Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 15
Neuralgic Amyotrophy 12 55 73
Brachial Plexus Neuritis 44 73

Classifications:



Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as neuralgic amyotrophy, is related to brachial plexus neuritis and amyotrophy, hereditary neuralgic. An important gene associated with Amyotrophic Neuralgia is SEPT9 (Septin 9), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Related phenotypes are narrow mouth and cleft palate

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuritis 12.5
2 amyotrophy, hereditary neuralgic 11.1
3 hepatitis 10.0
4 hepatitis b 9.8
5 hepatitis e 9.8
6 dysphagia 9.8
7 charcot-marie-tooth disease, demyelinating, type 1c 9.7 KIF1B PMP22
8 charcot-marie-tooth neuropathy type 1 9.6 GJB1 PMP22
9 charcot-marie-tooth disease, demyelinating, type 1f 9.5 GJB1 PMP22
10 charcot-marie-tooth disease, axonal, type 2f 9.3 GJB1 KIF1B
11 hereditary motor and sensory neuropathy, type iic 9.1 GJB1 KIF1B
12 hereditary neuropathies 9.0 GJB1 PMP22 PRX
13 sensory peripheral neuropathy 9.0 GJB1 PMP22 PRX
14 charcot-marie-tooth disease, demyelinating, type 1b 9.0 GJB1 KIF1B PMP22
15 neuropathy, hereditary, with liability to pressure palsies 9.0 GJB1 KIF1B PMP22
16 peripheral nervous system disease 9.0 GJB1 PMP22
17 charcot-marie-tooth disease, axonal, type 2b 9.0 GJB1 KIF1B PMP22
18 motor peripheral neuropathy 9.0 GJB1 KIF1B PMP22
19 charcot-marie-tooth disease, demyelinating, type 1a 9.0 GJB1 KIF1B PMP22
20 charcot-marie-tooth disease, demyelinating, type 1d 8.9 GJB1 KIF1B PMP22
21 charcot-marie-tooth disease and deafness 8.9 GJB1 KIF1B PMP22
22 charcot-marie-tooth disease, axonal, type 2e 8.8 GJB1 KIF1B PMP22
23 neuropathy 8.7 GJB1 PMP22 PRX
24 hypertrophic neuropathy of dejerine-sottas 8.4 GJB1 KIF1B PMP22 PRX
25 neuropathy, congenital hypomyelinating or amyelinating, autosomal recessive 8.4 GJB1 KIF1B PMP22 PRX
26 tooth disease 8.4 GJB1 KIF1B PMP22 PRX
27 charcot-marie-tooth disease 8.2 GJB1 KIF1B PMP22 PRX
28 brachial plexus neuropathy 7.6 DNAH17 GJB1 KIF1B PMP22 SEC14L1 SEPT9

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

Human phenotypes related to Amyotrophic Neuralgia:

32 (show all 15)
# Description HPO Frequency HPO Source Accession
1 narrow mouth 32 occasional (7.5%) HP:0000160
2 cleft palate 32 occasional (7.5%) HP:0000175
3 round face 32 occasional (7.5%) HP:0000311
4 sprengel anomaly 32 frequent (33%) HP:0000912
5 acrocyanosis 32 occasional (7.5%) HP:0001063
6 polyneuropathy 32 hallmark (90%) HP:0001271
7 muscle weakness 32 hallmark (90%) HP:0001324
8 respiratory insufficiency 32 occasional (7.5%) HP:0002093
9 neurological speech impairment 32 occasional (7.5%) HP:0002167
10 sleep disturbance 32 occasional (7.5%) HP:0002360
11 arthralgia 32 hallmark (90%) HP:0002829
12 paresthesia 32 frequent (33%) HP:0003401
13 emg abnormality 32 hallmark (90%) HP:0003457
14 scapular winging 32 frequent (33%) HP:0003691
15 short stature 32 occasional (7.5%) HP:0004322

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Botulinum Toxins Phase 4
3 Cholinergic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
6 Analgesics Phase 2, Phase 3
7 Analgesics, Non-Narcotic Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11 Cyclooxygenase Inhibitors Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
4 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
5 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357 Not Applicable
6 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
7 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
8 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Enrolling by invitation NCT03441347 Not Applicable

