MCID: AMY109
MIFTS: 16

Amyotrophic Lateral Sclerosis Type 22

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis Type 22

MalaCards integrated aliases for Amyotrophic Lateral Sclerosis Type 22:

Name: Amyotrophic Lateral Sclerosis Type 22 12 15
Amyotrohpic Lateral Sclerosis 22 with or Without Frontotemporal Dementia 12
Amyotrophic Lateral Sclerosis 22 12
Als 22 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060355

Summaries for Amyotrophic Lateral Sclerosis Type 22

Disease Ontology : 12 An amyotrophic lateral sclerosis that has material basis in mutation in the TUBA4A gene on chromosome 2q35.

MalaCards based summary : Amyotrophic Lateral Sclerosis Type 22, also known as amyotrohpic lateral sclerosis 22 with or without frontotemporal dementia, is related to amyotrophic lateral sclerosis 22 with or without frontotemporal dementia and gerstmann-straussler disease. An important gene associated with Amyotrophic Lateral Sclerosis Type 22 is PRPH (Peripherin), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain.

Related Diseases for Amyotrophic Lateral Sclerosis Type 22

Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 1 Amyotrophic Lateral Sclerosis 2, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic Lateral Sclerosis 21 Amyotrophic Lateral Sclerosis 3
Amyotrophic Lateral Sclerosis 7 Amyotrophic Lateral Sclerosis 8
Amyotrophic Lateral Sclerosis 9 Amyotrophic Lateral Sclerosis 11
Amyotrophic Lateral Sclerosis 12 Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 17 Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 23 Amyotrophic Lateral Sclerosis 24
Amyotrophic Lateral Sclerosis 25 Amyotrophic Lateral Sclerosis Type 5
Amyotrophic Lateral Sclerosis Type 6 Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15 Amyotrophic Lateral Sclerosis Type 22
Tardbp-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis Type 22 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 14, show less)
# Related Disease Score Top Affiliating Genes
1 amyotrophic lateral sclerosis 22 with or without frontotemporal dementia 13.0
2 gerstmann-straussler disease 9.8 PRPH MGRN1
3 amyotrophic lateral sclerosis type 15 9.8 UBQLN2 PRPH
4 amyotrophic lateral sclerosis type 14 9.7 UBQLN2 PRPH
5 amyotrophic lateral sclerosis 19 9.7 UBQLN2 PRPH
6 amyotrophic lateral sclerosis 18 9.7 UBQLN2 PRPH
7 amyotrophic lateral sclerosis 17 9.7 UBQLN2 PRPH
8 lateral sclerosis 9.5 UBQLN2 TUBA4A PRPH
9 amyotrophic lateral sclerosis 11 9.5 UBQLN2 SYNJ2
10 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.4 UBQLN2 TUBA4A
11 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 9.2 TAF15 SYNJ2 PRPH MGRN1
12 frontotemporal dementia and/or amyotrophic lateral sclerosis 4 9.1 TAF15 SYNJ2 PRPH MGRN1
13 frontotemporal dementia and/or amyotrophic lateral sclerosis 2 8.9 TUBA4A TAF15 SYNJ2 PRPH MGRN1
14 amyotrophic lateral sclerosis 1 7.9 UBQLN2 TUBA4A TAF15 SYNJ2 PRPH MGRN1

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis Type 22:



Diseases related to Amyotrophic Lateral Sclerosis Type 22

Symptoms & Phenotypes for Amyotrophic Lateral Sclerosis Type 22

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis Type 22

Search Clinical Trials , NIH Clinical Center for Amyotrophic Lateral Sclerosis Type 22

Genetic Tests for Amyotrophic Lateral Sclerosis Type 22

Anatomical Context for Amyotrophic Lateral Sclerosis Type 22

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis Type 22:

40
Brain

Publications for Amyotrophic Lateral Sclerosis Type 22

Articles related to Amyotrophic Lateral Sclerosis Type 22:

(showing 3, show less)
# Title Authors PMID Year
1
A plug-and-play brain-computer interface to operate commercial assistive technology. 61
23590556 2014
2
Cobalamin as a regulator of serum and cerebrospinal fluid levels of normal prions. 61
23146213 2013
3
Determination of cerebrospinal fluid and serum lead levels in patients with amyotrophic lateral sclerosis and other neurological diseases. 61
2599056 1989

Variations for Amyotrophic Lateral Sclerosis Type 22

Expression for Amyotrophic Lateral Sclerosis Type 22

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis Type 22.

Pathways for Amyotrophic Lateral Sclerosis Type 22

Pathways related to Amyotrophic Lateral Sclerosis Type 22 according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 TUBA4A PRPH

GO Terms for Amyotrophic Lateral Sclerosis Type 22

Sources for Amyotrophic Lateral Sclerosis Type 22

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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