MCID: AMY003
MIFTS: 34

Amyotrophic Neuralgia

Categories: Neuronal diseases

Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 15
Neuralgic Amyotrophy 12 56 74
Brachial Plexus Neuritis 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10383
ICD9CM 36 353.5
MeSH 45 D020968
SNOMED-CT 69 26609002 3548001
ICD10 34 G54.5

Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as neuralgic amyotrophy, is related to neuropathy and neuropathy, hereditary, with liability to pressure palsies. An important gene associated with Amyotrophic Neuralgia is SEC14L1 (SEC14 Like Lipid Binding 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and spinal cord, and related phenotype is Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation.

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 neuropathy 30.3 GJB1 PMP22 PRX
2 neuropathy, hereditary, with liability to pressure palsies 30.0 GJB1 KIF1B PMP22
3 brachial plexus neuropathy 29.9 DNAH17 KIF1B PMP22 SEC14L1
4 sensory peripheral neuropathy 29.3 GJB1 PMP22 PRX
5 parsonage turner syndrome 12.3
6 amyotrophy, hereditary neuralgic 11.3
7 brachial plexus neuritis 10.9
8 turner syndrome 10.5
9 neuritis 10.4
10 pfeiffer syndrome 10.3
11 arthritis 10.3
12 mononeuropathy 10.3
13 chickenpox 10.2
14 facioscapulohumeral muscular dystrophy 1 10.1
15 rheumatoid arthritis 10.1
16 osteoid osteoma 10.1
17 muscle hypertrophy 10.1
18 dengue virus 10.1
19 polyglucosan body myopathy 1 with or without immunodeficiency 10.1
20 dengue disease 10.1
21 infective endocarditis 10.1
22 endocarditis 10.1
23 tetanus 10.1
24 cauda equina syndrome 10.1
25 lyme disease 10.1
26 ehlers-danlos syndrome 10.1
27 polyradiculopathy 10.1
28 median neuropathy 10.1
29 herpes zoster 10.1
30 amyloidosis 10.1
31 muscular dystrophy 10.1
32 al amyloidosis 10.1
33 hashimoto encephalopathy 10.1
34 notalgia paresthetica 10.1
35 neuropathy - hereditary 10.1
36 cytomegalovirus infection 10.1
37 encephalopathy 10.1
38 hepatitis 10.1
39 cleft palate, isolated 10.0
40 endometriosis 10.0
41 vasculitis 10.0
42 hypersensitivity vasculitis 10.0
43 hepatitis b 10.0
44 hepatitis e 10.0
45 dysphagia 10.0
46 charcot-marie-tooth disease, demyelinating, type 1f 9.9 GJB1 PMP22
47 charcot-marie-tooth disease, axonal, type 2f 9.8 GJB1 KIF1B
48 charcot-marie-tooth disease, x-linked dominant, 1 9.8 GJB1 PMP22
49 charcot-marie-tooth disease, axonal, type 2d 9.7 GJB1 KIF1B PMP22
50 charcot-marie-tooth disease, demyelinating, type 1c 9.7 GJB1 KIF1B PMP22

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

GenomeRNAi Phenotypes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 KIF1B PMP22 SRSF2

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Botulinum Toxins Phase 4
3 Acetylcholine Release Inhibitors Phase 4
4 Cholinergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
7 Analgesics Phase 2, Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
9 Peripheral Nervous System Agents Phase 2, Phase 3
10 Analgesics, Non-Narcotic Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Cyclooxygenase Inhibitors Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
4 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
5 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357 Not Applicable
6 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
7 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
8 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Enrolling by invitation NCT03441347 Not Applicable

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

MalaCards organs/tissues related to Amyotrophic Neuralgia:

42
Lung, Testes, Spinal Cord

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

(show top 50) (show all 223)
# Title Authors Year
1
Nivolumab-Induced Neuralgic Amyotrophy with Hourglass-like Constriction of the Anterior Interosseous Nerve. ( 30809822 )
2019
2
Bilateral idiopathic neuralgic amyotrophy involving selective branches of peripheral nerves with a stepwise progression: A case report. ( 31083213 )
2019
3
Phrenic nerve palsy in patients with neuralgic amyotrophy: case series study. ( 31058474 )
2019
4
Ultrasound of peripheral nerves in neuralgic amyotrophy. ( 30107038 )
2019
5
Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study. ( 30019529 )
2019
6
Herpes zoster increased risk of neuralgic amyotrophy: a retrospective, population-based matched cohort study. ( 30397829 )
2019
7
Amyotrophic neuralgia of atypical presentation associated with exposure to a hepatitis B vaccine. ( 29789233 )
2018
8
Chronic Brachial Plexus Neuritis That Developed into Typical Neuralgic Amyotrophy and Positively Responded to Immunotherapy. ( 29269655 )
2018
9
Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection. ( 29547884 )
2018
10
Neuralgic amyotrophy following high-dose melphalan and autologous peripheral blood stem cell transplantation for AL amyloidosis. ( 29269794 )
2018
11
The distribution of neuralgic amyotrophy lesions is overwhelmingly extraplexal. ( 29624718 )
2018
12
Neuralgic amyotrophy in children. ( 29315708 )
2018
13
Phrenic neuropathy and diaphragm dysfunction in neuralgic amyotrophy. ( 30054437 )
2018
14
Challenging Diagnosis and Inpatient Rehabilitation of Acute Bilateral Neuralgic Amyotrophy Possibly Attributed to Lyme Disease: A Case Report. ( 29277293 )
2018
15
Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy. ( 28768846 )
2017
16
Neuralgic amyotrophy triggered by hepatitis E virus: a particular phenotype. ( 28247042 )
2017
17
Neuralgic amyotrophy. An update. ( 27263426 )
2017
18
Lesion distribution among 281 patients with sporadic neuralgic amyotrophy. ( 27680713 )
2017
19
Neuralgic Amyotrophy Attributed Incorrectly to Block-Related Injury: Understanding Errors in Clinical Reasoning. ( 28665875 )
2017
20
Serial diaphragm ultrasound studies in neuralgic amyotrophy with bilateral phrenic neuropathies. ( 28722779 )
2017
21
Modeling of Lung Function Recovery in Neuralgic Amyotrophy With Diaphragm Impairment. ( 28698264 )
2017
22
Diagnosing neuralgic amyotrophy: Choosing the right test at the right time. ( 28646486 )
2017
23
Focused high-resolution sonography of the suprascapular nerve: A simple surrogate marker for neuralgic amyotrophy? ( 28618294 )
2017
24
Ultrasonography in neuralgic amyotrophy: Sensitivity, spectrum of findings, and clinical correlations. ( 28556181 )
2017
25
Chiropractic management of a geriatric patient with idiopathic neuralgic amyotrophy: a case report. ( 28413223 )
2017
26
Comment on neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. ( 27783420 )
2017
27
Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy. ( 28477674 )
2017
28
Neuralgic amyotrophy associated with hepatitis E virus (HEV) infection: a case report. ( 27095100 )
2017
29
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. ( 26662794 )
2016
30
Cerebrospinal fluid profile and seroprevalence of antiganglioside reactivity in patients with neuralgic amyotrophy. ( 26757215 )
2016
31
Unusual presentation of neuralgic amyotrophy with impairment of cranial nerve XII. ( 26788793 )
2016
32
Neuralgic amyotrophy mimicking Vernet syndrome. ( 26944154 )
2016
33
Neuroimaging of classic neuralgic amyotrophy. ( 27074430 )
2016
34
Electrodiagnostic studies for neuralgic amyotrophy. ( 27145205 )
2016
35
An early treated neuralgic amyotrophy with bilateral phrenic nerve involvement with a favorable outcome. ( 27147176 )
2016
36
Neuralgic amyotrophy is not the most common neurologic disorder of the shoulder: a 78-month prospective study of 60 neurologic shoulder patients in a specialist shoulder clinic. ( 27282731 )
2016
37
Poster 35 An Increased Incidence of Neuralgic Amyotrophy. ( 27672803 )
2016
38
Poster 153 Ultrasound Correlated Electrodiagnostic Diagnosis of Neuralgic Amyotrophy in a Collegiate Swimmer After Rapid Practice Intensity Change: A Case Report. ( 27672920 )
2016
39
Anterior interosseous nerve and posterior interosseous nerve involvement in neuralgic amyotrophy. ( 27821298 )
2016
40
Peripheral Nerve Ultrasound Imaging Shows Enlargement of Peripheral Nerves Outside the Brachial Plexus in Neuralgic Amyotrophy. ( 27749462 )
2016
41
Pediatric Hereditary Neuralgic Amyotrophy: Successful Treatment With Intravenous Immunoglobulin and Insights Into SEPT9 Pathogenesis. ( 28503616 )
2016
42
Hepatitis E virus infection as a direct cause of neuralgic amyotrophy. ( 26939568 )
2016
43
Neuralgic Amyotrophy Associated With Hepatitis E Virus Infection: First Case in the United States. ( 27861224 )
2016
44
Atypical initial manifestation of facioscapulohumeral muscular dystrophy mimicking neuralgic amyotrophy. ( 26755015 )
2016
45
Ultrasonographic identification of nerve pathology in neuralgic amyotrophy: Enlargement, constriction, fascicular entwinement, and torsion. ( 25703205 )
2015
46
Neuralgic amyotrophy associated with temporary vocal fold paralysis: successful treatment by vocal fold augmentation with hyaluronic acid. ( 25776098 )
2015
47
Neuralgic Amyotrophy Manifesting as Mimicking Posterior Interosseous Nerve Palsy. ( 26713154 )
2015
48
Spinal Cord Stimulation for Refractory Neuropathic Pain of Neuralgic Amyotrophy. ( 27169086 )
2015
49
Incidence of neuralgic amyotrophy (Parsonage Turner syndrome) in a primary care setting--a prospective cohort study. ( 26016482 )
2015
50
Neuralgic amyotrophy manifested by severe axillary mononeuropathy limited only to the anterior branch. ( 25418351 )
2015

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

Pathways related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 GJB1 PMP22

GO Terms for Amyotrophic Neuralgia

Biological processes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.96 DNAH17 KIF1B
2 regulation of RNA splicing GO:0043484 8.62 PRX SRSF2

Molecular functions related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.96 DNAH17 KIF1B
2 microtubule motor activity GO:0003777 8.62 DNAH17 KIF1B

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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