Amyotrophic Lateral Sclerosis Type 14 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Amyotrophic Lateral Sclerosis Type 14

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis Type 14:

Name: Amyotrophic Lateral Sclerosis Type 14 ¹² ¹⁵

Amyotrophic Lateral Sclerosis 14 with or Without Frontotemporal Dementia ⁷³

Amyotrophic Lateral Sclerosis, with or Without Frontotemporal Dementia ¹²

Amyotrophic Lateral Sclerosis 14 ¹²

Als14 ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060205

UMLS ⁷³ C3151403

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Summaries for Amyotrophic Lateral Sclerosis Type 14

Disease Ontology : ¹² An amyotrophic lateral sclerosis that has material basis in mutation in the VCP gene on chromosome 9.

MalaCards based summary : Amyotrophic Lateral Sclerosis Type 14, also known as amyotrophic lateral sclerosis 14 with or without frontotemporal dementia, is related to amyotrophic lateral sclerosis 14 with or without frontotemporal dementia and bronchopneumonia. An important gene associated with Amyotrophic Lateral Sclerosis Type 14 is UBQLN2 (Ubiquilin 2), and among its related pathways/superpathways are TBC/RABGAPs and Mitophagy - animal.

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Related Diseases for Amyotrophic Lateral Sclerosis Type 14

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile	Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21	Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7	Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9	Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12	Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17	Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20	Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23	Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25	Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15	Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis Type 14 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)

#	Related Disease	Score	Top Affiliating Genes
1	amyotrophic lateral sclerosis 14 with or without frontotemporal dementia	11.8
2	bronchopneumonia	10.4	VAPA VAPB
3	postpoliomyelitis syndrome	10.3	TARDBP VCP
4	inclusion body myopathy with paget disease of bone and frontotemporal dementia	10.3	TARDBP VCP
5	amyotrophic lateral sclerosis 8	10.3	FAF1 VAPA VAPB
6	expressive language disorder	10.3	FUS TARDBP
7	amyotrophic lateral sclerosis 12	10.2	A1BG OPTN
8	amyotrophic lateral sclerosis type 6	10.2	FUS TARDBP
9	amyotrophic lateral sclerosis 18	10.2	FUS TARDBP
10	brown-vialetto-van laere syndrome	10.2	TARDBP UBQLN2
11	lethal congenital contracture syndrome 1	10.2	FUS TARDBP
12	anterior horn cell disease	10.0	FUS TARDBP
13	visual epilepsy	10.0	GABARAPL2 VAPA
14	nominal aphasia	9.9	FUS TARDBP VCP
15	ideomotor apraxia	9.9	FUS TARDBP
16	amyotrophic lateral sclerosis 7	9.9	FUS OPTN TARDBP
17	amyotrophic lateral sclerosis 9	9.9	FUS OPTN TARDBP
18	amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	9.9	FUS OPTN TARDBP
19	spinocerebellar ataxia 31	9.8	FUS TARDBP
20	nervous system disease	9.8	FUS OPTN TARDBP
21	basal ganglia disease	9.6	FUS TARDBP UBQLN2 VCP
22	frontotemporal dementia and/or amyotrophic lateral sclerosis 1	9.6	FUS TARDBP UBQLN2 VCP
23	frontotemporal dementia	9.6	FUS TARDBP UBQLN2 VCP
24	dementia	9.6	FUS TARDBP UBQLN2 VCP
25	pick disease of brain	9.6	FUS TARDBP
26	amyotrophic lateral sclerosis 11	9.3	A1BG FUS OPTN TARDBP
27	amyotrophic lateral sclerosis 21	9.2	FUS OPTN TARDBP VAPB VCP
28	motor neuron disease	9.2	FUS OPTN TARDBP VAPB VCP
29	lateral sclerosis	8.9	FUS OPTN TARDBP UBQLN2 VAPB VCP
30	amyotrophic lateral sclerosis 1	7.8	A1BG FUS OPTN TARDBP UBQLN2 VAPA

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis Type 14:

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Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis Type 14

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Drugs & Therapeutics for Amyotrophic Lateral Sclerosis Type 14

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis Type 14

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Genetic Tests for Amyotrophic Lateral Sclerosis Type 14

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Anatomical Context for Amyotrophic Lateral Sclerosis Type 14

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Publications for Amyotrophic Lateral Sclerosis Type 14

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Genes for Amyotrophic Lateral Sclerosis Type 14

