ALS7
MCID: AMY089
MIFTS: 28

Amyotrophic Lateral Sclerosis 7 (ALS7)

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis 7

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis 7:

Name: Amyotrophic Lateral Sclerosis 7 57 12 53 13 73
Amyotrophic Lateral Sclerosis Type 7 12 53 15
Als7 57 12 53

Classifications:



External Ids:

OMIM 57 608031
Disease Ontology 12 DOID:0060199
MedGen 42 C1842674
UMLS 73 C1842674

Summaries for Amyotrophic Lateral Sclerosis 7

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 20.

MalaCards based summary : Amyotrophic Lateral Sclerosis 7, also known as amyotrophic lateral sclerosis type 7, is related to amyotrophic lateral sclerosis 1 and perrault syndrome 1. An important gene associated with Amyotrophic Lateral Sclerosis 7 is ALS7 (Amyotrophic Lateral Sclerosis 7). Affiliated tissues include brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Description from OMIM: 608031

Related Diseases for Amyotrophic Lateral Sclerosis 7

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12 Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17 Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15 Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 amyotrophic lateral sclerosis 1 29.7 ALS2 ALS7 ANG BCR CTSC DAO
2 perrault syndrome 1 11.1
3 amyotrophic lateral sclerosis 5, juvenile 10.1
4 amyotrophic lateral sclerosis 20 10.1 ALS2 MRPS22
5 amyotrophic lateral sclerosis 4, juvenile 10.1 ALS2 DAO SETX
6 denture stomatitis 10.1 BCR GFM1
7 amyotrophic lateral sclerosis 3 10.1 ALS2 BCR GFM1
8 juvenile amyotrophic lateral sclerosis 10.0 ALS2 FUS SETX
9 expressive language disorder 10.0 FUS TARDBP
10 amyotrophic lateral sclerosis 18 9.9 FUS TARDBP
11 lethal congenital contracture syndrome 1 9.9 FUS TARDBP
12 spinocerebellar ataxia 31 9.9 FUS SETX TARDBP
13 brown-vialetto-van laere syndrome 9.9 ALS2 TARDBP
14 anterior horn cell disease 9.9 FUS TARDBP
15 amyotrophic lateral sclerosis type 14 9.8 FUS OPTN TARDBP
16 amyotrophic lateral sclerosis type 6 9.7 ALS2 DAO FUS SETX TARDBP
17 amyotrophic lateral sclerosis 21 9.7 FUS OPTN SETX TARDBP
18 motor neuron disease 9.6 ALS2 FUS OPTN SETX TARDBP
19 lateral sclerosis 9.4 ALS2 ANG FIG4 FUS OPTN SETX
20 amyotrophic lateral sclerosis 11 9.3 ALS2 ANG DAO FIG4 FUS OPTN
21 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 9.2 ALS2 ANG DAO FIG4 FUS MRPS22
22 amyotrophic lateral sclerosis 9 8.3 ALS2 ANG BCR CTSC DAO DUSP1

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis 7:



Diseases related to Amyotrophic Lateral Sclerosis 7

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis 7

Clinical features from OMIM:

608031

MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis 7:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ALS2 BCR CTSC DAO DUSP1 FIG4
2 homeostasis/metabolism MP:0005376 9.85 ALS2 BCR CTSC DAO DUSP1 FOS
3 immune system MP:0005387 9.65 ALS2 BCR CTSC DUSP1 FIG4 FOS
4 nervous system MP:0003631 9.28 ALS2 BCR CTSC DAO DUSP1 FIG4

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis 7

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis 7

Genetic Tests for Amyotrophic Lateral Sclerosis 7

Anatomical Context for Amyotrophic Lateral Sclerosis 7

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis 7:

41
Brain

Publications for Amyotrophic Lateral Sclerosis 7

Variations for Amyotrophic Lateral Sclerosis 7

Expression for Amyotrophic Lateral Sclerosis 7

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis 7.

Pathways for Amyotrophic Lateral Sclerosis 7

GO Terms for Amyotrophic Lateral Sclerosis 7

Cellular components related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 8.8 ALS2 ANG SETX

Biological processes related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell death GO:0008219 9.16 ALS2 OPTN
2 response to light stimulus GO:0009416 8.96 DUSP1 FOS
3 myelin assembly GO:0032288 8.62 FIG4 MPP5

Molecular functions related to Amyotrophic Lateral Sclerosis 7 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 ALS2 ANG BCR CTSC DAO DUSP1

Sources for Amyotrophic Lateral Sclerosis 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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