MCID: AMP009
MIFTS: 35

Ampulla of Vater Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ampulla of Vater Adenocarcinoma

MalaCards integrated aliases for Ampulla of Vater Adenocarcinoma:

Name: Ampulla of Vater Adenocarcinoma 12 15
Adenocarcinoma of Ampulla of Vater 12 73
Ampullary Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3502
NCIt 50 C6650
UMLS 73 C1332243

Summaries for Ampulla of Vater Adenocarcinoma

Disease Ontology : 12 An ampulla of Vater carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Ampulla of Vater Adenocarcinoma, also known as adenocarcinoma of ampulla of vater, is related to mucinous intrahepatic cholangiocarcinoma and chronic cholangitis, and has symptoms including abdominal pain, icterus and nausea. An important gene associated with Ampulla of Vater Adenocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Oxaliplatin and s 1 (combination) have been mentioned in the context of this disorder. Related phenotypes are cellular and digestive/alimentary

Related Diseases for Ampulla of Vater Adenocarcinoma

Diseases related to Ampulla of Vater Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 mucinous intrahepatic cholangiocarcinoma 10.8 CDX2 MUC2
2 chronic cholangitis 10.7 CDX2 MUC2
3 pancreatic intraductal papillary-mucinous neoplasm 10.7 MUC1 MUC2
4 tumor of exocrine pancreas 10.7 MUC1 MUC2
5 ovary neuroendocrine neoplasm 10.7 CDX2 KRT7
6 mucinous adenofibroma 10.7 CDX2 KRT7
7 anus adenocarcinoma 10.7 CDX2 KRT7
8 chronic ethmoiditis 10.7 MUC1 MUC2
9 hepatoid adenocarcinoma 10.7 CDX2 MUC1
10 polyposis, skin pigmentation, alopecia, and fingernail changes 10.7 CDX2 MUC2
11 microinvasive gastric cancer 10.7 CDX2 MUC2
12 tn polyagglutination syndrome 10.7 MUC1 MUC2
13 epithelial predominant wilms' tumor 10.7 CDX2 KRT7
14 bronchiolo-alveolar adenocarcinoma 10.6 CDX2 KRT7
15 solid adenocarcinoma with mucin production 10.6 KRT7 MUC1
16 nasal cavity adenocarcinoma 10.6 CDX2 KRT7
17 anal canal adenocarcinoma 10.6 CDX2 KRT7
18 endosalpingiosis 10.6 KRT7 MUC1
19 ethmoid sinusitis 10.6 MUC1 MUC2
20 parachordoma 10.6 KRT7 MUC1
21 middle ear adenoma 10.6 KRT7 MUC1
22 malignant mixed mullerian tumor 10.6 KRT7 MUC1
23 nodular hidradenoma 10.6 KRT7 MUC1
24 apocrine adenocarcinoma 10.6 KRT7 MUC1
25 monophasic synovial sarcoma 10.6 KRT7 MUC1
26 nephrogenic adenoma 10.6 KRT7 MUC1
27 adenomyoma 10.6 KRT7 MUC1
28 meconium ileus 10.6 MUC1 MUC2
29 spiradenoma 10.6 KRT7 MUC1
30 suppurative cholangitis 10.5 CDX2 MUC2
31 hidradenoma 10.5 KRT7 MUC1
32 well-differentiated liposarcoma 10.5 KRT7 MUC1
33 clear cell basal cell carcinoma 10.5 KRT17 KRT7
34 sertoli-leydig cell tumor 10.5 KRT7 MUC1
35 anus cancer 10.5 CDX2 KRT7
36 spindle cell sarcoma 10.5 KRT7 MUC1
37 sclerosing hemangioma 10.5 KRT7 MUC1
38 lipoadenoma 10.5 KRT7 MUC1
39 breast secretory carcinoma 10.5 KRT7 MUC1
40 adenocarcinoma 10.5
41 intestinal benign neoplasm 10.5 CDX2 MUC2
42 large cell acanthoma 10.5 KRT17 KRT7
43 pulmonary hemosiderosis 10.5 KRT7 MUC1
44 bowen's disease 10.5 KRT17 KRT7
45 colorectal cancer 1 10.5 MUC1 MUC2
46 intraneural perineurioma 10.5 KRT7 MUC1
47 pericardial mesothelioma 10.4 KRT7 MUC1
48 basaloid squamous cell carcinoma 10.4 KRT17 KRT7
49 epithelioid sarcoma 10.4 KRT7 MUC1
50 clear cell adenofibroma 10.4 BRCA2 KRT7

