MCID: ANL014
MIFTS: 34

Anal Canal Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Anal Canal Adenocarcinoma

MalaCards integrated aliases for Anal Canal Adenocarcinoma:

Name: Anal Canal Adenocarcinoma 12 15 70
Adenocarcinoma of the Anal Canal 12 58
Adenocarcinoma of Anal Canal 12

Characteristics:

Orphanet epidemiological data:

58
adenocarcinoma of the anal canal
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:3692
NCIt 50 C7471
SNOMED-CT 67 764845008
ICD10 via Orphanet 33 C21.1
Orphanet 58 ORPHA424016
UMLS 70 C1332259

Summaries for Anal Canal Adenocarcinoma

Disease Ontology : 12 An anal canal cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Anal Canal Adenocarcinoma, also known as adenocarcinoma of the anal canal, is related to mammary paget's disease and anus adenocarcinoma. An important gene associated with Anal Canal Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include lung, colon and breast, and related phenotypes are anal canal adenocarcinoma and abdominal pain

Related Diseases for Anal Canal Adenocarcinoma

Diseases related to Anal Canal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 mammary paget's disease 30.0 PIP KRT7 KRT20
2 anus adenocarcinoma 29.9 MUC5AC KRT7 CDX2
3 adenocarcinoma 29.8 KRT7 KRT20 CEACAM5 CDX2
4 anal canal carcinoma 29.7 PIP KRT7 KRT20 CDX2
5 appendix adenocarcinoma 29.5 KRT7 KRT20 CDX2
6 adenoma 29.2 MUC5AC KRT7 KRT20 CDX2
7 paget disease, extramammary 29.2 PIP KRT7 KRT20 CEACAM5
8 rectum adenocarcinoma 28.9 PIP KRT7 KRT20 CEACAM5 CDX2
9 villous adenoma 28.8 MUC5AC KRT7 KRT20 CEACAM5 CDX2
10 mucinous adenocarcinoma 28.4 MUC5AC KRT7 KRT20 KRT19 CEACAM5 CDX2
11 adenofibroma 10.2 KRT7 KRT19
12 apocrine adenocarcinoma 10.2 PIP KRT7
13 proliferating trichilemmal cyst 10.2 KRT7 KRT19
14 ovarian cystadenoma 10.2 KRT7 CEACAM5
15 papillary adenoma 10.2 KRT7 CEACAM5
16 endobronchial lipoma 10.2 MUC5AC KRT7
17 solid adenocarcinoma with mucin production 10.2 MUC5AC KRT7
18 intrahepatic gall duct cancer 10.2 KRT7 KRT19
19 squamous cell bile duct carcinoma 10.2 KRT7 KRT19
20 lipoadenoma 10.2 KRT7 KRT19
21 pulmonary artery leiomyosarcoma 10.2 KRT7 KRT19
22 ovarian germ cell teratoma 10.2 KRT7 KRT19
23 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 KRT19
24 leukoplakia of penis 10.2 KRT7 CEACAM5
25 ceruminoma 10.2 PIP KRT7
26 mixed fibrolamellar hepatocellular carcinoma 10.2 KRT7 KRT19
27 oncocytic breast carcinoma 10.2 PIP KRT7
28 ceruminous adenocarcinoma 10.2 PIP KRT7
29 external ear carcinoma 10.2 KRT7 CEACAM5
30 uterus leiomyosarcoma 10.2 KRT7 KRT19
31 papillary squamous carcinoma 10.2 KRT7 CEACAM5
32 adenoid basal cell carcinoma 10.2 KRT7 CEACAM5
33 uterine corpus sarcoma 10.2 KRT7 KRT19
34 limbal stem cell deficiency 10.2 MUC5AC KRT19
35 breast mucinous carcinoma 10.2 PIP KRT7
36 crohn's disease 10.2
37 erysipeloid 10.1 PIP KRT7
38 liver sarcoma 10.1 KRT7 CEACAM5
39 suppurative thyroiditis 10.1 KRT7 KRT19
40 dacryocystocele 10.1 PIP KRT7
41 chronic inflammation of lacrimal passage 10.1 PIP KRT7
42 monophasic synovial sarcoma 10.1 KRT7 KRT19
43 tinea cruris 10.1 PIP KRT7
44 mediastinal cancer 10.1 KRT7 CEACAM5
45 keratinizing squamous cell carcinoma 10.1 KRT7 CEACAM5
46 ovary neuroendocrine neoplasm 10.1 KRT7 CDX2
47 cribriform carcinoma 10.1 PIP KRT7
48 adenosquamous colon carcinoma 10.1 KRT7 CDX2
49 acute cholangitis 10.1 MUC5AC CEACAM5
50 secretory meningioma 10.1 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Anal Canal Adenocarcinoma:



Diseases related to Anal Canal Adenocarcinoma

Symptoms & Phenotypes for Anal Canal Adenocarcinoma

Human phenotypes related to Anal Canal Adenocarcinoma:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anal canal adenocarcinoma 58 31 obligate (100%) Obligate (100%) HP:0030439
2 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
3 intestinal bleeding 58 31 hallmark (90%) Very frequent (99-80%) HP:0002584
4 anal stenosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002025
5 lymphadenopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0002716
6 chronic fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012432
7 neoplasm of the lung 58 31 frequent (33%) Frequent (79-30%) HP:0100526
8 neoplasm of the liver 58 31 frequent (33%) Frequent (79-30%) HP:0002896
9 neoplasm of the skeletal system 58 31 frequent (33%) Frequent (79-30%) HP:0010622
10 skin ulcer 58 31 occasional (7.5%) Occasional (29-5%) HP:0200042
11 rectal prolapse 58 31 occasional (7.5%) Occasional (29-5%) HP:0002035
12 neoplasm of the rectum 58 31 occasional (7.5%) Occasional (29-5%) HP:0100743

Drugs & Therapeutics for Anal Canal Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Anal Canal Adenocarcinoma

Genetic Tests for Anal Canal Adenocarcinoma

Anatomical Context for Anal Canal Adenocarcinoma

MalaCards organs/tissues related to Anal Canal Adenocarcinoma:

40
Lung, Colon, Breast, Liver, Thymus, Thyroid, Appendix

Publications for Anal Canal Adenocarcinoma

Articles related to Anal Canal Adenocarcinoma:

(show top 50) (show all 60)
# Title Authors PMID Year
1
Adverse Oncologic Outcomes of Adenocarcinoma of the Anal Canal in Patients With Crohn's Disease. 61
33394780 2021
2
Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report. 61
33316613 2021
3
Internal hemorrhoid harboring adenocarcinoma: A case report. 61
33510851 2021
4
Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management. 61
33049179 2020
5
Survival Outcomes After Initial Treatment for Anal Adenocarcinoma: A Population-Based Cohort Study. 61
32389595 2020
6
Anal canal adenocarcinoma with pagetoid spread and inguinal lymph node metastasis treated with preoperative chemoradiotherapy: A case report. 61
32337034 2020
7
Anorectal adenocarcinoma recurrence successfully treated with electrochemotherapy: a case report. 61
31567310 2020
8
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study. 61
32455011 2020
9
Long-term outcomes after surgical dissection of inguinal lymph node metastasis from rectal or anal canal adenocarcinoma. 61
31340778 2019
10
Rescue surgery for advanced anal gland adenocarcinoma: A case report. 61
31078011 2019
11
A CARE-compliant article: a case report of primary adenocarcinoma of the anal glands: Review of literature. 61
30608409 2019
12
[A Case of Anal Canal Adenocarcinoma Locally Controlled by Rectal Amputation after Chemoradiotherapy]. 61
30692388 2018
13
[Two Cases of Anal Canal Adenocarcinoma with Pagetoid Spread Treated with Laparoscopic Abdominoperineal Resection]. 61
30692326 2018
14
Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report. 61
30458812 2018
15
Adenocarcinoma of the anal canal with an exceptional immunohistochemistry in a patient with serrated polyposis syndrome: a diagnostic challenge. 61
30168336 2018
16
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. 61
29700411 2018
17
Perianal Paget disease secondary to pagetoid spread of mucinous adenocarcinoma of the anal canal. 61
29400297 2018
18
[A Case Report of Adenocarcinoma with Pagetoid Growth(Secondary Paget's Disease)of the Anal Canal]. 61
29394624 2017
19
Oxaliplatin-induced posterior reversible encephalopathy syndrome (PRES). 61
28978604 2017
20
Anal Neoplasia in Inflammatory Bowel Disease: Classification Proposal, Epidemiology, Carcinogenesis, and Risk Management Perspectives. 61
28379306 2017
21
Anal Canal Adenocarcinoma in a Patient with Longstanding Crohn's Disease Arising From Rectal Mucosa that Migrated From a Previously Treated Rectovaginal Fistula. 61
27373845 2016
22
Adenocarcinoma of the anal canal: A report of two cases with review of literature. 61
27510691 2016
23
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept. 61
26728830 2016
24
Successful Treatment of Metastatic Anal Canal Adenocarcinoma with mFOLFOX6 + Bevacizumab. 61
27239180 2016
25
[A Case of Anal Canal Cancer Treated by Abdominoperineal Resection in a 100-Year-Old Woman]. 61
26805352 2015
26
Metachronous adenocarcinoma of the anal canal after anterior resection for sporadic primary rectal adenocarcinoma: A rare case report. 61
25544486 2015
27
[A case of adenocarcinoma of the anal canal in which palliation was achieved by chemoradiotherapy]. 61
25731355 2014
28
External sphincter resection for lower rectal and anal canal adenocarcinoma: achieving anal preservation with oncological and functional satisfaction. 61
24817058 2014
29
Adenocarcinoma arising from an anal gland-Report of a case. 61
24705191 2014
30
Malignancies of the anal canal: a multi-center retrospective analysis in South China population. 61
24659650 2014
31
Adenocarcinoma of the anal canal - a systematic review. 61
23809885 2013
32
[Adenocarcinoma of the anal canal. Narrative review]. 61
23583090 2013
33
Precise endoscopic and pathologic features in a Crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinoma. 61
23411699 2013
34
Mucinous adenocarcinoma of the anal canal. 61
22643253 2012
35
[Preoperative chemoradiation (XELOX/RT) therapy for anal canal adenocarcinoma with the metastasis to inguinal lymph node]. 61
22202280 2011
36
[Extramammary Paget's disease as the form of presentation of anal canal adenocarcinoma]. 61
21481975 2011
37
Perianal Paget's disease happening with mucinous adenocarcinoma of the anal canal: managing rarities. 61
19702687 2010
38
A twenty-year experience with adenocarcinoma of the anal canal. 61
19617747 2009
39
Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. 61
19241106 2009
40
Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. 61
24573877 2007
41
Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. 61
17384991 2007
42
[Extramammary Paget's disease due to underlying anal canal adenocarcinoma]. 61
17374224 2006
43
[Clinical features and treatment of 49 patients with anal canal adenocarcinoma]. 61
17043960 2006
44
T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma. 61
16702164 2006
45
Anal canal carcinoma with Pagetoid spread: report of a case. 61
16794808 2006
46
Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network. 61
12873671 2003
47
Chemoradiation for adenocarcinoma of the anus. 61
12573754 2003
48
Perianal mucinous adenocarcinoma: unusual case presentations and review of the literature. 61
12641361 2003
49
Adenocarcinoma in the anal canal after ileal pouch-anal anastomosis for ulcerative colitis using a double stapling technique: report of a case. 61
12004221 2002
50
Adenocarcinoma below ileoanal anastomosis for ulcerative colitis: report of a case and review of the literature. 61
12068206 2002

Variations for Anal Canal Adenocarcinoma

Expression for Anal Canal Adenocarcinoma

Search GEO for disease gene expression data for Anal Canal Adenocarcinoma.

Pathways for Anal Canal Adenocarcinoma

Pathways related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT7 KRT20 KRT19
2
Show member pathways
11.25 KRT7 KRT20 KRT19

GO Terms for Anal Canal Adenocarcinoma

Cellular components related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 PIP MUC5AC KRT7 KRT19 CEACAM5
2 intermediate filament GO:0005882 8.8 KRT7 KRT20 KRT19

Biological processes related to Anal Canal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT7 KRT20 KRT19
2 cornification GO:0070268 8.8 KRT7 KRT20 KRT19

Sources for Anal Canal Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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