MCID: ANR006
MIFTS: 29

Anaerobic Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Anaerobic Pneumonia

MalaCards integrated aliases for Anaerobic Pneumonia:

Name: Anaerobic Pneumonia 12 15
Pneumonia Due to Anaerobes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:873
ICD9CM 34 482.81
UMLS 71 C0375327

Summaries for Anaerobic Pneumonia

Disease Ontology : 12 An aspiration pneumonia caused by anaerobic bacteria like Bacteroides fragilis, Peptostreptococcus, anaerobic streptococci, Fusobacterium species (Fusobacterium nucleatum and Fusobacterium necrophoram). Lung abscess and empyema are diagnosed in this disease.

MalaCards based summary : Anaerobic Pneumonia, also known as pneumonia due to anaerobes, is related to pneumonia and physiological polycythemia. An important gene associated with Anaerobic Pneumonia is LYZ (Lysozyme), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Related phenotypes are hematopoietic system and immune system

Related Diseases for Anaerobic Pneumonia

Diseases related to Anaerobic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 pneumonia 28.5 TLR2 SERPINA1 MPO IL6 IL1B CCL5
2 physiological polycythemia 10.3 IL6 IL1B
3 periodontitis, chronic 10.3 IL6 IL1B
4 uremic pruritus 10.3 IL6 IL1B
5 indolent plasma cell myeloma 10.3 IL6 IL1B
6 back pain 10.3 IL6 IL1B
7 transient arthritis 10.3 IL6 IL1B
8 glomeruloid hemangioma 10.2 IL6 IL1B
9 suppurative periapical periodontitis 10.2 IL6 IL1B
10 bacterial conjunctivitis 10.2 IL6 IL1B
11 tracheitis 10.2 IL6 IL1B
12 carbuncle 10.2 IL6 IL1B
13 hypopyon 10.2 IL6 IL1B
14 eales disease 10.2 IL6 IL1B
15 tenosynovitis 10.2 IL6 IL1B
16 anthracosis 10.2 IL6 IL1B
17 lung abscess 10.2 IL6 IL1B
18 traumatic brain injury 10.2 IL6 IL1B
19 brain injury 10.2 IL6 IL1B
20 peptic esophagitis 10.2 IL6 IL1B
21 recurrent corneal erosion 10.2 IL6 IL1B
22 baritosis 10.2 MPO IL1B
23 gingival recession 10.2 IL6 IL1B
24 bursitis 10.2 IL6 IL1B
25 laryngitis 10.2 IL6 IL1B
26 asphyxia neonatorum 10.2 IL6 IL1B
27 neurosyphilis 10.2 TLR6 TLR2
28 vaginal discharge 10.2 IL6 IL1B
29 irritant dermatitis 10.2 IL6 IL1B
30 background diabetic retinopathy 10.2 IL6 IL1B
31 anca-associated vasculitis 10.2 SERPINA1 MPO
32 iridocyclitis 10.2 IL6 IL1B
33 chorioretinitis 10.2 IL6 IL1B
34 trichomoniasis 10.2 IL6 IL1B
35 bagassosis 10.2 IL6 IL1B
36 gastrointestinal tularemia 10.2 TLR6 TLR2
37 epididymis disease 10.2 IL6 IL1B
38 euthyroid sick syndrome 10.2 IL6 IL1B
39 congenital cytomegalovirus 10.2 TLR2 IL1B
40 orchitis 10.2 IL6 IL1B
41 glossitis 10.2 IL6 IL1B
42 tularemia 10.2 TLR2 IL1B
43 erysipelas 10.2 IL6 IL1B
44 tuberculous meningitis 10.2 TLR2 LYZ
45 funisitis 10.2 IL6 IL1B
46 tendinitis 10.2 IL6 IL1B
47 neutrophilic dermatosis, acute febrile 10.2 MPO IL1B
48 silo filler's disease 10.2 TLR2 IL1B
49 pneumonic tularemia 10.2 TLR2 IL1B
50 chondromalacia 10.2 MPO IL6

Graphical network of the top 20 diseases related to Anaerobic Pneumonia:



Diseases related to Anaerobic Pneumonia

Symptoms & Phenotypes for Anaerobic Pneumonia

MGI Mouse Phenotypes related to Anaerobic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CCL5 CD40 IL1B IL6 LYZ MPO
2 immune system MP:0005387 9.85 CCL5 CD40 IL1B IL6 LYZ MPO
3 neoplasm MP:0002006 9.35 IL1B IL6 LYZ SERPINE1 TLR2
4 renal/urinary system MP:0005367 9.1 CD40 IL6 LYZ SERPINE1 TLR2 TLR7

Drugs & Therapeutics for Anaerobic Pneumonia

Search Clinical Trials , NIH Clinical Center for Anaerobic Pneumonia

Genetic Tests for Anaerobic Pneumonia

Anatomical Context for Anaerobic Pneumonia

Publications for Anaerobic Pneumonia

Articles related to Anaerobic Pneumonia:

# Title Authors PMID Year
1
Anaerobic Necrotizing Pneumonia: Another Potential Life-threatening Complication of Vaping? 61
32132153 2020
2
Infected pneumatocele following anaerobic pneumonia in adult. 61
16491835 2005
3
Tension pneumopericardium caused by positive pressure ventilation complicating anaerobic pneumonia. 61
12735423 2003
4
[Anaerobic pneumonia]. 61
10088425 1999
5
[Anaerobic pneumonia]. 61
8151972 1994
6
Pneumonia. Patient profiles, choice of empiric therapy, and the place of third-generation cephalosporins. 61
1730186 1992
7
[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. 61
3765970 1986
8
Anaerobic infections and their therapy. 61
7450861 1980

Variations for Anaerobic Pneumonia

Expression for Anaerobic Pneumonia

Search GEO for disease gene expression data for Anaerobic Pneumonia.

Pathways for Anaerobic Pneumonia

Pathways related to Anaerobic Pneumonia according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TLR7 TLR6 TLR2 SERPINA1 MPO LYZ
2
Show member pathways
13.25 TLR7 TLR6 TLR2 IL6 IL1B CD40
3
Show member pathways
13.05 TLR7 TLR6 TLR2 IL1B CD40
4
Show member pathways
12.68 TLR7 TLR2 IL6 IL1B CD40 CCL5
5 12.66 TLR2 IL6 IL1B CCL5
6
Show member pathways
12.6 TLR6 TLR2 IL6 IL1B
7
Show member pathways
12.54 TLR7 TLR6 TLR2 SERPINE1 IL6 IL1B
8
Show member pathways
12.5 TLR7 TLR6 TLR2 IL6 IL1B CD40
9
Show member pathways
12.47 TLR7 TLR6 TLR2 IL1B CD40
10 12.25 TLR7 TLR6 TLR2 MPO IL1B CCL5
11
Show member pathways
12.21 SERPINE1 MPO IL6 IL1B CCL5
12
Show member pathways
12.16 TLR7 TLR6 TLR2 IL6
13
Show member pathways
12.13 TLR2 IL1B CD40
14 12.13 TLR6 TLR2 IL6 IL1B
15
Show member pathways
12.11 TLR7 TLR6 TLR2 SERPINE1 IL6 IL1B
16 12.1 IL6 IL1B CCL5
17 12.09 TLR7 TLR6 TLR2 IL6
18 12.01 TLR6 TLR2 MPO
19
Show member pathways
11.98 TLR7 TLR6 TLR2 IL6 IL1B
20
Show member pathways
11.94 TLR7 TLR6 TLR2 IL1B
21 11.87 IL6 IL1B CCL5
22 11.83 SERPINE1 IL6 IL1B
23 11.81 TLR2 IL6 IL1B
24 11.8 SERPINE1 IL6 IL1B
25 11.79 TLR2 IL6 IL1B CCL5
26 11.72 TLR7 TLR6 TLR2
27 11.66 TLR7 IL6 IL1B
28 11.6 TLR2 IL6 CD40
29 11.56 SERPINA1 IL6 IL1B CCL5
30 11.53 TLR2 IL6 IL1B
31
Show member pathways
11.51 TLR7 TLR6 TLR2 IL6 IL1B
32 11.46 IL6 IL1B CCL5
33 11.32 TLR2 IL6 IL1B CD40
34
Show member pathways
11.23 TLR7 TLR6 TLR2 IL6 IL1B
35 11.06 TLR2 IL1B
36 10.85 MPO IL1B
37 10.72 IL6 IL1B

