Aliases & Classifications for Amnestic Disorder

MalaCards integrated aliases for Amnestic Disorder:

Name: Amnestic Disorder 12 15 73
Amnesia 12 76 55 44 15 73
Korsakoff's Psychosis or Syndrome 12
Amnestic Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10914
ICD10 33 R41.3
ICD9CM 35 294.0
MeSH 44 D000647
NCIt 50 C2867

Summaries for Amnestic Disorder

Disease Ontology : 12 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.

MalaCards based summary : Amnestic Disorder, also known as amnesia, is related to dissociative amnesia and agnosia, and has symptoms including memory loss, mental and behavioral signs and symptoms and forgetful. An important gene associated with Amnestic Disorder is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are CREB Pathway and Neuroscience. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Amnesia is a deficit in memory caused by brain damage, disease, or psychological trauma. Amnesia can... more...

Related Diseases for Amnestic Disorder

Diseases related to Amnestic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 dissociative amnesia 34.4 PDYN HTR1A
2 agnosia 32.3 PDYN HTR7 CNR1
3 anterograde amnesia 31.8 HTR1A EIF4G2
4 wernicke-korsakoff syndrome 31.8 CHAT ACHE
5 dementia 29.9 ACHE PSEN1 CHAT BDNF BCHE
6 alzheimer disease 29.7 PSEN1 CHAT BDNF BCHE ACHE
7 temporal lobe epilepsy 29.6 TSPO PDYN LGI1 HTR1A BDNF
8 migraine with or without aura 1 29.6 HTR7 HTR3A HTR1A CNR1
9 anxiety 29.6 TSPO HTR3A HTR1A CNR1 BDNF
10 major depressive disorder 29.5 HTR3A HTR1A CREB1 BDNF
11 post-traumatic stress disorder 29.5 PREP CNR1 BDNF
12 bipolar disorder 29.4 HTR3A HTR1A CREB1 BDNF
13 amyotrophic lateral sclerosis 1 29.2 TSPO PSEN1 CNR1 CHAT BDNF
14 parkinson disease, late-onset 28.8 PDYN HTR1A CNR1 CHAT BDNF BCHE
15 hhv-6 encephalitis 11.5
16 aphasia 11.3
17 transient global amnesia 11.0
18 retrograde amnesia 11.0
19 korsakoff's amnesic syndrome 11.0
20 cerebral beriberi 11.0
21 brain injury 10.5
22 traumatic brain injury 10.5
23 encephalitis 10.4
24 epilepsy 10.3
25 ischemia 10.2
26 head injury 10.2
27 social phobia 10.2 HTR3A HTR1A
28 depression 10.2
29 premature ejaculation 10.2 HTR3A HTR1A
30 cyclic vomiting syndrome 10.2 HTR3A CNR1
31 limbic encephalitis 10.2
32 childhood disintegrative disease 10.1 LGI1 BDNF
33 multiple personality disorder 10.1
34 herpes simplex 10.1
35 cannabis abuse 10.1 CNR1 BDNF
36 heroin dependence 10.1 PDYN BDNF
37 psychosexual disorder 10.1 HTR7 HTR1A
38 psychotic disorder 10.1 HTR3A HTR1A BDNF
39 autoimmune encephalitis 10.1 LGI1 CNR1
40 ocular dominance 10.1 CREB1 CHAT BDNF
41 kleptomania 10.1 HTR7 HTR1A
42 toxic encephalopathy 10.1 CREB1 BDNF ACHE
43 focal epilepsy 10.1 TSPO PDYN LGI1
44 motion sickness 10.1 HTR7 HTR3A HTR1A
45 brunner syndrome 10.1 HTR7 HTR3A HTR1A
46 generalized anxiety disorder 10.1 TSPO HTR3A HTR1A BDNF
47 mood disorder 10.1 HTR1A CREB1 BDNF
48 panic disorder 10.1 TSPO HTR3A HTR1A BDNF
49 frontotemporal dementia 10.0
50 cortical blindness 10.0

Comorbidity relations with Amnestic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Amnestic Disorder:



Diseases related to Amnestic Disorder

Symptoms & Phenotypes for Amnestic Disorder

UMLS symptoms related to Amnestic Disorder:


memory loss, mental and behavioral signs and symptoms, forgetful

MGI Mouse Phenotypes related to Amnestic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.28 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
2 homeostasis/metabolism MP:0005376 10.2 ACHE BCHE BDNF CHAT CNR1 CREB1
3 growth/size/body region MP:0005378 10.18 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
4 mortality/aging MP:0010768 10 ACHE BCHE BDNF CHAT CNR1 CREB1
5 adipose tissue MP:0005375 9.91 ACHE CNR1 HTR6 LGI1 PDYN PREP
6 integument MP:0010771 9.8 BDNF CNR1 HTR3A HTR7 LGI1 PDYN
7 nervous system MP:0003631 9.73 ACHE BDNF CHAT CNR1 CREB1 HTR1A
8 reproductive system MP:0005389 9.28 ACHE BCHE BDNF CHAT CNR1 CREB1

Drugs & Therapeutics for Amnestic Disorder

Drugs for Amnestic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
3 Thiamin Phase 4,Phase 2,Phase 3,Not Applicable
4 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
5 Vitamin B Complex Phase 4,Phase 2,Phase 3
6 Vitamin B9 Phase 4,Phase 2,Phase 3
7 Trace Elements Phase 4,Phase 2,Phase 3
8 Micronutrients Phase 4,Phase 2,Phase 3
9 Folate Phase 4,Phase 2,Phase 3
10
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
11
Ethanol Approved Phase 2, Phase 3 64-17-5 702
12 Anticonvulsants Phase 2, Phase 3
13 calcium channel blockers Phase 2, Phase 3
14 Calcium, Dietary Phase 2, Phase 3
15 Anesthetics Phase 2, Phase 3
16 Analgesics Phase 2, Phase 3
17 Peripheral Nervous System Agents Phase 2, Phase 3
18 Central Nervous System Depressants Phase 2, Phase 3
19 Tocolytic Agents Phase 2, Phase 3
20 Anti-Arrhythmia Agents Phase 2, Phase 3
21 Antibodies Phase 1
22 Vaccines Phase 1
23 Immunoglobulins Phase 1
24 tannic acid Approved Not Applicable
25
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
26
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
27 pyruvate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 18-months Safety Follow-up Study of AADvac1, an Active Tau Vaccine for Alzheimer's Disease Completed NCT02031198 Phase 1 AADvac1
4 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
5 Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder Recruiting NCT03095170 Not Applicable
6 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
7 Behavioral Interventions to Prevent or Delay Dementia Active, not recruiting NCT02265757 Not Applicable
8 An Examination of the Use of Electrophysiological Brain Monitoring to Direct the Treatment of Mild Cognitive Impairment Not yet recruiting NCT03375151 Not Applicable

Search NIH Clinical Center for Amnestic Disorder

Cochrane evidence based reviews: amnesia

Genetic Tests for Amnestic Disorder

Anatomical Context for Amnestic Disorder

MalaCards organs/tissues related to Amnestic Disorder:

41
Brain, Testes, Temporal Lobe, Liver, Breast, Amygdala, Cortex

Publications for Amnestic Disorder

Articles related to Amnestic Disorder:

(show top 50) (show all 663)
# Title Authors Year
1
Enhanced cortisol secretion in acute transient global amnesia. ( 30193207 )
2019
2
Repetition priming in amnesia: Distinguishing associative learning at different levels of abstraction. ( 30485796 )
2019
3
Dural Arteriovenous Fistula Causing Recurrent Transient Global Amnesia. ( 30245773 )
2018
4
Restructuring Blank Spaces: The Role of Cognitive-Behavioral Interventions for Two Patients With Post-traumatic Amnesia After Severe Traumatic Brain Injury. ( 30137456 )
2018
5
Progressively analogous evidence of covert face recognition from functional magnetic resonance imaging and skin conductance responses studies involving a patient with dissociative amnesia. ( 30044019 )
2018
6
State-Dependent Memory: Neurobiological Advances and Prospects for Translation to Dissociative Amnesia. ( 30429781 )
2018
7
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. ( 30443620 )
2018
8
Retrograde amnesia after intravenous sedation and general anaesthesia in a dental hospital. ( 30029983 )
2018
9
Postictal pure retrograde amnesia: Response. ( 30442449 )
2018
10
Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia. ( 30460616 )
2018
11
Touching the void - First and third person perspectives in two cases of autobiographical amnesia linked to temporal lobe epilepsy. ( 28711591 )
2018
12
Transient global amnesia: Minor inconvenience or early warning sign? ( 30069134 )
2018
13
Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event. ( 30094523 )
2018
14
Clinics in diagnostic imaging (188). Transient global amnesia (TGA). ( 30109353 )
2018
15
Some thoughts about concomitant transient global amnesia and takotsubo syndrome. ( 30151690 )
2018
16
Medical Procedure-Related Transient Global Amnesia. ( 30205365 )
2018
17
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. ( 30305003 )
2018
18
Risk factors of transient global amnesia: Three case reports. ( 30313071 )
2018
19
Vertebral artery loop in a case of recurrent transient global amnesia. ( 30504067 )
2018
20
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient. ( 30530409 )
2018
21
Economic Evaluation of Activities of Daily Living Retraining During Posttraumatic Amnesia for Inpatient Rehabilitation Following Severe Traumatic Brain Injury. ( 30273549 )
2018
22
A case of recurrent transient global amnesia: don't forget the hippocampal punctuate diffusion restriction. ( 29977579 )
2018
23
Letter by Mugikura and Takahashi Regarding Article, "Ischemic Amnesia: Causes and Outcome". ( 29212741 )
2018
24
Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model. ( 29260547 )
2018
25
The political biography of an earthquake - aftermath and Amnesia in Gujarat, India. ( 29280675 )
2018
26
Effects of 5-HT5A receptor blockade on amnesia or forgetting. ( 29330003 )
2018
27
Amnesia due to the Injury of Papez Circuit Following Isolated Fornix Column Infarction. ( 29395646 )
2018
28
The value of the identification of predisposing factors for post-traumatic amnesia in management of mild traumatic brain injury. ( 29400569 )
2018
29
Ebselen inhibits the activity of acetylcholinesterase globular isoform G4 in vitro and attenuates scopolamine-induced amnesia in mice. ( 29405440 )
2018
30
Isolated persistent acute global amnesia after acute abuse of 3,4-methylenedioxy-methamphetamine (MDMA). ( 29406963 )
2018
31
Preserved re-experience of discrete emotions: Amnesia and executive function. ( 29411941 )
2018
32
Can implicit measures detect source information in crime-related amnesia? ( 29457541 )
2018
33
Using attribute amnesia to test the limits of hyper-binding and associative deficits in working memory. ( 29494187 )
2018
34
Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia. ( 29494759 )
2018
35
NMDA or 5-HT receptor antagonists impair memory reconsolidation and induce various types of amnesia. ( 29499285 )
2018
36
Hand gestures support word learning in patients with hippocampal amnesia. ( 29506316 )
2018
37
Yuk-Mi-Jihwang-Tang, a Traditional Korean Multiple Herbal Formulae, Improves Hippocampal Memory on Scopolamine Injection-Induced Amnesia Model of C57BL/6 Mice. ( 29507588 )
2018
38
Activities of daily living retraining and goal attainment during posttraumatic amnesia. ( 29516771 )
2018
39
No evidence for unethical amnesia for imagined actions: A failed replication and extension. ( 29532400 )
2018
40
Streams of Unconsciousness I: Amnesia Reflected in Lethe. ( 29533296 )
2018
41
Pharmacologically induced amnesia for learned fear is time and sleep dependent. ( 29615619 )
2018
42
Classic and recent advances in understanding amnesia. ( 29623196 )
2018
43
Acute amnesia associated with damaged fiber tracts following anterior fornix infarction. ( 29632111 )
2018
44
Forgetting the new locations of one's keys: spatial-memory interference in Korsakoff's amnesia. ( 29680910 )
2018
45
Phencyclidine and Scopolamine for Modeling Amnesia in Rodents: Direct Comparison with the Use of Barnes Maze Test and Contextual Fear Conditioning Test in Mice. ( 29680979 )
2018
46
Semantic memory in developmental amnesia. ( 29715544 )
2018
47
Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice. ( 29716575 )
2018
48
Feigning Amnesia Moderately Impairs Memory for a Mock Crime Video. ( 29760675 )
2018
49
The effect of CA1 dopaminergic system on amnesia induced by harmane in mice. ( 29767374 )
2018
50
'Lost My Way' - Transient Topographic Amnesia: A Bizarre Manifestation of Migraine. ( 30532375 )
2018

