MCID: AMP009
MIFTS: 40

Ampulla of Vater Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ampulla of Vater Adenocarcinoma

MalaCards integrated aliases for Ampulla of Vater Adenocarcinoma:

Name: Ampulla of Vater Adenocarcinoma 12 15
Adenocarcinoma of Ampulla of Vater 12 73
Ampullary Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3502
NCIt 50 C6650
UMLS 73 C1332243

Summaries for Ampulla of Vater Adenocarcinoma

Disease Ontology : 12 An ampulla of Vater carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Ampulla of Vater Adenocarcinoma, also known as adenocarcinoma of ampulla of vater, is related to adenocarcinoma and suppurative cholangitis, and has symptoms including vomiting, abdominal pain and pruritus. An important gene associated with Ampulla of Vater Adenocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Oxaliplatin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lung and kidney, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Ampulla of Vater Adenocarcinoma

Diseases related to Ampulla of Vater Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.6
2 suppurative cholangitis 10.3 CDX2 MUC2
3 intestinal benign neoplasm 10.3 CDX2 MUC2
4 colorectal cancer 1 10.2 MUC1 MUC2
5 cholecystitis 10.2 MUC1 MUC2
6 mucinous intrahepatic cholangiocarcinoma 10.2 CDX2 MUC2
7 spindle cell carcinoma 10.2 KRT7 MUC1
8 adenosquamous carcinoma 10.2 KRT7 MUC1
9 epithelioid sarcoma 10.2 KRT7 MUC1
10 pericardial mesothelioma 10.2 KRT7 MUC1
11 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
12 tumor of exocrine pancreas 10.2 MUC1 MUC2
13 chronic cholangitis 10.2 CDX2 MUC2
14 pancreatic intraductal papillary-mucinous neoplasm 10.2 MUC1 MUC2
15 mucinous adenofibroma 10.2 CDX2 KRT7
16 anus adenocarcinoma 10.2 CDX2 KRT7
17 chronic ethmoiditis 10.2 MUC1 MUC2
18 hepatoid adenocarcinoma 10.2 CDX2 MUC1
19 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
20 primary cutaneous amyloidosis 10.2 KRT17 KRT7
21 nasal cavity cancer 10.2 CDX2 KRT7
22 solid adenocarcinoma with mucin production 10.2 KRT7 MUC1
23 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 CDX2 MUC2
24 endosalpingiosis 10.2 KRT7 MUC1
25 parachordoma 10.2 KRT7 MUC1
26 secretory meningioma 10.2 KRT7 MUC1
27 middle ear adenoma 10.2 KRT7 MUC1
28 nasal cavity adenocarcinoma 10.2 CDX2 KRT7
29 anal canal adenocarcinoma 10.2 CDX2 KRT7
30 nodular hidradenoma 10.2 KRT7 MUC1
31 hidradenoma 10.2 KRT7 MUC1
32 ethmoid sinusitis 10.2 MUC1 MUC2
33 monophasic synovial sarcoma 10.2 KRT7 MUC1
34 ovarian cancer 1 10.2 BRCA2 KRT7
35 clear cell basal cell carcinoma 10.2 KRT17 KRT7
36 adenomyoma 10.2 KRT7 MUC1
37 microinvasive gastric cancer 10.1 CDX2 MUC2
38 pre-malignant neoplasm 10.1 BRCA2 KRT17
39 well-differentiated liposarcoma 10.1 KRT7 MUC1
40 large cell acanthoma 10.1 KRT17 KRT7
41 sertoli-leydig cell tumor 10.1 KRT7 MUC1
42 spindle cell sarcoma 10.1 KRT7 MUC1
43 sclerosing hemangioma 10.1 KRT7 MUC1
44 vaginal benign neoplasm 10.1 CDX2 KRT20
45 lipoadenoma 10.1 KRT7 MUC1
46 bowen's disease 10.1 KRT17 KRT7
47 vaginal adenoma 10.1 CDX2 KRT20
48 vaginal tubulovillous adenoma 10.1 CDX2 KRT20
49 ovarian brenner tumor 10.1 KRT20 KRT7
50 inverted papilloma 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Ampulla of Vater Adenocarcinoma:



Diseases related to Ampulla of Vater Adenocarcinoma

Symptoms & Phenotypes for Ampulla of Vater Adenocarcinoma

UMLS symptoms related to Ampulla of Vater Adenocarcinoma:


vomiting, abdominal pain, pruritus, nausea, icterus, malaise

MGI Mouse Phenotypes related to Ampulla of Vater Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 BRCA2 CDX2 CTTN KRT17 KRT7 MUC2
2 digestive/alimentary MP:0005381 9.02 BRCA2 CDX2 KRT17 MUC2 SOX2

Drugs & Therapeutics for Ampulla of Vater Adenocarcinoma

Drugs for Ampulla of Vater Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
2
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
s 1 (combination) Phase 2
5 Immunoglobulin G Phase 2
6 Immunologic Factors Phase 2,Phase 1
7 Antimetabolites, Antineoplastic Phase 2,Phase 1
8 Antibodies Phase 2
9 Mitogens Phase 2
10 Antibodies, Monoclonal Phase 2
11 Immunoglobulins Phase 2
12 Endothelial Growth Factors Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Antimetabolites Phase 2,Phase 1
15 Angiogenesis Inhibitors Phase 2
16
Gemcitabine Approved Phase 1 95058-81-4 60750
17
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
18 Antiviral Agents Phase 1
19 Immunosuppressive Agents Phase 1
20 Anti-Infective Agents Phase 1
21
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
22 Gastrointestinal Agents Not Applicable
23 pancreatin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of S-1 Oxaliplatin (SOX) for Biliary Tract Cancer (BTC) (Ampullary Adenocarcinoma) Unknown status NCT01180153 Phase 2 S-1 oxaliplatin
2 Bevacizumab, Capecitabine, and Oxaliplatin in Treating Advanced Small Intestinal or Ampulla of Vater Adenocarcinoma Completed NCT01208103 Phase 2 Capecitabine;Oxaliplatin
3 ADH-1, Gemcitabine Hydrochloride and Cisplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic or Biliary Tract Cancer That Cannot Be Removed by Surgery Completed NCT01825603 Phase 1 ADH-1;Cisplatin;Gemcitabine Hydrochloride
4 Survival and Description of Care for Patients With Degenerate Vaterian Ampulloma Recruiting NCT03800212 treatment for ampullary adenocarcinoma
5 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Ampulla of Vater Adenocarcinoma

Genetic Tests for Ampulla of Vater Adenocarcinoma

Anatomical Context for Ampulla of Vater Adenocarcinoma

MalaCards organs/tissues related to Ampulla of Vater Adenocarcinoma:

41
Endothelial, Lung, Kidney, Ovary, Pancreas, Thymus, Appendix

Publications for Ampulla of Vater Adenocarcinoma

Articles related to Ampulla of Vater Adenocarcinoma:

# Title Authors Year
1
Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. ( 25436120 )
2014
2
Ampulla of Vater Adenocarcinoma in a BRCA2 Germline Mutation Carrier. ( 23417715 )
2013
3
The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma. ( 23030700 )
2013
4
Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review. ( 19444594 )
2009
5
Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. ( 16596179 )
2006
6
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. ( 14677066 )
2004
7
Skull metastasis from ampulla of Vater adenocarcinoma: case report. ( 15072455 )
2004
8
Composite carcinoid-adenocarcinoma of ampulla of Vater. ( 2227927 )
1990
9
[Adenocarcinoma of ampulla of Vater]. ( 15407174 )
1949
10
Liver abscess due to Friedlander's bacillus (K. pneumoniae) complicating adenocarcinoma of ampulla of Vater. ( 21010667 )
1945

Variations for Ampulla of Vater Adenocarcinoma

Expression for Ampulla of Vater Adenocarcinoma

Search GEO for disease gene expression data for Ampulla of Vater Adenocarcinoma.

Pathways for Ampulla of Vater Adenocarcinoma

Pathways related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT17 KRT20 KRT7
2 11.51 CTTN KRT17 KRT20 KRT7 MUC1
3 10.19 CDX2 SOX2

GO Terms for Ampulla of Vater Adenocarcinoma

Cellular components related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT17 KRT20 KRT7

Biological processes related to Ampulla of Vater Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT17 KRT20 KRT7
2 somatic stem cell population maintenance GO:0035019 9.37 CDX2 SOX2
3 positive regulation of cell differentiation GO:0045597 9.32 CDX2 SOX2
4 intermediate filament organization GO:0045109 9.16 KRT17 KRT20
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA2 MUC1
6 cornification GO:0070268 8.8 KRT17 KRT20 KRT7

Sources for Ampulla of Vater Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....