Aliases & Classifications for Anal Spasm

MalaCards integrated aliases for Anal Spasm:

Name: Anal Spasm 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11374
ICD9CM 34 564.6
SNOMED-CT 67 17440005
ICD10 32 K59.4
UMLS 71 C0152167

Summaries for Anal Spasm

MalaCards based summary : Anal Spasm is related to anismus and splenic flexure cancer, and has symptoms including constipation, spasm and vomiting following gastrointestinal surgery. An important gene associated with Anal Spasm is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways are Neuroscience and Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. Affiliated tissues include spinal cord, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 74 Proctalgia fugax, a variant of levator ani syndrome, is a severe, episodic pain in the regions of the... more...

Related Diseases for Anal Spasm

Diseases related to Anal Spasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 anismus 10.5 CLCN2 APOLD1
2 splenic flexure cancer 10.4 STC1 APOLD1
3 cerebellopontine angle meningioma 10.4 DPYSL5 AMPH
4 plexopathy 10.4 DPYSL5 AMPH
5 glossopharyngeal neuralgia 10.3 POMC KANTR
6 endocrine exophthalmos 10.3 POMC APOLD1
7 anterograde amnesia 10.3 DPYSL5 AMPH
8 neurodermatitis 10.3 POMC KANTR
9 abducens nerve disease 10.3 POMC KANTR
10 la crosse encephalitis 10.3 DPYSL5 DPP6 AMPH
11 anal carcinoma in situ 10.3 CD4 APOLD1
12 intracranial arteriosclerosis 10.2 DPYSL5 AMPH
13 cerebellar disease 10.2 GAD2 DPYSL5 AMPH
14 limbic encephalitis 10.2 GAD2 AMPH
15 nephrotic syndrome, type 14 10.1 PTH POMC
16 autoimmune polyendocrine syndrome, type ii 10.1 GAD2 AIRE
17 cervical incompetence 10.1 SPTB PTPRN
18 adenohypophysitis 10.1 POMC CD4
19 fallopian tube endometrioid adenocarcinoma 10.1 PTPRN APOLD1
20 infancy electroclinical syndrome 10.1 SNAP25 POMC KANTR
21 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.1 GAD2 AIRE
22 stiff-person syndrome 10.1 GAD2 DPYSL5 DPP6 AMPH
23 neurosarcoidosis 10.1 DPYSL5 CD4 AMPH
24 autoimmune disease of peripheral nervous system 10.0 DPYSL5 CD4 AMPH
25 spinal cord disease 10.0 DPYSL5 CD4 AMPH
26 trichinosis 10.0 POMC CD4
27 scleredema adultorum 10.0 PTH POMC
28 dendritic cell thymoma 10.0 CD4 AIRE
29 laryngeal tuberculosis 10.0 POMC CD4
30 hypoparathyroidism, familial isolated 10.0 PTH AIRE
31 autoimmune peripheral neuropathy 10.0 CD4 AIRE
32 angular cheilitis 9.9 CD4 AIRE
33 esophageal candidiasis 9.9 CD4 AIRE
34 uveoparotid fever 9.9 POMC CD4
35 leptin deficiency or dysfunction 9.9 PTH POMC GAD2
36 lymphatic system cancer 9.9 DPYSL5 CD4 AIRE
37 hyperekplexia 9.9 KCND2 GAD2 DPYSL5 DPP6 AMPH
38 pancreatic cystadenoma 9.8 PTPRN POMC GAD2
39 cranial nerve palsy 9.8 POMC CD4
40 adrenal cortex disease 9.8 PTH POMC AIRE
41 adrenal gland disease 9.8 PTH POMC AIRE
42 graves disease 1 9.8 PTH POMC
43 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7 PTPRN GAD2 AIRE
44 brachydactyly, type c 9.7 PTPRN GAD2 CD4
45 whipple disease 9.7 TGM2 DPP6
46 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7 POMC CD4 AIRE
47 congenital myasthenic syndrome 9.7 STC1 SNAP25 KCND2 CD4
48 hair disease 9.7 POMC CD4 AIRE
49 thymus gland disease 9.7 DPYSL5 CD4 AMPH AIRE
50 thymus cancer 9.7 DPYSL5 CD4 AMPH AIRE

