Anal Fistula

Categories: Gastrointestinal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Anal Fistula

MalaCards integrated aliases for Anal Fistula:

Name: Anal Fistula 12 58 15 37 32
Anorectal Fistula 71 32
Rectal Fistula 43 32


Orphanet epidemiological data:

anal fistula
Prevalence: 1-5/10000 (Europe);


Orphanet: 58  
Rare gastroenterological diseases

External Ids:

Disease Ontology 12 DOID:0060328
MeSH 43 D012003
ICD10 via Orphanet 33 K60.3
UMLS via Orphanet 72 C0205929
Orphanet 58 ORPHA228113
UMLS 71 C0149889

Summaries for Anal Fistula

Disease Ontology : 12 An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.

MalaCards based summary : Anal Fistula, also known as anorectal fistula, is related to rectum cancer and adenocarcinoma. An important gene associated with Anal Fistula is DEFB103B (Defensin Beta 103B), and among its related pathways/superpathways are NOD-like receptor signaling pathway and IL-17 Family Signaling Pathways. The drugs Adalimumab and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include Adipose.

Wikipedia : 74 Anal fistula is a chronic abnormal communication between the epithelialised surface of the anal canal... more...

Related Diseases for Anal Fistula

Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 rectum cancer 30.4 MSH2 MLH1 APOLD1
2 adenocarcinoma 30.4 MSH2 MMP9 MLH1 EGF
3 rectum adenocarcinoma 30.0 MSH2 MLH1 APOLD1
4 transitional cell carcinoma 29.8 MSH2 MMP9 MLH1
5 colorectal adenocarcinoma 29.7 MSH2 MMP9 MLH1 EGF
6 anorectal stricture 29.6 TNF APOLD1
7 gastric ulcer 29.3 TNF MMP9 EGF
8 inflammatory bowel disease 29.2 TNF MMP9 MLH1 EGF DEFB4A
9 hemorrhoid 29.0 MMP9 MIR6086 MIR3609 MIR1185-1 APOLD1
10 ulcerative colitis 28.7 TNF MSH2 MLH1
11 nijmegen breakage syndrome 11.3
12 crohn's disease 10.8
13 osteonecrosis of the jaw 10.4 DEFB4A DEFB103B
14 mucinous adenocarcinoma 10.3
15 appendix adenocarcinoma 10.3
16 renal pelvis transitional cell carcinoma 10.3 MSH2 MLH1
17 adenosquamous colon carcinoma 10.3 MSH2 MLH1
18 extrahepatic bile duct adenoma 10.3 MSH2 MLH1
19 appendix carcinoid tumor 10.3 MSH2 MLH1
20 cervicitis 10.3 DEFB4A DEFB103B
21 cervical adenoma malignum 10.3 MSH2 MLH1
22 jejunal cancer 10.3 MSH2 MLH1
23 autosomal dominant non-syndromic intellectual disability 8 10.3 MSH2 MLH1
24 colorectal cancer, hereditary nonpolyposis, type 6 10.3 MSH2 MLH1
25 lower lip cancer 10.3 MSH2 MLH1
26 sebaceous gland neoplasm 10.3 MSH2 MLH1
27 colorectal cancer, hereditary nonpolyposis, type 5 10.3 MSH2 MLH1
28 proctitis 10.3
29 small intestine adenocarcinoma 10.3 MSH2 MLH1
30 duodenum adenocarcinoma 10.3 MSH2 MLH1
31 mental retardation, autosomal dominant 20 10.3 MSH2 MLH1
32 internal hemorrhoid 10.2 MMP9 APOLD1
33 hidradenitis suppurativa 10.2
34 hidradenitis 10.2
35 47,xyy 10.2
36 endometrioid ovary carcinoma 10.2 MSH2 MLH1
37 melanocytic nevus syndrome, congenital 10.2 MSH2 MLH1
38 dysplastic nevus syndrome 10.2 MSH2 MLH1
39 pilonidal sinus 10.2
40 mycobacterium tuberculosis 1 10.2
41 crohn's colitis 10.2
42 pulmonary tuberculosis 10.2
43 female reproductive endometrioid cancer 10.2 MSH2 MLH1
44 anal squamous cell carcinoma 10.2 MLH1 APOLD1
45 ductal carcinoma in situ 10.1 S100A7 MMP9 EGF
46 cholesteatoma of middle ear 10.1 MMP9 EGF DEFB4A
47 sebaceous adenoma 10.1 MSH2 MLH1 EGF
48 duodenum disease 10.1 MSH2 MLH1
49 ovary adenocarcinoma 10.1 MSH2 MLH1 EGF
50 squamous cell carcinoma 10.1

