MCID: ANL022
MIFTS: 47

Anal Fistula

Categories: Gastrointestinal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Anal Fistula

MalaCards integrated aliases for Anal Fistula:

Name: Anal Fistula 12 59 15 38 33
Anorectal Fistula 72 33
Rectal Fistula 44 33

Characteristics:

Orphanet epidemiological data:

59
anal fistula
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Disease Ontology 12 DOID:0060328
MeSH 44 D012003
ICD10 via Orphanet 34 K60.3
UMLS via Orphanet 73 C0205929
Orphanet 59 ORPHA228113
UMLS 72 C0149889

Summaries for Anal Fistula

Disease Ontology : 12 An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.

MalaCards based summary : Anal Fistula, also known as anorectal fistula, is related to intestinal disease and colorectal adenocarcinoma. An important gene associated with Anal Fistula is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Adalimumab and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and colon, and related phenotype is neoplasm.

Wikipedia : 75 Anal fistula is a chronic abnormal communication between the epithelialised surface of the anal canal... more...

Related Diseases for Anal Fistula

Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 intestinal disease 30.0 MSH2 MLH1 DEFB4A
2 colorectal adenocarcinoma 29.8 MSH2 MLH1
3 colonic disease 29.7 MSH2 MLH1
4 ovarian cancer 28.6 MSH2 MMP9 MLH1 EGF
5 nijmegen breakage syndrome 11.3
6 crohn's disease 10.8
7 adenocarcinoma 10.4
8 folliculitis 10.4 EGF DEFB4A
9 inflammatory bowel disease 10.4
10 mucinous adenocarcinoma 10.3
11 appendix adenocarcinoma 10.3
12 rectum cancer 10.3
13 proctitis 10.3
14 hemorrhoid 10.3
15 sebaceous gland disease 10.3 MSH2 DEFB4A
16 hidradenitis suppurativa 10.2
17 hidradenitis 10.2
18 appendix carcinoid tumor 10.2 MSH2 MLH1
19 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MSH2 MLH1
20 adenosquamous colon carcinoma 10.2 MSH2 MLH1
21 lower lip cancer 10.2 MSH2 MLH1
22 pilonidal sinus 10.2
23 mycobacterium tuberculosis 1 10.2
24 crohn's colitis 10.2
25 pulmonary tuberculosis 10.2
26 47,xyy 10.2
27 melanocytic nevus syndrome, congenital 10.2 MSH2 MLH1
28 childhood kidney cell carcinoma 10.2 MSH2 MLH1
29 colorectal cancer, hereditary nonpolyposis, type 4 10.2 MSH2 MLH1
30 cecum adenocarcinoma 10.2 MSH2 MLH1
31 osteonecrosis of the jaw 10.2 DEFB4A DEFB103B
32 lynch syndrome i 10.2 MSH2 MLH1
33 sebaceous adenocarcinoma 10.2 MSH2 MLH1
34 intestinal benign neoplasm 10.2 MSH2 MLH1
35 gingivitis 10.1 MMP9 DEFB4A
36 keratoacanthoma 10.1 MSH2 MLH1
37 muir-torre syndrome 10.1 MSH2 MLH1
38 skin benign neoplasm 10.1 MSH2 MLH1
39 cheilitis 10.1 MSH2 MMP9
40 small intestine cancer 10.1 MSH2 MLH1
41 mismatch repair cancer syndrome 10.1 MSH2 MLH1
42 colorectal cancer, hereditary nonpolyposis, type 5 10.1 MSH2 MLH1
43 squamous cell carcinoma 10.1
44 constipation 10.1
45 familial colorectal cancer 10.0 MSH2 MLH1
46 cholesteatoma of middle ear 10.0 MMP9 EGF DEFB4A
47 colorectal adenoma 10.0 MSH2 MLH1
48 meningocele 10.0
49 anal canal carcinoma 10.0
50 langerhans cell histiocytosis 10.0

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to Anal Fistula

Symptoms & Phenotypes for Anal Fistula

MGI Mouse Phenotypes related to Anal Fistula:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP MLH1 MMP9 MSH2

