ALS7
MCID: AMY089
MIFTS: 27

Amyotrophic Lateral Sclerosis 7 (ALS7)

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis 7

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis 7:

Name: Amyotrophic Lateral Sclerosis 7 56 12 52 13 71
Amyotrophic Lateral Sclerosis Type 7 12 52 15
Als7 56 12 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0060199
OMIM 56 608031
OMIM Phenotypic Series 56 PS105400
MedGen 41 C1842674
UMLS 71 C1842674

Summaries for Amyotrophic Lateral Sclerosis 7

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 20.

MalaCards based summary : Amyotrophic Lateral Sclerosis 7, also known as amyotrophic lateral sclerosis type 7, is related to amyotrophic lateral sclerosis 1 and amyotrophic lateral sclerosis 6 with or without frontotemporal dementia. An important gene associated with Amyotrophic Lateral Sclerosis 7 is ALS7 (Amyotrophic Lateral Sclerosis 7). Affiliated tissues include endothelial, brain and lung.

More information from OMIM: 608031 PS105400

Related Diseases for Amyotrophic Lateral Sclerosis 7

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12 Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17 Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15 Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 amyotrophic lateral sclerosis 1 27.7 SUGCT SPG11 SETX PRPH MPP5 DCTN1
2 amyotrophic lateral sclerosis 6 with or without frontotemporal dementia 10.4
3 amyotrophic lateral sclerosis 5, juvenile 10.2
4 amyotrophic lateral sclerosis 19 10.2 PRPH ALS2
5 spastic paraplegia 57, autosomal recessive 10.2 SPG11 ALS2
6 spastic paraplegia 64, autosomal recessive 10.1 SPG11 SETX ALS2
7 amyotrophic lateral sclerosis type 5 10.1 SPG11 SETX ALS2
8 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 10.1 SPG11 SETX ALS2
9 juvenile amyotrophic lateral sclerosis 10.1 SPG11 SETX ALS2
10 amyotrophic lateral sclerosis 20 10.1 SPG11 PRPH ALS2
11 spinocerebellar ataxia 2 10.1 SPG11 SETX ALS2
12 genetic motor neuron disease 10.0 SETX DCTN1
13 pseudobulbar palsy 10.0 CHMP2B ALS2
14 spastic paraplegia 4, autosomal dominant 10.0 SPG11 ALS2
15 distal hereditary motor neuropathies 10.0 SETX DCTN1
16 pontocerebellar hypoplasia, type 2e 10.0 CHMP2B ALS2
17 amyotrophic lateral sclerosis 21 9.9 SPG11 SETX PRPH ALS2
18 motor neuron disease 9.8 SETX DCTN1 ALS2
19 motor peripheral neuropathy 9.8 SPG11 SETX DCTN1
20 amyotrophic lateral sclerosis 16, juvenile 9.8 SPG11 SETX CHMP2B ALS2
21 amyotrophic lateral sclerosis 12 9.8 SPG11 SETX CHMP2B ALS2
22 amyotrophic lateral sclerosis 3 9.8 SUGCT ALS2
23 amyotrophic lateral sclerosis 11 9.8 SPG11 SETX CHMP2B ALS2
24 amyotrophic lateral sclerosis 9 9.8 SPG11 SETX ANG ALS2
25 amyotrophic lateral sclerosis type 6 9.7 SPG11 SETX ANG ALS2
26 amyotrophic lateral sclerosis type 14 9.7 SETX PRPH CHMP2B ALS2
27 amyotrophic lateral sclerosis 18 9.7 SETX PRPH CHMP2B ALS2
28 hemochromatosis, type 1 9.6 SPG11 SETX DCTN1 ALS2
29 amyotrophic lateral sclerosis type 15 9.5 SPG11 SETX PRPH CHMP2B ALS2
30 amyotrophic lateral sclerosis 17 9.5 SPG11 SETX PRPH CHMP2B ALS2
31 perry syndrome 9.4 DCTN1 CHMP2B
32 amyotrophic lateral sclerosis 8 9.4 SPG11 SETX CHMP2B ANG ALS2
33 charcot-marie-tooth disease 9.3 SPG11 SETX PRPH DCTN1 ALS2
34 dystonia 9.2 SETX DCTN1 CHMP2B ALS2
35 amyotrophic lateral sclerosis 4, juvenile 9.2 SUGCT SPG11 SETX ANG ALS2
36 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 8.9 SPG11 SETX DCTN1 CHMP2B ANG ALS2
37 lateral sclerosis 8.7 SPG11 SETX PRPH DCTN1 CHMP2B ANG

