AMYL8
MCID: AMY082
MIFTS: 46

Amyloidosis, Familial Visceral (AMYL8)

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Bone diseases, Metabolic diseases, Neuronal diseases

Aliases & Classifications for Amyloidosis, Familial Visceral

MalaCards integrated aliases for Amyloidosis, Familial Visceral:

Name: Amyloidosis, Familial Visceral 57 73
Ostertag Type Amyloidosis 57 12 53 75
German Type Amyloidosis 57 12 53 75
Hereditary Amyloid Nephropathy 53 59 73
Familial Visceral Amyloidosis 12 75 15
Familial Amyloid Nephropathy 53 59 75
Familial Renal Amyloidosis 53 59 75
Amyloidosis Viii 57 53 75
Hereditary Amyloidosis with Primary Renal Involement 53 59
Amyloidosis, Systemic Nonneuropathic 57 55
Amyloidosis, 3 or More Types 57 13
Hereditary Renal Amyloidosis 53 59
Amyloidosis, Familial Renal 57 12
Amyloidosis, Ostertag Type 53 59
Amyloidosis 8 53 75
Systemic Non-Neuropathic Amyloidosis 75
Systemic Nonneuropathic Amyloidosis 12
Amyloidosis Systemic Nonneuropathic 53
Amyloidosis Familial Visceral 53
Amyloidosis Familial Renal 53
Amyloid Nephropathy 73
Amyloidosis, Renal 57
Renal Amyloidosis 55
Amyl8 75

Characteristics:

Orphanet epidemiological data:

59
hereditary amyloidosis with primary renal involement
Inheritance: Autosomal dominant; Age of onset: All ages;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
amyloidosis, familial visceral:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Amyloidosis, Familial Visceral

UniProtKB/Swiss-Prot : 75 Amyloidosis 8: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.

MalaCards based summary : Amyloidosis, Familial Visceral, also known as ostertag type amyloidosis, is related to al amyloidosis and amyloidosis, hereditary, transthyretin-related. An important gene associated with Amyloidosis, Familial Visceral is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Affiliated tissues include skin and bone, and related phenotypes are proteinuria and nephrotic syndrome

Description from OMIM: 105200

Related Diseases for Amyloidosis, Familial Visceral

Diseases related to Amyloidosis, Familial Visceral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 al amyloidosis 30.4 LYZ TTR
2 amyloidosis, hereditary, transthyretin-related 29.9 APOA1 GSN TTR
3 familial mediterranean fever 28.3 MEFV SAA1 SAA2 SAA4 TNFRSF1A
4 amyloidosis aa 26.8 APOA1 B2M LPA MEFV SAA1 SAA2
5 amyloidosis 24.5 APOA1 B2M FGA GSN IAPP LYZ
6 muckle-wells syndrome 11.3
7 familial lcat deficiency 10.8 APOA1 APOA2
8 tibial neuropathy 10.7 B2M TTR
9 tarsal tunnel syndrome 10.7 B2M TTR
10 median rhomboid glossitis 10.7 B2M TTR
11 erysipeloid 10.7 LYZ MEFV
12 oculogyric crisis 10.7 B2M FGA
13 fish-eye disease 10.7 APOA1 APOA2
14 diffuse glomerulonephritis 10.7 B2M LYZ
15 retinitis pigmentosa 7 10.5 B2M LYZ TTR
16 amyloidosis, finnish type 10.5 GSN TTR
17 nerve compression syndrome 10.5 B2M TTR
18 inflammatory myopathy with abundant macrophages 10.5 MEFV TNFRSF1A
19 intermittent hydrarthrosis 10.5 MEFV TNFRSF1A
20 amyloid tumor 10.5 B2M TTR
21 idiopathic recurrent pericarditis 10.4 MEFV TNFRSF1A
22 hyperlipoproteinemia, type iv 10.4 APOA1 APOA2
23 renal tuberculosis 10.4 B2M LYZ
24 immunodeficiency 43 10.4 B2M FCGRT
25 familial cold autoinflammatory syndrome 1 10.4 MEFV TNFRSF1A
26 amyloid neuropathy 10.3 APOA1 GSN TTR
27 pediatric multiple sclerosis 10.3 GSN TTR
28 hyper-igd syndrome 10.3 SAA1 TNFRSF1A
29 relapsing fever 10.3 MEFV TNFRSF1A
30 pyelitis 10.3 B2M LYZ
31 polyneuropathy 10.2 APOA1 GSN TTR
32 blepharochalasis 10.2 GSN SAA1 TTR
33 periodic fever, familial, autosomal dominant 10.2 LYZ MEFV TNFRSF1A
34 carotenemia 10.1 LPA TTR
35 lipoprotein glomerulopathy 9.9 APOA2 LPA
36 leukodystrophy, hypomyelinating, 3 9.9 APOA1 APOA2 LPA
37 hyperlipidemia, familial combined 9.9 APOA1 APOA2 LPA
38 hypolipoproteinemia 9.8 APOA1 APOA2 LPA
39 arcus corneae 9.8 APOA1 APOA2 LPA
40 lecithin:cholesterol acyltransferase deficiency 9.8 APOA1 APOA2 LPA
41 coronary heart disease 1 9.8 APOA1 APOA2 LPA
42 tangier disease 9.8 APOA1 APOA2 LPA
43 acute salpingitis 9.7 LYZ TNFRSF1A
44 hypercholesterolemia, familial 9.6 APOA1 APOA2 LPA
45 factor x deficiency 9.6
46 brucellosis 9.6
47 papillary carcinoma 9.6
48 peritonitis 9.6
49 ah amyloidosis 9.6
50 coronary artery anomaly 9.5 APOA1 APOA2 FGA LPA

