MCID: ANL016
MIFTS: 20

Anal Margin Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Anal Margin Carcinoma

MalaCards integrated aliases for Anal Margin Carcinoma:

Name: Anal Margin Carcinoma 12 15
Carcinoma of Anal Margin 12 73
Perianal Skin Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4284
NCIt 50 C7472
SNOMED-CT 68 255084004
UMLS 73 C0349534

Summaries for Anal Margin Carcinoma

Disease Ontology : 12 An anal carcinoma that has material basis in abnormally proliferating cells derives from epithelial cells and is located in the anal margin (where the canal meets the outside skin at the anus).

MalaCards based summary : Anal Margin Carcinoma, also known as carcinoma of anal margin, is related to anal margin squamous cell carcinoma and anal margin basal cell carcinoma. An important gene associated with Anal Margin Carcinoma is TENM1 (Teneurin Transmembrane Protein 1). The drugs Fluorouracil and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include the anal margin (where the canal meets the outside skin at the anus) and skin.

Related Diseases for Anal Margin Carcinoma

Diseases related to Anal Margin Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 anal margin squamous cell carcinoma 11.3
2 anal margin basal cell carcinoma 11.2
3 anal squamous cell carcinoma 11.2
4 herpes simplex 9.8

Symptoms & Phenotypes for Anal Margin Carcinoma

Drugs & Therapeutics for Anal Margin Carcinoma

Drugs for Anal Margin Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
2
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
3
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
4 Mitomycins Phase 3,Phase 2,Phase 1,Early Phase 1
5 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
6 Antimetabolites Phase 3,Phase 2,Phase 1,Early Phase 1
7 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Early Phase 1
8 Alkylating Agents Phase 3,Phase 1,Early Phase 1
9 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Early Phase 1
10 Anti-Bacterial Agents Phase 3,Phase 1,Early Phase 1
11 Antibiotics, Antitubercular Phase 3,Phase 1,Early Phase 1
12 Albumin-Bound Paclitaxel Phase 3,Phase 2
13 Antimitotic Agents Phase 3,Phase 2
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
15
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
16
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
17
Pembrolizumab Approved Phase 2 1374853-91-4
18
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
19
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
20 Antibodies Phase 2,Phase 1
21 Immunoglobulins Phase 2,Phase 1
22 Antibodies, Monoclonal Phase 2,Phase 1
23 taxane Phase 2
24
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
25
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
26
nivolumab Approved Phase 1 946414-94-4
27
Manganese Approved, Nutraceutical Phase 1 7439-96-5 27854
28 Vaccines Phase 1
29 Antirheumatic Agents Phase 1
30 Antineoplastic Agents, Alkylating Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Anal Dysplasia Study of Men Who Have Sex With Men Living With HIV Withdrawn NCT01663558 Phase 4 imiquimod
2 Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Recruiting NCT02369939 Phase 3 Mitomycin C;5-Fluorouracil
3 Efficacy Study of Chemoradiotherapy With or Without Paclitaxel in Squamous-cell Anal Carcinoma Patients Enrolling by invitation NCT02526953 Phase 3 Paclitaxel;Capecitabine;Capecitabine;Mitomycins;Mitomycins
4 Vectibix for the Treatment of Anal Cancer Completed NCT01285778 Phase 2 panitumumab, mytomicin C, 5-FU, radiation
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Oral Rigosertib for Squamous Cell Carcinoma Completed NCT01807546 Phase 2 rigosertib
7 A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma Recruiting NCT03519295 Phase 2 MPDL3280A;mDCF
8 Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection Recruiting NCT02437851 Phase 2
9 Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting NCT02628067 Phase 2
10 Clinical and Biological Interest of Taxanes in Advanced Squamous Cell Anal Carcinoma Active, not recruiting NCT02402842 Phase 2 Docetaxel, Cisplatin and 5-Fluorouracil
11 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil
12 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
13 A Phase 1 Study in Participants With Advanced Cancer Completed NCT01115790 Phase 1 Prexasertib
14 Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer. Completed NCT00423254 Phase 1
15 Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer Recruiting NCT03386500 Phase 1 BMX-001
16 HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA Recruiting NCT02379520 Phase 1 Cytoxan;Fludarabine
17 Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery Recruiting NCT02408861 Phase 1
18 ART: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy Completed NCT02145416
19 Evaluation by MRI of Anal Canal Cell Carcinoma: is There Predictive Factor? Completed NCT03469596
20 Molecular Biology of Anal Cancer in HIV-Positive Patients Completed NCT00952874
21 Anal Dysplasia in Patients With Inflammatory Bowel Disease Completed NCT01653054 Not Applicable
22 Malignant Progression of Anal Intra-epithelial Neoplasia in a Cohort of Patients Recruiting NCT01877135
23 Study of Anal Cytologies in Patients With High Grade Cervical Intraepithelial Neoplasia (CIN II and III) Recruiting NCT03241680 Not Applicable
24 Anal Cytology Collection Procedures in Predicting High-Grade Anal Dysplasia in Men Who Have Sex With Men Recruiting NCT02816879 Not Applicable
25 Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma Active, not recruiting NCT01858025 Early Phase 1 5-fluorouracil;Mitomycin-C
26 Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Not yet recruiting NCT03061435 Not Applicable
27 Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays Terminated NCT02407561

Search NIH Clinical Center for Anal Margin Carcinoma

Genetic Tests for Anal Margin Carcinoma

Anatomical Context for Anal Margin Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Anal Margin Carcinoma:

19
The Anal Margin (Where The Canal Meets The Outside Skin At The Anus)

MalaCards organs/tissues related to Anal Margin Carcinoma:

41
Skin

Publications for Anal Margin Carcinoma

Articles related to Anal Margin Carcinoma:

# Title Authors Year
1
HPV-73- and HPV-82 positive anal margin carcinoma with secondary ulcerating Herpes simplex-virus 2 infection. ( 21143394 )
2011
2
Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy. ( 3344351 )
1988

Variations for Anal Margin Carcinoma

Expression for Anal Margin Carcinoma

Search GEO for disease gene expression data for Anal Margin Carcinoma.

Pathways for Anal Margin Carcinoma

GO Terms for Anal Margin Carcinoma

Sources for Anal Margin Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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