MCID: AMP009
MIFTS: 36

Ampulla of Vater Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ampulla of Vater Adenocarcinoma

MalaCards integrated aliases for Ampulla of Vater Adenocarcinoma:

Name: Ampulla of Vater Adenocarcinoma 12 15 17
Adenocarcinoma of Ampulla of Vater 12 70
Ampullary Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3502
NCIt 50 C6650
UMLS 70 C1332243

Summaries for Ampulla of Vater Adenocarcinoma

Disease Ontology : 12 An ampulla of Vater carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Ampulla of Vater Adenocarcinoma, also known as adenocarcinoma of ampulla of vater, is related to mesothelioma, malignant and adenocarcinoma, and has symptoms including vomiting, abdominal pain and pruritus. An important gene associated with Ampulla of Vater Adenocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are MicroRNAs in cancer and Cytoskeletal Signaling. The drugs Oxaliplatin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast, pancreas and lung.

Related Diseases for Ampulla of Vater Adenocarcinoma

Diseases related to Ampulla of Vater Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 mesothelioma, malignant 30.5 MUC1 KRT7 KRT20
2 adenocarcinoma 30.5 MUC1 KRT7 KRT20 CDX2 BRCA2
3 pancreatic ductal carcinoma 30.5 MUC5AC MUC2 MUC1 KRT7 KRT20
4 intrahepatic cholangiocarcinoma 30.3 MUC5AC MUC1 KRT7 KRT20 CDX2
5 intestinal obstruction 30.3 KRT7 KRT20 CDX2
6 gastrointestinal carcinoma 30.3 MUC1 KRT20 CDX2
7 adenoma 30.2 MUC5AC MUC1 KRT7 KRT20 CDX2
8 cystadenoma 30.2 MUC5AC MUC1 KRT7 KRT20
9 cholangiocarcinoma 30.1 MUC5AC MUC2 MUC1 KRT7 KRT20 CDX2
10 duodenum adenocarcinoma 30.0 MUC5AC MIR196A1 KRT7 CDX2
11 bile duct adenocarcinoma 29.8 MIR196A1 MIR145 KRT7
12 bile duct cancer 29.7 MUC5AC MUC1 MIR145 KRT7 FSCN1 CDX2
13 duodenum cancer 29.6 MUC5AC MUC1 MIR196A1 KRT7 KRT20 CDX2
14 pancreatic ductal adenocarcinoma 29.6 MUC1 MIR222 MIR196A1 MIR145 BRCA2
15 pancreatic cancer 28.1 MUC5AC MUC2 MUC1 MIR222 MIR196A1 MIR145
16 ampulla of vater cancer 27.5 MUC5AC MUC1 MIRLET7G MIR377 MIR30D MIR196A1
17 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
18 anal canal paget's disease 10.4 KRT7 CDX2
19 anal paget's disease 10.4 KRT7 CDX2
20 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
21 scrotum paget's disease 10.4 MUC1 KRT7
22 ureter adenocarcinoma 10.4 KRT7 CDX2
23 colloid carcinoma of the pancreas 10.4 MUC5AC MUC1
24 mucinous adenofibroma 10.4 KRT7 CDX2
25 pancreatic signet ring cell adenocarcinoma 10.4 MUC5AC MUC1
26 intrahepatic biliary papillomatosis 10.4 MUC5AC MUC1
27 adenosquamous colon carcinoma 10.4 KRT7 CDX2
28 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
29 bartholin's gland disease 10.4 KRT7 CDX2
30 chronic ethmoiditis 10.4 MUC5AC MUC1
31 bartholin's gland carcinoma 10.4 KRT7 CDX2
32 bile duct mucinous adenocarcinoma 10.4 MUC5AC MUC1
33 urethral villous adenoma 10.4 KRT7 KRT20
34 ovarian seromucinous carcinoma 10.4 KRT7 CDX2
35 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
36 nephrogenic adenoma 10.4 MUC1 KRT7
37 thymus adenocarcinoma 10.4 KRT20 CDX2
38 bladder benign neoplasm 10.4 KRT7 KRT20
39 nephrogenic adenoma of urinary bladder 10.4 KRT7 KRT20
40 appendiceal neoplasm 10.4 KRT7 CDX2
41 atrophic vulva 10.4 KRT7 KRT20
42 pancreatic serous cystadenocarcinoma 10.4 KRT7 KRT20
43 middle ear adenoma 10.4 MUC1 KRT7
44 ethmoid sinus cancer 10.4 CTTN CDX2
45 apocrine adenocarcinoma 10.4 MUC1 KRT7
46 rectosigmoid junction neoplasm 10.4 KRT7 KRT20
47 transverse colon cancer 10.4 KRT7 KRT20
48 urinary bladder small cell neuroendocrine carcinoma 10.4 KRT7 KRT20
49 vulvar apocrine adenocarcinoma 10.4 KRT7 KRT20
50 syringoma 10.4 MUC1 KRT7