Graphical network of the top 20 diseases related to Anal Fistula:

Diseases related to Anal Fistula

Symptoms & Phenotypes for Anal Fistula

Drugs & Therapeutics for Anal Fistula

Drugs for Anal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Adalimumab Approved Phase 4 331731-18-1 16219006
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Prilocaine Approved Phase 4 721-50-6 4906
5 Anesthetics, General Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antirheumatic Agents Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Cyclooxygenase Inhibitors Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Analgesics Phase 4
12 Adjuvants, Anesthesia Phase 4
13 Analgesics, Opioid Phase 4
14 Anesthetics, Intravenous Phase 4
15 Endorphins Phase 2, Phase 3
16 Melanocyte-Stimulating Hormones Phase 2, Phase 3
17 beta-endorphin Phase 2, Phase 3
18 Adrenocorticotropic Hormone Phase 2, Phase 3
19 Fibrin Tissue Adhesive Phase 3
20 Hemostatics Phase 3
21 Coagulants Phase 3
22 Calamus Phase 2
23 Charcoal Phase 2
24 silver nitrate Approved, Investigational
Phenytoin Approved, Vet_approved 57-41-0 1775
Aminolevulinic acid Approved 106-60-5 137
Turmeric Approved, Experimental, Investigational
Clavulanate Approved, Vet_approved 58001-44-8 5280980
Amoxicillin Approved, Vet_approved 26787-78-0 33613
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
Povidone-iodine Approved 25655-41-8
Acetylcholine Approved, Investigational 51-84-3 187
Acetaminophen Approved 103-90-2 1983
Ketamine Approved, Vet_approved 6740-88-1 3821
Gabapentin Approved, Investigational 60142-96-3 3446
Ciprofloxacin Approved, Investigational 85721-33-1 2764
Acetylcysteine Approved, Investigational 616-91-1 12035
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
Clindamycin Approved, Vet_approved 18323-44-9 29029
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
Metronidazole Approved 443-48-1 4173
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
46 Adrenergic Antagonists
47 Adrenergic alpha-Antagonists
48 Adrenergic Agents
49 Androgens
50 Anti-Infective Agents, Local

Interventional clinical trials:

(show top 50) (show all 102)
# Name Status NCT ID Phase Drugs
1 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Unknown status NCT02423330 Phase 4
2 EUS Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
3 Double-blinded Multicenter Randomized Clinical Trial to Evaluate the Efficacy and Safety of CLIFE1 and CLIFE2 Gels in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
4 The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
5 Anal fistUla Repair With Platelet-Rich plasmA (AURoRA) Withdrawn NCT02678936 Phase 4
6 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
7 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair: a Multicenter, Randomized, Open-label, Parallel Controlled Trial Unknown status NCT01478139 Phase 3
8 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Unknown status NCT02336867 Phase 2, Phase 3
9 The Safety and Efficiacy of Local MSC Injection in the Treatment of Fistulas in Patients With Perianal Crohn's Disease Unknown status NCT03056664 Phase 2, Phase 3
10 Multicentre,Randomized,Comparative,Add-on,Into Two Parallel Groups Clinical Trial to Evaluate Efficacy and Safety of Autologous Mesenchymal Stem Cells Derived From Expanded Adipose Tissue (ASC), for Treatment of Complex Perianal Fistulizing Disease in Patients Without IBD. Completed NCT01803347 Phase 3 ◦Drug: ASCs. + fibrin glue;fibrin glue
11 Seton Placement vs. Surgisis Anal Fistula Plug Insertion for Perirectal Fistula: A Prospective Randomized Study Completed NCT00450671 Phase 3
12 A Phase III Multicenter, Single Blind, Randomized, Comparative and add-on Clinical Trial, in Three Parallel Groups, to Evaluate Efficacy and Safety of a New Therapy With Adipose-derived Autologous Stem Cells for the Treatment of Complex Perianal Fistulas in Patients Without Inflammatory Bowel Disease Completed NCT00475410 Phase 3 ASCs (Cx401, company code);Fibrin adhesive
13 Adalimumab for the Treatment of Perianal Fistulas in Crohn's Disease More Effective Alone or Combined to Ciprofloxacin Completed NCT00736983 Phase 3 adalimumab;ciprofloxacin
14 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
15 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
16 Treatment of Perianal Fistulas in Crohn´s Disease Patients With Autologous Adipose Tissue Injection: A Randomized and Placebocontrolled Study Recruiting NCT03904212 Phase 2, Phase 3
17 A Follow-up of a Phase 3 Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel in the Treatment of Complex Perianal Fistula in Subjects With Crohn's Disease Who Have Participated in ADMIRE II Study Recruiting NCT04075825 Phase 3
18 Randomized, Single-blind, Placebo Controlled Multicenter Phase III Study to Assess the Efficacy and Safety of Expanded Autologous Adipose-derived Stem Cells (ASCs) (CX-401), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease Terminated NCT01378390 Phase 3 Expanded autologous adipose-derived adult stem cells (eASCs);Placebo
19 Seton or Glue for Trans-sphincteric Anal Fistulas. A Prospective Randomised Clinical Trial Terminated NCT00929630 Phase 3
20 Phase II Clinical Trial, Multicentre, Randomised and Comparative, to Evaluate the Efficacy and Safety of a New Therapy With Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula Unknown status NCT00115466 Phase 2
21 A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas Unknown status NCT02456324 Phase 2
22 A Phase IIa Clinical Trial to Study the Treatment of the Extremely Complex and Conventional Treatment Resistant Perianal Fistulae With Autologous Stem Cells From Lipoaspirate Unknown status NCT01586715 Phase 2 Adipose-derived stem cells without expanded
23 Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study Unknown status NCT02403232 Phase 2
24 Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula Completed NCT01612195 Phase 2
25 An Open Prospective Study Evaluating the Efficacy and Safety of a Medical Device,KULIST, for the Treatment of Chronic, Non-complicated Perianal Fistulas Completed NCT01462747 Phase 2
26 Multicenter Phase I/IIa Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease. Completed NCT01372969 Phase 1, Phase 2 Cx601