Drugs & Therapeutics for Anal Fistula

Drugs for Anal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4 331731-18-1 16219006
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Prilocaine Approved Phase 4 721-50-6 4906
5 Anesthetics, General Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antirheumatic Agents Phase 4
8 Analgesics Phase 4
9 Cyclooxygenase Inhibitors Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Anesthetics, Intravenous Phase 4
13 Adjuvants, Anesthesia Phase 4
14 Analgesics, Opioid Phase 4
15 Adrenocorticotropic Hormone Phase 2, Phase 3
16 Melanocyte-Stimulating Hormones Phase 2, Phase 3
17 beta-endorphin Phase 2, Phase 3
18 Endorphins Phase 2, Phase 3
19 Hemostatics Phase 3
20 Fibrin Tissue Adhesive Phase 3
21 Coagulants Phase 3
22 Calamus Phase 2
23 Charcoal Phase 2
24 silver nitrate Approved, Investigational
25
Phenytoin Approved, Vet_approved 57-41-0 1775
26
Aminolevulinic acid Approved 106-60-5 137
27
Turmeric Approved, Experimental, Investigational
28
Clavulanate Approved, Vet_approved 58001-44-8 5280980
29
Amoxicillin Approved, Vet_approved 26787-78-0 33613
30
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
31
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
32
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
33
Povidone-iodine Approved 25655-41-8
34
Acetaminophen Approved 103-90-2 1983
35
Gabapentin Approved, Investigational 60142-96-3 3446
36
Ketamine Approved, Vet_approved 6740-88-1 3821
37
Ciprofloxacin Approved, Investigational 85721-33-1 2764
38
Acetylcysteine Approved, Investigational 616-91-1 12035
39
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
40
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
41
Clindamycin Approved, Vet_approved 18323-44-9 29029
42
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
43
Metronidazole Approved 443-48-1 4173
44
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
45 Cytochrome P-450 Enzyme Inducers
46 Adrenergic alpha-Antagonists
47 Adrenergic Antagonists
48 Adrenergic Agents
49 Androgens
50 Anti-Infective Agents, Local

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Unknown status NCT02423330 Phase 4
2 Double-blinded Multicenter Randomized Clinical Trial to Evaluate the Efficacy and Safety of CLIFE1 and CLIFE2 Gels in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
3 EUS Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
4 The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
5 Anal fistUla Repair With Platelet-Rich plasmA (AURoRA) Withdrawn NCT02678936 Phase 4
6 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
7 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair: a Multicenter, Randomized, Open-label, Parallel Controlled Trial Unknown status NCT01478139 Phase 3
8 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Unknown status NCT02336867 Phase 2, Phase 3
9 Multicentre,Randomized,Comparative,Add-on,Into Two Parallel Groups Clinical Trial to Evaluate Efficacy and Safety of Autologous Mesenchymal Stem Cells Derived From Expanded Adipose Tissue (ASC), for Treatment of Complex Perianal Fistulizing Disease in Patients Without IBD. Completed NCT01803347 Phase 3 ◦Drug: ASCs. + fibrin glue;fibrin glue
10 Seton Placement vs. Surgisis Anal Fistula Plug Insertion for Perirectal Fistula: A Prospective Randomized Study Completed NCT00450671 Phase 3
11 A Phase III Multicenter, Single Blind, Randomized, Comparative and add-on Clinical Trial, in Three Parallel Groups, to Evaluate Efficacy and Safety of a New Therapy With Adipose-derived Autologous Stem Cells for the Treatment of Complex Perianal Fistulas in Patients Without Inflammatory Bowel Disease Completed NCT00475410 Phase 3 ASCs (Cx401, company code);Fibrin adhesive
12 Adalimumab for the Treatment of Perianal Fistulas in Crohn's Disease More Effective Alone or Combined to Ciprofloxacin Completed NCT00736983 Phase 3 adalimumab;ciprofloxacin
13 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
14 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
15 Treatment of Perianal Fistulas in Crohn´s Disease Patients With Autologous Adipose Tissue Injection: A Randomized and Placebocontrolled Study Recruiting NCT03904212 Phase 2, Phase 3
16 A Phase 3, Multicenter, Open-Label, Uncontrolled Study to Evaluate the Efficacy and Safety of Cx601 in the Treatment of Complex Perianal Fistulas in Adult Patients With Crohn's Disease Recruiting NCT03706456 Phase 3
17 The Safety and Efficiacy of Local MSC Injection in the Treatment of Fistulas in Patients With Perianal Crohn's Disease Not yet recruiting NCT03056664 Phase 2, Phase 3
18 Randomized, Single-blind, Placebo Controlled Multicenter Phase III Study to Assess the Efficacy and Safety of Expanded Autologous Adipose-derived Stem Cells (ASCs) (CX-401), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease Terminated NCT01378390 Phase 3 Expanded autologous adipose-derived adult stem cells (eASCs);Placebo
19 Seton or Glue for Trans-sphincteric Anal Fistulas. A Prospective Randomised Clinical Trial Terminated NCT00929630 Phase 3
20 Phase II Clinical Trial, Multicentre, Randomised and Comparative, to Evaluate the Efficacy and Safety of a New Therapy With Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula Unknown status NCT00115466 Phase 2
21 A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas Unknown status NCT02456324 Phase 2
22 A Phase IIa Clinical Trial to Study the Treatment of the Extremely Complex and Conventional Treatment Resistant Perianal Fistulae With Autologous Stem Cells From Lipoaspirate Unknown status NCT01586715 Phase 2 Adipose-derived stem cells without expanded
23 Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study Unknown status NCT02403232 Phase 2
24 Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula Completed NCT01612195 Phase 2
25 An Open Prospective Study Evaluating the Efficacy and Safety of a Medical Device,KULIST, for the Treatment of Chronic, Non-complicated Perianal Fistulas Completed NCT01462747 Phase 2
26 Multicenter Phase I/IIa Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease. Completed NCT01372969 Phase 1, Phase 2 Cx601
27 Evaluation of Effectiveness and Safety of Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula Recruiting NCT03643614 Phase 1
28 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease: Pediatric Sub-study Recruiting NCT03449069 Phase 1 MSC-AFP
29 Re-treatment for Partial or Non-responders for a Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Perianal Fistulas Active, not recruiting NCT03209700 Phase 1 MSC-AFP
30 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With High, Transsphincteric Cryptoglandular Perianal Fistulas Active, not recruiting NCT02589119 Phase 1 MSC-AFP
31 An Outcome and Cost Analysis of Anal Fistula Plug Versus Endorectal Advancement Flap in Complex Anal Fistulae Unknown status NCT01931371
32 Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula: A Novel Strategy for Managing Anal Fistula Unknown status NCT01929525
33 A Multicenter Clinical Trial to Evaluate the Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula Unknown status NCT00951002
34 A Randomized, Prospective, Multi-Centered Study Comparing Clinical Outcomes of the Ligation of Intersphincteric Fistula Tract (LIFT)Procedure Versus Use of Anal Fistula Plug (AFP)in the Surgical Repair of Trans-Sphincteric Anal Fistulae of Cryptoglandular Origin Unknown status NCT00830661
35 Ligation of Intersphincteric Fistula Tract (LIFT) Versus Rectal Advanced Mucosal Flap (RAF) in Surgical Treatment of High Perianal Fistulas Unknown status NCT01997645
36 A Randomized Controlled Trial on the Effect of Topical Phenytoin 2% on Wound Healing After Fistulotomy Unknown status NCT03096522 Phenytoin 2% spray
37 A National, Multicenter, Randomized Open-Label Study of Proctological Surgery Efficacy on Anoperineal Fistulas Healing in Crohn's Disease Patients Treated With Adalimumab. (Official French Title: "Étude Nationale, Multicentrique, randomisée et en Ouvert de l'efficacité de la Chirurgie Proctologique Sur la Cicatrisation Des Fistules anopérinéales de la Maladie de Crohn Chez Des Patients traités Par Adalimumab") Unknown status NCT01388257
38 Use of Platelet Rich Plasma (PRP) as an Adjunct in the Treatment of High Peri-anal Fistulas. Unknown status NCT01615302
39 Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences Unknown status NCT02883296
40 Prospective Open-label Study of the Efficacy of the Addition of Hyperbaric Oxygen to the Treatment of Patients With Perianal Fistulas Already Treated With TNF Alpha Blockers Unknown status NCT01828190
41 Assessment of the Natural History and Treatment Outcomes for Patients With Fistula - a Pro- and Retrospective Cohort Study Unknown status NCT03003351
42 A Randomised Feasibility Trial to Investigate the Timing of HDR Brachytherapy With EBRT in Intermediate and High Risk Localised Prostate CAncer Patients and Its Effects on Toxicity and Quality of Life Unknown status NCT02618161
43 A Randomized Clinical Trial Comparing Surgisis AFP to Advancement Flap for the Repair of Anal Fistulas Completed NCT00545441
44 A Single-center Single Arm Prospective Study Evaluating the Surgisis Biodesign Anal Fistula Plug Completed NCT00703131
45 Ligation of the Intersphincteric Fistula Tract With Tissue Graft Placement for Treatment of Persistent Trans-sphincteric Anal Fistula Completed NCT01602081
46 Fistuolotomy With or Without Marsupialization for Treatment of Simple Anal Fistula: a Randomized Controlled Trial Completed NCT03595839
47 Drainage Seton Around the External Anal Sphincter With Mucosal Advancement Flap Versus External Anal Sphincter Preserving Seton in Treatment of Trans-sphincteric Anal Fistula Completed NCT03983174
48 A Retrospective Review of the Use of the Cook Biodesign® Fistula Plug (C-FPS-0.2, C-FPS-0.4, and C-FPS-0.7) to Treat Anorectal Fistulas Completed NCT03321266
49 Long-term Follow-up of Anal Fistula Plug for Treatment of Complex Trans-sphincteric Fistulas Completed NCT03961984
50 Efficacy of Photodynamic Therapy and Intra-lesional 5-wing in Complex Perianal Fistula Completed NCT03864718

