Aliases & Classifications for Amnestic Disorder

MalaCards integrated aliases for Amnestic Disorder:

Name: Amnestic Disorder 12 15 74
Amnesia 12 77 56 45 15 17 74
Korsakoff's Psychosis or Syndrome 12
Amnestic Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10914
ICD9CM 36 294.0
MeSH 45 D000647
NCIt 51 C2867
ICD10 34 R41.3

Summaries for Amnestic Disorder

Disease Ontology : 12 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.

MalaCards based summary : Amnestic Disorder, also known as amnesia, is related to dissociative amnesia and wernicke-korsakoff syndrome, and has symptoms including mental and behavioral signs and symptoms, forgetful and memory loss. An important gene associated with Amnestic Disorder is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Vaccines and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Amnesia is a deficit in memory caused by brain damage or disease. Amnesia can also be caused temporarily... more...

Related Diseases for Amnestic Disorder

Diseases related to Amnestic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 dissociative amnesia 34.6 HTR1A PDYN
2 wernicke-korsakoff syndrome 32.0 ACHE CHAT
3 anterograde amnesia 32.0 EIF4G2 HTR1A
4 agnosia 31.4 CNR1 HTR7 OPRK1 OPRM1 PDYN
5 mental depression 29.6 BDNF HTR1A HTR7
6 temporal lobe epilepsy 29.5 BDNF HTR1A LGI1 PDYN TSPO
7 anxiety 29.5 BDNF CNR1 HTR1A HTR3A TSPO
8 major depressive disorder 29.3 BDNF CREB1 HTR1A HTR3A
9 migraine with or without aura 1 29.2 CNR1 HTR1A HTR3A HTR7
10 schizophrenia 28.8 BDNF CNR1 HTR1A HTR3A HTR7
11 parkinson disease, late-onset 28.7 ACHE BDNF CHAT CNR1 HTR1A PDYN
12 alcohol dependence 28.0 BDNF CNR1 HTR1A HTR3A OPRD1 OPRK1
13 hhv-6 encephalitis 11.5
14 aphasia 11.4
15 transient global amnesia 11.1
16 retrograde amnesia 11.1
17 morvan's fibrillary chorea 11.0
18 korsakoff's amnesic syndrome 11.0
19 cerebral beriberi 11.0
20 brain injury 10.6
21 traumatic brain injury 10.5
22 encephalitis 10.5
23 dementia 10.5
24 head injury 10.5
25 alzheimer disease 10.4
26 epilepsy 10.4
27 schizophrenia 5 10.4 HTR1A HTR3A
28 depression 10.3
29 ischemia 10.2
30 social phobia 10.2 HTR1A HTR3A
31 hypoxia 10.2
32 panic disorder 10.2 HTR1A HTR3A TSPO
33 phobic disorder 10.2 HTR1A OPRK1
34 opioid abuse 10.2 OPRM1 PDYN
35 limbic encephalitis 10.2
36 constipation 10.2 CHAT HTR3A OPRM1
37 herpes simplex 10.2
38 psychosexual disorder 10.2 HTR1A HTR7
39 premature ejaculation 10.2 HTR1A HTR3A
40 multiple personality disorder 10.1
41 encephalopathy 10.1
42 headache 10.1
43 neonatal abstinence syndrome 10.1 OPRD1 OPRK1 OPRM1
44 nervous system disease 10.1 ACHE BDNF CHAT
45 opioid addiction 10.1 OPRD1 OPRK1 OPRM1
46 psychotic disorder 10.1 BDNF HTR1A HTR3A
47 ocular motor apraxia 10.1
48 aging 10.1
49 frontotemporal dementia 10.1
50 cortical blindness 10.1

Comorbidity relations with Amnestic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Amnestic Disorder:



Diseases related to Amnestic Disorder

Symptoms & Phenotypes for Amnestic Disorder

UMLS symptoms related to Amnestic Disorder:


mental and behavioral signs and symptoms, forgetful, memory loss

MGI Mouse Phenotypes related to Amnestic Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
2 homeostasis/metabolism MP:0005376 10.21 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
3 growth/size/body region MP:0005378 10.14 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
4 mortality/aging MP:0010768 10.03 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
5 integument MP:0010771 9.97 BDNF CNR1 HTR3A HTR7 LGI1 OPRD1
6 nervous system MP:0003631 9.97 ACHE BDNF CHAT CNR1 CREB1 HTR1A
7 digestive/alimentary MP:0005381 9.91 BDNF CHAT CNR1 OPRK1 OPRM1 PDYN
8 no phenotypic analysis MP:0003012 9.5 ACHE BDNF CNR1 HTR1A OPRD1 OPRM1
9 reproductive system MP:0005389 9.28 ACHE BDNF CHAT CNR1 CREB1 HTR3A

Drugs & Therapeutics for Amnestic Disorder

Drugs for Amnestic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1
2 Antibodies Phase 1
3 Immunoglobulins Phase 1
4
tannic acid Approved Not Applicable 1401-55-4
5
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
6
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
7
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 70-16-6, 59-43-8 1130
8 pyruvate Not Applicable
9 Vitamins Not Applicable
10 Thiamin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 18-months Safety Follow-up Study of AADvac1, an Active Tau Vaccine for Alzheimer's Disease Completed NCT02031198 Phase 1 AADvac1
2 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
3 Behavioral Interventions to Prevent or Delay Dementia Completed NCT02265757 Not Applicable
4 Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder Recruiting NCT03095170 Not Applicable
5 An Examination of the Use of Electrophysiological Brain Monitoring to Direct the Treatment of Mild Cognitive Impairment Not yet recruiting NCT03375151 Not Applicable

Search NIH Clinical Center for Amnestic Disorder

Cochrane evidence based reviews: amnesia

Genetic Tests for Amnestic Disorder

Anatomical Context for Amnestic Disorder

MalaCards organs/tissues related to Amnestic Disorder:

42
Brain, Temporal Lobe, Testes, Cortex, Amygdala, Heart, Prefrontal Cortex

Publications for Amnestic Disorder

Articles related to Amnestic Disorder:

(show top 50) (show all 3008)
# Title Authors Year
1
Saturday night retinopathy and anterograde amnesia due to fentanyl overdose. ( 31041135 )
2019
2
Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. ( 30863075 )
2019
3
Addressing post-traumatic amnesia - recommendations for improving patient lives after brain injury. ( 30768563 )
2019
4
Transient global amnesia and transient cortical blindness secondary to contrast induced encephalopathy after renal artery angiography. ( 30929878 )
2019
5
Transient epileptic amnesia accompanied by prodromal symptoms of dementia with Lewy bodies: the second case report in the literature. ( 30773739 )
2019
6
Anti-N-methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia. ( 30992284 )
2019
7
Hippocampal network abnormalities explain amnesia after VGKCC-Ab related autoimmune limbic encephalitis. ( 31072956 )
2019
8
NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia. ( 30686545 )
2019
9
Childhood amnesia and post-traumatic stress disorder: Attachment vs default mode and executive function. ( 30681005 )
2019
10
Double whammy: sex-related headache and amnesia. ( 30927160 )
2019
11
Risk of intracranial complications in minor head injury: the role of loss of consciousness and posttraumatic amnesia in a multicenter observational study. ( 30860435 )
2019
12
Restructuring Blank Spaces: The Role of Cognitive-Behavioral Interventions for Two Patients With Post-traumatic Amnesia After Severe Traumatic Brain Injury. ( 30137456 )
2019
13
Economic Evaluation of Activities of Daily Living Retraining During Posttraumatic Amnesia for Inpatient Rehabilitation Following Severe Traumatic Brain Injury. ( 30273549 )
2019
14
Burden of Care Implications and Association of Intracranial Hypertension With Extremely Severe Post-traumatic Amnesia After Traumatic Brain Injury: A 5-Year Retrospective Longitudinal Study. ( 30761071 )
2019
15
Length of post-traumatic amnesia and its prediction of neuropsychological outcome following severe to extremely severe traumatic brain injury in a litigating sample. ( 31046471 )
2019
16
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. ( 29877098 )
2019
17
Transient Global Amnesia as the Sole Presentation of an Acute Stroke in the Left Cingulate Gyrus. ( 30915247 )
2019
18
Enhanced cortisol secretion in acute transient global amnesia. ( 30193207 )
2019
19
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. ( 30305003 )
2019
20
Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report. ( 30678717 )
2019
21
Myocardial injury in transient global amnesia: a case-control study. ( 30706590 )
2019
22
Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery. ( 30709618 )
2019
23
Transient global amnesia: an intriguing yet benign disturbance. ( 30758435 )
2019
24
Transient global amnesia: clinical features and prognostic factors suggesting recurrence. ( 30758436 )
2019
25
Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation. ( 30804883 )
2019
26
Alcohol-Induced Amnesia and Personalized Drinking Feedback: Blackouts Predict Intervention Response. ( 30661564 )
2019
27
Gesture height reflects common ground status even in patients with amnesia. ( 30677621 )
2019
28
Hippocampal contributions to value-based learning: Converging evidence from fMRI and amnesia. ( 30767129 )
2019
29
Isorhamnetin Enhanced Cortico-Hippocampal Learning and Memory Capability in Mice with Scopolamine-Induced Amnesia: Role of Antioxidant Defense, Cholinergic and BDNF Signaling. ( 30772273 )
2019
30
Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. ( 30804787 )
2019
31
Feigned Amnesia as a Defense Reaction. ( 30806681 )
2019
32
Effects of Korsakoff Amnesia on performance and symptom validity testing. ( 30848959 )
2019
33
Saccadic selection does not eliminate attribute amnesia. ( 30883172 )
2019
34
Little evidence for fast mapping in adults with developmental amnesia. ( 30894071 )
2019
35
Does attribute amnesia occur with the presentation of complex, meaningful stimuli? The answer is, "it depends". ( 30924060 )
2019
36
Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF. ( 30949953 )
2019
37
Low-dose ethanol ameliorates amnesia induced by a brief seizure model: the role of NMDA signaling. ( 30967097 )
2019
38
The Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, but not Cathodal, tDCS on Streptozocin-Induced Amnesia. ( 31029071 )
2019
39
Capturing real-life forgetting in transient epileptic amnesia via an incidental memory test. ( 29329640 )
2019
40
Effects of 5-HT5A receptor blockade on amnesia or forgetting. ( 29330003 )
2019
41
Infantile Amnesia Is Related to Developmental Immaturity of the Maintenance Mechanisms for Long-Term Potentiation. ( 29804230 )
2019
42
Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat. ( 30009706 )
2019
43
Randomized Clinical Trial Comparing Procedural Amnesia and Respiratory Depression Between Moderate and Deep Sedation With Propofol in the Emergency Department. ( 30098230 )
2019
44
Repetition priming in amnesia: Distinguishing associative learning at different levels of abstraction. ( 30485796 )
2019
45
Preliminary validation study of the Sydney Post-Traumatic Amnesia Scale (SYPTAS) in children with traumatic brain injury aged 4 to 7 years. ( 29058469 )
2019
46
Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. ( 30919246 )
2019
47
Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation. ( 31049133 )
2019
48
Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia. ( 31033742 )
2019
49
Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures. ( 31039379 )
2019
50
Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice. ( 31049081 )
2019

Variations for Amnestic Disorder

Expression for Amnestic Disorder

Search GEO for disease gene expression data for Amnestic Disorder.

Pathways for Amnestic Disorder

Pathways related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 CNR1 GABRR3 HTR1A HTR7 OPRD1 OPRK1
2 12.29 CNR1 CREB1 HTR1A OPRM1
3 11.87 BDNF CNR1 CREB1
4 11.77 CNR1 HTR1A TSPO
5
Show member pathways
11.72 BDNF CREB1 PDYN
6 11.67 HTR1A HTR3A HTR7
7 11.23 BDNF CREB1 OPRK1
8 11.23 BDNF CHAT CREB1 HTR1A HTR3A
9 11 ACHE CHAT
10 10.98 BDNF CREB1
11
Show member pathways
10.87 ACHE CHAT
12 10.79 CREB1 HTR7
13 10.78 HTR1A HTR3A HTR7
14 10.55 BDNF CREB1
15 10.45 ACHE CHAT
16 10.17 ACHE CHAT