27 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With High, Transsphincteric Cryptoglandular Perianal Fistulas Completed NCT02589119 Phase 1 MSC-AFP
28 An Open-Label, Single-Center, Investigator Initiated Phase 1B Trial of E-CEL UVEC as an Adjunct Cell Therapy for Treatment of Anal Fistulas Recruiting NCT04190862 Phase 1 E-CEL UVEC
29 A Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease: Pediatric Sub-study Recruiting NCT03449069 Phase 1 MSC-AFP
30 Evaluation of Effectiveness and Safety of Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula Active, not recruiting NCT03643614 Phase 1
31 Re-treatment for Partial or Non-responders for a Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Perianal Fistulas Active, not recruiting NCT03209700 Phase 1 MSC-AFP
32 A Phase I Study of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Ileal Anal Anastomosis and Ileal Pouch Fistulas in the Setting of Crohn's Disease of the Pouch Not yet recruiting NCT04073472 Phase 1 mesenchymal stem cells (MSCs)
33 An Outcome and Cost Analysis of Anal Fistula Plug Versus Endorectal Advancement Flap in Complex Anal Fistulae Unknown status NCT01931371
34 Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula: A Novel Strategy for Managing Anal Fistula Unknown status NCT01929525
35 A Multicenter Clinical Trial to Evaluate the Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula Unknown status NCT00951002
36 A Randomized, Prospective, Multi-Centered Study Comparing Clinical Outcomes of the Ligation of Intersphincteric Fistula Tract (LIFT)Procedure Versus Use of Anal Fistula Plug (AFP)in the Surgical Repair of Trans-Sphincteric Anal Fistulae of Cryptoglandular Origin Unknown status NCT00830661
37 Ligation of Intersphincteric Fistula Tract (LIFT) Versus Rectal Advanced Mucosal Flap (RAF) in Surgical Treatment of High Perianal Fistulas Unknown status NCT01997645
38 A Randomized Controlled Trial on the Effect of Topical Phenytoin 2% on Wound Healing After Fistulotomy Unknown status NCT03096522 Phenytoin 2% spray
39 A National, Multicenter, Randomized Open-Label Study of Proctological Surgery Efficacy on Anoperineal Fistulas Healing in Crohn's Disease Patients Treated With Adalimumab. (Official French Title: "Étude Nationale, Multicentrique, randomisée et en Ouvert de l'efficacité de la Chirurgie Proctologique Sur la Cicatrisation Des Fistules anopérinéales de la Maladie de Crohn Chez Des Patients traités Par Adalimumab") Unknown status NCT01388257
40 Multicenter Prospective Evaluation of Radiofrequency for Anal Fistulas Unknown status NCT03131297
41 Use of Platelet Rich Plasma (PRP) as an Adjunct in the Treatment of High Peri-anal Fistulas. Unknown status NCT01615302
42 Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences Unknown status NCT02883296
43 A Pilot Study to Assess the Efficacy of an Anorectal Fistula Plug With Sealing of the Internal Opening (Curaseal AF) as a Treatment for Perianal Fistula Unknown status NCT03381365
44 Prospective Open-label Study of the Efficacy of the Addition of Hyperbaric Oxygen to the Treatment of Patients With Perianal Fistulas Already Treated With TNF Alpha Blockers Unknown status NCT01828190
45 Assessment of the Natural History and Treatment Outcomes for Patients With Fistula - a Pro- and Retrospective Cohort Study Unknown status NCT03003351
46 A Randomised Feasibility Trial to Investigate the Timing of HDR Brachytherapy With EBRT in Intermediate and High Risk Localised Prostate CAncer Patients and Its Effects on Toxicity and Quality of Life Unknown status NCT02618161
47 A Randomized Clinical Trial Comparing Surgisis AFP to Advancement Flap for the Repair of Anal Fistulas Completed NCT00545441
48 A Single-center Single Arm Prospective Study Evaluating the Surgisis Biodesign Anal Fistula Plug Completed NCT00703131
49 Ligation of the Intersphincteric Fistula Tract With Tissue Graft Placement for Treatment of Persistent Trans-sphincteric Anal Fistula Completed NCT01602081
50 Fistuolotomy With or Without Marsupialization for Treatment of Simple Anal Fistula: a Randomized Controlled Trial Completed NCT03595839