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis 7:



Diseases related to Amyotrophic Lateral Sclerosis 7

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis 7

Clinical features from OMIM:

608031

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis 7

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis 7

Genetic Tests for Amyotrophic Lateral Sclerosis 7

Anatomical Context for Amyotrophic Lateral Sclerosis 7

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis 7:

40
Endothelial, Brain, Lung

Publications for Amyotrophic Lateral Sclerosis 7

Articles related to Amyotrophic Lateral Sclerosis 7:

(show all 23)
# Title Authors PMID Year
1
EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force. 6
21914052 2012
2
Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. 56
12858291 2003
3
Amyotrophic Lateral Sclerosis Overview 6
20301623 2001
4
Feasibility of Lung Volume Recruitment in Early Neuromuscular Weakness: A Comparison Between Amyotrophic Lateral Sclerosis, Myotonic Dystrophy, and Postpolio Syndrome. 61
25845857 2015
5
CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. 61
22526019 2012
6
Frequency and expression of ALS and HWP1 genotypes in Candida albicans strains isolated from Mexican patients suffering from vaginal candidosis. 61
22429754 2012
7
Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. 61
22428031 2012
8
[Gene mutations in familial amyotrophic lateral sclerosis]. 61
21301041 2011
9
Ability of Candida albicans mutants to induce Staphylococcus aureus vancomycin resistance during polymicrobial biofilm formation. 61
20566760 2010
10
Property differences among the four major Candida albicans strain clades. 61
19151328 2009
11
Deletion of ALS5, ALS6 or ALS7 increases adhesion of Candida albicans to human vascular endothelial and buccal epithelial cells. 61
17654269 2007
12
Unequal contribution of ALS9 alleles to adhesion between Candida albicans and human vascular endothelial cells. 61
17600078 2007
13
Gene transcription studies of Candida albicans following infection of HEp2 epithelial cells. 61
16772226 2006
14
RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients. 61
16519012 2006
15
Construction and real-time RT-PCR validation of Candida albicans PALS-GFP reporter strains and their use in flow cytometry analysis of ALS gene expression in budding and filamenting cells. 61
15817774 2005
16
Comparison between Candida albicans agglutinin-like sequence gene expression patterns in human clinical specimens and models of vaginal candidiasis. 61
15731066 2005
17
RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. 61
14766904 2004
18
Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9. 61
14523127 2003
19
Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 is a hypermutable contingency locus. 61
12952872 2003
20
The ALS6 and ALS7 genes of Candida albicans. 61
10861907 2000
21
Arabidopsis mutants with increased sensitivity to aluminum. 61
8819866 1996
22
'Excitability changes of muscular responses to magnetic brain stimulation in patients with central motor disorders. 61
1714817 1991
23
Respiratory complications and their management in motor neuron disease. 61
2804610 1989

Variations for Amyotrophic Lateral Sclerosis 7

Expression for Amyotrophic Lateral Sclerosis 7

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis 7.

Pathways for Amyotrophic Lateral Sclerosis 7

GO Terms for Amyotrophic Lateral Sclerosis 7

Cellular components related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 9.13 SETX ANG ALS2
2 axon GO:0030424 9.02 SPG11 SETX MPP5 DCTN1 ALS2

Biological processes related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome organization GO:0007032 9.16 CHMP2B ALS2
2 neuromuscular junction development GO:0007528 8.96 DCTN1 ALS2
3 neuron cellular homeostasis GO:0070050 8.62 DCTN1 CHMP2B

Sources for Amyotrophic Lateral Sclerosis 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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