MCID: ANL008
MIFTS: 29

Anal Carcinoma in Situ

Categories: Cancer diseases

Aliases & Classifications for Anal Carcinoma in Situ

MalaCards integrated aliases for Anal Carcinoma in Situ:

Name: Anal Carcinoma in Situ 12 15
Carcinoma in Situ of Anal Canal 12 70
Carcinoma in Situ of Anus 12 70
Anal Intraepithelial Neoplasia Grade Iii 12
Anal Carcinoma Stage 0 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9087
ICD9CM 34 230.6
NCIt 50 C157575
SNOMED-CT 67 92537005
UMLS 70 C0154064 C2242854

Summaries for Anal Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the anus.

MalaCards based summary : Anal Carcinoma in Situ, also known as carcinoma in situ of anal canal, is related to in situ carcinoma and ulcerative stomatitis. An important gene associated with Anal Carcinoma in Situ is CD4 (CD4 Molecule), and among its related pathways/superpathways are Human cytomegalovirus infection and Immune response IL-23 signaling pathway. Affiliated tissues include anus, bone and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Anal Carcinoma in Situ

Diseases related to Anal Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.8 TP53 MYC
2 ulcerative stomatitis 10.1 TP53 CD4
3 penis squamous cell carcinoma 10.1 TP53 CD4
4 vaginal cancer 10.1 TP53 CD4
5 borst-jadassohn intraepidermal carcinoma 10.1 TP53 CD4
6 vulvar disease 10.1 TP53 CD4
7 papilledema 10.1 TP53 CD4
8 anus cancer 10.1 TP53 CD4
9 t-cell adult acute lymphocytic leukemia 10.1 TP53 CD4
10 anogenital venereal wart 10.1 TP53 CD4
11 fallopian tube disease 10.1 TP53 CD4
12 lichen disease 10.1 TP53 CD4
13 penile disease 10.1 TP53 CD4
14 vaginal disease 10.1 TP53 CD4
15 cheilitis 10.1 TP53 CD4
16 herpangina 10.1 TP53 CD4
17 anus disease 10.1 TP53 CD4
18 rectal disease 10.1 TP53 CD4
19 thymus gland disease 10.1 TP53 CD4
20 thymus cancer 10.1 TP53 CD4
21 salivary gland disease 10.1 TP53 CD4
22 testicular disease 10.0 TP53 CD4
23 epidermodysplasia verruciformis 1 10.0 TP53 CD4
24 pleural disease 10.0 TP53 CD4
25 pediatric liposarcoma 10.0 TP53 FUS
26 well-differentiated liposarcoma 10.0 TP53 FUS
27 diamond-blackfan anemia 1 10.0 TP53 CD4
28 myxofibrosarcoma 10.0 TP53 FUS
29 inclusion body myopathy with paget disease of bone and frontotemporal dementia 10.0 FUS CD4
30 dedifferentiated liposarcoma 10.0 TP53 FUS
31 bile duct disease 10.0 TP53 CD4
32 myxoid liposarcoma 10.0 TP53 FUS
33 frontal lobe neoplasm 9.9 TP53 MYC
34 b cell prolymphocytic leukemia 9.9 TP53 MYC
35 prolymphocytic leukemia 9.9 TP53 MYC
36 suppressor of tumorigenicity 3 9.9 TP53 MYC
37 gum cancer 9.9 TP53 MYC
38 megaesophagus 9.9 TP53 MYC
39 skin papilloma 9.9 TP53 MYC
40 supratentorial cancer 9.9 TP53 MYC
41 richter's syndrome 9.9 TP53 MYC
42 central nervous system hematologic cancer 9.9 MYC CD4
43 respiratory system benign neoplasm 9.9 TP53 MYC
44 lung adenoma 9.9 TP53 MYC
45 esophagus adenocarcinoma 9.9 TP53 MYC
46 rectum adenocarcinoma 9.9 TP53 MYC
47 ovarian cystadenocarcinoma 9.9 TP53 MYC
48 monoclonal gammopathy of uncertain significance 9.9 TP53 MYC
49 uterine corpus cancer 9.9 TP53 MYC
50 colonic benign neoplasm 9.9 TP53 MYC

Graphical network of the top 20 diseases related to Anal Carcinoma in Situ:



Diseases related to Anal Carcinoma in Situ

Symptoms & Phenotypes for Anal Carcinoma in Situ

GenomeRNAi Phenotypes related to Anal Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.1 FUS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-3 9.1 FUS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-57 9.1 FUS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.1 FUS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.1 FUS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.1 FUS

Drugs & Therapeutics for Anal Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Anal Carcinoma in Situ

Genetic Tests for Anal Carcinoma in Situ

Anatomical Context for Anal Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Anal Carcinoma in Situ:

19
Anus

MalaCards organs/tissues related to Anal Carcinoma in Situ:

40
Bone, Breast, Skin, Thymus, Ovary, Myeloid, Bone Marrow

Publications for Anal Carcinoma in Situ

Articles related to Anal Carcinoma in Situ:

# Title Authors PMID Year
1
Multiple low-grade sarcomas of fibroblastic type in the setting of HIV and acquired epidermodysplasia verruciformis. 61
23759878 2014
2
Changing patterns of anal canal carcinoma in the United States. 61
23509304 2013
3
Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ. 61
21744097 2011
4
Photodynamic therapy for carcinoma in situ of the anus. 61
15006881 2004
5
Risk of anal carcinoma in situ in relation to human papillomavirus type 16 variants. 61
9731493 1998
6
Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men. 61
8527551 1995

Variations for Anal Carcinoma in Situ

Expression for Anal Carcinoma in Situ

Search GEO for disease gene expression data for Anal Carcinoma in Situ.

Pathways for Anal Carcinoma in Situ

Pathways related to Anal Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 TP53 MYC CD4
2
Show member pathways
12.08 TP53 MYC CD4
3 11.71 TP53 MYC
4 11.7 TP53 MYC
5 11.67 TP53 MYC
6 11.66 TP53 MYC
7 11.64 TP53 MYC
8 11.56 TP53 MYC
9 11.53 TP53 MYC
10 11.48 TP53 MYC
11 11.47 TP53 MYC CD4
12 11.45 MYC CD4
13 11.41 TP53 MYC
14 11.38 TP53 MYC
15 11.34 TP53 MYC
16 11.22 TP53 MYC
17 11.19 TP53 MYC
18 11.14 TP53 MYC
19 11.1 TP53 MYC
20 11.08 TP53 MYC FUS
21 11.06 TP53 MYC
22 10.92 TP53 MYC
23 10.77 TP53 MYC
24
Show member pathways
10.6 TP53 MYC
25 10.5 TP53 MYC

GO Terms for Anal Carcinoma in Situ

Biological processes related to Anal Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 TP53 CD4
2 cellular response to drug GO:0035690 9.4 TP53 MYC
3 cellular response to UV GO:0034644 9.37 TP53 MYC
4 negative regulation of fibroblast proliferation GO:0048147 9.32 TP53 MYC
5 chromosome organization GO:0051276 9.26 TP53 MYC
6 response to gamma radiation GO:0010332 9.16 TP53 MYC
7 cytokine-mediated signaling pathway GO:0019221 9.13 TP53 MYC CD4
8 positive regulation of transcription, DNA-templated GO:0045893 8.92 TP53 MYC FUS CD4

Molecular functions related to Anal Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 core promoter sequence-specific DNA binding GO:0001046 8.62 TP53 MYC

Sources for Anal Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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