MCID: AMN009
MIFTS: 32

Amniotic Band Syndrome

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Amniotic Band Syndrome

MalaCards integrated aliases for Amniotic Band Syndrome:

Name: Amniotic Band Syndrome 53 73
Constricting Bands, Congenital 73
Congenital Constricting Bands 53
Amniotic Bands Sequence 53
Familial Amniotic Bands 53
Streeter Anomaly 53

Classifications:



Summaries for Amniotic Band Syndrome

NIH Rare Diseases : 53 Amniotic band syndrome refers to a condition in which bands develop from the inner lining of the amnion. The amnion is the sac that surrounds the baby in the womb. As the baby develops in the womb, the bands may attach to and affect the development of different areas of the body. This may result in constriction of the affected area or even amputation. The signs and symptoms vary greatly depending on the area(s) of the body involved and may include: shortened or absent digits (fingers and/or toes) or limbs (arms and/or legs), an opening in the abdomen through which various abdominal organs can protrude (abdominal wall defects), protrusion of a portion of the brain and its surrounding membranes through a skull defect (encephalocele), and cleft lip and/or palate. In most instances, the cause of amniotic bands remains unknown. Researchers have suggested two main theories to explain the development: the extrinsic theory and the intrinsic theory. The extrinsic theory states that amniotic band syndrome occurs due to factors found outside of the developing baby (externally); the intrinsic theory states that amniotic band syndrome occurs due to factors found within the baby (internally). Treatment differs depending on the severity of the condition and the areas of the body affected and may include surgery, physical therapy, and occupational therapy.

MalaCards based summary : Amniotic Band Syndrome, also known as constricting bands, congenital, is related to constricting bands, congenital and hypoglossia-hypodactylia. The drugs Glucosamine and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and spinal cord, and related phenotypes are lymphedema and split hand

Related Diseases for Amniotic Band Syndrome

Diseases related to Amniotic Band Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 constricting bands, congenital 11.4
2 hypoglossia-hypodactylia 11.0
3 anencephaly 10.0
4 pseudoarthrosis 9.9
5 meningocele 9.9
6 epidermolysis bullosa 9.9
7 cleft lip 9.9
8 prune belly syndrome 9.7
9 aplasia cutis congenita, nonsyndromic 9.7
10 cleft palate, isolated 9.7
11 strabismus 9.7
12 nuchal bleb, familial 9.7
13 pierre robin syndrome 9.7
14 twin-to-twin transfusion syndrome 9.7
15 granuloma annulare 9.7
16 lymphedema 9.7
17 periventricular nodular heterotopia 9.7
18 orofacial cleft 9.7
19 clubfoot 9.7
20 cystic lymphangioma 9.7
21 teratoma 9.7
22 herpes simplex 9.7
23 chorioretinitis 9.7
24 acalvaria 9.7
25 aplasia cutis congenita 9.7
26 dominant dystrophic epidermolysis bullosa 9.7
27 limb-body wall complex 9.7
28 isolated pierre robin sequence 9.7
29 cleft lip/palate 9.7

Graphical network of the top 20 diseases related to Amniotic Band Syndrome:



Diseases related to Amniotic Band Syndrome

Symptoms & Phenotypes for Amniotic Band Syndrome

Human phenotypes related to Amniotic Band Syndrome:

32 (show all 10)
# Description HPO Frequency HPO Source Accession
1 lymphedema 32 frequent (33%) HP:0001004
2 split hand 32 hallmark (90%) HP:0001171
3 oligohydramnios 32 frequent (33%) HP:0001562
4 talipes 32 hallmark (90%) HP:0001883
5 pulmonary hypoplasia 32 frequent (33%) HP:0002089
6 scoliosis 32 frequent (33%) HP:0002650
7 mitten deformity 32 hallmark (90%) HP:0004057
8 finger syndactyly 32 hallmark (90%) HP:0006101
9 aplasia/hypoplasia of the radius 32 frequent (33%) HP:0006501
10 amniotic constriction ring 32 hallmark (90%) HP:0009775

Drugs & Therapeutics for Amniotic Band Syndrome

Drugs for Amniotic Band Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
2 Fibrinolytic Agents Phase 4
3 Glucuronyl glucosamine glycan sulfate Phase 4
4 Hypoglycemic Agents Phase 4
5 Hypolipidemic Agents Phase 4
6 Anticoagulants Phase 4
7 Lipid Regulating Agents Phase 4
8 Antimetabolites Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4

Search NIH Clinical Center for Amniotic Band Syndrome

Genetic Tests for Amniotic Band Syndrome

Anatomical Context for Amniotic Band Syndrome

MalaCards organs/tissues related to Amniotic Band Syndrome:

41
Brain, Skin, Spinal Cord, Cervix

Publications for Amniotic Band Syndrome

Articles related to Amniotic Band Syndrome:

(show top 50) (show all 156)
# Title Authors Year
1
Amniotic Band Syndrome: A Multidisciplinary Care Approach to the Treatment of a Rare Case. ( 29624436 )
2018
2
The Impact of Microsurgery on Congenital Hand Anomalies Associated with Amniotic Band Syndrome. ( 29876159 )
2018
3
Amniotic Band Syndrome: A Review of 2 Cases. ( 29634607 )
2018
4
Retraction Notice to: Amniotic Band Syndrome with Pseudoarthrosis of Tibia and Fibula: A Case Report [J Foot Ankle Surg. 56 (2017) 1121-1124]. ( 29478484 )
2018
5
Amniotic band syndrome with pseudoarthrosis of tibia and fibula: A case report. ( 28737311 )
2017
6
Aplasia cutis congenita and amniotic band syndrome: an uncommon association. ( 28143861 )
2017
7
Management of the Amniotic Band Syndrome with Cleft Palate: Literature Review and Report of a Case. ( 28246561 )
2017
8
Tessier number 4 bilateral craniofacial cleft associated with amniotic band syndrome: 22 years of follow-up. ( 29246756 )
2017
9
Amniotic Band Syndrome With Pseudoarthrosis of Tibia and Fibula: A Case Report. ( 28623060 )
2017
10
Amniotic band syndrome in dichorionic diamniotic twin pregnancy. ( 29904257 )
2017
11
Uterine contractility as a cause of amniotic band syndrome. ( 27048015 )
2016
12
Amniotic Band Syndrome, Perinatal Hospice, and Palliative Care versus Active Management. ( 28025631 )
2016
13
Prenatal diagnosis of amniotic band syndrome. ( 27081225 )
2016
14
Amniotic Band Syndrome - A Dreaded Condition. ( 26894130 )
2016
15
Image Gallery: Amniotic band syndrome. ( 27317293 )
2016
16
Case of dominant dystrophic epidermolysis bullosa with amniotic band syndrome. ( 27130450 )
2016
17
EP01.10: Amniotic band syndrome mimicking isolated anencephaly. ( 27646670 )
2016
18
Role of Ultrasound in Body Stalk Anomaly and Amniotic Band Syndrome. ( 27699204 )
2016
19
Single stage surgical treatment of amniotic band syndrome a89 Case report. ( 29653043 )
2016
20
Two rare cases of simultaneous Tessier number 3 cleft, contralateral cleft lip, and signs of amniotic band syndrome. ( 27052637 )
2016
21
Oral Rehabilitation for Amniotic Band Syndrome: An Unusual Presentation. ( 26124582 )
2015
22
The Effectiveness of the Ponseti Method for Treating Clubfoot Associated With Amniotic Band Syndrome. ( 25985370 )
2015
23
Novel techniques for the surgical management of abdominopelvic constriction rings in amniotic band syndrome. ( 25626800 )
2015
24
Amniotic band syndrome: a single-institutional experience. ( 25531236 )
2015
25
Amniotic band syndrome with sacral agenesis and umbilical cord entrapment: A case report emphasizing the value of evaluation of umbilical cord. ( 25926929 )
2015
26
Placento-Cranial Adhesions in Amniotic Band Syndrome and the Role of Surgery in Their Management: An Unusual Case Presentation and Systematic Literature Review. ( 26159096 )
2015
27
The amniotic band syndrome in the rat is associated with the activation of transforming growth factor-I^. ( 26055209 )
2015
28
Human tail: a rare feature of amniotic band syndrome? ( 26287557 )
2015
29
An unusual craniofacial cleft: amniotic band syndrome as a possible cause. ( 25661732 )
2015
30
A rare form of congenital amniotic band syndrome: total circular abdominal constriction band. ( 24883282 )
2014
31
Integration of three-dimensional ultrasonography in the prenatal diagnosis of amniotic band syndrome: A case report. ( 24790518 )
2014
32
Fetoscopic approach to amniotic band syndrome. ( 24528986 )
2014
33
Amniotic band syndrome (ABS): can something be done during pregnancy in African poor countries? Three cases and review of the literature. ( 24779260 )
2014
34
The epithelial mesenchymal transition process may contribute to the pathogenesis of amniotic band syndrome. ( 24998668 )
2014
35
Surgical Treatment of Active Amniotic Band Syndrome (ABS) by Z-plasty and Radical Excision of the Overgrown Tissue: A Report of 2 Cases With Progressive Lymphedema Causing Vascular Insufficiency. ( 25264558 )
2014
36
Prenatal diagnosis of amniotic band syndrome - risk factors and ultrasonic signs. ( 24735486 )
2014
37
Circumferential trunk skin defect; a rare presentation of amniotic band syndrome. ( 25223247 )
2014
38
Dystrophic Epidermolysis Bullosa Associated with Amniotic Band Syndrome. ( 24383893 )
2014
39
Amniotic band syndrome. ( 24426485 )
2013
40
Amniotic band syndrome associated with an atypical iris and optic nerve defect. ( 24054035 )
2013
41
Abdominal amniotic band associated with fenestrated syndactyly: a rare amniotic band syndrome presentation. ( 23994229 )
2013
42
Development of a fetal rabbit model to study amniotic band syndrome. ( 22432900 )
2012
43
prenatal diagnosis of amniotic band syndrome in the third trimester of pregnancy using 3D ultrasound. ( 22616039 )
2012
44
Use of the DCI video laryngoscope system in a pediatric patient with amniotic band syndrome and craniofacial abnormalities affecting the airway. ( 22414710 )
2012
45
Ethmocephaly with amniotic band syndrome. ( 23248551 )
2012
46
Epidemiology and risk factors of amniotic band syndrome, or ADAM sequence. ( 23272276 )
2012
47
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. ( 21037281 )
2011
48
Median facial cleft in amniotic band syndrome. ( 21731335 )
2011
49
A case of amniotic band syndrome with cleft lip and palate. ( 23204754 )
2011
50
Congenital vascular anomalies in amniotic band syndrome of the limbs. ( 21376201 )
2011

Variations for Amniotic Band Syndrome

Expression for Amniotic Band Syndrome

Search GEO for disease gene expression data for Amniotic Band Syndrome.

Pathways for Amniotic Band Syndrome

GO Terms for Amniotic Band Syndrome

Sources for Amniotic Band Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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