MCID: AMY003
MIFTS: 30

Amyotrophic Neuralgia

Categories: Neuronal diseases

Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 15
Neuralgic Amyotrophy 12 55 73
Brachial Plexus Neuritis 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10383
ICD10 33 G54.5
ICD9CM 35 353.5
MeSH 44 D020968
SNOMED-CT 68 26609002 3548001

Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as neuralgic amyotrophy, is related to neuropathy and neuritis. An important gene associated with Amyotrophic Neuralgia is SEPT9 (Septin 9), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and spinal cord.

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 neuropathy 30.5 GJB1 PMP22 PRX
2 neuritis 30.4 PMP22 SEPT9
3 neuropathy, hereditary, with liability to pressure palsies 30.0 GJB1 KIF1B PMP22
4 brachial plexus neuropathy 29.7 DNAH17 KIF1B PMP22 SEC14L1 SEPT9
5 sensory peripheral neuropathy 29.6 GJB1 PMP22 PRX
6 parsonage turner syndrome 12.1
7 amyotrophy, hereditary neuralgic 11.3
8 brachial plexus neuritis 10.9
9 turner syndrome 10.5
10 viral infectious disease 10.4
11 arthritis 10.2
12 mononeuropathy 10.2
13 hepatitis 10.1
14 facioscapulohumeral muscular dystrophy 1 10.1
15 rheumatoid arthritis 10.1
16 osteoid osteoma 10.1
17 muscle hypertrophy 10.1
18 dengue virus 10.1
19 polyglucosan body myopathy 1 with or without immunodeficiency 10.1
20 dengue disease 10.1
21 infective endocarditis 10.1
22 endocarditis 10.1
23 tetanus 10.1
24 lyme disease 10.1
25 ehlers-danlos syndrome 10.1
26 polyradiculopathy 10.1
27 median neuropathy 10.1
28 herpes zoster 10.1
29 amyloidosis 10.1
30 muscular dystrophy 10.1
31 al amyloidosis 10.1
32 hashimoto encephalopathy 10.1
33 notalgia paresthetica 10.1
34 neuropathy - hereditary 10.1
35 cytomegalovirus infection 10.1
36 encephalopathy 10.1
37 cleft palate, isolated 10.0
38 endometriosis 10.0
39 vasculitis 10.0
40 hypersensitivity vasculitis 10.0
41 hepatitis b 9.9
42 hepatitis e 9.9
43 dysphagia 9.9
44 charcot-marie-tooth disease, demyelinating, type 1f 9.8 GJB1 PMP22
45 charcot-marie-tooth disease, x-linked dominant, 1 9.8 GJB1 PMP22
46 charcot-marie-tooth disease, axonal, type 2f 9.8 GJB1 KIF1B
47 hereditary motor and sensory neuropathy, type iic 9.7 GJB1 KIF1B
48 charcot-marie-tooth disease, axonal, type 2d 9.7 GJB1 KIF1B PMP22
49 charcot-marie-tooth disease, demyelinating, type 1c 9.7 GJB1 KIF1B PMP22
50 charcot-marie-tooth disease, demyelinating, type 1b 9.7 GJB1 KIF1B PMP22

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Neurotransmitter Agents Phase 4
3 Cholinergic Agents Phase 4
4 Acetylcholine Release Inhibitors Phase 4
5 Botulinum Toxins Phase 4
6
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
7 Analgesics Phase 2, Phase 3
8 Peripheral Nervous System Agents Phase 2, Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
10 Analgesics, Non-Narcotic Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 2, Phase 3
13 Cyclooxygenase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
4 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
5 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357 Not Applicable
6 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
7 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
8 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Enrolling by invitation NCT03441347 Not Applicable

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

MalaCards organs/tissues related to Amyotrophic Neuralgia:

41
Lung, Testes, Spinal Cord

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

(show top 50) (show all 221)
# Title Authors Year
1
Amyotrophic neuralgia of atypical presentation associated with exposure to a hepatitis B vaccine. ( 29789233 )
2018
2
Challenging Diagnosis and Inpatient Rehabilitation of Acute Bilateral Neuralgic Amyotrophy Possibly Attributed to Lyme Disease: A Case Report. ( 29277293 )
2018
3
Phrenic neuropathy and diaphragm dysfunction in neuralgic amyotrophy. ( 30054437 )
2018
4
Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study. ( 30019529 )
2018
5
Chronic Brachial Plexus Neuritis That Developed into Typical Neuralgic Amyotrophy and Positively Responded to Immunotherapy. ( 29269655 )
2018
6
Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection. ( 29547884 )
2018
7
Herpes zoster increased risk of neuralgic amyotrophy: a retrospective, population-based matched cohort study. ( 30397829 )
2018
8
Neuralgic amyotrophy in children. ( 29315708 )
2018
9
The distribution of neuralgic amyotrophy lesions is overwhelmingly extraplexal. ( 29624718 )
2018
10
Ultrasound of peripheral nerves in neuralgic amyotrophy. ( 30107038 )
2018
11
Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy. ( 28477674 )
2017
12
Neuralgic amyotrophy following high-dose melphalan and autologous peripheral blood stem cell transplantation for AL amyloidosis. ( 29269794 )
2017
13
Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy. ( 28768846 )
2017
14
Neuralgic amyotrophy triggered by hepatitis E virus: a particular phenotype. ( 28247042 )
2017
15
Neuralgic amyotrophy associated with hepatitis E virus (HEV) infection: a case report. ( 27095100 )
2017
16
Neuralgic amyotrophy. An update. ( 27263426 )
2017
17
Lesion distribution among 281 patients with sporadic neuralgic amyotrophy. ( 27680713 )
2017
18
Comment on neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. ( 27783420 )
2017
19
Chiropractic management of a geriatric patient with idiopathic neuralgic amyotrophy: a case report. ( 28413223 )
2017
20
Ultrasonography in neuralgic amyotrophy: Sensitivity, spectrum of findings, and clinical correlations. ( 28556181 )
2017
21
Focused high-resolution sonography of the suprascapular nerve: A simple surrogate marker for neuralgic amyotrophy? ( 28618294 )
2017
22
Diagnosing neuralgic amyotrophy: Choosing the right test at the right time. ( 28646486 )
2017
23
Neuralgic Amyotrophy Attributed Incorrectly to Block-Related Injury: Understanding Errors in Clinical Reasoning. ( 28665875 )
2017
24
Modeling of Lung Function Recovery in Neuralgic Amyotrophy With Diaphragm Impairment. ( 28698264 )
2017
25
Serial diaphragm ultrasound studies in neuralgic amyotrophy with bilateral phrenic neuropathies. ( 28722779 )
2017
26
Pediatric Hereditary Neuralgic Amyotrophy: Successful Treatment With Intravenous Immunoglobulin and Insights Into SEPT9 Pathogenesis. ( 28503616 )
2016
27
Neuralgic Amyotrophy Associated With Hepatitis E Virus Infection: First Case in the United States. ( 27861224 )
2016
28
Hepatitis E virus infection as a direct cause of neuralgic amyotrophy. ( 26939568 )
2016
29
Atypical initial manifestation of facioscapulohumeral muscular dystrophy mimicking neuralgic amyotrophy. ( 26755015 )
2016
30
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. ( 26662794 )
2016
31
Cerebrospinal fluid profile and seroprevalence of antiganglioside reactivity in patients with neuralgic amyotrophy. ( 26757215 )
2016
32
Unusual presentation of neuralgic amyotrophy with impairment of cranial nerve XII. ( 26788793 )
2016
33
Neuralgic amyotrophy mimicking Vernet syndrome. ( 26944154 )
2016
34
Neuroimaging of classic neuralgic amyotrophy. ( 27074430 )
2016
35
Electrodiagnostic studies for neuralgic amyotrophy. ( 27145205 )
2016
36
An early treated neuralgic amyotrophy with bilateral phrenic nerve involvement with a favorable outcome. ( 27147176 )
2016
37
Neuralgic amyotrophy is not the most common neurologic disorder of the shoulder: a 78-month prospective study of 60 neurologic shoulder patients in a specialist shoulder clinic. ( 27282731 )
2016
38
Poster 35 An Increased Incidence of Neuralgic Amyotrophy. ( 27672803 )
2016
39
Poster 153 Ultrasound Correlated Electrodiagnostic Diagnosis of Neuralgic Amyotrophy in a Collegiate Swimmer After Rapid Practice Intensity Change: A Case Report. ( 27672920 )
2016
40
Peripheral Nerve Ultrasound Imaging Shows Enlargement of Peripheral Nerves Outside the Brachial Plexus in Neuralgic Amyotrophy. ( 27749462 )
2016
41
Anterior interosseous nerve and posterior interosseous nerve involvement in neuralgic amyotrophy. ( 27821298 )
2016
42
Neuralgic Amyotrophy Manifesting as Mimicking Posterior Interosseous Nerve Palsy. ( 26713154 )
2015
43
Incidence of neuralgic amyotrophy (Parsonage Turner syndrome) in a primary care setting--a prospective cohort study. ( 26016482 )
2015
44
Ultrasonographic identification of nerve pathology in neuralgic amyotrophy: Enlargement, constriction, fascicular entwinement, and torsion. ( 25703205 )
2015
45
Neuralgic amyotrophy complicating acute hepatitis E infection: a rare association. ( 25739795 )
2015
46
Hepatitis-E virus associated neuralgic amyotrophy with sustained plexus brachialis swelling visualized by high-resolution ultrasound. ( 25769655 )
2015
47
Neuralgic amyotrophy associated with temporary vocal fold paralysis: successful treatment by vocal fold augmentation with hyaluronic acid. ( 25776098 )
2015
48
Hepatitis E and neuralgic amyotrophy: Five cases and review of literature. ( 26209399 )
2015
49
Spinal Cord Stimulation for Refractory Neuropathic Pain of Neuralgic Amyotrophy. ( 27169086 )
2015
50
Extended Neuralgic Amyotrophy Syndrome: voice therapy in one case of vocal fold paralysis. ( 24918513 )
2014

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

Pathways related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 GJB1 PMP22

GO Terms for Amyotrophic Neuralgia

Cellular components related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 8.8 DNAH17 KIF1B SEPT9

Biological processes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.62 DNAH17 KIF1B

Molecular functions related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.96 DNAH17 KIF1B
2 microtubule motor activity GO:0003777 8.62 DNAH17 KIF1B

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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