Aliases & Classifications for Amnestic Disorder

MalaCards integrated aliases for Amnestic Disorder:

Name: Amnestic Disorder 12 15 73
Amnesia 12 76 55 44 73
Korsakoff's Psychosis or Syndrome 12
Amnestic Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10914
ICD10 33 R41.3
ICD9CM 35 294.0
MeSH 44 D000647
NCIt 50 C2867

Summaries for Amnestic Disorder

Disease Ontology : 12 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.

MalaCards based summary : Amnestic Disorder, also known as amnesia, is related to anterograde amnesia and wernicke-korsakoff syndrome, and has symptoms including mental and behavioral signs and symptoms, forgetful and memory loss. An important gene associated with Amnestic Disorder is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are CREB Pathway and Development HGF signaling pathway. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain and pituitary, and related phenotypes are Increased transferrin (TF) endocytosis and behavior/neurological

Wikipedia : 76 Amnesia is a deficit in memory caused by brain damage, disease, or psychological trauma. Amnesia can... more...

Related Diseases for Amnestic Disorder

Diseases related to Amnestic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 anterograde amnesia 32.3 EIF4G2 HTR1A
2 wernicke-korsakoff syndrome 32.2 ACHE CHAT
3 transient global amnesia 30.2 BDNF FOS PSEN1
4 retrograde amnesia 10.9
5 dissociative amnesia 10.7 HTR1A PDYN
6 schizophrenia 5 10.7 HTR3A HTR6
7 cyclic vomiting syndrome 10.6 CNR1 HTR3A
8 social phobia 10.5 HTR1A HTR3A
9 butyrylcholinesterase deficiency 10.5 ACHE BCHE
10 autoimmune encephalitis 10.4 CNR1 LGI1
11 childhood disintegrative disease 10.4 BDNF LGI1
12 cannabis abuse 10.3 BDNF CNR1
13 psychosexual disorder 10.3 HTR1A HTR7
14 premature ejaculation 10.3 HTR1A HTR3A
15 depression 10.3 BDNF HTR1A HTR3A
16 obsessive-compulsive disorder 10.2 BDNF HTR1A HTR3A
17 brunner syndrome 10.2 HTR1A HTR3A HTR7
18 ocular dominance 10.2 BDNF CHAT CREB1
19 toxic encephalopathy 10.1 ACHE BDNF CREB1
20 drug dependence 10.1 BDNF CNR1 PDYN
21 supranuclear palsy, progressive, 1 10.1 ACHE CHAT PSEN1
22 generalized anxiety disorder 10.1 BDNF HTR1A HTR3A TSPO
23 kleptomania 10.1 HTR1A HTR7
24 panic disorder 10.1 BDNF HTR1A HTR3A TSPO
25 sudden infant death syndrome 10.1 BDNF CHAT HTR1A HTR3A
26 mental depression 10.0 BDNF HTR1A HTR7
27 mood disorder 10.0 BDNF CREB1 HTR1A
28 marcus gunn phenomenon 10.0 CHAT FOS
29 tendinosis 10.0 ACHE BDNF CHAT CNR1
30 rumination disorder 10.0 ACHE HTR1A HTR3A HTR7
31 colonic pseudo-obstruction 9.9 ACHE BCHE HTR7
32 psychotic disorder 9.9 BDNF CNR1 HTR1A HTR3A
33 heroin dependence 9.8 BDNF PDYN
34 agraphia 9.8 ACHE BCHE PSEN1
35 major depressive disorder 9.8 BDNF CREB1 HTR1A HTR3A
36 neuroleptic malignant syndrome 9.8
37 astrocytoma 9.7
38 pilocytic astrocytoma 9.7
39 schizoaffective disorder 9.7
40 dementia, lewy body 9.7 ACHE BCHE PSEN1
41 temporal lobe epilepsy 9.7 BDNF HTR1A LGI1 PDYN TSPO
42 cerebral hypoxia 9.7 CREB1 FOS
43 anxiety 9.6 BDNF CNR1 HTR1A HTR3A TSPO
44 huntington disease 9.6 BDNF CHAT CNR1 CREB1
45 bipolar disorder 9.6 BDNF CREB1 HTR1A HTR3A
46 rett syndrome 9.6 BDNF CHAT CREB1
47 vascular dementia 9.6 ACHE BCHE CHAT PSEN1
48 status epilepticus 9.6 BDNF FOS LGI1
49 amyotrophic lateral sclerosis 1 9.4 BDNF CHAT PSEN1 TSPO
50 motion sickness 9.3 FOS HTR1A HTR3A HTR7