Genes related to Amyotrophic Lateral Sclerosis Type 14 (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	UBQLN2	Ubiquilin 2	Protein Coding	16.71	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	FAF1	Fas Associated Factor 1	Protein Coding	16.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	VAPB	VAMP Associated Protein B And C	Protein Coding	15.87	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	VCP	Valosin Containing Protein	Protein Coding	15.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	VAPA	VAMP Associated Protein A	Protein Coding	15.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	OPTN	Optineurin	Protein Coding	14.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	FUS	FUS RNA Binding Protein	Protein Coding	14.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	TARDBP	TAR DNA Binding Protein	Protein Coding	14.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	ASNA1	ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial)	Protein Coding	6.84	DISEASES inferred ¹⁵
10	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	5.86	DISEASES inferred ¹⁵
11	GABARAPL1	GABA Type A Receptor Associated Protein Like 1	Protein Coding	5.74	DISEASES inferred ¹⁵
12	A1BG	Alpha-1-B Glycoprotein	Protein Coding	5.15	DISEASES inferred ¹⁵

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Variations for Amyotrophic Lateral Sclerosis Type 14

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Expression for Amyotrophic Lateral Sclerosis Type 14

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis Type 14.

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Pathways for Amyotrophic Lateral Sclerosis Type 14

Pathways related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TBC/RABGAPs ⁶⁶	10.63	GABARAPL2 OPTN
2	Mitophagy - animal ³⁷	10.61	GABARAPL1 GABARAPL2 OPTN

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GO Terms for Amyotrophic Lateral Sclerosis Type 14

Cellular components related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.96	ASNA1 FAF1 FUS GABARAPL1 GABARAPL2 OPTN
2	cytoplasmic vesicle	GO:0031410	9.73	GABARAPL1 GABARAPL2 OPTN UBQLN2
3	Golgi membrane	GO:0000139	9.71	GABARAPL2 OPTN VAPA VAPB
4	autophagosome membrane	GO:0000421	9.37	GABARAPL1 GABARAPL2
5	perinuclear region of cytoplasm	GO:0048471	9.35	FAF1 FUS OPTN VAPA VCP
6	endoplasmic reticulum exit site	GO:0070971	9.32	VAPA VAPB
7	VCP-NPL4-UFD1 AAA ATPase complex	GO:0034098	9.16	FAF1 VCP
8	autophagosome	GO:0005776	8.92	GABARAPL1 GABARAPL2 OPTN UBQLN2

Biological processes related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	ER to Golgi vesicle-mediated transport	GO:0006888	9.61	VAPA VAPB VCP
2	sphingolipid biosynthetic process	GO:0030148	9.51	VAPA VAPB
3	macroautophagy	GO:0016236	9.5	GABARAPL1 GABARAPL2 VCP
4	endoplasmic reticulum unfolded protein response	GO:0030968	9.49	VAPB VCP
5	autophagy of mitochondrion	GO:0000422	9.48	GABARAPL1 GABARAPL2
6	endoplasmic reticulum organization	GO:0007029	9.46	VAPA VAPB
7	positive regulation of protein complex assembly	GO:0031334	9.4	FAF1 VCP
8	cellular response to nitrogen starvation	GO:0006995	9.37	GABARAPL1 GABARAPL2
9	cell death	GO:0008219	9.33	FAF1 OPTN VAPA
10	COPII-coated vesicle budding	GO:0090114	9.26	VAPA VAPB
11	autophagosome maturation	GO:0097352	9.13	GABARAPL1 GABARAPL2 VCP
12	autophagy	GO:0006914	9.02	GABARAPL1 GABARAPL2 OPTN UBQLN2 VCP

Molecular functions related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein domain specific binding	GO:0019904	9.58	FAF1 VAPA VCP
2	microtubule binding	GO:0008017	9.54	GABARAPL2 VAPA VAPB
3	ubiquitin protein ligase binding	GO:0031625	9.46	FAF1 GABARAPL1 GABARAPL2 VCP
4	polyubiquitin modification-dependent protein binding	GO:0031593	9.32	OPTN VCP
5	GABA receptor binding	GO:0050811	9.26	GABARAPL1 GABARAPL2
6	beta-tubulin binding	GO:0048487	9.13	GABARAPL1 GABARAPL2 VAPB
7	FFAT motif binding	GO:0033149	8.62	VAPA VAPB

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Sources for Amyotrophic Lateral Sclerosis Type 14

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

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⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia