MCID: AMY003
MIFTS: 35

Amyotrophic Neuralgia

Categories: Neuronal diseases

Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 15
Brachial Plexus Neuritis 43 71
Neuralgic Amyotrophy 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10383
ICD9CM 34 353.5
MeSH 43 D020968
SNOMED-CT 67 26609002
ICD10 32 G54.5
UMLS 71 C0221759 C1510479

Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as brachial plexus neuritis, is related to brachial plexus neuritis and plexopathy. An important gene associated with Amyotrophic Neuralgia is SEPTIN9 (Septin 9), and among its related pathways/superpathways are Shigellosis and Cytoskeleton remodeling_RalA regulation pathway. The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skeletal muscle and kidney.

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuritis 32.0 TMC8 SEPTIN9
2 plexopathy 31.2 SEPTIN9 PMP22 DCAF8
3 median neuropathy 30.7 PMP22 DCAF8
4 neuritis 30.6 SEPTIN9 PMP22 MPZ
5 mononeuropathy 30.5 PMP22 MPZ
6 hereditary neuropathies 30.4 PMP22 MPZ
7 neuropathy 29.5 SEPTIN9 PMP22 MPZ DCAF8
8 charcot-marie-tooth disease, demyelinating, type 1a 29.5 PMP22 MPZ
9 brachial plexus neuropathy 23.9 TMC8 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5
10 amyotrophy, hereditary neuralgic 11.8
11 neuropathy, hereditary, with liability to pressure palsies 10.6
12 hepatitis 10.5
13 cleft palate, isolated 10.4
14 osteomyelitis 10.4
15 polyneuropathy 10.4
16 muscular atrophy 10.4
17 radiculopathy 10.4
18 nervous system disease 10.4
19 febrile seizures, familial, 11 10.3 SEPTIN7 SEPTIN14
20 mononeuritis of upper limb and mononeuritis multiplex 10.3 PMP22 DCAF8
21 gonadal dysgenesis 10.3
22 turner syndrome 10.3
23 febrile seizures, familial, 1 10.3 SEPTIN14 SEPTIN1
24 cauda equina syndrome 10.3
25 lyme disease 10.3
26 guillain-barre syndrome 10.3
27 mononeuritis multiplex 10.3
28 polyradiculopathy 10.3
29 neuromuscular disease 10.3
30 poliomyelitis 10.3
31 lung disease 10.3
32 cytomegalovirus infection 10.3
33 encephalopathy 10.3
34 parsonage turner syndrome 10.3
35 febrile seizures, familial, 4 10.2 SEPTIN14 SEPTIN1
36 vasculitis 10.2
37 superficial mycosis 10.1 TMC8 DCAF8
38 amyotrophic lateral sclerosis 1 10.1
39 blepharophimosis, ptosis, and epicanthus inversus 10.1
40 carpal tunnel syndrome 10.1
41 epicanthus 10.1
42 facioscapulohumeral muscular dystrophy 1 10.1
43 rheumatoid arthritis 10.1
44 spondylosis, cervical 10.1
45 chromosome 2q35 duplication syndrome 10.1
46 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
47 osteoid osteoma 10.1
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
49 muscle hypertrophy 10.1
50 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Cholinergic Agents Phase 4
3 Neurotransmitter Agents Phase 4
4 Botulinum Toxins Phase 4
5
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
6 Analgesics, Non-Narcotic Phase 2, Phase 3
7 Cyclooxygenase Inhibitors Phase 2, Phase 3
8 Analgesics Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Anti-Inflammatory Agents Phase 2, Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Probe Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Unknown status NCT03397459
4 Longitudinal Experimental Study on ULNTT1 and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357
5 The GRANVIA®-C Cervical Disc Prosthesis to Treat Symptomatic Degenerative Disc Diseases Completed NCT01518582
6 Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group Completed NCT02596815
7 Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group Completed NCT02595294
8 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Enrolling by invitation NCT03441347

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

MalaCards organs/tissues related to Amyotrophic Neuralgia:

40
Spinal Cord, Skeletal Muscle, Kidney, Liver, Lung, Breast, Testes

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

(show top 50) (show all 463)
# Title Authors PMID Year
1
Hepatitis E: an expanding epidemic with a range of complications. 61
32251845 2020
2
Amyotrophic neuralgia of atypical presentation associated with exposure to a hepatitis B vaccine. 61
29789233 2020
3
Neuralgic amyotrophy: a paradigm shift in diagnosis and treatment. 61
32487526 2020
4
Altered sensorimotor representations after recovery from peripheral nerve damage in neuralgic amyotrophy. 61
32203744 2020
5
Mortality and morbidity of locally acquired hepatitis E in the national Scottish cohort: a multicentre retrospective study. 61
32285976 2020
6
Infraspinatus muscle palsy involving suprascapular nerve, brachial plexus or cervical roots related to inflammatory or mechanical causes: Experience of 114 cases. 61
32147283 2020
7
Backpack palsy and other brachial plexus neuropathies in the military population. 61
31925878 2020
8
Phrenic neuropathy water immersion dyspnea: Clinical findings and need for patient counseling. 61
31992683 2020
9
Four cases of pediatric neuralgic amyotrophy treated with immunotherapy: one-year follow-up and literature review. 61
32228355 2020
10
Neuralgic Amyotrophy Presenting with Multifocal Myonecrosis and Rhabdomyolysis. 61
32337110 2020
11
A case of painless neuralgic amyotrophy responsive to immunotherapy. 61
32189092 2020
12
Clinico-diagnostic features of neuralgic amyotrophy in childhood. 61
32140911 2020
13
Identification of a rare SEPT9 variant in a family with autosomal dominant Charcot-Marie-Tooth disease. 61
32122354 2020
14
Parsonage Turner syndrome caused by Staphylococcus aureus spondylodiscitis. 61
32060112 2020
15
Extrahepatic manifestations of hepatitis E virus: An overview. 61
31601068 2020
16
Neurologic complications of acute hepatitis E virus infection. 61
31806684 2020
17
Multiphasic presentation of neuralgic amyotrophy associated with hepatitis E virus infection. 61
31573093 2020
18
A rare presentation of neuralgic amyotrophy in a child and a review of recent literature. 61
31526173 2019
19
[Parsonage-Turner syndrome. Report of one case]. 61
32186643 2019
20
Update on classification, epidemiology, clinical phenotype and imaging of the nonsystemic vasculitic neuropathies. 61
31313704 2019
21
Suprascapular neuropathy: A review of 87 cases. 61
31294855 2019
22
Hourglass-like constriction neuropathy of the suprascapular nerve detected by high-resolution magnetic resonance neurography: report of three patients. 61
30747238 2019
23
Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies. 61
31405908 2019
24
Hepatitis E virus infections in patients with MS on oral disease-modifying treatment. 61
31454772 2019
25
Neuralgic Amyotrophy in a 66-year-old Hiker: a Case Report. 61
31762709 2019
26
Phrenic nerve palsy in patients with neuralgic amyotrophy: case series study. 61
31058474 2019
27
NA-CONTROL: a study protocol for a randomised controlled trial to compare specific outpatient rehabilitation that targets cerebral mechanisms through relearning motor control and uses self-management strategies to improve functional capability of the upper extremity, to usual care in patients with neuralgic amyotrophy. 61
31391076 2019
28
Reflections of patients and therapists on a multidisciplinary rehabilitation programme for persons with brachial plexus injuries. 61
29385821 2019
29
Nivolumab-induced neuralgic amyotrophy with hourglass-like constriction of the anterior interosseous nerve. 61
30809822 2019
30
Bilateral idiopathic neuralgic amyotrophy involving selective branches of peripheral nerves with a stepwise progression: A case report. 61
31083213 2019
31
Brachial Plexopathies: Update on Treatment. 61
31030283 2019
32
Herpes zoster increased risk of neuralgic amyotrophy: a retrospective, population-based matched cohort study. 61
30397829 2019
33
Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study. 61
30019529 2019
34
Neuralgic Amyotrophy with Cervical Root and Cranial Nerves Involvement in a Child. 61
31645878 2019
35
Use of Noninvasive Ventilation with Volume-Assured Pressure Support in Neuralgic Amyotrophy with Bilateral Diaphragmatic Paralysis. 61
31908687 2019
36
A rare cause of brachial plexopathy: hereditary neuralgic amyotrophy. 61
31619932 2019
37
Ultrasound of peripheral nerves in neuralgic amyotrophy. 61
30107038 2019
38
William Barnett Warrington (1869-1919). 61
31574512 2019
39
The Diagnostic Sensitivity for Ulnar Neuropathy at the Elbow Is Not Increased by Addition of Needle EMG of ADM and FDI When Nerve Conduction Studies Are Normal. 61
30915020 2019
40
Post-operative emergence of acute brachial neuritis following posterior cervical laminectomy with fusion: A case report and review of the literature. 61
31726257 2019
41
Brachial plexitis: an unusual presentation in sickle cell disease. 61
31723392 2019
42
A strange case of dyspnoea. 61
31384549 2019
43
Parsonage-Turner Syndrome as a Rare Extrahepatic Complication of Hepatitis E Infection. 61
31508389 2019
44
Reversible bilateral phrenic nerve paralysis. 61
31681533 2019
45
A Review of Copy Number Variants in Inherited Neuropathies. 61
30258273 2018
46
The distribution of neuralgic amyotrophy lesions is overwhelmingly extraplexal. 61
29624718 2018
47
Phrenic neuropathy and diaphragm dysfunction in neuralgic amyotrophy. 61
30054437 2018
48
Challenging Diagnosis and Inpatient Rehabilitation of Acute Bilateral Neuralgic Amyotrophy Possibly Attributed to Lyme Disease: A Case Report. 61
29277293 2018
49
Ultrasound of the Brachial Plexus. 61
29791960 2018
50
Unilateral winged scapula: Clinical and electrodiagnostic experience with 128 cases, with special attention to long thoracic nerve palsy. 61
29314072 2018