Comorbidity relations with Amnestic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Amnestic Disorder:



Diseases related to Amnestic Disorder

Symptoms & Phenotypes for Amnestic Disorder

UMLS symptoms related to Amnestic Disorder:


mental and behavioral signs and symptoms, forgetful, memory loss

GenomeRNAi Phenotypes related to Amnestic Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.32 HTR7 LGI1 PSEN1 TSPO CHAT CNR1

MGI Mouse Phenotypes related to Amnestic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 BDNF EIF4G2 FOS CHAT HTR1A CNR1
2 homeostasis/metabolism MP:0005376 10.24 BCHE BDNF EIF4G2 FOS CHAT HTR1A
3 growth/size/body region MP:0005378 10.22 CREB1 BDNF EIF4G2 FOS CHAT CNR1
4 mortality/aging MP:0010768 10.1 BCHE BDNF EIF4G2 FOS CHAT HTR1A
5 nervous system MP:0003631 9.93 CREB1 BDNF FOS CHAT HTR1A CNR1
6 integument MP:0010771 9.92 BDNF FOS CNR1 HTR7 LGI1 PDYN
7 normal MP:0002873 9.5 CREB1 BDNF FOS CHAT CNR1 TSPO
8 reproductive system MP:0005389 9.32 BCHE CREB1 BDNF FOS CHAT CNR1

Drugs & Therapeutics for Amnestic Disorder

Drugs for Amnestic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Vitamins Phase 4,Not Applicable
4 Micronutrients Phase 4
5 Trace Elements Phase 4
6 Vitamin B Complex Phase 4
7 Thiamin Nutraceutical Phase 4,Not Applicable
8 Folate Nutraceutical Phase 4
9 Vitamin B9 Nutraceutical Phase 4
10 Antibodies Phase 1
11 Immunoglobulins Phase 1
12 Vaccines Phase 1
13
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
14
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
15
Menthol Approved Not Applicable 2216-51-5 16666
16 tannic acid Approved, Nutraceutical Not Applicable
17 pyruvate Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 18-months Safety Follow-up Study of AADvac1, an Active Tau Vaccine for Alzheimer's Disease Completed NCT02031198 Phase 1 AADvac1
4 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
5 Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder Recruiting NCT03095170 Not Applicable
6 Behavioral Interventions to Prevent or Delay Dementia Active, not recruiting NCT02265757 Not Applicable
7 An Examination of the Use of Electrophysiological Brain Monitoring to Direct the Treatment of Mild Cognitive Impairment Not yet recruiting NCT03375151 Not Applicable

Search NIH Clinical Center for Amnestic Disorder

Cochrane evidence based reviews: amnesia

Genetic Tests for Amnestic Disorder

Anatomical Context for Amnestic Disorder

MalaCards organs/tissues related to Amnestic Disorder:

41
Brain, Pituitary

Publications for Amnestic Disorder

Articles related to Amnestic Disorder:

# Title Authors Year
1
Executive dysfunction in Korsakoff's syndrome: Time to revise the DSM criteria for alcohol-induced persisting amnestic disorder? ( 24946125 )
2009
2
Paroxetine treatment in alcohol amnestic disorder. ( 10334004 )
1999
3
Benzodiazepine-induced persisting amnestic disorder: are older adults at risk? ( 9573640 )
1998
4
Fluvoxamine treatment of alcoholic amnestic disorder. ( 7542052 )
1995
5
The course of alcohol amnestic disorder: a three-year follow-up study of clinical signs and social disabilities. ( 1414421 )
1992
6
Pituitary-adrenal responses to oCRH and central neuropeptide levels in alcohol amnestic disorder. ( 1651774 )
1991
7
Organic amnestic disorder: a long-term sequel after neuroleptic malignant syndrome. ( 2036482 )
1991
8
Effective pharmacotherapy of alcoholic amnestic disorder with fluvoxamine. Preliminary findings. ( 2472126 )
1989
9
Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder. ( 6848295 )
1983

Variations for Amnestic Disorder

Expression for Amnestic Disorder

Search GEO for disease gene expression data for Amnestic Disorder.