Search NIH Clinical Center for Anal Fistula

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Anal Fistula cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: rectal fistula

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

MalaCards organs/tissues related to Anal Fistula:

Prostate, Skin, Colon, Bone, Small Intestine, Kidney, Ovary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Anal Fistula:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Anal Fistula

Articles related to Anal Fistula:

(show top 50) (show all 1234)
# Title Authors PMID Year
Comparison of Ligation of the Intersphincteric Fistula Tract and BioLIFT for the Treatment of Transsphincteric Anal Fistula: A Retrospective Analysis. 61
32032144 2020
Ligation of intersphincteric fistula tract (LIFT) in treatment of anal fistula: An updated systematic review, meta-analysis, and meta-regression of the predictors of failure. 61
31648932 2020
Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula. 61
31320233 2020
Video-Assisted Anal Fistula Treatment for complex anal fistula: a long-term follow-up study. 61
32030874 2020
Comparison of surgical outcomes between video-assisted anal fistula treatment and fistulotomy plus seton for complex anal fistula: A propensity score matching analysis - Retrospective cohort study. 61
32014596 2020
Evaluation and management of perianal abscess and anal fistula: SICCR position statement. 61
31974827 2020
Treatment of anal fistula with Baccharis dracunculifolia extract. Experimental study in rats. 61
31967191 2020
Clinical Effect of Tunnel-Like Fistulectomy Plus Draining Seton Combined with Incision of Internal Opening of Anal Fistula (TFSIA) in the Treatment of High Trans-Sphincteric Anal Fistula. 61
31929499 2020
Permacol™ collagen paste injection for the treatment of complex anal fistula - a video vignette. 61
31465614 2020
[Long-term efficacy of bioprosthetic anal fistula plug in the treatment of transsphincteric anal fistula]. 61
31958934 2020
Laparoscopic surgical technique to enhance the management of anorectal malformations: 330 cases' experience in a single center. 61
31919580 2020
What urologists need to know about male to female genital confirmation surgery (vaginoplasty): techniques, complications and how to deal with them. 61
32003205 2020
Cytomegalovirus enteritis with intractable diarrhea in infants from a tertiary care center in China. 61
31917930 2020
Magnetic resonance imaging findings in patients with initial manifestations of perianal fistulas. 61
32026703 2020
Ustekinumab for Crohn's Disease: Results of the ICC Registry, a Nationwide Prospective Observational Cohort Study. 61
31219157 2020
Salvage Focal Cryotherapy Offers Similar Short-term Oncologic Control and Improved Urinary Function Compared With Salvage Whole Gland Cryotherapy for Radiation-resistant or Recurrent Prostate Cancer. 61
31892490 2019
Hemigland Cryoablation of Localized Low, Intermediate and High Risk Prostate Cancer: Oncologic and Functional Outcomes at 5 Years. 61
31347953 2019
Drained mucosal advancement flap versus rerouting Seton around the internal anal sphincter in treatment of high trans-sphincteric anal fistula: A randomized trial. 61
31751790 2019
Post hemorrhoidectomy complications: CT imaging findings. 61
31927497 2019
The informational and decisional preferences of patients undergoing surgery for Crohn's anal fistula: a qualitative study. 61
31868981 2019
Video-assisted anal fistula treatment (VAAFT) assisted seton placement - a video vignette. 61
31400250 2019
[Investigation of treatment and analysis of prognostic risk on enterocutaneous fistula in China: a multicenter prospective study]. 61
31770835 2019
A comparable method to Gd-contrast enhancement in the preoperative evaluation of anal fistula. 61
31689864 2019
A new understanding of the principles in the management of complex anal fistula. 61
31421428 2019
A Commentary on the article: "Risk factors for recurrence after anal fistula surgery: A meta-analysis", Int J Surg 2019;69:153-164. 61
31546034 2019
A comparative study on the effectiveness of rectal advancement flap and seton placement surgeries in patients with anal fistula on the rate of recurrence, incontinence and infection. 61
31803658 2019
A rectal neuroendocrine tumor in a patient with Crohn's disease: a case report and literature review. 61
31705376 2019
The Ligation of Intersphincteric Fistula Tract Technique: A Preliminary Experience. 61
31725998 2019
Commentary on: Risk factors for recurrence after anal fistula surgery: A meta-analysis. 61
31499224 2019
Fistulotomy and primary sphincteroplasty for anal fistula: long-term data on continence and patient satisfaction. 61
31538298 2019
Complex anal fistula involving male genital tract: a new diagnostic entity. 61
31645379 2019
[Clinical therapeutic observation on sequential treatment of chronic wounds with repeated recurrence of hidradenitis suppurativa in buttocks]. 61
31658548 2019
Relationship Between Body Mass Index and Recurrence/Anal Fistula Formation Following Initial Operation for Anorectal Abscess. 61
31642447 2019
Anal fistula and pilonidal sinus disease coexisting simultaneously: An audit in a cohort of 1284 patients. 61
31412425 2019
Photodynamic Therapy for the Treatment of Complex Anal Fistula. 61
31536149 2019
Risk Factors for Recurrence after anal fistula surgery: A meta-analysis. 61
31400504 2019
Fistulotomy with or without marsupialisation of wound edges in treatment of simple anal fistula: a randomised controlled trial. 61
31155896 2019
Successful Closure of a Rectal Fistula of Crohn's Disease Using Endoscopic Submucosal Dissection Combined With an Over-the-Scope Clip. 61
31397677 2019
Efficacy of flap repair for anal fistula: study protocol for a systematic review of randomized controlled trial. 61
31415418 2019
Drainage Seton Versus External Anal Sphincter-Sparing Seton After Rerouting of the Fistula Tract in the Treatment of Complex Anal Fistula: A Randomized Controlled Trial. 61
31162376 2019
Sphincter-sparing surgery for complex anal fistulas: radiofrequency thermocoagulation of the tract is of no help. 61
30897291 2019
One stage fistulectomy for high anal fistula with reconstruction of anal sphincter without fecal diversion. 61
30738718 2019
Contemporary surgical practice in the management of anal fistula: results from an international survey. 61
31368010 2019
Stereotactic Body Radiation Therapy Boost for Intermediate-Risk Prostate Cancer: A Phase 1 Dose-Escalation Study. 61
31002941 2019
A rare case of rectal cancer with perianal metastasis: a case report. 61
31429762 2019
Prevalence of anal fistula in the United Kingdom. 61
31417925 2019
Outcome Of Use Of 1% Silver Nitrate In Patients With Low Lying Perianal Fistula. 61
31535505 2019
Platelet-rich plasma (PRP) versus fibrin glue in cryptogenic fistula-in-ano: a phase III single-center, randomized, double-blind trial. 61
31037566 2019
A randomized controlled trial on the effect of topical phenytoin 2% on wound healing after anal fistulotomy. 61
30740877 2019
Can Perianal Fistula Be Treated Non-surgically with Platelet-Rich Fibrin Sealant? 61
30187327 2019

