MCID: AMP007
MIFTS: 36

Amphetamine Abuse

Categories: Mental diseases

Aliases & Classifications for Amphetamine Abuse

MalaCards integrated aliases for Amphetamine Abuse:

Name: Amphetamine Abuse 12 55 15

Classifications:



External Ids:

Disease Ontology 12 DOID:670
ICD9CM 35 305.7
UMLS 73 C0154536

Summaries for Amphetamine Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of amphetamines despite negative consequences.

MalaCards based summary : Amphetamine Abuse is related to atypical depressive disorder and alcohol-induced mental disorder. An important gene associated with Amphetamine Abuse is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Circadian entrainment and Phospholipase D signaling pathway. The drugs Dopamine and Amphetamine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and cellular

Related Diseases for Amphetamine Abuse

Diseases related to Amphetamine Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 atypical depressive disorder 10.5 HTR7 MAOB
2 alcohol-induced mental disorder 10.4 NPS SLC6A3
3 specific developmental disorder 10.4 HTR7 SLC6A2 SLC6A3
4 antisocial personality disorder 10.4 HTR1B MAOB SLC6A3
5 personality disorder 10.3 HTR1B MAOB SLC6A3
6 brunner syndrome 10.3 HTR1B HTR7 MAOB
7 restless legs syndrome 10.1 MAOB NTS SLC6A3
8 major depressive disorder 10.1 GRM5 HTR1B SLC6A2 SLC6A3
9 mood disorder 10.1 HTR1B MAOB SLC6A2
10 myocardial infarction 10.0
11 acute myocardial infarction 10.0
12 central nervous system disease 10.0 KANTR MAOB SLC6A3
13 oculogyric crisis 10.0 KANTR MAOB
14 alcohol dependence 10.0 HTR1B HTR7 MAOB SLC6A3
15 cerebritis 9.9
16 alcoholic psychosis 9.9 NPS SLC6A3
17 postencephalitic parkinson disease 9.9 KANTR MAOB
18 nervous system disease 9.8 KANTR MAOB SLC6A3
19 transsexuality 9.8
20 holoprosencephaly 9.8
21 thrombosis 9.8
22 transsexualism 9.8
23 arteriovenous malformation 9.8
24 superior mesenteric artery syndrome 9.8
25 movement disease 9.8
26 aneurysm 9.8
27 attention deficit-hyperactivity disorder 9.7 GRM5 HTR1B MAOB SLC6A2 SLC6A3
28 synucleinopathy 9.4 GRM5 MAOB PVALB SLC6A3
29 parkinson disease, late-onset 9.3 GRM5 MAOB MAPK14 NTS SLC6A3
30 migraine with or without aura 1 9.1 HTR1B HTR7 KANTR MAOB NPS SLC6A3
31 disease of mental health 8.3 GRM2 GRM5 HTR7 NPS PVALB SLC6A2
32 schizophrenia 7.6 GRM2 GRM5 HTR1B HTR7 MAOB NTS

Graphical network of the top 20 diseases related to Amphetamine Abuse:



Diseases related to Amphetamine Abuse

Symptoms & Phenotypes for Amphetamine Abuse

MGI Mouse Phenotypes related to Amphetamine Abuse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ARC GRM2 GRM5 HTR1B HTR7 MAOB
2 cellular MP:0005384 9.85 GRM2 HTR1B ITK MAOB MAP3K5 MAPK14
3 homeostasis/metabolism MP:0005376 9.73 GRM2 HTR7 IVD MAOB MAP3K5 MAPK14
4 nervous system MP:0003631 9.4 NTS PRKCB PVALB SLC22A3 SLC6A2 SLC6A3

Drugs & Therapeutics for Amphetamine Abuse

Drugs for Amphetamine Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
2
Amphetamine Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 300-62-9 5826 3007
3
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5 Adrenergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
6 Central Nervous System Stimulants Phase 4,Phase 2,Phase 1,Not Applicable
7 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
8 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
9 Dopamine Agents Phase 4,Phase 2,Phase 1,Not Applicable
10 Dopamine Uptake Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
12 Autonomic Agents Phase 4,Phase 2,Phase 1,Not Applicable
13 Quetiapine Fumarate Phase 4 111974-72-2
14 Central Nervous System Depressants Phase 4
15 Serotonin Agents Phase 4,Not Applicable
16 Serotonin Antagonists Phase 4
17 Anesthetics Phase 4
18 Anesthetics, Local Phase 4
19 Tranquilizing Agents Phase 4
20 Vasoconstrictor Agents Phase 4
21 Dopamine Antagonists Phase 4
22 Antipsychotic Agents Phase 4
23 Psychotropic Drugs Phase 4
24
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
25
Dextroamphetamine Approved, Illicit Phase 2,Phase 1 51-64-9 5826
26
Diethylpropion Approved, Illicit Phase 1, Phase 2 90-84-6, 134-80-5 7029
27 Anti-Obesity Agents Phase 1, Phase 2
28 Lisdexamfetamine Dimesylate Phase 2,Phase 1
29 Appetite Depressants Phase 1, Phase 2
30
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
31
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
32
Sage Approved, Nutraceutical Not Applicable
33
Choline Approved, Nutraceutical Not Applicable 62-49-7 305
34 Chlorpheniramine, phenylpropanolamine drug combination Not Applicable
35 Cytidine Diphosphate Choline Not Applicable
36 N-Methyl-3,4-methylenedioxyamphetamine Not Applicable
37 Nootropic Agents Not Applicable
38 Antidepressive Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia Completed NCT00208143 Phase 4 Quetiapine;Risperidone
2 Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories Completed NCT00247572 Phase 2 NRP104
3 Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse Completed NCT00248092 Phase 1, Phase 2 NRP104
4 Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence Unknown status NCT01273701 Not Applicable
5 A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence Completed NCT00377299 Not Applicable Citicoline;Placebo
6 Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging Completed NCT01296802 Not Applicable dexfenfluramine

Search NIH Clinical Center for Amphetamine Abuse

Genetic Tests for Amphetamine Abuse

Anatomical Context for Amphetamine Abuse

Publications for Amphetamine Abuse

Articles related to Amphetamine Abuse:

(show top 50) (show all 80)
# Title Authors Year
1
Cardiovascular Complications of Acute Amphetamine Abuse: Cross-sectional study. ( 28417026 )
2017
2
Facial movement disorder and dopamine imaging in a patient with amphetamine abuse. ( 27502592 )
2016
3
Amphetamine Abuse Related Acute Myocardial Infarction. ( 26998366 )
2016
4
Tamoxifen and amphetamine abuse: Are there therapeutic possibilities? ( 27585851 )
2016
5
Superior Mesenteric Artery Syndrome Associated with Rapid Weight Loss Attributed to Amphetamine Abuse. ( 26351593 )
2015
6
Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: a population-based assessment. ( 25479916 )
2015
7
Amphetamine abuse as a rare cause of recurrent LVAD pump thrombosis. ( 25545600 )
2015
8
Factors associated with buprenorphine compared to amphetamine abuse among clients seeking treatment in Finland. ( 24560129 )
2014
9
Extreme Procalcitonin Elevation without Proven Bacterial Infection Related to Amphetamine Abuse. ( 24826347 )
2014
10
Efficacy of psychostimulant drugs for amphetamine abuse or dependence. ( 23996457 )
2013
11
Androgenic anabolic steroid, cocaine and amphetamine abuse and adverse cardiovascular effects. ( 24719633 )
2013
12
Amphetamine abuse in Sweden: subject demographics, changes in blood concentrations over time, and the types of coingested substances. ( 23422398 )
2013
13
Amphetamine abuse in emergency department patients undergoing psychiatric evaluation. ( 22538120 )
2012
14
Acute demyelination in a person with amphetamine abuse. ( 22937385 )
2011
15
Rhabdomyolysis accompanied by spontaneous spinal subdural and subarachnoid hematoma related to amphetamine abuse. ( 20081506 )
2010
16
Modafinil treatment of amphetamine abuse in adult ADHD. ( 18562425 )
2009
17
Hospitalizations with amphetamine abuse among pregnant women. ( 18238971 )
2008
18
The prevalence of methamphetamine and amphetamine abuse in North America: a review of the indicators, 1992-2007. ( 18368603 )
2008
19
Amphetamine abuse in pregnancy: the impact on obstetric outcome. ( 17285340 )
2007
20
Contrast enhanced computer tomography of two cases of bilateral acute cortical necrosis, one of which related to amphetamine abuse. ( 16133628 )
2005
21
Coronary artery rupture associated with amphetamine abuse. ( 15316310 )
2004
22
Amphetamine abuse in pregnancy: anesthetic implications. ( 12872434 )
2003
23
Rapidly growing internal carotid artery aneurysm after amphetamine abuse: case report. ( 12604995 )
2003
24
Asia grapples with spreading amphetamine abuse. ( 12788585 )
2003
25
Massive intracerebral hematoma and extradural hematoma in amphetamine abuse. ( 11781916 )
2002
26
Altered response to intravenous thiopental and succinylcholine in acute amphetamine abuse. ( 12027859 )
2002
27
Vertebral artery dissection with amphetamine abuse. ( 17903796 )
2001
28
Dexamphetamine substitution in the treatment of amphetamine abuse: an initial investigation. ( 10723851 )
2000
29
Differentiation of clobenzorex use from amphetamine abuse using the metabolite 4-hydroxyclobenzorex. ( 11043667 )
2000
30
Amphetamine abuse during pregnancy: environmental factors and outcome after 14-15 years. ( 10954143 )
2000
31
Amphetamine abuse and intracranial haemorrhage. ( 11089483 )
2000
32
Intracerebral haemorrhage in a young adult: consider amphetamine abuse. ( 8731653 )
1996
33
Consumption coagulopathy after amphetamine abuse in pregnancy. ( 7660777 )
1995
34
Intracerebral haemorrhage due to amphetamine abuse: report of two cases with underlying arteriovenous malformations. ( 7786436 )
1995
35
Acute myocardial infarction resulting from amphetamine abuse: a spasm-thrombus interplay? ( 7985607 )
1994
36
Holoprosencephaly and trisomy 13 in a fetus with maternal early gestational amphetamine abuse--a case report. ( 8207770 )
1993
37
Acute myocardial infarction caused by intravenous amphetamine abuse. ( 2390398 )
1990
38
Intraventricular hemorrhage following amphetamine abuse. ( 2381547 )
1990
39
Update on amphetamine abuse. ( 18750614 )
1989
40
Intracranial haemorrhage caused by amphetamine abuse. ( 2614776 )
1989
41
Bladder outflow obstruction secondary to intravenous amphetamine abuse. ( 2804574 )
1989
42
Intracerebral hemorrhage and angiographic beading following amphetamine abuse. ( 3356528 )
1988
43
Psychotic manifestations in amphetamine abuse--experimental study on the mechanism of psychotic recurrence. ( 3797582 )
1986
44
Intravenous amphetamine abuse, primary cerebral mucormycosis, and acquired immunodeficiency. ( 3998699 )
1985
45
Nails as useful materials for detection of methamphetamine or amphetamine abuse. ( 6698458 )
1984
46
Acute cardiomyopathy secondary to intravenous amphetamine abuse. ( 7125413 )
1982
47
Amphetamine abuse and transsexualism. ( 7108506 )
1982
48
Violence: the ugly face of amphetamine abuse. ( 6114085 )
1981
49
Intracranial hemorrhage with amphetamine abuse. ( 7196521 )
1981
50
Amphetamine abuse and obstetrical anesthesia. ( 7191233 )
1980

