ALS14
MCID: AMY074
MIFTS: 21

Amyotrophic Lateral Sclerosis Type 14 (ALS14)

Categories: Genetic diseases, Mental diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis Type 14

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis Type 14:

Name: Amyotrophic Lateral Sclerosis Type 14 12 15
Amyotrophic Lateral Sclerosis 14 with or Without Frontotemporal Dementia 71
Amyotrophic Lateral Sclerosis, with or Without Frontotemporal Dementia 12
Amyotrophic Lateral Sclerosis 14 12
Als14 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060205
UMLS 71 C3151403

Summaries for Amyotrophic Lateral Sclerosis Type 14

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in the VCP gene on chromosome 9.

MalaCards based summary : Amyotrophic Lateral Sclerosis Type 14, also known as amyotrophic lateral sclerosis 14 with or without frontotemporal dementia, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 6 and progressive non-fluent aphasia. An important gene associated with Amyotrophic Lateral Sclerosis Type 14 is VCP (Valosin Containing Protein), and among its related pathways/superpathways is Pathways of neurodegeneration - multiple diseases.

Related Diseases for Amyotrophic Lateral Sclerosis Type 14

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 16, Juvenile Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 12
Amyotrophic Lateral Sclerosis Type 14 Amyotrophic Lateral Sclerosis Type 15
Amyotrophic Lateral Sclerosis Type 22 Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis Type 14 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 frontotemporal dementia and/or amyotrophic lateral sclerosis 6 11.4
2 progressive non-fluent aphasia 10.2 VCP CHMP2B
3 amyotrophic lateral sclerosis 6 with or without frontotemporal dementia 10.2 VCP FUS
4 amyotrophic lateral sclerosis 19 10.2 UBQLN2 ALS2
5 dyscalculia 10.2 VCP CHMP2B
6 amyotrophic lateral sclerosis 20 10.1 FIG4 ALS2
7 dysgraphia 10.1 FUS CHMP2B
8 spinal muscular atrophy with lower extremity predominance 10.1 VAPB SETX
9 perry syndrome 10.1 VCP CHMP2B
10 associative agnosia 10.1 VCP FUS CHMP2B
11 proximal spinal muscular atrophy 10.1 VAPB SETX
12 nominal aphasia 10.1 VCP FUS CHMP2B
13 writing disorder 10.1 VCP FUS CHMP2B
14 frontotemporal dementia and/or amyotrophic lateral sclerosis 7 10.0 VCP FUS CHMP2B
15 supranuclear palsy, progressive, 1 10.0 VCP FUS CHMP2B
16 spastic paraplegia 57, autosomal recessive 10.0 SPG11 ALS2
17 dementia, lewy body 10.0 VCP FUS CHMP2B
18 dermatopathia pigmentosa reticularis 10.0 UBQLN2 FUS
19 speech and communication disorders 10.0 VCP FUS CHMP2B
20 dementia 10.0 VCP UBQLN2 FUS CHMP2B
21 spastic paraplegia 7, autosomal recessive 9.9 SPG11 SETX
22 inclusion body myopathy with paget disease of bone and frontotemporal dementia 9.9 VCP UBQLN2 FUS CHMP2B
23 amyotrophic lateral sclerosis 3 9.9 DUSP11 ALS2
24 autosomal dominant cerebellar ataxia 9.8 VCP UBQLN2 SETX FUS
25 spinal muscular atrophy 9.8 VAPB SIGMAR1 SETX FUS
26 progressive bulbar palsy 9.8 VAPB SETX FUS ALS2
27 muscular atrophy 9.8 VAPB SIGMAR1 SETX FUS
28 charcot-marie-tooth disease, axonal, type 2e 9.8 VCP SPG11 FIG4 ALS2
29 giant axonal neuropathy 2 9.7 UBQLN2 OPTN FUS
30 amyotrophic lateral sclerosis type 5 9.7 VAPB SPG11 SETX ALS2
31 neuromuscular disease 9.7 VCP FUS FIG4
32 multisystem proteinopathy 9.6 VCP UBQLN2 OPTN FUS
33 aphasia 9.6 VCP OPTN FUS CHMP2B
34 amyotrophic lateral sclerosis 21 9.6 VAPB SETX FUS FIG4 ALS2
35 amyotrophic lateral sclerosis 7 9.6 VAPB SPG11 SETX CHMP2B ALS2
36 hereditary spastic paraplegia 9.6 VCP UBQLN2 SPG11 SETX ALS2
37 charcot-marie-tooth disease 9.5 VCP SPG11 SETX FIG4 ALS2
38 frontotemporal dementia 9.5 VCP UBQLN2 OPTN FUS CHMP2B
39 dystonia 9.5 SETX FUS CHMP2B ALS2
40 pick disease of brain 9.5 VCP UBQLN2 OPTN FUS CHMP2B
41 juvenile amyotrophic lateral sclerosis 9.4 SPG11 SIGMAR1 SETX FUS ALS2
42 alzheimer disease 7 9.4 VCP VAPB SIGMAR1 OPTN FUS
43 neuropathy 9.4 SPG11 SETX OPTN FIG4
44 spinocerebellar ataxia 2 9.3 VAPB UBQLN2 SPG11 SETX FUS ALS2
45 progressive muscular atrophy 9.3 VCP VAPB UBQLN2 OPTN FUS CHMP2B
46 spastic paraplegia 64, autosomal recessive 9.3 UBQLN2 SPG11 SIGMAR1 SETX FUS ALS2
47 amyotrophic lateral sclerosis 18 9.1 VAPB UBQLN2 SIGMAR1 SETX FUS FIG4
48 spinal muscular atrophy, distal, autosomal recessive, 4 9.1 UBQLN2 SPG11 SETX OPTN FUS ALS2
49 amyotrophic lateral sclerosis type 15 9.1 VAPB UBQLN2 SPG11 SIGMAR1 SETX FIG4
50 hemochromatosis, type 1 8.9 VAPB SPG11 SETX OPTN FUS FIG4

