MCID: ANL014
MIFTS: 44

Anal Canal Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Anal Canal Adenocarcinoma

MalaCards integrated aliases for Anal Canal Adenocarcinoma:

Name: Anal Canal Adenocarcinoma 12 15 73
Adenocarcinoma of the Anal Canal 12 59
Adenocarcinoma of Anal Canal 12

Characteristics:

Orphanet epidemiological data:

59
adenocarcinoma of the anal canal
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:3692
NCIt 50 C7471
Orphanet 59 ORPHA424016
ICD10 via Orphanet 34 C21.1
UMLS 73 C1332259

Summaries for Anal Canal Adenocarcinoma

Disease Ontology : 12 An anal canal cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Anal Canal Adenocarcinoma, also known as adenocarcinoma of the anal canal, is related to mucinous adenocarcinoma and villous adenoma. An important gene associated with Anal Canal Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Phospholipase D signaling pathway and BDNF-TrkB Signaling. Affiliated tissues include lung, liver and skin, and related phenotypes are abdominal pain and skin ulcer

Related Diseases for Anal Canal Adenocarcinoma

Diseases related to Anal Canal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 30.4 CDX2 KRAS KRT7
2 villous adenoma 30.2 CDX2 KRAS
3 adenocarcinoma 10.6
4 solid adenocarcinoma with mucin production 10.2 KRT7 MUC5AC
5 bile duct mucoepidermoid carcinoma 10.2 KRT7 MUC5AC
6 intrahepatic bile duct adenoma 10.2 KRT19 KRT7
7 proliferating trichilemmal cyst 10.2 KRT19 KRT7
8 bile duct cystadenocarcinoma 10.2 KRT7 MUC5AC
9 renal pelvis adenocarcinoma 10.2 KRT19 KRT7
10 cutaneous adenocystic carcinoma 10.2 KRT19 KRT7
11 bladder carcinoma in situ 10.2 KRT19 KRT7
12 malignant leydig cell tumor 10.2 KRT19 KRT7
13 corneal abscess 10.2 KRT19 KRT7
14 eccrine adenocarcinoma 10.2 KRT19 KRT7
15 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
16 chondroid lipoma 10.2 KRT19 KRT7
17 appendix adenocarcinoma 10.2 CDX2 KRT7
18 mucinous adenofibroma 10.2 CDX2 KRT7
19 glandular cystitis 10.2 CDX2 KRT7
20 renal pelvis carcinoma 10.2 KRT19 KRT7
21 mucinous intrahepatic cholangiocarcinoma 10.2 CDX2 MUC5AC
22 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
23 jejunal adenocarcinoma 10.2 CDX2 KRT7
24 mucinous tubular and spindle renal cell carcinoma 10.2 KRT19 KRT7
25 nasal cavity cancer 10.2 CDX2 KRT7
26 ovarian mucinous adenocarcinoma 10.2 CDX2 KRT7
27 thymus adenocarcinoma 10.2 CDX2 KRT7
28 gastric diffuse adenocarcinoma 10.2 CDX2 KRT7
29 chronic cystitis 10.2 CDX2 KRT7
30 vulva adenocarcinoma 10.2 CDX2 KRT7
31 lipoadenoma 10.2 KRT19 KRT7
32 thymus lipoma 10.2 KRT19 KRT7
33 rectum adenocarcinoma 10.2 CDX2 KRT7
34 limbal stem cell deficiency 10.2 KRT19 MUC5AC
35 mucinous bronchioloalveolar adenocarcinoma 10.2 CDX2 KRT7
36 pregnancy adenoma 10.2 KRT19 KRT7
37 ampulla of vater adenocarcinoma 10.2 CDX2 KRT7
38 immune system organ benign neoplasm 10.2 KRT19 KRT7
39 embryoma 10.2 CDX2 KRT19
40 endocervical adenocarcinoma 10.2 CDX2 KRT7
41 alveoli adenoma 10.2 KRAS KRT7
42 appendix cancer 10.2 CDX2 KRT7
43 prostatic acinar adenocarcinoma 10.2 CDX2 KRT7
44 pericardium cancer 10.2 KRT19 KRT7
45 cystic teratoma 10.1 CDX2 KRT7
46 prostate squamous cell carcinoma 10.1 HRAS KRT7
47 horseshoe kidney 10.1 CDX2 KRT7
48 crohn's disease 10.1
49 psoriasis 10.1
50 intraneural perineurioma 10.1 KRT19 KRT7

Graphical network of the top 20 diseases related to Anal Canal Adenocarcinoma:



Diseases related to Anal Canal Adenocarcinoma

Symptoms & Phenotypes for Anal Canal Adenocarcinoma

Human phenotypes related to Anal Canal Adenocarcinoma:

59 32 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
2 skin ulcer 59 32 occasional (7.5%) Occasional (29-5%) HP:0200042
3 chronic fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012432
4 rectal prolapse 59 32 occasional (7.5%) Occasional (29-5%) HP:0002035
5 neoplasm of the lung 59 32 frequent (33%) Frequent (79-30%) HP:0100526
6 neoplasm of the rectum 59 32 occasional (7.5%) Occasional (29-5%) HP:0100743
7 lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0002716
8 intestinal bleeding 59 32 hallmark (90%) Very frequent (99-80%) HP:0002584
9 anal stenosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002025
10 neoplasm of the liver 59 32 frequent (33%) Frequent (79-30%) HP:0002896
11 neoplasm of the skeletal system 59 32 frequent (33%) Frequent (79-30%) HP:0010622
12 anal canal adenocarcinoma 59 32 obligate (100%) Obligate (100%) HP:0030439

GenomeRNAi Phenotypes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 HRAS KRAS KRT7 MUC5AC TNFRSF1B

MGI Mouse Phenotypes related to Anal Canal Adenocarcinoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 CD274 CDX2 FOXP3 HRAS KRAS KRT7
2 digestive/alimentary MP:0005381 10.1 CDX2 FOXP3 HRAS KRAS KRT19 MUC5AC
3 behavior/neurological MP:0005386 10.08 CD274 FOXP3 HRAS KRAS MUC5AC SLC5A7
4 cardiovascular system MP:0005385 10.07 CDX2 FOXP3 HRAS KRAS KRT19 SLC5A7
5 cellular MP:0005384 10.05 CD274 CDX2 FOXP3 KRAS KRT19 KRT7
6 endocrine/exocrine gland MP:0005379 10.02 CDX2 FOXP3 HRAS KRAS KRT19 SLC5A7
7 mortality/aging MP:0010768 10.01 CD274 CDX2 FOXP3 HRAS KRAS KRT19
8 integument MP:0010771 9.98 CD274 FOXP3 HRAS KRAS KRT19 SLC5A7
9 no phenotypic analysis MP:0003012 9.8 CD274 FOXP3 HRAS KRAS KRT19 SLC5A7
10 normal MP:0002873 9.8 CDX2 FOXP3 HRAS KRAS KRT19 SLC5A7
11 neoplasm MP:0002006 9.77 CDX2 HRAS KRAS KRT19 TNFRSF1B
12 renal/urinary system MP:0005367 9.55 FOXP3 HRAS KRAS KRT7 TNFRSF1B
13 respiratory system MP:0005388 9.35 FOXP3 HRAS KRAS SLC5A7 TNFRSF1B
14 skeleton MP:0005390 9.1 CD274 CDX2 HRAS KRAS KRT19 TNFRSF1B

Drugs & Therapeutics for Anal Canal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Anal Canal Adenocarcinoma

Genetic Tests for Anal Canal Adenocarcinoma

Anatomical Context for Anal Canal Adenocarcinoma

MalaCards organs/tissues related to Anal Canal Adenocarcinoma:

41
Lung, Liver, Skin, Kidney, Ovary, Pancreas, Thymus

Publications for Anal Canal Adenocarcinoma

Articles related to Anal Canal Adenocarcinoma:

(show all 21)
# Title Authors Year
1
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. ( 29700411 )
2018
2
Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report. ( 30458812 )
2018
3
Adenocarcinoma of the anal canal with an exceptional immunohistochemistry in a patient with serrated polyposis syndrome: a diagnostic challenge. ( 30168336 )
2018
4
Anal Canal Adenocarcinoma in a Patient with Longstanding Crohn's Disease Arising From Rectal Mucosa that Migrated From a Previously Treated Rectovaginal Fistula. ( 27373845 )
2016
5
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. ( 26728830 )
2016
6
Successful Treatment of Metastatic Anal Canal Adenocarcinoma with mFOLFOX6 + Bevacizumab. ( 27239180 )
2016
7
Adenocarcinoma of the anal canal: A report of two cases with review of literature. ( 27510691 )
2016
8
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. ( 26658388 )
2015
9
Metachronous adenocarcinoma of the anal canal after anterior resection for sporadic primary rectal adenocarcinoma: A rare case report. ( 25544486 )
2015
10
External sphincter resection for lower rectal and anal canal adenocarcinoma: achieving anal preservation with oncological and functional satisfaction. ( 24817058 )
2014
11
Precise endoscopic and pathologic features in a Crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinoma. ( 23411699 )
2013
12
Adenocarcinoma of the anal canal - a systematic review. ( 23809885 )
2013
13
Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. ( 19241106 )
2009
14
A twenty-year experience with adenocarcinoma of the anal canal. ( 19617747 )
2009
15
Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. ( 24573877 )
2007
16
Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. ( 17384991 )
2007
17
Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network. ( 12873671 )
2003
18
Perianal Paget's disease associated with anal canal adenocarcinoma and rectal villous adenoma. ( 9363457 )
1997
19
Anal canal adenocarcinoma. A report of 4 cases. ( 1763398 )
1991
20
Adenocarcinoma of the anal canal. ( 2398786 )
1990
21
Epidermoid carcinoma compared with adenocarcinoma of the anal canal. ( 6947779 )
1981

Variations for Anal Canal Adenocarcinoma

Expression for Anal Canal Adenocarcinoma

Search GEO for disease gene expression data for Anal Canal Adenocarcinoma.

Pathways for Anal Canal Adenocarcinoma

GO Terms for Anal Canal Adenocarcinoma

Biological processes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of interferon-gamma production GO:0032689 9.37 CD274 FOXP3
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 HRAS KRAS
3 negative regulation of interleukin-10 production GO:0032693 9.26 CD274 FOXP3
4 negative regulation of activated T cell proliferation GO:0046007 9.16 CD274 FOXP3
5 response to isolation stress GO:0035900 8.96 HRAS KRAS
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 HRAS KRAS MUC5AC

Sources for Anal Canal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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