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

GO Terms for Amyotrophic Neuralgia

Cellular components related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.34 TMC8 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5
2 cytoskeleton GO:0005856 10.18 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
3 cell projection GO:0042995 10.08 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
4 cell division site GO:0032153 10.07 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
5 synapse GO:0045202 10 SEPTIN8 SEPTIN3 SEPTIN11 PMP22 MPZ
6 septin complex GO:0031105 9.97 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
7 cilium GO:0005929 9.95 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
8 midbody GO:0030496 9.89 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12 SEPTIN1
9 spindle GO:0005819 9.86 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12
10 synaptic vesicle GO:0008021 9.85 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN2 SEPTIN1
11 stress fiber GO:0001725 9.81 SEPTIN9 SEPTIN7 SEPTIN12 SEPTIN11
12 motile cilium GO:0031514 9.8 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
13 presynapse GO:0098793 9.78 SEPTIN8 SEPTIN6 SEPTIN3
14 cleavage furrow GO:0032154 9.78 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12
15 chromosome, centromeric region GO:0000775 9.77 SEPTIN7 SEPTIN6 SEPTIN2
16 microtubule cytoskeleton GO:0015630 9.77 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
17 kinetochore GO:0000776 9.76 SEPTIN7 SEPTIN6 SEPTIN2
18 axoneme GO:0005930 9.75 SEPTIN9 SEPTIN7 SEPTIN2
19 condensed chromosome kinetochore GO:0000777 9.74 SEPTIN7 SEPTIN6 SEPTIN2
20 sperm annulus GO:0097227 9.72 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
21 non-motile cilium GO:0097730 9.7 SEPTIN9 SEPTIN7 SEPTIN2
22 septin ring GO:0005940 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4

Biological processes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 10.03 SEPTIN9 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN3
2 cell differentiation GO:0030154 9.93 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12 PMP22
3 cell division GO:0051301 9.93 SEPTIN9 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN3
4 spermatogenesis GO:0007283 9.8 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
5 cytoskeleton-dependent cytokinesis GO:0061640 9.77 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
6 cilium assembly GO:0060271 9.67 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN11
7 regulation of exocytosis GO:0017157 9.62 SEPTIN5 SEPTIN4 SEPTIN2 SEPTIN1
8 cellular protein localization GO:0034613 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
9 positive regulation of non-motile cilium assembly GO:1902857 9.43 SEPTIN9 SEPTIN7

Molecular functions related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 TMC8 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5
2 nucleotide binding GO:0000166 10.07 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
3 molecular adaptor activity GO:0060090 9.97 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
4 identical protein binding GO:0042802 9.88 SEPTIN7 SEPTIN5 SEPTIN4 SEPTIN3 SEPTIN12 SEPTIN1
5 GTP binding GO:0005525 9.77 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
6 structural molecule activity GO:0005198 9.67 SEPTIN7 SEPTIN5 SEPTIN4 MPZ
7 GTPase activity GO:0003924 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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