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis Type 14:



Diseases related to Amyotrophic Lateral Sclerosis Type 14

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis Type 14

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis Type 14

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis Type 14

Genetic Tests for Amyotrophic Lateral Sclerosis Type 14

Anatomical Context for Amyotrophic Lateral Sclerosis Type 14

Publications for Amyotrophic Lateral Sclerosis Type 14

Articles related to Amyotrophic Lateral Sclerosis Type 14:

# Title Authors PMID Year
1
Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia. 61
23138764 2013
2
Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains. 61
23056506 2012

Variations for Amyotrophic Lateral Sclerosis Type 14

Expression for Amyotrophic Lateral Sclerosis Type 14

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis Type 14.

Pathways for Amyotrophic Lateral Sclerosis Type 14

Pathways related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 VCP VAPB UBQLN2 SPG11 SIGMAR1 SETX

GO Terms for Amyotrophic Lateral Sclerosis Type 14

Cellular components related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.96 VCP VAPB UBQLN2 SPG11 SETX OPTN
2 nucleus GO:0005634 9.85 VCP UBQLN2 SPG11 SIGMAR1 SETX OPTN
3 growth cone GO:0030426 9.13 SIGMAR1 SETX ALS2
4 lipid droplet GO:0005811 8.8 VCP SIGMAR1 FIG4

Biological processes related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell death GO:0008219 9.16 OPTN ALS2
2 endosome organization GO:0007032 8.96 CHMP2B ALS2
3 autophagy GO:0006914 8.92 VCP UBQLN2 OPTN CHMP2B

Molecular functions related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 VCP UBQLN2 SIGMAR1 SETX OPTN FUS
2 polyubiquitin modification-dependent protein binding GO:0031593 8.8 VCP UBQLN2 OPTN

Sources for Amyotrophic Lateral Sclerosis Type 14

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....