ALS7
MCID: AMY089
MIFTS: 27

Amyotrophic Lateral Sclerosis 7 (ALS7)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis 7

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis 7:

Name: Amyotrophic Lateral Sclerosis 7 58 12 54 13 74
Amyotrophic Lateral Sclerosis Type 7 12 54 15
Als7 58 12 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0060199
OMIM 58 608031
MedGen 43 C1842674
UMLS 74 C1842674

Summaries for Amyotrophic Lateral Sclerosis 7

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 20.

MalaCards based summary : Amyotrophic Lateral Sclerosis 7, also known as amyotrophic lateral sclerosis type 7, is related to amyotrophic lateral sclerosis 1 and perrault syndrome 1. An important gene associated with Amyotrophic Lateral Sclerosis 7 is ALS7 (Amyotrophic Lateral Sclerosis 7). Related phenotypes are behavior/neurological and immune system

Description from OMIM: 608031

Related Diseases for Amyotrophic Lateral Sclerosis 7

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12 Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17 Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15 Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 amyotrophic lateral sclerosis 1 29.6 ALS2 ANG CTSC DAO FIG4 FUS
2 perrault syndrome 1 11.1
3 amyotrophic lateral sclerosis 5, juvenile 10.2
4 amyotrophic lateral sclerosis 4, juvenile 10.1 ALS2 DAO SETX
5 brown-vialetto-van laere syndrome 10.1 ALS2 TARDBP
6 expressive language disorder 9.9 FUS TARDBP
7 amyotrophic lateral sclerosis 18 9.9 FUS TARDBP
8 lethal congenital contracture syndrome 1 9.9 FUS TARDBP
9 juvenile amyotrophic lateral sclerosis 9.9 ALS2 FUS SETX
10 anterior horn cell disease 9.9 FUS TARDBP
11 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.8 FUS TARDBP
12 spinocerebellar ataxia 31 9.8 FUS SETX TARDBP
13 amyotrophic lateral sclerosis type 14 9.8 FUS OPTN TARDBP
14 ocular hypertension 9.7 FOS OPTN
15 pick disease of brain 9.7 FUS TARDBP
16 amyotrophic lateral sclerosis 21 9.6 FUS OPTN SETX TARDBP
17 amyotrophic lateral sclerosis type 6 9.5 ALS2 DAO FUS SETX TARDBP
18 motor neuron disease 9.4 ALS2 FUS OPTN SETX TARDBP
19 lateral sclerosis 9.1 ALS2 ANG FIG4 FUS OPTN SETX
20 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 8.9 ALS2 ANG DAO FIG4 FUS OPTN
21 amyotrophic lateral sclerosis 11 8.9 ALS2 ANG DAO FIG4 FUS OPTN
22 amyotrophic lateral sclerosis 9 7.6 ALS2 ANG CTSC DAO DUSP1 FIG4

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis 7:



Diseases related to Amyotrophic Lateral Sclerosis 7

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis 7

Clinical features from OMIM:

608031

MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis 7:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 ALS2 CTSC DAO DUSP1 FIG4 FOS
2 immune system MP:0005387 9.61 ALS2 CTSC DUSP1 FIG4 FOS MPP5
3 nervous system MP:0003631 9.23 ALS2 CTSC DAO DUSP1 FIG4 FOS

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis 7

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis 7

Genetic Tests for Amyotrophic Lateral Sclerosis 7

Anatomical Context for Amyotrophic Lateral Sclerosis 7

Publications for Amyotrophic Lateral Sclerosis 7

Variations for Amyotrophic Lateral Sclerosis 7

Expression for Amyotrophic Lateral Sclerosis 7

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis 7.

Pathways for Amyotrophic Lateral Sclerosis 7

GO Terms for Amyotrophic Lateral Sclerosis 7

Cellular components related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 8.8 ALS2 ANG SETX

Biological processes related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hormone stimulus GO:0032870 9.32 DUSP1 FOS
2 response to cAMP GO:0051591 9.26 DUSP1 FOS
3 cell death GO:0008219 9.16 ALS2 OPTN
4 response to light stimulus GO:0009416 8.96 DUSP1 FOS
5 myelin assembly GO:0032288 8.62 FIG4 MPP5

Molecular functions related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 ALS2 ANG CTSC DAO DUSP1 FIG4
2 identical protein binding GO:0042802 9.35 CTSC FUS OPTN SETX TARDBP

Sources for Amyotrophic Lateral Sclerosis 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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