Anal Fistula

Categories: Gastrointestinal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Anal Fistula

MalaCards integrated aliases for Anal Fistula:

Name: Anal Fistula 12 58 15 37 32
Anorectal Fistula 71 32
Rectal Fistula 43 32


Orphanet epidemiological data:

anal fistula
Prevalence: 1-5/10000 (Europe);


Orphanet: 58  
Rare gastroenterological diseases

External Ids:

Disease Ontology 12 DOID:0060328
MeSH 43 D012003
ICD10 via Orphanet 33 K60.3
UMLS via Orphanet 72 C0205929
Orphanet 58 ORPHA228113
UMLS 71 C0149889

Summaries for Anal Fistula

Disease Ontology : 12 An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.

MalaCards based summary : Anal Fistula, also known as anorectal fistula, is related to rectum cancer and adenocarcinoma. An important gene associated with Anal Fistula is DEFB103B (Defensin Beta 103B), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Direct p53 effectors. The drugs Adalimumab and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include Adipose.

Wikipedia : 74 Anal fistula is a chronic abnormal communication between the epithelialised surface of the anal canal... more...

Related Diseases for Anal Fistula

Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 rectum cancer 30.5 MSH2 MLH1 APOLD1
2 adenocarcinoma 30.5 MSH2 MMP9 MLH1 EGF
3 rectum adenocarcinoma 30.1 MSH2 MLH1 APOLD1
4 anal squamous cell carcinoma 30.0 MLH1 APOLD1
5 transitional cell carcinoma 29.9 MSH2 MMP9 MLH1
6 anorectal stricture 29.9 TNF APOLD1
7 colorectal adenocarcinoma 29.8 MSH2 MMP9 MLH1 EGF
8 tuberculous epididymitis 29.3 TNF AFP
9 hemorrhoid 29.1 TNF MMP9 MIR6086 MIR1185-1 APOLD1
10 nijmegen breakage syndrome 11.3
11 crohn's disease 10.8
12 osteonecrosis of the jaw 10.4 DEFB4A DEFB103B
13 inflammatory bowel disease 10.4
14 extrahepatic bile duct adenoma 10.3 MSH2 MLH1
15 renal pelvis transitional cell carcinoma 10.3 MSH2 MLH1
16 mucinous adenocarcinoma 10.3
17 appendix adenocarcinoma 10.3
18 adenosquamous colon carcinoma 10.3 MSH2 MLH1
19 appendix carcinoid tumor 10.3 MSH2 MLH1
20 familial colorectal cancer 10.3 MSH2 MLH1
21 jejunal cancer 10.3 MSH2 MLH1
22 colorectal cancer, hereditary nonpolyposis, type 6 10.3 MSH2 MLH1
23 lateral ventricle meningioma 10.3 MMP9 APOLD1
24 autosomal dominant non-syndromic intellectual disability 8 10.3 MSH2 MLH1
25 lower lip cancer 10.3 MSH2 MLH1
26 sebaceous gland neoplasm 10.3 MSH2 MLH1
27 colorectal cancer, hereditary nonpolyposis, type 5 10.3 MSH2 MLH1
28 internal hemorrhoid 10.3 MMP9 APOLD1
29 proctitis 10.3
30 endometrioid ovary carcinoma 10.3 MSH2 MLH1
31 duodenum adenocarcinoma 10.3 MSH2 MLH1
32 small intestine adenocarcinoma 10.3 MSH2 MLH1
33 crohn's colitis 10.2
34 hidradenitis suppurativa 10.2
35 hidradenitis 10.2
36 melanocytic nevus syndrome, congenital 10.2 MSH2 MLH1
37 pilonidal sinus 10.2
38 mycobacterium tuberculosis 1 10.2
39 pulmonary tuberculosis 10.2
40 47,xyy 10.2
41 dysplastic nevus syndrome 10.2 MSH2 MLH1
42 ductal carcinoma in situ 10.2 S100A7 MMP9 EGF
43 sebaceous adenoma 10.2 MSH2 MLH1 EGF
44 breast-ovarian cancer, familial 1 10.2 MSH2 MLH1
45 cholesteatoma of middle ear 10.2 MMP9 EGF DEFB4A
46 female reproductive endometrioid cancer 10.1 MSH2 MLH1
47 autoimmune inner ear disease 10.1 TNF MMP9
48 ascending colon cancer 10.1 MSH2 MLH1 APOLD1
49 central nervous system tuberculosis 10.1 TNF MMP9
50 duodenum cancer 10.1 MSH2 MLH1

