ALS7
MCID: AMY089
MIFTS: 27

Amyotrophic Lateral Sclerosis 7 (ALS7)

Categories: Genetic diseases, Mental diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis 7

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis 7:

Name: Amyotrophic Lateral Sclerosis 7 57 12 20 13 70
Amyotrophic Lateral Sclerosis Type 7 12 20 15
Als7 57 12 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0060199
OMIM® 57 608031
OMIM Phenotypic Series 57 PS105400
MedGen 41 C1842674
UMLS 70 C1842674

Summaries for Amyotrophic Lateral Sclerosis 7

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 20.

MalaCards based summary : Amyotrophic Lateral Sclerosis 7, also known as amyotrophic lateral sclerosis type 7, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 7 and spastic paraplegia 57, autosomal recessive. An important gene associated with Amyotrophic Lateral Sclerosis 7 is ALS7 (Amyotrophic Lateral Sclerosis 7), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include endothelial and brain.

More information from OMIM: 608031 PS105400

Related Diseases for Amyotrophic Lateral Sclerosis 7

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 16, Juvenile Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 12
Amyotrophic Lateral Sclerosis Type 14 Amyotrophic Lateral Sclerosis Type 15
Amyotrophic Lateral Sclerosis Type 22 Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 frontotemporal dementia and/or amyotrophic lateral sclerosis 7 11.6
2 spastic paraplegia 57, autosomal recessive 10.2 SPG11 ALS2
3 amyotrophic lateral sclerosis 19 10.1 PRPH ALS2
4 amyotrophic lateral sclerosis 3 10.1 SUGCT ALS2
5 amyotrophic lateral sclerosis 20 10.1 PRPH ALS2
6 spastic paraplegia 7, autosomal recessive 10.1 SPG11 SETX
7 amyotrophic lateral sclerosis 6 with or without frontotemporal dementia 10.1
8 spastic paraplegia 4, autosomal dominant 10.1 SPG11 ALS2
9 spinal muscular atrophy with lower extremity predominance 10.1 VAPB SETX
10 juvenile amyotrophic lateral sclerosis 10.0 SPG11 SETX ALS2
11 proximal spinal muscular atrophy 10.0 VAPB SETX
12 amyotrophic lateral sclerosis 5, juvenile 9.9
13 progressive bulbar palsy 9.9 VAPB SETX ALS2
14 motor peripheral neuropathy 9.8 SPG11 SETX
15 progressive muscular atrophy 9.8 VAPB CHMP2B
16 spinal muscular atrophy, distal, autosomal recessive, 4 9.8 SPG11 SETX ANG ALS2
17 spinocerebellar ataxia 2 9.7 VAPB SPG11 SETX ALS2
18 hemochromatosis, type 1 9.7 VAPB SPG11 SETX ALS2
19 amyotrophic lateral sclerosis 21 9.7 VAPB SETX PRPH ALS2
20 charcot-marie-tooth disease 9.6 SPG11 SETX PRPH ALS2
21 motor neuron disease 9.6 VAPB SETX CHMP2B ALS2
22 amyotrophic lateral sclerosis 8 9.5 VAPB SPG11 SETX ANG ALS2
23 amyotrophic lateral sclerosis 9 9.5 VAPB SPG11 SETX ANG ALS2
24 amyotrophic lateral sclerosis type 14 9.4 VAPB SPG11 SETX CHMP2B ALS2
25 amyotrophic lateral sclerosis 11 9.4 VAPB SPG11 SETX CHMP2B ALS2
26 amyotrophic lateral sclerosis 18 9.4 VAPB SETX PRPH CHMP2B ALS2
27 amyotrophic lateral sclerosis type 5 9.3 VAPB SUGCT SPG11 SETX ANG ALS2
28 amyotrophic lateral sclerosis 4, juvenile 9.3 VAPB SUGCT SPG11 SETX ANG ALS2
29 amyotrophic lateral sclerosis type 15 9.2 VAPB SPG11 SETX PRPH CHMP2B ALS2
30 amyotrophic lateral sclerosis 16, juvenile 9.2 VAPB SPG11 SETX PRPH CHMP2B ALS2
31 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 9.2 VAPB SPG11 SETX CHMP2B ANG ALS2
32 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.1 VAPB SPG11 SETX CHMP2B ANG ALS2
33 amyotrophic lateral sclerosis type 6 9.0 VAPB SUGCT SPG11 SETX CHMP2B ANG
34 amyotrophic lateral sclerosis type 12 9.0 VAPB SPG11 SNORD84 SETX CHMP2B ANG
35 lateral sclerosis 8.9 VAPB SPG11 SETX PRPH CHMP2B ANG
36 disease of mental health 8.9 VAPB SPG11 SETX PALS1 CHMP2B ALS2
37 amyotrophic lateral sclerosis 1 8.2 WAPL VAPB SUGCT SPG11 SETX PRPH

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis 7:



Diseases related to Amyotrophic Lateral Sclerosis 7

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis 7

Clinical features from OMIM®:

608031 (Updated 05-Apr-2021)

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis 7

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis 7

Genetic Tests for Amyotrophic Lateral Sclerosis 7

Anatomical Context for Amyotrophic Lateral Sclerosis 7

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis 7:

40
Endothelial, Brain

Publications for Amyotrophic Lateral Sclerosis 7

Articles related to Amyotrophic Lateral Sclerosis 7:

(show all 24)
# Title Authors PMID Year
1
Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. 57
12858291 2003
2
The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes. 61
33538224 2021
3
Non-invasive measurement of fasciculation frequency demonstrates diagnostic accuracy in amyotrophic lateral sclerosis. 61
33543131 2020
4
Feasibility of Lung Volume Recruitment in Early Neuromuscular Weakness: A Comparison Between Amyotrophic Lateral Sclerosis, Myotonic Dystrophy, and Postpolio Syndrome. 61
25845857 2015
5
CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. 61
22526019 2012
6
Frequency and expression of ALS and HWP1 genotypes in Candida albicans strains isolated from Mexican patients suffering from vaginal candidosis. 61
22429754 2012
7
Mutational loss of Arabidopsis SLOW WALKER2 results in reduced endogenous spermine concomitant with increased aluminum sensitivity. 61
32481087 2012
8
Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. 61
22428031 2012
9
[Gene mutations in familial amyotrophic lateral sclerosis]. 61
21301041 2011
10
Ability of Candida albicans mutants to induce Staphylococcus aureus vancomycin resistance during polymicrobial biofilm formation. 61
20566760 2010
11
Property differences among the four major Candida albicans strain clades. 61
19151328 2009
12
Deletion of ALS5, ALS6 or ALS7 increases adhesion of Candida albicans to human vascular endothelial and buccal epithelial cells. 61
17654269 2007
13
Unequal contribution of ALS9 alleles to adhesion between Candida albicans and human vascular endothelial cells. 61
17600078 2007
14
Gene transcription studies of Candida albicans following infection of HEp2 epithelial cells. 61
16772226 2006
15
RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients. 61
16519012 2006
16
Construction and real-time RT-PCR validation of Candida albicans PALS-GFP reporter strains and their use in flow cytometry analysis of ALS gene expression in budding and filamenting cells. 61
15817774 2005
17
Comparison between Candida albicans agglutinin-like sequence gene expression patterns in human clinical specimens and models of vaginal candidiasis. 61
15731066 2005
18
RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. 61
14766904 2004
19
Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9. 61
14523127 2003
20
Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 is a hypermutable contingency locus. 61
12952872 2003
21
The ALS6 and ALS7 genes of Candida albicans. 61
10861907 2000
22
Arabidopsis mutants with increased sensitivity to aluminum. 61
8819866 1996
23
'Excitability changes of muscular responses to magnetic brain stimulation in patients with central motor disorders. 61
1714817 1991
24
Respiratory complications and their management in motor neuron disease. 61
2804610 1989

Variations for Amyotrophic Lateral Sclerosis 7

Expression for Amyotrophic Lateral Sclerosis 7

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis 7.

Pathways for Amyotrophic Lateral Sclerosis 7

Pathways related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 VAPB SPG11 SETX PRPH CHMP2B ANG
2 10.54 PRPH ALS2

GO Terms for Amyotrophic Lateral Sclerosis 7

Cellular components related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 9.13 SETX ANG ALS2
2 axon GO:0030424 9.02 SPG11 SETX PRPH PALS1 ALS2

Biological processes related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome organization GO:0007032 8.62 CHMP2B ALS2

Sources for Amyotrophic Lateral Sclerosis 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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