Variations for Anal Fistula

Expression for Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for Anal Fistula

Pathways related to Anal Fistula according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.69 TNF DEFB4A DEFB103B
Show member pathways
11.59 TNF S100A7 MMP9 DEFB4A
3 11.24 TNF MSH2 MMP9 MLH1 EGF
4 11.13 TNF MMP9 EGF
5 10.78 MSH2 MLH1

GO Terms for Anal Fistula

Cellular components related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 TNF S100A7 MMP9 EGF DEFB4A DEFB103B
2 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.67 DEFB103B DEFB4A TNF
2 defense response to Gram-positive bacterium GO:0050830 9.61 DEFB103B DEFB4A TNF
3 defense response to Gram-negative bacterium GO:0050829 9.54 DEFB103B DEFB4A S100A7
4 positive regulation of DNA binding GO:0043388 9.51 EGF MMP9
5 antimicrobial humoral response GO:0019730 9.5 DEFB103B DEFB4A S100A7
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.48 MLH1 MSH2
7 isotype switching GO:0045190 9.46 MLH1 MSH2
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 MLH1 MSH2
9 somatic recombination of immunoglobulin gene segments GO:0016447 9.26 MLH1 MSH2
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MLH1 MSH2
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.13 MLH1 MSH2 TNF
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.16 MSH2 MLH1
2 CCR6 chemokine receptor binding GO:0031731 8.96 DEFB4A DEFB103B
3 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Anal Fistula

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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