MCID: ANL014
MIFTS: 42

Anal Canal Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Anal Canal Adenocarcinoma

MalaCards integrated aliases for Anal Canal Adenocarcinoma:

Name: Anal Canal Adenocarcinoma 12 15 74
Adenocarcinoma of the Anal Canal 12 60
Adenocarcinoma of Anal Canal 12

Characteristics:

Orphanet epidemiological data:

60
adenocarcinoma of the anal canal
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:3692
NCIt 51 C7471
ICD10 via Orphanet 35 C21.1
Orphanet 60 ORPHA424016
UMLS 74 C1332259

Summaries for Anal Canal Adenocarcinoma

Disease Ontology : 12 An anal canal cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Anal Canal Adenocarcinoma, also known as adenocarcinoma of the anal canal, is related to appendix adenocarcinoma and rectum adenocarcinoma. An important gene associated with Anal Canal Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are MNAR-PELP1 and Estrogen Receptor Interaction and CD209 (DC-SIGN) signaling. Affiliated tissues include lung, thyroid and skin, and related phenotypes are anal canal adenocarcinoma and abdominal pain

Related Diseases for Anal Canal Adenocarcinoma

Diseases related to Anal Canal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.8 CDX2 KRT7
2 rectum adenocarcinoma 30.7 CDX2 KRT7
3 mucinous adenocarcinoma 30.7 CDX2 KRAS KRT7
4 adenocarcinoma 10.6
5 bile duct cystadenocarcinoma 10.5 KRT7 MUC5AC
6 malignant leydig cell tumor 10.5 KRT19 KRT7
7 bile duct mucoepidermoid carcinoma 10.5 KRT7 MUC5AC
8 corneal abscess 10.5 KRT19 KRT7
9 renal pelvis adenocarcinoma 10.5 KRT19 KRT7
10 renal pelvis carcinoma 10.5 KRT19 KRT7
11 bladder carcinoma in situ 10.5 KRT19 KRT7
12 jejunal adenocarcinoma 10.5 CDX2 KRT7
13 nasal cavity cancer 10.5 CDX2 KRT7
14 chronic cystitis 10.5 CDX2 KRT7
15 ovarian mucinous adenocarcinoma 10.5 CDX2 KRT7
16 thymus adenocarcinoma 10.5 CDX2 KRT7
17 epithelial predominant wilms' tumor 10.5 CDX2 KRT7
18 gastric diffuse adenocarcinoma 10.5 CDX2 KRT7
19 embryoma 10.5 CDX2 KRT19
20 prostate squamous cell carcinoma 10.4 HRAS KRT7
21 seminal vesicle tumor 10.4 KRT7 SYP
22 malignant struma ovarii 10.4 HRAS KRT19
23 medulloepithelioma 10.4 KRT7 SYP
24 panophthalmitis 10.4 MUC5AC SYP
25 glycogen-rich clear cell breast carcinoma 10.4 KRT7 SYP
26 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS KRAS
27 bile duct cysts 10.4 HRAS KRAS
28 periampullary adenoma 10.4 HRAS KRAS
29 secondary hypertrophic osteoarthropathy 10.4 HRAS KRAS
30 paronychia 10.4 HRAS KRAS
31 lung adenoid cystic carcinoma 10.4 HRAS KRAS
32 aggressive digital papillary adenocarcinoma 10.4 HRAS KRAS
33 intrahepatic bile duct adenoma 10.4 KRT19 KRT7
34 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
35 large intestine adenocarcinoma 10.4 KRT7 PIP
36 anterior cranial fossa meningioma 10.3 CHGA SYP
37 conventional angiosarcoma 10.3 CHGA SYP
38 nodular hidradenoma 10.3 KRT7 PIP
39 vulval paget's disease 10.3 KRT7 PIP
40 proliferating trichilemmal cyst 10.3 KRT19 KRT7
41 pancreatoblastoma 10.3 CHGA SYP
42 olfactory groove meningioma 10.3 CHGA SYP
43 chordoid meningioma 10.3 CHGA SYP
44 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
45 oncocytic breast carcinoma 10.3 KRT7 PIP
46 barrett esophagus 10.3 CDX2 KRT7 MUC5AC
47 mucinous intrahepatic cholangiocarcinoma 10.3 CDX2 MUC5AC
48 anal gland adenocarcinoma 10.3 KRT19 KRT7 MUC5AC
49 gastric signet ring cell adenocarcinoma 10.3 CDX2 PIP
50 lung oat cell carcinoma 10.3 CHGA ENO2

Graphical network of the top 20 diseases related to Anal Canal Adenocarcinoma:



Diseases related to Anal Canal Adenocarcinoma

Symptoms & Phenotypes for Anal Canal Adenocarcinoma

Human phenotypes related to Anal Canal Adenocarcinoma:

60 33 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anal canal adenocarcinoma 60 33 obligate (100%) Obligate (100%) HP:0030439
2 abdominal pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002027
3 lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0002716
4 intestinal bleeding 60 33 hallmark (90%) Very frequent (99-80%) HP:0002584
5 anal stenosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002025
6 chronic fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012432
7 neoplasm of the lung 60 33 frequent (33%) Frequent (79-30%) HP:0100526
8 neoplasm of the liver 60 33 frequent (33%) Frequent (79-30%) HP:0002896
9 neoplasm of the skeletal system 60 33 frequent (33%) Frequent (79-30%) HP:0010622
10 skin ulcer 60 33 occasional (7.5%) Occasional (29-5%) HP:0200042
11 rectal prolapse 60 33 occasional (7.5%) Occasional (29-5%) HP:0002035
12 neoplasm of the rectum 60 33 occasional (7.5%) Occasional (29-5%) HP:0100743

