MCID: ANL014
MIFTS: 42

Anal Canal Adenocarcinoma

Categories: Gastrointestinal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Anal Canal Adenocarcinoma

MalaCards integrated aliases for Anal Canal Adenocarcinoma:

Name: Anal Canal Adenocarcinoma 12 15 73
Adenocarcinoma of the Anal Canal 12 59
Adenocarcinoma of Anal Canal 12

Characteristics:

Orphanet epidemiological data:

59
adenocarcinoma of the anal canal
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:3692
NCIt 50 C7471
Orphanet 59 ORPHA424016
ICD10 via Orphanet 34 C21.1
UMLS 73 C1332259

Summaries for Anal Canal Adenocarcinoma

Disease Ontology : 12 An anal canal cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Anal Canal Adenocarcinoma, also known as adenocarcinoma of the anal canal, is related to mucinous adenocarcinoma and villous adenoma. An important gene associated with Anal Canal Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Phospholipase D signaling pathway and BDNF-TrkB Signaling. Affiliated tissues include skin, lung and liver, and related phenotypes are anal canal adenocarcinoma and anal stenosis

Related Diseases for Anal Canal Adenocarcinoma

Diseases related to Anal Canal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 30.4 CDX2 KRAS KRT7
2 villous adenoma 30.4 CDX2 KRAS
3 intrahepatic bile duct adenoma 10.8 KRT19 KRT7
4 proliferating trichilemmal cyst 10.8 KRT19 KRT7
5 renal pelvis adenocarcinoma 10.8 KRT19 KRT7
6 cutaneous adenocystic carcinoma 10.8 KRT19 KRT7
7 eccrine adenocarcinoma 10.7 KRT19 KRT7
8 bladder carcinoma in situ 10.7 KRT19 KRT7
9 malignant leydig cell tumor 10.7 KRT19 KRT7
10 bile duct mucoepidermoid carcinoma 10.7 KRT7 MUC5AC
11 corneal abscess 10.7 KRT19 KRT7
12 bile duct cystadenocarcinoma 10.7 KRT7 MUC5AC
13 renal pelvis carcinoma 10.7 KRT19 KRT7
14 ovary neuroendocrine neoplasm 10.7 CDX2 KRT7
15 chondroid lipoma 10.7 KRT19 KRT7
16 vaginal benign neoplasm 10.7 CDX2 KRT7
17 appendix adenocarcinoma 10.7 CDX2 KRT7
18 vaginal adenoma 10.7 CDX2 KRT7
19 vaginal tubulovillous adenoma 10.7 CDX2 KRT7
20 mucinous adenofibroma 10.7 CDX2 KRT7
21 glandular cystitis 10.7 CDX2 KRT7
22 mucinous tubular and spindle renal cell carcinoma 10.7 KRT19 KRT7
23 mucinous bronchioloalveolar adenocarcinoma 10.6 CDX2 KRT7
24 epithelial predominant wilms' tumor 10.6 CDX2 KRT7
25 ovarian mucinous adenocarcinoma 10.6 CDX2 KRT7
26 mucinous intrahepatic cholangiocarcinoma 10.6 CDX2 MUC5AC
27 thymus adenocarcinoma 10.6 CDX2 KRT7
28 gastric diffuse adenocarcinoma 10.6 CDX2 KRT7
29 lipoadenoma 10.6 KRT19 KRT7
30 jejunal adenocarcinoma 10.6 CDX2 KRT7
31 chronic cystitis 10.6 CDX2 KRT7
32 immune system organ benign neoplasm 10.6 KRT19 KRT7
33 vulva adenocarcinoma 10.6 CDX2 KRT7
34 rectum adenocarcinoma 10.6 CDX2 KRT7
35 thymus lipoma 10.6 KRT19 KRT7
36 limbal stem cell deficiency 10.6 KRT19 MUC5AC
37 ampulla of vater adenocarcinoma 10.6 CDX2 KRT7
38 endocervical adenocarcinoma 10.5 CDX2 KRT7
39 pericardium cancer 10.5 KRT19 KRT7
40 cystic teratoma 10.5 CDX2 KRT7
41 malignant struma ovarii 10.5 HRAS KRT19
42 intraneural perineurioma 10.4 KRT19 KRT7
43 horseshoe kidney 10.4 CDX2 KRT7
44 anal gland adenocarcinoma 10.4 KRT19 KRT7 MUC5AC
45 adenocarcinoma 10.4
46 pancreatic cystadenocarcinoma 10.4 KRAS MUC5AC
47 prostate squamous cell carcinoma 10.4 HRAS KRT7
48 sigmoid neoplasm 10.4 HRAS KRAS
49 apocrine adenoma 10.4 HRAS KRAS
50 epithelial-myoepithelial carcinoma 10.3 HRAS KRT7

Graphical network of the top 20 diseases related to Anal Canal Adenocarcinoma:



Diseases related to Anal Canal Adenocarcinoma

Symptoms & Phenotypes for Anal Canal Adenocarcinoma

Human phenotypes related to Anal Canal Adenocarcinoma:

59 32 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anal canal adenocarcinoma 59 32 obligate (100%) Obligate (100%) HP:0030439
2 anal stenosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002025
3 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
4 intestinal bleeding 59 32 hallmark (90%) Very frequent (99-80%) HP:0002584
5 lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0002716
6 neoplasm of the liver 59 32 frequent (33%) Frequent (79-30%) HP:0002896
7 neoplasm of the skeletal system 59 32 frequent (33%) Frequent (79-30%) HP:0010622
8 chronic fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012432
9 neoplasm of the lung 59 32 frequent (33%) Frequent (79-30%) HP:0100526
10 rectal prolapse 59 32 occasional (7.5%) Occasional (29-5%) HP:0002035
11 neoplasm of the rectum 59 32 occasional (7.5%) Occasional (29-5%) HP:0100743
12 skin ulcer 59 32 occasional (7.5%) Occasional (29-5%) HP:0200042

GenomeRNAi Phenotypes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 HRAS KRAS KRT7 MUC5AC TNFRSF1B

MGI Mouse Phenotypes related to Anal Canal Adenocarcinoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 FOXP3 CD274 HRAS CDX2 KRAS SLC5A7
2 digestive/alimentary MP:0005381 10.1 FOXP3 KRT19 HRAS CDX2 KRAS TNFRSF1B
3 behavior/neurological MP:0005386 10.08 KRAS FOXP3 CD274 HRAS SLC5A7 TNFRSF1B
4 cardiovascular system MP:0005385 10.07 KRAS FOXP3 HRAS CDX2 SLC5A7 TNFRSF1B
5 cellular MP:0005384 10.05 CDX2 KRAS FOXP3 CD274 TNFRSF1B KRT19
6 endocrine/exocrine gland MP:0005379 10.02 KRAS FOXP3 HRAS CDX2 SLC5A7 TNFRSF1B
7 mortality/aging MP:0010768 10.01 KRAS FOXP3 CD274 HRAS CDX2 SLC5A7
8 integument MP:0010771 9.98 FOXP3 CD274 HRAS KRAS SLC5A7 TNFRSF1B
9 no phenotypic analysis MP:0003012 9.8 KRAS FOXP3 CD274 HRAS SLC5A7 KRT19
10 neoplasm MP:0002006 9.77 KRAS HRAS CDX2 TNFRSF1B KRT19
11 normal MP:0002873 9.73 KRAS FOXP3 HRAS CDX2 SLC5A7 KRT19
12 renal/urinary system MP:0005367 9.55 KRAS FOXP3 HRAS TNFRSF1B KRT7
13 respiratory system MP:0005388 9.35 KRAS FOXP3 HRAS SLC5A7 TNFRSF1B
14 skeleton MP:0005390 9.1 KRAS CD274 HRAS CDX2 TNFRSF1B KRT19

Drugs & Therapeutics for Anal Canal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Anal Canal Adenocarcinoma

Genetic Tests for Anal Canal Adenocarcinoma

Anatomical Context for Anal Canal Adenocarcinoma

MalaCards organs/tissues related to Anal Canal Adenocarcinoma:

41
Skin, Lung, Liver

Publications for Anal Canal Adenocarcinoma

Articles related to Anal Canal Adenocarcinoma:

(show all 12)
# Title Authors Year
1
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. ( 29700411 )
2018
2
Anal Canal Adenocarcinoma in a Patient with Longstanding Crohn's Disease Arising From Rectal Mucosa that Migrated From a Previously Treated Rectovaginal Fistula. ( 27373845 )
2016
3
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. ( 26728830 )
2016
4
Successful Treatment of Metastatic Anal Canal Adenocarcinoma with mFOLFOX6 + Bevacizumab. ( 27239180 )
2016
5
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. ( 26658388 )
2015
6
External sphincter resection for lower rectal and anal canal adenocarcinoma: achieving anal preservation with oncological and functional satisfaction. ( 24817058 )
2014
7
Precise endoscopic and pathologic features in a Crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinoma. ( 23411699 )
2013
8
Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. ( 24573877 )
2007
9
Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. ( 17384991 )
2007
10
Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network. ( 12873671 )
2003
11
Perianal Paget's disease associated with anal canal adenocarcinoma and rectal villous adenoma. ( 9363457 )
1997
12
Anal canal adenocarcinoma. A report of 4 cases. ( 1763398 )
1991

Variations for Anal Canal Adenocarcinoma

Expression for Anal Canal Adenocarcinoma

Search GEO for disease gene expression data for Anal Canal Adenocarcinoma.

Pathways for Anal Canal Adenocarcinoma

GO Terms for Anal Canal Adenocarcinoma

Biological processes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 HRAS KRAS MUC5AC
2 ERBB2 signaling pathway GO:0038128 9.4 HRAS KRAS
3 negative regulation of interferon-gamma production GO:0032689 9.37 CD274 FOXP3
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 HRAS KRAS
5 negative regulation of interleukin-10 production GO:0032693 9.16 CD274 FOXP3
6 negative regulation of activated T cell proliferation GO:0046007 8.96 CD274 FOXP3
7 response to isolation stress GO:0035900 8.62 HRAS KRAS

Sources for Anal Canal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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