Graphical network of the top 20 diseases related to Amyloidosis, Familial Visceral:



Diseases related to Amyloidosis, Familial Visceral

Symptoms & Phenotypes for Amyloidosis, Familial Visceral

Symptoms via clinical synopsis from OMIM:

57
Endocrine:
hypertension

Lab:
proteinuria
hematuria
generalized amyloid deposition

Skin:
pitting edema
petechial skin rash

Misc:
chronic weakness

GI:
splenomegaly
hepatomegaly
cholestasis

GU:
nephrotic syndrome
nephropathy with hematuria
uremia

Neuro:
nonneuropathic


Clinical features from OMIM:

105200

Human phenotypes related to Amyloidosis, Familial Visceral:

32 (show all 11)
# Description HPO Frequency HPO Source Accession
1 proteinuria 32 HP:0000093
2 nephrotic syndrome 32 HP:0000100
3 nephropathy 32 HP:0000112
4 hematuria 32 HP:0000790
5 hypertension 32 HP:0000822
6 edema 32 HP:0000969
7 skin rash 32 HP:0000988
8 cholestasis 32 HP:0001396
9 splenomegaly 32 HP:0001744
10 hepatomegaly 32 HP:0002240
11 generalized amyloid deposition 32 HP:0003216

MGI Mouse Phenotypes related to Amyloidosis, Familial Visceral:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 B2M FCGRT FGA GSN IAPP LYZ
2 hematopoietic system MP:0005397 9.97 B2M FCGRT FGA GSN IAPP LYZ
3 immune system MP:0005387 9.81 FCGRT FGA GSN IAPP LYZ MEFV
4 integument MP:0010771 9.56 APOA1 B2M FGA GSN LYZ MEFV
5 liver/biliary system MP:0005370 9.1 APOA1 B2M FGA LYZ MEFV TNFRSF1A

Drugs & Therapeutics for Amyloidosis, Familial Visceral

Search Clinical Trials , NIH Clinical Center for Amyloidosis, Familial Visceral

Genetic Tests for Amyloidosis, Familial Visceral

Anatomical Context for Amyloidosis, Familial Visceral

MalaCards organs/tissues related to Amyloidosis, Familial Visceral:

41
Skin, Bone

Publications for Amyloidosis, Familial Visceral

Articles related to Amyloidosis, Familial Visceral:

# Title Authors Year
1
A novel lysozyme mutation Phe57Ile associated with hereditary renal amyloidosis. ( 12675840 )
2003
2
Hereditary renal amyloidosis caused by a new variant lysozyme W64R in a French family. ( 11849445 )
2002
3
Hereditary renal amyloidosis associated with variant lysozyme in a large English family. ( 10534505 )
1999
4
Hereditary renal amyloidosis with a novel variant fibrinogen. ( 8113408 )
1994
5
Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. ( 8097946 )
1993

Variations for Amyloidosis, Familial Visceral

UniProtKB/Swiss-Prot genetic disease variations for Amyloidosis, Familial Visceral:

75
# Symbol AA change Variation ID SNP ID
1 APOA1 p.Gly50Arg VAR_000609 rs28931574
2 APOA1 p.Leu84Arg VAR_000610 rs121912724
3 B2M p.Asp96Asn VAR_076691 rs398122820
4 FGA p.Glu545Val VAR_010731 rs121909612
5 FGA p.Arg573Leu VAR_010732 rs78506343
6 LYZ p.Ile74Thr VAR_004280 rs121913547
7 LYZ p.Asp85His VAR_004281 rs121913548

ClinVar genetic disease variations for Amyloidosis, Familial Visceral:

6
(show top 50) (show all 145)
# Gene Variation Type Significance SNP ID Assembly Location
1 LYZ NM_000239.2(LYZ): c.221T> C (p.Ile74Thr) single nucleotide variant Pathogenic rs121913547 GRCh37 Chromosome 12, 69743972: 69743972
2 LYZ NM_000239.2(LYZ): c.221T> C (p.Ile74Thr) single nucleotide variant Pathogenic rs121913547 GRCh38 Chromosome 12, 69350192: 69350192
3 LYZ NM_000239.2(LYZ): c.199G> C (p.Asp67His) single nucleotide variant Pathogenic rs387906535 GRCh37 Chromosome 12, 69743950: 69743950
4 LYZ NM_000239.2(LYZ): c.199G> C (p.Asp67His) single nucleotide variant Pathogenic rs387906535 GRCh38 Chromosome 12, 69350170: 69350170
5 LYZ NM_000239.2(LYZ): c.244T> C (p.Trp82Arg) single nucleotide variant Pathogenic rs387906536 GRCh37 Chromosome 12, 69743995: 69743995
6 LYZ NM_000239.2(LYZ): c.244T> C (p.Trp82Arg) single nucleotide variant Pathogenic rs387906536 GRCh38 Chromosome 12, 69350215: 69350215
7 LYZ NM_000239.2(LYZ): c.223T> A (p.Phe75Ile) single nucleotide variant Pathogenic rs121913549 GRCh37 Chromosome 12, 69743974: 69743974
8 LYZ NM_000239.2(LYZ): c.223T> A (p.Phe75Ile) single nucleotide variant Pathogenic rs121913549 GRCh38 Chromosome 12, 69350194: 69350194
9 LYZ NM_000239.2(LYZ): c.244T> A (p.Trp82Arg) single nucleotide variant Pathogenic rs387906536 GRCh37 Chromosome 12, 69743995: 69743995
10 LYZ NM_000239.2(LYZ): c.244T> A (p.Trp82Arg) single nucleotide variant Pathogenic rs387906536 GRCh38 Chromosome 12, 69350215: 69350215
11 FGA NM_000508.4(FGA): c.1718G> T (p.Arg573Leu) single nucleotide variant Pathogenic rs78506343 GRCh37 Chromosome 4, 155506863: 155506863
12 FGA NM_000508.4(FGA): c.1718G> T (p.Arg573Leu) single nucleotide variant Pathogenic rs78506343 GRCh38 Chromosome 4, 154585711: 154585711
13 FGA NM_000508.4(FGA): c.1622delT (p.Val541Alafs) deletion Pathogenic rs587777761 GRCh38 Chromosome 4, 154585807: 154585807
14 FGA NM_000508.4(FGA): c.1622delT (p.Val541Alafs) deletion Pathogenic rs587777761 GRCh37 Chromosome 4, 155506959: 155506959
15 FGA NM_000508.4(FGA): c.1634A> T (p.Glu545Val) single nucleotide variant Pathogenic rs121909612 GRCh37 Chromosome 4, 155506947: 155506947
16 FGA NM_000508.4(FGA): c.1634A> T (p.Glu545Val) single nucleotide variant Pathogenic rs121909612 GRCh38 Chromosome 4, 154585795: 154585795
17 FGA NM_000508.4(FGA): c.1629delG (p.Thr544Leufs) deletion Pathogenic rs587777762 GRCh37 Chromosome 4, 155506952: 155506952
18 FGA NM_000508.4(FGA): c.1629delG (p.Thr544Leufs) deletion Pathogenic rs587777762 GRCh38 Chromosome 4, 154585800: 154585800
19 APOA1 NM_000039.2(APOA1): c.251T> G (p.Leu84Arg) single nucleotide variant Pathogenic rs121912724 GRCh37 Chromosome 11, 116707077: 116707077
20 APOA1 NM_000039.2(APOA1): c.251T> G (p.Leu84Arg) single nucleotide variant Pathogenic rs121912724 GRCh38 Chromosome 11, 116836361: 116836361
21 APOA1 APOA1, 12-BP DEL AND 2-BP INS indel Pathogenic
22 APOA1 NM_000039.2(APOA1): c.220T> C (p.Trp74Arg) single nucleotide variant Pathogenic rs121912726 GRCh37 Chromosome 11, 116707108: 116707108
23 APOA1 NM_000039.2(APOA1): c.220T> C (p.Trp74Arg) single nucleotide variant Pathogenic rs121912726 GRCh38 Chromosome 11, 116836392: 116836392
24 APOA1 NM_000039.2(APOA1): c.593T> C (p.Leu198Ser) single nucleotide variant Pathogenic rs121912729 GRCh37 Chromosome 11, 116706735: 116706735
25 APOA1 NM_000039.2(APOA1): c.593T> C (p.Leu198Ser) single nucleotide variant Pathogenic rs121912729 GRCh38 Chromosome 11, 116836019: 116836019
26 APOA1 NM_000039.2(APOA1): c.595G> C (p.Ala199Pro) single nucleotide variant Pathogenic rs121912730 GRCh37 Chromosome 11, 116706733: 116706733
27 APOA1 NM_000039.2(APOA1): c.595G> C (p.Ala199Pro) single nucleotide variant Pathogenic rs121912730 GRCh38 Chromosome 11, 116836017: 116836017
28 B2M NM_004048.2(B2M): c.286G> A (p.Asp96Asn) single nucleotide variant Pathogenic rs398122820 GRCh37 Chromosome 15, 45007839: 45007839
29 B2M NM_004048.2(B2M): c.286G> A (p.Asp96Asn) single nucleotide variant Pathogenic rs398122820 GRCh38 Chromosome 15, 44715641: 44715641
30 FGA NM_021871.3(FGA): c.616C> G (p.Gln206Glu) single nucleotide variant Uncertain significance rs560732073 GRCh38 Chromosome 4, 154586813: 154586813
31 FGA NM_021871.3(FGA): c.616C> G (p.Gln206Glu) single nucleotide variant Uncertain significance rs560732073 GRCh37 Chromosome 4, 155507965: 155507965
32 FGA NM_021871.3(FGA): c.1542T> C (p.Pro514=) single nucleotide variant Likely benign rs4766 GRCh38 Chromosome 4, 154585887: 154585887
33 FGA NM_021871.3(FGA): c.1542T> C (p.Pro514=) single nucleotide variant Likely benign rs4766 GRCh37 Chromosome 4, 155507039: 155507039
34 FGA NM_021871.3(FGA): c.1199C> T (p.Ser400Phe) single nucleotide variant Likely benign rs184635235 GRCh38 Chromosome 4, 154586230: 154586230
35 FGA NM_021871.3(FGA): c.1199C> T (p.Ser400Phe) single nucleotide variant Likely benign rs184635235 GRCh37 Chromosome 4, 155507382: 155507382
36 FGA NM_021871.3(FGA): c.450G> A (p.Gln150=) single nucleotide variant Uncertain significance rs368446857 GRCh37 Chromosome 4, 155508724: 155508724
37 FGA NM_021871.3(FGA): c.450G> A (p.Gln150=) single nucleotide variant Uncertain significance rs368446857 GRCh38 Chromosome 4, 154587572: 154587572
38 FGA NM_021871.3(FGA): c.1444G> A (p.Val482Met) single nucleotide variant Likely benign rs139146037 GRCh38 Chromosome 4, 154585985: 154585985
39 FGA NM_021871.3(FGA): c.1444G> A (p.Val482Met) single nucleotide variant Likely benign rs139146037 GRCh37 Chromosome 4, 155507137: 155507137
40 FGA NM_021871.3(FGA): c.1417G> A (p.Asp473Asn) single nucleotide variant Uncertain significance rs200378626 GRCh38 Chromosome 4, 154586012: 154586012
41 FGA NM_021871.3(FGA): c.1417G> A (p.Asp473Asn) single nucleotide variant Uncertain significance rs200378626 GRCh37 Chromosome 4, 155507164: 155507164
42 FGA NM_021871.3(FGA): c.919A> G (p.Asn307Asp) single nucleotide variant Uncertain significance rs750564329 GRCh38 Chromosome 4, 154586510: 154586510
43 FGA NM_021871.3(FGA): c.919A> G (p.Asn307Asp) single nucleotide variant Uncertain significance rs750564329 GRCh37 Chromosome 4, 155507662: 155507662
44 FGA NM_021871.3(FGA): c.904C> G (p.Pro302Ala) single nucleotide variant Likely benign rs200203992 GRCh38 Chromosome 4, 154586525: 154586525
45 FGA NM_021871.3(FGA): c.904C> G (p.Pro302Ala) single nucleotide variant Likely benign rs200203992 GRCh37 Chromosome 4, 155507677: 155507677
46 FGA NM_021871.3(FGA): c.765G> A (p.Pro255=) single nucleotide variant Uncertain significance rs779582722 GRCh38 Chromosome 4, 154586664: 154586664
47 FGA NM_021871.3(FGA): c.765G> A (p.Pro255=) single nucleotide variant Uncertain significance rs779582722 GRCh37 Chromosome 4, 155507816: 155507816
48 FGA NM_021871.3(FGA): c.666A> T (p.Pro222=) single nucleotide variant Uncertain significance rs886059151 GRCh38 Chromosome 4, 154586763: 154586763
49 FGA NM_021871.3(FGA): c.666A> T (p.Pro222=) single nucleotide variant Uncertain significance rs886059151 GRCh37 Chromosome 4, 155507915: 155507915
50 FGA NM_021871.3(FGA): c.346G> A (p.Asp116Asn) single nucleotide variant Uncertain significance rs886059153 GRCh38 Chromosome 4, 154588811: 154588811

Expression for Amyloidosis, Familial Visceral

Search GEO for disease gene expression data for Amyloidosis, Familial Visceral.

Pathways for Amyloidosis, Familial Visceral

Pathways related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 APOA1 B2M FGA GSN IAPP LYZ
2
Show member pathways
13.28 APOA1 B2M FGA GSN IAPP LYZ
3
Show member pathways
11.26 APOA1 SAA1 SAA2 SAA4
4
Show member pathways
11.2 APOA1 APOA2 LPA
5 10.78 APOA1 APOA2
6 10.43 APOA1 APOA2

GO Terms for Amyloidosis, Familial Visceral

Cellular components related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 APOA1 APOA2 B2M FGA GSN LYZ
2 extracellular region GO:0005576 9.93 APOA1 APOA2 B2M FGA GSN IAPP
3 cell surface GO:0009986 9.83 APOA1 B2M FGA PSEN1 TNFRSF1A
4 extracellular space GO:0005615 9.73 APOA1 APOA2 B2M FGA GSN IAPP
5 endoplasmic reticulum lumen GO:0005788 9.71 APOA1 APOA2 B2M FGA
6 blood microparticle GO:0072562 9.62 APOA1 APOA2 FGA GSN
7 very-low-density lipoprotein particle GO:0034361 9.49 APOA1 APOA2
8 endocytic vesicle lumen GO:0071682 9.48 APOA1 SAA1
9 chylomicron GO:0042627 9.46 APOA1 APOA2
10 spherical high-density lipoprotein particle GO:0034366 9.37 APOA1 APOA2
11 high-density lipoprotein particle GO:0034364 9.02 APOA1 APOA2 SAA1 SAA2 SAA4

Biological processes related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.91 B2M GSN LYZ PSEN1 TTR
2 lipid transport GO:0006869 9.79 APOA1 APOA2 LPA
3 cell chemotaxis GO:0060326 9.7 SAA1 SAA2 SAA4
4 retinoid metabolic process GO:0001523 9.67 APOA1 APOA2 TTR
5 cholesterol transport GO:0030301 9.63 APOA1 APOA2
6 cholesterol efflux GO:0033344 9.62 APOA1 APOA2
7 lipoprotein metabolic process GO:0042157 9.62 APOA1 APOA2
8 reverse cholesterol transport GO:0043691 9.61 APOA1 APOA2
9 high-density lipoprotein particle remodeling GO:0034375 9.6 APOA1 APOA2
10 high-density lipoprotein particle assembly GO:0034380 9.59 APOA1 APOA2
11 low-density lipoprotein particle remodeling GO:0034374 9.58 APOA2 LPA
12 phospholipid efflux GO:0033700 9.58 APOA1 APOA2
13 chylomicron assembly GO:0034378 9.57 APOA1 APOA2
14 positive regulation of cholesterol esterification GO:0010873 9.56 APOA1 APOA2
15 high-density lipoprotein particle clearance GO:0034384 9.55 APOA1 APOA2
16 chylomicron remodeling GO:0034371 9.54 APOA1 APOA2
17 positive chemotaxis GO:0050918 9.54 SAA1 SAA2 SAA4
18 acute-phase response GO:0006953 9.5 SAA1 SAA2 SAA4
19 peptidyl-methionine modification GO:0018206 9.48 APOA1 APOA2
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 APOA1 APOA2
21 regulation of intestinal cholesterol absorption GO:0030300 9.43 APOA1 APOA2
22 negative regulation of lipase activity GO:0060192 9.4 APOA1 APOA2
23 cellular protein metabolic process GO:0044267 9.32 APOA1 APOA2 B2M FGA GSN IAPP
24 protein oxidation GO:0018158 9.26 APOA1 APOA2
25 negative regulation of inflammatory response GO:0050728 9.26 APOA1 MEFV SAA1 TNFRSF1A
26 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.16 APOA1 APOA2

Molecular functions related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 APOA1 B2M IAPP LYZ MEFV TNFRSF1A
2 phosphatidylcholine binding GO:0031210 9.48 APOA1 APOA2
3 lipid transporter activity GO:0005319 9.46 APOA1 APOA2
4 cholesterol transporter activity GO:0017127 9.43 APOA1 APOA2
5 high-density lipoprotein particle binding GO:0008035 9.4 APOA1 APOA2
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOA2
7 lipase inhibitor activity GO:0055102 9.32 APOA1 APOA2
8 high-density lipoprotein particle receptor binding GO:0070653 9.16 APOA1 APOA2
9 apolipoprotein receptor binding GO:0034190 8.96 APOA1 APOA2
10 chemoattractant activity GO:0042056 8.8 SAA1 SAA2 SAA4

Sources for Amyloidosis, Familial Visceral

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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