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

(show top 50) (show all 67)
# Title Authors Year
1
Amyotrophic neuralgia of atypical presentation associated with exposure to a hepatitis B vaccine. ( 29789233 )
2018
2
Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy. ( 28477674 )
2017
3
Neuralgic amyotrophy following high-dose melphalan and autologous peripheral blood stem cell transplantation for AL amyloidosis. ( 29269794 )
2017
4
Chronic Brachial Plexus Neuritis that Developed into Typical Neuralgic Amyotrophy and Positively Responded to Immunotherapy. ( 29269655 )
2017
5
Neuralgic Amyotrophy Manifesting as Mimicking Posterior Interosseous Nerve Palsy. ( 26713154 )
2015
6
Incidence of neuralgic amyotrophy (Parsonage Turner syndrome) in a primary care setting--a prospective cohort study. ( 26016482 )
2015
7
Extended Neuralgic Amyotrophy Syndrome: voice therapy in one case of vocal fold paralysis. ( 24918513 )
2014
8
Neuralgic amyotrophy (Parsonage Turner syndrome). ( 24495384 )
2014
9
Neuralgic amyotrophy and hepatitis E virus infection. ( 24401685 )
2014
10
Neuralgic amyotrophy manifested by severe axillary mononeuropathy limited only to the anterior branch. ( 25418351 )
2014
11
Neonatal vocal cord paralysis-an early presentation of hereditary neuralgic amyotrophy due to a mutation in the SEPT9 gene. ( 22981636 )
2013
12
[Radial nerve palsy as a presenting feature of neuralgic amyotrophy]. ( 23603548 )
2013
13
Severe bilateral amyotrophic neuralgia associated with major dysphagia secondary to acute hepatitis E. ( 24555112 )
2013
14
Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. ( 24344182 )
2013
15
Neuralgic amyotrophy (Parsonage-Turner syndrome). ( 22751163 )
2012
16
Intravenous immunoglobulin (IVIg) with methylprednisolone pulse therapy for motor impairment of neuralgic amyotrophy: clinical observations in 10 cases. ( 22728480 )
2012
17
MRI findings and steroid therapy for neuralgic amyotrophy in children. ( 21824572 )
2011
18
Four cases of anti-ganglioside antibody-positive neuralgic amyotrophy with good response to intravenous immunoglobulin infusion therapy. ( 21872943 )
2011
19
Acute shoulder-girdle neuralgic amyotrophy (Parsonage-Turner syndrome with saphenous nerve involvement. ( 22368976 )
2011
20
Neuralgic amyotrophy: Parsonage-Turner Syndrome. ( 21035964 )
2010
21
Non-recurrent SEPT9 duplications cause hereditary neuralgic amyotrophy. ( 19939853 )
2010
22
Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation. ( 20019224 )
2010
23
Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy. ( 19139049 )
2009
24
SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy. ( 19451530 )
2009
25
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis). ( 19588414 )
2009
26
An atypical case of neuralgic amyotrophy with respiratory muscle weakness: case report and review of literature. ( 18422204 )
2008
27
Dysmorphic syndrome of hereditary neuralgic amyotrophy associated with a SEPT9 gene mutation -- a family study. ( 18492087 )
2008
28
Isolated spinal accessory mononeuropathy associated with neurogenic muscle hypertrophy: restricted neuralgic amyotrophy or stretch-palsy? A case report. ( 18295637 )
2008
29
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. ( 17546647 )
2007
30
A4V superoxide dismutase mutation in apparently sporadic ALS resembling neuralgic amyotrophy. ( 16546761 )
2006
31
Phrenic neuropathy due to neuralgic amyotrophy. ( 16717226 )
2006
32
[Case of 12-year-old boy with idiopathic recurrent neuralgic amyotrophy]. ( 16986739 )
2006
33
Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy. ( 16775374 )
2006
34
Mutations in SEPT9 cause hereditary neuralgic amyotrophy. ( 16186812 )
2005
35
Histology of hereditary neuralgic amyotrophy. ( 15716548 )
2005
36
Notalgia paresthetica following neuralgic amyotrophy: a case report. ( 15060814 )
2004
37
Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy. ( 15052627 )
2004
38
Evidence of a founder effect and refinement of the hereditary neuralgic amyotrophy (HNA) locus on 17q25 in American families. ( 11935323 )
2002
39
Neuralgic amyotrophy as a manifestation of infectious mononucleosis. ( 12532929 )
2002
40
Hereditary neuralgic amyotrophy. ( 11523561 )
2001
41
Evidence for genetic heterogeneity in hereditary neuralgic amyotrophy. ( 11245726 )
2001
42
Craniofacial and cutaneous findings expand the phenotype of hereditary neuralgic amyotrophy. ( 11739810 )
2001
43
Mutation analysis of 4 candidate genes for hereditary neuralgic amyotrophy (HNA). ( 11409865 )
2001
44
Hereditary Neuralgic Amyotrophy (HNA) is genetically heterogeneous. ( 11697522 )
2001
45
The natural history of hereditary neuralgic amyotrophy in the Dutch population: two distinct types? ( 10734003 )
2000
46
Diagnostic guidelines for hereditary neuralgic amyotrophy or heredofamilial neuritis with brachial plexus predilection. On behalf of the European CMT Consortium. ( 10996784 )
2000
47
Hereditary neuralgic amyotrophy: mutation analysis of candidate genes. ( 10586268 )
1999
48
Genetic refinement of the hereditary neuralgic amyotrophy (HNA) locus at chromosome 17q25. ( 10602368 )
1999
49
Neuralgic amyotrophy (Parsonage-Turner syndrome): an often misdiagnosed diagnosis. ( 10540541 )
1999
50
[Two cases of neuralgic amyotrophy]. ( 9868314 )
1998

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

Pathways related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 GJB1 PMP22

GO Terms for Amyotrophic Neuralgia

Cellular components related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axoneme GO:0005930 8.96 DNAH17 SEPT9
2 microtubule GO:0005874 8.8 DNAH17 KIF1B SEPT9

Biological processes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.62 DNAH17 KIF1B

Molecular functions related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule motor activity GO:0003777 8.96 DNAH17 KIF1B
2 motor activity GO:0003774 8.62 DNAH17 KIF1B

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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