Graphical network of the top 20 diseases related to Ampulla of Vater Adenocarcinoma:



Diseases related to Ampulla of Vater Adenocarcinoma

Symptoms & Phenotypes for Ampulla of Vater Adenocarcinoma

UMLS symptoms related to Ampulla of Vater Adenocarcinoma:


vomiting; abdominal pain; pruritus; nausea; icterus; malaise

Drugs & Therapeutics for Ampulla of Vater Adenocarcinoma

Drugs for Ampulla of Vater Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
2
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4 Antineoplastic Agents, Immunological Phase 2
5 Angiogenesis Inhibitors Phase 2
6 Immunoglobulins Phase 2
7 Mitogens Phase 2
8 Immunoglobulin G Phase 2
9 Immunoglobulins, Intravenous Phase 2
10 Immunologic Factors Phase 2
11 Endothelial Growth Factors Phase 2
12 Antibodies Phase 2
13 Antibodies, Monoclonal Phase 2
14 Antimetabolites Phase 2
15
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
16
Gemcitabine Approved Phase 1 95058-81-4 60750
17 Immunosuppressive Agents Phase 1
18 Antiviral Agents Phase 1
19 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Pilot Study of S-1 Combined With Oxaliplatin for First-line Treatment of Unresectable, Metastatic or Locally Advanced Biliary Tract Cancer or Ampullary Adenocarcinoma Unknown status NCT01180153 Phase 2 S-1 oxaliplatin
2 Phase II Study of Bevacizumab Combined With Capecitabine and Oxaliplatin (CAPOX) in Patients With Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed NCT01208103 Phase 2 Capecitabine;Oxaliplatin
3 A Phase I Study of ADH-1 and Gemcitabine Plus Cisplatin in Patients With Unresectable or Metastatic Pancreatic and Biliary Tract Cancers Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
4 Study of Survival and Description of Care for Patients With Degenerate Vaterian Ampulloma Recruiting NCT03800212 treatment for ampullary adenocarcinoma
5 An International Multi-centre Retrospective Cohort Study Investigating Patterns of Cancer Recurrence Following Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma, Ampullary Adenocarcinoma and Distal Bile Duct Cholangiocarcinoma Recruiting NCT04596865

Search NIH Clinical Center for Ampulla of Vater Adenocarcinoma

Genetic Tests for Ampulla of Vater Adenocarcinoma

Anatomical Context for Ampulla of Vater Adenocarcinoma

MalaCards organs/tissues related to Ampulla of Vater Adenocarcinoma:

40
Breast, Pancreas, Lung, Ovary, Appendix, Thymus, Colon

Publications for Ampulla of Vater Adenocarcinoma

Articles related to Ampulla of Vater Adenocarcinoma:

(show all 33)
# Title Authors PMID Year
1
Clinicopathological Prognostic Factors and Chemotherapeutic Outcome for Two Histopathological Types of Ampulla of Vater Adenocarcinoma. 61
33680964 2021
2
Laparoscopic liver resection after laparoscopic pancreatoduodenectomy for liver metastases of ampulla of Vater adenocarcinoma. 61
33030624 2020
3
Primary malignant pericardial tumour in Lynch syndrome. 61
32143595 2020
4
Challenges in the management of adenocarcinoma of ampulla of Vater in pregnancy: A case report and review of literature. 61
31306902 2019
5
Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater. 61
29736668 2018
6
Sarcomatoid Adenocarcinoma of the Ampulla of Vater. 61
29887717 2018
7
Adenocarcinoma of the ampulla of Vater: what treatment options are available? 61
24906539 2015
8
Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. 61
25436120 2014
9
Adenocarcinoma of the minor duodenal papilla and its precursor lesions: a clinical and pathologic study. 61
24625417 2014
10
Ampulla of vater adenocarcinoma in a BRCA2 germline mutation carrier. 61
23417715 2014
11
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma. 61
23030700 2013
12
Acute respiratory failure as a rare complication of celiac plexus block in a patient with adenocarcinoma of the ampulla of vater. 61
25191416 2012
13
Carcinoid tumors of the extrahepatic biliary tract: report of four cases. 61
21365432 2011
14
Immunohistochemical study of mucin expression in periampullary adenomyoma. 61
19784541 2010
15
Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review. 61
19444594 2009
16
Evaluation of POSSUM for patients undergoing pancreatoduodenectomy. 61
19384458 2009
17
Pancreas-preserving total duodenectomy versus standard pancreatoduodenectomy for patients with familial adenomatous polyposis and polyps in the duodenum. 61
18844249 2008
18
Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors. 61
17468917 2007
19
Management of solid-pseudopapillary neoplasms of the pancreas: a comparison with standard pancreatic neoplasms. 61
17429567 2007
20
Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. 61
17295772 2007
21
Maspin expression in adenocarcinoma of the ampulla of Vater: relation with clinicopathological parameters and apoptosis. 61
17465244 2007
22
Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. 61
16596179 2006
23
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. 61
15725805 2005
24
Endobronchial metastases from extrathoracic malignancies. 61
16475029 2005
25
Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy. 61
15531230 2004
26
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. 61
14677066 2004
27
Skull metastasis from ampulla of Vater adenocarcinoma: case report. 61
15072455 2004
28
Obstructive jaundice resulting from adenocarcinoma of the ampulla of Vater in an 11-year-old boy. 61
9126774 1997
29
Percutaneous transhepatic biliary biopsy using gastrofiberscopic biopsy forceps. 61
1299235 1992
30
Gynecological malignancies, brain tumors, and familial adenomatous polyposis. 61
1649354 1991
31
Composite carcinoid-adenocarcinoma of ampulla of Vater. 61
2227927 1990
32
[Adenocarcinoma of ampulla of Vater]. 61
15407174 1949
33
Liver abscess due to Friedlander's bacillus (K. pneumoniae) complicating adenocarcinoma of ampulla of Vater. 61
21010667 1945

Variations for Ampulla of Vater Adenocarcinoma

Expression for Ampulla of Vater Adenocarcinoma

Search GEO for disease gene expression data for Ampulla of Vater Adenocarcinoma.

Pathways for Ampulla of Vater Adenocarcinoma

GO Terms for Ampulla of Vater Adenocarcinoma

Cellular components related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.13 MUC5AC MUC2 MUC1
2 mucus layer GO:0070701 8.62 MUC5AC MUC2

Biological processes related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.58 MUC5AC MUC2 MUC1
2 cornification GO:0070268 9.54 KRT7 KRT20 KRT17
3 intermediate filament organization GO:0045109 9.43 KRT20 KRT17
4 O-glycan processing GO:0016266 9.33 MUC5AC MUC2 MUC1
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 BRCA2
6 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.26 MIRLET7G MIR222
7 negative regulation of inflammatory response GO:0050728 9.26 MIRLET7G MIR222 MIR187 MIR145
8 gene silencing by miRNA GO:0035195 9.17 MIRLET7G MIR377 MIR30D MIR222 MIR196A1 MIR187

Molecular functions related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIRLET7G MIR222 MIR196A1 MIR187 MIR145

Sources for Ampulla of Vater Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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