Aliases & Classifications for Amnestic Disorder

MalaCards integrated aliases for Amnestic Disorder:

Name: Amnestic Disorder 12 15 74
Amnesia 12 77 56 45 15 17 74
Korsakoff's Psychosis or Syndrome 12
Amnestic Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10914
ICD9CM 36 294.0
MeSH 45 D000647
NCIt 51 C2867
ICD10 34 R41.3

Summaries for Amnestic Disorder

Disease Ontology : 12 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.

MalaCards based summary : Amnestic Disorder, also known as amnesia, is related to dissociative amnesia and anterograde amnesia, and has symptoms including memory loss, mental and behavioral signs and symptoms and forgetful. An important gene associated with Amnestic Disorder is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Immunoglobulins and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Amnesia is a deficit in memory caused by brain damage, disease, or psychological trauma. Amnesia can... more...

Related Diseases for Amnestic Disorder

Diseases related to Amnestic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 dissociative amnesia 34.6 HTR1A PDYN
2 anterograde amnesia 32.0 EIF4G2 HTR1A
3 wernicke-korsakoff syndrome 31.9 ACHE CHAT
4 agnosia 31.4 CNR1 HTR7 OPRK1 OPRM1 PDYN
5 temporal lobe epilepsy 29.5 BDNF HTR1A LGI1 PDYN TSPO
6 anxiety 29.4 BDNF CNR1 HTR1A HTR3A TSPO
7 migraine with or without aura 1 29.2 CNR1 HTR1A HTR3A HTR7
8 major depressive disorder 29.2 BDNF CREB1 HTR1A HTR3A
9 schizophrenia 28.7 BDNF CNR1 HTR1A HTR3A HTR7
10 parkinson disease, late-onset 28.6 ACHE BDNF CHAT CNR1 HTR1A PDYN
11 alcohol dependence 28.0 BDNF CNR1 HTR1A HTR3A OPRD1 OPRK1
12 hhv-6 encephalitis 11.5
13 aphasia 11.4
14 transient global amnesia 11.1
15 retrograde amnesia 11.1
16 morvan's fibrillary chorea 11.0
17 korsakoff's amnesic syndrome 11.0
18 cerebral beriberi 11.0
19 brain injury 10.6
20 traumatic brain injury 10.5
21 encephalitis 10.5
22 dementia 10.5
23 head injury 10.5
24 alzheimer disease 10.4
25 epilepsy 10.4
26 schizophrenia 5 10.3 HTR1A HTR3A
27 depression 10.3
28 ischemia 10.2
29 social phobia 10.2 HTR1A HTR3A
30 panic disorder 10.2 HTR1A HTR3A TSPO
31 hypoxia 10.2
32 phobic disorder 10.2 HTR1A OPRK1
33 opioid abuse 10.2 OPRM1 PDYN
34 constipation 10.2 CHAT HTR3A OPRM1
35 herpes simplex 10.2
36 limbic encephalitis 10.2
37 psychosexual disorder 10.2 HTR1A HTR7
38 premature ejaculation 10.1 HTR1A HTR3A
39 multiple personality disorder 10.1
40 neonatal abstinence syndrome 10.1 OPRD1 OPRK1 OPRM1
41 opioid addiction 10.1 OPRD1 OPRK1 OPRM1
42 motion sickness 10.1 HTR1A HTR3A HTR7
43 aging 10.1
44 frontotemporal dementia 10.1
45 seizure disorder 10.1
46 whiplash 10.1
47 encephalopathy 10.1
48 headache 10.1
49 nervous system disease 10.1 ACHE BDNF CHAT
50 brunner syndrome 10.1 HTR1A HTR3A HTR7

Comorbidity relations with Amnestic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Amnestic Disorder:



Diseases related to Amnestic Disorder

Symptoms & Phenotypes for Amnestic Disorder

UMLS symptoms related to Amnestic Disorder:


memory loss, mental and behavioral signs and symptoms, forgetful

MGI Mouse Phenotypes related to Amnestic Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
2 homeostasis/metabolism MP:0005376 10.21 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
3 growth/size/body region MP:0005378 10.14 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
4 mortality/aging MP:0010768 10.03 ACHE BDNF CHAT CNR1 CREB1 EIF4G2
5 integument MP:0010771 9.97 BDNF CNR1 HTR3A HTR7 LGI1 OPRD1
6 nervous system MP:0003631 9.97 ACHE BDNF CHAT CNR1 CREB1 HTR1A
7 digestive/alimentary MP:0005381 9.91 BDNF CHAT CNR1 OPRK1 OPRM1 PDYN
8 no phenotypic analysis MP:0003012 9.5 ACHE BDNF CNR1 HTR1A OPRD1 OPRM1
9 reproductive system MP:0005389 9.28 ACHE BDNF CHAT CNR1 CREB1 HTR3A

Drugs & Therapeutics for Amnestic Disorder

Drugs for Amnestic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1
2 Vaccines Phase 1
3 Antibodies Phase 1
4
tannic acid Approved Not Applicable 1401-55-4
5
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
6
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
7
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 59-43-8, 70-16-6 1130
8 pyruvate Not Applicable
9 Thiamin Not Applicable
10 Vitamins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 18-months Safety Follow-up Study of AADvac1, an Active Tau Vaccine for Alzheimer's Disease Completed NCT02031198 Phase 1 AADvac1
2 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
3 Behavioral Interventions to Prevent or Delay Dementia Completed NCT02265757 Not Applicable
4 Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder Recruiting NCT03095170 Not Applicable
5 An Examination of the Use of Electrophysiological Brain Monitoring to Direct the Treatment of Mild Cognitive Impairment Not yet recruiting NCT03375151 Not Applicable

Search NIH Clinical Center for Amnestic Disorder

Cochrane evidence based reviews: amnesia

Genetic Tests for Amnestic Disorder

Anatomical Context for Amnestic Disorder

MalaCards organs/tissues related to Amnestic Disorder:

42
Brain, Testes, Temporal Lobe, Amygdala, Cortex, Prefrontal Cortex, Thalamus

Publications for Amnestic Disorder

Articles related to Amnestic Disorder:

(show top 50) (show all 1940)
# Title Authors Year
1
Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. ( 30863075 )
2019
2
Burden of Care Implications and Association of Intracranial Hypertension With Extremely Severe Post-traumatic Amnesia After Traumatic Brain Injury: A 5-Year Retrospective Longitudinal Study. ( 30761071 )
2019
3
Addressing post-traumatic amnesia - recommendations for improving patient lives after brain injury. ( 30768563 )
2019
4
Transient epileptic amnesia accompanied by prodromal symptoms of dementia with Lewy bodies: the second case report in the literature. ( 30773739 )
2019
5
NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia. ( 30686545 )
2019
6
Risk of intracranial complications in minor head injury: the role of loss of consciousness and posttraumatic amnesia in a multicenter observational study. ( 30860435 )
2019
7
Childhood amnesia and post-traumatic stress disorder: Attachment vs default mode and executive function. ( 30681005 )
2019
8
Enhanced cortisol secretion in acute transient global amnesia. ( 30193207 )
2019
9
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. ( 30305003 )
2019
10
Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report. ( 30678717 )
2019
11
Myocardial injury in Transient Global Amnesia: a case-control study. ( 30706590 )
2019
12
Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery. ( 30709618 )
2019
13
Transient global amnesia: an intriguing yet benign disturbance. ( 30758435 )
2019
14
Transient global amnesia: clinical features and prognostic factors suggesting recurrence. ( 30758436 )
2019
15
Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation. ( 30804883 )
2019
16
Transient Global Amnesia as the Sole Presentation of an Acute Stroke in the Left Cingulate Gyrus. ( 30915247 )
2019
17
Infantile Amnesia Is Related to Developmental Immaturity of the Maintenance Mechanisms for Long-Term Potentiation. ( 29804230 )
2019
18
Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia. ( 29861041 )
2019
19
Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress. ( 30406376 )
2019
20
Alcohol-Induced Amnesia and Personalized Drinking Feedback: Blackouts Predict Intervention Response. ( 30661564 )
2019
21
Gesture height reflects common ground status even in patients with amnesia. ( 30677621 )
2019
22
Hippocampal contributions to value-based learning: Converging evidence from fMRI and amnesia. ( 30767129 )
2019
23
Isorhamnetin Enhanced Cortico-Hippocampal Learning and Memory Capability in Mice with Scopolamine-Induced Amnesia: Role of Antioxidant Defense, Cholinergic and BDNF Signaling. ( 30772273 )
2019
24
Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. ( 30804787 )
2019
25
Feigned Amnesia as a Defense Reaction. ( 30806681 )
2019
26
Effects of Korsakoff Amnesia on performance and symptom validity testing. ( 30848959 )
2019
27
Saccadic selection does not eliminate attribute amnesia. ( 30883172 )
2019
28
Little evidence for fast mapping in adults with developmental amnesia. ( 30894071 )
2019
29
Capturing real-life forgetting in transient epileptic amnesia via an incidental memory test. ( 29329640 )
2019
30
Effects of 5-HT5A receptor blockade on amnesia or forgetting. ( 29330003 )
2019
31
Dural Arteriovenous Fistula Causing Recurrent Transient Global Amnesia. ( 30245773 )
2018
32
Economic Evaluation of Activities of Daily Living Retraining During Posttraumatic Amnesia for Inpatient Rehabilitation Following Severe Traumatic Brain Injury. ( 30273549 )
2018
33
Restructuring Blank Spaces: The Role of Cognitive-Behavioral Interventions for Two Patients With Post-traumatic Amnesia After Severe Traumatic Brain Injury. ( 30137456 )
2018
34
The value of the identification of predisposing factors for post-traumatic amnesia in management of mild traumatic brain injury. ( 29400569 )
2018
35
Progressively analogous evidence of covert face recognition from functional magnetic resonance imaging and skin conductance responses studies involving a patient with dissociative amnesia. ( 30044019 )
2018
36
State-Dependent Memory: Neurobiological Advances and Prospects for Translation to Dissociative Amnesia. ( 30429781 )
2018
37
A Case of Posterior Reversible Encephalopathy Syndrome with Similar Symptoms as Transient Global Amnesia. ( 30906408 )
2018
38
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient. ( 30530409 )
2018
39
Woman With Headache and Amnesia. ( 30342742 )
2018
40
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. ( 30443620 )
2018
41
Retrograde amnesia after intravenous sedation and general anaesthesia in a dental hospital. ( 30029983 )
2018
42
Postictal pure retrograde amnesia: Response. ( 30442449 )
2018
43
Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia. ( 30460616 )
2018
44
Transient global amnesia: Minor inconvenience or early warning sign? ( 30069134 )
2018
45
Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event. ( 30094523 )
2018
46
Clinics in diagnostic imaging (188). Transient global amnesia (TGA). ( 30109353 )
2018
47
Some thoughts about concomitant transient global amnesia and takotsubo syndrome. ( 30151690 )
2018
48
Medical Procedure-Related Transient Global Amnesia. ( 30205365 )
2018
49
Risk factors of transient global amnesia: Three case reports. ( 30313071 )
2018
50
Vertebral artery loop in a case of recurrent transient global amnesia. ( 30504067 )
2018

Variations for Amnestic Disorder

Expression for Amnestic Disorder

Search GEO for disease gene expression data for Amnestic Disorder.

Pathways for Amnestic Disorder

Pathways related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 CNR1 GABRR3 HTR1A HTR7 OPRD1 OPRK1
2 12.29 CNR1 CREB1 HTR1A OPRM1
3 11.87 BDNF CNR1 CREB1
4 11.77 CNR1 HTR1A TSPO
5
Show member pathways
11.72 BDNF CREB1 PDYN
6 11.67 HTR1A HTR3A HTR7
7 11.23 BDNF CREB1 OPRK1
8 11.23 BDNF CHAT CREB1 HTR1A HTR3A
9 11 ACHE CHAT
10 10.98 BDNF CREB1
11
Show member pathways
10.87 ACHE CHAT
12 10.79 CREB1 HTR7
13 10.78 HTR1A HTR3A HTR7
14 10.55 BDNF CREB1
15 10.45 ACHE CHAT
16 10.17 ACHE CHAT