Graphical network of the top 20 diseases related to Anal Fistula:

Diseases related to Anal Fistula

Symptoms & Phenotypes for Anal Fistula

Drugs & Therapeutics for Anal Fistula

Drugs for Anal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Adalimumab Approved Phase 4 331731-18-1 16219006
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Prilocaine Approved Phase 4 721-50-6 4906
Acetaminophen Approved Phase 4 103-90-2 1983
6 Sodium Channel Blockers Phase 4
7 Diuretics, Potassium Sparing Phase 4
8 Antirheumatic Agents Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Anti-Arrhythmia Agents Phase 4
12 Cyclooxygenase Inhibitors Phase 4
13 Analgesics Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Fibrin Tissue Adhesive Phase 3
16 Hemostatics Phase 3
17 Coagulants Phase 3
18 Calamus Phase 2
19 Anesthetics, General Phase 2
20 Charcoal Phase 2
silver nitrate Approved, Investigational 7761-88-8
Phenytoin Approved, Vet_approved 57-41-0 1775
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
Aminolevulinic acid Approved 106-60-5 137
Turmeric Approved, Experimental, Investigational
Clavulanate Approved, Vet_approved 58001-44-8 5280980
Amoxicillin Approved, Vet_approved 26787-78-0 33613
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
Povidone-iodine Approved 25655-41-8
Ketamine Approved, Vet_approved 6740-88-1 3821
Gabapentin Approved, Investigational 60142-96-3 3446
Ciprofloxacin Approved, Investigational 85721-33-1 2764
Acetylcysteine Approved, Investigational 616-91-1 12035
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
Clindamycin Approved, Vet_approved 18323-44-9 29029
Metronidazole Approved 443-48-1 4173
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
40 Adrenergic alpha-Antagonists
41 Androgens
42 Anticonvulsants
43 Anti-Infective Agents, Local
44 Turmeric extract
45 Amoxicillin-Potassium Clavulanate Combination
46 beta-Lactamase Inhibitors
47 Retinol palmitate
48 retinol
49 abobotulinumtoxinA
50 Botulinum Toxins

Interventional clinical trials:

(show top 50) (show all 112)
# Name Status NCT ID Phase Drugs
1 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Unknown status NCT02423330 Phase 4
2 EUS Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
3 Double-blinded Multicenter Randomized Clinical Trial to Evaluate the Efficacy and Safety of CLIFE1 and CLIFE2 Gels in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
4 The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
5 Peri-anal Local Anaesthetic Infiltration Versus Caudal Anaesthesia for Post-operative Pain Relief in Trans-anal Pull Through Operation for Hirschsprung's Disease. Not yet recruiting NCT04367818 Phase 4
6 Anal fistUla Repair With Platelet-Rich plasmA (AURoRA) Withdrawn NCT02678936 Phase 4
7 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
8 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair: a Multicenter, Randomized, Open-label, Parallel Controlled Trial Unknown status NCT01478139 Phase 3
9 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Unknown status NCT02336867 Phase 2, Phase 3
10 The Safety and Efficiacy of Local MSC Injection in the Treatment of Fistulas in Patients With Perianal Crohn's Disease Unknown status NCT03056664 Phase 2, Phase 3
11 Multicentre,Randomized,Comparative,Add-on,Into Two Parallel Groups Clinical Trial to Evaluate Efficacy and Safety of Autologous Mesenchymal Stem Cells Derived From Expanded Adipose Tissue (ASC), for Treatment of Complex Perianal Fistulizing Disease in Patients Without IBD. Completed NCT01803347 Phase 3 ◦Drug: ASCs. + fibrin glue;fibrin glue
12 Seton Placement vs. Surgisis Anal Fistula Plug Insertion for Perirectal Fistula: A Prospective Randomized Study Completed NCT00450671 Phase 3
13 A Phase III Multicenter, Single Blind, Randomized, Comparative and add-on Clinical Trial, in Three Parallel Groups, to Evaluate Efficacy and Safety of a New Therapy With Adipose-derived Autologous Stem Cells for the Treatment of Complex Perianal Fistulas in Patients Without Inflammatory Bowel Disease Completed NCT00475410 Phase 3 ASCs (Cx401, company code);Fibrin adhesive
14 Adalimumab for the Treatment of Perianal Fistulas in Crohn's Disease More Effective Alone or Combined to Ciprofloxacin Completed NCT00736983 Phase 3 adalimumab;ciprofloxacin
15 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
16 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
17 A Follow-up of a Phase 3 Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel in the Treatment of Complex Perianal Fistula in Subjects With Crohn's Disease Who Have Participated in ADMIRE II Study Recruiting NCT04075825 Phase 3
18 Treatment of Perianal Fistulas in Crohn´s Disease Patients With Autologous Adipose Tissue Injection: A Randomized and Placebocontrolled Study Recruiting NCT03904212 Phase 2, Phase 3
19 Randomized, Single-blind, Placebo Controlled Multicenter Phase III Study to Assess the Efficacy and Safety of Expanded Autologous Adipose-derived Stem Cells (ASCs) (CX-401), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease Terminated NCT01378390 Phase 3 Expanded autologous adipose-derived adult stem cells (eASCs);Placebo
20 Seton or Glue for Trans-sphincteric Anal Fistulas. A Prospective Randomised Clinical Trial Terminated NCT00929630 Phase 3
21 Phase II Clinical Trial, Multicentre, Randomised and Comparative, to Evaluate the Efficacy and Safety of a New Therapy With Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula Unknown status NCT00115466 Phase 2
22 A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas Unknown status NCT02456324 Phase 2
23 A Phase IIa Clinical Trial to Study the Treatment of the Extremely Complex and Conventional Treatment Resistant Perianal Fistulae With Autologous Stem Cells From Lipoaspirate Unknown status NCT01586715 Phase 2 Adipose-derived stem cells without expanded
24 Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study Unknown status NCT02403232 Phase 2
25 Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula Completed NCT01612195 Phase 2
26 An Open Prospective Study Evaluating the Efficacy and Safety of a Medical Device,KULIST, for the Treatment of Chronic, Non-complicated Perianal Fistulas Completed NCT01462747 Phase 2
27 Multicenter Phase I/IIa Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease. Completed NCT01372969 Phase 1, Phase 2 Cx601
28 Evaluation of Effectiveness and Safety of Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula Completed NCT03643614 Phase 1
29 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With High, Transsphincteric Cryptoglandular Perianal Fistulas Completed NCT02589119 Phase 1 MSC-AFP
30 Re-treatment for Partial or Non-responders for a Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Perianal Fistulas Completed NCT03209700 Phase 1 MSC-AFP
31 An Open-Label, Single-Center, Investigator Initiated Phase 1B Trial of E-CEL UVEC as an Adjunct Cell Therapy for Treatment of Anal Fistulas Recruiting NCT04190862 Phase 1 E-CEL UVEC
32 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease: Pediatric Sub-study Recruiting NCT03449069 Phase 1 MSC-AFP
33 A Phase I Study of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Ileal Anal Anastomosis and Ileal Pouch Fistulas in the Setting of Crohn's Disease of the Pouch Not yet recruiting NCT04073472 Phase 1 mesenchymal stem cells (MSCs)
34 An Outcome and Cost Analysis of Anal Fistula Plug Versus Endorectal Advancement Flap in Complex Anal Fistulae Unknown status NCT01931371
35 Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula: A Novel Strategy for Managing Anal Fistula Unknown status NCT01929525
36 A Multicenter Clinical Trial to Evaluate the Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula Unknown status NCT00951002
37 A Randomized, Prospective, Multi-Centered Study Comparing Clinical Outcomes of the Ligation of Intersphincteric Fistula Tract (LIFT)Procedure Versus Use of Anal Fistula Plug (AFP)in the Surgical Repair of Trans-Sphincteric Anal Fistulae of Cryptoglandular Origin Unknown status NCT00830661
38 Ligation of Intersphincteric Fistula Tract (LIFT) Versus Rectal Advanced Mucosal Flap (RAF) in Surgical Treatment of High Perianal Fistulas Unknown status NCT01997645
39 A Randomized Controlled Trial on the Effect of Topical Phenytoin 2% on Wound Healing After Fistulotomy Unknown status NCT03096522 Phenytoin 2% spray
40 A National, Multicenter, Randomized Open-Label Study of Proctological Surgery Efficacy on Anoperineal Fistulas Healing in Crohn's Disease Patients Treated With Adalimumab. (Official French Title: "Étude Nationale, Multicentrique, randomisée et en Ouvert de l'efficacité de la Chirurgie Proctologique Sur la Cicatrisation Des Fistules anopérinéales de la Maladie de Crohn Chez Des Patients traités Par Adalimumab") Unknown status NCT01388257
41 Multicenter Prospective Evaluation of Radiofrequency for Anal Fistulas Unknown status NCT03131297
42 Use of Platelet Rich Plasma (PRP) as an Adjunct in the Treatment of High Peri-anal Fistulas. Unknown status NCT01615302
43 Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences Unknown status NCT02883296
44 LIFT Technique Versus Seton in Management of Anal Fistula Unknown status NCT03311035
45 Comparison of Post Operative Outcome of VAAFT vs SETON Tightening in the Management of High Perianal Fistula Unknown status NCT02313597
46 Prospective Open-label Study of the Efficacy of the Addition of Hyperbaric Oxygen to the Treatment of Patients With Perianal Fistulas Already Treated With TNF Alpha Blockers Unknown status NCT01828190
47 Assessment of the Natural History and Treatment Outcomes for Patients With Fistula - a Pro- and Retrospective Cohort Study Unknown status NCT03003351
48 A Randomised Feasibility Trial to Investigate the Timing of HDR Brachytherapy With EBRT in Intermediate and High Risk Localised Prostate CAncer Patients and Its Effects on Toxicity and Quality of Life Unknown status NCT02618161
49 A Randomized Clinical Trial Comparing Surgisis AFP to Advancement Flap for the Repair of Anal Fistulas Completed NCT00545441
50 Long-term Clinical Results With the Use of an Anal Fistula Plug for the Treatment of Trans-sphincteric Anal Fistulas Completed NCT04319861