GO Terms for Amnestic Disorder

Cellular components related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 CNR1 GABRR3 HTR1A HTR3A HTR7 OPRD1
2 synapse GO:0045202 9.83 ACHE GABRR3 HTR3A LGI1 OPRK1
3 dendrite GO:0030425 9.63 BDNF HTR1A HTR7 OPRK1 OPRM1 PDYN
4 axon terminus GO:0043679 9.58 OPRD1 OPRK1 PDYN
5 integral component of postsynaptic membrane GO:0099055 9.54 HTR3A OPRK1 OPRM1
6 synaptic cleft GO:0043083 9.46 ACHE LGI1
7 axon GO:0030424 9.43 BDNF CNR1 CREB1 EIF4G2 HTR3A OPRM1
8 spine apparatus GO:0097444 9.32 OPRD1 OPRM1
9 integral component of presynaptic membrane GO:0099056 9.02 CNR1 HTR3A OPRD1 OPRK1 OPRM1

Biological processes related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 CNR1 CREB1 GABRR3 HTR1A HTR3A HTR7
2 memory GO:0007613 9.76 BDNF CNR1 CREB1
3 response to ethanol GO:0045471 9.76 CNR1 HTR3A OPRK1 OPRM1
4 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.73 OPRD1 OPRK1 OPRM1
5 cellular response to growth factor stimulus GO:0071363 9.72 CREB1 HTR3A OPRD1
6 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.71 OPRD1 OPRK1 OPRM1
7 sensory perception of pain GO:0019233 9.7 CNR1 OPRK1 OPRM1
8 regulation of sensory perception of pain GO:0051930 9.67 OPRD1 OPRK1 OPRM1
9 neuropeptide signaling pathway GO:0007218 9.67 OPRD1 OPRK1 OPRM1 PDYN
10 response to morphine GO:0043278 9.65 CNR1 OPRK1 OPRM1
11 phosphatidylcholine biosynthetic process GO:0006656 9.63 ACHE CHAT
12 cellular response to zinc ion GO:0071294 9.62 CREB1 TSPO
13 cell proliferation GO:0008283 9.62 ACHE HTR1A
14 vasoconstriction GO:0042310 9.61 HTR1A HTR7
15 estrous cycle GO:0044849 9.61 OPRK1 OPRM1
16 neurotransmitter biosynthetic process GO:0042136 9.6 ACHE CHAT
17 sensory perception GO:0007600 9.59 OPRK1 OPRM1
18 behavior GO:0007610 9.58 HTR1A OPRK1
19 eating behavior GO:0042755 9.58 OPRD1 OPRK1 OPRM1
20 serotonin receptor signaling pathway GO:0007210 9.57 HTR1A HTR3A
21 response to cocaine GO:0042220 9.46 CNR1 HTR3A OPRK1 OPRM1
22 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.43 OPRK1 OPRM1
23 opioid receptor signaling pathway GO:0038003 9.43 OPRD1 OPRK1 OPRM1
24 chemical synaptic transmission GO:0007268 9.43 GABRR3 HTR1A HTR3A HTR7 OPRK1 PDYN
25 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.02 CNR1 HTR1A HTR7 OPRD1 OPRM1
26 G protein-coupled receptor signaling pathway GO:0007186 10.05 CNR1 HTR1A HTR7 OPRD1 OPRK1 OPRM1

Molecular functions related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.63 CNR1 HTR1A HTR7 OPRD1 OPRK1 OPRM1
2 serotonin binding GO:0051378 9.32 HTR1A HTR3A
3 receptor serine/threonine kinase binding GO:0033612 9.26 OPRD1 OPRK1
4 neuropeptide binding GO:0042923 9.13 OPRD1 OPRK1 OPRM1
5 opioid receptor activity GO:0004985 8.8 OPRD1 OPRK1 OPRM1

Sources for Amnestic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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