GenomeRNAi Phenotypes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 9.35 CDX2 ENO2 FOXP3 HRAS PIP
2 Reduced mammosphere formation GR00396-S 9.1 CHGA HRAS KRAS KRT7 MUC5AC TNFRSF1B

MGI Mouse Phenotypes related to Anal Canal Adenocarcinoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 CD274 ENO2 FOXP3 HRAS KRAS MUC5AC
2 cardiovascular system MP:0005385 10.13 CDX2 CHGA FOXP3 HRAS KRAS KRT19
3 cellular MP:0005384 10.11 CD274 CDX2 ENO2 FOXP3 KRAS KRT19
4 digestive/alimentary MP:0005381 10.09 CDX2 FOXP3 HRAS KRAS KRT19 MUC5AC
5 homeostasis/metabolism MP:0005376 10.07 CD274 CDX2 CHGA FOXP3 HRAS KRAS
6 endocrine/exocrine gland MP:0005379 10.06 CDX2 CHGA FOXP3 HRAS KRAS KRT19
7 integument MP:0010771 9.87 CD274 FOXP3 HRAS KRAS KRT19 SLC5A7
8 no phenotypic analysis MP:0003012 9.8 CD274 CHGA FOXP3 HRAS KRAS KRT19
9 normal MP:0002873 9.76 CDX2 FOXP3 HRAS KRAS KRT19 SLC5A7
10 renal/urinary system MP:0005367 9.43 CHGA FOXP3 HRAS KRAS KRT7 TNFRSF1B
11 respiratory system MP:0005388 9.1 ENO2 FOXP3 HRAS KRAS SLC5A7 TNFRSF1B

Drugs & Therapeutics for Anal Canal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Anal Canal Adenocarcinoma

Genetic Tests for Anal Canal Adenocarcinoma

Anatomical Context for Anal Canal Adenocarcinoma

MalaCards organs/tissues related to Anal Canal Adenocarcinoma:

42
Lung, Thyroid, Skin, Liver, Ovary, Breast, Thymus

Publications for Anal Canal Adenocarcinoma

Articles related to Anal Canal Adenocarcinoma:

(show all 23)
# Title Authors Year
1
Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report. ( 30458812 )
2018
2
Adenocarcinoma of the anal canal with an exceptional immunohistochemistry in a patient with serrated polyposis syndrome: a diagnostic challenge. ( 30168336 )
2018
3
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. ( 29700411 )
2018
4
Perianal Paget disease secondary to pagetoid spread of mucinous adenocarcinoma of the anal canal. ( 29400297 )
2018
5
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. ( 26728830 )
2016
6
Successful Treatment of Metastatic Anal Canal Adenocarcinoma with mFOLFOX6 + Bevacizumab. ( 27239180 )
2016
7
Anal Canal Adenocarcinoma in a Patient with Longstanding Crohn's Disease Arising From Rectal Mucosa that Migrated From a Previously Treated Rectovaginal Fistula. ( 27373845 )
2016
8
Adenocarcinoma of the anal canal: A report of two cases with review of literature. ( 27510691 )
2016
9
Metachronous adenocarcinoma of the anal canal after anterior resection for sporadic primary rectal adenocarcinoma: A rare case report. ( 25544486 )
2015
10
External sphincter resection for lower rectal and anal canal adenocarcinoma: achieving anal preservation with oncological and functional satisfaction. ( 24817058 )
2014
11
Precise endoscopic and pathologic features in a Crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinoma. ( 23411699 )
2013
12
Adenocarcinoma of the anal canal - a systematic review. ( 23809885 )
2013
13
Mucinous adenocarcinoma of the anal canal. ( 22643253 )
2012
14
Perianal Paget's disease happening with mucinous adenocarcinoma of the anal canal: managing rarities. ( 19702687 )
2010
15
Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. ( 19241106 )
2009
16
A twenty-year experience with adenocarcinoma of the anal canal. ( 19617747 )
2009
17
Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. ( 17384991 )
2007
18
Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. ( 24573877 )
2007
19
Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network. ( 12873671 )
2003
20
Perianal Paget's disease associated with anal canal adenocarcinoma and rectal villous adenoma. ( 9363457 )
1997
21
Anal canal adenocarcinoma. A report of 4 cases. ( 1763398 )
1991
22
Adenocarcinoma of the anal canal. ( 2398786 )
1990
23
Epidermoid carcinoma compared with adenocarcinoma of the anal canal. ( 6947779 )
1981

Variations for Anal Canal Adenocarcinoma

Expression for Anal Canal Adenocarcinoma

Search GEO for disease gene expression data for Anal Canal Adenocarcinoma.

Pathways for Anal Canal Adenocarcinoma

Pathways related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 HRAS KRAS
2 10.5 HRAS KRAS
3 10.26 HRAS KRAS
4 9.74 HRAS KRAS

GO Terms for Anal Canal Adenocarcinoma

Biological processes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 FOXP3 HRAS KRAS PIP
2 negative regulation of interleukin-10 production GO:0032693 9.32 CD274 FOXP3
3 negative regulation of activated T cell proliferation GO:0046007 9.26 CD274 FOXP3
4 response to isolation stress GO:0035900 9.16 HRAS KRAS
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 HRAS KRAS MUC5AC
6 regulation of long-term neuronal synaptic plasticity GO:0048169 8.8 HRAS KRAS SYP

Sources for Anal Canal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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