Variations for Amnestic Disorder

Expression for Amnestic Disorder

Search GEO for disease gene expression data for Amnestic Disorder.

Pathways for Amnestic Disorder

Pathways related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 BDNF CREB1 HTR1A HTR3A HTR6 HTR7
2 12.35 CNR1 CREB1 HTR1A PSEN1
3
Show member pathways
12.03 CREB1 HTR6 HTR7 PDYN
4
Show member pathways
11.97 BDNF CREB1 HTR1A HTR6
5 11.9 BDNF CNR1 CREB1
6 11.83 CNR1 HTR1A TSPO
7
Show member pathways
11.77 BDNF CREB1 PDYN
8
Show member pathways
11.73 HTR1A HTR6 HTR7
9 11.62 HTR1A HTR3A HTR6 HTR7
10 11.57 BDNF CHAT CREB1 HTR1A HTR3A
11 11.02 BDNF CREB1
12
Show member pathways
10.99 ACHE BCHE
13 10.94 ACHE BCHE CHAT
14
Show member pathways
10.9 ACHE CHAT
15 10.62 BDNF CREB1
16 10.61 CREB1 HTR6 HTR7
17 10.54 ACHE CHAT
18 10.37 HTR1A HTR3A HTR6 HTR7
19 10.28 ACHE CHAT

GO Terms for Amnestic Disorder

Cellular components related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 CNR1 HTR1A HTR3A HTR6 HTR7 PSEN1
2 dendrite GO:0030425 9.43 BDNF HTR1A HTR6 HTR7 PDYN PSEN1
3 integral component of presynaptic membrane GO:0099056 9.33 CNR1 HTR3A PSEN1
4 synaptic cleft GO:0043083 9.26 ACHE LGI1
5 axon GO:0030424 9.1 BDNF CNR1 CREB1 EIF4G2 HTR3A PSEN1

Biological processes related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.8 ACHE HTR1A LGI1 TSPO
2 positive regulation of apoptotic process GO:0043065 9.78 CNR1 CREB1 PSEN1 TSPO
3 phosphatidylcholine biosynthetic process GO:0006656 9.55 ACHE CHAT
4 chemical synaptic transmission GO:0007268 9.55 HTR1A HTR3A HTR6 HTR7 PDYN
5 regulation of synaptic transmission, glutamatergic GO:0051966 9.54 CNR1 PSEN1
6 cellular response to zinc ion GO:0071294 9.52 CREB1 TSPO
7 positive regulation of dendritic spine development GO:0060999 9.51 EIF4G2 PSEN1
8 vasoconstriction GO:0042310 9.46 HTR1A HTR7
9 neurotransmitter biosynthetic process GO:0042136 9.43 ACHE CHAT
10 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.43 HTR1A HTR6 HTR7
11 amyloid precursor protein metabolic process GO:0042982 9.4 ACHE PSEN1
12 cerebral cortex cell migration GO:0021795 9.37 HTR6 PSEN1
13 serotonin receptor signaling pathway GO:0007210 9.32 HTR1A HTR3A
14 memory GO:0007613 9.26 BDNF CNR1 CREB1 PSEN1
15 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR6 HTR7

Molecular functions related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR6 HTR7
2 serotonin binding GO:0051378 9.32 HTR1A HTR3A
3 cholinesterase activity GO:0004104 9.26 ACHE BCHE
4 G protein-coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR6 HTR7
5 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Amnestic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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