GO Terms for Amnestic Disorder

Cellular components related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 CNR1 GABRR3 HTR1A HTR3A HTR7 OPRD1
2 synapse GO:0045202 9.83 ACHE GABRR3 HTR3A LGI1 OPRK1
3 dendrite GO:0030425 9.63 BDNF HTR1A HTR7 OPRK1 OPRM1 PDYN
4 axon terminus GO:0043679 9.58 OPRD1 OPRK1 PDYN
5 integral component of postsynaptic membrane GO:0099055 9.54 HTR3A OPRK1 OPRM1
6 synaptic cleft GO:0043083 9.46 ACHE LGI1
7 axon GO:0030424 9.43 BDNF CNR1 CREB1 EIF4G2 HTR3A OPRM1
8 spine apparatus GO:0097444 9.32 OPRD1 OPRM1
9 integral component of presynaptic membrane GO:0099056 9.02 CNR1 HTR3A OPRD1 OPRK1 OPRM1

Biological processes related to Amnestic Disorder according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 CNR1 CREB1 GABRR3 HTR1A HTR3A HTR7
2 cell proliferation GO:0008283 9.92 ACHE HTR1A LGI1 TSPO
3 memory GO:0007613 9.76 BDNF CNR1 CREB1
4 response to ethanol GO:0045471 9.76 CNR1 HTR3A OPRK1 OPRM1
5 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.73 OPRD1 OPRK1 OPRM1
6 cellular response to growth factor stimulus GO:0071363 9.72 CREB1 HTR3A OPRD1
7 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.71 OPRD1 OPRK1 OPRM1
8 sensory perception of pain GO:0019233 9.7 CNR1 OPRK1 OPRM1
9 regulation of sensory perception of pain GO:0051930 9.67 OPRD1 OPRK1 OPRM1
10 neuropeptide signaling pathway GO:0007218 9.67 OPRD1 OPRK1 OPRM1 PDYN
11 response to morphine GO:0043278 9.65 CNR1 OPRK1 OPRM1
12 phosphatidylcholine biosynthetic process GO:0006656 9.63 ACHE CHAT
13 cellular response to zinc ion GO:0071294 9.62 CREB1 TSPO
14 vasoconstriction GO:0042310 9.61 HTR1A HTR7
15 estrous cycle GO:0044849 9.61 OPRK1 OPRM1
16 neurotransmitter biosynthetic process GO:0042136 9.6 ACHE CHAT
17 sensory perception GO:0007600 9.59 OPRK1 OPRM1
18 behavior GO:0007610 9.58 HTR1A OPRK1
19 eating behavior GO:0042755 9.58 OPRD1 OPRK1 OPRM1
20 serotonin receptor signaling pathway GO:0007210 9.57 HTR1A HTR3A
21 response to cocaine GO:0042220 9.46 CNR1 HTR3A OPRK1 OPRM1
22 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.43 OPRK1 OPRM1
23 opioid receptor signaling pathway GO:0038003 9.43 OPRD1 OPRK1 OPRM1
24 chemical synaptic transmission GO:0007268 9.43 GABRR3 HTR1A HTR3A HTR7 OPRK1 PDYN
25 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.02 CNR1 HTR1A HTR7 OPRD1 OPRM1
26 G protein-coupled receptor signaling pathway GO:0007186 10.05 CNR1 HTR1A HTR7 OPRD1 OPRK1 OPRM1

Molecular functions related to Amnestic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.63 CNR1 HTR1A HTR7 OPRD1 OPRK1 OPRM1
2 serotonin binding GO:0051378 9.32 HTR1A HTR3A
3 receptor serine/threonine kinase binding GO:0033612 9.26 OPRD1 OPRK1
4 neuropeptide binding GO:0042923 9.13 OPRD1 OPRK1 OPRM1
5 opioid receptor activity GO:0004985 8.8 OPRD1 OPRK1 OPRM1

Sources for Amnestic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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