Amyotrophic Lateral Sclerosis Type 14 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Amyotrophic Lateral Sclerosis Type 14

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis Type 14:

Name: Amyotrophic Lateral Sclerosis Type 14 ¹² ¹⁵

Amyotrophic Lateral Sclerosis 14 with or Without Frontotemporal Dementia ⁷⁴

Amyotrophic Lateral Sclerosis, with or Without Frontotemporal Dementia ¹²

Amyotrophic Lateral Sclerosis 14 ¹²

Als14 ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060205

UMLS ⁷⁴ C3151403

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Summaries for Amyotrophic Lateral Sclerosis Type 14

Disease Ontology : ¹² An amyotrophic lateral sclerosis that has material basis in mutation in the VCP gene on chromosome 9.

MalaCards based summary : Amyotrophic Lateral Sclerosis Type 14, also known as amyotrophic lateral sclerosis 14 with or without frontotemporal dementia, is related to amyotrophic lateral sclerosis 14 with or without frontotemporal dementia and bronchopneumonia. An important gene associated with Amyotrophic Lateral Sclerosis Type 14 is UBQLN2 (Ubiquilin 2), and among its related pathways/superpathways are TBC/RABGAPs and Mitophagy - animal. Affiliated tissues include bone.

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Related Diseases for Amyotrophic Lateral Sclerosis Type 14

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile	Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21	Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7	Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9	Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12	Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17	Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20	Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23	Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25	Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15	Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis Type 14 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)

#	Related Disease	Score	Top Affiliating Genes
1	amyotrophic lateral sclerosis 14 with or without frontotemporal dementia	12.0
2	bronchopneumonia	10.1	VAPA VAPB
3	amyotrophic lateral sclerosis 8	10.0	FAF1 VAPA VAPB
4	amyotrophic lateral sclerosis 11	10.0	FUS OPTN
5	amyotrophic lateral sclerosis 7	9.9	FUS OPTN
6	frontotemporal dementia and/or amyotrophic lateral sclerosis 1	9.9	FUS UBQLN2 VCP
7	amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	9.9	FUS OPTN
8	frontotemporal dementia	9.9	FUS UBQLN2 VCP
9	dementia	9.9	FUS UBQLN2 VCP
10	amyotrophic lateral sclerosis 9	9.8	FUS OPTN
11	paget's disease of bone	9.8	OPTN VCP
12	amyotrophic lateral sclerosis 21	9.6	FUS OPTN VAPB VCP
13	motor neuron disease	9.6	FUS OPTN VAPB VCP
14	lateral sclerosis	9.5	FUS OPTN UBQLN2 VAPB VCP
15	amyotrophic lateral sclerosis 1	9.2	FUS OPTN UBQLN2 VAPA VAPB VCP

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis Type 14:

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Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis Type 14

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Drugs & Therapeutics for Amyotrophic Lateral Sclerosis Type 14

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis Type 14

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Genetic Tests for Amyotrophic Lateral Sclerosis Type 14

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Anatomical Context for Amyotrophic Lateral Sclerosis Type 14

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis Type 14:

⁴²

Bone

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Publications for Amyotrophic Lateral Sclerosis Type 14

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Genes for Amyotrophic Lateral Sclerosis Type 14

Genes related to Amyotrophic Lateral Sclerosis Type 14 (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	UBQLN2	Ubiquilin 2	Protein Coding	16.69	DISEASES inferred ¹⁵
2	FAF1	Fas Associated Factor 1	Protein Coding	16.18	DISEASES inferred ¹⁵
3	VAPB	VAMP Associated Protein B And C	Protein Coding	15.85	DISEASES inferred ¹⁵
4	VCP	Valosin Containing Protein	Protein Coding	15.76	DISEASES inferred ¹⁵
5	VAPA	VAMP Associated Protein A	Protein Coding	15.43	DISEASES inferred ¹⁵
6	OPTN	Optineurin	Protein Coding	14.89	DISEASES inferred ¹⁵
7	FUS	FUS RNA Binding Protein	Protein Coding	14.31	DISEASES inferred ¹⁵
8	GET3	Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase	Protein Coding	6.8	DISEASES inferred ¹⁵
9	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	5.87	DISEASES inferred ¹⁵
10	GABARAPL1	GABA Type A Receptor Associated Protein Like 1	Protein Coding	5.7	DISEASES inferred ¹⁵

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Variations for Amyotrophic Lateral Sclerosis Type 14

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Expression for Amyotrophic Lateral Sclerosis Type 14

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis Type 14.

