MCID: ANL016
MIFTS: 22

Anal Margin Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Anal Margin Carcinoma

MalaCards integrated aliases for Anal Margin Carcinoma:

Name: Anal Margin Carcinoma 12 15
Carcinoma of Anal Margin 12 70
Perianal Skin Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4284
NCIt 50 C7472
SNOMED-CT 67 255084004
UMLS 70 C0349534

Summaries for Anal Margin Carcinoma

Disease Ontology : 12 An anal carcinoma that has material basis in abnormally proliferating cells derives from epithelial cells and is located in the anal margin (where the canal meets the outside skin at the anus).

MalaCards based summary : Anal Margin Carcinoma, also known as carcinoma of anal margin, is related to anal margin squamous cell carcinoma and anal margin basal cell carcinoma. An important gene associated with Anal Margin Carcinoma is CCL4 (C-C Motif Chemokine Ligand 4), and among its related pathways/superpathways are IL12-mediated signaling events and TCR signaling in naive CD4+ T cells. Affiliated tissues include anal margin and skin.

Related Diseases for Anal Margin Carcinoma

Diseases related to Anal Margin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 anal margin squamous cell carcinoma 11.3
2 anal margin basal cell carcinoma 11.3
3 anal squamous cell carcinoma 11.3
4 herpes simplex 10.0
5 bacterial infectious disease 10.0 CD4 CCL4
6 ebola hemorrhagic fever 10.0 CD4 CCL4
7 retinal vasculitis 10.0 CD4 CCL4
8 vaginitis 9.9 CD4 CCL4
9 multicentric castleman disease 9.9 CD4 CCL4
10 castleman disease 9.9 CD4 CCL4
11 sarcoidosis 1 9.9 CD4 CCL4
12 human immunodeficiency virus infectious disease 9.9 CD4 CCL4
13 purulent endophthalmitis 9.9 PRF1 CD4
14 oral tuberculosis 9.9 PRF1 CD4
15 phenytoin allergy 9.9 PRF1 CD4
16 demyelinating disease 9.9 CD4 CCL4
17 immunodeficiency 43 9.8 PRF1 CD4
18 blood group, globoside system 9.8 PRF1 CD4
19 viral infectious disease 9.8 CD4 CCL4
20 chickenpox 9.8 PRF1 CD4
21 endocardium disease 9.8 PRF1 CD4
22 listeriosis 9.8 PRF1 CD4
23 coccidiosis 9.8 PRF1 CD4
24 commensal bacterial infectious disease 9.8 PRF1 CD4
25 severe cutaneous adverse reaction 9.8 PRF1 CD4
26 chediak-higashi syndrome 9.8 PRF1 CD4
27 parasitic protozoa infectious disease 9.8 PRF1 CD4
28 pfeiffer syndrome 9.8 PRF1 CD4
29 chronic inflammatory demyelinating polyradiculoneuropathy 9.8 PRF1 CCL4
30 disease by infectious agent 9.8 CD4 CCL4
31 pancytopenia 9.8 PRF1 CD4
32 autoimmune lymphoproliferative syndrome 9.8 PRF1 CD4
33 dermatitis, atopic 9.7 CD4 CCL4
34 hemophagocytic lymphohistiocytosis 9.7 PRF1 CCL4
35 behcet syndrome 9.7 PRF1 CD4
36 celiac disease 1 9.7 PRF1 CD4
37 human immunodeficiency virus type 1 9.7 CD4 CCL4
38 pulmonary fibrosis, idiopathic 9.6 CD4 CCL4
39 primary bacterial infectious disease 9.5 PRF1 CD4 CCL4
40 mycobacterium tuberculosis 1 9.5 PRF1 CD4 CCL4
41 multiple sclerosis 9.5 PRF1 CD4 CCL4

Graphical network of the top 20 diseases related to Anal Margin Carcinoma:



Diseases related to Anal Margin Carcinoma

Symptoms & Phenotypes for Anal Margin Carcinoma

Drugs & Therapeutics for Anal Margin Carcinoma

Search Clinical Trials , NIH Clinical Center for Anal Margin Carcinoma

Genetic Tests for Anal Margin Carcinoma

Anatomical Context for Anal Margin Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Anal Margin Carcinoma:

19
Anal Margin

MalaCards organs/tissues related to Anal Margin Carcinoma:

40
Skin

Publications for Anal Margin Carcinoma

Articles related to Anal Margin Carcinoma:

# Title Authors PMID Year
1
HPV-73- and HPV-82 positive anal margin carcinoma with secondary ulcerating Herpes simplex-virus 2 infection. 61
21143394 2011
2
Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. 61
20184584 2010
3
Patterns of failure and outcome in patients with carcinoma of the anal margin. 61
18231838 2008
4
Squamous cell carcinoma of the anal margin with pruritus ani of long duration. 61
12534524 2003
5
Squamous cell carcinoma of the anus at one hospital from 1948 to 1984. 61
2765832 1989
6
Squamous-cell carcinoma of the anal canal. 61
3057665 1988
7
Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy. 61
3344351 1988
8
The management of anal carcinoma. 61
7225745 1981
9
Squamous Cell Carcinoma of the Anal Canal and Anal Margin. 61
29265281 1972

Variations for Anal Margin Carcinoma

Expression for Anal Margin Carcinoma

Search GEO for disease gene expression data for Anal Margin Carcinoma.

Pathways for Anal Margin Carcinoma

Pathways related to Anal Margin Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.21 CD4 CCL4
2
Show member pathways
10.99 PRF1 CD4
3 10.07 PRF1 CD4

GO Terms for Anal Margin Carcinoma

Biological processes related to Anal Margin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.16 CD4 CCL4
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.96 CD4 CCL4
3 positive regulation of calcium-mediated signaling GO:0050850 8.62 CD4 CCL4

Molecular functions related to Anal Margin Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 PRF1 CD4 CCL4

Sources for Anal Margin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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