MCID: AMP009
MIFTS: 40

Ampulla of Vater Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ampulla of Vater Adenocarcinoma

MalaCards integrated aliases for Ampulla of Vater Adenocarcinoma:

Name: Ampulla of Vater Adenocarcinoma 12 15 17
Adenocarcinoma of Ampulla of Vater 12 74
Ampullary Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3502
NCIt 51 C6650
UMLS 74 C1332243

Summaries for Ampulla of Vater Adenocarcinoma

Disease Ontology : 12 An ampulla of Vater carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Ampulla of Vater Adenocarcinoma, also known as adenocarcinoma of ampulla of vater, is related to pancreas adenocarcinoma and adenocarcinoma, and has symptoms including vomiting, abdominal pain and pruritus. An important gene associated with Ampulla of Vater Adenocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Oxaliplatin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include endothelial, pancreas and small intestine, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Ampulla of Vater Adenocarcinoma

Diseases related to Ampulla of Vater Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 pancreas adenocarcinoma 29.5 BRCA2 CDX2 MUC1 MUC2
2 adenocarcinoma 10.6
3 spindle cell carcinoma 10.4 KRT7 MUC1
4 cavernous hemangioma 10.4 KRT7 MUC1
5 adenosquamous carcinoma 10.4 KRT7 MUC1
6 epithelioid sarcoma 10.4 KRT7 MUC1
7 pericardial mesothelioma 10.4 KRT7 MUC1
8 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
9 mucinous adenofibroma 10.3 CDX2 KRT7
10 primary cutaneous amyloidosis 10.3 KRT17 KRT7
11 anus adenocarcinoma 10.3 CDX2 KRT7
12 solid adenocarcinoma with mucin production 10.3 KRT7 MUC1
13 endosalpingiosis 10.3 KRT7 MUC1
14 hepatoid adenocarcinoma 10.3 CDX2 MUC1
15 epithelial predominant wilms' tumor 10.3 CDX2 KRT7
16 parachordoma 10.3 KRT7 MUC1
17 secretory meningioma 10.3 KRT7 MUC1
18 middle ear adenoma 10.3 KRT7 MUC1
19 nasal cavity cancer 10.3 CDX2 KRT7
20 suppurative cholangitis 10.3 CDX2 MUC2
21 nodular hidradenoma 10.3 KRT7 MUC1
22 intestinal benign neoplasm 10.3 CDX2 MUC2
23 hidradenoma 10.3 KRT7 MUC1
24 clear cell basal cell carcinoma 10.3 KRT17 KRT7
25 gastrointestinal carcinoma 10.3 KRT20 MUC1
26 colorectal cancer 1 10.3 MUC1 MUC2
27 fuchs' endothelial dystrophy 10.3 KRT20 MUC1
28 monophasic synovial sarcoma 10.3 KRT7 MUC1
29 cholecystitis 10.3 MUC1 MUC2
30 nasal cavity adenocarcinoma 10.3 CDX2 KRT7
31 anal canal adenocarcinoma 10.3 CDX2 KRT7
32 adenomyoma 10.3 KRT7 MUC1
33 ovarian brenner tumor 10.3 KRT20 KRT7
34 inverted papilloma 10.3 KRT20 KRT7
35 spiradenoma 10.3 KRT7 MUC1
36 clear cell adenocarcinoma 10.3 KRT20 KRT7
37 large cell acanthoma 10.3 KRT17 KRT7
38 mucinous intrahepatic cholangiocarcinoma 10.3 CDX2 MUC2
39 vaginal benign neoplasm 10.3 CDX2 KRT20
40 vaginal adenoma 10.2 CDX2 KRT20
41 vaginal tubulovillous adenoma 10.2 CDX2 KRT20
42 well-differentiated liposarcoma 10.2 KRT7 MUC1
43 actinic keratosis 10.2 KRT17 KRT20
44 bowen's disease 10.2 KRT17 KRT7
45 sertoli-leydig cell tumor 10.2 KRT7 MUC1
46 tumor of exocrine pancreas 10.2 MUC1 MUC2
47 spindle cell sarcoma 10.2 KRT7 MUC1
48 pancreatic intraductal papillary-mucinous neoplasm 10.2 MUC1 MUC2
49 sclerosing hemangioma 10.2 KRT7 MUC1
50 cystic basal cell carcinoma 10.2 KRT20 KRT7

Graphical network of the top 20 diseases related to Ampulla of Vater Adenocarcinoma:



Diseases related to Ampulla of Vater Adenocarcinoma

Symptoms & Phenotypes for Ampulla of Vater Adenocarcinoma

UMLS symptoms related to Ampulla of Vater Adenocarcinoma:


vomiting, abdominal pain, pruritus, nausea, icterus, malaise

MGI Mouse Phenotypes related to Ampulla of Vater Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 BRCA2 CDX2 CTTN KRT17 KRT7 MUC2
2 digestive/alimentary MP:0005381 9.02 BRCA2 CDX2 KRT17 MUC2 SOX2

Drugs & Therapeutics for Ampulla of Vater Adenocarcinoma

Drugs for Ampulla of Vater Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
4
s 1 (combination) Phase 2
5 Antimetabolites, Antineoplastic Phase 2,Phase 1
6 Immunoglobulin G Phase 2
7 Endothelial Growth Factors Phase 2
8 Angiogenesis Inhibitors Phase 2
9 Immunoglobulins Phase 2
10 Mitogens Phase 2
11 Antibodies Phase 2
12 Immunologic Factors Phase 2,Phase 1
13 Angiogenesis Modulating Agents Phase 2
14 Antibodies, Monoclonal Phase 2
15 Antimetabolites Phase 2,Phase 1
16 Antineoplastic Agents, Immunological Phase 2
17
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
18
Gemcitabine Approved Phase 1 95058-81-4 60750
19 Immunosuppressive Agents Phase 1
20 Anti-Infective Agents Phase 1
21 Antiviral Agents Phase 1
22
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
23 Gastrointestinal Agents Not Applicable
24 pancreatin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of S-1 Oxaliplatin (SOX) for Biliary Tract Cancer (BTC) (Ampullary Adenocarcinoma) Unknown status NCT01180153 Phase 2 S-1 oxaliplatin
2 Bevacizumab, Capecitabine, and Oxaliplatin in Treating Advanced Small Intestinal or Ampulla of Vater Adenocarcinoma Completed NCT01208103 Phase 2 Capecitabine;Oxaliplatin
3 ADH-1, Gemcitabine Hydrochloride and Cisplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic or Biliary Tract Cancer That Cannot Be Removed by Surgery Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
4 Survival and Description of Care for Patients With Degenerate Vaterian Ampulloma Recruiting NCT03800212 treatment for ampullary adenocarcinoma
5 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Ampulla of Vater Adenocarcinoma

Genetic Tests for Ampulla of Vater Adenocarcinoma

Anatomical Context for Ampulla of Vater Adenocarcinoma

MalaCards organs/tissues related to Ampulla of Vater Adenocarcinoma:

42
Endothelial, Pancreas, Small Intestine, Appendix, Liver, Kidney, Thymus

Publications for Ampulla of Vater Adenocarcinoma

Articles related to Ampulla of Vater Adenocarcinoma:

(show all 11)
# Title Authors Year
1
Ampulla of vater adenocarcinoma in a BRCA2 germline mutation carrier. ( 23417715 )
2014
2
Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. ( 25436120 )
2014
3
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma. ( 23030700 )
2013
4
Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review. ( 19444594 )
2009
5
Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. ( 16596179 )
2006
6
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. ( 15725805 )
2005
7
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. ( 14677066 )
2004
8
Skull metastasis from ampulla of Vater adenocarcinoma: case report. ( 15072455 )
2004
9
Composite carcinoid-adenocarcinoma of ampulla of Vater. ( 2227927 )
1990
10
[Adenocarcinoma of ampulla of Vater]. ( 15407174 )
1949
11
Liver abscess due to Friedlander's bacillus (K. pneumoniae) complicating adenocarcinoma of ampulla of Vater. ( 21010667 )
1945

Variations for Ampulla of Vater Adenocarcinoma

Expression for Ampulla of Vater Adenocarcinoma

Search GEO for disease gene expression data for Ampulla of Vater Adenocarcinoma.

Pathways for Ampulla of Vater Adenocarcinoma

Pathways related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT17 KRT20 KRT7
2 11.51 CTTN KRT17 KRT20 KRT7 MUC1
3 10.19 CDX2 SOX2

GO Terms for Ampulla of Vater Adenocarcinoma

Cellular components related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT17 KRT20 KRT7

Biological processes related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT17 KRT20 KRT7
2 somatic stem cell population maintenance GO:0035019 9.37 CDX2 SOX2
3 positive regulation of cell differentiation GO:0045597 9.32 CDX2 SOX2
4 intermediate filament organization GO:0045109 9.16 KRT17 KRT20
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 MUC1 BRCA2
6 cornification GO:0070268 8.8 KRT17 KRT20 KRT7

Sources for Ampulla of Vater Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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