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Pathways for Amyotrophic Lateral Sclerosis Type 14

Pathways related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TBC/RABGAPs ⁶⁷	10.63	GABARAPL2 OPTN
2	Mitophagy - animal ³⁸	10.61	GABARAPL1 GABARAPL2 OPTN

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GO Terms for Amyotrophic Lateral Sclerosis Type 14

Cellular components related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic vesicle	GO:0031410	9.71	GABARAPL1 GABARAPL2 OPTN UBQLN2
2	Golgi membrane	GO:0000139	9.62	GABARAPL2 OPTN VAPA VAPB
3	autophagosome membrane	GO:0000421	9.37	GABARAPL1 GABARAPL2
4	perinuclear region of cytoplasm	GO:0048471	9.35	FAF1 FUS OPTN VAPA VCP
5	endoplasmic reticulum exit site	GO:0070971	9.26	VAPA VAPB
6	VCP-NPL4-UFD1 AAA ATPase complex	GO:0034098	9.16	FAF1 VCP
7	autophagosome	GO:0005776	8.92	GABARAPL1 GABARAPL2 OPTN UBQLN2

Biological processes related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	ER to Golgi vesicle-mediated transport	GO:0006888	9.61	VAPA VAPB VCP
2	ubiquitin-dependent ERAD pathway	GO:0030433	9.54	UBQLN2 VCP
3	autophagosome assembly	GO:0000045	9.52	GABARAPL1 GABARAPL2
4	sphingolipid biosynthetic process	GO:0030148	9.51	VAPA VAPB
5	macroautophagy	GO:0016236	9.5	GABARAPL1 GABARAPL2 VCP
6	endoplasmic reticulum unfolded protein response	GO:0030968	9.49	VAPB VCP
7	autophagy of mitochondrion	GO:0000422	9.48	GABARAPL1 GABARAPL2
8	endoplasmic reticulum organization	GO:0007029	9.46	VAPA VAPB
9	positive regulation of protein complex assembly	GO:0031334	9.4	FAF1 VCP
10	cellular response to nitrogen starvation	GO:0006995	9.37	GABARAPL1 GABARAPL2
11	cell death	GO:0008219	9.33	FAF1 OPTN VAPA
12	COPII-coated vesicle budding	GO:0090114	9.26	VAPA VAPB
13	autophagosome maturation	GO:0097352	9.13	GABARAPL1 GABARAPL2 VCP
14	autophagy	GO:0006914	9.02	GABARAPL1 GABARAPL2 OPTN UBQLN2 VCP

Molecular functions related to Amyotrophic Lateral Sclerosis Type 14 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein domain specific binding	GO:0019904	9.58	FAF1 VAPA VCP
2	microtubule binding	GO:0008017	9.54	GABARAPL2 VAPA VAPB
3	ubiquitin protein ligase binding	GO:0031625	9.46	FAF1 GABARAPL1 GABARAPL2 VCP
4	polyubiquitin modification-dependent protein binding	GO:0031593	9.32	OPTN VCP
5	GABA receptor binding	GO:0050811	9.26	GABARAPL1 GABARAPL2
6	beta-tubulin binding	GO:0048487	9.13	GABARAPL1 GABARAPL2 VAPB
7	FFAT motif binding	GO:0033149	8.62	VAPA VAPB

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Sources for Amyotrophic Lateral Sclerosis Type 14

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