Search NIH Clinical Center for Anal Fistula

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Anal Fistula cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: rectal fistula

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

MalaCards organs/tissues related to Anal Fistula:

Skin, Prostate, Bone, Colon, Small Intestine, Bone Marrow, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Anal Fistula:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Anal Fistula

Articles related to Anal Fistula:

(show top 50) (show all 1273)
# Title Authors PMID Year
Pre-surgery assessment of anal fistula. 61
32303931 2020
Anal fistula associated with anal fissure. 61
32476079 2020
Video-Assisted Anal Fistula Treatment (VAAFT) for complex anorectal fistula: efficacy and risk factors for failure at 3-year follow-up. 61
32318991 2020
Salvage Focal Cryotherapy Offers Similar Short-term Oncologic Control and Improved Urinary Function Compared With Salvage Whole Gland Cryotherapy for Radiation-resistant or Recurrent Prostate Cancer. 61
31892490 2020
Loss of seton in patients with complex anal fistula: a retrospective comparison of conventional knotted loose seton and knot-free seton. 61
32562152 2020
A Multicenter Randomized Controlled Trial Comparing Safety, Efficacy, and Cost-effectiveness of the Surgisis Anal Fistula Plug Versus Surgeon's Preference for Transsphincteric Fistula-in-Ano: The FIAT Trial. 61
32516229 2020
An uninvited commentary on "Comparison of surgical outcomes between video-assisted anal fistula treatment and fistulotomy plus seton for complex anal fistula: A propensity score matching analysis - Retrospective cohort study" [Int. J. Surg. 75 (2020) 99-100]. 61
32535259 2020
A rectal neuroendocrine tumor in a patient with Crohn's disease: a case report and literature review. 61
31705376 2020
Long-term Outcomes of Laser Ablation of Fistula Tract for Fistula-in-Ano: A Considerable Option in Sphincter Preservation. 61
32109917 2020
Pilonidal sinus of the perianal region: Difficult to diagnose. 61
32534417 2020
The informational and decisional preferences of patients undergoing surgery for Crohn's anal fistula: a qualitative study. 61
31868981 2020
Long-term healing after complex anal fistula repair in patients with Crohn's disease. 61
32537672 2020
How to deal with complex anal fistula in an immunosuppressed patient. 61
32533736 2020
Small modifications can obtain good results when treating high transsphincteric anal fistula with LIFT. 61
32193668 2020
Lift and VAAFT for high trans-sphincteric anal fistula: a single center retrospective analysis. 61
32300885 2020
Video-Assisted Anal Fistula Treatment for Treatment of Complex Cryptoglandular Anal Fistulas with 2 Years Follow-Up Period: Our Experience. 61
32412822 2020
[Extraintestinal manifestations and intestinal complications in children with Crohn's disease: an analysis of 54 cases]. 61
32434644 2020
Recurrent anal fistulas: When, why, and how to manage? 61
32432136 2020
Could FiLaC™ be effective in the treatment of anal fistulas? A systematic review of observational studies and proportional meta-analysis. 61
32445614 2020
The effect of suture selection in complex anal fistulas on the success of cutting seton placement and patient comfort. 61
32494280 2020
Formation rate of secondary anal fistula after incision and drainage of perianal Sepsis and analysis of risk factors. 61
32375721 2020
Novel use of video assisted anal fistula treatment (VAAFT) fistuloscope in the treatment of chronic sinus tracts following low anterior resection. 61
32461016 2020
Should the search for ganglia in the distal rectal fistula in patients with anorectal malformation be abandoned? 61
32345500 2020
Fistulectomy and primary sphincteroplasty (FIPS) to prevent keyhole deformity in simple anal fistula: a single-center retrospective cohort study. 61
32253992 2020
The LIFT (ligation of the intersphincteric fistula tract) procedure for a transsphincteric posterior anal fistula - a video vignette. 61
32356385 2020
An invited commentary on "Comparison of surgical outcomes between video-assisted anal fistula treatment and fistulotomy plus seton for complex anal fistula: A propensity score matching analysis - Retrospective cohort" [Int. J. Surg. 75 (2020) 99-104]. 61
32169569 2020
Hot topics in global perianal fistula research: A scopus-based bibliometric analysis. 61
32332609 2020
Post hemorrhoidectomy complications: CT imaging findings. 61
31927497 2020
It is time to retire Goodsall's Rule: the Midline Rule is a more accurate predictor of the true and natural course of anal fistulas. 61
32107684 2020
What urologists need to know about male to female genital confirmation surgery (vaginoplasty): techniques, complications and how to deal with them. 61
32003205 2020
Inflammatory bowel disease symptoms at the time of anal fistula lead to the diagnosis of Crohn's disease. 61
32336615 2020
Perianal fistula and the ileoanal pouch - different aetiologies require distinct evaluation. 61
32304181 2020
Diagnosis of Tubercular Anal Fistula. 61
32132469 2020
Presence of coccydynia after treatment for anal fistula: recognition and treatment to avoid patient dissatisfaction. 61
32348619 2020
Combined Fistulotomy and Contralateral Anal Internal Sphincterotomy for Recurrent and Complex Anal Fistula to Prevent Recurrence. 61
32178490 2020
Initial Experience With Video-Assisted Anal Fistula Treatment in the Philippines. 61
32178505 2020
Longterm outcome of anal fistula - A retrospective study. 61
32300218 2020
[An atypical presentation of a peri-anal fistula]. 61
31126868 2020
Comparison of surgical outcomes between video-assisted anal fistula treatment and fistulotomy plus seton for complex anal fistula: A propensity score matching analysis - Retrospective cohort study. 61
32014596 2020
The development of a cryptoglandular Anal Fistula Core Outcome Set (AFCOS): an international Delphi study protocol. 61
32213065 2020
Laparoscopic surgical technique to enhance the management of anorectal malformations: 330 cases' experience in a single center. 61
31919580 2020
Comparison of Ligation of the Intersphincteric Fistula Tract and BioLIFT for the Treatment of Transsphincteric Anal Fistula: A Retrospective Analysis. 61
32032144 2020
Video-assisted anal fistula treatment in combination with ligation of the intersphincteric fistula tract in the treatment of complex transsphincteric fistulas - a video vignette. 61
32198908 2020
Development of screening tools to predict the risk of recurrence and related complications following anal fistula surgery: protocol for a prospective cohort study. 61
32139494 2020
Colorectal Surgery Review for Primary Care Providers. 61
32308242 2020
Ligation of intersphincteric fistula tract (LIFT) in treatment of anal fistula: An updated systematic review, meta-analysis, and meta-regression of the predictors of failure. 61
31648932 2020
Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula. 61
31320233 2020
Video-assisted anal fistula treatment for complex anal fistula: a long-term follow-up study. 61
32030874 2020
Evaluation and management of perianal abscess and anal fistula: SICCR position statement. 61
31974827 2020
Permacol™ collagen paste injection for the treatment of complex anal fistula - a video vignette. 61
31465614 2020