Variations for Amphetamine Abuse

Expression for Amphetamine Abuse

Search GEO for disease gene expression data for Amphetamine Abuse.

Pathways for Amphetamine Abuse

GO Terms for Amphetamine Abuse

Cellular components related to Amphetamine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.17 GRM2 GRM5 HTR1B HTR7 SLC22A3 SLC6A2

Biological processes related to Amphetamine Abuse according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.81 HTR1B MAOB SLC6A2 SLC6A3
2 response to ethanol GO:0045471 9.71 HTR1B MAOB SLC6A3
3 positive regulation of myoblast differentiation GO:0045663 9.55 MAP3K5 MAPK14
4 vasoconstriction GO:0042310 9.52 HTR1B HTR7
5 G-protein coupled glutamate receptor signaling pathway GO:0007216 9.49 GRM2 GRM5
6 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 9.48 GRM2 GRM5
7 dopamine catabolic process GO:0042420 9.46 MAOB SLC6A3
8 dopamine transport GO:0015872 9.43 SLC22A3 SLC6A3
9 p38MAPK cascade GO:0038066 9.4 MAP3K5 MAPK14
10 chemical synaptic transmission GO:0007268 9.35 GRM2 GRM5 HTR1B HTR7 SLC6A2
11 dopamine uptake involved in synaptic transmission GO:0051583 9.32 SLC6A2 SLC6A3
12 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.26 HTR1B HTR7
13 negative regulation of serotonin secretion GO:0014063 9.16 HTR1B MAOB
14 monoamine transport GO:0015844 8.8 SLC22A3 SLC6A2 SLC6A3
15 signal transduction GO:0007165 10.02 GRM2 GRM5 HTR1B HTR7 ITK MAPK14

Molecular functions related to Amphetamine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate receptor activity GO:0008066 9.37 GRM2 GRM5
2 neurotransmitter:sodium symporter activity GO:0005328 9.32 SLC6A2 SLC6A3
3 serotonin binding GO:0051378 9.26 HTR1B HTR7
4 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A2 SLC6A3
5 dopamine transmembrane transporter activity GO:0005329 8.96 SLC22A3 SLC6A3
6 dopamine:sodium symporter activity GO:0005330 8.62 SLC6A2 SLC6A3

Sources for Amphetamine Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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