Graphical network of the top 20 diseases related to Anal Spasm:



Diseases related to Anal Spasm

Symptoms & Phenotypes for Anal Spasm

UMLS symptoms related to Anal Spasm:


constipation, spasm, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Anal Spasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 AIRE AMPH CD4 CLCN2 GAD2 POMC
2 nervous system MP:0003631 9.44 ADGRL3 AIRE AMPH CD4 CLCN2 DPP6

Drugs & Therapeutics for Anal Spasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Between Haemorrhoidectomy by Ligasure and Conventional Surgery Unknown status NCT03265990

Search NIH Clinical Center for Anal Spasm

Genetic Tests for Anal Spasm

Anatomical Context for Anal Spasm

MalaCards organs/tissues related to Anal Spasm:

40
Spinal Cord

Publications for Anal Spasm

Articles related to Anal Spasm:

(show all 16)
# Title Authors PMID Year
1
[Chronic anal fissure: etiopathogenesis, diagnosis, treatment]. 61
30531762 2018
2
Mucocele complicating stapled hemorrhoidopexy. 61
28273604 2017
3
Role of 0.4 % glyceryl trinitrate ointment after stapled trans-anal rectal resection for obstructed defecation syndrome: a prospective, randomized trial. 61
23943282 2014
4
Glyceryl trinitrate ointment did not reduce pain after stapled hemorrhoidectomy: a randomized controlled trial. 61
23102076 2012
5
Surgical management of hemorrhoids. State of the art. 61
21682110 2011
6
Botulinum toxin reduces anal spasm but has no effect on pain after haemorrhoidectomy. 61
18462246 2009
7
Closed anal sphincter manipulation technique for chronic anal fissure. 61
18792671 2008
8
Randomized clinical trial of botulinum toxin plus glyceryl trinitrate vs. botulinum toxin alone for medically resistant chronic anal fissure: overall poor healing rates. 61
16988850 2006
9
[Single surgical treatment for Hirschsprung's disease in patients with or without previous surgical procedures]. 61
16336798 2005
10
Use of radiofrequency in the treatment of minor anal pathology. 61
15285544 2004
11
[Usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy by the Milligan-Morgan's technique: results of a prospective randomized trial]. 61
14725229 2003
12
Sphincterotomy with radio frequency surgery: a new treatment technique of fissure in ano and associated pathologies. 61
12673378 2003
13
Ligation-anopexy for treatment of advanced hemorrhoidal disease. 61
11742181 2001
14
Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. 61
8702379 1996
15
[Proctalgia fugax. Differential diagnosis and therapy of fleeting anal cramp]. 61
1634166 1992
16
Can proctological procedures resolve perianal pruritus and mycosis? A prospective study of 23 cases. 61
1588219 1992

Variations for Anal Spasm

Expression for Anal Spasm

Search GEO for disease gene expression data for Anal Spasm.

Pathways for Anal Spasm

Pathways related to Anal Spasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SNAP25 POMC KCND2 GAD2
2 9.92 SNAP25 POMC

GO Terms for Anal Spasm

Cellular components related to Anal Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.17 XIRP1 SNAP25 PTPRN KCND2 GAD2 AMPH
2 voltage-gated potassium channel complex GO:0008076 9.13 SNAP25 KCND2 DPP6

Biological processes related to Anal Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.26 SNAP25 KCND2 GAD2 AMPH
2 negative regulation of calcium ion transport GO:0051926 9.16 STC1 PTH
3 response to vitamin D GO:0033280 8.8 STC1 PTH CD4

Molecular functions related to Anal Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 STC1 PTH POMC

Sources for Anal Spasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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