 APP
18 amyloid precursor protein metabolic process GO:0042982 9.13 PSEN1 APOE ACHE
19 positive regulation of amyloid fibril formation GO:1905908 8.8 PSEN1 APP APOE

Molecular functions related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.41 TSPO TNFSF12 S100B PSEN1 PREP OGN
2 signaling receptor binding GO:0005102 9.65 TNFSF12 LGI1 BDNF APP APOE
3 serotonin binding GO:0051378 9.4 HTR3A HTR1A
4 glutamate binding GO:0016595 9.37 GRIN2B GAD1
5 growth factor receptor binding GO:0070851 9.32 PSEN1 APP
6 cholinesterase activity GO:0004104 9.16 BCHE ACHE
7 acetylcholinesterase activity GO:0003990 8.96 BCHE ACHE
8 amyloid-beta binding GO:0001540 8.92 GRIN2B BCHE APOE ACHE

Sources for Amnestic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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