MCID: AMB007
MIFTS: 20

Amoebic Keratitis

Categories: Eye diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Amoebic Keratitis

MalaCards integrated aliases for Amoebic Keratitis:

Name: Amoebic Keratitis 58

Characteristics:

Orphanet epidemiological data:

58
amoebic keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare eye diseases
Rare infectious diseases


External Ids:

MESH via Orphanet 44 D015823
ICD10 via Orphanet 33 B60.1+ H19.2*
UMLS via Orphanet 72 C0000880
Orphanet 58 ORPHA67043

Summaries for Amoebic Keratitis

MalaCards based summary : Amoebic Keratitis is related to keratitis, hereditary and acanthamoeba keratitis. Affiliated tissues include eye, and related phenotypes are photophobia and ocular pain

Related Diseases for Amoebic Keratitis

Diseases related to Amoebic Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.7
2 acanthamoeba keratitis 10.5
3 yemenite deaf-blind hypopigmentation syndrome 10.0
4 corneal disease 10.0
5 keratopathy 10.0
6 fungal keratitis 10.0

Graphical network of the top 20 diseases related to Amoebic Keratitis:



Diseases related to Amoebic Keratitis

Symptoms & Phenotypes for Amoebic Keratitis

Human phenotypes related to Amoebic Keratitis:

58 31 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000613
2 ocular pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0200026
3 punctate opacification of the cornea 58 31 hallmark (90%) Very frequent (99-80%) HP:0007856
4 cataract 58 31 frequent (33%) Frequent (79-30%) HP:0000518
5 decreased corneal sensation 58 31 frequent (33%) Frequent (79-30%) HP:0012155
6 anterior uveitis 58 31 frequent (33%) Frequent (79-30%) HP:0012122
7 corneal perforation 58 31 frequent (33%) Frequent (79-30%) HP:0100583
8 scleritis 58 31 frequent (33%) Frequent (79-30%) HP:0100532
9 iris atrophy 58 31 frequent (33%) Frequent (79-30%) HP:0001089
10 abnormal posterior eye segment morphology 31 frequent (33%) HP:0004329
11 corneal stromal edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0012040
12 corneal ulceration 58 31 occasional (7.5%) Occasional (29-5%) HP:0012804
13 abnormal anterior chamber morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0000593
14 abnormality of the cornea 58 Very frequent (99-80%)
15 abnormality of corneal epithelium 58 Very frequent (99-80%)
16 abnormality of the posterior segment of the globe 58 Frequent (79-30%)

Drugs & Therapeutics for Amoebic Keratitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Microbiological Diagnosis of Infectious Keratitis to Pathogenic Fastidious Germs Unknown status NCT02819232

Search NIH Clinical Center for Amoebic Keratitis

Genetic Tests for Amoebic Keratitis

Anatomical Context for Amoebic Keratitis

MalaCards organs/tissues related to Amoebic Keratitis:

40
Eye

Publications for Amoebic Keratitis

Articles related to Amoebic Keratitis:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Acanthamoeba mauritaniensis genotype T4D: An environmental isolate displays pathogenic behavior. 61
31669294 2020
2
Acanthamoeba castellanii phosphate transporter (AcPHS) is important to maintain inorganic phosphate influx and is related to trophozoite metabolic processes. 61
31965457 2020
3
Molecular detection of free-living amoebae from Namhangang (southern Han River) in Korea. 61
31942007 2020
4
Acanthamoeba in Southeast Asia - Overview and Challenges. 61
31533401 2019
5
Evaluation of in vitro effect of selected contact lens solutions conjugated with nanoparticles in terms of preventive approach to public health risk generated by Acanthamoeba strains. 61
30922053 2019
6
Evaluation of the sensitivity to chlorhexidine, voriconazole and itraconazole of T4 genotype Acanthamoeba isolated from Mexico. 61
30648558 2019
7
Isolation and molecular identification of Acanthamoeba spp. from hot springs in Mazandaran province, northern Iran. 61
30285961 2018
8
[Corneal collagen cross-linking to treat infectious keratitis]. 61
29903589 2018
9
A comparative study of risk factors for corneal infection in diabetic and non-diabetic patients. 61
29375989 2018
10
Comparison of chlorhexidine disinfectant in vitro effect on environmental and ocular Acanthamoeba strains, the amoebic agents of human keratitis − an emerging sight-threatening corneal disease in Poland 61
30316219 2018
11
Chemical composition and anti-Acanthamoeba activity of Melaleuca styphelioides essential oil. 61
29103900 2017
12
Ammoides pusilla (Apiaceae) essential oil: Activity against Acanthamoeba castellanii Neff. 61
29102680 2017
13
Acanthamoebicidal activity of periglaucine A and betulinic acid from Pericampylus glaucus (Lam.) Merr. in vitro. 61
28916456 2017
14
In vitro evaluation of antimicrobial agents on Acanthamoeba sp. and evidence of a natural resilience to amphotericin B. 61
28918001 2017
15
Isolation and molecular characterization of Acanthamoeba from patients with keratitis in Spain. 61
28756938 2017
16
Free-Living Amoebae Keratitis. 61
28486311 2017
17
Development and validation of a real-time PCR assay for the detection of clinical acanthamoebae. 61
28754142 2017
18
THE USE OF EXTRACTS FROM PASSIFLORA SPP. IN HELPING THE TREATMENT OF ACANTHAMOEBIASIS. 61
29513962 2017
19
Azithromycin and Doxycycline Attenuation of Acanthamoeba Virulence in a Human Corneal Tissue Model. 61
27578848 2017
20
Free-living amoebae isolated in the Central African Republic: epidemiological and molecular aspects. 61
28451034 2017
21
In vivo confocal microscopy and in vitro culture techniques as tools for evaluation of severe Acanthamoeba keratitis incidents 61
29420872 2017
22
Identification of Acanthamoeba Genotypes in Pools and Stagnant Water in Ponds in Sistan Region in Southeast Iran. 61
27905281 2016
23
Isolation and Genotyping of Acanthamoeba spp. as Neglected Parasites in North of Iran. 61
27658596 2016
24
Isolation and genotyping of Acanthamoeba strains (T4, T9, and T11) from amoebic keratitis patients in Iran. 61
27102637 2016
25
Cross-linking for microbial keratitis. 61
27093100 2016
26
Genotyping of Acanthamoeba spp. and characterization of the prevalent T4 type along with T10 and unassigned genotypes from amoebic keratitis patients in India. 61
26887324 2016
27
Genotypic, physiological, and biochemical characterization of potentially pathogenic Acanthamoeba isolated from the environment in Cairo, Egypt. 61
26841771 2016
28
Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. 61
26446087 2016
29
Acanthamoeba genotypes T3 and T4 as causative agents of amoebic keratitis in Mexico. 61
26581373 2016
30
Characterisation and expression analysis of trophozoite and cyst proteins of Acanthamoeba spp. isolated from Acanthamoeba keratitis (AK) patient. 61
27030419 2016
31
Pathogenic Free-Living Amoebae Isolated From Contact Lenses of Keratitis Patients. 61
26811719 2015
32
Reevaluation of an Acanthamoeba Molecular Diagnostic Algorithm following an Atypical Case of Amoebic Keratitis. 61
26202123 2015
33
Acanthamoeba castellanii Proteases are Capable of Degrading Iron-Binding Proteins as a Possible Mechanism of Pathogenicity. 61
25737266 2015
34
Current Status of Acanthamoeba in Iran: A Narrative Review Article. 61
26246812 2015
35
Tigecycline inhibits proliferation of Acanthamoeba castellanii. 61
25563616 2015
36
Identifying differentially expressed genes in trophozoites and cysts of Acanthamoeba T4 genotype: Implications for developing new treatments for Acanthamoeba keratitis. 61
25543551 2015
37
Detection and Molecular Characterization of Potentially Pathogenic Free-living Amoebae from Water Sources in Kish Island, Southern Iran. 61
25922581 2015
38
Abietane diterpenoids from Salvia sclarea transformed roots as growth inhibitors of pathogenic Acanthamoeba spp. 61
25382125 2015
39
Molecular Characterization of Pathogenic Acanthamoeba Isolated from Drinking and Recreational water in East Azerbaijan, Northwest Iran. 61
26157334 2015
40
Genotypic heterogeneity based on 18S-rRNA gene sequences among Acanthamoeba isolates from clinical samples in Italy. 61
24858926 2014
41
Lethal effects of Helianthemum lippii (L.) on Acanthamoeba castellanii cysts in vitro. 61
25031463 2014
42
Silicone hydrogel contact lenses surface promote Acanthamoeba castellanii trophozoites adherence: qualitative and quantitative analysis. 61
24699779 2014
43
Biochemical and cellular mechanisms regulating Acanthamoeba castellanii adherence to host cells. 61
24476561 2014
44
In vitro comparative assessment of different viability assays in Acanthamoeba castellanii and Acanthamoeba polyphaga trophozoites. 61
24026387 2013
45
Characterization of a new pathogenic Acanthamoeba Species, A. byersi n. sp., isolated from a human with fatal amoebic encephalitis. 61
23879685 2013
46
First Report of Hartmannella keratitis in a Cosmetic Soft Contact Lens Wearer in Iran. 61
24454444 2013
47
Loop-mediated isothermal amplification targeting 18S ribosomal DNA for rapid detection of Acanthamoeba. 61
23864737 2013
48
Co-isolation of Vahlkampfia and acanthamoeba in acanthamoeba-like keratitis in a Spanish population. 61
22929156 2013
49
Non-tuberculous mycobacterial keratitis. 61
23211011 2013
50
Chemical composition and amoebicidal activity of Croton pallidulus, Croton ericoides, and Croton isabelli (Euphorbiaceae) essential oils. 61
22526294 2012

Variations for Amoebic Keratitis

Expression for Amoebic Keratitis

Search GEO for disease gene expression data for Amoebic Keratitis.

Pathways for Amoebic Keratitis

GO Terms for Amoebic Keratitis

Sources for Amoebic Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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