Search NIH Clinical Center for Anal Fistula

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Anal Fistula cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: rectal fistula

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

MalaCards organs/tissues related to Anal Fistula:

41
Skin, Prostate, Colon, Bone, Small Intestine, Kidney, Bone Marrow

Publications for Anal Fistula

Articles related to Anal Fistula:

(show top 50) (show all 1196)
# Title Authors PMID Year
1
A rare case of rectal cancer with perianal metastasis: a case report. 38
31429762 2019
2
Anal fistula and pilonidal sinus disease coexisting simultaneously: An audit in a cohort of 1284 patients. 38
31412425 2019
3
Stereotactic Body Radiation Therapy Boost for Intermediate-Risk Prostate Cancer: A Phase 1 Dose-Escalation Study. 38
31002941 2019
4
One stage fistulectomy for high anal fistula with reconstruction of anal sphincter without fecal diversion. 38
30738718 2019
5
Risk Factors for Recurrence after anal fistula surgery: A meta-analysis. 38
31400504 2019
6
Efficacy of flap repair for anal fistula: study protocol for a systematic review of randomized controlled trial. 38
31415418 2019
7
Drainage Seton Versus External Anal Sphincter-Sparing Seton After Rerouting of the Fistula Tract in the Treatment of Complex Anal Fistula: A Randomized Controlled Trial. 38
31162376 2019
8
VAAFT assisted seton placement - video vignette. 38
31400250 2019
9
Sphincter-sparing surgery for complex anal fistulas: radiofrequency thermocoagulation of the tract is of no help. 38
30897291 2019
10
Injection of freshly collected autologous adipose tissue for treatment of a non-healing sacrococcygeal pilonidal disease patient - A video vignette. 38
31389100 2019
11
Successful Closure of a Rectal Fistula of Crohn's Disease Using Endoscopic Submucosal Dissection Combined With an Over-the-Scope Clip. 38
31397677 2019
12
Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula. 38
31320233 2019
13
A new understanding of the principles in the management of complex anal fistula. 38
31421428 2019
14
Contemporary surgical practice in the management of anal fistula: results from an international survey. 38
31368010 2019
15
Prevalence of anal fistula in the United Kingdom. 38
31417925 2019
16
Hemi-Gland Cryoablation for Localized Low-, Intermediate- and High-Risk Prostate Cancer: Oncologic and Functional Outcomes at 5 years. 38
31347953 2019
17
Platelet-rich plasma (PRP) versus fibrin glue in cryptogenic fistula-in-ano: a phase III single-center, randomized, double-blind trial. 38
31037566 2019
18
Ustekinumab for Crohn's disease: results of the ICC Registry, a nationwide prospective observational cohort study. 38
31219157 2019
19
A randomized controlled trial on the effect of topical phenytoin 2% on wound healing after anal fistulotomy. 38
30740877 2019
20
Fistulotomy with or without marsupialisation of wound edges in treatment of simple anal fistula: a randomised controlled trial. 38
31155896 2019
21
Anal fistula plug vs rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a systematic review and meta-analysis of studies with long-term follow-up. 38
30506546 2019
22
Can Perianal Fistula Be Treated Non-surgically with Platelet-Rich Fibrin Sealant? 38
30187327 2019
23
Antibiotic use in prevention of anal fistulas following incision and drainage of anorectal abscesses: A systematic review and meta-analysis. 38
30773213 2019
24
Feasibility of ambulatory surgery for anal fistula with LIFT procedure. 38
31146697 2019
25
Anal fistula plug versus surgeon's preference for surgery for trans-sphincteric anal fistula: the FIAT RCT. 38
31113531 2019
26
Endorectal advancement flap for complex anal fistula: does flap configuration matter? 38
30673146 2019
27
[An atypical presentation of a peri-anal fistula]. 38
31126868 2019
28
Extranodal natural killer/T-cell lymphoma (nasal type) presenting as a perianal abscess: A case report. 38
31119144 2019
29
Permacol Collagen Paste Injection for Treatment of Complex Cryptoglandular Anal Fistulas: An Observational Cohort Study With a 2-Year Follow-up. 38