GO Terms for Anaerobic Pneumonia

Cellular components related to Anaerobic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 SERPINE1 SERPINA1 MPO LYZ IL6 IL1B
2 extracellular space GO:0005615 9.23 SERPINE1 SERPINA1 MPO LYZ IL6 IL1B

Biological processes related to Anaerobic Pneumonia according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TLR6 TLR2 IL6 IL1B
2 neutrophil degranulation GO:0043312 9.97 TLR2 SERPINA1 MPO LYZ
3 response to lipopolysaccharide GO:0032496 9.85 TLR2 MPO IL1B
4 positive regulation of angiogenesis GO:0045766 9.84 SERPINE1 IL1B CD40
5 defense response to Gram-positive bacterium GO:0050830 9.81 TLR2 LYZ IL6
6 defense response to Gram-negative bacterium GO:0050829 9.81 SERPINE1 LYZ IL6
7 cellular response to lipopolysaccharide GO:0071222 9.81 SERPINE1 IL6 IL1B CD40
8 immune response GO:0006955 9.8 TLR7 TLR6 TLR2 IL6 IL1B CCL5
9 cellular response to mechanical stimulus GO:0071260 9.79 TLR7 IL1B CD40
10 regulation of insulin secretion GO:0050796 9.78 IL6 IL1B CCL5
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IL6 CD40 CCL5
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.76 TLR7 TLR2 IL1B
13 positive regulation of T cell proliferation GO:0042102 9.75 IL6 IL1B CCL5
14 toll-like receptor signaling pathway GO:0002224 9.73 TLR7 TLR6 TLR2
15 protein kinase B signaling GO:0043491 9.7 IL1B CD40 CCL5
16 negative regulation of neurogenesis GO:0050768 9.68 IL6 IL1B
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.68 TLR6 IL6
18 positive regulation of chemokine production GO:0032722 9.67 TLR7 TLR2 IL6
19 positive regulation of inflammatory response GO:0050729 9.67 TLR7 TLR2 SERPINE1 IL1B
20 positive regulation of monocyte chemotaxis GO:0090026 9.66 SERPINE1 CCL5
21 positive regulation of glial cell proliferation GO:0060252 9.65 IL6 IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.65 IL6 IL1B
23 I-kappaB phosphorylation GO:0007252 9.65 TLR7 TLR2
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TLR2 IL1B CCL5
25 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 TLR6 TLR2 IL6 IL1B CD40
26 cell activation GO:0001775 9.64 TLR6 TLR2
27 cellular response to bacterial lipopeptide GO:0071221 9.63 TLR6 TLR2
28 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.63 TLR7 TLR6 TLR2
29 regulation of cytokine secretion GO:0050707 9.62 TLR6 TLR2
30 vascular endothelial growth factor production GO:0010573 9.61 IL6 IL1B
31 cellular response to diacyl bacterial lipopeptide GO:0071726 9.59 TLR6 TLR2
32 microglial cell activation GO:0001774 9.58 TLR7 TLR6 TLR2
33 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.57 TLR6 TLR2
34 nitric oxide metabolic process GO:0046209 9.55 TLR6 TLR2
35 positive regulation of interleukin-6 production GO:0032755 9.55 TLR7 TLR6 TLR2 IL6 IL1B
36 response to bacterial lipoprotein GO:0032493 9.54 TLR6 TLR2
37 detection of diacyl bacterial lipopeptide GO:0042496 9.43 TLR6 TLR2
38 positive regulation of interleukin-8 production GO:0032757 9.35 TLR7 TLR2 SERPINE1 IL6 IL1B
39 inflammatory response GO:0006954 9.23 TLR7 TLR6 TLR2 LYZ IL6 IL1B

Molecular functions related to Anaerobic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR6 TLR2
2 NAD(P)+ nucleosidase activity GO:0050135 9.16 TLR6 TLR2
3 pattern recognition receptor activity GO:0038187 8.96 TLR7 TLR2
4 lipopeptide binding GO:0071723 8.62 TLR6 TLR2

Sources for Anaerobic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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