MCID: AMX001
MIFTS: 20

Amoxicillin Allergy

Categories: Immune diseases

Aliases & Classifications for Amoxicillin Allergy

MalaCards integrated aliases for Amoxicillin Allergy:

Name: Amoxicillin Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040004
UMLS 73 C0571417

Summaries for Amoxicillin Allergy

Disease Ontology : 12 A beta-lactam allergy that has_allergic_trigger amoxicillin.

MalaCards based summary : Amoxicillin Allergy is related to drug allergy and ischemia. An important gene associated with Amoxicillin Allergy is CD33 (CD33 Molecule), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Amoxicillin and penicillins have been mentioned in the context of this disorder. Affiliated tissues include testes and skin, and related phenotype is Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation.

Related Diseases for Amoxicillin Allergy

Diseases related to Amoxicillin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 drug allergy 10.1
2 ischemia 10.1
3 asthma 9.9
4 myocardial infarction 9.9
5 acute myocardial infarction 9.9
6 colitis 9.9
7 exercise-induced anaphylaxis 9.8 ENPP3 IGHE
8 allergic hypersensitivity disease 9.8 ENPP3 IGHE

Graphical network of the top 20 diseases related to Amoxicillin Allergy:



Diseases related to Amoxicillin Allergy

Symptoms & Phenotypes for Amoxicillin Allergy

GenomeRNAi Phenotypes related to Amoxicillin Allergy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.62 CD33 CD63

Drugs & Therapeutics for Amoxicillin Allergy

Drugs for Amoxicillin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
2 penicillins Not Applicable
3 Anti-Bacterial Agents Not Applicable
4 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) Completed NCT03607734 Not Applicable Amoxicillin

Search NIH Clinical Center for Amoxicillin Allergy

Genetic Tests for Amoxicillin Allergy

Anatomical Context for Amoxicillin Allergy

MalaCards organs/tissues related to Amoxicillin Allergy:

41
Testes, Skin

Publications for Amoxicillin Allergy

Articles related to Amoxicillin Allergy:

(show all 13)
# Title Authors Year
1
Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children. ( 29226807 )
2018
2
Efficacy and Safety of 5-Day Challenge for the Evaluation of Nonsevere Amoxicillin Allergy in Children. ( 29425903 )
2018
3
Importance of Specific IgE/Total IgE Ratio in Disambiguating Amoxicillin Allergy Diagnosis in a Real-Life Setting. ( 29920499 )
2018
4
Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy. ( 28112529 )
2017
5
Provocation Challenges to Evaluate Amoxicillin Allergy in Children. ( 27043299 )
2016
6
Amoxicillin allergy in children: five-day drug provocation test in the diagnosis of nonimmediate reactions. ( 25609343 )
2015
7
Anaphylaxis during skin prick testing for amoxicillin allergy. ( 25017542 )
2014
8
Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy. ( 18331364 )
2008
9
Acute myocardial infarction following amoxicillin allergy: coronary angiography and intravascular ultrasound findings. ( 17982978 )
2007
10
Acute coronary syndrome due to amoxicillin allergy. ( 15005775 )
2004
11
Acute ischaemic colitis due to hypotension and amoxicillin allergy. ( 15138324 )
2004
12
Myocardial ischemia due to severe amoxicillin allergy. ( 15301308 )
2004
13
[Exploration of 112 children suspected of amoxicillin allergy. Indications and efficacy of oral provocation test]. ( 9759183 )
1998

Variations for Amoxicillin Allergy

Expression for Amoxicillin Allergy

Search GEO for disease gene expression data for Amoxicillin Allergy.

Pathways for Amoxicillin Allergy

Pathways related to Amoxicillin Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.14 CD63 ENPP3

GO Terms for Amoxicillin Allergy

Cellular components related to Amoxicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.46 CD33 CD63 ENPP3 IGHE
2 plasma membrane GO:0005886 9.26 CD33 CD63 ENPP3 IGHE
3 external side of plasma membrane GO:0009897 8.8 CD33 ENPP3 IGHE

Biological processes related to Amoxicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.96 ENPP3 IGHE
2 neutrophil degranulation GO:0043312 8.62 CD33 CD63

Sources for Amoxicillin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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