30339103 2019
30
A mini-invasive procedure for the treatment of supralevator abscess of cryptoglandular origin by extrasphincteric extension: preliminary results at 1-year follow-up. 38
30645671 2019
31
[Application of closed negative pressure irrigation and suction device in the treatment of high perianal abscess]. 38
31054551 2019
32
[A Case of Primary Anal Fistula Cancer with Extensive Intrapelvic Spreading That Was Successfully Treated with Bevacizumab plus mFOLFOX6]. 38
31164514 2019
33
[Quality indicators in the treatment of anal fistulas]. 38
30683947 2019
34
Role of interleukin-17 in the pathogenesis of perianal abscess and anal fistula: a clinical study on 50 patients with perianal abscess. 38
30362208 2019
35
Factors Increasing the Risk of Recurrence in Fistula-in-ano. 38
31114719 2019
36
MRI T2-Weighted Imaging and Fat-Suppressed T2-Weighted Imaging Image Fusion Technology Improves Image Discriminability for the Evaluation of Anal Fistulas. 38
30799574 2019
37
Systematic review of the applications of three-dimensional printing in colorectal surgery. 38
30457180 2019
38
Correction to: Mucosal advancement flap for recurrent complex anal fistula: a repeatable procedure. 38
30570673 2019
39
Outcome of Modified Park's Technique for Treatment of Complex Anal Fistula. 38
30691840 2019
40
Anal Adenocarcinoma Can Masquerade as Chronic Anal Fistula in Asians. 38
30509019 2019
41
Permacol™ collagen paste for cryptoglandular and Crohn's anal fistula. 38
30758690 2019
42
Statement of the expert group on the current practice and prospects for the treatment of complex perirectal fistulas in the course of Crohn's disease. 38
30919811 2019
43
[Perianal abscess after anal intercourse should raise suspicion of rectal gonorrhoeae infection]. 38
30799811 2019
44
Long-Term Outcomes of Ligation of the Inter-Sphincteric Fistula Tract Plus Bioprosthetic Anal Fistula Plug (LIFT-Plug) in the Treatment of Trans-Sphincteric Perianal Fistula. 38
30783076 2019
45
OTSC® Proctology vs. fistulectomy and primary sphincter reconstruction as a treatment for low trans-sphincteric anal fistula in a randomized controlled pilot trial. 38
29397638 2019
46
International Conference "Anal Fistula" July 2-3, 2018 : A. Roma Lifestyle Hotel, Rome, Italy Conference Director: C. Ratto, Rome, Italy Local Scientific Committee: A. Parello, F. Litta, V. De Simone, U. Grossi. 38
30796619 2019
47
ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN'S DISEASE IN A SINGLE CENTER. 38
30758468 2019
48
[A Case of Rectal Cancer Presenting with Perianal Abscess]. 38
30765650 2019
49
[A case of Crohn's disease complicated by Guillain-Barrè syndrome during ustekinumab therapy]. 38
30971669 2019
50
Advancement flap procedure in Crohn and non-Crohn perineal fistulas: a simple surgical approach. 38
30199606 2019

Variations for Anal Fistula

Expression for Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for Anal Fistula

GO Terms for Anal Fistula

Cellular components related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 MMP9 EGF DEFB4A DEFB103B AFP
2 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 9.51 DEFB4A DEFB103B
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.49 MSH2 MLH1
3 positive chemotaxis GO:0050918 9.48 DEFB4A DEFB103B
4 killing of cells of other organism GO:0031640 9.46 DEFB4A DEFB103B
5 mismatch repair GO:0006298 9.43 MSH2 MLH1
6 positive regulation of DNA binding GO:0043388 9.4 MMP9 EGF
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MSH2 MLH1
8 isotype switching GO:0045190 9.32 MSH2 MLH1
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 MSH2 MLH1
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.26 DEFB4A DEFB103B
2 mismatched DNA binding GO:0030983 9.16 MSH2 MLH1
3 CCR6 chemokine receptor binding GO:0031731 8.96 DEFB4A DEFB103B
4 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Anal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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