Pathways for Amnestic Disorder

Pathways related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 BDNF CREB1 HTR1A HTR3A HTR6 HTR7
2
Show member pathways
12.55 BDNF CREB1 FOS PSEN1
3
Show member pathways
12.49 BDNF CREB1 FOS PDYN
4 12.38 CNR1 CREB1 HTR1A PSEN1
5
Show member pathways
12.1 CREB1 HTR6 HTR7 PDYN
6 11.89 BDNF CNR1 CREB1 FOS
7 11.86 CNR1 HTR1A TSPO
8
Show member pathways
11.86 BDNF CREB1 FOS HTR1A HTR6
9 11.81 BDNF FOS PDYN
10
Show member pathways
11.77 HTR1A HTR6 HTR7
11
Show member pathways
11.77 BDNF CREB1 FOS PDYN
12 11.68 HTR1A HTR3A HTR6 HTR7
13 11.57 BDNF CHAT CREB1 HTR1A HTR3A
14 11.37 ACHE CREB1 FOS
15
Show member pathways
11.03 ACHE BCHE
16 10.99 ACHE BCHE CHAT
17 10.97 CREB1 FOS
18
Show member pathways
10.93 ACHE CHAT
19 10.82 CREB1 FOS
20 10.71 CREB1 HTR6 HTR7
21 10.67 BDNF CREB1
22 10.59 ACHE CHAT
23 10.37 HTR1A HTR3A HTR6 HTR7
24 10.34 ACHE CHAT

GO Terms for Amnestic Disorder

Cellular components related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.43 BDNF HTR1A HTR6 HTR7 PDYN PSEN1
2 axon GO:0030424 9.1 BDNF CNR1 CREB1 EIF4G2 HTR3A PSEN1

Biological processes related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.84 ACHE HTR1A LGI1 TSPO
2 positive regulation of apoptotic process GO:0043065 9.81 CNR1 CREB1 PSEN1 TSPO
3 response to drug GO:0042493 9.76 BCHE CREB1 FOS TSPO
4 aging GO:0007568 9.62 CNR1 CREB1 FOS TSPO
5 regulation of synaptic transmission, glutamatergic GO:0051966 9.58 CNR1 PSEN1
6 positive regulation of dendritic spine development GO:0060999 9.57 EIF4G2 PSEN1
7 cellular response to zinc ion GO:0071294 9.56 CREB1 TSPO
8 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.55 HTR1A HTR6
9 chemical synaptic transmission GO:0007268 9.55 HTR1A HTR3A HTR6 HTR7 PDYN
10 positive regulation of osteoclast differentiation GO:0045672 9.52 CREB1 FOS
11 vasoconstriction GO:0042310 9.49 HTR1A HTR7
12 locomotion GO:0040011 9.48 BDNF PSEN1
13 neurotransmitter biosynthetic process GO:0042136 9.43 ACHE CHAT
14 cerebral cortex cell migration GO:0021795 9.4 HTR6 PSEN1
15 amyloid precursor protein metabolic process GO:0042982 9.37 ACHE PSEN1
16 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.26 HTR1A HTR7
17 memory GO:0007613 9.26 BDNF CNR1 CREB1 PSEN1
18 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR6 HTR7

Molecular functions related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.37 CREB1 FOS
2 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR6 HTR7
3 cholinesterase activity GO:0004104 9.32 ACHE BCHE
4 acetylcholinesterase activity GO:0003990 9.26 ACHE BCHE
5 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR6 HTR7
6 serotonin binding GO:0051378 8.8 HTR1A HTR3A HTR7

Sources for Amnestic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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