MCID: ANP007
MIFTS: 24

Anaplastic Ganglioglioma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Anaplastic Ganglioglioma

MalaCards integrated aliases for Anaplastic Ganglioglioma:

Name: Anaplastic Ganglioglioma 20 58 70

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

UMLS via Orphanet 71 C0431112
Orphanet 58 ORPHA251957
UMLS 70 C0431112

Summaries for Anaplastic Ganglioglioma

GARD : 20 Anaplastic ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma. In general, gangliogliomas are classified as grade I or low grade tumors, meaning that they grow slowly and are considered benign. Anaplastic gangliogliomas, however, are considered grade III or high grade tumors, which means that they are usually aggressive, malignant tumors. The main treatment is removal of the entire tumor during surgery. If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy. Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.

MalaCards based summary : Anaplastic Ganglioglioma is related to ganglioglioma and central neurocytoma. An important gene associated with Anaplastic Ganglioglioma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, myeloid and temporal lobe.

Related Diseases for Anaplastic Ganglioglioma

Diseases related to Anaplastic Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 ganglioglioma 30.9 NES GFAP
2 central neurocytoma 29.6 NES GFAP
3 malignant astrocytoma 29.5 NES GFAP
4 neurilemmoma 29.5 NES GFAP ACTC1
5 high grade glioma 29.4 NES GFAP
6 tuberous sclerosis 29.3 NES GFAP
7 hydrocephalus 29.3 NES GFAP
8 anaplastic astrocytoma 29.2 PMS2 NES GFAP
9 gliosarcoma 29.2 NES GFAP ACTC1
10 glioblastoma 10.2
11 glioma susceptibility 1 10.1
12 ataxia and polyneuropathy, adult-onset 10.1
13 pleomorphic xanthoastrocytoma 10.1
14 glial tumor 10.1
15 rare tumor 10.1
16 oligoastrocytoma 10.0 PMS2 GFAP
17 angiocentric glioma 10.0 GFAP ACTC1
18 cutaneous leiomyosarcoma 10.0 GFAP ACTC1
19 parachordoma 10.0 GFAP ACTC1
20 syringocystadenoma papilliferum 10.0 GFAP ACTC1
21 binswanger's disease 10.0 GFAP ACTC1
22 perineurioma 9.9 GFAP ACTC1
23 lynch syndrome i 9.9
24 osteogenic sarcoma 9.9
25 leukemia, acute myeloid 9.9
26 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
27 anaplastic pleomorphic xanthoastrocytoma 9.9
28 sensorineural hearing loss 9.9
29 amnestic disorder 9.9
30 respiratory failure 9.9
31 acoustic neuroma 9.9
32 eclampsia 9.9
33 obstructive hydrocephalus 9.9
34 gonadal dysgenesis 9.9
35 papilledema 9.9
36 adenocarcinoma 9.9
37 turner syndrome 9.9
38 lynch syndrome 9.9
39 ganglioneuroblastoma 9.9
40 cowden syndrome 9.9
41 neuroblastoma 9.9
42 myeloid leukemia 9.9
43 neurofibromatosis 9.9
44 intracranial hypertension 9.9
45 neurofibroma 9.9
46 glioma 9.9
47 headache 9.9
48 seizure disorder 9.9
49 low-grade astrocytoma 9.9
50 extraventricular neurocytoma 9.9

Graphical network of the top 20 diseases related to Anaplastic Ganglioglioma:



Diseases related to Anaplastic Ganglioglioma

Symptoms & Phenotypes for Anaplastic Ganglioglioma

Drugs & Therapeutics for Anaplastic Ganglioglioma

Search Clinical Trials , NIH Clinical Center for Anaplastic Ganglioglioma

Genetic Tests for Anaplastic Ganglioglioma

Anatomical Context for Anaplastic Ganglioglioma

MalaCards organs/tissues related to Anaplastic Ganglioglioma:

40
Spinal Cord, Myeloid, Temporal Lobe

Publications for Anaplastic Ganglioglioma

Articles related to Anaplastic Ganglioglioma:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Comment on: Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. 61
33211390 2021
2
Morphological diversity in H3G34-mutant high-grade gliomas: Ganglionic and epithelioid features. 61
32631482 2021
3
Primary Anaplastic Ganglioglioma of the Temporal Lobe With Brainstem Involvement: A Case Report and Literature Review. 61
33447489 2020
4
Spinal anaplastic ganglioglioma. 61
32969749 2020
5
Diffuse midline glioma of the cervical spinal cord with H3 K27M genotype phenotypically mimicking anaplastic ganglioglioma: a case report and review of the literature. 61
32451719 2020
6
MEK inhibition with trametinib is a successful therapy in ganglioglioma. 61
32999736 2020
7
Imaging of Neuronal and Mixed Glioneuronal Tumors. 61
32217897 2020
8
Awake Craniotomy for a Left Pan-Hippocampal Diffuse Low-Grade Glioma in a Deaf and Mute Patient Using Sign Language. 61
31790835 2020
9
Malignant Transformation of Pediatric Low-grade Gliomas: Report of Two Cases and Review of a Rare Pathological Phenomenon. 61
31512645 2019
10
Pediatric primary anaplastic ganglioglioma with malignant neuronal component. 61
32134601 2019
11
BRAF Inhibition in BRAFV600-Mutant Gliomas: Results From the VE-BASKET Study. 61
30351999 2018
12
Pediatric Intracranial Anaplastic Gangliogliomas: Illustrative Case and Systematic Review. 61
30098436 2018
13
Anaplastic ganglioglioma with epithelioid cell components. 61
29869356 2018
14
Cerebellopontine Angle Anaplastic Ganglioglioma Masquerading as Vestibular Schwannoma: Unusual Entity. 61
29929035 2018
15
Magnetic resonance imaging findings of mixed neuronal-glial tumors with pathologic correlation: a review. 61
29987554 2018
16
Impact of surgery, adjuvant treatment, and other prognostic factors in the management of anaplastic ganglioglioma. 61
29594461 2018
17
Unprecedented response to combination BRAF and MEK inhibitors in adult anaplastic ganglioglioma. 61
29335912 2018
18
Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. 61
29380516 2018
19
A case of adult anaplastic cerebellar ganglioglioma. 61
29527389 2018
20
Subtotal Resection of an Anaplastic Ganglioglioma in Pregnancy. 61
29862102 2018
21
Anaplastic Ganglioglioma Involving the Entire Length of the Spinal Cord. 61
29502115 2018
22
Pediatric primary anaplastic ganglioglioma with malignant neuronal component. 61
30102489 2018
23
Ganglioglioma Progression to Combined Anaplastic Ganglioglioma and Anaplastic Pleomorphic Xanthoastrocytoma. Case Report and Literature Review. 61
28939541 2017
24
Epileptic seizures in anaplastic gangliogliomas. 61
27550627 2017
25
Pediatric intracranial primary anaplastic ganglioglioma. 61
27921213 2017
26
Progression of atypical extraventricular neurocytoma to anaplastic ganglioglioma. 61
27597523 2017
27
Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. 61
27539475 2016
28
[Epilepsy-associated tumors of the central nervous system: Epilepsy surgery and oncological aspects]. 61
26676655 2016
29
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. 61
25850602 2015
30
Anaplastic ganglioglioma: a report of three cases and review of the literature. 61
25862009 2015
31
Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas. 61
24375920 2014
32
Histopathological and immunohistochemical profile in anaplastic gangliogliomas. 61
24028967 2013
33
A rare posterior cranial fossa tumor. 61
23361291 2012
34
Anaplastic ganglioglioma of the brainstem in an adult. 61
24028985 2012
35
Angiogenic potential of the cerebrospinal fluid (CSF) of patients with high-grade gliomas measured with the chick embryo chorioallantoic membrane assay (CAM). 61
23096357 2012
36
Pediatric primary anaplastic ganglioglioma: a case report and review of the literature. 61
22922381 2012
37
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. 61
22922809 2012
38
Anaplastic ganglioglioma in the spinal cord: case report and literature review. 61
23689037 2012
39
Outcome and prognostic features in anaplastic ganglioglioma: analysis of cases from the SEER database. 61
21626070 2011
40
Malignant ganglioglioma: case report and review of literature. 61
20524041 2011
41
Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog. 61
19895196 2010
42
Extraventricular neurocytoma with atypical features and ganglionic differentiation. 61
20399667 2010
43
Anaplastic ganglioglioma with malignant features in both neuronal and glial components--case report. 61
20339274 2010
44
Anaplastic ganglioglioma in children. 61
19043777 2009
45
Anaplastic ganglioglioma with gliosarcoma component. 61
19900112 2009
46
[Malignant progression of an anaplastic ganglioglioma into a glioblastoma multiforme--report on two cases and review of the literature]. 61
20506796 2009
47
Primary anaplastic ganglioglioma with a small-cell glioblastoma component. 61
18402388 2008
48
Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components. 61
18018481 2007
49
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. 61
17923741 2007
50
Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. 61
17611638 2007

Variations for Anaplastic Ganglioglioma

Expression for Anaplastic Ganglioglioma

Search GEO for disease gene expression data for Anaplastic Ganglioglioma.

Pathways for Anaplastic Ganglioglioma

Pathways related to Anaplastic Ganglioglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 NES GFAP
2 10.52 NES GFAP

GO Terms for Anaplastic Ganglioglioma

Cellular components related to Anaplastic Ganglioglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.16 NES GFAP
2 cell body GO:0044297 8.96 GFAP ACTC1
3 intermediate filament cytoskeleton GO:0045111 8.62 NES GFAP

Sources for Anaplastic Ganglioglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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