Graphical network of the top 20 diseases related to Ampulla of Vater Adenocarcinoma:



Diseases related to Ampulla of Vater Adenocarcinoma

Symptoms & Phenotypes for Ampulla of Vater Adenocarcinoma

UMLS symptoms related to Ampulla of Vater Adenocarcinoma:


abdominal pain, icterus, nausea, pruritus, vomiting, malaise

MGI Mouse Phenotypes related to Ampulla of Vater Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 BRCA2 CDX2 CTTN KRT17 KRT7 MUC2
2 digestive/alimentary MP:0005381 9.02 BRCA2 CDX2 KRT17 MUC2 SOX2

Drugs & Therapeutics for Ampulla of Vater Adenocarcinoma

Drugs for Ampulla of Vater Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
2
s 1 (combination) Phase 2
3
Gemcitabine Approved Phase 1 95058-81-4 60750
4
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
5 Immunosuppressive Agents Phase 1
6 Anti-Infective Agents Phase 1
7 Antimetabolites Phase 1
8 Antiviral Agents Phase 1
9 Antimetabolites, Antineoplastic Phase 1
10
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
11 pancreatin Not Applicable
12 Gastrointestinal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of S-1 Oxaliplatin (SOX) for Biliary Tract Cancer (BTC) (Ampullary Adenocarcinoma) Unknown status NCT01180153 Phase 2 S-1 oxaliplatin
2 ADH-1, Gemcitabine Hydrochloride and Cisplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic or Biliary Tract Cancer That Cannot Be Removed by Surgery Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
3 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Ampulla of Vater Adenocarcinoma

Genetic Tests for Ampulla of Vater Adenocarcinoma

Anatomical Context for Ampulla of Vater Adenocarcinoma

Publications for Ampulla of Vater Adenocarcinoma

Articles related to Ampulla of Vater Adenocarcinoma:

# Title Authors Year
1
Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. ( 25436120 )
2014
2
Ampulla of Vater Adenocarcinoma in a BRCA2 Germline Mutation Carrier. ( 23417715 )
2013
3
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma. ( 23030700 )
2013
4
Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review. ( 19444594 )
2009
5
Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. ( 16596179 )
2006
6
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. ( 15725805 )
2005
7
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. ( 14677066 )
2004
8
Skull metastasis from ampulla of Vater adenocarcinoma: case report. ( 15072455 )
2004
9
Cytokeratins 7, 17, and 20 reactivity in pancreatic and ampulla of vater adenocarcinomas. Percentage of positivity and distribution is affected by the cut-point threshold. ( 11345833 )
2001

Variations for Ampulla of Vater Adenocarcinoma

Expression for Ampulla of Vater Adenocarcinoma

Search GEO for disease gene expression data for Ampulla of Vater Adenocarcinoma.

Pathways for Ampulla of Vater Adenocarcinoma

Pathways related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT17 KRT20 KRT7
2 11.51 CTTN KRT17 KRT20 KRT7 MUC1
3 10.19 CDX2 SOX2

GO Terms for Ampulla of Vater Adenocarcinoma

Cellular components related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT17 KRT20 KRT7

Biological processes related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT17 KRT20 KRT7
2 positive regulation of cell differentiation GO:0045597 9.32 CDX2 SOX2
3 intermediate filament organization GO:0045109 9.16 KRT17 KRT20
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA2 MUC1
5 cornification GO:0070268 8.8 KRT17 KRT20 KRT7

Sources for Ampulla of Vater Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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