Variations for Anal Fistula

Expression for Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for Anal Fistula

Pathways related to Anal Fistula according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.59 TNF S100A7 MMP9 DEFB4A
2 11.55 MSH2 MLH1 AFP
3 11.24 TNF MSH2 MMP9 MLH1 EGF
4 11.13 TNF MMP9 EGF

GO Terms for Anal Fistula

Cellular components related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF S100A7 MMP9 EGF DEFB4A DEFB103B
2 extracellular region GO:0005576 9.23 TNF S100A7 MMP9 EGF DEFB4A DEFB103B
3 mismatch repair complex GO:0032300 8.96 MSH2 MLH1

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.67 TNF DEFB4A DEFB103B
2 defense response to Gram-positive bacterium GO:0050830 9.61 TNF DEFB4A DEFB103B
3 defense response to Gram-negative bacterium GO:0050829 9.58 S100A7 DEFB4A DEFB103B
4 antimicrobial humoral response GO:0019730 9.5 S100A7 DEFB4A DEFB103B
5 isotype switching GO:0045190 9.48 MSH2 MLH1
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.46 MSH2 MLH1
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 MSH2 MLH1
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MSH2 MLH1
9 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MSH2 MLH1
10 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.13 TNF MSH2 MLH1
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.16 MSH2 MLH1
2 CCR6 chemokine receptor binding GO:0031731 8.96 DEFB4A DEFB103B
3 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Anal Fistula

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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